Detoxification: How to Detox and Nourish Your Body with Nutritional Supplements

Western diet bears high saturated fat, trans fat, and other harmful substances such as sugar, caffeine, pesticides, additive substances, and less in fruits and vegetables.

These types of harmful substances are toxic.

Our body's detoxifying functions try to get rid of them everyday, when they fail, toxins accumation can cause disruption of hormone production, damage of our body's detoxification organs and weakening of our immune system that can lead to hormone imbalance and chronic illnesses.

Nutritional supplements are also known as dietary supplement that provide additional nutrients to the body including vitamins, minerals, proteins, amino acids or other nutritional substances.

Although a balanced and varied diet is the best source of essential vitamins and minerals. However,  nutrient deficiencies occur, even in populations of countries with plentiful food supplies.

Particularly, American diet is a complete opposite to resemblance of what experts recommend for fruit, vegetables, and whole grains, which can contribute to important sources of an array of vitamins and minerals.

Therefore, people who follow the American diet may require to take additional nutrients from supplementation. 

Dr. Elizabeth Ward said, " With time, deficiencies in one or more micronutrients may lead to serious health issues. A common reason people take multivitamin and mineral (MVM) supplements is to maintain or improve health, but research examining the effectiveness of MVMs in the prevention of certain chronic conditions is ongoing"(4).

Nutritional Supplements That Detox and Nourish Your Body include

1. Pumpkin seed
Pumpkin seeds contain high amounts of alpha carotene and beta carotene that are antioxidants(1) that help the immune system(2) in fighting inflammation caused by over expression of free radicals(1),

ROS is best know to alter cells DNA through cytotoxicity effect in induction of cancers(3).

Dr. A K the lead scientist in the evaluation of the effects of pumpkin seed oils suggested that Cucurbita maxima seeds oil (CSO (100 mg/kg body weight)) injected to high fat diet (HFD)-induced obese rats for 30 days causes significant change of lipid metabolic enzymes and inflammatory markers through ameliorateing the HFD-induced obesity by altering the enzymes and mRNA expressions important to lipid metabolism(5).

Some researchers suggested that pumpkins seed oil can detox the body through eliminating toxins secreted by parasites and parasites, such as adult tapeworms of Taenia spp. that cause infection in the upper small intestine of humans(6)

2. Chlorella
Chlorella is a fresh water algae containing a variety of vitamins, minerals and substances.

The algae processes abundant antioxidant that strengthen our brain functions by removing metals accumulated(3),

Chlorella also contains beta carotene, amino acid, lutein, the powerful antioxidants that help to remove calcium stuck in arterial wall, make the arteries elastic(7), repairing the DNA damage of cells(3), as well as detoxifying our body toxins and against the forming of cancerous free radicals(3).

Dr. Mercola found that chlorella may be effective in removed mercury from your tissues(8).
3. Chrysin
Chrsysin is a bioflavonoid that regulates the production of growth hormones(10), increasing alertness, memory and reduce stress and anxiety(11).

For example administration of chrysin altered levels of testosterone in patients with enlarge prostate that restores glutathione and suppresses superoxide dismutase and catalase activities, and elevated lipid peroxidation(10)
Injection of chrysin at the total dose of 160 mg/kg strongly suppresses the growth of colon cancer xenograft in mice, through cytotoxic activities in increased cell cycle arrest and decreased tumor cells proliferation according to science direct(9),

4. Cinnamon bark
Cinnamon bark is an evergreen tree belongings to the family Lauraceae.

Besides having proven record in treating diabetes and insulin resistance(12), it is also a powerful anti-inflammation and antioxidant(13), many times more powerful than vitamin C that helps to strengthen the immune system(3) and fighting off the forming of free radicals(13) in induction of chronic illness.

The supplement also has a profound effect in detox liver caused by over expression of ROS(14) induced by toxin accumulation.

5. DHEA
DHEA is a natural hormone that enhances the function of the brain(15) and promote longevity(16). caused by low levels of growth hormones as aging progress.

Deficiency of DHEA causes weakening of immune system(17) and skin problems(18) as well as degeneration of brain resulting in Alzheimer's and Parkinson's diseases(17).

6. NADH
The shortened name of nicotinmide adenine dinucleotide, also called co enzyme Q1, is a powerful antioxidant that not only rejuvenates(19) our body's cell and help fight against early aging(19), but also helps to reduce the accumulation of heavy metals(20), improve memory, reduce stress, anxiety, depression and provide energy for function of the brain(21).

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Sources
(1) Characteristics of antioxidant activity and composition of pumpkin seed oils in 12 cultivars by Nawirska-Olszańska A1, Kita A, Biesiada A, Sokół-Łętowska A, Kucharska AZ(PubMed)
(2) Preventing Ralstonia solanacearum adhesion with glycans from cashew, cocoa, coffee, pumpkin, and tomato seed extract by Rachmaninov O1, Zinger-Yosovich KD, Gilboa-Garber N(PubMed)
(3) Free radicals, metals and antioxidants in oxidative stress-induced cancer by Valko M1, Rhodes CJ, Moncol J, Izakovic M, Mazur M(PubMed)
(4) Addressing nutritional gaps with multivitamin and mineral supplements by Elizabeth Ward(PMC)
(5) Reversal of high fat diet-induced obesity through modulating lipid metabolic enzymes and inflammatory markers expressions in rats by A K1,2, Uddandrao VVS1, Parim B3, Ganapathy S1, P R N1, Kancharla SC4, P R1, K S1, Sasikumar V(PubMed)
(6) Usefulness of pumpkin seeds combined with areca nut extract in community-based treatment of human taeniasis in northwest Sichuan Province, China by Li T1, Ito A, Chen X, Long C, Okamoto M, Raoul F, Giraudoux P, Yanagida T, Nakao M, Sako Y, Xiao N, Craig PS(PubMed)
(7) Vitamin C, Vitamin E, Selenium, and β-Carotene and Other Carotenoids: Overview, Antioxidant Definition, and Relationship to Chronic Disease(Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds)
(8) Chlorella: Use This Superfood to Help Remove Mercury From Your Tissues in Weeks By Dr. Mercola
(9) Signal Therapy by Hiroshi Maruta1, Toshiro Ohta2, in Complementary and Alternative Therapies and the Aging Population, 2009(Science Direct)

(10)Chrysin attenuates testosterone-induced benign prostate hyperplasia in rats by Shoieb SM1, Esmat A1, Khalifa AE1, Abdel-Naim AB(PubMed)

(11) Neuroprotective effects of chrysin: From chemistry to medicine by Nabavi SF1, Braidy N2, Habtemariam S3, Orhan IE4, Daglia M5, Manayi A6, Gortzi O7, Nabavi SM(PubMed)

(12) Efficacy of cinnamon in patients with type II diabetes mellitus: A randomized controlled clinical trial. by Zare R1, Nadjarzadeh A2, Zarshenas MM3, Shams M4, Heydari M(PubMed)

(13) Anti-inflammatory activity of cinnamon (C. zeylanicum and C. cassia) extracts - identification of E-cinnamaldehyde and o-methoxy cinnamaldehyde as the most potent bioactive compounds by Gunawardena D1, Karunaweera N, Lee S, van Der Kooy F, Harman DG, Raju R, Bennett L, Gyengesi E, Sucher NJ, Münch G(PubMed)

(14) Aldo-keto reductase 1 family B7 is the gene induced in response to oxidative stress in the livers of Long-Evans Cinnamon rats by Jia G1, Takahashi R, Zhang Z, Tsuji Y, Sone H.(PubMed)

