Andrographis paniculata, The Herbal Medicine Stops Plaques Accumulated in Neurons and Production of Inmature Neurons That Cause Alzheimer's disease, Scientists Say

Kyle J. Norton, Master of Nutrition 

Herbal Andrographolide may process a neural protective effect in the prevention of early onset of Alzheimer's disease, a common type of dementia, a study suggested.

Alzheimer's disease (AD) is a chronic neurodegenerative disease that is irreversible and starts slowly and worsens over time, affecting patients thinking ability and memory, correlated with major reductions of neurons to the respective target areas. The disease is named after German physician Alois Alzheimer.

Some researchers suggested that the disease is caused by a prolonged period of plaques excessive accumulation in the brain cells,  leading to brain cells degeneration and death.

People with Alzheimer's disease may experience the decline of cognitive and functional abilities, change of motions and moods and behavior, particularly, in reducing quality of life due to disability in physical activity.

According to the statistic provided by the Alzheimer.Net, approximately, 44 million people have Alzheimer’s or related dementia worldwide. The disease is most common in North America and Western Europe.

 Alzheimer’s disease is the 6th leading cause of death in the United States.

In the US, Alzheimer’s cost the United States taxpayer $259 billion in 2017.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.

The herb has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...

According to the joint study lead by the Pontificia Universidad Catolica de Chile, oral administrated natural product (Andrographolide, ANDRO) isolated from Andrographis paniculata in species Octodon degus (degu) exhibited the recovery of spatial memory and learning performance, through regulated phosphorylated tau protein and amyloid beta aggregate maturation in cell survival in inducing Alzheimer's disease.

Dr., the lead author in the joint study said, "(Andrographolide, ANDRO) inhibited) neural damage associated with aging processes and the behavioral and neuropathological hallmarks of aging-related diseases such as AD"

Additionally, Andrographolide also displayed the inhibitory activity of against forming of amyloid beta (Aβ)42 through suppression of NF-κB, a protein that regulates cell survival and function of microglia in activated response to brain damage and immunological stimuli together with the reduction in the production of pro inflammatory cytokines.

In animal study, mice treated with Andrographolide increased neural progenitor cell proliferation and decreased the number of immature neurons in the hippocampus, compared to age-matched control mice.

Moreover, ANDRO increased the number of newborn dentate granule neurons in various parts of the brain.

The study also found that the efficacy that reduces symptoms and protects against the early onset of the AD is the results of the stimulation of neurogenesis in the hippocampus.

Taking together, Andrographis paniculata is surely consisted as a therapeutic potential to protect the development of Alzheimer's disease through various mechanisms, however, intake of large amount daily should be taken with care.

However, additional data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of Andrographis paniculata anti-Alzheimer's disease possibilities.

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Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42 through Nrf2-Related Inflammatory Response by Seo JY1, Pyo E1, An JP1, Kim J1, Sung SH1, Oh WK1.(PubMed)
(2) Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus) by Rivera DS1, Lindsay C2, Codocedo JF2, Morel I3, Pinto C2, Cisternas P4, Bozinovic F5, Inestrosa NC6.(PubMed)
(3) Andrographolide Stimulates Neurogenesis in the Adult Hippocampus by Varela-Nallar L1, Arredondo SB1, Tapia-Rojas C2, Hancke J3, Inestrosa NC4.(PubMed)

*Aloe Vera, The Herbal Remedy That Delays Onset of Skin Aging Naturally, BioMedical Literature Reveal

Kyle J. Norton, Master of Nutrition


Aloe Vera or Aloe Vera supplement may be used to delay skin aging that causes expression of wrinkle, some scientists suggested.

Skin aging is a natural and biological process that change with age including wrinkles, age spots and dryness.

As we age, the skin also becomes thinner and loses fat, these conditions increase less plump and smooth. In case of injure, the skin also.takes longer to heal, too.

Wrinkle is a skin degenerative condition caused by the loss of dermis and subcutaneous fat layer underneath the skin, leading to a slight line or fold on the skin, particular in the face.

Unhealthy diet and life style also are major factors that increase early onset of skin aging.

Stacey Colino, a freelance Health & Wellness reporter at U.S. News, in the article of  "6 Surprising Factors That Can Accelerate the Aging of Your Skin" suggested that consuming lots of highly processed or sugary foods, always sleeping on the same side, being depressed, yo yo diet, long term intake of certain medicine such as corticosteroids, antibiotics, ACE inhibitors and diuretics and being a frequent flyer are also associated to prevalent risk factors of early aging(6).

Smoking causes over expression of free radicals that can damage skin cells in facilitated premature wrinkles.

Other causable factors such as stress, gravity, daily facial movement, obesity,..... and even sleep pattern may also have some effects in stimulated premature aging.

