Herbal Therapy: Herbal Anise in Ameliorated Risk and Treatment of Functional Dyspepsia

Kyle J. Norton 


Anise may have a potential and substantial effect in reduced risk and treatment of functional dyspepsia (FD), some scientists suggested.

Anise is a flowering plant ofthe species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to to Egypt and the Mediterranean region,  used in traditional herbal medicine as fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, ....

Chemical comstituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

Functional dyspepsia (FD) is a chronic disorder characterized by sensation and movement (peristalsis) in the upper digestive tract.

In the study of total of 180 patients attending the gastroenterology clinic, 107 ones with the diagnosis of postprandial distress syndrome according to Rome III criteria, randomly assigned to anise group of 47 patients received anise powders, 3 g after each meal (3 times/day) for 4 weeks and placebo group of 60 patients received placebo powders (cornstarch), 3 g after each meal (3 times/day) for 4 weeks researchers at the joint study lead by the Iran University of Medical Sciences indicated that

Anise treatment scored a significant improvement of all domains of SF-36(The Short Form (36) Health Survey) at week 12 in compared to placebo group, although both groups scored a similar at the baseline.

More specifically, at week 12, the mean of physical component score was 141 in placebo group and 251 in Anise treatment group in compared to the base line scores of 159 and 167, respectively and the mean mental component scores at weeks 12 was 135 in placebo group and 233 in anise group in compared to 172 and 165 respectively.

Domain of SF-36  completed by the patients includes vitality, physical functioning, bodily pain, general health perceptions, physical role functioning, emotional role functioning, social role functioning, and mental health,  used widely in managed care organizations and  medicare for routine monitoring and assessment of care outcomes in adult patients. The lower the score is an indication of more disability in compared the higher the score of less disability.

The strong improvement of physical and mental scores in the Anise group in compared to the base line and placebo may be associated to Anise in contributed to increase quality of life in patients of functional dyspepsia, through reduction of symptoms intensity.

Further differentiation, in a total of 107 patients attending the gastroenterology clinic, aged 18-65 years, diagnosed with PDS according to ROME III criteria, randomly assigned to group of 47 patients receive either received anise powders, 3 g after each meal (3 times/day) or placebo involved 60 patients and received placebo powders (corn starch), 3 g after each meal (3 times/day) for 4 weeks.  researcher found that anise group expressed a significant effect in reduced all symptoms at weeks 4 and 12, but retching, nausea and vomiting in compared to control group and at the baseline.

The examine of the mean total scores of FD severity scale in anise group also expressed improvement at weeks 2, 4 and 12 in compared to insignificantly different of the two groups before the intervention.

Anise intervention also demonstrated a decreased significantly of mean severity scores of epigastric fullness, epigastric discomfort, epigastric burning/pain, early satiety, bloating, belching, and loss of appetite in compared to epigastric pain, epigastric fullness and belching increased significantly in the placebo group after intervention.

Moreover, Anise group also exerted a strong improvement of  mean of pain score in compared to placebo, probably as a result of its anti spasmolytic feature.

However, after taking into account of other co founders such as factors in causes of FD and  anise effects on broad spectrum of pharmacological effects on GI, nervous, muscular and immune systems, researchers concluded that there are no surprise that Anise application showed a significant improvement of symptoms in patients with FD.

The information findings may be astonished, but the study also found to induce certain limitation, including limited the external validity of the results with a small sample size and shorted follow up periods.

Taking together, herbal Anise not only improve quality of life in patients with  functional dyspepsia but may also be considered as adjunct therapy in combined with conventional standard medicine for reduced symptoms and treatment of functional dyspepsia. 

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Pimpinella anisum in modifying the quality of life in patients with functionaldyspepsia: A double-blind randomized clinical trial by Ghoshegir SA1, Mazaheri M2, Ghannadi A3, Feizi A4, Babaeian M5, Tanhaee M3, Karimi M6, Adibi P7.(PubMed)(PMC)
(2) Pimpinella anisum in the treatment of functional dyspepsia: A double-blind, randomized clinical trial by Ghoshegir SA1, Mazaheri M2, Ghannadi A3, Feizi A4, Babaeian M5, Tanhaee M3, Karimi M6, Adibi P7.(PMC)

Alternative Therapy: Yoga Intervention in Reduced Risk and Symptoms of Pregnant Lumbopelvic Pain

Kyle J. Norton 

Yoga therapy may be used as secondary integrated form of exercise for reduced symptoms, risk and treatment of lumbopelvic pain in pregnant women, a Brazil university study suggested.

Lumbopelvic pain is condition of pain in the lumbar and/or sacro-iliac area and pelvic girdle, the most common diagnosis among women in pregnancy.

Approximately, over half of all pregnant women and one-quarter of postpartum women are reported to experience lumbopelvic pain, according to statistic.

Yoga, the ancient technique for harmonized external and internal body well beings, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In a randomized controlled trial with 60 pregnant women (age range, 14-40 years) reported lumbopelvic pain at 12 to 32 weeks of gestation conducted from June 2009 to June 2011, divided in to yoga and postural orientation group, researchers at the Universidade Estadual de Campinas found that after 10 weeks, the median pain score is lower in the median pain score yoga group in compared to postural orientation group and pregnant women in the yoga group also experience intensified pain reduction gradually during 10 yoga sessions.

Truly, yoga mindfulness in induced stress reduction relaxed the central nervous system in response to stress hormone production through activated hormone prostaglandins PE2  and initiated nitric oxide synthase in over expression of nitrous oxide in induced lumbopelvic pain through promoted muscle constriction in the infected region.

The reduction of nervous tension also modulated and normalized the steady increased production of hormone estrogen, progesterone and relaxin depending to months of gestation to facilitate the health of the mother and growth of the fetus.

Deficiency of above hormones are found in  pregnant women with severed state of lumbopelvic pain.

Additionally, the relaxed central nervous system not only reduced production of stress hormones but also normalized production of melatonin and dopamine in controlling sleep regulation.

Further more, yoga posture practice improved the flexibility of motion atterns of flexure and rotation of the trunk and the trunk muscles also have a significant effect in sensitive motor pathway and decreased changes in the sensory system in driving sensitive muscles and heighten pain through influencing the neuro system in coordinate with information feed back of related body position and movement from active and passive system from sensors nerve ending in the muscle, tenders, joint capsules and fascia, thus ameliorating over expression of motor pathway in transmitting sensitive information in induction of lumbopelvic pain. 

