* The Root Vegetable That Prevents Macular Degeneration (AMD), Biomedical Literature Suggest

Kyle J. Norton

Carrots may have a profound and positive effect in prevention of mascular degeneration, some scientists suggested.


Macular degeneration is a condition characterized by deterioration of the macula, the small central area of the retina of the eye that controls visual acuity.

Symptoms of early signs of AMD include central vision shadows or unusually fuzzy or distorted vision. 

According to statistic, approximately 6 percent of Americans age 40 and older have some forms of macular degeneration.

There are 2 types of macular degeneration, the dry and wet form.

The dry form is one of most common of macula degeneration accounted for over 85 to 90 % of the disease.

Dry macular degeneration also known as non-neovascular is an early stage of the disease caused by aging and thinning of macular tissues, leading to gradual central vision loss. 

In compared to the dry form, wet macular degeneration (neovascular) is a severed and advanced stage of the disease caused by new blood vessels grow beneath the retina and leak blood and fluid causing permanent damage to light-sensitive retinal cells in induction of blind spots in central vision.

Untreated or advanced stage of wet form AMD are also complicated by complete vision loss.

Dr. Ikram MK the lead author at the Singapore National Eye Centre study, said, "Persons with AMD are (regardless of treatment or not) at an increased risk of both cerebral infarction and intracerebral hemorrhage" and  "These data (the study) provide further insight into common pathophysiological processes between AMD and stroke subtypes"(4).

Conventional medicine used for treatment of AMD, such as Lucentis approved by FDA in 2006 can increase risk of heart attack and stroke.

Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.


In the investigated the effect of major bioactive phytochemicals lutein and zeaxanthin isolated from orange pigment vegetables, including carrot in eye health, researchers at the Guelph Food Research Centre, found that application of indicated compounds exert a significantly protective effect of the yellow spot of the human retina which protect the macula from damage by blue light and improve visual acuity and scavenge harmful reactive oxygen species. 

Long term exposure to the blue light may cause structural, thermal and photochemical damage to the retinal, particularly, in aging population.

Further analysis also suggested that application of lutein and zeaxanthin increased antioxidants and stimulated natural antioxidants produced by the body tissue in inhibited over expression of free radicals and theirs chain of domino's effects caused by sunlight exposure in induction of oxidative stress.

The restoration of balance of the ratio of reactive oxygen species and antioxidants not only prevented oxidative damage to the cells of retina, but also reduced risk of age-related macular degeneration (AMD) and cataracts, according to the research over the past decade in focused on the development of carotenoid-rich foods to boost their intake especially in the elderly population

Dr. Abdel-Aal el-SM, after taking into account of other co and con founders said, "The review also lists major dietary sources of lutein and zeaxanthin and refers to newly developed foods, daily intake, bioavailability and physiological effects in relation to eye health".

These suggestion not only addressed a strong protective effect of bioactive compound carotenoids found abundantly in carrot in improved eye health but also recommended daily and regular intake of a moderate amount of carrot in aging risk of macular degeneration.

Additionally, in the evaluation of the possibility of macular carotenoids, lutein (L), and zeaxanthin (Z) in ameliorated the retardation of age-related changes in the eye and prevention of the eye diseases such as cataract and macular degeneration, researchers at the University of Georgia suggested that intake of carotenoids rich food, such as carrot in the early life may be the best to protect against eye diseases due to aging.

The benefits of early carotenoids consumption in protected against retard age-related changes in the eye and the eye diseases were associated to influence of the development of the visual system through
* Altered input during a critical/sensitive period of visual development and/or

* Influenced maturation and/or

*Protected the retina during a period when it was particularly vulnerable.

Interestingly, in the differentiation of lutein and zeaxanthin accumulated throughout the tissues of the eye, specially in the central retina, researchers once again strongly found that circulated pigments' antioxidants serve a variety of roles in the specialized human vision, including all aspects of visual performance.

Taken together, Carrot with high amount of carotenoids ( lutein (L), and zeaxanthin) may be considered as functional food in prevention of eye diseases, particularly in older adult.