According to the University of Paris VI, free radical generation in the skin by UV light and from other sources, such as cellular infiltrations or the xanthine oxidase reaction also may contribute to at least retardation of premature cutaneous aging(4).

In the report of “Global Anti-Aging Market Research Report and Forecast to 2017-2022” published by OrbisResearch.com, the writer wrote, "The Global Anti-Aging Market was worth $250 billion in 2016 and estimated to be growing at a CAGR of 5.8%, to reach $331.41 billion by 2021" and "The future growth of anti-aging market is observed to rely on the advancement and technological development with enhanced efficacy and safety of anti-aging products"(5).

Aloe Vera is species of succulent plant in the genus Aloe, belongings to the Family Xanthorrhoeaceae, native to Sudan. een 

The plant is very popular for commercial cultivation due to its health benefits. Herbal Aloe Vera has used in traditional medicine to treat wound, burn healing, minor skin infections, sebaceous cysts, diabetes,....... and elevated of cholesterol.

According to the Food Ingredients & Technology Institute, daily oral intake of plant sterols of Aloe vera gel (Aloe sterol) significantly increases the skin barrier function, moisture, and elasticity in photoprotected skin of that may reduce risk of skin wrinkle.

In a 12-week, randomized, double-blind, placebo-controlled study, in 48 apparently healthy men (age range: 30-59 years; average: 45 years), intake of oral Aloe sterol supplementation after 12 weeks showed a significant improvement of the skin elasticity index in comparison in the baseline value.

Dr. Tanaka M, the lead author said, "Aloe sterol ingestion increased skin elasticity in the photodamaged skin of men aged <46 years, and "No Aloe sterol intake-dependent harmful phenomenon was observed during the intake period".

Furthermore, in vitro, Aloe sterols increased production of collagen and hyaluronic acid, natural substance in skin response to connective, epithelial, and neural tissues. approximately two-fold and 1.5-fold, and promoted gene expression levels in human dermal fibroblasts.

In fact, daily oral Aloe sterol-containing Aloe vera gel powder (AVGP) significantly reduced facial wrinkles in women aged ≥40 years as well as stimulated collagen and hyaluronic acid production by human dermal fibroblasts.

In support of the above evaluation, intake of Aloe Vera gel enhanced healthy skin through promoting elasticity (R2), net elasticity (R5), and biological elasticity (R7) scores and skin fatigue area F3,the Food Ingredients and Technology Institute 12 weeks study suggested.

Taking altogether, there is no doubt that oral administration of Aloe Vera or Aloe Vera supplements may improve skin condition including wrinkle, caused by skin aging, but quality of amount intake should only be prescribed by related field specialist. 

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effects of plant sterols derived from Aloe vera gel on human dermal fibroblasts in vitro and on skin condition in Japanese women by Tanaka M1, Misawa E1, Yamauchi K1, Abe F1, Ishizaki C2.(PubMed)
(2) Effects of Aloe Sterol Supplementation on Skin Elasticity, Hydration, and Collagen Score: A 12-Week Double-Blind, Randomized, Controlled Trial by Tanaka M1, Yamamoto Y, Misawa E, Nabeshima K, Saito M, Yamauchi K, Abe F, Furukawa F.(PubMed)
(3) Aloe sterol supplementation improves skin elasticity in Japanese men with sunlight-exposed skin: a 12-week double-blind, randomized controlled trial by Tanaka M1, Yamamoto Y2, Misawa E1, Nabeshima K1, Saito M1, Yamauchi K1, Abe F1, Furukawa F2.(PubMed)

(4) Free radicals and aging of the skin by Emerit I(PubMed)

(5) Global Anti-Aging Market 2017 is Growing Rapidly and Expected to Reach $331.41 billion by 2021 – Orbis Research
(6) Stacey Colino, a freelance Health & Wellness reporter at U.S. News, in the article of  "6 Surprising Factors That Can Accelerate the Aging of Your Skin"

*Asparagus, the Antidepressant Natural Whole Food, Biomedical Literature Suggested

By Kyle J. Norton, Master of Nutrition

Scientists may have found a dietary vegetable that processes a strong and profound impact in ameliorated psychological depression, recent study suggested.

Depression is a commonly psychological disease that affects your normal feeling, thinking and reacting to events that occur daily in your life.

People with depression may feel ashamed or afraid to ask for help. others suffer in silence.

According to the statistic of the World Health Organization, 300 million people around the world have depression. The numbers of  Americans suffer from depression are increasing at an alarming rate. As of today, 16.2 million adults in the United States or 6.7% of all adults have depression in the country.

Women are more susceptible to develop depression than men and fewer than half of those affected by depression in the world are seeking professional treatment. 

The disease is the leading cause of disability worldwide, and  a major contributor to the overall global burden of diseases.