(15) Effect of dehydroepiandrosterone (DHEA) on memory and brain derived neurotrophic factor (BDNF) in a rat model of vascular dementia by Sakr HF1, Khalil KI, Hussein AM, Zaki MS, Eid RA, Alkhateeb M(PubMed)

(16) Dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and longevity by Schwartz AG1, Pashko LL(PubMed)

(17) A review of dehydroepiandrosterone (DHEA).by Shealy CN(PubMed)

(18) [Psoriasis: A general disease? Can psoriasis be explained biochemically?].[Article in German] by Goerz G(PubMed)

(19) NAD⁺ in aging, metabolism, and neurodegeneration by Verdin E(PubMed)

(20) NADH induces iron release from pea seed ferritin: a model for interaction between coenzyme and protein components in foodstuffs by Lv C1, Bai Y, Yang S, Zhao G, Chen B(PubMed)

(21) Crosstalk of Signaling and Metabolism Mediated by the NAD(+)/NADH Redox State in Brain Cells by Winkler U1, Hirrlinger J(PubMed)

Infectious Diseases Caused By Over Growth of Candida - The Anti Intestinal Dysbiosis Therapies

By Kyle J. Norton, Scholar, Master of Nutrition

Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.

Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).

Dysbiosis is medical condition in the gastrointestinal tract, caused by either intestinal bacterial overgrowth (SIBO) or small intestinal fungal overgrowth.

Some researchers suggested, " dysbiosis may not be the most important factor, rather the products of interaction between diet and the microbiome and "High-protein diets are thought to result in the production of carcinogenic metabolites from the colonic microbiota that may result in the induction of neoplasia in the colonic epithelium"(1).

Dr. Sara Gottfried MD in the article of " Dysbiosis Decoded: Symptoms, Why You Get It, and Link to Autoimmunity, Breast Cancer, Irritable Bowel Syndrome, Plus Other Common Conditions" suggested that if you experience 5 of below symptoms, you may be infected by intestinal fungal overgrowth dysbiosis(a).

Here is the list provided by the doctor(a)

* Frequent gas or bloating on most days of the week
* Cramping, urgency, and/or mucus in your poop once per week
* Brain fog, anxiety, or depression
* Food sensitivities
* Missing micronutrients
* Chronic bad breath
* Loose stool, diarrhea, constipation, or a combination
* Diagnosis of Irritable Bowel Syndrome (IBS)
* History of “stomach bugs,” gastroenteritis, and/or food poisoning
* History of prolonged antibiotics such as for acne or sinusitis
* Carbohydrate intolerance, particularly after eating fiber and/or beans
* Fatigue or low energy
* Use of anti-acids for heartburn, reflux, or hiatal hernia?
* Autoimmunity, or an autoimmune condition such as Hashimoto’s thyroiditis, psoriasis, or multiple sclerosis
* Sinus congestion

The Therapies that Inhibit Intestinal Dysbiosis Caused by Over Growth of Candida

1. Probiotics
Probiotics are live micro-organisms conferred a health benefit on the host and found to be benefits the digestive system(363), including inflammatory bowel disease(364).

According to Dalian Medical University, there are many causes of dysbbiosis, such as prolonged period intake of antibiotic used widely in conventional medicine for treatment of bacterial infection(365).

Dr. McFarland LV at the University of Washington said that the use of probiotics to restore the balance of undisturbed microbiota in healthy individual is most effectively than patients with postdisruptive event and probiotic therapy and pre-existing disrupted microbiota and then postprobiotic therapy(366).

2. Prebiotics
Prebiotic, the non-digestible food ingredients and the most prevalent forms of prebiotic is nutritionally classed soluble fiber(367), including Galactooligosaccharide, stimulated the production of number and/or activity of bifidobacteria and lactic acid bacteria(368) and/or activity in the digestive system(369) in ways claimed to be beneficial to health of the host, by counteracting to the overgrowth of bad bacteria(371)(372), including candida albicans.


3. High fiber foods
Fiber is the indigestible portion of plant foods having two main components soluble and insoluble fiber, consisted non-starch polysaccharides such as arabinoxylans( woods and cereal grains), cellulose(a linear chain of several hundred to many thousands of linked D-glucose unit) and many other plant component.

While it is beneficial for alleviating symptoms of irritable bowel syndrome(373), such as diarrhea and/or constipation and abdominal discomfort, it is also a prebiotic(374) which is beneficial to health of the host by enhancing the production of good bacteria in the gastrointestinal tract(375) and counteracting to the overgrowth of bad bacteria, including candida albicans.

4. Avoid allergic foods
Eating allergic foods often causes symptoms of digestive disorders(376), including gas, stomach pains, diarrhea, constipation, bloating, etc. as allergen-producing L. lactis strains(377) induced imbalance of bacteria in digestive systems, that can lead to overgrowth of bad bacteria quickly.

5. Regular intake of Allium satvum (garlic)
Allium satvum is a species in the onion family Alliaceae, native to Central Asia.

Garlic beside is best known for its effectiveness in treating hypertension(378), hyper cholesterol(379), blood thinner(380) and cancer(381), it also contains high amount of phytoncides that inhibits the growth of microorganisms(382) and phytoalexin called allicin which processes anti-oxidative(383)(384) and anti-microbial effects(385).

The herb would be helpful to keep a healthy digestive system and prevent the growth out of control of bad bacteria.

6. Enhances immune system
Living healthy and eating healthy foods such as such as whole grain, fresh fruits, vegetables, nuts and seeds, beans and legumes provide your body with necessary nutrients, including antioxidants, vitamins and minerals, that not only optimizes the digestive absorption but also enhances the immune system(386)(387)in fighting against inflammation(389) and infection(388) caused by virus and bacteria.

7. UVC therapy
Light therapy is considered as a type of treatment of exposing to daylight or to specific wavelengths of light, used to accelerate wound healing(390), hair growth, and improved blood properties(391).

Statistical analysis found in vitro candida strains were sensitive to UVC(392) and photodynamic therapy with malachite green(393).

8. Exercise
Exercise is important in enhancing the immune system(394) to reduce the likelihood of getting yeast infections(385) but also put your body in a better position to fight off the candida.

9. Reduce stress
Signs of stress may be cognitive, emotional, physical or behavioral, signs of poor judgment, a general negative outlook, can depress the immune system(395) and impair the digestive system(396), causing psoriasis(397), a chronic autoimmune disease and gastrointestinal tract infection(396), leading to more favorable conditions for unhealthy candida to multiple.


10. Specific sexual practices and sexual behavior
A study in USA revealed that a 75% percentage of women have had candida yeast overgrowth at some points in their lives in comparison to only 45% of men. Sexual practices such as receptive anal and oral sex and douching increase the risk of infectious candida(398).

Risk of vulvovaginal candidiasis also increases in women who have sex with several women partners(399)(400). If you noticed changes in your body such as thick, cheese-like discharges, pain during sex and an itchy burning sensation, check with your doctor immediately.

