A Herbal Gel That Is Better Than Non-Steroidal Anti-Inflammatory Medications in Healing Ecchymosis With No Side Effects

Arnica may have a potential and therapeutic effect in reduced expression of Ecchymosis, through its anti inflammatory activities, some scientists suggested.

The results of these efficacy were confirmed by some studies conducted by numbers of respectable institutes, including University of Miami Miller School of Medicine and University of South Florida.

Ecchymosis is a condition of discoloration of the skin as a result of bleeding underneath. In most cases it is caused by bruising.

Some people may be mistaken a hematoma as ecchyymosis.

Normally, ecchyymosis is any bruising less than 1 cm and ecchymosis is considered as a hematoma if the bruising of skin is larger than 1 cm.

In other word, hematoma contains blood clots which can be felt when touched, and often exerting symptoms of pain and tenderness, in compared to ecchymosis.

The most common symptoms of ecchymosis is the progression of colors, usually follow this order: red or purple, black or blue, brown and yellow.

Truly, ecchymosis mostly appears on your arms and legs since they’re most likely to be injured. However, bruising can also happen to anywhere such as strain or sprain a bone, particularly in wrist or ankle.

Long term intake of certain medication such as blood thinners, such as aspirin or warfarin, antibiotics,.... and corticosteroids also increases risk of bleeding and bruising.

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, antive to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is process of repairing after damage of skin, tissues, organs, etc.


The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative.


In order to confirm the effect of herbal Arnice activity in treatment of ecchymosis in patients who under went rhinoplasty, the most common facial plastic surgical procedure, researchers at the joint study lead by the University of South Florida independently conducted a review of literature in databases (PubMed, SCOPUS, Embase, Web of Science, and the Cochrane database) from inception to September 2016, included studies that compared postoperative care methods (intervention groups) with no treatment (control group).

According to the final searching of 11 trials satisfied the criteria and guideline with a total of 627 patients, application of topical Arnica showed a significant effect in reduced eyelid ecchymosis during the first 7 days postoperative statistically in compared to the control group.

However, eyelid ecchymosis during the first 24 h postoperatively were statistically decreased in the cold compression group in compared to the control group.

Patients' questionnaires returned also expressed a strong satisfaction in the tapping application group than in the control group.

Also, the ratio of patient satisfaction was statistically higher in the tapping and Arnica application group than in the control group.

Additionally, the analysis also found that surgeons had a significant tendency to decrease intranasal packing in remove pain from the surgery area as the placement was found to associate with more adverse effects in terms of postoperative ecchymosis compared to non-packing.

Further differentiation to confirm the effectiveness of the combination of topical Arnica montana and Rhododendron tomentosum (Ledum palustre) in reducing postoperative ecchymosis in a select population of healthy volunteers after oculofacial surgery, researchers conducted a review examined the postoperative course of healthy volunteers using topical Arnica and Ledum after undergoing common oculofacial procedures, including blepharoplasty, browpexy, and rhinoplasty, in the hands of 4 surgeons at tertiary referral centers from July 1, 2012 to December 31, 2012 using medical records review.

A total of 27 patients (16 females, 11 males) with age range of 18 to 70 years were included in the study.

Selected medical review showed that patients included had used topical hydrogel pads (OcuMend, Cearna Inc., Chicago, IL) containing Arnica 50 M (10) 50% and Ledum 50 M (10) applied bilaterally after surgery through postoperative day 6 at each postoperative visit.

The results of everyday progression in patients were evaluated by their respective surgeons and assigned a subjective physician-patient rating score comparing each patient's observed healing compared with expected healing if not using Arnica/Ledum.

Photographs in each examination also were recorded.The median duration of follow-up was 7 days, range from 1 to 14 days.

According to the rating of physician examined the results, the proportions of patients with markedly accelerated healing were 38.5% (5 of 13), 85.7% (6 of 7), 60.0% (12 of 20), and 51.9% (14 of 27) at POD 1 to 2, 3 to 5, 6 to 8, and overall, respectively.

The proportions of patients with accelerated healing at the same time points were 15.4% (2 of 13), 14.3% (1 of 7), 30.0% (6 of 20), and 37.0% (10 of 27), respectively.


The proportion of patients using Arnica/Ledum with markedly accelerated healing was significantly more than the proportion of those demonstrating no appreciable difference from expected at (post operative day) POD 3 to 5 (85.7% vs. 0%, p = 0.05), POD 6 to 8 (60.0% vs. 10.0%), and overall (51.9% vs. 11.1%, p = 0.05) without inducing any adverse effects.


Dr. Lee HS, the lead author said, "The preliminary results from this study demonstrate that the combination of topical Arnica montana and Rhododendron tomentosum (Ledum palustre) may be effective in reducing postoperative ecchymosis....,after oculofacial surgery".