People with higher risk of eye diseases may want to add a portion of carrot into their daily diet for preventive measure. And intake of carrot extracts should be taken as acute liver toxicity has been reported in numbers of supplement.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Dietary sources of lutein and zeaxanthin carotenoids and their role in eye health by Abdel-Aal el-SM1, Akhtar H, Zaheer K, Ali R.(PubMed)
(2) Possible role for dietary lutein and zeaxanthin in visual development by Hammond BR Jr1(PubMed)
(3) Dietary lutein and zeaxanthin: possible effects on visual function by Stringham JM1, Hammond BR Jr.(PubMed)
(4) Age-related macular degeneration and long-term risk of stroke subtypes by Ikram MK1, Mitchell P, Klein R, Sharrett AR, Couper DJ, Wong TY(PubMed)

* The Veggie and Its Bio Active Compounds That Prevent Stroke

Kyle J. Norton

Carrots may have a profound and positive effect in reduced risk of stroke, some scientists suggested.

Stroke is a medical condition caused by reduced blood flow to the brain resulting in cell death due to blocked artery (ischemic stroke) or the leaking or bursting of a blood vessel (hemorrhagic stroke).

There is a general belief that stroke is an accumulation over along period of unhealthy diet with red meat and processed meats in induction of artery-clogging.

Some researchers suggested that increased intake of fruits and vegetables such as carrot accompanied with good fats such as salmon, tuna, and mackerel may have a substantial effect in reduced inflammation in the arteries, improved blood flow and decreased the chance of blood clots.

Sadly, stroke is one of the most common causes of death worldwide.

In US, according to statistic, approximately 800,000 people suffer a stroke in which 600,000 of these are first attacks, and 185,000 are recurrent attacks. Nearly three-quarters of all strokes occur in people over the age of 65.

Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

In the review of literature published to understand more of the role of carotenoids as antioxidants in lowering stroke risk based on observational studies, researchers at the Isfahan University of Medical Sciences conducted a search with some important keywords, including (Carotenoids [MeSH] OR Carotenes [tiab] OR Carotene [tiab] OR "lycopene [Supplementary Concept]" [MeSH] OR lycopene [tiab] OR beta-Carotene [tiab]) AND (stroke [MeSH] OR stroke [tiab] OR "Cerebrovascular Accident" [tiab] OR "Cerebrovascular Apoplexy" [tiab] OR "Brain Vascular Accident" [tiab] OR "Cerebrovascular Stroke" [tiab]) AND ("oxidative stress" [MeSH] OR "oxidative stress"[tiab]).

The results of the searching of papers published between 2000 and 2017 suggested that

* High dietary intake of six main carotenoids (i.e., lycopene, <- and®-carotene, lutein, zeaxanthin, and astaxanthin) was associated with reduced risk of stroke due to their benefits in reduced over expression of reactive oxygen species.

* Beyond the antioxidant activities in prevented free radical in induction of chain reaction, other properties and mechanisms in ameliorated risk of stroke were not identified in studies sanctified the guideline and criteria.

These results suggested that dietary intake of six major carotenoids may be considered as stroke prevention and stroke mortality reduction.

Further in differentiation the benefits of lycopene an bioactive member in carotenoids, researchers found that intake of food containing high amount of lycopene demonstrates a substantially reduced risk of stroke in compared to non takers.

According to the assessment of pooled analysis of seven prospective studies, with 116,127 participants and 1,989 cases, frequent consumption of lycopene decreased stroke risk by 19.3%, after adjusting for confounding factors.


In gender and geographic analysis, researchers also stated that lycopene exerts a strong impact in prevent onset of stroke, particularly in European and male gender.

Dr. the lead scientist said, " Duration of follow-up had no effect on the final results. There was no evidence of publication bias" and " Lycopene, especially circulating lycopene, is negatively associated with stroke risk".

Additionally, in the examine the hypothese whether low serum levels of lycopene are associated with increased risk of acute coronary events and stroke in middle-aged men previously free of CHD and stroke , researchers launched an investigation of 725 men aged 46-64 years examined in 1991-3 in the Kuopio Ischaemic Heart Disease Risk Factor Study.