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a love one, and illness. Over 30 million

Contrary to some misconceptions, depression can be treated and avoidable.

What cause depression? is debatable, however, genetic predisposition, personality, stress and brain chemistry are found to associate to the onset of the disease.

Chronic medical conditions also can trigger the development of depression. According to the study by the Shanghai University of Sport in the review of 60 articles with a total of 4311 patients, chronic diseases are highly correlated to the expression of depression and reduced quality of life(5).

The study also suggested that increasing SF-36 physical function subscale in such patients in short and long term may have a profound and positive effect in ameliorated depression and improved quality of life.

Use of antidepressants by conventional medicine,  may be effective. However, they can induce side effects of upset stomach, insomnia, sexual problems, anxiety, dizziness,..... and fatigue.

In severe cases, intake of anti depressant may cause serotonin syndrome, seizures, irregular heartbeat and unconsciousness and some people in the group of under the age of 25 may experience suicidal thoughts, according to the BBC report By Lesley Ashmall(6).

Asparagus is a flowering plant, belongings to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa and Western Asia.

The vegetable has been used from early times as a food and medicine, because of its delicate flavour and diuretic properties.

In an oral administration of methanolic extract of roots of AR (MAR) of the doses of 100, 200 and 400 mg/kg daily for 7 days and then subjected to forced swim test(FST) in mice, researchers found that application of the extract decreases immobility in FST and increases avoidance response in learned helplessness test (LH), an indication of antidepressant activity.

Dr. Singh GK, the lead author said, " MAR had insignificant effect on l-DOPA-induced aggressive behavior indicating absence of activity on dopaminergic system" and  "MAR has significant antidepressant activity and this effect is probably mediated through the serotonergic and the noradrenergic systems and augmentation of antioxidant defenses".

Furthermore, the injection of extracts of Asparagus cochinchinensis (AC) also expressed anti depressive effects, through inhibited oxidative stress that cause of neuro cell damage and improve cell signal reponse and signal transmitting.

Total saponin isolated from AC significantly is found ti inhibit free radical of H2O2 in induction of cell death in cultured cortical neurons.

Additional analysis suggested that AC antidepressant-like and neuroprotective (reducing infarct size) effects are associated to the activation of Shp-2 pathways which are associated to inhibition of depression in animal model.

Some researchers suggested that antidepressant activity of Asparagus racemosus (AR) may also be mediated by the neurotransmitters system, and cognitive activities possibly through the cholinergic system involved neuromuscular junctions, preganglionic neurons of the sympathetic nervous system....

Moreover, the study also showed that AR may be used as food and have potential drug-drug, drug-food and food-food interactions with drugs and foods, sharing the cholinergic and monoaminergic pathways in sending message between neuro cells, induced protective activities against development of depression.

These results suggested that asparagus ameliorated depression is it's neuroprotective effect by inhibited free radical that cause neuro cells damage and improved cell signal response.

However, further data collection on large example size and multi centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of asparagus anti depression possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Antidepressant activity of Asparagus racemosus in rodent models by Singh GK1, Garabadu D, Muruganandam AV, Joshi VK, Krishnamurthy S.(PubMed)
(2) The neuroprotective effects and possible mechanism of action of a methanol extract from Asparagus cochinchinensis: In vitro and in vivo studies by Jalsrai A1, Numakawa T2, Kunugi H2, Dieterich DC3, Becker A4.(PubMed)
(3) Asparagus racemosus competitively inhibits in vitro the acetylcholine and monoamine metabolizing enzymes by Meena J1, Ojha R, Muruganandam AV, Krishnamurthy S.(PubMed)
(4) Behavioural and neurochemical evaluation of Perment an herbal formulation in chronic unpredictable mild stress induced depressive model by Ramanathan M1, Balaji B, Justin A.(PubMed)
(5) Effect of traditional Chinese exercise on the quality of life and depression for chronic diseases: a meta-analysis of randomised trials by Wang X1,2, Pi Y3, Chen B1, Chen P1, Liu Y4, Wang R4, Li X1, Zhu Y5, Yang Y6, Niu Z(PubMed)
(6) The 'extreme' side-effects of antidepressants By Lesley Ashmall

*Detoxification: What Are The Internal Causes of Toxins Accumulated in Our Body? Scientists Explain

By Kyle J. Norton, Master of Nutrition

Western diet processed sugar, salt, and fat, artificial sweeteners, gluten, and genetically modified foods have strong impacts in induction of toxins that can cause harm to the health of our body.

 Unhealthy diet have a significant implication in weakened immune system against pathogens and digestive gut microbiome in absorbed nutrients and fluids for our body needs(9).

Some researchers suggested that our detoxifying functions try to get rid of them everyday, If they fail, over expression of toxins may cause disruption of hormone production, organs damage, leading to hormone imbalance and chronic illness.