The relaxation and meditation of yoga also connected and balanced the mind and body, by bringing back the presence of unfavorable experience of previous pain and fear avoidance beliefs..... while letting them go or dealing them in a positive ways, thus improving the emotional and cognitive health.

These results also reduced other medical conditions such as arthritis, migraine and often pelvic pain associated in pain sensitivity, a phenomenon known as pregnancy-induced analgesia, the inability to feel pain.

Moreover, yoga relaxation and meditation technique restored the natural consciousness of pre motherhood with love and care of the offspring and increased sense of closeness to the baby also enhanced automatically the circulatory function in moving more blood to the lumbopelvic region, thus reducing pain caused by vessels and muscles constriction and  promoting positive emotion and cognitive function..

The above differentiation were support by the study in examine the database of published studies from January 2004 to February 2014 with 10 randomized controlled trials satisfied the criteria and guideline were selected conducted by the joint research lead by University of Gothenburg.

Researchers after adjusting to other co founders, suggested that
*Yoga intervention expressed a lower incidences of prenatal disorders (p ≤ 0.05), and small gestational age (p < 0.05), lower levels of pain and stress
*. Yoga group showed an higher score of relationship
*. Yoga may be considered as a safe therapy used for pregnant women who are depressed, at high-risk, or experienced lumbopelvic pain

Dr. Gutke A, the led author said," (Although, there were no specific adverse events were reported for any intervention, but limited evidences), caution should prevail in choosing other interventions for pregnancy-related lumbopelvic pain".

Taking altogether, Yoga intervention may be considered as integrated form of therapy in reduced risk of pregnant lumbopelvic pain  and combined with standard treatment in lower symptoms in these group of women.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton (Scholar, Master of Nutrition All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Treatment of pregnancy-related lumbar and pelvic girdle pain by the yoga method: a randomized controlled study by Martins RF1, Pinto e Silva JL.(PubMed)
(2) Treatments for pregnancy-related lumbopelvic pain: a systematic review of physiotherapy modalities by Gutke A1,2, Betten C3, Degerskär K4, Pousette S5, Olsén MF1,6.(PubMed)
(3) Effects of yoga intervention during pregnancy: a review for current status by Jiang Q1, Wu Z2, Zhou L1, Dunlop J3, Chen P1.(PubMed)

Food Therapy: Fennel or Its Composition as Laxative Agent for Treatment of Chronic Constipation

Kyle J. Norton

Fennel may have a therapeutic effect for treatment of chronic constipation, some scientist suggested.

Chronic constipation is condition characterized by infrequent bowel movements in passing stool for weeks at a time.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.

According to the study of 24 patients with chronic non-specific colitis conducted by Dr. Chakŭrski I, and colleagues, oral administration of traditional combination of peppermint, licorice and fennel exerted a significant activity in reduced spontaneous and palpable pains along the large intestine disappeared and induced daily defecation in the patients with obstipation syndrome.

Further differentiation suggested that the herbal formula demonstrated a potential effect in inhibited the colitis expression in reduced the colon function in reabsorbed fluids and processed waste products from the body and prepared for its elimination.

Some researchers suggested chronic constipation may be an intestinal microbiota imbalance related disease as herbal feed additive including fennel exerted significant effects in digestive disorders of  weaning rabbits' intestinal microbiota, accoridng to the study in compared the differences in the composition of the intestinal microbiota in constipated patients and healthy controls.

In fact, further analysis also found that patients with chronic constipation expressed alterations of intestinal microbiota composition characterized by decreased obligate bacteria (e.g. Lactobacillus, Bifidobacterium, and Bacteroides spp.) and a parallel increase of potentially pathogenic microorganisms (e.g. Pseudomonas aeruginosa and Campylobacter jejuni).

Long term imbalance of  intestinal microbiota composition may associate to the prevelence of chronic constipation as increased pathogenic microorganisms may reduce intestinal motility and secretory functions by changing the amount of available physiologically active substances and the metabolic environment of the gut in the breakdown of food products into absorbable nutrients.

The above differentiation of fennel composition effect was supported by illustration of the study of  formula Smooth move, a herbal tea used in some nursing care for residents with chronic constipation.

According to Dr. Bub S and colleagues in a total of 86 nursing home residents with chronic constipation randomly assigned to receive Smooth Move (n = 42) or a placebo (n = 44), once daily, in addition to standard treatment for chronic constipation for 28 days, oral administration of the formula showed a statistically significant increase in the number of bowel movements in compared to placebo group.

More precisely, participants treated with Smooth Move in compared to non treatment group experienced an average of 4.14 more bowel movements during the 28-day study period versus the 28-day pre-study period.

Interestingly, in the investigation of the laxative efficacy of composition of Pimpinella anisum L., Foeniculum vulgare Miller, Sambucus nigra L., and Cassia augustifolia used in Brazil for treatment of chronic constipation, researchers at the institution of conducted a randomized, crossover, placebo-controlled, single-blinded trial included 20 patients presenting with chronic constipation according to the criteria of the American Association of Gastroenterology, found that patients received the formula composition exert a strong improvement of bowel function in compared to control.

However, the application fails to improved quality of life in participants in reduced some symptoms associated to chronic constipation, excepted for a small reduction in serum potassium levels during the active treatment.

Dr. Picon PD, the lead author, after taking into account of other con founders, said, "phytotherapic compound assessed has laxative efficacy and is a safe alternative option for the treatment of constipation".