By December 1997, out of 725 patients, 41 men were found to have either a fatal or a non-fatal acute coronary event or a stroke.

According to the observation of a Cox' proportional hazard's model and after adjusting to examination years, age, systolic blood pressure and three nutritional factors (serum folate, beta-carotene and plasma vitamin C), researchers found that all 41 men are in the lowest quarter of serum lycopene levels.

These results once again suggested that daily intake of lycopene rich foods to increase the circulating lycopene plays an essential role in prevented risk of atherosclerotic vascular events in middle-aged men previously free of CHD and stroke.

Truly, patients with lower levels of serum lycopene were found to had a 3.3-fold risk of acute coronary events or stroke in compared with the others.

Taken together, carrot with high ammount of bioactive carotenoids, especially lycopene may be considered as a function food in reduced the prevalent risk of stroke.

People who are at the higher quarter of stroke risk may want to add a portion of carrot into their daily diet for preventive measure.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Carotenoids as Potential Antioxidant Agents in Stroke Prevention: A Systematic Review by Bahonar A1, Saadatnia M1, Khorvash F1, Maracy M2, Khosravi A(PubMed)
(2) Dietary and circulating lycopene and stroke risk: a meta-analysis of prospective studies by Li X1, Xu J2.(PubMed)
(3) Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study by Rissanen TH1, Voutilainen S, Nyyssönen K, Lakka TA, Sivenius J, Salonen R, Kaplan GA, Salonen JT.(PubMed)
(4) Healthy eating and stroke(Stroke Foundation)
(5) Stroke Statistics by The Internet Stroke center

* How to Normalize Your Sex Hormones Androgen and Estrogen Naturally, Revealed by Scientists

By Kyle J. Norton

Coffee, a popular and social beverage, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

A recent study suggested that coffee may have a direct effect in influence of sex hormone steroid-binding globulin(SSBG) in stimulated production of estrogen and androgen depending to levels in the host.

Sex hormones are class of hormones, affecting sexual development and reproduction. Steroid-binding globulin(SSBG), is a sex hormone, having a direct effect on androgen and estrogen.

In sex hormones and sexual differentiation, most influential hormone in human sexual desire is testosterone.

Low levels of estrogen in women can also reduce sex drive caused by vaginal dryness that can lead to painful intercourse

Mentally, women with low levels of estrogen also experience unstable mood and sleep patterns that can have a strong impact in sexual desire.

However, sexual motivation is influenced by a set of hormones, including testosterone, estrogen, progesterone, oxytocin, and vasopressin...... Altogether, they control the ability to engage in sexual behaviors.

The actual causes of abnormal levels of sex hormone are debatable. But all researchers agree that ageing plays an important role in production of the sex hormone steroid-binding globulin(SSBG).

Diseases, also the  risk factors associated to abnormal levels of  serum of SHBG concentrations include obesity, insulin resistance, type 2 diabetes hypothyroidism,  Cushing syndrome, nonalcoholic fatty liver disease, hypertension, ....... and androgen steroid use

The normal ranges for serum of SHBG concentrations in adults are: 

* Males: 10 to 57 nanomoles per liter (nmol/L) 

*Females (nonpregnant): 18 to 144 nmol/L

In a 8-week parallel-arm randomized controlled trial with Healthy adults (n = 42) recruited from the Boston community, including regular coffee consumers, nonsmokers, and overweight, randomized to five 6-ounce cups of caffeinated or decaffeinated instant coffee or water per day, at 4 weeks, researchers surprisingly found that
* Decaffeinated coffee drinking was associated with a borderline significantly increased levels of SHBG in women, but not in men.

*. At week 4, decaffeinated coffee decreased total and free testosterone and caffeinated coffee decreased only total testosterone in women.

*. Contrast to women participants, men consumption of caffeinated coffee displayed a significantly increased total testosterone and decreased total and free estradiol hormones.

*. The study also indicated that caffeinated coffee consumption do not exert any effect on SHBG in either men or women.