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Sources
(a) Dysbiosis Decoded: Symptoms, Why You Get It, and Link to Autoimmunity, Breast Cancer, Irritable Bowel Syndrome, Plus Other Common Conditions By Sara Gottfried MD
(1) Dysbiosis of the gut microbiota in disease by Simon Carding,1,2 Kristin Verbeke,3 Daniel T. Vipond,1,2 Bernard M. Corfe,4,5,* andLauren J. Owen(PMC)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(363) Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease by Lewis SJ1, Freedman AR(PubMed)
(364) Review article: yeast as probiotics -- Saccharomyces boulardii by Czerucka D1, Piche T, Rampal P.(PubMed)
(365) Determining the role of a probiotic in the restoration of intestinal microbial balance by molecular and cultural techniques by Shoaib A1, Dachang W1, Xin Y2.(PubMed)
(366) Use of probiotics to correct dysbiosis of normal microbiota following disease or disruptive events: a systematic review by McFarland LV1(PubMed)
(367) Fiber and prebiotics: mechanisms and health benefits by Slavin J1(PubMed)
(368) Isomer-specific consumption of galactooligosaccharides by bifidobacterial species by Peacock KS1, Ruhaak LR, Tsui MK, Mills DA, Lebrilla CB(PubMed)
(369) [Vegetable fiber (II). Diseases of the digestive system]. [Article in Spanish] Mur de Frenne L, Tosao Sánchez A, Fleta Zaragozano J.(PubMed)
(370) Fiber and prebiotics: mechanisms and health benefits by Slavin J1.(PubMed)
(371) Beneficial Bowel Bacteria – Our Neglected Friends (The Mcdougal newsletter)
(372) In vitro fermentation of lactulose by human gut bacteria by Mao B1, Li D, Zhao J, Liu X, Gu Z, Chen YQ, Zhang H, Chen W.(PubMed)
(373) The role of fiber in the treatment of irritable bowel syndrome: therapeutic recommendations by Zuckerman MJ1.(PubMed)
(374) Dietary roles of non-starch polysaccharides in human nutrition: a review by Kumar V1, Sinha AK, Makkar HP, de Boeck G, Becker K.(PubMed)
(375) Fermentable non-starch polysaccharides increases the abundance of Bacteroides-Prevotella-Porphyromonas in ileal microbial community of growing pigs by Ivarsson E1, Roos S2, Liu HY1, Lindberg JE1.(PubMed)
(376) Digestibility of fibre sources and molecular weight distribution of fibre fractions in ileal digesta of growing pigs by Ivarsson E1, Andersson R, Lindberg JE.(PubMed)
(376) Egg proteins as allergens and the effects of the food matrix and processing by Benedé S1, López-Expósito I, Molina E, López-Fandiño R.(PubMed)
(377) Modulation of peanut-induced allergic immune responses by oral lactic acid bacteria-based vaccines in mice by Ren C1, Zhang Q, Wang G, Ai C, Hu M, Liu X, Tian F, Zhao J, Chen Y, Wang M, Zhang H, Chen W.(PubMed)
*378) Effects of aged garlic extract on left ventricular diastolic function and fibrosis in a rat hypertension model by Hara Y1, Noda A, Miyata S, Minoshima M, Sugiura M, Kojima J, Otake M, Furukawa M, Cheng XW, Nagata K, Murohara T.(PubMed)
(379) Effects of garlic oil on interleukin-6 mediated cardiac hypertrophy in hypercholesterol-fed hamsters. Hsieh YL1, Pai P, Ho TJ, Chung LC, Cheng YC, Wu CH, Fan MJ, Day CH, Shen CY, Huang CY.(PubMed)
(380) Anticoagulant activity of select dietary supplements by Stanger MJ1, Thompson LA, Young AJ, Lieberman HR.(PubMed)
(381) Onion and garlic use and human cancer by Galeone C1, Pelucchi C, Levi F, Negri E, Franceschi S, Talamini R, Giacosa A, La Vecchia C.(PubMed)
(382) [Effect of phytoncides on the bacteria isolated from patients with respiratory pathology]. [Article in Russian] by Manastyrskiĭ RIa, Demkevich LI, Sibirnaia RI, Beliakova OI, Iukhimenko IE.(PubMed)
(383) Antioxidant health effects of aged garlic extract by Borek C1.(PubMed)
(384) Aged garlic extract and its constituents inhibit Cu(2+)-induced oxidative modification of low density lipoprotein by Ide N, Nelson AB, Lau BH.(PubMed)
(385) Allicin enhances host pro-inflammatory immune responses and protects against acute murine malaria infection by Feng Y1, Zhu X, Wang Q, Jiang Y, Shang H, Cui L, Cao Y.(PubMed)
(386) Effects of increased wholegrain consumption on immune and inflammatory markers in healthy low habitual wholegrain consumers by Ampatzoglou A1, Williams CL, Atwal KK, Maidens CM, Ross AB, Thielecke F, Jonnalagadda SS, Kennedy OB, Yaqoob P.(PubMed)
(387) Increased whole grain consumption does not affect blood biochemistry, body composition, or gut microbiology in healthy, low-habitual whole grain consumers. Ampatzoglou A1, Atwal KK1, Maidens CM1, Williams CL1, Ross AB2, Thielecke F3, Jonnalagadda SS4, Kennedy OB1, Yaqoob P5.(PubMed)
(388) Colonization and infection of the skin by S. aureus: immune system evasion and the response to cationic antimicrobial peptides by Ryu S1, Song PI2, Seo CH3, Cheong H4, Park Y5.(PubMed)
(389) Obesity, inflammation and the immune system by de Heredia FP1, Gómez-Martínez S, Marcos A.(PubMed)
(390) Ultraviolet Radiation in Wound Care: Sterilization and Stimulation by Gupta A1, Avci P2, Dai T3, Huang YY4, Hamblin MR5.(PubMed)
(391) In vitro and in vivo characterization of ultraviolet light C-irradiated human platelets in a 2 event mouse model of transfusion by Zhi L1, Chi X, Vostal JG.(PubMed)
(392) Ultraviolet-C light for treatment of Candida albicans burn infection in mice by Dai T1, Kharkwal GB, Zhao J, St Denis TG, Wu Q, Xia Y, Huang L, Sharma SK, d'Enfert C, Hamblin MR. (PubMed)
(393) Antimicrobial photodynamic therapy: photodynamic antimicrobial effects of malachite green on Staphylococcus, enterobacteriaceae, and Candida by Junqueira JC1, Ribeiro MA, Rossoni RD, Barbosa JO, Querido SM, Jorge AO.(PubMed)
(394) Position statement. Part one: Immune function and exercise by Walsh NP1, Gleeson M, Shephard RJ, Gleeson M, Woods JA, Bishop NC, Fleshner M, Green C, Pedersen BK, Hoffman-Goetz L, Rogers CJ, Northoff H, Abbasi A, Simon P.(PubMed)
(395) Psychoneuroimmunology. Fact or fiction? by Sali A1.(PubMed)
(396) Hypoxic macrophages impair autophagy in epithelial cells through Wnt1: relevance in IBD by Ortiz-Masiá D1, Cosín-Roger J1, Calatayud S1, Hernández C2, Alós R3, Hinojosa J3, Apostolova N4, Alvarez A1, Barrachina MD1.(PubMed)
(397) Chronic stress experience and burnout syndrome have appreciable influence on health-related quality of life in patients with psoriasis by Breuer K1, Göldner FM, Jäger B, Werfel T, Schmid-Ott G.(PubMed)
(398) Higher-risk behavioral practices associated with bacterial vaginosis compared with vaginal candidiasis by Bradshaw CS1, Morton AN, Garland SM, Morris MB, Moss LM, Fairley CK.(PubMed)

(399) Vulvovaginal candidiasis in women who have sex with women by Bailey JV1, Benato R, Owen C, Kavanagh J.(PubMed)
(400) Bacterial vaginosis in lesbians and bisexual women by Bailey JV1, Farquhar C, Owen C.(PubMed)(401) Traditional Chinese Medicine for Candidiasis(Traditional Chinese medicine information page)

Beet, The Anti Liver Cancer Cells Root Veggie

Kyle J. Norton


Beet root, one of popular functional vegetable may hold a key in reduced risk and treatment of liver cancer, a respectable study opinionated.