Taken together, topical Arnica may be considered as a functional food to accelerated the healing of ecchymosis

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Assessing the Effectiveness of Arnica montana and Rhododendron tomentosum (Ledum palustre) in the Reduction of Ecchymosis and Edema After Oculofacial Surgery: Preliminary Results by Kang JY1, Tran KD, Seiff SR, Mack WP, Lee WW.(PubMed)
(2) The effectiveness of postoperative intervention in patients after rhinoplasty: a meta-analysis by Lee HS1, Yoon HY1, Kim IH1, Hwang SH2.(PubMed)
(3) Is There a Role for Arnica and Bromelain in Prevention of Post-Procedure Ecchymosis or Edema? A Systematic Review of the Literature by Ho D1, Jagdeo J, Waldorf HA.(PubMed)

A Simple Drink That Exerts Maximum Protection of Your Bone

Kyle J. Norton

"Let foods be your medicine and let medicines be your food", using foods as medication has been a dream of many scholars and scientists over past many centuries.

In order to achieve these, consumption of whole food medicine must accompany with moderated exercise, change of diet and life style.

Evidence from laboratory studies opinionated, regular drinking of green tea improved bone health and reduced risk of osteoporosis and fractures.

Bone health is measured by bone mineral density which has an direct influence in risk of osteoporosis and fractures.

There are numbers of bone diseases, including include osteoporosis, rickets, osteomalacia, osteogenesis imperfecta, marble bone disease (osteopetrosis), Paget disease of bone, and fibrous dysplasia.

And osteoporosis is most frequently occurrence in aging population.

Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time. 

It is a widespread degenerative disease of skeletal joints and often associated with senescence in vertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries.

If you experience symptoms of lower back pain, loss of height over time, a stooped posture, easy bone fracture, neck and back pain,... , you may have osteoporosis. 

Truly, bone diseases affect normal growth and development that can lead to weakness and/or deformity. 

The causes of bone diseases may be associated to genetic abnormalities, nutritional deficiencies, hormonal disorders, infections, cancers..... and other conditions.

According to the general belief and the recommendation of health researchers, good diet and physical exercise may play an important role of skeletal mass at the end of adolescence and these bone mass are remained as the conservation of it during adult life(1).

Attending normal exercise and intake of bone enhancing food at young adult life may protect ourself against risk of bone diseases as we age.

However, the study did mention the effect of diet and exercise in influence of hone health in muscular diseases as in many cases, they are correlated.

In compared to physical inactivity and non weight bearing activities, weight bearing activities in adulthood., such as walking, running. have a greater effect in improved bond mass. However, Intense training may cause damage, promptly repaired, as in stress fractures observed in many instances.

Dr. Branca F, at the National Institute of Nutrition in Rome said, "Calcium intake should also be analysed in the light of other dietary factors affecting the balance between absorption and excretion, and in combination with a number of other minerals, trace elements and bioactive substances with an impact on bone metabolism".

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

However, as yin in nature herbal medicine ,or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. But adding a slice of ginger will benign the problem.

According to Texas Tech University Health Sciences Center, green tea lovers have a reduced risk of lower bone mineral density due to its bioactive components with bone-protective properties.

The study also found that, regular green tea drinking promotes bone health in bone mineral loss menopausal women through increased bone mass, thus reducing risk of osteoporosis, a common disease in aging population.

Furthermore, intake of green tea also protected early onset of bone mineral loss in obese subjects.

Other study conducted by the same group of researchers also stated, the bone density protective effect of green tea may involve the bioactive components' effects in decreased risk of fracture by supporting osteoblastic activities while suppressing osteoclastic activities as well as attenuating oxidative stress in promoted healthy levels of bone mineral density.

In postmenopausal osteopenic women study, green tea with optimized dose of polyphenols showed an enhanced osteoprotective efficacy in improved bone mass, microarchitecture integrity, and bone strength observed through the advanced imaging technology.


Dr, Shen CL, the lead author in the studies said, " Tea polyphenols enhance osteoblastogenesis and suppress osteoclastogenesis in vitro" and "Animal studies reveal that intake of tea polyphenols have pronounced positive effects on bone as shown by higher bonemass and trabecular bone volume, number, and thickness and lower trabecular separation via increasing boneformation and inhibition of bone resorption, resulting in greater bone strength".

Promisingly, in a total study of 171 postmenopausal osteopenic women to compare the efficacy of green tea polyphenols (GTP) supplement and/or Tai Chi in risk of osteoporosis, randomly assigned to four groups: (1) placebo (500 mg starch/day), (2) GTP (500 mg GTP/day), (3) placebo + TC (placebo plus TC training at 60 min/session, three sessions/week), and (4) GTP + TC (GTP plus TC training).for 6 months, intake of green and tai chi exercise groups increased bone-specific alkaline phosphatase(bone protective glycoprotein found on the surface of osteoblasts) and improved BAP/(tartrate-resistant acid phosphatase, osteoclast increased risk of bone turnover)/TRAP ratio.