These results suggested that intake of coffee may have a strong impact in maintained normal levels of SHBG, thus reducing risk of low levels of SHBG induced higher testosterone levels in overweight women, causing androgenization and development of polycystic ovarian syndrome.

And in men, normal levels of testosterone may also have a significant contribution of healthy libido, building muscle mass, and maintaining energy levels.

Some researchers suggested that increased testosterone level for middle-aged (30 to 50 years old) and older males may also improve the physical energy, strength, stamina, mental aggressiveness which were lost in aging population.

Contrast to above differentiation, in type 2 diabetic patients, coffee and coffee caffeine showed an elevated effect as a mediator of sex hormone-binding globulin in both androgen and estrogen particularly in women in compared to the healthy young adult.

Dr. Eric L. Ding and colleagues in the study to evaluate "Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Women and Men" said, " Among women, higher plasma levels of sex hormone–binding globulin were prospectively associated with a lower risk of type 2 diabetes and " the predicted odds ratio of type 2 diabetes per standard-deviation increase in the plasma level of sex hormone–binding globulin was 0.28 (95% CI, 0.13 to 0.58) among women and 0.29 (95% CI, 0.15 to 0.58) among men".

The analysis strongly suggested that coffee regardless to types have a negative correlation with risk of diabetes through increasing levels of SHBG.

Additionally, according to the cross-sectional study of 2377 nondiabetic pre- and postmenopausal women from the E3N cohort study in a multivariate adjusted model, intake of more than 3 cup of coffee daily coffee and caffeine ≥265 mg/day were associated with an increased SHBG level distribution (<46.3 nmol/L), in compared to no risk association of decaffeinated coffee subgroup.

In other words, in low levels of SHBG nondiabetic pre- and postmenopausal in compared to healthy women, injection of caffeinated coffee increased levels of sexual hormones estrogen and testosterone

The above analysis was supported by the examination of the study during a median follow-up of 10 years of 359 postmenopausal women with newly diagnosed type 2 diabetes matched with 359 control subjects by age, race, duration of follow-up, and time of blood draw, coffee and caffeine were associated to increased levels of fee and total testosterone among postmenopausal women.

In Summary, the evidences indicated that coffee and caffeine have a extreme effect in exhibition of sex hormone estrogen and testosterone through increased lower level of SHBG in menopause women and prevented onset of type 2 diabetes without affecting the serum in healthy individuals.

Decaffeinated coffee decreased total and free testosterone through significantly increased levels of SHBG in overweight women who are at risk of diseases associated to over expression of testosterone.

And caffeinated coffee displayed a significantly increased total testosterone and decreased total and free estradiol in men.

Altogether, coffee may be considered as a function food in mediated production of sexual hormone estrogen and testosterone against diseases and syndromes caused by low levels of SSBG.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The effects of caffeinated and decaffeinated coffee on sex hormone-binding globulin and endogenous sex hormone levels: a randomized controlled trial by Wedick NM1, Mantzoros CS, Ding EL, Brennan AM, Rosner B, Rimm EB, Hu FB, van Dam RM.(PubMed)
(2) Cross-sectional association of coffee and caffeine consumption with sex hormone-binding globulin in healthy nondiabetic women by Pihan-Le Bars F1,2, Gusto G3,4,5, Boutron-Ruault MC3,4,5, Fagherazzi G3,4,5, Bonnet F1,2,3.(PubMed)
(3) Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women by Goto A1, Song Y, Chen BH, Manson JE, Buring JE, Liu S.(PubMed)

* Aloe Vera, The Herb and Plant That Inhibits Polycystic Ovarian Syndrome (PCOs)

By Kyle J. Norton

Scientists from some respectable institutes suggested that aloe vera may have a potential and profound effect in reduced symptoms, risk and treatment of polycystic ovarian syndrome(PCOs).

Polycystic Ovarian Syndrome is a condition characterized by endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women[1].

According to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21)[1].