The internal causes of toxins may include
1. Overdose of red meat
Today, animals are grown in a crowded environment and fed by growth hormones to perverse the maximum profits for commercial benefits.

No matter how restricted the government regulations are, these traces of growth hormone still remain in the animal body causing more harm than good.

Although our body requires protein and fat to function daily, overdose of red meat causes cholesterol building up in the arteries, triglyceride in the bloodstream, and high blood pressure, leading to risk of heart diseases and chronic ailments.

According to the article of  "Red meat triggers toxic immune reaction which causes cancer, scientists find" by Dr. Sarah Knapton, "...... that pork, beef and lamb contains a sugar which is naturally produced by other carnivores but not humans" and "It means that when humans eat red meat, the body triggers an immune response to the foreign sugar, producing antibodies which spark inflammation, and eventually cancer" and "... those who regularly ate 5.6oz (160g) of red meat a day had one third higher risk of bowel cancer". (1).

2. Refine sugar
Carbohydrates are essential to our liver and kidney function, overdose of sugar in American diet causes insulin resistance, damaging the pancreas, reducing the circulation of blood and causing hormone imbalance.

According to the article of 5 Questions and Answers About Glucose Toxicity by Alice Callahan, 

Glucose toxicity happens when chronically high glucose levels cause damage to the pancreas. Insulin is a very effective treatment, and it’s usually only needed temporarily(2).

Furthermore, the WebMD wrote, Western diet loads with sugar may cause damage to the brain, liver, skin, heart, kidney,... and reproductive organs(3).

3. Excessive  alcohol drinking
Our social life is a mess. We drink too much. Since alcohol is a stimulant, moderate drinking increases the circulation of blood and improves mental alertness.

Excessive drinking reduces the brain's function, pancreas dysfunction, damaging our liver, heart  and pancreas, decreasing the function of the immune system.

According to National Institutes of Alcohol Abuse(4), excessive alcohol drinking

* Interferes with the brain in transmitting information between cells and functioning, leading to  change mood and behavior change and think clearly and move with coordination. 

  * Can damage the liver, leading to liver disease and inflammations.

* Causes damage of pancreas,  leading to pancreatitis, a dangerous inflammation and swelling of the blood vessels in the pancreas.

* Can weaken your immune system, making your body a much easier target for disease.

*  Too much on a single occasion can damage the heart, causing problems.

4. Artificial Agents
Artificial agents may help to perverse food and make it look good, but they are toxic to our body. These types of agents stimulate appetite by directly influencing the hunger centers of the brain causing you to eat more resulting in obesity.

According to the University of Pennsylvania, artificial sweetener have a strong effect in stimulated the development of lymphomas, leukemias, cancers of the bladder and brain, chronic fatigue syndrome, Parkinson's disease, Alzheimer's disease, multiple sclerosis, autism, and systemic lupus(5).

Some researchers suggested that intake of synthetic flavorings, nature identical and artificial cause toxicity to hematopoietic tissue cells in rodents's study(6) and under the study conditions, synthetic flavorings of passion fruit and strawberry, and artificial synthetic flavorings, vanilla, chocolate, tutti-frutti and cookie microingredients induced cytotoxic and genotoxic, and additives strawberry, chocolate and cookie are also mutagenic(6)..

5. Smoking
Smoking not only causes lung cancer, it also causes the depletion of oxygen levels in the bloodstream, increasing the risk of hardening, thickening and calcium attached in arterial wall(7) as well as increasing the risk of heavy metals accumulating in the brain, kidney and testis  (8).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Red meat triggers toxic immune reaction which causes cancer, scientists find by Dr. By Sarah Knapton
(2) 5 Questions and Answers About Glucose Toxicity by Alice Callahan
(3) How Does Too Much Sugar Affect Your Body? By Locke Hughes
(4) Alcohol's Effects on the Body by National Institute of Alcohol Abuse
(5) The potential toxicity of artificial sweeteners by Whitehouse CR1, Boullata J, McCauley LA(PubMed)
(6) Toxicity of synthetic flavorings, nature identical and artificial, to hematopoietic tissue cells of rodents by Braz. J. Biol. vol.78 no.2 São Carlos May/Aug. 2018 Epub Aug 17, 2017
(7) Longitudinal Associations of Cigarette Prices with Smoking Cessation: the Coronary Artery Risk Development in Young Adults (CARDIA) Study by Mayne SL1, Gordon-Larsen P2, Schreiner PJ3, Widome R3, Jacobs DR3, Kershaw KN(PubMed)
(8) Cadmium, Organ Toxicity and Therapeutic Approaches: A Review on Brain, Kidney and Testis Damage by Rinaldi M1, Micali A2, Marini H1, Adamo EB2, Puzzolo D2, Pisani A2, Trichilo V1, Altavilla D2, Squadrito F1, Minutoli L(PubMed)
(9) The Impact of Diet and Lifestyle on Gut Microbiota and Human Health by Michael A. Conlon* and Anthony R. Bird(PubMed)

Detoxification: The Herbal Remedies That Detox and Nourish Our Body For Optimal Health

Western diet or standard American diet (SAD) is a modern dietary pattern characterized by high-carb foods with low in nutrients, manufactured trans fats in the form of hydrogenated or partially hydrogenated oils, unrefined sugar, molasses, cane syrup and maple syrup,.... and refined flour.

