The Inter Relation of Free Radicals, Antioxidant Enzymes and Dementia (Lou Gehrig's Disease(Amyotrophic Lateral Sclerosis))

Kyle J. Norton (Scholar)


Dementia is a condition of neurodegeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgment. Over 47 millions of worldwide population are affected by the disease, mostly in the West.

The evaluation of the diseases by holistic medicine has been lacking, especially through conventional medicine research and studies.

Maintaining a balanced ratio of antioxidant and free radicals is essential for our body to perform a daily physiological function properly.

Truly, if our body is overwhelmed by overexpression of free radicals, it will be weakened by oxidative stress, causing adversely altered lipids, proteins, and DNA that can trigger a number of human diseases(a), including dementia.

* Free radicals are unstable molecules that contain at least an unpaired electron with function as oxidants or reductants by donated an electron to or accept an electron from other molecules to exhibit chain and domino's effects.

Most common oxygen-containing free radicals found epidemiologically in induced chronic diseases, including hydroxyl radical, superoxide anion radical, hydrogen peroxide, oxygen singlet, hypochlorite, nitric oxide radical, and peroxynitrite radical.

According to the University of Texas Medical Branch, observation of patients with amyotrophic lateral sclerosis (ALS) indicated that free radicals play a role in the expression of amyotrophic lateral sclerosis (ALS) through the alternation of \gene containing Cu,Zn superoxide dismutase (Cu,Zn-SOD).

Dr. Liu D said, "The selective degeneration of motor neurons in ALS may be caused by the high level of Cu,Zn-SOD present in and a large number of glutamatergic synapses projecting to these neurons"(b).

These selections of free radical in degeneration of motor neurons in ALS were attributed to free radical(mutation of Cu,Zn superoxide dismutase (Cu,Zn-SOD)) in long-term induction of oxidative stress, according to the study involved167 ALS patients (aged 59+/-13 years), treated or not with riluzole, compared with 62 age-matched healthy control subjects (aged 60+/-11 years) simultaneously, conducted by Hôpital de la Salpêtrière(c).

Some researchers suggested that cell damage and homeostatic disruption caused by free radicals can be inhibited by targeting free radicals of all kinds of molecules in the body(a), including lipids, nucleic acids, and proteins, through improving antioxidant status in the body.

* Antioxidants is a natural compound with function in inhibited molecules that cause oxidation before they can induce chains of domino's reaction.

* Antioxidants include those are produced by body tissue enzymes and externally dietary antioxidants intake from functional food sources.

Here is the summary of "The Battles of Free Radicals, Antioxidant Enzymes and Dementia (Lou Gehrig's Disease(Amyotrophic Lateral Sclerosis))"

Free radicals and Dementia (Lou Gehrig's disease)
Researchers found that glutamate in the synapses enhances the production of free radicals(77), due to its excitotoxicity, only in motor nerve cells but spares other nerve cells(74)(75) such as cells control senses and other body functions, causing disruption of astrocytes in regulated glutamate levels(76).

Antioxidants and Dementia (Lou Gehrig's disease)
1. Vitamin B12 (methylcobalamin)
High doses of vitamin B12 as an antioxidant have shown to improve or slow muscle wasting in the later stages of patients with ALS disease(78)(79).

2. Vitamin E
Vitamin E protected against cell membranes from lipid peroxidation damage(80) in reducing the risk of breakdown of the cell membrane cause of ALS(81).

3. Superoxide dismutase enzyme
Mutations in the superoxide dismutase enzyme can increase the risk ALS(82) in catalyzing the dismutation of superoxide into oxygen and hydrogen peroxide(83).

4. Cerebral cortex
Oxidative stress and DNA alternation triggered neurons damage(84) were found in elevated levels in mice with ALS(85).