Women with PCOs may experience some of the symptoms of irregular, oligomenorrhea or absent menstrual periods, male pattern hair growth, acne, weight gain, obstructive sleep apnea, closure of the upper airway, causing stop breathing while sleeping, difficult to conceive, anxiety, emotional disturbance, poor quality of life, menstrual cycle disturbances, depression, autonomic dysfunction, problematic eating and general psychosocial dysfunction.

Aloe Vera is species of succulent plant in the genus Aloe, belongings to the Family Xanthorrhoeaceae, native to Sudan.

The herb is most commercial cultivated due to its health benefits.

Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes,...... and elevated of cholesterol, The herb also is one of many popular herb studied in scientific ways with some conflicted results.

According to the study by Desai BN, Maharjan RH, Nampoothiri LP.  70% PCOS women have abnormal serum lipid levels (dyslipidemia) and 50% of these women are obese.

Several classes of pharmacological agents have been used to manage dyslipidemia with serious   adverse effects.

The ten main areas of chemical constituents of Aloe vera include: amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

They all work together in a synergistic way to create healing and health giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.

Application aloe vera in Charles Foster female rats induced PCOs by oral administration of non-steroidal aromatase inhibitor letrozole (0.5 mg/kg body weight, 21 days) exerts  a significant reductions of plasma triglyceride and LDL cholesterol levels, and increase of HDL cholesterol by restoring the ovarian steroid status.

 The Aloe vera gel treatment also caused reversion of abnormal estrous cyclicity, glucose intolerance, and lipid metabolizing enzyme activities.

Other study also indicated that Aloe vera gel formulation exerts a protective effect in against the PCOS phenotype by altering key steroidogenic activity. These results are attributed to phyto-components in the gel.


Dr.Pérez YY and the research team in the study of Effect of a polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice, said,  " the polyphenol-rich extract from Aloe vera. decrease significantly both body weight (p < 0.008) and blood glucose levels, calculated using the homeostasis model assessment for insulin resistance (HOMA-IR)".

Also in the confirmation of above result, the study of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models, vera leaf pulp extract suggested hypoglycaemic activity on IDDM and NIDDM rats, the effectiveness being enhanced for type II diabetes in comparison with glibenclamide.

Taken together, aloe vera can be used as secondary and therapeutic treatment in ameliorated all aspects of symptom, progression and treatment of  polycystic ovarian syndrome.

 However, further data collection performed with human consumption during the course of the investigation are necessary to complete the picture of Aloe Vera, protective effect against polycystic ovarian syndrome (PCOs) possibilities.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
[1]. The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Symptoms(Revised edition with Citations) by Kyle J. Norton
[2] Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat model by Desai BN, Maharjan RH, Nampoothiri LP.(PubMed)
[3] Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model by Maharjan R, Nagar PS, Nampoothiri L.(PubMed)
[4].  Drug-induced lupus: an update by Vasoo S.(PubMed)

* Contrary to Popular Belief, Coffee, The Beverage That Reduces Risk of Kidney Stones

By Kyle J. Norton


Food therapy is a model of diet, using foods as a form of medicine for healing purposes by centered on concepts of food that contains ingredients for treatment of diseases if eating in moderation.

However, the concept may be best  practice in diseases prevention. In treatment of ailments, food theory takes longer to ease symptoms, depending to stages of the treatment that directly address to the cause of disease.

Kidney stones is a composed of mineral salts formed in the kidneys.

The single cause of kidney stone is debatable. However, some researchers suggested that dehydration, food restriction, Rotavirus infection, over intake of calcium and supplements, ,,, and high fat intake are associated to increased risk of forming of kidney stone(4).

According to statistic, kidney stones effect over 10% of world population.

Men account for the 80% of those with kidney stones and are at risk of the forming between 30 and 40 years of age. 

About 75% of kidney stones are calcium stones.

Symptoms of kidney stone include excruciating intermittent pain, usually in the flank (the area between the ribs and hip), that spreads across the abdomen, often to the genital area and inner thigh. 

The pain tends to come in waves, gradually increasing to a peak intensity, then fading, over about 20 to 60 minutes. 

The pain may radiate down the abdomen toward the groin or testis or vulva(4).

If you experience the above symptoms, you may have kidney stones please see your doctor as soon as possible.

