Herbal Therapy: Green Tea (-)-Epigallocatechin-3-gallate (EGCG) in Attenuated Risk and Treatment of Gastric Cancer

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Green tea with plenty bioactive phytochemicals may have a direct impact in reduced risk and treatment of gastric cancer, some researchers suggested.

Gastric cancer is a medical condition characterized by uncontrollably growth of cells in the gastric tissues. At the late stage, the cancerous cells may infect other organs and tissue a distance away from the original site

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

According to medical literature published online, in vascular endothelial growth factor (VEGF) over expression in formation of new blood vessel to provide nutrients and fluids for the survival of gastric cancer, application of green tea (-)-Epigallocatechin-3-gallate (EGCG) restricted  the pro-inflammatory cytokine interleukin-6 (IL-6) induced VEGF in stimulated signal protein in transmitted alternated DNA transcript and activated suppression of anti cell apoptosis transcription 3 (Stat3).

Oral administration of green tea extract decreased levels of IL-6, VEGF overexpression in doses depending manner.

In compared to healthy individual, IL-6, VEGF expression were found to increase more than 2.4-fold  in patients with gastric cancer. 

In fact, the chemical compound exhibited anti cancer progressive activity by blocking the process of complex sequence of VEGF expression in transferring faulty DNA transcription to signal proliferation of cancer cells through mRNA in protein synthesis.

In other words, green tea inhibited the progression of cancer development induced by over expression of vascular endothelial growth factor (VEGF) was total depended EGCG's DNA biding activity and inhibition of Stat proteins in differentiated cytoplasm into the nucleus, the important step in initiation of cancer progression.

Further analysis, according to experiments in vitro and vitro, EGCG also expressed a significant effect in the reduced the IL-6 properties in stimulated vascular endothelial cells in promoted cancer cells proliferation and formation.

After taking into account of other con founders, Dr.  Zhu BH, the lead author said, "EGCG inhibits IL-6-induced VEGF expression and angiogenesis via suppressing Stat3 activity in gastric cancer, which has provided a novel mechanistic insight into the anti-angiogenic activity of EGCG".

Additionally, researchers in further illustration of the effect of EGCG (0, 5, 10, 25 or 50 μmol/L), in human gastric cancer cells (AGS) caused by IL-6 (50 μg/L)  suggested that interleukin 6 (IL-6)over expression not only significantly increased VEGF expression in AGS gastric cancer cells, but also increased function of mRNA expression by more than 2.4 in the process to initiated tumor development, in dose depending manner.

Truly, treatment of bioactive EGCG with  doses of 0, 5, 10, 25 or 50 μmol/L demonstrated a therapeutic activities in reduced the release protein of  VEGF to stimulated and mRNA expression of alternated transcript.

In compared to AG490, a Stat3 pathway inhibitor used for treatment of gastric cancer, green tea EGCG blocked the sequence of transcript transferred step in induced expression of pSTAT3 in proliferation of cells and tumor tissues without causing change in STAT3 gene.

In 5-FU resistance of GC SGC7901/FU and MGC803/FU, gastric cancer cell lines, injection of epigallocatechin gallate (EGCG) displayed a significantly suppressed the proliferation and tumor growth through reversed the 5-FU resistance of GC cells thorough inhibited the P-glycoprotein 1  (MDR1) and P-glycoprotein (P-gp) also also known as multidrug resistance proteins in transmitted transcript in obstructing cell internalization of chemotherapeutic agents and developing transporter mediated resistance by cancer cells during anti-tumor treatments.

Taking altogether, green tea bioactive (-)-Epigallocatechin-3-gallate (EGCG) may be considered as a potential agent in reduced risk of angiogenesis and a secondary and adjunct treatment in combined with standard chemotherapy in treatment of gastric cancers.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) (-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer by Zhu BH1, Chen HY, Zhan WH, Wang CY, Cai SR, Wang Z, Zhang CH, He YL.(PubMed)
(2) [(-)-Epigallocatechin-3-gallate reduces vascular endothelial growth factor expression in gastric cancer cells via suppressing activity].[Article in Chinese] by Zhu BH1, He YL, Zhan WH, Cai SR, Wang Z, Zhang CH, Chen HY.(PubMed)
(3) Reversal of 5-fluorouracil resistance by EGCG is mediate by inactivation of TFAP2A/VEGF signaling pathway and down-regulation of MDR-1 and P-gp expression in gastric cancer by Tang H1,2, Zeng L2, Wang J2, Zhang X2, Ruan Q2, Wang J2, Cui S2, Yang D1.(PubMed)

Alternative Therapy: Yoga in Reduced Risk and Complications of Preeclampsia in High Risk Pregnancy

Kyle J. Norton

Yoga participated may have a profound and strong implication in reduced risk of of complications and improvement of pregnancy outcome in high risk pregnancy, some studies suggested

Preeclampsia is a medical condition characterized with abnormal high blood pressure during pregnancy which is one major risk factor in interference with pregnancy outcome, negatively.