5. Amino acids
Diet high in amino acids as antioxidants have shown some promising effect in treating ALS(86)(87).

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Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
(a) Free radicals, antioxidants and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra(PMC)
(b) The roles of free radicals in amyotrophic lateral sclerosis by Liu D(PubMed)
(c) Blood oxidative stress in amyotrophic lateral sclerosis by Bonnefont-Rousselot D1, Lacomblez L, Jaudon M, Lepage S, Salachas F, Bensimon G, Bizard C, Doppler V, Delattre J, Meininger V(PubMed)
(74) System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice by Mesci P1, Zaïdi S1, Lobsiger CS1, Millecamps S1, Escartin C2, Seilhean D1, Sato H3, Mallat M1, Boillée S4.(PubMed)
(75) Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase by Lewis KE, Rasmussen AL, Bennett W, King A, West AK, Chung RS, Chuah MI1.(PubMed)
(76) Mutant disrupted-in-schizophrenia 1 in astrocytes: focus on glutamate metabolism by Abazyan S1, Yang EJ, Abazyan B, Xia M, Yang C, Rojas C, Slusher B, Sattler R, Pletnikov M.(PubMed)
(77) Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia by Globus MY1, Alonso O, Dietrich WD, Busto R, Ginsberg MD.(PubMed)
(78) Methyl Vitamin B12 but not methylfolate rescues a motor neuron-like cell line from homocysteine-mediated cell death. by Hemendinger RA1, Armstrong EJ 3rd, Brooks BR.(PubMed)
(79) [Clinical trials of ultra-high-dose methylcobalamin in ALS].[Article in Japanese] by Izumi Y1, Kaji R.(PubMed)
(80) Antioxidant effect of 4-nerolidylcatechol and α-tocopherol in erythrocyte ghost membranes and phospholipid bilayers. by Fernandes KS1, Silva AH, Mendanha SA, Rezende KR, Alonso A.(PubMed)
(81) Vitamin E serum levels and controlled supplementation and risk of amyotrophic lateral sclerosis by Michal Freedman D1, Kuncl RW, Weinstein SJ, Malila N, Virtamo J, Albanes D.(PubMed)
(82) Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes by Pratt AJ1, Shin DS1, Merz GE2, Rambo RP3, Lancaster WA4, Dyer KN3, Borbat PP5, Poole FL 2nd4, Adams MW4, Freed JH5, Crane BR2, Tainer JA6, Getzoff ED7.(PubMed)
(83) Hydrogen peroxide induce modifications of human extracellular superoxide dismutase that results in enzyme inhibition by Gottfredsen RH1, Larsen UG, Enghild JJ, Petersen SV.(PubMed)
(84) Oxidative DNA damage and alteration of glutamate transporter expressions in the hippocampal Ca1 area immediately after ischemic insult.by An SJ1, Kang TC, Park SK, Hwang IK, Cho SS, Chung MH, Won MH.(PubMed)
(85) Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis.by Matus S1, Lopez E, Valenzuela V, Nassif M, Hetz C.(PubMed)
(86) Amino acids as biomarkers in the SOD1(G93A) mouse model of ALS.by Bame M1, Grier RE, Needleman R, Brusilow WS.(PubMed)
(87) Branched-chain amino acids and amyotrophic lateral sclerosis: a treatment failure? The Italian ALS Study Group.[No authors listed](PubMed)

The Whole Foods and Vegetables That Dissolve Chemical Carcinogens Before They Can Cause Cancers

By Kyle J. Norton, Scholar, Master of Nutrients

Cruciferous vegetables with rich of phytochemcals may be the potential foods that dissolve chemical carcinogens toxic effect before they can induce onset of cancers, some scientists suggested

Cancers are class of medical condition characterized by cells growth disorderly and uncontrollably in any tissue and organs in the body. In most cases, at the later stage, cancerous cells can travel a distance away to infectious other healthy cells and tissue.

Chemical carcinogens are types of chemical compounds that can cause cancer, mostly man-made.

According to the Universidade Federal de Ouro Preto, sulforaphane (SFN),the isothiocyanate (ITC) group of organosulfur compounds found in cruciferous vegetable expressed chemopreventive properties involved detoxification processes of chemical carcinogens.

Certain chemicals, such as benzene, beryllium, asbestos, vinyl chloride, and arsenic are known to induce human carcinogens.

This is tough to believe that exposure to chemical carcinogens in the outdoors, at home, and at work are associated to increase risk of getting cancer.

According to the Agency for Toxic Substances and Disease Registry, "More than 100,000 chemicals are used by Americans, and about 1,000 new chemicals are introduced each year" and "These chemicals are found in everyday items, such as foods, personal products, packaging, prescription drugs, and household and lawn care products"(4).

The agency also suggested that some chemical carcinogens can be harmful, not all contact with chemicals is dangerous to health(4).

Risk of developing cancer is depended totally  on how much, how long, how often, and when you are exposed to these chemicals.  

It is true, long term in contact with chemical carcinogens can lead to DNA alternation, the main cause of early onset of cancers(4).