Epidemiological studies linking coffee and caffeine intake in risk of kidney stone formation are totally depended to daily amount of consumption.

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

According to the Warsaw Agricultural University, coffee and tea consumed daily and regularly expressed an increased risk of kidney stone by more than 80% in compared to risk of other factors, probably due to presence of oxalates if the amount of intake is over 240-ml (8-oz) daily.

In fact, in the analyzed nutritional habits of 22 stone formers with special regard to oxalate content as one of the main nutritional lithogenic factors associated with kidney stones, researchers found that risk of kidney stone increased substantially for men and women if dietary oxalate intake was over 354 mg and 406 mg, respectively.

In a total of 217,883 participants; over a median follow-up of >8 y, 4982 incident cases of kidney stone occurred studies, researchers files the following results.
1. The highest quintile of caffeine intake (95% CI: 12%, 38%) showed a significant reduced risk of developing stones by 26%, according to the Health Professionals Follow-Up Study (HPFS).
2. Caffeine inkate showed a 29 % lower risk in the NHS I cohort, and
3. and 31% lower risk in the NHS II cohort

Dr. the lead author said. "Among 6033 participants with 24-h urine data, the intake of caffeine was associated with higher urine volume, calcium, and potassium and with lower urine oxalate and supersaturation for calcium oxalate and uric acid".

Furthermore, a prospective study in investigated relation between intake of 21 different beverages and risk of symptomatic kidney stones in a cohort of 45,289 men, 40-75 years of age conducted by the Harvard School of Public Health, suggested that the risk of stone formation decreased by 10%. of the amount for each 240-ml (8-oz) serving consumed daily in caffeinated coffee.

Taking altogether, the findings demonstrated a significant effects of  caffeinated coffee intake of less than or equal to 240-ml (8-oz) in decreased risk of formation of kidney stones.

Due to small example size of above studies, further data collection on large sample size and multi centers clinical studies performed with human consumption during the course of the investigation will be necessary to complete the picture of caffeinated coffee intake of  less than 240-ml (8-oz) in reduced risk of kidney stone possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Tea and coffee as the main sources of oxalate in diets of patients with kidney oxalate stones by Gasińska A1, Gajewska D.(PubMed)
(2) Caffeine intake and the risk of kidney stones by Ferraro PM1, Taylor EN1, Gambaro G1, Curhan GC1.(PubMed)
(3) Prospective study of beverage use and the risk of kidney stones by Curhan GC1, Willett WC, Rimm EB, Spiegelman D, Stampfer MJ.(PubMed)
(4) Kidney stone by Kyle J. Norton

^^^^^Garlic, The Herb and Roots Spice That Gobbles Up Arterial Plaques Before They Can Cause Atherosclerosis

Kyle J. Norton, Master of Nutrition


Recent study suggested that patients with atherosclerosis may be benefits from adding aged garlic extract with supplement into their diet.

Atherosclerosis is a disease with plaque builds up inside the arteries, affecting the levels of oxygen in the blood as well as increasing risks of heart attacks, strokes, and peripheral vascular disease.

Atherosclerosis is a slow, progressive disease that may begin as early as childhood, caused by damage of the inner lining of the artery. However, the actual causes of the condition are  debatable.

Some researchers suggested that atherosclerosis may be caused by long term high blood pressure,
high cholesterol and triglycerides (a type of fat) in the blood. Particularly, in high levels of insulin in the blood from diabetes and in exposure to chemicals from smoking tobacco.

Patients with early stage of atherosclerosis may not experience any symptoms. However, as the disease progress, patients may have the symptoms of chest pain if the blockage occurs in an artery of the heart (coronary artery) and leg cramps during exercise or walking, if the blockage occurs in the legs.

In the advance stage, if atherosclerosis develops in the arteries or the brain, it may cause a heart attack and stroke, respectively. 

Truly, change and diet and life style not only has strong impact in prevent early onset of atherosclerosis but also inhibits progression of the condition. 