In a long-term, all these foods can overwhelm the body organs, causing toxins accumulation that can lead to varying types of chronic illness.

Sadly but truthfully,  the health line in the article of "The Effects of Fast Food on the Body" wrote, " millennials alone spend 45 percent of their budget’s food dollars on eating out'. and "In comparison to 40 years ago, the average American family now spends half their food budget on restaurant food. In 1977, just under 38 percent of family food budgets were spent eating outside the home".

Continuously, the author suggested that these types of  fast foods only cause digestive and cardiovascular, respiratory, central nervous system, reproductive,  integumentary and skeletal disorders but also induce a strongly negative effects on society, including more than one-third of children ages 6 to 19 are also considered overweight or obese and financial burden to the health care system.

Dr. Donjete Statovci, at the University College Cork, in the study of "The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces" said, "Recent reports indicate that the gut microbiota and modifications thereof, due to a consumption of a diet high in saturated fats and low in fibers, can trigger factors regulating the development and/or progression of both conditions"(2).

Herbal Remedies That Detox and Nourish Our Body include

1. Garlic
Garlic is a widely used medication in the world.

The herb has a proven record for prevention and treatment of heart disease(3) by decreasing the risk factors of hypertension and high blood cholesterol through its form of aged garlic extract and protection of liver from being damaged by the forming of free radicals through it's a form of garlic juice(4).

Furthermore, application of garlic extract also strengthens our system's fighting against the degeneration of our body, though it's a form of aqueous garlic extract(5).

2. Gotu Kola
Gotu Kola is also known as cetenlla asiatica. It is said to have a strong effect in treating nervous system disorder caused by inflammation(6) and improving learning and memory(7).

It's antioxidant property also rejuvenates our body against the forming of free radicals(8) and protects against early aging(9).

3. Astragalus
Astragalus contains antioxidants(10) that have been used in traditional Chinese medicine for strengthening our body in fighting against oxidative stress in the induction of diseases.

The herbal medicine also processes anti-virus and anti-bacterial properties(11), and promotes selectively in modulated cells of the immune system(11).

4. Reishi Mushroom
Reishi Mushroom contains ganoderic acids that strengthen our immune system's fight against inflammation(12) and abnormal cell growth in the induction of cancers(12).

The herb also keeps our liver in top form and improves the circulation of blood and increases the oxygen level in the bloodstream(13).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) The Effects of Fast Food on the Body by health Line
(2) The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces by Statovci D1, Aguilera M1, MacSharry J1,2, Melgar S(PubMed)
(3) Garlic and Heart Disease by Varshney R1, Budoff MJ(PubMed)
(4) Antioxidant effects of heated garlic juice on cadmium-induced liver damage in rats as compared to ascorbic acid by Olalekan Lawal A1, Lawal AF, Ologundudu A, Adeniran OY, Omonkhua A, Obi F.(PubMed)
(5) Protective effects of aqueous garlic extract in reducing water avoidance stress-induced degeneration of the stomach, ileum, and liver: morphological and biochemical study by Zeybek A1, Ercan F, Cetinel S, Cikler E, Saglam B, Sener G(PubMed)
(6) Neuroprotective effect of a standardized extract of Centella asiatica ECa233 in rotenone-induced parkinsonism rats by Teerapattarakan N1, Benya-Aphikul H2, Tansawat R3, Wanakhachornkrai O4, Tantisira MH5, Rodsiri R(PubMed)
(7) Study of ameliorating effects of ethanolic extract of Centella asiatica on learning and memory deficit in animal models by Doknark S, Mingmalairak S, Vattanajun A, Tantisira B, Tantisira MH(PubMed)
(8) Total phenolics and antioxidant activities of fenugreek, green tea, black tea, grape seed, ginger, rosemary, gotu kola, and ginkgo extracts, vitamin E, and tert-butylhydroquinone by Rababah TM1, Hettiarachchy NS, Horax R(PubMed)
(9) Trends in aging and skin care: Ayurvedic concepts by Datta HS1, Paramesh R(PubMed)
(10) Mineral and Phytochemical Profiles and Antioxidant Activity of Herbal Material from Two Temperate Astragalus Species. by Butkutė B1, Dagilytė A2, Benetis R2, Padarauskas A3, Cesevičienė J1, Olšauskaitė V3, Lemežienė N(PubMed)
(11) Immunomodulatory and antimicrobial effects of some traditional chinese medicinal herbs: a review by Tan BK1, Vanitha (PubMed)
(12) Immunomodulatory and Antitumoral Properties of Ganoderma lucidum and Agaricus brasiliensis (Agaricomycetes) Medicinal Mushrooms by Rubel R1, Santa HSD1, Dos Santos LF2, Fernandes LC3, Figueiredo BC4, Soccol CR(PubMed)
(13) Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers by Chiu HF1, Fu HY2, Lu YY3, Han YC2, Shen YC4, Venkatakrishnan K2, Golovinskaia O5, Wang CK(PubMed)
(14) Cardioprotective Activity of Ganoderma lucidum Extract during Total Ischemia and Reperfusion of Isolated Heart by Lasukova TV1, Maslov LN, Arbuzov AG, Burkova VN, Inisheva L(PubMed)