Liver cancer is a medical condition characterized by cell growth irregularly and uncontrollably in liver tissue.

At the late stage, the cancerous cells may travel a distance away from the original site to infect other healthy tissues.

According to statistic, approximately, 40000 adults in the United States will be diagnosed with primary liver cancer every year.

The disease also causes annual death of 17,000 men and 8,000 women.

The 5-year survival rate of people who are diagnosed with liver cancer is 18%.

However, the 5 years of early diagnosis survival rate is 31%.

Birth defect, alcohol abuse and chronic liver infection are most causes of liver cancer, diabetes and hemochromatosis also are associated to increased risk of the chronic disease.

Most common symptoms of liver cancer include jaundice, abdominal pain unexplained weight loss, an enlarged liver, fatigue,.... and back pain.

However, most people with liver cancer do not experience any symptoms until the advance stage.

Therefore, people with higher risk o.f liver cancer, such as excessive alcohol consumption should have their liver checked annually.

Beet, best known as the beetroot or garden beet, belongings to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.

According to the Howard University, in liver tumor induced by injection of tumor initiation with N-nitrosodiethylamine (DEN, 30 mg/kg) in mice model, mice group treated with oral administration of 0.0025% betanin isolated from beet or beet root, exerted a very significant effect on both the incidence and multiplicity of the liver tumors.

Dr. Kapadia GJ, the lead author suggested, betanin, the major chemical compound found in beet root is an effective cancer chemopreventive agent in mice.

Regular consumption of the vegetable may ameliorate against the incidence of cancers, including liver cancer.

In the findings of natural food in compared to conventional anticancer drugs in high resistance HepG2 liver cancer cells, researchers at the University of Urbino "Carlo Bo" found that natural compound Vitexin-2-O-xyloside (XVX) and avenanthramides (AVNs) isolated from beet, exhibited antiproliferative and pro-apoptotic effects by sulforhodamine B method, and caspase activity assays, respectively.

The study also showed the inhibition of the liver cell line may be a result of the phytochemicals activities in activation of proteins in regulated progression of apoptosis and prevented gene in over expression of pro cancer cell survival.

More importantly, the efficacy of beetroot in reduced incidence of early onset of liver cancer may also attribute to the antioxidant property in prevention of over production of free radical which was known as an independent risk factor in inducing liver cancer, measured by Cellular antioxidant activity (CAA) assay.

Other, in the examine of the effect of betaxanthins and betacyanins efficacy in treatment of various cancers, postulated that the isolated phytochemicals may be a potential natural agents in inhibited cancer cell lines intrinsically and extrinsically by induced apoptosis.

More importantly,  Vitexin-2- O-xyloside, betaxanthins and betacyanins combination with conventional anticancer drugs may be a future treatment in reduce conventional anticancer drugs toxicity and overcome the expression of multidrug resistance of cancer cells.

Collectively, these findings may suggested that intake of functional food - beet root regularly may reduce risk and treatment of liver cancer.

However, further data collection on studies performed with human consumption during the course of the disease will be necessary to complete the picture of beet  anti liver cancer possibilities.

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Holistic System In Existence That Will Show You How To
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Author Biography
Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot by Kapadia GJ1, Azuine MA, Sridhar R, Okuda Y, Tsuruta A, Ichiishi E, Mukainake T, Takasaki M, Konoshima T, Nishino H, Tokuda H.(PubMed)
(2) Antiproliferative activity of vitexin-2-O-xyloside and avenanthramides on CaCo-2 and HepG2 cancer cells occurs through apoptosis induction and reduction of pro-survival mechanisms by Scarpa ES1, Antonini E1, Palma F1, Mari M1, Ninfali P2.(PubMed)
(3) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES1.(PubMed)

The Anti Migraine Diet That Works, Scientists Say

Kyle J. Norton, Master of Nutrition


Migraine is one most common headaches characterized by chronic neurological disorder of moderate to severe headaches, and nausea that usually develop gradually over 5–20 minutes and last for less than 60 minutes.

The condition effects over 15% population in US, as a result of the change in the brain and its surrounding blood vessels.

Some researchers suggested that dietary and gastrointestinal issues have a significantly impact in clinical expression of migraine, including gut dysfunction during and between attacks, food triggers, increase in migraine with obesity, comorbid GI and systemic inflammation influenced by diet, and specific food allergies such as dairy and gluten(1).

And, care givers and practitioners not only need to encourage migraineurs to seek consistency in their lifestyle behaviors, and environmental exposures, as a way of avoiding sudden changes that may precipitate attacks(1) but also must remind them to avoid suspected foods that trigger, consistently(1).

Believe it or not, according to statistic and research, migraine headaches have caused substantial individual impact on work productivity and increased a significantly societal burden to direct medical costs, lost work time(2).

And in more severe persistent migraine, the lost work time costs greatly exceed medical care costs(2).

Most common symptoms during migraine attacks include pain on one side or both sides of the head and pain that feels throbbing or pulsing.

Some patients during attacks also experience symptoms of  light,  sounds, smells and touch sensitivity.

In some cases, the attack also induces symptoms of nausea and vomiting. blurred vision..... and  lightheadedness.

Diet for Migraine headache
Certain diet may trigger the attack of migraine due to allergic reaction in certain people, but the below suggested foods may be helpful to people who experience migraine with no allergic effects.
1. Water
Water, an essential for the body’s proper functioning, and dehydration may trigger the migraine attack.

In a study of 50 migraineurs were asked if insufficient fluid intake could provoke their migraine attacks conducted by The City of London Migraine Clinic, researchers found that twenty replied "yes," 7 were doubtfully positive, and 23 said "no."

In addition  of 14 of 45 migraineurs at a meeting of the British Migraine association (UK) also recognized fluid deprivation as one of their migraine triggers.(E.C.1).

Therefore, adding fluid deprivation to migraine patient may reduce the numbers of migraine attacks.

2. Fish oil 
Omega-3 PUFA, from fish oil-eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) process anti-inflammatory properties of which are useful in the management of inflammatory and autoimmune diseases, including rheumatoid arthritis, Crohn's disease, ulcerative colitis, psoriasis, lupus erythematosus, multiple sclerosis and migraine headaches.(E.C.2)

3. Broccoli
Broccoli is a very good source of magnesium and a good source of calcium.

Magnesium, plays an essential in many intracellular processes and in migraine pathogenesis. Low levels of magnesium may promote cortical spreading depression, hyperaggregation of platelets, affect serotonin receptor function, and influence synthesis and release of a variety of neurotransmitters of which can trigger migraine headache(B.A.8)

4. Sardines
Sardines contain measurable amount of Omega 3 fatty acid, calcium and CoQ10 with function in  in reduced frequency of migraine headache (E.B.3)(E.B.2)

5. Spinach
Spinach is an excellent source of both calcium, magnesium, vitamin B2 (riboflavin).

Riboflavin therapy supplemented may be appropriate alternatives in patients with migraine disorder as it significant decreases in headachefrequency, intensity, duration and medication intake (E.C.7)

6. Mustard Greens
The World's Healthiest Foods recommends mustard greens as an excellent source of calcium and a very good source of magnesium which is important in preventing and treating migraine headache (See E.B.1 and 2)

7. Fish
Beside rich in Omega 3 fatty acids, all fish contain more or less DL-phenylalanine, an essential amino acid of which is important for our body converts phenylalanine to tyrosine, another amino acid then to epinephrine and norepinephrine, which are important brain chemicals called neurotransmitters.