Some researchers suggested that asbestos, nickel, cadmium, radon, vinyl chloride, benzidene, and benzene may act alone or with other carcinogens to increase the prevalent risk(4)

Occasional exposure to chemicals in adults  may be harmful to health, but to induce gene change is impossible.

However, when you are exposed is important because a small exposure in the womb, for example, may be more serious than a small exposure as an adult.

Dr. de Figueiredo SM, the lead author said, " In a dose dependent manner, ITC inhibits the viability of human cancer cells, modifies epigenetic events that occur in cancer cells and present antiinflammatory effect acting during the initial of uncontrolled cell proliferation." and "Chemical carcinogens are types of cancer caused by chemical toxins in induction of cellular and chromosomes change, DNA damage,... ".

The chemoprotective activity of the vegetable is the result of the significant expression of the antioxidants in exhibited cell cycle arrest and apoptosis in cancer cells as well as acting as the post-initiation stages of carcinogenesis, as a 'suppressing' agent involving the ability to modulate the Nrf2 in reduced damage from oxidative damage.

In fact, besides used as chemopreventive agent against chemical carcinogenesis, sulforaphane (SFN),the major chemical constituent of cruciferous vegetables also inhibited the drug-metabolizing enzymes that cause activation/neutralization of carcinogenic metabolites and protected normal healthy cells from environmental toxin induced of cancers.

Furthermore, the phytochemical exhibited the molecular mechanisms responsible for the overall chemopreventive effects on selective cytotoxicity, in reduced oxidate stress, free radicals produced by lipid peroxidation in cells.

In the study of tobacco smoke carcinogens induced chemical tumors, cruciferous vegetable consumption has shown to inversely associate the development of cancer.

In animal experiments. the chemopreventive effects of isothiocyanates, another compound found in cruciferous vegetable, inhibited the metabolic activation of carcinogens by cytochrome P450s, enzymes with function in metabolized potentially toxic compounds.

Taking together, intake of cruciferous vegetables have a potential health benefits against environment toxins in cancer development, but due to small size of the sample, further studies are necessary to address its viability.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Chemoprotection by sulforaphane: keep one eye beyond Keap1 by Myzak MC1, Dashwood RH.(PubMed)
(2) The antioxidant properties of organosulfur compounds (sulforaphane) by de Figueiredo SM1, Binda NS, Nogueira-Machado JA, Vieira-Filho SA, Caligiorne RB.(PubMed)
(3) Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane by Sharma R1, Sharma A, Chaudhary P, Sahu M, Jaiswal S, Awasthi S, Awasthi YC.(PubMed)
(4) Chemicals, Cancer, and You by Agency for Toxic Substances and Disease Registry

****** Cayenne, A Spice That Blocks Airway Inflammation, Scientists Reveal

Kyle J. Norton, Master of Nutrition

Scientists in numbers of institute suggested that cayenne, a kitchen spice may process a significant effect in inhibited airway inflammation, an important component of asthma, chronic obstructive pulmonary disease (COPD), and the various cough syndromes.

Conventional medicine has synthesized the effect of many of herbal plants' secondary metabolites, since the discovery of penicillin, the first antibiotic extracted from a very primitive plant, the fungus Penicillium, in 1928, used for treatment of infection.

In years, herbalist are suspicious that these plants must contain some substances used together for healing purposes, without knowing the existence of each single ingredient.

Today, under microscopes of new technology, scientists discovered that effectiveness of herbal plants in treatment of conditions and diseases are attributed to their's secondary metabolites.

Secondary metabolites are organic compounds, according to Massachusetts Institute of Technology that serve(7)
* As competitive weapons used against other bacteria, fungi, amoebae, plants, insects, and large animals.

* As metal transporting agents.

* As agents of symbiosis between microbes and plants, nematodes, insects, and higher animals.

* As sexual hormones; and 

* As differentiation effectors.

for survival of the plants producing them, 

Following the herbalist food step and used herbal medicine as a fundamental source, conventional medicine has discovered numbers of single ingredient medication, including quinine (from cinchona bark), and morphine (from the opium poppy)......

According to the Dr. Stanley F. Malamed, the lead author in the study of  causative factors for acute asthma suggestion, "(In acute airway inflammation) Inflammation may occur as a result of either immunologic or nonimmunologic airway insults, which produce airway edema and cause the immigration of inflammatory cells into the lumen through the epithelium "(5)

Chronic airway inflammation can lead to chronic obstructive pulmonary disease (COPD), a progressive syndrome caused by expiratory airflow limitation as a result of airway remodeling, including an increase in airway smooth muscle (hyperplasia and hypertrophy),......