Additionally, group received also green tea showed a significant improved muscle strength in postmenopausal women with osteopenia.

Taking together, green tea may be served as functional food to protect bone health, particularly, the bone mineral density in all people with/ without risk of osteoporosis.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

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Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Physical activity, diet and skeletal health by Branca F(PubMed)
(2) Green tea and bone health: Evidence from laboratory studies by Shen CL1, Yeh JK, Cao JJ, Chyu MC, Wang JS.(PubMed)
(3) Green tea and bone metabolism by Shen CL1, Yeh JK, Cao JJ, Wang JS.(PubMed)
(4) Tea and bone health: steps forward in translational nutrition by Shen CL1, Chyu MC, Wang JS.(PubMed)
(5) Effect of green tea and Tai Chi on bone health in postmenopausal osteopenic women: a 6-month randomized placebo-controlled trial by Shen CL1, Chyu MC, Yeh JK, Zhang Y, Pence BC, Felton CK, Brismée JM, Arjmandi BH, Doctolero S, Wang JS.(PubMed)
(6) Bone disease in post-transplant patients by Jeon HJ1, Kim H, Yang J.(PubMed)

Infectious Diseases: The Phytochemicals That Suppress Over Growth of Candida, Scientists Say

By Kyle J. Norton, Scholar, Master of Nutrition

Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.

Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).

Phytochemicals are various biologically active compounds found in plants.

The major function of these chemical compound is to protect the host plant against oxidation

Today, the name list of phytochemicals found in plants are only represented a tiny fraction of entire pytochemicals family.

According to general belief, human will never find a complete list of phytochemicals in plants which contains millions of known and unknown species.

In human, intake of phytochemical regularly from food sources is found to exhibit certain health benefits, including

* To act as antioxidant against free radical over expression in initiated change of cellular DNA - the early onset of developing certain types of cancer(a)

* To act as hormones modulator against imbalance of hormone in the host(b).

* To act as enzymes stimulator against imbalance of ratio of host antioxidant and ROS levels(c).

High levels of free radical facilitated oxidative stress are associated to risk of chronic physical and mental health.

Imbalance of ratio of ROS species and antioxidant enzymes in the host tissue have played an essential role in initiated expression of healthy cell cytotoxicity that can alternate DNA transcription in precipitated the development of of chronic ailments such as over growth of candida.

* To act as anti infection agent(d) against micro organisms which cause inflammation due acute and chronic infection.

In many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and over expression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.

The Anti Over Growth of Candida Phytochemicals

1. L-glutamine
L-glutamine is one of the 20 amino acids encoded by the standard genetic code and used to treat certain gastrointestinal disorders(342)(343) by serving as a source of fuel for the cells that line the gastrointestinal tract.

According to Ankara University, L-glutamine inhibited the over growth of candida through its antimutagenic and antimicrobial activities(344).

2. N-acetyl-glucosamine
N-acetyl-glucosamine is a monosaccharide derivative of glucose that supports the digestive track function and maintains healthy intestinal lining by stimulating cell growth in the intestinal track(345).

According to National Institute of Plant Genome Research, GIG2 (GlcNAc-induced gene 2). involved in the metabolism of N-acetylneuraminate (sialic acid), effectively decreased fungal burden in mouse model(346).

3. Rice-bran oil Extracted
 from the germ and inner husk of rice, containing a compound gamma-oryzanol(347) showed to reduce the risk of gastric ulcers caused by stress while at the same time maintaining gastrointestinal motility(348).

According to Manipal Academy of Higher Education (Deemed University, rice bran oil immobilized lipase from Candida, a potential pathway for fungal overgrowth(349).

4. Pancreatic enzymes supplements
Pancreatic enzymes, found as supplements and in certain foods allow more bacteria to grow in the intestine by enabling the food to be digested a lot easier(350). Insufficient pancreatic enzymes can quickly encourage Candida overgrowth in the digestive tracts(351).

5. Butyric acid
Butyric acid, a fatty acid occurring in the form of esters in animal fats and plant oils, was effective in inhibited pathogenic organisms(352) through improved digestion and promoted intestinal health(353) by producing bacteria to feed on lactic acid, then multiplying and revving up their production(354) .

Butyric acid also consists anti-inflammatory property(355) and strengthens the intestinal mucosal barrier.(356).