Some researchers suggest that DL-phenylalanine(DLPA) appears to potentiate pain relief and ease depression in patients receiving opiates for chronic non-malignant pain(E.C.9).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(E.C.1) http://www.ncbi.nlm.nih.gov/pubmed/15953311
(E.C.2) http://www.ncbi.nlm.nih.gov/pubmed/12480795
(E.C.7) http://www.ncbi.nlm.nih.gov/pubmed/21197315
(E.C.9) http://www.ncbi.nlm.nih.gov/pubmed/10998643
(B.A.8) http://www.ncbi.nlm.nih.gov/pubmed/22426836
(E.B.2) http://www.ncbi.nlm.nih.gov/pubmed/2948651
(E.B.3) http://www.ncbi.nlm.nih.gov/pubmed/17355497
(1) https://www.ncbi.nlm.nih.gov/pubmed/24068338
(2) https://www.ncbi.nlm.nih.gov/pubmed/26563803

Green Tea, a Drink That Relieves Acute and Chronic Constipation

Kyle J. Norton

Green tea may have a therapeutic and positive effect in prevention and treatment of acute and chronic constipation, some scientists suggested.

Constipation, a most common complain of people of all age in US,  is a condition characterized by infrequent bowel movements.

People with the condition may experience symptoms of abdominal pain, bloating, and particularly in feeling of incompletely passed the bowel movement.

In case of chronic constipation, according to Mayo Clinic, symptoms may also include passing fewer 3 stools per week, having lumpy or hard stools, straining to have bowel movements, feeling as though there's a blockage in your rectum,.... and. feeling as though you can't completely empty the stool from your rectum(5).

According to general belief, constipation is associated to poor diet and physical inactive lifestyle.

In other words, eating too much junk food and lack of exercise are the common causes of constipation.

Some researchers suggested, "Difficulties with bowel function are common and may be due to several causes including slow colonic transit and obstructed defecation" and "Improvements over the past few years in our understanding of the complex process of defecation, along with the increasing use of radiological and anorectal physiology studies, have led to improved treatment results"(6).

Slow colonic transit is the  process of uncoordination of the enteric neurons and gastrointestinal muscle and stool can not moves through the small and large intestine(6).

Obstructed defecation, is a condition of difficult emptying the rectum, occurred even with frequent visits to the toilet and even with passing soft motions.(6).

Truly, besides the common causes of unhealthy diet and life style, risk factors of constipation also include

* Socioenvironmental factors

 According to a territory-wide cross-sectional questionnaire survey conducted in 2318 Hong Kong Chinese elementary school students. socioenvironmental factors are associated with childhood constipation, including children who lived with neither parent, had inadequate company of parents at home, refused to pass bowel movements in school, spent long hours doing homework, had inadequate sleep, and had decreased fiber intake and frequent consumption of fast food(7). 

* Hormonal factors

Constipation may be caused by hormone imbalance, such as disturbance in the serotonin transmission system, which results in a cascade of alterations in a number of gut neuroendocrine hormones/transmitters(8). 

* Medication factors

Certain medication intake also may induce the condition, including opoid pain relievers like (Morphine, Codeine), anti-cholinergic (Atropine), Trihexiphenidyl Antispasmodics (Dicyclomine),........ and Tricyclic antidepressants(Amytriptyline).

According to statistic, constipation affects 1/6 people over 12 years old in Canada.

Green tea, is a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome", according to traditional Chinese medicine.

In the examine the effects of Pu-erh tea on constipation in ICR mice induced by carbon injection researchers found that mice in control group without administrated Pu-erh green tea expressed a significant weight loss, food and water intake in compared to experiment group.

In compared to first black stool time of normal group of 90 min, control (injection of carbon) of 221 min and bisacodyl treatment group (100 mg/kg in control group) of 118 min, mice in control group treated with green tea at doses of 200, 400 and 800 mg/kg showed an improved stool passing time of 178, 155 and 139 min, respectively.

Importantly, application of green tea Pu-erh also expressed a strong increase of serum levels of

*. Motilin (MTL) in the blood steam in stimulated the contraction of the fundus and antrum and accelerated gastric emptying;
*. Gastrin, a peptide hormone in stimulated secretion of gastric acid (HCl) by the parietal cells of the stomach in improved gastric motility;
*. Endothelin (ET), a peptide hormone with function in contraction of rat stomach strips, rat colon, and guinea pig ileum;
*. Acetylcholine enzyme (AchE) chemical released by motor neurons of the nervous system in order to activate muscles;
* Substance P (SP) a amino-acids peptide in induction of rapid contraction of the smooth muscle of the digestive tract and
*. Vasoactive intestinal peptide (VIP), a potent vasodilator, in regulated smooth muscle activity and blood flow in the gastrointestinal tract.

And decrease of somatostatin (SS) hormone in reduced gastric acid secretion and emission of gastrointestinal hormones, such as gastrin.

Additionally, in comparison of 2 types of commonly used osmotic laxative polyethylene glycol (PEG), namely PEG with electrolytes mixed with water and PEG without electrolytes mixed with tea or other sources such as juice and coffee for taste, researchers at the Pirkanmaan Erikoislääkäripalvelu conducted a randomized, double-blind, parallel-group study at ten private assisted-living facilities or communal nursing homes in Finland.

Selected patients were.required to have used isotonic PEG at a stable dose without any other treatment for constipation (except for Plantago ovata seeds) for at least 2 weeks prior to a run-in period and randomly assigned receive hypotonic PEG or continued to receive isotonic PEG, both dissolved in water, 12 g once or twice daily or once every other day, for 4 weeks.

At the end of the experience periods, researchers found that the mean (SD) weekly stool frequencies are not different in both hypotonic and isotonic PEG groups, although soft or normal stool consistency of 70% was higher in the hypotonic PEG group in compared to 52% in isotonic PEG group.


Moreover, both products are considered safe without inducing stool straining or gastrointestinal symptoms, although level of sodium was statistically and significantly lower in the hypotonic PEG group at the last day of testing of the study in compared to other group.

Dr. Seinelä L, after taking into account of other co factors said, "Both treatments appear safe, well tolerated and, when dissolved in water, well accepted by the majority of the patients. When desired, switching from isotonic to hypotonic PEG can safely take place in elderly individuals without compromising efficacy".

However, a total of 1,705 female Japanese dietetic students aged 18-20 years and free of current disease studies suggested the intake of tea is associated to constipation(3) without mentioning types of tea used in the surveys.

According to the theory of traditional Chinese medicine, green tea is yin in nature with function in relieved indigestion and smoothed bowel movements through promotion of fluid production(4) and constipation is a result of over expression of yang or deficiency of yin, therefore, we do believe, the tea mentioned in the study were red, black or herbal tea with yang sufficiency.

Taken together, green tea may be considered as a functional food for prevention and treatment of constipation.