More importantly, the longer duration of air way inflammation may lower the lung function in induction of the worse of the bronchial hyperresponsiveness and symptoms(6)

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belongings to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.

The herb or food has been used in traditional medicine to increase metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises and neuralgia, ......., particularly, in treatment of inflammation caused by invasion of microbial organisms and allergens.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases, including inflammation.

Red pepper (Capsicum baccatum) extracts, according to the study by the Federal University of Rio Grande do Sul (UFRGS), exerted its anti-inflammatory properties through in inhibiting the neutrophil migration induced by carrageenan (Cg).

In animal study, the ethanolic and butanol extracts (200mg/kg, p.o.) presented a significant anti-inflammatory activity through their antioxidant phenolic and flavonoid compounds against oxidative and inflammation-related pathological processes, including arway inflammation.

β-Defensin, members of the antimicrobial peptide found in cayenne inhibited the expression of the mRNA of anti-inflammatory cytokine during bacterial invasion, through stimulating immunomodulatory effects.

Other research suggested that anti-inflammatory effect induced by red pepper may be by inhibition of pro-inflammatory cytokine production at the inflammatory sites, such as upper airway.

Regular intake of Cayenne pepper can improve immune system against microbial infection and reduced risk of airway inflammation but overdose is found to induce toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Red Pepper (Capsicum baccatum) Extracts Present Anti-Inflammatory Effects In Vivo and Inhibit the Production of TNF-α and NO In Vitro by Allemand A1,2, Leonardi BF1, Zimmer AR1, Moreno S3, Romão PR2, Gosmann G1.(PubMed)
(2) Anti-inflammatory effects of red pepper (Capsicum baccatum) on carrageenan- and antigen-induced inflammation by Spiller F1, Alves MK, Vieira SM, Carvalho TA, Leite CE, Lunardelli A, Poloni JA, Cunha FQ, de Oliveira JR.(PubMed)
(3) Antioxidant and anti-inflammatory properties of Capsicum baccatum: from traditional use to scientific approach by Zimmer AR1, Leonardi B, Miron D, Schapoval E, Oliveira JR, Gosmann G.(PubMed)
(4) Defensin γ-thionin from Capsicum chinense has immunomodulatory effects on bovine mammary epithelial cells during Staphylococcus aureus internalization by Díaz-Murillo V1, Medina-Estrada I1, López-Meza JE1, Ochoa-Zarzosa A2.(PubMed)
(5) Learn more about Airway Inflammation(Science Direct)
(6) Why Does Airway Inflammation Persist? Is It Failure to Treat Early? by SØREN PEDERSEN(ATS Journals)
(7) The natural functions of secondary metabolites by Demain AL1, Fang A(PubMed)

Asparagus, the Veggie with Anti Oral Cancer Cells Properties

Kyle J. Norton, Master of Nutrition

Whole food(herbal medicine) used as medical treatment, linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.

But many researchers have raised question of herbal quality, because geographic differences, time of grown and harvest, etc. may effect their's potency.

Oral cancer is a medical condition characterized by irregular cells growth in the oral cavity. In the early stage, the abnormal cells only appear in the surface lining of the cavity. However, in the late stage, the infectious cells may travel a distance away from the original site to invade other cells and tissue.

Early diagnosed oral cancer may have a close to 100% recovery(3).

According to the cancer society, the 5 survival rate of oral cancer is about 60% plus without taking into consideration of the stage of cancer.

According to the Oral Cancer Foundation in the article of "Oral Cancer Fact", in US, approximately,  50000 Americans will be diagnosed with oral pharyngeal cancer this year. It will cause about 10,000 deaths.

The early symptoms of oral cancer include lip or mouth sores and persistent pain,.... Check with dentist, if you experience the above unexplained or persistent symptoms, particularly, if sore mouth does not heal in 2 weeks.

Although, the causes of oral cancers are still debatable, some researchers suggested that age, smoking, alcohol,  gender, diet,....... HPV and sun exposure are considered as  prevalent risk factors in contribution to the early onset of the cancer(3).

Dr.Payal Garg and Freny Karjodkar in the study of " “Catch Them before it Becomes Too Late”—Oral Cancer Detection. Report of Two Cases and Review of Diagnostic AIDS in Cancer Detection", said, "(Dentists and Doctors should the region with appearance of ) A red or white patch or a change in color, texture, size, contour, mobility, or function of intraoral, perioral, or extraoral tissue should arouse suspicion of the presence of malignant or premalignant lesions in these regions"

Regular intake of Asparagus may have a reduced risk and development of oral cancer, some scientists suggested.