5. Fructo-oligosaccharides(FOS)
Fructo-oligosaccharides(FOS) is a class of oligosaccharides used as an artificial or alternative sweetener(357), extracted from fruits and vegetables such as bananas, onions, chicory root, garlic, asparagus, barley, wheat, tomatoes, and leeks(358). It is inulin-type prebiotics(359), stimulated the growth of friendly bacteria in the intestine track to counter react to other bad bacteria(360)(362) such as candida. Oligosaccharides also induce gas formation, through increasing faecal biomass and water content of the stools, for improvement of bowel habits(361),

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Sources
(a) Effective anti-cancer property of Pouteria sapota leaf on breast cancer cell lines by Prabhu DS1, Selvam AP2, Rajeswari VD(PubMed)
(b) Phytosteroids beyond estrogens: Regulators of reproductive and endocrine function in natural products by Dean M1, Murphy BT1, Burdette JE(PubMed)
(c) Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress by Reuland DJ1, Khademi S, Castle CJ, Irwin DC, McCord JM, Miller BF, Hamilton K(PubMed)
(d) Antibacterial activities, phytochemical analysis and chemical composition Makhlaseh extracts against the growth of some pathogenic strain causing poisoning and infection by Alizadeh Behbahani B1, Imani Fooladi AA(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(342) Glutamine supplementation for young infants with severe gastrointestinal disease. by Brown
JV1, Moe-Byrne T, McGuire W.(PubMed)
(343) Glutamine and intestinal barrier function ,By Wang B1, Wu G, Zhou Z, Dai Z, Sun Y, Ji Y, Li W, Wang W, Liu C, Han F, Wu Z.(PubMed)
(344) Schiff bases attached L-glutamine and L-asparagine: first investigation on antimutagenic and antimicrobial analyses by Sakiyan I1, Anar M, Oğütcü H, Agar G, Sarı N.(PubMed)
(345)Explore The Truth On Cures For Yeast Infection(Thing for Ladies)
(346) and maintains healthy intestinal lining(Thing for Ladies)(347) Role of gamma-oryzanol in drought-tolerant and susceptible cultivars of rice (Oryza sativa L.) by Kumar MS, Dahuja A, Rai RD, Walia S, Tyagi A.(PubMed)
(348) [Effects of gamma-oryzanol on gastric lesions and small intestinal propulsive activity in mice].
[Article in Japanese] by Ichimaru Y, Moriyama M, Ichimaru M, Gomita Y.(PubMed)(349) Hydrolysis of rice bran oil using an immobilized lipase from Candidarugosa in isooctane by Murty VR1, Bhat J, Muniswaran PK.(PubMed)
(350) The use of dual-isotope imaging to compare the gastrointestinaltransit of food and pancreatic enzyme pellets in cystic fibrosis patients by Hillel PG1, Tindale WB, Taylor CJ, Frier M, Senior S, Ghosal S.(PubMed)
(351) The Best Digestive Enzymes For Candida(Digestive health Guide)
(352) Purification and characterization of antibacterial substances produced by a marine bacterium Pseudoalteromonas haloplanktis strain by Hayashida-Soiza G1, Uchida A, Mori N, Kuwahara Y, Ishida Y.(PubMed)
(353) Induction of rhythmic transient depolarizations associated with waxing and waning of slow wave activity in intestinal smooth muscle by Pawelka AJ1, Huizinga JD2.(PubMed)
(354) Fermentation Analysis & Evaluation(daily one)
(355) Anti-inflammatory effects of sodium butyrate on human monocytes: potent inhibition of IL-12 and up-regulation of IL-10 production by Säemann MD1, Böhmig GA, Osterreicher CH, Burtscher H, Parolini O, Diakos C, Stöckl J, Hörl WH, Zlabinger GJ.(PubMed)
(356) Inhibition of p38 mitogen-activated protein kinase attenuates butyrate-induced intestinal barrier impairment in a Caco-2 cell monolayer model by Huang XZ1, Li ZR, Zhu LB, Huang HY, Hou LL, Lin J.(PubMed)
(357) Functional characterization of sucrose phosphorylase and scrR, a regulator of sucrose metabolism in Lactobacillus reuteri by Teixeira JS1, Abdi R, Su MS, Schwab C, Gänzle MG.(PubMed)
(358) Fructo-oligosaccharides(FOS)(Wikipedia)
(359) [Synthesis of novel fructo-oligosaccharides (FOS) by enzymatic reaction].[Article in French]by Grizard D1, Barthomeuf C.(PubMed)
(360) Inulin-type prebiotics--a review: part 1 by Kelly G.(PubMed)
(361) Introducing inulin-type fructans by Roberfroid MB1.(PubMed)
(362) Studies with Inulin-Type Fructans on Intestinal Infections, Permeability, and Inflammation,
by Francisco Guarner(The Journal of Nutrition)

Common Types of Free Radicals That Cause Oxidation and Cytotoxicity, You May Not Know

By Kyle J. Norton

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. As oxidants or reductants, they can donate or accept an electron from other molecules to exhibit chain and domino's effects.

They may have positive, negative or zero charges. 

The unpaired electrons cause radicals to be highly chemically reactive in the human body, leading to aging and cancers.

However, injection of free radicals into cancer cells may induce cells death and inhibit tumor proliferation.