Intake of green tea extracts should be taken with exceptional care due to toxicity reported in medical literature.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Component analysis of Pu-erh and its anti-constipation effects by Li G1, Wang Q1, Qian Y1, Zhou Y1, Wang R1, Zhao X1.(PubMed)
(2) Comparison of polyethylene glycol with and without electrolytes in the treatment of constipation in elderly institutionalized patients: a randomized, double-blind, parallel-group study by Seinelä L1, Sairanen U, Laine T, Kurl S, Pettersson T, Happonen P.(PubMed)
(3) Dietary intake in relation to self-reported constipation among Japanese women aged 18-20 years by Murakami K1, Okubo H, Sasaki S.(PubMed)
(4) History of Green Tea by Tao de Wan
(5) Constipation, Mayo Clinic
(6) Constipation and Obstructed Defecation by Scott R. Steele, M.D.1 and Anders Mellgren, M.D., Ph.D(PMC)
(7) Socioenvironmental factors associated with constipation in Hong Kong children and Rome III criteria by Tam YH1, Li AM, So HK, Shit KY, Pang KK, Wong YS, Tsui SY, Mou JW, Chan KW, Lee KH(PubMed)
( 8) Chronic constipation and treatment options (Review) by El-Salhy M1, Svensen R, Hatlebakk JG, Gilja OH, Hausken T(PubMed)

The Herb That Cure Type I Diabetes In Vivo and Vitro, Scientists Found

Kyle J. Norton

Scientist who work for the big pharmaceutical companies have tried mimicked and replace the effectiveness of herbal phytochemical single ingredient by their synthetic version, which can be patent for commercial profits.

Even they know exactly the discovery in treatment of certain diseases may induce serious side effect.

Therefore, if you are taking any conventional medicne, please discuss the adverse effects with your doctor.

Recent study suggested that Cat's Claw may be effective to cure of type 1 diabetes induced by Th1/Th2 (T cell) cytokine production.

Unlike type 2 diabetes which is caused by Insulin resistance due unhealthy diet, genetics,.... and lifestyle, type 1 diabetes is a chronic disease characterized by inability of the pancreas in produced insulin. a hormone with function in normalized the level of glucose caused by the immune system mistakenly attacks and destroys the beta cells in pancreas.

Researchers do not know why the immune system produces autoantibodies.to attack the pancreas beta cells? 

Patients with type 1 diabetes are associated to classical symptoms of frequent urination, increased thirst, increased hunger,..... and weight loss.

Some scientists in differentiation of the difference of type 1 and type 2 diabetes found that the symptoms of type 2 diabetes are developed over the a long period of time in compared to short period of time in type 1 patients.

According to the statistic in 2015, over 30 million Americans, or 9.4% of the population, had diabetes, including 125 million of children and adults who had developed type 1 diabetes.

Patient with type 1 diabetes must inject insulin for survival, however healthy diet and life style are also the must to improve quality of life and reduce risk of diabetic complications.

If Untreated or poor management, type 1 diabetes can cause long term complications of heart disease, stroke, kidney failure, foot ulcers,...... and eyes damage

Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..

The chemical constituents of Cat's claw include, ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.

In vivo, immunotoxicity testing, BALB/c male mice treated once a day with 125, 500 or 1250 mg/kg of U. tomentosa extract for 28 days, increased the number of T helper lymphocytes and B lymphocytes.

The whole herb medicine also significantly exerted a large stimulatory effect on lymphocyte(a form of small white blood cell) viability.

Other study involved C57BL/6 male mice injected with MLDS (40 mg/kg) orally treated with UT at 10-400mg/kg during 21 days, showed to express a significant protection against the loss of insulin-secreting presented β-cells, through modulated the production of two helper T cell classes, known as Th1 and Th2, with increased levels of type-2 T helper cells and mast cells, known as IL-5 and the protein regulated activities of white blood cells known as IL-2.

Further linking Interleukin-2 effected on type I diabetes, the study of Interleukin-2 and type 1 diabetes and several autoimmune diseases suggested that depended on interleukin-2 (IL-2) in proliferating and controlling the T effector cells (Teff) reaction, low dose IL-2 treatment at the initial time of diabetes can rescue insulin secretion by restoring proteins expression.

Dr. Rosenzwajg M, the lead author said, " Regulatory T cells (Tregs) play a major role in controlling effector T cells (Teffs) responding to self-antigens, which cause autoimmune diseases.,....and expanding/activating Tregs with low-dose interleukin-2 (IL-2) could provide immunoregulation without immunosuppression"

Cat's Claw may be effective in protein regulated activities of white blood cells, known as IL-2 through improvement of immune function in induced immunosuppression cause of Type I diabetes, but the quantity intake should only be prescribed by professional herbalist to prevent toxicity.

However, further data collection on studies performed with human consumption during the course of the disease will be necessary to complete the picture of its anti type 1 diabetes possibilities.

And intake of Cat's claw supplement and phytochemical should be taken with care, as acute liver toxicity caused by over doses had been reported in numbers of case.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization, regulatory T cell preservation or both? by Domingues A1, Sartori A, Golim MA, Valente LM, da Rosa LC, Ishikawa LL, Siani AC, Viero RM.(PubMed)
(2) Uncaria tomentosa aqueous-ethanol extract triggers an immunomodulation toward a Th2 cytokine profile by Domingues A1, Sartori A, Valente LM, Golim MA, Siani AC, Viero RM.(PubMed)
(3) Interleukin-2 and type 1 diabetes: new therapeutic perspectives by Hartemann A1, Bourron O.(PubMed)
(4) Interleukin 2 in the pathogenesis and therapy of type 1 diabetes by Rosenzwajg M1, Churlaud G, Hartemann A, Klatzmann D.(PubMed)

11 Fruits That Inhibit Prostate Cancer Cells, Scientist Suggested

Kyle J. Norton

In South East Asian, prostate cancer is considered a disease of aging male, now has become major concerns of governments and scientific community, because of its tendency to affect even younger age population.

Some researchers that the disease is the result of over consumption of bad fats accompanied with unhealthy diet and  life style, linking directly to the economic prosperity over 3 decades.

Some people who  have made a lot of money.in that region in past 3 decades are Western diet followers. Therefore, they are also susceptible to the diseases of Western world.

Dr. Salinas CA, the lead author at the joint studies led by the University of Michigan Medical School, said, "Prostate cancer is considered a disease of older men (aged >65 years), but today over 10% of new diagnoses in the USA occur in young men aged ≤55 years"(1).

Most of the younger age patients who have prostate cancer are diagnosed with low-risk of the disease. Although early diagnosis may increase chance of survival but these people may expose to long-term effects of treatment-related morbidities and risk of disease progression that can lead to death from prostate cancer(1).

Prostate cancer is a medical condition characterized by irregular cell growth in the prostate tissue. At the later state, the cancerous cells may travel a distance away from the original site to infect other healthy tissue or organ.

Besides inherited genes such as RNASEL and BRCA1 and BRCA2 that increase risk of prostate cancer, researchers do not know what causes prostate cancer. Howevover, there are numbers of risk factor which may increase risk of prostate cancer onset, including age, family history, obesity,...unhealthy diet.

Most prostate cancers are slow growing. Enlarged prostate and prostate cancer may be detected during physical (rectum) exams.

According to statistic in Canada, prostate cancer is a 3rd leading cause of death from cancer in men. in Canada.
In 2017(2)
 * 21,300 men were diagnosed with prostate cancer. This represents 21% of all new cancer cases in men in 2017.
 * 4,100 men died from prostate cancer. This represents 10% of all cancer deaths in men in 2017.
 * On average, 58 Canadian men were diagnosed with prostate cancer every day.
* On average, 11 Canadian men died from prostate cancer every day.

People in the early stage of prostate cancer may experience no symptoms. However, as the cancer progress, patient may encounter problems of urinating, blood in the urine or semen, trouble getting an erection (erectile dysfunction or ED), pain in the hips, back (spine), chest (ribs), or other areas from cancer that has spread to bones.... and numbness in the legs or feet(3)

In some serious cases, patient may also loss bladder or bowel control if the tumor is pressing on the spinal cord.