Asparagus is a flowering plant belongings to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa and western Asia.

The veggie has been used in early times as a vegetable and medicine, because of its delicate flavour and diuretic properties.

Treatment of oral cancer in conventional medicine involved immune suppressors such as chemo drugs may contribute to complications of patients with oral cancer, such as infection.

According to University of Florida, asparagus use currently in cancer prevention rather than treatment.of oral cancer probably due to mechanism of action for bioactive compounds, such as epigallocatechin, epicatechin-3-gallate,....

Dr. the lead author said, " Preclinical and clinical evidence for the use of green tea, raspberry, asparagus, and cannabis extracts,...... diet changes, supplementation with antioxidants, high-dose vitamin C therapy, and cannabinoid use have been suggested to decrease cancer cell replication and increase chance of remission"

In the study of blood sample of 40 oral cancer patients undergoing treatment in the radiotherapy unit of Regional Cancer Institute, researchers found that arsparagus racemosus Willd. exerted a strong effect against infection caused by Staphylococcus aureus (23.2%), Escherichia coli (15.62%), Staphylococcus epidermidis (12.5%), Pseudomonas aeruginosa (9.37%), Klebsiella pneumonia (7.81%), Proteus mirabilis (3.6%), Proteus vulgaris (4.2%) and the fungal pathogens Candida albicans (14.6%), Aspergillus fumigatus (9.37%).

Researchers at the institute also suggested, oral cancer patients were neutropenic with abnormally low level of neutrophils and and prone to secondary micro infection.. Asparagus may be used as antimicrobial agent to check the secondary infections in cancer patients.

Taking altogether, asparagus has shown to exert a significant anti progression, complications and treatment of oral cancer, but further multi centers and large sample size studies are necessary to validate this claim.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Review of Various Herbal Supplements as Complementary Treatments for Oral Cancer by Godsey J1, Grundmann O1.(PubMed)
(2) In vitro antimicrobial activity of ten medicinal plants against clinical isolates of oral cancer cases by Panghal M1, Kaushal V, Yadav JP.(PubMed)

The Best Detoxification Diet, That Works, Scientists Suggest

American diet contains high saturated, trans fat, and other harmful substances such as sugar, caffeine, pesticides, additive substances, and less in fruits and vegetables.

These types of harmful substances are toxic.

Some researchers suggested that diet and exposure to environmental toxins can damage function of the mitochondria in cells in converting food to energy, affecting the organs function in protection of the body in all aspects.

The damage to mitochondria can increase over expression of free-radicals in induction of cytotoxicity to cells and tissue though a negative chain reaction

Foods that can detoxify our body against cytotoxicity include

1. Spinach
Spinach contains 

* High levels of vitamin A, E, C , the free radical scavengers with function in reduced oxidative stress by improving production of  antioxidant enzymes(1)(2).

* Numbers of trace minerals act as antioxidant in inhibited ROS species such as iron, potassium, magnesium, zinc and calcium(2). The presences of trace minerals in equate amount  are vital for a healthy heart. 

* Antioxidants,  such as lutein and beta carotene(3) strengthen our immune system and fight against the forming of free radicals. 

People with kidney disease should not eat spinach, because it is rich with oxalates.

Without drinking a lot of water or juice, intake of the veggie will increase risk of kidney stones formation.

2. Broccoli
Broccoli is high in vitamin C(1), an antioxidant that has a property in reduced the risk of inflammation and prevented forming of free radicals caused by toxins in our body. 

Study shows that some of the chemicals such as indole 3, selenium and diindolymethane have anti cancer properties and help to prevent and repair DNA damaging cells(4)(9).

3. Garlic
Garlic is a super natural food. Besides having proven record in preventing heart diseases, lower cholesterol level, elevate blood pressure(5),  it also contains high amounts of allicin, an antibody that helps to reduce inflammation and fight off degeneration caused by virus, bacteria, strengthening our immune system(6) and forming of free radicals(7).

The sulfur element helps to rejuvenate our body by increasing the function of liver in removing toxins(7).

4. Black berry
Besides vitamins C and E(1) blackberry contains anthocyanins and ellagic acid that work together in preventing inflammation, improving mental performance as well as strengthening the immune system(8). Its antioxidant function also remove accumulation of heavy metal toxins in our body(9).