Taken together, fennel used alone or combined with other herbal medicine may be considered as a therapeutic treatment in patients with chronic participation without inducing any intolerable side effects.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

Arthritis Is Curable

You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) [Treatment of chronic colitis with an herbal combination of Taraxacum officinale, Hipericum perforatum, Melissa officinaliss, Calendula officinalis and Foeniculumvulgare].[Article in Bulgarian] by Chakŭrski I, Matev M, Koĭchev A, Angelova I, Stefanov G.(PubMed)
(2) Efficacy of an herbal dietary supplement (Smooth Move) in the management of constipation in nursing home residents: A randomized, double-blind, placebo-controlled study by Bub S1, Brinckmann J, Cicconetti G, Valentine B.(PubMed)
(3) Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronicconstipation by Picon PD1, Picon RV, Costa AF, Sander GB, Amaral KM, Aboy AL, Henriques AT.(PubMed)
(4) Intestinal microbiota and chronic constipation by Ying Zhao and Yan-Bo Yu(PubMed)
(5) Performance, digestive disorders and the intestinal microbiota in weaning rabbits are affected by a herbal feed additive by R. Krieg, Wageha Awad, W Vahjen and Wilfried Vahjen(Research gate)

8 Science Base Delicious Vegetables in Attenuated Risk, Progression and Treatment of of Breast Cancer

Kyle J. Norton

The prevalence of breast cancer has been acknowledged in the scientific community worldwide.

Breast cancer widespread in women in Southeast Asian as a result of over 2 decades of economic prosperity caused by unhealthy diet is a major concern.

The findings for effective treatments are ongoing with some successes, but discovery of effective ingredients prevention and treatment of breast cancer with little or no side effects have proven difficultly.

According to statistic, the risk of getting invasive breast cancer during life time of a woman is 1/8.

Detection of tumorigenesis through self observation are still the best approach to discover breast cancer in early stage.

But reduction of the mortality at late stage discovered breast cancer has not been accounted, even with extensively modern technology in the field of diagnosis and insurance protection in Western world, needless to say of those countries with poor health care system.

Suggestions of healthy diet with plenty vegetables and fruits(1)(2)(3) accompanied with change of life style(4)(5)(6) may be the only choice for women in reducing risk of the disease.

In fact, certain vegetables(7)(8), fruits(9)(10) and bioactive phytochemicals found in foods(23)(24) and herbs(33)(34) have been found to induce apoptosis and anti proliferation of breast cancer cells by blocking the energy sources to the tumor site and suppressing the promoted cancers genes.

1. Cruciferous vegetables
Cruciferous vegetables are the group of vegetables belongings to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.

Isothiocyanate (ITC), one of the major chemical constistuent found in cruciferous vegetables has been studied extensively over the past three decades with evidence against breast cancer in preclinical models.

 Benzyl isothiocyanate, the derivative of isothiocyanate displayed  an significant efficacy in inhibited carcinogen metabolism and signaling pathways relevant to tumor progression and invasion(11) against MDA-MB-231(breast cancer dell line), human breast cancer xenografts(mutation tissues)(12) by suppressing X-linked inhibitor of apoptosis (XIAP) protein expression of cancer cell line MCF-7 and reduced levels of mutations of p53(antigens) protein level(13).

Loss of normal function of p53 gene was associated with over 50% of cancer patients and mutation p53 gene may have an oncogenic potential.

In Her-2 positive (a most aggressive case of breast cancer), indole-3-carbinol, a naturally occurring compound found in cruciferous vegetables, used combination with paclitaxel (a mitotic inhibitor) synergistically inhibited growth of Her2/neu human breast cancer cells by cancer cells cycle arrest in the G2(pre-mitotic phase) and M(nuclear division) phase and induced apoptosis/necrosis(14).

I3C used alone also inhibited Her-2breast cancer cell growth in a dose dependent manner as the compound promoted production of Bax(an apoptosis promoter) and decreased expression of Bcl-2(an apoptosis inhibitor) and, thereby, increased the ratio of Bax to Bcl-2 in favoring apoptosis(15).

2. Tomatoes
Tomato is a red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purpose and often in green house.

Lycopene, a major carotenoid component of tomato has been known in research community with the property to attenuate the risk of breast cancer.

 In a time and doses dependent, the compound showed an anti-proliferative activity against ER(estrogen receptor)/PR(progesterone receptor) positive MCF-7, HER2-positive SK-BR-3 and triple-negative MDA-MB-468 cell lines by arresting cell cycle at the G0 /G1phase(interphase together - chromosomes replicate in preparation for cell division) at physiologically achievable concentrations(range) found in human plasma(16)

Lycopene also Inhibited the ER-positive MCF-7 through cell cycle progression, ER-negative MDA-MB-231 cells through G1 phase cell cycle-arrest(17).

Application of lycopene not only restored the GSTP1 expression but also at 2 microM, once per week for 2 weeks induced demethylation of RARbeta2 (tumor suppressor gene) and the HIN-1(a cell growth inhibitor)) genes in the non cancer MCF10A fibrocystic breast cells(18).

3. Figs
N-hexane insoluble fraction (HIF) found in figs may be lesser known for its efficacy in breast cancer cell suppressive activity.

The combination of HIF and doxorubicin exerted a greater inhibition on cell growth in (Human ductal breast epithelial tumor cell line) T47D cells and increased the incidence of cells undergoing apoptosis, in compared to doxorubicin alone(19).

The soluble frarction (Ethyl acetate soluble fraction (EASF)) in fig leave was also found to enhance the cytotoxic effect of doxorubicin by changing the inhibition of cell cycle G(2)/M to G(1) phase(20).

 And Acetone extract of Ficus religosa leaf (FAE) demonstrated an irreversible inhibition of breast cancer cell growth with moderate toxicity by stimulating the loss of mitochondrial membrane potential in multiple breast cancer cell lines and accelerated cell death through the photosensitizing effect(21).

4. Garlic
Garlic is a natural superfood healer for its antibiotic antiviral, antifungal, anticoagulant and antiseptic properties.

Diallyl trisulfide(DAS), a derived organosulfur compounds (OSCs) suppressed the a ratio of viable cells in the culture of (Human breast cancer cell line) MCF-7 and MCF-12a (a non-tumorigenic epithelial cell line) by decreasing the percent of cancer cells in phase G(2)/M and induced apoptotic cell death through stimulated function of Bax protein and p53(cellular tumor antigen) protein expression(22).

Application of DAS also enhanced the effect of eicosapentaenoic acid, a breast cancer suppressor, and decreased the effect of linoleic acid, a breast cancer enhancer and reduced the side effects caused by anti-cancer agents(23).

Protein fraction from garlic was effective in inhibiting tumor growth more efficiently than garlic extract in enhancing the CD8(+) T-cell infiltration into the tumor site(24).

5. Spinach
Spinach, an edible flowering plant in the genus Spinacia, belongings to the family of Amaranthaceae, is considered as a healthy plant containing vary vitamins and minerals, native to central and southwestern Asia.