These results suggested that free radicals have a duo function in mediated cellular processes. On one hand, they cause alternation of DNA of healthy cells into cancerous cells. On the other hand, free radical can cause apoptosis of cancer cells through cytotoxicity(1).

Some researchers went even further to suggest that free radical such as H2O2 signaling pathway plays an essential role in the creation of a bridge between insulin receptor and mitochondrial function in neurons(1)

And, overexpression of antioxidant caused by intake of supplementation can also be dangerous to signaling role in cells(2) and increase risk motility(3). For example, integral mitochondrial Manganese superoxide dismutase µMnSOD) protein possesses peroxidase activity when the enzyme is overexpressed in mitochondria(2).

Most common Types of Free radical include
1. Hydroxyl radical (OH•)
The hydroxyl radical is the neutral form of the hydroxide ion (OH–). It is produced from the decomposition of hydroperoxides (ROOH) by the reaction of an elevation in energy level above an arbitrary baseline energy state molecular oxygen with water.
The hydroxyl radical is highly reactive and has a very short in vivo half-life of approx. 10−9 s This makes it a very dangerous compound to the organism. Hydroxyl radical cannot be eliminated by an enzymatic reaction and can damage virtually all types of macromolecules: carbohydrates, nucleic acids (mutations), lipids (lipid peroxidation) and amino acids, that makes it a very dangerous compound to shorten the lifespan of a human being.

2. Superoxide anion radical (O2–•)
A superoxide anion is a compound that possesses an atom or molecule in which the total number of electrons is not equal to the total number of protons, giving it a net positive or negative electrical charge with the chemical formula O2− with one unpaired electron, leading to the generating of superoxide anion free radical.
Mutations in the gene coding for the NADPH oxidase cause immune deficiency chronic granulomatous disease, leading to extreme susceptibility to infection and pathogenesis of many diseases, including aging.


3. Singlet oxygen
Singlet oxygen is the common name used for the diamagnetic form of molecular oxygen (O2), which is less stable than the normal triplet oxygen. In the biological study, species, Singlet oxygen causes oxidation of LDL-cholesterol and resultant cardiovascular effects.

Since singlet oxygen with activation by light can produce severe photosensitivity of skin, leading to skin defects.

4. Hydrogen peroxide
Hydrogen peroxide (H2O2) is the simplest peroxide, a clear liquid, slightly more viscous than water, that appears colorless in dilute solution. 

It is considered a highly reactive oxygen species because of its strong oxidizing capacity.

A study published in Nature found that hydrogen peroxide plays a role in the immune system by signaling the white blood cells to converge on the site of damage. The process leads to white blood cells did not accumulate at the site of damage, but somewhere else if the gene in the production of hydrogen peroxide is altered, causing higher levels of hydrogen peroxide and white blood cells in their lungs accumulation in the lung than healthy people.

5. Lipid peroxyl free radical
Lipid peroxidation is a process in which free radicals steal electrons from the lipids in cell membranes, most often affecting polyunsaturated fatty acids, resulting in damaging to the cell membrane, which consists mainly of lipids, because of chain reaction after initial oxidating by producing even more lipid peroxyl free radicals if not bought under controlled fast enough.

6. Nitric oxide
Nitric oxide is a chemical compound with chemical formula NO. Even though low levels of NO production are important in protecting the liver from ischemic damage and contribute to proper smooth muscle contraction and growth, but its free radical and toxic nature can cause DNA damage and inflammation.

7. Alkoxyl radical
Alkoxyl radical which is an alkyl (carbon and hydrogen chain) group singular bonded to oxygen can result in cellular damage caused by oxyfluorfen, a herbicide.

8. Peroxynitrite
Peroxynitrite is the anion with the formula ONOO−reacted quickly with carbon dioxide, leading to forming of carbonate and nitrogen dioxide radicals.

If the two radicals do not recombine to form carbon dioxide and nitrate, they can cause peroxynitrite-related cellular damage.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca



Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Recognition of Functional Roles of Free Radicals by István Bókkon(PMC)

(2) The peroxidase activity of mitochondrial superoxide dismutase. Free Radic Biol. by Ansenberger-Fricano K, Silva Ganini DD, Mao M, Chatterjee S, Dallas S, Mason RP, Stadler K, Santos JH, Bonini MG(PubMed)

(3)  The neglected significance of "antioxidative stress".by Poljsak B, Milisav I (PubMed)

The Veggies That Inhibit Advanced Glycation End Products in Induction of Diabetic Vascular Complications

Kyle J. Norton, Scholar, Master of Nutrition


Conventional medicine has tried for years to synthesize the effect of many herbal plants' for treatment of diseases, since the discovered of penicillin the first antibiotic extracted from a very primitive plant, the fungus Penicillium, in 1928, used for treatment of infection.