Yoga, the ancient technique practice for harmonized external and internal body well being, through breath control, meditation, bodily movement and gesture..... has been well known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

According to study of 68 high-risk pregnant women recruited from two maternity hospitals in Bengaluru, India randomly assigned into yoga and control groups with yoga group (n=30) received standard care plus one-hour yoga sessions, three times a week, from the 12th to the 28th week of gestation and the control group (n=38) received standard care plus conventional antenatal exercises (walking) during the same period, women in yoga + standard care showed a significant fewer pregnancy induced hypertension (PIH)

The risk of pre-eclampsia on yoga group showed a ratio of 0,042 in compared to control.

Furthermore, high risk pregnancy women participated maternal yoga also expressed a significant lower syndromes of preeclampsia, ...... and improved pregnancy outcome.

In support to the above differentiation, the study of 121 women attending antenatal clinic at Gunasheela Surgical and Maternity Hospital (GSMH) in Bangalore, India, with abnormal Doppler study of umbilical and uterine arteries and between 18-20 weeks of pregnancy. Out of 121 participants, 68 women randomly assigned to the yoga group and 53 women to control group, after taking into account of other confounders, researchers suggested that women practiced physical postures, breathing and meditation showed a strong improvement in occurrence of complications of pregnancy, including hypertension.

Further analysis also indicated that yoga score a higher outcome in all aspects including high risk pregnancy-induced intrauterine growth retardation, pre-term delivery, particularly hypertension, in compared to non yoga group.

Indeed, maternal and regular yoga exercise improved outcome of high risk pregnancy was attributed to the function in ameliorated metabolic syndrome risk, that has been found to associate to the development of pre-eclampsia risk and exaggerated pre-eclampsia complications through enhancing production of antioxidant in inhibited reactive oxygen species in initiated oxidative stress which can cause cellular dysfunction.

Additionally, yoga also has an implication in improved cellular immunomodating activity, thus reducing risk of auto immune diseases caused by over expression pro inflammatory cytokins which play an important role in control of cell growth, cell proliferation, cell differentiation and apoptosis.

More interestingly, in the study of group of women to investigate the correlation of high risk of complication of impaired placentation and inadequate trophoblast invasion in first trimester uterine artery resistance, by randomly assigned 59 high-risk pregnant women into yoga (n = 27) and control (n = 32) groups, scientists showed that yoga group showed significantly higher values in the (28th week) for biparietal diameter, head circumference, femur length, and estimated fetal weight measured by  RM-ANOVA assay in compared to control.

Repeated Measures (RM)ANOVA is a technique used to test the equality of means in comparison three or more groups, with the same numbers of participants.

Additionally, researchers also indicated that women in yoga group demonstrated a strong improvement of the resistance index in the right uterine artery, umbilical artery, and fetal middle cerebral artery and lower impedance.

In fact, the improved blood circulation, strengthen fetus artery and prevented initiated pre-eclampsia and pre-eclampsia complications of regular yoga practice showed a significantly reduced risk of impaired placentation and cytotrophoblastic stem cell differentiation into extravillous cytotrophoblasts (EVCT) with invasive properties.

According to statistic 7% of  impaired placentation and inadequate trophoblast invasion in first trimester uterine artery resistance were associated to condition of pre-eclampsia and pre-eclampsia complications in high risk pregnancy women.

Taking altogether, there is no doubt that yoga may be considered as adjunct therapy used combined with standard treatment in attenuated risk of complications and improved favorable pregnancy outcome in high risk pregnancy women.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The effects of yoga in prevention of pregnancy complications in high-risk pregnancies: a randomized controlled trial by Rakhshani A1, Nagarathna R, Mhaskar R, Mhaskar A, Thomas A, Gunasheela S.(PubMed)
(2) Efficacy of yoga in pregnant women with abnormal Doppler study of umbilical and uterine arteries by Narendran S1, Nagarathna R, Gunasheela S, Nagendra HR.(PubMed)
(3) Efficacy of yoga on pregnancy outcome by Narendran S1, Nagarathna R, Narendran V, Gunasheela S, Nagendra HR.(PubMed)
(4) Oxidative stress and metabolic syndrome by Roberts CK1, Sindhu KK.(PubMed)
(5) Regular Yoga Practice Improves Antioxidant Status, Immune Function, and Stress Hormone Releases in Young Healthy People: A Randomized, Double-Blind, Controlled Pilot Study by Lim SA1, Cheong KJ1.(PubMed)

Food Therapy: Beet or Beet Root, the Function Food in Prevention and Treatment of Prostate Cancer

Kyle J. Norton


Prostate Cancer is a medical condition characterized by irregular cell growth and multiplied disorderly in the prostate tissues.