Consuming spinach was found to exhibit a significantly protective effect on breast cancer among premenopausal women(25).

Eating carrots or spinach more than twice weekly, compared with no intake, was associated with an odds ratio of 0.56 but did not distinguish among several potential explanations for the protective association observed between intake of carrots and spinach and risk of breast cancer.(26).

 It is said that included supplementation of A. gangeticus aqueous extract of red spinach at 10% reduced progression of in breast cancer in rat model(27).

6. Kelp
Kelps are large seaweeds (algae) growth under shallow in underwater of oceans belongings to the class Phaeophyceae in the order Laminariales, used for food in many cultures.

Laminaria, a brown kelp seaweed containing antibiotic substance, 1-3 beta glucan, was effective in activated host-mediated immune response in prevented  the initiation of breast cancer(28).

Japanese seaweed (Laminaria angustata) extracts was also found to exert its antimutagenic effects in certain breast and colon carcinogen(29).

L-tryptophana substances isolated from the kelp rhizoid, may play an important role in the inhibition of breast cell proliferation(30)(31).

7. Chili pepper
Chili pepper is the fruit of plant from the genus Capsicum, belongings to the nightshade family, Solanaceae, used in human history for spices and cultivated for commercial profits.

Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), a chemical constituent of chili peppers used in many cultures as anti cancer agent inhibited the growth of ER-positive (MCF-7, T47D, BT-474) and ER-negative (SKBR-3, MDA-MB231) breast cancer cell lines, reduced 50% the size of MDA-MB231 breast cancer tumors(32), through inducing cellular apoptosis via a caspase-independent pathway in MCF-7 cells(33).

In the comparison of  Dohevanil, researchers found that both vanilloids, precursor of capsaicin and dohevanil inhibited the growth of DNA fragmentation in MCF-7 cells(34).

8. Carrot
Carrot is root vegetable with orange color normally, a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

Intake of cruciferous vegetable and carrot are inversely associations with risk of estrogen receptor-negative/progesterone receptor-negative breast cancer(35).

Wild carrot or Daucus carota L. ssp. carota (Apiacea) oil extract, used in traditional medicine in Lebanon and different regions throughout the world was found to inhibit human colon (HT-29, Caco-2) and breast (MCF-7, MDA-MB-231) cancer cell lines, through apoptotic and anti proliferative activities(36).

The information findings once again emphasized the importance of healthy diet with plenty vegetables and fruits and change of life style in breast caner risk.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

1) Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women by Fung TT, Chiuve SE, Willett WC, Hankinson SE, Hu FB, Holmes MD.(PubMed)
(2) Fruits, vegetables and breast cancer risk: a systematic review and meta-analysis of prospective studies by Aune D, Chan DS, Vieira AR, Rosenblatt DA, Vieira R, Greenwood DC, Norat T.(PubMed)
(3) Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients.
Freudenheim JL, Marshall JR, Vena JE, Laughlin R, Brasure JR, Swanson MK, Nemoto T, Graham S.(PubMed)(4) Life style and risk of development of breast and ovarian cancer by Pięta B, Chmaj-Wierzchowska K, Opala T.(PubMed)
(5) Epidemiological evidence for a relationship between life events, coping style, and personality factors in the development of breast cancer by Butow PN, Hiller JE, Price MA, Thackway SV, Kricker A, Tennant CC.(PubMed)
(6) Epidemiological correlates of breast cancer in South India by Babu GR, Lakshmi SB, Thiyagarajan JA.(PubMed)
(7) Dietary organic isothiocyanates are cytotoxic in human breast cancerMCF-7 and mammary epithelial MCF-12A cell lines by Tseng E, Scott-Ramsay EA, Morris ME.(PubMed)
(8) Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype by
(9) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice.by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC.(PubMed)
(10) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)
(11) Benzyl isothiocyanate: double trouble for breast cancer cells by Rao CV.(PubMed)
(12) Inhibition of human breast cancer xenograft growth by cruciferousvegetable constituent benzyl isothiocyanate by Warin R, Xiao D, Arlotti JA, Bommareddy A, Singh SV.(PubMed)
(13) p53-Independent apoptosis by benzyl isothiocyanate in human breast cancer cells is mediated by suppression of XIAP expression by Kim SH, Singh SV.(PubMed)
(14) 3,3'-diindolylmethane and paclitaxel act synergistically to promote apoptosis in HER2/Neu human breast cancer cells by McGuire KP, Ngoubilly N, Neavyn M, Lanza-Jacoby S.(PubMed)
(15) Translocation of Bax to mitochondria induces apoptotic cell death in indole-3-carbinol (I3C) treated breast cancer cells by Rahman KM, Aranha O, Glazyrin A, Chinni SR, Sarkar FH.(PubMed)
(16) Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines by Takeshima M, Ono M, Higuchi T, Chen C, Hara T, Nakano S.(PubMed)
(17) [Effect of lycopene on the proliferation of MCF-7 and MDA-MB-231 cells].
[Article in Chinese] by Wang AH, Zhang LS.(PubMed)
(18) Modulation of gene methylation by genistein or lycopene in breast cancer cells, by King-Batoon A, Leszczynska JM, Klein CB.(PubMed)
(19) Combinational effects of hexane insoluble fraction of Ficus septica Burm. F. and doxorubicin chemotherapy on T47D breast cancer cells by Nugroho AE, Hermawan A, Putri DD, Novika A, Meiyanto E, Kawaichi M.(PubMed)(20) Synergistic effects of ethyl acetate fraction of Ficus septica Burm. f. and doxorubicin chemotherapy on T47D human breast cancer cell line by Nugroho AE, Hermawan A, Putri D P, Meiyanto E, Hakim L.(PubMed)
(21) Bax translocation mediated mitochondrial apoptosis and caspase dependent photosensitizing effect of Ficus religiosa on cancer cells by Haneef J, Parvathy M, Thankayyan R SK, Sithul H, Sreeharshan S.(PubMed)
(22) Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells by Malki A, El-Saadani M, Sultan AS.(PubMed)
(23) Anticancer effects of garlic and garlic-derived compounds for breast cancer control.
Tsubura A, Lai YC, Kuwata M, Uehara N, Yoshizawa K.(PubMed)(24) Purif ied Protein Fraction of Garlic Extract Modulates Cellular Immune Response against Breast Transplanted Tumors in BALB/c Mice Model by Ebrahimi M, Mohammad Hassan Z, Mostafaie A, Zare Mehrjardi N, Ghazanfari T.(PubMed)
(25) Food sources of phytoestrogens and breast cancer risk in Mexican women by Torres-Sánchez L, López-Carrillo L, López-Cervantes M, Rueda-Neria C, Wolff MS.(PubMed)
(26) Intake of carrots, spinach, and supplements containing vitamin A in relation to risk of breast cancer byLongnecker MP, Newcomb PA, Mittendorf R, Greenberg ER, Willett WC(PubMed)
(27) Potential anticancer effect of red spinach (Amaranthus gangeticus) extract by Sani HA, Rahmat A, Ismail M, Rosli R, Endrini S.(PubMed)
(28) The dietary intake of Laminaria, a brown seaweed, and breast cancerprevention by Teas J.(PubMed)
(29) Effect of Japanese seaweed (Laminaria angustata) extracts on the mutagenicity of 7,12-dimethylbenz[a]anthracene, a breast carcinogen, and of 3,2'-dimethyl-4-aminobiphenyl, a colon and breast carcinogen by Reddy BS, Sharma C, Mathews L.(PubMed)
(30) Indoleamine 2,3-dioxygenase activity and L-tryptophan transport in human breast cancer cells.
Travers MT, Gow IF, Barber MC, Thomson J, Shennan DB.(PubMed)
(31) [Substance isolated from the kelp rhizoid identified as L-tryptophan shows high inhibition of breast cancer].[Article in Japanese] by Takahashi N, Ojika M, Dogasaki C, Nishizawa M, Fukuoka H, Sahara H, Sato N, Mori M, Kikuchi K.(PubMed)
(32) Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway by Thoennissen NH, O'Kelly J, Lu D, Iwanski GB, La DT, Abbassi S, Leiter A, Karlan B, Mehta R, Koeffler HP.(PubMed)
(33) Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway by Chou CC, Wu YC, Wang YF, Chou MJ, Kuo SJ, Chen DR.(PubMed)
(34) Apoptosis induction by dohevanil, a DHA substitutive analog of capsaicin, in MCF-7 cells by Tuoya, Baba N, Shimoishi Y, Murata Y, Tada M, Koseki M, Takahata K.(PubMed)
(35) Fruit and vegetable intake in relation to risk of breast cancer in the Black Women's Health Study. by Boggs DA, Palmer JR, Wise LA, Spiegelman D, Stampfer MJ, Adams-Campbell LL, Rosenberg L.(PubMed)
(36) The antioxidant and anticancer effects of wild carrot oil extract by Shebaby WN, El-Sibai M, Smith KB, Karam MC, Mroueh M, Daher CF.(PubMed)