If you have suffered from some of the above symptoms, please check with your doctor right the way.

11 Fruits that Kills Prostate cancer Cells include
1. Mangosteen fruit
Mangosteen fruit, a tropical fruit growth in South East Asia is an evergreen tree originated in the Sunda Islands and the Moluccas of Indonesia.

In 22Rv1, LNCaP, and prostate epithelial cells (PrECs), standardized mangosteen fruit extract (MFE), suppressed tumor growth in a xenograft tumor model without causing damage to non-tumorigenic prostate epithelial cell through induction of toxicity(46).

Polyphenols, the main chemical constituent of the fruit extract also targeted multiple signaling pathways involved cell cycle arrest and apoptosis in prostate cancer(47).
rate
α-Mangostin, a xanthone derived from Polyphenols of mangosteen fruit, demonstrated a significant effect in exhibited cell cycle-related proteins involved in prostate carcinogenesis(48).

2. Long Pepper or Indian long pepper
Used as a spice and seasoning, Long Pepper or Indian long pepper is a flowering vine in the family Piperaceae.

Piperlongumine (PL), a natural alkaloid presented in the fruit inhibited prostate cancer through downregulation of Akt downstream signaling of cell proliferation, resulting in decrease mTORC1 (nutrient/energy)activity and autophagy (cell degradation)stimulation(49).

Application of PL also induced rapid depletion of the Androgen receptor (AR) in prostate cancer (PC) cells which is an early indication of prostate cancer(50).

In human prostate cancer DU145, PC-3 and LNCaP cells, piperine, another an alkaloid from black and longpeppers, also exhibited anti-proliferative effect in human prostate cancer cells by inducing cell cycle arrest and autophagy(51).

3. Pomegranate
Pomegranates is a fruit-bearing small tree, genus Punica, belongings to family Lythraceae, native to Iran, cultivated in Asian since ancient time.

POMx, a omegranate (PE) formula currently approved for clinical trials, effectively inhibited survivin (baculoviral inhibitor), induced apoptosis, retarded the rate of tumor growth in skeleton(52).

Polyphenols, main chemical compounds from pomegranate fruit extracts (PFEs), slightly decreased secretion of matrix metalloproteinase (MMP)-2 but not MMP-9 (expression usually seen in invasive and highly tumorigenic cancers) from prostate cancer cell lines(53).

Other polyphenol derivative, ellagic acid (EA) converted from Ellagitannins (ETs) from pomegranate juice (PJ), significantly decreased cell proliferation by exhibiting synergism in PC-3 cells(54).

4. Strawberry
Strawberries is a genius of Fragaria × ananassa belongings to the family Roseaceae, grown all over the world with suitable climate for commercial profits and for health benefits.

Application of berry juice study, including strawberry, inhibited prostate cancer cell proliferation, not involve caspase-dependent apoptosis, but in cell-cycle arrest, by down-regulation of the expression of cdk4, cdk6, cyclin D1 and cyclin D3(Decrease the proliferative activity (55).

In fact, major classes of berry phenolics, including anthocyanins, flavonols, flavanols, ellagitannins, gallotannins, proanthocyanidins, and phenolic acids are found to be effective in attenuated growth of many human cancer cell lines, including prostate (LNCaP) tumor cell lines at concentrations ranging from 25 to 200 micro g/mL.(56).

Crude extracts (250 microg/mL) from strawberry and its pure compounds (100 microg/mL) also induced apoptosis of prostate (LNCaP, DU145) cancer cells(57).

5. Grapes
Grape is a woody vines of the genus Vitis, belongings to the family Vitaceae, native to southern Turkey.

Fisetin, a chemical compound found in grape inhibited prostate cancer cell lines through downregulation of the PI3K/Akt (anti-apoptosis and increased cell proliferation)and the mTOR(energy sources) pathways(58).

Another chemical constituent pterostilbene, in dose-dependent ameliorated cellular proliferation, through activation of expression of AMPK(cellular energy homeostasis) and the p53(antigens).

But in p53 positive LNCaP cells, pterostilbene blocked the progression of cell cycle at G1 phase by inducing p53 expression and further up-regulating p21 expression and in p53 negative, induced apoptosis in PC3 cells(59).

Piceatannol found in grape, exhibited potential anticancer properties by suppressing proliferation of a wide variety of tumor cells, through cell-cycle arrest, upregulation of antibody antigens and apoptotic activity and down-regulation of cancer cell proliferation(60).

6. Apple
Apple is the pomaceous fruit of the apple tree, a species of the rose family Rosaceae, cultivated tree fruits. The tree is originated in Central Asia.

Apple peel extract (APE), exerted its anti cancer effects by significant decrease growth and enhanced clonogenic survival of human prostate carcinoma CWR22Rnu1 and DU145 cells, through a G0-G1(Cell cycle) phase arrest(61).

In the study of Does an apple a day keep the oncologist away? showed an inverse association of apple intake and incidence of cancer(62).

7. Papaya
Papaya is a species of Carica Papaya, belongings to the family Caricaceae and native to the tropics of the Americas, first cultivated in Mexico and several centuries.

Benzylisothiocyanate (BITC), a solvent of papaya fruit inhibited cancer cell line through induced apoptosis by converging two major pathways: the death receptor mediated extrinsic and the mitochondrial intrinsic pathway(63).

In the role of diet, papaya is effectively (more than 22.7 g/d (50th percentile) reduced prostate cancer risk by 7.4 (Adjusted OR 7.4 (95% CI 1.17-46.8)(64).

Lycopene, a major chemical constituent in tomato, also in papaya, in prospective and retrospective epidemiological studies showed an inverse relationship between lycopene intake and prostate cancer risk in vitro and in vivo(65).

8. Apricot
Apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belongings to the family Rosaceae.

Ethanolic extracts (30%) of apricot inhibited the growth of PC-3 and LNCaP (Prostate cancer cell lines) cells through induction of apoptosis via down regulating ERalpha (estrogen receptor α), ) and PKC-alpha(interaction with the cell membrane) protein, and binding of both mouse uterine estrogen receptors and LNCaP human androgen receptors(66).

9. Avocado
Avocado, a commercially valuable fruit cultivated in tropical climates throughout the world is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America.

Whole-blood fatty acids testing indicated that higher intakes of dietary MUFA(monounsaturated fatty) with principal source of dietary avocadointake was inversely related to prostate cancer(67).

Acetone extract of avocado, containing carotenoids and tocopherols decreased growth of both androgen-dependent (LNCaP) and androgen-independent (PC-3) prostate cancer cell lines in vitro.

Incubation of PC-3 cells with the avocado extract led to G(2)/M cell cycle arrest accompanied by an increase in p27(cell cycle inhibitor) protein expression(68).

10. Citrus fruits
The fruit is the genus Citrus, native to southern and southeast Asia, include grapefruit, lemon, orange, etc.

Study of incidence of prostate caner in North India compared to South India, showed a positive decreased risk of prostate cancer in increasing dietary consumption of tea, citrus fruits and melon(69).

Citrus consumption is associated with reduced all-cancer incidences, according to the study of cancer incidence among 42,470 Japanese adults in the Ohsaki National Health Insurance Cohort(70).

Oral administration of Gold Lotion (GL), an extract of multiple varieties of citrus peels containing abundant flavonoid, showed the deduction of both the weights (57%-100% inhibition) and volumes (78%-94% inhibition) of the tumors without inducing any adverse toxicity, accompanied by mechanistic down-regulation of the protein levels of inflammatory enzymes (inducible nitric oxide synthase, iNOS and cyclooxygenase-2, COX-2), metastasis (matrix metallopeptidase-2, MMP-2 and MMP-9), angiogenesis (vascular endothelial growth factor, VEGF), and proliferative molecules, as well as inducing apoptosis in prostate tumors(71).