However, the findings has drawn many criticism, as single ingredient isolated from herb through synthetic version for patent right and commercial profit has induced someserious side effect.

Some researchers suggested that by using single ingredient to treat one ailment, conventional medicine may exhibit several side effect and conditions if such medicine are taken in the long term.

According to traditional Chinese medicine, the single and synthetic version of conventional medicine are so powerful, long term intake may cause damage to the kidney such as antibiotics, diuretics,....
 and liver, such as statins, antibiotics......

According to Fred Hutchinson Cancer Research Center, long-term use of some high blood pressure drugs associated with increased risk of breast cancer in postmenopausal women(8).

But many researchers have raised question of herbal quality, because geographic differences, time of grown and harvest, etc. may effect their's potency.

 Cruciferous vegetables consumption regularly may be beneficiary in reduced risk of diabetic vascular complications, some scientists suggested.

Cruciferous vegetables are the group of vegetables belongings to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy,.... and broccoli.

Diabetic vascular complications are caused by diverse group of highly oxidant compounds(advanced glycation end(AGEs) produced by modern heat-processed diet, inducing pathogenic significance in diabetes and several other chronic diseases.

Patients with diabetes are associated to intense levels of advanced glycation end products. The toxic substance accumulated over time may have significantly damage effect in  host organs and tissue, as aging progress.

In some cases, the toxins can cause death to the host.

Some researchers suggested that accumulated advanced glycation end products also consisted a strong implication in escalated aging process.

According to the Dr. JAIME URIBARRI, MD and colleagues at the Mount Sinai School of Medicine, "The formation of new dAGEs during cooking was prevented by the AGE inhibitory compound aminoguanidine and significantly reduced by cooking with moist heat, using shorter cooking times, cooking at lower temperatures, and by use of acidic ingredients such as lemon juice or vinegar".

Due to its complex association to oxidative stress in aging population, advanced glycation end-products (AGEs) have also strong implication  in induction of many neurodegenerative diseases, including Huntington disease, amyotrophic lateral sclerosis, and Alzheimer disease.

Diabetes is a condition caused by insufficient insulin entering the bloodstream in regulation of  glucose.

The disease is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol.

Long term uncontrolled diabetes may cause complications that can lead to renal failure and cardiovascular events.


Dr, Yamagishi S, the lead author said, " the Inhibition of AGE formation, blockade of the AGE-RAGE interaction, and suppression of RAGE expression or its downstream pathways may be novel therapeutic strategies for the treatment of vascular complications in diabetes"

Advanced glycation end-products (AGEs) interaction with RAGE stimulate the generation of reactive oxygen species (ROS) mainly through the activity of NADPH oxidases, a membrane-bound enzyme with function in induction of ROS expression.

Some researchers insisted that diabetic vascular complications may be blocked if food-advanced glycation end products aggravated diabetic vascular complications can be modulated via the RAGE receptors in removal of AGE.

According to the Kurume University School of Medicine, sulphoraphane, a phytochemical compound found in cruciferous vegetables showed a potential effect against diabetic vascular complications, through its interference of pro inflammatory reaction, reduction of oxidate stress.

In other words, application of sulforaphane exerted an inhibition of RAGE function in decreased DNA synthesis, apoptotic cell death in the host by increased monocyte chemoattractant protein 1 messenger RNA levels in protection against pro inflammatory exertion in pericytes, the endothelial cells that line the capillaries and venules.

These efficacy was found in  cultured cells and experimental animals.

In vivo and vitro, sulforaphane suppressed inflammatory activation of vascular cells, induced potential beneficial effects to prevent vascular inflammation and atherosclerosis complication of diabetics.

Also. intake of cruciferous vegetables may reduce risk of diabetic vascular complication as sulphoraphane, a phytochemical compound in cruciferous vegetables not only inhibited the levels of advanced glycation end but also enhanced the production of Nrf2 in controlling of over 500 genes expression of cellular defense mechanisms.

The nuclear factor E2-related factor 2 (Nrf2) is a transcription factor with function that activates the natural antioxidant enzymes found in the host tissue in response to oxidative stress.

Oxidative stress is an indication imbalance of the ratio of the levels of antioxidants and free radical in the host body.

Therefore, in prevention of diabetic vascular complications, people with diabetes may want to add a portion of cruciferous vegetables into their daily diet.