Herbal therapy: Green Tea In Alleviated Symptoms, Risk, Progression and Treatment of Polymyalgia Arthritis (Rheumatica)

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced symptoms,  risk, progression and treatment of  polymyalgia arthritis (rheumatica), some scientists suggested.

Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and Western world.

Polymyalgia rheumatica is an inflammatory disease with muscle pain and stiffness, especially in the shoulders, affecting mostly older adults beyond age of 65.

In animal study of inflammatory diseases induced by injection of LPS, application of green tea bioactive polyphenols EGCG improved antioxidant status of the host and decreased production of inflammatory factors, including PMR through its antioxidant properties.

Further analysis suggested that application of EGCG reduced symptoms of inflammation such as pain, tension, stiffness, swelling of the infectious site without affecting the function of immune system in protection against micro organisms invasion through inhibiting over-expression of tumor necrosis alpha(TNF-α) involved in systematic inflammatory response to acute phase of infection.

The bioactive compound also inhibited reactive oxygen species (ROS) in stimulated production of inflammatory cytokines through free radicals chain reactions in facilitated inflammation and precipitated skeletal muscle dysfunction and degradation by infiltrating immune cells to induce direct injury to muscle tissue or activating catabolic signaling.

In fact, over production of ROS increased continuously expression of mitochondria, NAD(P)H oxidases, xanthine oxidoreductases, and nitric oxide synthases caused imbalance of the free radicals and antioxidant ratio, in orchestrated oxidative stress to muscle cells..

Further evaluation suggested that green tea EGCG reduced expression of interleukin 6 (IL-6), with function in response to infections and tissue injuries.

Long term over production of IL 6 due to the duo factors as a pro and anti inflammatory protein may increase high-level concentrations of serum amyloid A (SAA), which has been found to induce serious complication of several chronic inflammatory diseases through generated and deposited amyloid A amyloidosis into the extracellular space in an abnormal, insoluble, fibrillar form,

Moreover, EGCG also attenuated levels of nuclear factor kappa B (NF-κB) in regulated innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses through activation of tumor necrosis factor alpha (TNF-α) in promoted muscle wasting, leading to muscle atrophy in induction of pain and stiffness and swelling.

Importantly, application of green tea EGCG enhanced the natural antioxidant enzymes in the host such as glutathione, an antioxidant enzyme produced naturally found in every cell and tissue of the body.

These actions together with antioxidant initiated by injection of green tea EGCG stimulated cell regeneration, preserved the muscle cells and tissues and prevented muscle tension to precipitate polymyalgia arthritis.

Deficiency of glutathione levels was found to associate to the early development of Polymyalgia Arthritis in facilitated symptoms of pain, stiffness, achiness, fatigue and fever.

Differentiation of the above was supported by conventional medicine corticosteroids, a powerful anti-inflammatory drugs with function to target pro inflammation cytokines in relieved stiffness and pain in patients with polymyalgia arthritis.