Unfortunately, some studies did not show an association between intake of citrus fruits and risk of prostate cancer(72).

11. Bitter melon
Bitter melon, a extremely bitter fruit, is a tropical and subtropical vine belongings to the family Cucurbitaceae, native in Asia, Africa, and the Caribbean.

Treatment of bitter melon extract (BME) in prostate cancer, enhanced Bax expression(involved in p53-mediated apoptosis) and induced PARP(a nuclear protein implicated in DNA repair) cleavage(during apoptosis), delayed the progression to high-grade prostatic intraepithelial neoplasia (precede the development of prostate adenocarcinoma) and displayed approximately 51% reduction of proliferating cell nuclear antigen expression in mice(73).

MCP30, from bitter melon seeds induced apoptosis in PIN and PCa cell lines in vitro and suppressed PC-3 growth in vivo with no effect on normal prostate cells(74).

Bitter melon leaf extract (BMLE) inhibited the secretion of MMP-2, MMP-9(metastasis) and urokinase plasminogen activator (uPA)(invasion and metastasis) from rat prostate cancer cell line (PLS10)(75).

Taken altogether, the  findings suggested that certain fruits and theirs bioactive compound may have a strong impact in reduced risk, progression and treatment of prostate cancer. However, due to limitation of the sample, a large cohost study with larger sample size are necessary to reconfirm their viability.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrion, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
(1) Prostate cancer in young men: an important clinical entity by Salinas CA1, Tsodikov A2, Ishak-Howard M1, Cooney KA(PubMed)
(2) Prostate cancer statistics(Canadian Cancer Society)
(3) Signs and Symptoms of Prostate Cancer(US Cancer Society)
(46) Selective modulation of endoplasmic reticulum stress markers in prostate cancer cells by a standardized mangosteen fruit extract by Li G1, Petiwala SM1, Pierce DR1, Nonn L2, Johnson J(PubMed)
(47) Polyphenols from the mangosteen (Garcinia mangostana) fruit for breast and prostate cancer by Li G, Thomas S, Johnson JJ.(PubMed)
(48) α-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth by Johnson JJ, Petiwala SM, Syed DN, Rasmussen JT, Adhami VM, Siddiqui IA, Kohl AM, Mukhtar H.(PubMed)
(49) Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death by Makhov P, Golovine K, Teper E, Kutikov A, Mehrazin R, Corcoran A, Tulin A, Uzzo RG, Kolenko VM.(PubMed)
(50) Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells by Golovine KV, Makhov PB, Teper E, Kutikov A, Canter D, Uzzo RG, Kolenko VM.(PubMed)
(51) Piperine inhibits the proliferation of human prostate cancer cells via induction of cell cycle arrest and autophagy by Ouyang DY, Zeng LH, Pan H, Xu LH, Wang Y, Liu KP, He XH.(PubMed)
(52) Pomegranate extract inhibits the bone metastatic growth of human prostate cancer cells and enhances the in vivo efficacy of docetaxel chemotherapy by Wang Y, Zhang S, Iqbal S, Chen Z, Wang X, Wang YA, Liu D, Bai K, Ritenour C, Kucuk O, Wu D.(PubMed)
(53) Ellagic acid inhibits migration and invasion by prostate cancer cell lines by Pitchakarn P, Chewonarin T, Ogawa K, Suzuki S, Asamoto M, Takahashi S, Shirai T, Limtrakul P.(PubMed)
(54) Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and Apoptosis by Vicinanza R, Zhang Y, Henning SM, Heber D.(PubMed)
(55) Inhibition of cancer cell proliferation and suppression of TNF-induced activation of NFkappaB by edible berry juice by in D, Blanchette M, Barrette S, Moghrabi A, Béliveau R.(PubMed)
(56)Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)
(57)Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative properties by Zhang Y, Seeram NP, Lee R, Feng L, Heber D.(PubMed)
(58) Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management by Adhami VM, Syed DN, Khan N, Mukhtar H.(PubMed)
(59) Activation of AMPK by pterostilbene suppresses lipogenesis and cell-cycle progression in p53 positive and negative human prostate cancercells by Lin VC, Tsai YC, Lin JN, Fan LL, Pan MH, Ho CT, Wu JY, Way TD.(PubMed)
(60) Biological activity of piceatannol: leaving the shadow of resveratrol by Piotrowska H, Kucinska M, Murias M.(PubMed)
(61) Antiproliferative effects of apple peel extract against cancer cells by Reagan-Shaw S, Eggert D, Mukhtar H, Ahmad N.(PubMed)
(62) Does an apple a day keep the oncologist away by Gallus S, Talamini R, Giacosa A, Montella M, Ramazzotti V, Franceschi S, Negri E, La Vecchia C.(PubMed)
(63) Dietary isothiocyanate mediated apoptosis of human cancer cells is associated with Bcl-xL phosphorylation by Basu A, Haldar S.(PubMed)
(64) Roles of diet, lifetime physical activity and oxidative DNA damage in the occurrence of prostate cancer among men in Klang Valley, Malaysia by Shahar S, Shafurah S, Hasan Shaari NS, Rajikan R, Rajab NF, Golkhalkhali B, Zainuddin ZM.(PubMed)
(65) Multitargeted therapy of cancer by lycopene by van Breemen RB, Pajkovic N.(PubMed)
(66) Phytosterol Pygeum africanum regulates prostate cancer in vitro and in vivo by Shenouda NS, Sakla MS, Newton LG, Besch-Williford C, Greenberg NM, MacDonald RS, Lubahn DB.(PubMed)
(67)Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica by Jackson MD, Walker SP, Simpson-Smith CM, Lindsay CM, Smith G, McFarlane-Anderson N, Bennett FI, Coard KC, Aiken WD, Tulloch T, Paul TJ, Wan RL.(PubMed)
(68)Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances by Lu QY, Arteaga JR, Zhang Q, Huerta S, Go VL, Heber D(PubMed)
(69) A case control study on prostate cancer in Delhi by Tyagi B, Manoharan N, Raina V.(PubMed)
(70) Citrus consumption and cancer incidence: the Ohsaki cohort study by Li WQ, Kuriyama S, Li Q, Nagai M, Hozawa A, Nishino Y, Tsuji I.(PubMed)
(71) Potent anti-cancer effects of citrus peel flavonoids in human prostatexenograft tumors by Lai CS, Li S, Miyauchi Y, Suzawa M, Ho CT, Pan MH.(PubMed)
(72) Citrus fruits intake and prostate cancer risk: a quantitative systematic review by Bae JM, Lee EJ, Guyatt G.(PubMed)
(73) Bitter melon extract impairs prostate cancer cell-cycle progression and delays prostatic intraepithelial neoplasia in TRAMP model by Ru P, Steele R, Nerurkar PV, Phillips N, Ray RB.(PubMed)
(74) Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in premalignant and malignant prostate cancer cells by Xiong SD, Yu K, Liu XH, Yin LH, Kirschenbaum A, Yao S, Narla G, DiFeo A, Wu JB, Yuan Y, Ho SM, Lam YW, Levine AC.(PubMed)
(75) Momordica charantia leaf extract suppresses rat prostate cancerprogression in vitro and in vivo by Pitchakarn P, Ogawa K, Suzuki S, Takahashi S, Asamoto M, Chewonarin T, Limtrakul P, Shirai T.(PubMed)