Dr.Torres N the lead scientist in the joint study of conducted by the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, said, " In many cases, diet is a major driving force, which is much easier to change and follow than other factors. It is important to establish that the first strategy to treat atherosclerosis is to modify lifestyle habits, focusing on the beneficial properties of specific nutrients" and " epidemiological, clinical and experimental studies have demonstrated that diet plays a central role in the prevention of atherosclerosis. In particular, we include information about fiber, plant sterols and stanols, niacin, taurine, olive oil, omega 3 fatty acids, antioxidants, minerals, methyl nutrients and soy"(5).

Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia, used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc.

According to the UCLA-School of Medicine, Los Angeles, the effectiveness of garlic in reduced homocysteine and progression of Atherosclerosis is the result of the changing white (wEAT) and brown (bEAT) epicardial adipose tissue(form of visceral fat deposited around the heart) in plaque stabilization.


In a placebo-controlled, double-blind, randomized trial (conducted 2005-2007), with 65 intermediate risk patients (age 60+/-9 years) treated with a capsule containing aged garlic extract (250 mg) plus Vitamin B12 (100 microg), folic acid (300 microg), Vitamin B6 (12.5 mg) and l-arginine (100 mg) daily for a 1 year, researchers found that the application exerts a favorable improvement in oxidative biomarkers, vascular function, and reduced progression of atherosclerosis.

(AGE) retard the progression of coronary calcification in patients with coronary artery disease in vitro and vivo,


Dr. Morihara N, the lead author at the joint study said, " Antiatherosclerotic activity of AGE is at least partly due to the suppression of inflammation and lipid deposition in the vessels during the early stage of atherosclerotic development".

 The experiment of a total of 157 healthy postmenopausal women (age 65 ± 6) randomized study, 500 mg isoflavonoid-rich herbal preparation, including garlic powder, reduced risk of cardiovascular disease and atherosclerosis progression through lowering high blood cholesterol.

Although garlic prevents the development of cholesterol-induced experimental atherosclerosis and possesses the direct anti-atherogenic activity, intake of garlic supplement should be taken with care to patients with ulcer.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Aged garlic extract with supplement is associated with increase in brown adipose, decrease in white adipose tissue and predict lack of progression in coronary atherosclerosis by Ahmadi N1, Nabavi V, Hajsadeghi F, Zeb I, Flores F, Ebrahimi R, Budoff M.(PubMed)
(2) Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: a randomized clinical trial by Budoff MJ1, Ahmadi N, Gul KM, Liu ST, Flores FR, Tiano J, Takasu J, Miller E, Tsimikas S.(PubMed)
(3) Aged Garlic Extract Suppresses the Development of Atherosclerosis in Apolipoprotein E-Knockout Mice by Morihara N1, Hino A2, Yamaguchi T3, Suzuki J3.(PubMed)
(4) Anti-atherosclerotic effects of garlic preparation in freeze injury model of atherosclerosis in cholesterol-fed rabbits by Sobenin IA1, Andrianova IV2, Lakunin KY3, Karagodin VP4, Bobryshev YV5, Orekhov AN6.(PubMed)
(5) Nutrition and Atherosclerosis by Torres N1, Guevara-Cruz M1, Velázquez-Villegas LA1, Tovar AR(PubMed)

* How to Restore Your Normal Levels of Testosterone, Suggested By Scientists

Kyle J. Norton, Master of Nutrition

Recent studies conducted by some academic institutes suggested that garlic may have a potential in modified the levels of serum testosterone in the blood, depending over or under expressions.

Sex hormone testosterone plays an essential role on the male reproductive physiology, including the testes, a primary productive organ in production of spermatozoa and reproductive hormones.

Furthermore, the male steroid hormone also processes a specific function in building bone and muscle mass as well as stimulating sexual desire in both sexes.

In women, testosterone is produced by the ovaries in women in small amount. The hormone also produced small quantities by the adrenal glands in both sexes.

Truly,  over expression of testosterone may cause reduced production of antioxidants, such as glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) by natural antioxidant enzymes and increased presence of free radical in the body, that can lead to cytotoxicy and weaken function of immune system.