Taken together, Green tea and its bioactive polyphenols EGCG may ne considered as a function food for alleviating symptoms, risk, progression and treatment of polymyalgia arthritis (rheumatica). However, ingestion green tea supplements should be taken with extreme care as acute liver toxicity has been reported in several medical literature.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Epigallocatechin-3-gallate attenuates lipopolysaccharide-induced mastitis in rats via suppressing MAPK mediated inflammatory responses and oxidative stress by Chen J1, Xu J1, Li J1, Du L1, Chen T2, Liu P1, Peng S1, Wang M1, Song H3.(PubMed)
(2) [Anti-inflammatory effects of tea-flavonoids].[Article in German] by Hoensch H1, Oertel R.(PubMed)
(3) Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected]. by Singh R1, Akhtar N, Haqqi TM.(PubMed)

Top 4 Studied Proof Fruits for Reducing Symptoms, Risk, Progression and Treatment of Benign Prostatic Hyperplasia(BPH)

Kyle J. Norton

Benign prostatic hyperplasia(BPH) is a condition characterized by increased number of cells of prostate gland, causing partial, or sometimes virtually complete obstruction of the urinary tract.

According to statistic, BPH commonly starts at age of 30 and symptoms usually can not be realized until age of 50.

More than half of men between age of 60-70 are experience some symptoms of BPH and only 10% are required treatment.

Suggestion of BPH is associated to nutritional status and eating habits.

According to the study, 30 male patients with clinically confirmed and treated disease of the prostatic gland, including 15 men (aged 51-75 years) with BPH and 15 men (aged 51-73 years) with PC, improper nutritional status induced incorrect nutritional habits, may be the cause of the development of some diet-dependent diseases, such as BPH and prostate cancer(a).

A proper diet with vegetable, fruit containing zinc may reduce the risk of the disease from initiation(b)(c).

Epidemiological studies strongly suggested that intake of vegetables and fruits accompanied with healthy life style are associated in reduced risk and treatment of enlarged prostate(d)(e)(f),through enhancing antioxidants activity in inhibited over production of prostate cells(g)(h).

4 Fruits for reducing risk of Benign prostatic hyperplasia(BPH)
1. Orange
Orange is a species of Citrus Sinensis, belongings to the family Rutaceae and native to the Southeast Asia.

According to study, the extract of red orange juice (ROE) inhibited proliferation of fibroblast and epithelial prostate cells in patients with benign prostatic hyperplasia(22).

2. Water melon and strawberry
Lycopene, a member of the carotenoid family, found abundantly in Water melon, strawberry, exerted significant antioxidants effect against formation of prostate disease(23).

In he study of Profluss® included serenoa repens+Selenium+Lycopene on prostatic chronic inflammation (PCI) in 168 subjects, the compositions exhibited anti-inflammatory activity for treatment of PCI in BPH and/or PIN/ASAP patients(24).

In jection of Serenoa repens, lycopene and selenium were superior than Serenoa repens alone in reducing benign prostatic hyperplasia, through reduction of prostate weight, hyperplasia, cell proliferation and growth factor in augmentation of apoptosis(25) in compared to other treatment groups.

3. Cranberry
Cranberry is a species of Vaccinium oxycoccos, belongings to the family Ericaceae.

In the study to evaluate the efficacy and tolerability of cranberry (Vaccinium macrocarpon) powder in men at risk of prostate disease with lower urinary tract symptoms (LUTS) researchers suggested that the application displays a positive effect in lower total PSA level on day 180 of the study(26) and reduced urinary tract symptoms of benign prostatic hyperplasia(27).

Further more cranberry also found to reduce symptoms of dysuria, nocturia, urinary frequency and urgency) in a group pf 270 of BPH patients(28).

Taken together, the evidences finding postulated that adding some portions of orange, water melon, strawberry and cranberry may have a potential effect in reduced symptoms,  risk, progression and treatment of benign prostatic hyperplasia(BPH).

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN


Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
References
(a) Nutritional status and nutritional habits of men with benign prostatic hyperplasia or prostate cancer - preliminary investigation by Goluch-Koniuszy Z, Rygielska M, Nowacka I.(PubMed)
(b) Diet and benign prostatic hyperplasia: a study in Greece by Lagiou P1, Wuu J, Trichopoulou A, Hsieh CC, Adami HO, Trichopoulos D.(PubMed)
(c) Associations of obesity, physical activity and diet with benign prostatic hyperplasia and lower urinary tract symptoms by Raheem OA1, Parsons JK.(PubMed)
(d) Nutrition and benign prostatic hyperplasia by Espinosa G.(PubMed)
(e) Dietary patterns and prostatic diseases by Sebastiano C1, Vincenzo F, Tommaso C, Giuseppe S, Marco R, Ivana C, Giorgio R, Massimo M, Giuseppe M.(PubMed)
(f) Fruit and vegetable consumption, intake of micronutrients, and benign prostatic hyperplasia in US men by Rohrmann S1, Giovannucci E, Willett WC, Platz EA.(PubMed)
(22) Effect of a standardized extract of red orange juice on proliferation of human prostate cells in vitro by Vitali F1, Pennisi C, Tomaino A, Bonina F, De Pasquale A, Saija A, Tita B.(PubMed)
(23) Lycopene for the prevention and treatment of prostate disease by Ilic D.(PubMed)
(24) Effects of Serenoa repens, selenium and lycopene (Profluss®) on chronic inflammation associated with benign prostatic hyperplasia: results of "FLOG" (Flogosis and Profluss in Prostatic and Genital Disease), a multicentre Italian study by Morgia G1, Cimino S, Favilla V, Russo GI, Squadrito F, Mucciardi G, Masieri L, Minutoli L, Grosso G, Castelli T.(PubMed)
(25) [The association of Serenoa repens, lycopene and selenium is superior to Serenoa repens alone in reducing benign prostatic hyperplasia].[Article in Italian] by Squadrito F1, Morgia G.(PubMed)
(26) The effectiveness of dried cranberries ( Vaccinium macrocarpon) in men with lower urinary tract symptoms by Vidlar A1, Vostalova J, Ulrichova J, Student V, Stejskal D, Reichenbach R, Vrbkova J, Ruzicka F, Simanek V.(PubMed)
(27) Risk factors for lower urinary tract symptoms suggestive of benign prostatic hyperplasia in a community based population of healthy aging men: the Krimpen Study by Kok ET1, Schouten BW, Bohnen AM, Groeneveld FP, Thomas S, Bosch JL.(PubMed)
(28) Enteric-coated, highly standardized cranberry extract reduces risk of UTIs and urinary symptoms during radiotherapy for prostate carcinoma by Bonetta A1, Di Pierro F.(PubMed)

The Science Base of Herbs in Induced Weight Loss and Weight Maintenance

By Kyle J. Norton

Overweight and obesity have reached epidemic proportions in many countries, causing economic burden in increased absentees in the workplaces and funding for health care system in dealing with obesity-related disorders such as diabetes, hypertension, and cardiovascular diseases(1).