5. Mellon
Mellon contains high amounts of antioxidant enzyme(9), minerals(2) and the powerful antioxidant chlorophyll(9), which is rich in antioxidants, vital minerals such as magnesium, iron, potassium, calcium, and essential fatty acids(2) with functions in removed heavy metals accumulated in the brain and toxins in our kidney(10)

6. Green tea
Green tea  balances the PH level(11) in the blood, it also contains polyphenolic catechins, a powerful antioxidant that strengthens the immune system(9), fights against free radicals building up and detoxes our body though urinary secretion(9)(12).

7.  Cooked Tomato
Tomatoes contain high amounts of alpha and beta carotene that help to strengthen the body's immune system fight off inflammation from bacteria and virus causing many types of chronic diseases(3). 

The vegetable also contains lycopene(13), a powerful antioxidant that prevents the forming of free radicals caused by accumulation of toxic substances in the body when work together with lutein(3). Be sure that the veggie is well cooked(14).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources

(1) Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats by Michael J. Ryan,1 Holly J. Dudash,1 Megan Docherty,1 Kenneth B. Geronilla,1,2 Brent A. Baker,2G. Gregory Haff,1 Robert G. Cutlip,2 and Stephen E. Alway(PubMed)

(2) Vitamins and minerals functioning as antioxidants with supplementation considerations Lee R. McDowell1 , Nancy Wilkinson, Rachel Madison and Tara Felix Department of Animal Sciences University of Florida

(3) Potential Role of Carotenoids as Antioxidants in Human Health and Disease by Joanna Fiedor* and Květoslava Burda(PubMed)

(4) Nutritional Epigenetic Regulators in the Field of Cancer by Michael Schnekenburger1, Marc Diederich2, in Epigenetic Cancer Therapy, 2015

(5) Garlic and Cardiovascular Disease: A Critical Review 

Khalid Rahman Gordon M. Lowe, The Journal of Nutrition, Volume 136, Issue 3, 1 March 2006, Pages 736S–740S,https://doi.org/10.1093/jn/136.3.736S

(6) The Immunomodulation and Anti-Inflammatory Effects of Garlic Organosulfur Compounds in Cancer Chemoprevention by Georgia Schäfer1 and Catherine H. Kaschula(PubMed)

(7) The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins by Rabinkov A1, Miron T, Konstantinovski L, Wilchek M, Mirelman D, Weiner L(PubMed)

(8) Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days by Stoner GD1, Sardo C, Apseloff G, Mullet D, Wargo W, Pound V, Singh A, Sanders J, Aziz R, Casto B, Sun X(PubMed)

(9) Free radicals, antioxidants and functional foods: Impact on human health byV. Lobo, A. Patil, A. Phatak, and N. Chandra(PubMed)

(10) Toxicity, mechanism and health effects of some heavy metals by Monisha Jaishankar, Tenzin Tseten, Naresh Anbalagan, Blessy B. Mathew, and Krishnamurthy N. Beeregowda(PubMed)

(11) Evaluation of the pH and titratable acidity of teas commercially available in Brazilian market ORIGINAL | ORIGINAL Avaliação do pH e titrabilidade ácida de chás comercialmente disponíveis no mercado brasileiro 

(12) 5 Kidney Cleansing Drinksby Dr. Group by Dr. Edward Group DC, NP, DACBN, DCBCN, DABFM

(13) Lycopene as A Carotenoid Provides Radioprotectant and Antioxidant Effects by Quenching Radiation-Induced Free Radical Singlet Oxygen: An Overview by Jalil Pirayesh Islamian, Ph.D.* and Habib Mehrali, M.Sc(PubMed)

(14) Cooking Tomatoes Boosts Disease-Fighting Power, Date:April 23, 2002 (by Cornell University)

A Beverage, That Suppresses the Incidence of Rheumatoid Arthritis (RA)

Kyle J. Norton, Master of Nutrition


Total caffeinated coffee intake daily is associated to non risk factor but attenuated risk of incidence of rheumatoid arthritis, the joint study by the Harvard Medical School and Brigham and Women's Hospital, Boston and a Asian study, suggested, respectively.

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Rheumatoid Arthritis is a chronic immune disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues in the body.

In other words, the synovial membrane that protects and lubricates joints are inflamed, causing pain and swelling. But what trigger these attacks are still debatable.

The disease affects more women than men and generally occurs after the ages of 40, causing diminished physical activity and quality of life of many people.