In other words, abnormal high levels of testosterone in the blood, can alter the balance the ratio of antioxidants and free radicals in the body, leading to free radicals in induction of oxidative stress, a primarily causes of chronic ailments.

Some researchers suggested that over production of testosterone may associate to increase risk of prostate cancer, caused by oxiadtive stress effects in the prostate gland.

On the other hand, under expression of testosterone may induce symptoms of erectile dysfunction, reduced sperm count and sperm quality, decreased libido or sexual activity, infertility, reduced muscle mass...... and increased body fat.

According to the Catholic University of The Sacred Heart, hypogonadism in men also reduced production of natural antioxands that also lead to oxidative stress, in turn related with augmented cardiovascular risk(8).
In immune response, low levels of testosterone may increase immune production of white blood cells that protects the body against infection. However, prolonged period of low levels of testosterone can also lead to long term over production of white blood cells, a leading cause of auto immune diseases.

Garlic may be the next generation of natural testosterone reducer or inducer. Garlic increases production of the hormone when it is low and inhibits excessive testosterone when it is high.

Garlic (Allium sativum) is a species in the onion genus, belongings to family Amaryllidaceae, native to central Asia.

The herb  or food has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure, cholesterol, natural antibiotic, etc.

Dr. Prasad S lead research at the Industrial Toxicology Research Centre, diallyl sulfide (DAS), a constituent of garlic, exerted antioxidant activities against testosterone-induced oxidative stress in male Swiss albino mice, by significantly restored the testosterone-induced antioxidant enzymes and decreased lipid peroxidation.

The effects of garlic supplementation on protein metabolism also suggested that dietary supplementation with 0.8 g/100 g garlic alters hormones associated with protein anabolism by increasing testicular testosterone and decreasing plasma corticosterone in rats fed a high protein diet.

In the concerns of conventional medicine driamycin (ADR), a potent cytotoxic drug that cause many adverse effects on different body organs, researchers at the Faculty of Medicine, Zagazig University conducted an experience to evaluate the effect of aged garlic extract (AGE) when it is used combination with driamycin (ADR).

At the end of the study, researcher found that aged garlic extract (AGE), a garlic preparation, AGE can be used as an adjuvant therapy to resume male infertility and weak spermatogenesis induced by cytotoxic drugs or other environmental toxins through its cytoprotective and antioxidant properties.

In fact, like all natural phytochemiecals, garlic is both testosterone booster and testosterone reducer, depending to the levels of testosterone in the body and amount of garlic intake.

However, use of garlic extracts and supplements should be taken with care, as overdoses may induce liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Protective role of garlic oil against oxidative damage induced by furan exposure from weaning through adulthood in adult rat testis by El-Akabawy G1, El-Sherif NM2.(PubMed)
(2) Chronic crude garlic-feeding modified adult male rat testicular markers: mechanisms of action by Hammami I1, Amara S, Benahmed M, El May MV, Mauduit C.(PubMed)
(3) The inhibitory effects on adult male reproductive functions of crude garlic (Allium sativum) feeding by Hammami I1, Nahdi A, Mauduit C, Benahmed M, Amri M, Ben Amar A, Zekri S, El May A, El May MV.(PubMed)
(4) Modulatory effects of diallyl sulfide against testosterone- induced oxidative stress in Swiss albino mice by Prasad S1, Kalra N, Shukla Y.(PubMed)
(5) Testosterone and oxidative stress: the oxidation handicap hypothesis by Carlos Alonso-Alvarez,1,* Sophie Bertrand,1 Bruno Faivre,2 Olivier Chastel,3and Gabriele Sorci1,2(The Royal Society Publicizing)
(6) https://www.stronghealthtips.com/garlic
(7) Effects of testosterone on antioxidant systems in male secondary hypogonadism by Mancini A1, Leone E, Festa R, Grande G, Silvestrini A, de Marinis L, Pontecorvi A, Maira G, Littarru GP, Meucci E(PubMed)
(8) The impact of aged garlic extract on adriamycin-induced testicular changes in adult male Wistar rats by Nasr AY(PubMed)