Detoxification: What Are The External Causes of Toxins Accumulated in Our Body?

By Kyle J. Norton

The human body has adapted to the change of environment over thousands of years by properly responding to external conditions. The lymphatic system expressed its function when the body is cold by secreting sweet through the skin and the cells send signaling to request for water when the body is dehydration.  

However, when the body no longer can adjust to long-term toxins accumulation,  the signs of discomfort and disease appear, leading to symptoms of a headache, fever, nausea, vomiting,...... and diarrhea. 

Toxins are chemical agents if overwhelm the body tissue can cause dysfunction of the internal organs, leading overexpression of free radicals in the induction of chronic diseases.

Symptoms of toxic organs share a similar trail with biological agents such as bacteria or viruses. 

To better understand how the disease is caused by exposure to toxic chemicals, we must first understand how poisons work within the body.

According to the joint article of " Manifestations of Toxic Effects" lead by the Cornell University, researchers wrote, "Toxicity is normally divided into four types, based on the number of exposures to a poison and the time it takes for toxic symptoms to develop. The two types most often referred to are acute and chronic" and " Most toxic effects are reversible and do not cause permanent damage, but complete recovery may take a long time. However, some poisons cause irreversible (permanent) damage".(1)

Here are the most common external causes of toxin accumulation in the body

1. Air Pollution
The cause of air pollution is the result of the burning of fossil fuels such as coal, oil, natural gas, and gasoline to produce electricity and power our vehicles such as the emitting of carbon dioxide resulting in ozone pollution, acid rain, and toxic heavy metal pollution.

In the study of environmental pollution, Dr. Marilena, the lead author wrote in Volume 151, Issue 2, January 2008, Pages 362-367, "Air pollution has both acute and chronic effects on human health, affecting a number of different systems and organs. It ranges from minor upper respiratory irritation to chronic respiratory and heart disease, lung cancer, acute respiratory infections in children and chronic bronchitis in adults, aggravating pre-existing heart and lung disease, or asthmatic attacks" and "In addition, short- and long-term exposures have also been linked with premature mortality and reduced life expectancy".

Yes, this is the air we breathe every day. Every breath we inhale, our body is required to detoxify all this harmful material entering our body.

If the body systems (circulatory, digestive, endocrine, excretory, immune, integumentary, muscular, nervous, reproductive, respiratory, and skeletal) are weakened, some of these harmful cannot be removed from our body that can cause heavy metal accumulation and  disrupt the normal function of organs and lead to inflammation and infection.

2. Soil Pollution
Soil pollution is caused by misuse of the soil in poor agricultural practices, mineral exploitation, industrial waste dumping, and indiscriminate disposal of urban wastes.

These kinds of wastes accumulating in our soil include herbicides, pesticides, heavy metals and man-made chemicals that will enter our body through raining, snowing and foods.

Dr. Sónia M.Rodrigues and Dr. Paul F.A.M.Römkens, the scientists expressed in the Chapter 9 - Human Health Risks and Soil Pollution, " Accumulation of toxic chemical pollutants and soil-borne pathogens in soils resulted in increased human exposure either via inhalation, dermal contact or ingestion of soil, or indirect exposure via dietary intake or drinking water" and " It is, therefore, crucial to develop tools to assess potential risks of human exposure to pollutants and to determine meaningful threshold concentrations in soils in order to protect human health"(3).

Long-term accumulation of these harmful substances will disable the body system, leading to the development of chronic diseases.

3. Water pollution
An estimated 90% of wastewater is discharged directly into rivers and streams without treatment.

According to the reports by CBC, "More than 205 billion liters of raw sewage and untreated wastewater spewed into Canada's rivers and oceans last year, CBC News has learned, despite federal regulations introduced in 2012 to try to solve the problem"(4).