According to statistic, 1% of the global population are affected by the disease. In the US, based on rates of RA from a 1995 Minnesota study and 2005 Census data, the prevalent risk  is lower with  approximately 1.29 million or 0.6% of the population.

Some researchers suggested that  Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation(4). 

According to a cross-sectional population-based study of 1042 patients with rheumatoid arthritis, researchers showed that RA patients had an increased risk of death from various causes(5).

The joint study conducted lead by the University of Texas Southwestern Medical Center and Victoria Hospital, the misdiagnosis of the atypical infections versus inflammatory conditions of the hand due to some similarity to inflammatory conditions regarding their clinical and imaging finding is rare but delay diagnosis can increase risk of severe bone and joint destruction, and higher morbidity(6).

Truly, some reseachers believed that habitual coffee consumption are associated to risk of RA. 

Women who have never drunk coffee before showed an increased risk of RA if daily intake of decaffeinated coffee is over 4 cups.

Dr. Mikuls TR, the lead author said, "Decaffeinated coffee intake is independently and positively associated with RA onset" and "Further investigations of decaffeinated coffee and tea intake as arthritis risk factors are needed to verify these findings and explore their biologic basis".

However, according to the study of Korea University Anam Hospital, caffeinated or decaffeinated coffee consumption are not risk factors of RA.

In the follow up study of 83,124 women, completed the FFQ at baseline, the diagnosis of incident RA(between 1980 and 2000) with a food frequency questionnaire (FFQ) completed every 4 years, from baseline in 1980 through 1998, researchers found that
* Decaffeinated coffee consumption of >/=4 cups/day (compared with no decaffeinated coffee consumption) showed no subsequent risk of incident RA.

* There was no relationship of incidence of RA or reduced incidence RA in caffeinated coffee consumption, regardless to numbers of cup intake daily.

* Total coffee and total caffeine consumption were also not associated with the risk of RA.

And coffee intake showed a statistically clinical value in attenuated risk of RA.

According to the Korea University College of Medicine, the numbers of coffee intake daily in reduced RA incidence were substantially different in number studies.

The highest category of coffee intake in Heliovaara et al. cohort study from Finland was up to 13 cups per day, while US studies was > 4 cups coffee intake per day.

The study also emphasized that caffeine showed no significant association of RA incidence in compared to caffeinated coffee consumption in ameliorated risk RA incidence.

Furthermore, the study in valuated coffee, tea, and caffeine consumption and risk factors for rheumatoid arthritis (RA) onset among older women, indicated that risk of RA is reduced substantially with drinking > 3 cups/day of decaffeinated coffee in compared to non drinkers.

Interestingly, women who have never drunk coffee before showed an increased risk of RA if daily intake of decaffeinated coffee is over 4 cups.

Collectively, the finding evidences suggested that caffeinated coffee intake is not an independent risk factor but a reduced risk parameters for onset of rheumatoid arthritis (RA) incidence, depending to numbers of cup consumption per day.

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Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.



Sources
(1) Coffee or tea consumption and the risk of rheumatoid arthritis: a meta-analysis by Lee YH1, Bae SC, Song GG.(PubMed)
(2) Coffee, tea, and caffeine consumption and risk of rheumatoid arthritis: results from the Iowa Women's Health Study by Mikuls TR1, Cerhan JR, Criswell LA, Merlino L, Mudano AS, Burma M, Folsom AR, Saag KG.(PubMed)
(3) Coffee consumption and risk of rheumatoid arthritis by Karlson EW1, Mandl LA, Aweh GN, Grodstein F.(PubMed)
(4) Serum Sclerostin Level Among Egyptian Rheumatoid Arthritis Patients: Relation to Disease Activity ,Bone Mineral Density and Radiological Grading by Mehaney DA, Eissa M, Anwar S, El-Din SF(PubMed)
(5) Death rates and causes of death in patients with rheumatoid arthritis: a population-based study by Sihvonen S1, Korpela M, Laippala P, Mustonen J, Pasternack A(PubMed)

(6) Atypical Infections versus Inflammatory Conditions of the Hand: The Role of Imaging in Diagnosis by Soldatos T1, Omar H, Sammer D, Chhabra A.(PubMed)

Beware of The Major Side Effect of Kidney Beans Intake - Severe Intestinal Atrophy, Medline Studies Reveal

By Kyle J. Norton, Scholar, Master of Nutrition


The use of plants for healing purposes have been predated long before the existence of modern medicine.

Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Intestinal atrophy is the abnormality of small intestine mucous membrane, in most cases caused by bacterial infection.

However, certain diseases such as Celiac disease may precipitate the occurrence of intestinal atrophy.

If  a patient incidentally consume foods containing the protein gluten, the allergic foods may trigger immune over expression in attacking the intestinal villi.


Intestinal atrophy can also be caused by intake of certain medication, including immune suppressors, such as imuran, antibiotics such as neomycin, and the anti-inflammatory medication such as colcrys,........

Patients in the early stage of the condition may only experience some abdominal discomforts.

As the infection progress, infectious persons may develop diarrhea, weight loss, abdominal pain, and fatigue.

Some researchers suggested, intestinal atrophy is a serious condition, as the ‘villi’ or ‘microvilli’, damage to some extents, the condition may increase risk of  intestinal permeability and most autoimmune diseases.

According to the Josai University, glutathione (GSH), an antioxidant found in plants, animals, fungi, and some bacteria and archaea may have a profound effect in reduced expression through enhances jejunal regenerative potential to minimize intestinalmucosal atrophy by diminishing fasting-mediated ROS generation and intestinal lining cells apoptosis and enhancing cell proliferation(4)..

These result suggested that oral glutathione (GSH) administration processes a strong activity in alleviated the effects of fasting-induced intestinal atrophy in the small intestinal mucosa.

Intake of kidney beans may result in increased risk of the developed intestinal atrophy, some scientists suggested.

Kidney beans with kidney shape, strong flavor and color of reddish brown in nature are often the excellent dietary selection with no cholesterol, but a good source of protein and minerals.

According to the University of Utrecht, animal fed with kidney bean induced mucosal atrophy microscopically causing atrophy and dissection of the intestinal villus in association to lengthen crypts with cells in increased mitotic activity in compared to than normal tissues.


In compared to control, kidney bean intake significantly decreased the goblet cells in secrete gel-forming mucins, the major components of mucus but increased in the crypt region, a gland found in the intestinal epithelium lining of the small intestine and large intestine.

Dr. Kik MJ, the lead author of the study said, " feeding Phaseolus vulgaris beans reduced the digestive and absorptive capacity of the mucosa, resulting in weight loss and diarrhea in affected pigs".

In randomized study with mice fed to chow, elemental diet, elemental diet plus concanavalin-A and elemental diet plus phytohaemagglutinin groups, group fed phytohaemagglutinin showed a strong effect of chemical compound lectin in inducing cell proliferation in the small intestine and crypt fission of the middle and distal small intestine in compared to other groups.


The study also showed that phytohaemagglutinin with high amount of lectin also induced intestinal atrophy by affecting the gastric function and mobility through increased secretion of hormone in regulated gastric acid (HCl).

In fact, the effects of lectins cause of significant gastric trophy on the small intestine and colon may be vary between different sites in the gastrointestinal tract.

In support to the above analysis, the Christian-Albrechts-Universität study with 30 day old male rats pairfed for 10 days with lactalbumin as a control diet or lactalbumin plus PHA or purified soybean trypsin inhibitor (STI) as a positive control (42 mg/rat/day) with or without 20 micrograms of the cholecystokinin A (CCK-A) antagonist MK 329, researchers found that oral administration of phytohaemagglutinin (PHA) in rats dose dependently induces growth of the small intestine through significantly increased CCK plasma levels from 0.75 to 6.67 (SEM 2.23) compared with 2.3 (0.35) pM in the control group.

The result of phytohaemagglutinin (PHA) intake in exhibit the intestine atrophy may be attributed to the lectin levels in increased production of hormone cholecystokinin in stimulated additional release of bile into the intestine.

Taking together, intake of kidney bean should be taken with care with patients with digestive problems as level of lectin may induce intestinal atrophy.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Pathologic changes of the small intestinal mucosa of pigs after feeding Phaseolusvulgaris beans by Kik MJ1, Huisman J, van der Poel AF, Mouwen JM(PubMed)
(2) Lectins can reverse the dsstal intestinal atrophy associated with elemental diets in mice M by SASAKI*, A. J. FITZGERALD*, G. GRANT , M. A. GHATEIà, N. A. WRIGHT* & R. A. GOODLAD§(Wiley online Library)
(3) Red kidney bean lectin is a potent cholecystokinin releasing stimulus in the rat inducing pancreatic growth byK-H Herziga, S Bardoczc, G Grantc, R Nustedeb, U R Fölscha, A Pusztaic(BMJ Journals)