One of six Malaysian are either extreme overweight or obese, according to Datin Paduka Santha Kumari, chairman of the Selangor branch of the Malaysian Diabetes Association and the global health observatory, at least 2.8 million people die each year as a result of being overweight or obese, and an estimated 35.8 million (2.3%) of dalys global burden of disease are caused by overweight or obesity(2).

Epidemiological studies, linking herbal medicine, foods and vitamins in preventing and treating these diseases have been inconclusive(a)

Some researchers suggested that intake of certain herbal medicine may enhance appetite suppression.

According to the Georgetown University Medical Center, appetite of average daily food intake was decreased only with the herbal formulation, regardless numbers of single ingredient  in comparison of the effectiveness among herbal formulation and a commonly available(3).

Other researchers insisted that using herbs and supplements to induce weight loss should be taken with care, as a considerable number of reports have been published on hepatotosicity associated to intake of  herbal products(4)(5)(6)(7).

The College of Medicine, The Ohio State University insisted that various dietary, lifestyle, and psychological factors are involved in the etiology of Prameha, in initiated disturbances of fat and carbohydrate metabolism in over weight and obese(8), without effective management, obtaining a workable weight loss plan may be extremely difficult.


1. Ginseng
Ginseng is a slow-growing perennial plants with fleshy roots, the genus Panax, belongings to the family Araliaceae. Depending to the climate where it grows, ginseng can be classified mainly into Panax ginseng Asian ginseng (root), Red ginseng, wild ginseng, American ginseng (root)(14).

In 10 obese middle-aged Korean women who took Panax ginseng extracts for 8 wk, showed effectively in influence on gut microbiota in promoting weigh loss but depending to the composition of gut microbiota prior to ginseng intake(15).

In mice fed with high-fat diet, ginseng saponin and ginsenosides exerted anti-obesity effects via the modulation of physiological lipid metabolism in vivo or intracellular signalling in cell culture systems and abnormal physiology of leptin, insulin, and adiponectin  in energy and lipid metabolism(16).

2. Zingiber Officinale(Ginger
Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil, used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.(17).

According to the Tehran University of Medical Sciences, Slimax (extract of several plants including Zingiber officinale and Bofutsushosan) showed a significant decrease in body weight or inhibited weight gain(18).

Application of composition of multi-ingredients supplement containing primarily raspberry ketone, caffeine, capsaicin, garlic, ginger and Citrus aurantium, also improved body composition, waist and hip girth, in an eight-week diet and exercise weight loss program(19).

In a comparison of the weight loss effect of Orlistat, a pharmacological agent promoting weight loss, injection of ginger (Zingiber officinale Roscoe, Zingiberacae) in male albino rats induced a great ability to reduce body weight without inhibiting pancreatic lipase level, or affected bilirubin concentration, and increased peroxisomal catalase level and HDL-cholesterol(20).

3. Cissus quadrangularis (CQ)
Cissus quadrangularis is an ancient herb used to treat a variety of indications, belongings to the grape family, probably native to India or Sri Lanka.

In a randomized, double-blind, placebo-controlled design study involving 123 overweight and obese persons (47.2% male; 52.8% female; ages 19-50). conducted by University of Yaoundé I, Cissus quadrangularis, application of cissus quadrangularis displayed a statistically significant net reductions in weight and central obesity, as well as normalized metabolic syndrome(21).

In comparison of the efficacy of Cissus quadrangularis-only and Cissusquadrangularis/Irvingia gabonensis combination, on weight loss in overweight and obese human subjects, cissus quadrangularis-only group showed significant reductions on all variables in compared to the placebo group, but lower effects in compared to the cissus quadrangularis/Irvingia gabonensis combination group(22)

Intake of CQR-300, a proprietary extract of Cissusquadrangularis, also demonstrated a significant deceased weight and blood glucose levels, serum lipids, thus improving cardiovascular risk factors, according to the University of Yaoundé I,(23).

4. Sambucus nigra
Elder also known as Common Elder, is a shrub or small tree of the genus Sambucus of 30 specie, belongings to the family Adoxaceae, native to the temperate-to-subtropical regions of both the Northern Hemisphere and the Southern Hemisphere, used in traditional and herbal medicine to treat constipation, colic, diarrhea, colds, flu, bronchial and upper-respiratory, irritation of the skin, rheumatism, etc.

The composition of supplement with Sambucus nigra and Asparagus officinalis study, expressed an effectiveness in reduced weight, blood pressure, enhanced physical and emotional well-being and  quality of life(24).

The Tehran University of Medical Sciences, Sambucus nigra study, also demonstrated a significant decrease in body weight in numbers of animal studies(25).

5. Asparagus officinalis
Asparagus is a flowering plant belongings to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa and western Asia,  used from early times as a vegetable and medicine, because of its delicate flavour and diuretic properties(26).

Asparagus officinalis L. powder tablets provided 19 mg saponins per day in overweight and obese subjects reduced mean weight, blood pressure, and enhanced physical and emotional well-being and the quality of life with the rate of very good or good in most of the completers(27).

 In 12 weeks supplementation of a botanical extract-based weight loss formula, including Asparagus, researchers at the Poznan University of Medical Science, indicated that the formula exerts a significantly change of the body composition improvement index (BCI), inducesgreater weight loss than placebo, probably through a concurrently performed exercise program recommended strategy for life style modification(28).

6. Slimax
Slimax (extract of several plants including officinale and Bofutsushosan), in the reviews of the data base of studies published, researchers showed that intake of Slimax indices a significant decrease in body weight(29).

In 41 animal studies, the formula was found to be effective in significant induced weight loss or inhibited of weight gain(29).

Taken altogether, the above herbs may be effectiveness in enhanced weight loss through suppression of appetite and improvement of syndrome induced by over weight and obesity. However, intake of herbal supplement and composition should only be prescribed by herbal doctors.

FDA banned Ephera (Ma Huang) weight loss products in 2004
[Ma Huang is also known as ephedra. The acrid, slightly bitter and warm herb has been used in TCM to promote urination and sweating, and rid of cold, sooth wheezing asthma, ...., by enhancing the functions of lung and bladder channels(9).