Other causes of water pollution include poorly designed landfills, road deicing salts, and hazardous waste sites, these harmful substances of heavy metals and chemical substances can enter the water that we drink every day.

4. Indoor pollution
Indoor pollution such as gas heaters, gas appliances, wood burning fireplaces, leaking chimneys and furnaces, and tobacco smoke causes allergic reactions such as eye, nose and throat irritation, and weakening our immune system.

According to the book of Indoor Pollution charter VII health effects of indoor pollution, " Pollutants are inhaled, ingested, and absorbed. They may have effects at their first point of contact with the body, or they may affect internal organs" and "( In compared to injection and absorption) Inhalation is generally the most important route by which toxic substances enter the body. Inhaled substances may exert their effects in the lungs, or they may pass from the lungs to other organ systems in blood, lymph, etc"(5).

5. Toxins in Food
Certain foods are more toxic than others, such as french fries, BBQ chicken, and most fast foods which contain a high quantity of trans-fat that has been shown to be carcinogenic. Fruits and vegetables that grow in the contaminated soils or herbicides used on them, will absorb the contamination substances.

People who have an occupation in dealing with natural food toxins may cause toxins accumulated in the body. The WHO in the article of food fact, wrote, "Some natural toxins can be formed in food as defense mechanisms of plants, through their infestation with toxin-producing mold, or through ingestion by animals of toxin-producing microorganisms." and "Long-term health consequences include effects on the immune, reproductive or nervous systems, and also cancer"(6).

Also, Stacy Kennedy, MPH, RD, CSO, LDN; Reboot Nutritionist in the article of 5 Chemicals That Turn Our Food Toxic (and how to avoid them!) suggested Bisphenol-A, aka “BPA.”, the estrogen-like man-made chemical is pervasive in canned foods; Bromated Vegetable Oil, aka “BVO.”, the chemical enhances the bright colors in many bottled beverages like soda, sports drinks, and citrus-flavored drinks; Benzoate Preservatives, aka “BHT, BHA, TBHQ.”, the chemicals are used to help keep fats in foods from going rancid; Perfluorooctanoic acid, aka “PFOA.”, the paper and lining of microwave popcorn bags contain PFOAs and Azodicarbonamide, the bleaching agent used in packaged, processed foods like frozen dinners, pasta and flour mixes in baked goods(7).


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.Sources
(1) Manifestations of Toxic Effects by Cornell University, Michigan State University, Oregon State University, and University of California at Davis

(2) Human health effects of air pollution by Marilena Kampa and Elias Castanas

(3)  the scientists expressed in the Chapter 9 - Human Health Risks and Soil Pollution by Dr. Sónia M.Rodrigues and Dr. Paul F.A.M.Römkens,

(4) Billions of litres of raw sewage, untreated waste water pouring into Canadian waterways by Elizabeth Thompson ·

(5) Indoor Pollution charter VII health effects of indoor pollution 

(6) Natural toxins in food(WHO)

(7) Stacy Kennedy, MPH, RD, CSO, LDN; Reboot Nutritionist in the article of 5 Chemicals That Turn Our Food Toxic (and how to avoid them!) 

* The Herbs and Plants That Detox and Nourish Our Body For Optimal Health

Western diet or standard American diet (SAD) is a modern dietary pattern characterized by high intakes of surated and trans fats, red meat, processed meat, pre-packaged foods and refined grains and sugar, butter, fried foods, eggs, ,......and high-sugar. In a long term, all these foods can overwhelm   the body organs, leading toxins accumulated in the body in induction of chronic illness.

According to Bjørknes University College, the dietary pattern is strongly associated with obesity and related metabolic and inflammatory diseases, caused by structural and behavioral changes in the resident microbiome(1).

Dr. Donjete Statovci,at the University College Cork, in the study of "The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces" said, "Recent reports indicate that the gut microbiota and modifications thereof, due to a consumption of a diet high in saturated fats and low in fibers, can trigger factors regulating the development and/or progression of both conditions"(2).

Truly, in the article by wholistic matters, the authors suggested, "most toxins are lipophilic and readily cross cell membranes, where they can disrupt normal cellular functions. Among other adverse actions, toxins can bind to proteins, inhibit enzyme function, and interact with DNA.  Because they are lipophilic, toxins tend to accumulate in tissues rich in fat such as adipose tissues, liver, and brain" and  "Evidence suggests that inadequate clearance of toxins can play a role in the development of obesity, cardiovascular disease, neurocognitive conditions, immune dysfunction, and chemical"(3).

Chinese herbal medicine have been used over thousand of years for treatment of over and deficiency syndrome caused  by"toxins" accumulated in the body.