Intake of sulforaphane supplement should be taken with extreme care, as acute liver toxicity may be induced if overdose.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton, Scholar, Scholar, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Protective role of sulphoraphane against vascular complications in diabetes by Yamagishi S1, Matsui T1.(PubMed)
(2) Agents that block advanced glycation end product (AGE)-RAGE (receptor for AGEs)-oxidative stress system: a novel therapeutic strategy for diabetic vascular complications by Yamagishi S1, Nakamura K, Matsui T, Ueda S, Fukami K, Okuda S.(PubMed)
(3) The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease by Paul C. Evans(PMC)
(4) Food-advanced glycation end products aggravate the diabetic vascular complications via modulating the AGEs/RAGE pathway by Lv X1, Lv GH1, Dai GY1, Sun HM2, Xu HQ3.(PubMed)
(5) Advanced glycation end product Key players in skin aging? by Paraskevi Gkogkolou and Markus Böhm(PMC)
(6) Advanced glycation end products in foods and a practical guide to their reductionin the diet by Uribarri J1, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R, Yong A, Striker GE, Vlassara H.(PubMed)
(7) Neuronal cell death and regeneration in diseases associated with advanced glycation end-products accumulation by Bikbova G1, Oshitari T1, Yamamoto S(PubMed)
(8) Long-term use of some high blood pressure drugs associated with increased risk of breast cancer in postmenopausal women by Fred Hutchinson Cancer Research Center

A Common and Kitchen Spice that Curbs Diabetes Naturally

Kyle J. Norton


Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

Type 1 diabetes is a congenital condition caused by die off of pancreas cells which are responsible for production insulin, a hormone with function to control the level of blood glucose.

Regular injection of insulin or insulin therapy is required daily in patient who was born with the disease.

In contrast to type II diabetes, types 1 diabetes are not associated to dietary intake or unhealthy life style that can cause increase of glucose levels in the blood. 

According to Diabetes Canada, patients with type 1 diabetes should aware of the number of insulin injections that are needed per day; the timing of insulin injections and the dose of insulin that are needed with each injection

The cause of type 1 diabetes are debatable, but some researchers found that most patient with type 1 diabetes are linked to abnormal body’s immune system over reaction to the cells that make insulin.

On the other hand, type 2 diabetes is  either caused by cells in pancreas dying off  or receptor sites clogged up by fat and cholesterol due to unhealthy dietary and life style selections.

In some cases, the diseases is also caused by allergic reactions of cells in the immune system.

If you experience some of physical symptoms of frequent urination, excessive thirst, unexplained weight loss, nonrefractive visual impairment and appetite problems,  together with gastrointestinal symptoms such as stomach pain, heartburn, diarrhea, constipation, nausea and vomiting and mental symptoms of  depression, emotion stress, sleeping difficulties,.....  and suicidal ideation, you may have type 2 diabetes. Please check with your doctor as soon as possible(4).

According to the 2011 statistic from National Diabetes Information Clearinghouse (NDIC), among U.S. residents ages 65 years and older, 10.9 million, or 26.9 percent, have diabetes in 2010.

About 215,000 people younger than 20 years had diabetes—type 1 or type 2—in the United States in 2010.

And approximately, 1.9 million people ages 20 years or older were newly diagnosed with diabetes in 2010 in the United States.

For my years of practice and research, I do believe that intake of 1/4 table spoon of Vietnamese cinnamon powder in the morning and evening have significant effects in keeping blood sugar in check.

In prediabetes with the morning reading of 6.9 emmol/L of a lady whom I know for 10 years, intake of the volume of cinnamon suggested above has managed to maintain her's the morning blood glucose at 5.3 mmol/L since.

Cinnamon, a kitchen spice used  in many cultures, may have gained many believers, including medical professions because of its anti diabetic effect, through regulating the blood glucose levels in healthy and diabetic subjects.

According to herbalists, intake of 1/4 tsp. in the morning and evening may reduce the blood sugar significantly with little or no adverse side effects.

The herb has been use in herbal and traditional medicine as anti-fungal and bacteria activities and  improves reproductive organ, prevents flatulence and intestinal cramping, treats indigestion, diarrhea, bad breath, headache, migraine, etc.(1).

In a total of 66 patients with type 2 diabetes study conducted by Xuhui District Central Hospital, researchers found that oral administration of cinnamon  reduced significant of blood triglyceride levels even in the low-dose group, after 3 months.(2).

Some researchers suggested that cinnamon extract improved fasting blood glucose levels and glucose tolerance without altering the insulin secretion may be attributed to its effects in lowering triglyceride and increasing liver glycogen content and improving insulin action in liver tissues(3).

Dr. Kim SH and Dr. Choung SY. told PubMed that “the effect of cinnamon significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR-medicated glucose and lipid metabolism”(4).

Peroxisome proliferator-activated receptors (PPARs) including PPARα, PPARγ, and PPARβ/δ are receptors that reduce triglyceride level and regulate energy homeostasis.
In support of the above, chromium(Cr) and polyphenols found in cinnamon(Cinnamomon cassia) displayed a significant improvement of glucose, insulin, cholesterol and HbA1c in patients with type 2 diabetes, according to a double-blind placebo-controlled study(7).

Unfortunately, according to the Western University of Health Sciences, even though consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose, but high degree of heterogeneity including quality and content may limit the ability to apply these results to patient care, due to the unclear preferred dose and duration of therapy(5).