According to the Dongguk University, certain chemicals found in Ephera showed an association with changes of BW and BMI through alteration of gut microbiota varied by indigenous microbiota of tested subject(10).

The combined study of a low-calorie diet and Ephera, in 125 otherwise healthy obese women, showed effectively in reducing BMI. RMR change not compensated for by the herbal medicines tried.

Resting metabolic rate (RMR) change seemed to be affected by constitution and body composition rather than by medicine(11). The Dongeui University study of composition GGEx18( Laminaria japonica, Rheum palmatum, and Ephedra sinica) in high fat diet-induced obese mice suggested that GGEx18 improves obesity through skeletal muscle AMPK and AMPK-stimulated expression of PPARα and its target enzymes for fatty acid oxidation, through inhibited lipid accumulation, and similar activation of genes(12).

Please note that due to its adverse reactions of palpitations, stress, headache and insomnia and stroke, heart attacks, cardiac arrhythmias, seizures and psychotic effect, the FDA banned the product on 2004, the Dutch Inspectorate for Health Care and the Ministry of Health in Canada have recently requested a market recall of some ephedrine-containing herbal products in response to above adverse reactions. In the Netherlands, the status of Ephedra-containing products is currently reconsidered(13)]

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography

Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
References
(1) Rising Burden of Obesity in Asia by Ambady Ramachandran and Chamukuttan Snehalatha(Journey of Obesity)
(2) Obesity - Situation and trends(WHO)
(3) Influence of a combination of herbs on appetite suppression and weight loss in rats by Talpur NA1, Echard BW, Manohar V, Preuss HG.(PubMed)
(4) [Hepatotoxicity induced by herbs and medicines used to induce weight loss].[Article in Spanish]by Herrera S1, Bruguera M.(PubMed)
(5) A case report of adult lead toxicity following use of Ayurvedic herbal medication by Breeher L1, Gerr F, Fuortes L.(PubMed)
(6) [Chronic lead intoxication associated with Ayurvedic medication].[Article in Dutch] by Kanen BL1, Perenboom RM.(PubMed)
(7) Potential toxicity of caffeine when used as a dietary supplement for weight loss by Pendleton M1, Brown S, Thomas C, Odle B.(PubMed)
(8) Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: a randomized controlled trial by Hackman RM1, Havel PJ, Schwartz HJ, Rutledge JC, Watnik MR, Noceti EM, Stohs SJ, Stern JS, Keen CL.(PubMed)
(9) Ma Huang(Popular Chinese herbs)
(10) Prameha in Ayurveda: correlation with obesity, metabolic syndrome, and diabetes mellitus. Part 2--management of Prameha by Sharma H1, Chandola HM.(PubMed)
(11) Effect of herbal Ephedra sinica and Evodia rutaecarpa on body composition and resting metabolic rate: a randomized, double-blind clinical trial in Korean premenopausal women by Kim HJ1, Park JM, Kim JA, Ko BP(PubMed)
(12) The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica reduces obesity via skeletal muscle AMPK and PPARα by Shin SS1, Park D, Lee HY, Hong Y, Choi J, Oh J, Lee H, Lee HR, Kim MR, Shen ZB, Cui HH, Yoon M.(PubMed)
(13) [Ephedrine and ephedra in weight loss products and other preparations].[Article in Dutch] by van der Hooft CS1, Stricker BH.(PubMed)
(14) Ginseng, Asian (Panax ginseng) and Ginseng, North America(Popular Chinese Herbs)
(15) Influence of Panax ginseng on obesity and gut microbiota in obese middle-aged Korean women by Song MY1, Kim BS2, Kim H(PubMed)
(16) Lipid metabolic effect of Korean red ginseng extract in mice fed on a high-fat diet by Song YB1, An YR, Kim SJ, Park HW, Jung JW, Kyung JS, Hwang SY, Kim YS.(PubMed)
(17) Popular #Herbs - #Ginger (Zingiber officinale)(Popular Chinese herbs)
(18) A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity by Hasani-Ranjbar S1, Nayebi N, Larijani B, Abdollahi M.(PubMed)
(19) Eight weeks of supplementation with a multi-ingredient weight lossproduct enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women by Lopez HL1, Ziegenfuss TN, Hofheins JE, Habowski SM, Arent SM, Weir JP, Ferrando AA.(PubMed)
(20) Comparative evaluation of the efficacy of ginger and orlistat on obesity management, pancreatic lipase and liver peroxisomal catalase enzyme in male albino rats by Mahmoud RH1, Elnour WA.(PubMed)
(21) The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome by Oben J1, Kuate D, Agbor G, Momo C, Talla X.(PubMed)
(22) The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. by Oben JE1, Ngondi JL, Momo CN, Agbor GA, Sobgui CS.(PubMed)
(23) The effect of Cissus quadrangularis (CQR-300) and a Cissusformulation (CORE) on obesity and obesity-induced oxidative stress by Oben JE1, Enyegue DM, Fomekong GI, Soukontoua YB, Agbor GA.(PubMed)
(24) An observational study and quantification of the actives in a supplement with Sambucus nigra and Asparagus officinalis used for weight reduction by Chrubasik C1, Maier T, Dawid C, Torda T, Schieber A, Hofmann T, Chrubasik S.(PubMed)
(25) A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity by Hasani-Ranjbar S1, Nayebi N, Larijani B, Abdollahi M(PubMed)
(26) #Healthy #Foods - Vegetables - Asparagus (Asparagus officinalis)(health tips for better living and living health)
(27) An observational study and quantification of the actives in a supplement with Sambucus nigra and Asparagus officinalis used for weight reduction by Chrubasik C1, Maier T, Dawid C, Torda T, Schieber A, Hofmann T, Chrubasik S.(PubMed)
(28) Efficacy of 12 weeks supplementation of a botanical extract-based weight loss formula on body weight, body composition and blood chemistry in healthy, overweight subjects--a randomised double-blind placebo-controlled clinical trial by Opala T1, Rzymski P, Pischel I, Wilczak M, Wozniak J.(PubMed)
(29) A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity by Hasani-Ranjbar S1, Nayebi N, Larijani B, Abdollahi M.(PubMed)