1. Fo ti Tieng (He Show Wu)
According to traditional Chinese medicine, Fo ti Tieng is considered as a tonic adaptogen that processes a significant effect in tonifying kidney, blood  and liver and expelling toxins. Further more, the herb has been used to replenish the "root of our vitality", the kidney Jing essence to all vital organ systems.(5)

In extensive research by scientists in modern medicine, fo ti was found to process substantial effect in protected liver, nerve system, circulatory and immune system(4).

In other words, the herb protect all organs by detoxifying toxins that cause damage to kidney and liver and heart and nerve and immune system.


2. Ginko biloba (Yin xing)
Flavonoid glycosides and terpenoids isolated from extract of the Ginkgo leaves have a profound effect in improved blood flow(6) in the brain and peripheral circulation and reduced immunotoxins(6) by stimulating production of antioxidants from the host that reduces oxidative stress and over expression of free radicals(7).

3. Ginseng
Ginseng is a slow-growing perennial plant with fleshy roots, in the family araliaceae. The herbal medicine not only has a profound effect in treating type I and II diabetes(8) and sexual dysfunction(9) in men but also improves the body immune system(10), stimulates the production of growth hormone(11) and protects skin against aging(12).

4. Dandelion roots ( Pu Gong Yin )
Dandelion roots is a small rosette-forming perennial plant with a long thin taproot and a clump of entire or sinuate leaves.

The herb has a proven record in cleansing the toxins accumulated in the liver, including hepatitis infection(13), pancreas(13) and digestive system(13).


5. Jin Yin Hua
Jin Yin hua belongings to a family of caprifoliaceae. The herb has been used for heat-clearing, detoxification,.... in traditional Chinese medicine.

According to the Chung-Ang University, Jin yin hua  processes a significant effect in improved gastro-intestinal (GI) activity by enhancing the gastric emptying (GE) and gastro-intestinal transit (GIT)(14).

The herbal medicine strengthens the body's immune system's fight against extensively drug-resistant enterobacteria and nonfermentative bacteria infection(15) and stimulates production of antioxidant in inhibited of free radicals(16).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease by Marit K. Zinöcker1,* and Inge A. Lindseth(PMC)
(2) The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces by Statovci D1, Aguilera M1, MacSharry J1,2, Melgar S(PubMed)
(3) Metabolic Detoxification by Wholistic Matters
(4) 20 Health Benefits of Polygonum Multiflorum or Fo-ti by Self Hack
(5) Chinese Herbs – He Shu Wu (Radix Polygoni Multiflori) by Kyle J. Norton
(6) Ginkgo biloba by Science Direct
(7) Effect of the antioxidant action of Ginkgo biloba extract (EGb 761) on aging and oxidative stress by PMC
(8) The Efficacy of Red Ginseng in Type 1 and Type 2 Diabetes in Animals by Bin Na Hong, 1 , 2 Min Gun Ji, 2 and Tong Ho Kang(PMC)
(9) Red ginseng for treating erectile dysfunction: a systematic review by Dai-Ja Jang,1 Myeong Soo Lee,2,3 Byung-Cheul Shin,4 Young-Cheoul Lee,1 and Edzard Ernst(PMC)
(10) Ginseng, the 'Immunity Boost': The Effects of Panax ginseng on Immune System by Soowon Kang and Hyeyoung Min(PMC)
(11) Effects of ginseng ingestion on growth hormone, testosterone, cortisol, and insulin-like growth factor 1 responses to acute resistance exercise by Youl Kang H1, Hwan Kim S, Jun Lee W, Byrne HK(PubMed)
(12) Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin by Eunson Hwang,1,☆ Sang-Yong Park,1,☆ Chang Shik Yin,2 Hee-Taek Kim,3 Yong Min Kim,3 andTae Hoo Yi(PubMed)
(13) Plants Consumption and Liver Health By Yong-Song Guan and Qing He(PubMed)
(14) The effect of Flos Lonicerae Japonicae extract on gastro-intestinal motility function by Nam Y1, Lee JM2, Wang Y3, Ha HS4, Sohn UD(PubMed)
(15) Effectiveness of Chinese Herbal Medicine Combined with Antibiotics for Extensively Drug-Resistant Enterobacteria and Nonfermentative Bacteria Infection: Real-Life Experience in a Retrospective Cohort by Yangping Cai, 1 Qing Zhang, 1 Yuefeng Fu, 1 Li Li, 2 Ning Zhao, 2 Aiping Lu, 3 Qingquan Liu, 4 andMiao Jiang(PubMed)
(16) Rapid and simple method for screening of natural antioxidants from Chinese herb Flos Lonicerae Japonicae by DPPH-HPLC-DAD-TOF/MS by Tang D1, Li HJ, Chen J, Guo CW, Li P.(PubMed)