Moreover, a randomized clinical trial in which 70 Patients with type II diabetes were assigned randomly into two groups (35 in cinnamon and 35 in placebo group) for the testing of the effect of cinnamon on the glucose level in blood, at the end of the experiment researchers found that there is an insignificant effect of using cinnamon on glucose level of diabetic patients and the herb should not be recommended to patients with type II diabetes depending on further studies(6).

Taken altogether, although there are some discrepancies involving cinnamon efficacy, I do believe that cinnamon in low dose is effective to control and mamage the level of blood glucose in patient with diabetes without altering the insulin level.

However, according to Dr. Georgakopoulou EA(7), oral intake of cinnamon may cause Stomatitis, and burning sensation in mouth if it is taken in large amounts.

The traditional Chinese medicine also indicated that overdoses of cinnamon can be toxic and damage the liver(1).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) @Popular Herbs -Cinnamon
(2) Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes by Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y.(PubMed)
(3) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(4) Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice by Kim SH1, Choung SY.(PubMed)
(5) Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis by Allen RW1, Schwartzman E, Baker WL, Coleman CI, Phung OJ.(PubMed)
(6) The Effect of Cinnamon on Glucose of Type II Diabetes Patients by Hasanzade F1, Toliat M2, Emami SA3, Emamimoghaadam Z(PubMed)
(7) Chromium and polyphenols from cinnamon improve insulin sensitivity by Anderson RA.(PubMed)
(8) Diabetes – The Symptoms by Kyle J. Norton

The Pungent Spice That Crucifies Breast Cancer Cells, Scientists Reveal

By Kyle J. Norton, Scholar, Master of Nutrition

The finding of whole food medication by scientists all over world to replace the single ingredient of Western medicine for treatment of breast cancer with little or no side effect has been difficult due to no commercial benefits and patent right to producers.

Breast cancer is a medical and chronic condition characterized by irregular cells growth in the breast tissue.

In most cases, breast cancer (malignant breast neoplasm) starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

There is also rare cases that breast cancer starts in other areas of the breast.

According to statistic,  in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.

Depending to the stage of cancer, women in the very early stage (increased risk of breast cancer) may only experience rusting at the nipple, bloody nipple drainage, a retracted, flattened nipple, particularly in those symptoms that do not go away in 2 weeks.

In the early stage of breast cancer, the tumor is smaller than the approximate size of a peanut (2 centimeters or smaller) and localized.

The survival rate of women diagnosed at this early stage is 100%.

In the breast cancer stage, according to the American Cancer Society, any of the following unusual changes in the breast can be a symptom of breast cancer such as  swelling of all or part of the breast,  skin irritation or dimpling. breast pain, nipple pain or the nipple turning inward. redness, scaliness, or thickening of the nipple or breast skin. 

Therefore, regardless to breast cancer risk, self examination is one the best method to detect early breast cancer. All woman should be herself looking at and feeling each breast for possible lumps, distortions or swelling monthly,

Some researchers suggested that women with alternated genes and family history of breast cancers might be required to have their mammogram taken annually.

Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia.

The food or herb has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc.

According to study, administration of fresh Garlic Extract only exerted a significant effect in inhibited colon and gastric cancer, but also stimulated cancer cell cycle arrest and alternated the morphology of MCF7 breast cancer cells.

In MCF7 human breast cancer cells, garlic constituent diallyl trisulfide have highly effective antitumor effects by suppressing viability of cultured MCF-7 and MCF-12a cells, through decreased the percent of cells in G(2)/M and induced apoptotic cell death.

According to the study by the 201 South University Street, diallyl trisulfide, inhibited the expression of MDA-MB-231 and MCF-7 breast cancer cells,regardless to the state of estrogen in the tumors.

In a total of in 285 women (aged 25-65 years old) newly diagnosed with histopathologically confirmed breast cancer, dietary Allium Vegetables has a negative association between the consumption of raw onion and risk of breast cancer.


Dr. Roy N., the lead author at the Kerala Agricultural University, said, "Docking studies and ADMET evaluation revealed twelve compounds (isolated from garlic) to be active against the targets(breast caner cell lines). All the compounds displayed highly negative dock scores which indicated good interactions".

These results suggested that the effectiveness of garlic in reduced risk and treatment of breast cancer is probably due to existence of many phytochemicals found in the herb.

Adding garlic intake to your daily diet can ameliorated risk of breast cancer substantially.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca



Kyle J. Norton, Scholar, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Fresh Garlic Extract Induces Growth Arrest and Morphological Differentiation of MCF7 Breast Cancer Cells by Modem S1, Dicarlo SE, Reddy TR.(PubMed)
(2) Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells by Malki A1, El-Saadani M, Sultan AS.(PubMed)
(3) Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells by Kiesel VA1, Stan SD2.(PubMed)