Beet, best known as the beetroot or garden beet, belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.

Red beetroot (Beta vulgaris L.) may have a profound effect in reduced risk and treatment of prostate cancer, some studies suggested.

According to the Howard University, red beetroot (Beta vulgaris L.) extract (B), approved by Food and Drug Administration and European Union, in drinking water may be safe and used as cancer chemopreventive effect in humans.

Intake of the extract showed a significant effect in reduced synergistic antiproliferative activity against prostate (PC-3) tumor cells of human origin.

When combined anticancer drug doxorubicin (D), the combination acted synergistically in expression of cytotoxicity against prostate cancer at ratio of 1:5.

In a total of 24 patients (mean age 68+/-8 years) with hormone-resistant and metastatic prostate cancer treated with taxan chemotherapy, given twice 10 g daily for 1 month of natural table beet product come from commercial service, intake of beet juice showed a sgnificant effect in control of the progression of prostate cancer in promoted life expectancy and reduced toxicity side effect induced by conventional chemo-drug.

The efficacy may be contributed by the mediated activities of phytochemicals in the juice in inhibition of inflammatory through expression of production of antioxidants.

The study also suggested that moderate and permanent consumption of table beet products may favorably affect the life expectancy of prostate cancer patients.

Furthermore, in the testing extract of red beetroot (Beta vulgaris L.), the FDA approved red food color E162,against vrious caner cell lines, researchers at the Howard University found that the extract showed a significant cytotoxicity in decrease the growth rate of the PC-3 cells, although lesser in compared to doxorubicin, a chemo medicine( (8.6% vs. 100%, respectively, at 29 µg/ml concentration of each, three-day test period).

The study also suggested that betanin, the major betacyanin constituent found in beetroot, may be phytochemicals responsible for the cytotoxicity.

This findings showed that beet root may be used as functional food to reduced risk of early onset and treatment of prostate cancer. And reduced adverse toxicity when used combination with chemo drugs.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines by Kapadia GJ1, Rao GS, Ramachandran C, Iida A, Suzuki N, Tokuda H.(PubMed)
(2) [Effects of bioactive molecules of Beta vulgaris L. ssp. esculenta var. rubra on metastatic prostate cancer].[Article in Hungarian]by Nyirády P1, Sárdi E, Beko G, Szucs M, Horváth A, Székely E, Szentmihályi K, Romics I, Blázovics A.(PubMed)
(3) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H.(PubMed)

Herbal Therapy: Green Tea Epigallocatechin Gallete (EGCG) and Theaflavin (TF) in Ameliorated Risk and Treatment of Liver Cancer

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Green tea may have a sustainable and positive effect in reduced risk and treatment of liver cancer, Some studies suggested

Liver cancer is a medical condition caused by cell growth disorderly and uncontrollably in the liver tissues. At the later stage, the cancerous cells may travel a distance away to infect other healthy organs and tissues.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

In the review of medical literature published online, green tea bioactive phytochemicals such as Epigallocatechin gallate (EGCG) and Theaflavin (TF), in prevention and treatment of liver cancer have been postulated by several mechanisms.

In liver cancer, animal model induced by chronic exposure of N-nitrosodiethylamine (NDEA), a carcinogenic and mutagenic organic compound, application of green tea bioactive compounds Epigallocatechin gallate (EGCG) and Theaflavin (TF) demonstrated a strong effect in reduced initiation of cancer formation and  potential chemopreventive effect in pre and post treatment of the injected animal.

Further observation showed that EGCG/TF action in restrain the over expression of liver cancer also found to modulate similarly to those of CD44-specific cell membrane binding combined with near-infrared irradiation in induction of cellular apoptosis.

High CD44-positive expression is found to associate to acute cancer cells killing.

The restriction processes of EGCG/TF in modification of onset of liver cancer development, was also found to modify multiple biogenesis involved maintaining a relatively stable equilibrium in organs tissues(self-renewal Wnt/β-catenin, Hh/Gli1 pathways) in gene with implication of cell cycle progression, apoptosis and cellular transformation and cell differentiation and proliferation(Cyclin D1, cMyc and EGFR) and tumor suppressor (E-cadherin) during the carcinogenesis processes.

Additional illustration also indicated that the therapeutic efficacy of tea polyphenols epigallocatechin gallete (EGCG) and theaflavin (TF) also regulated the proteins expression of cell differentiation, polarity and proliferation(the self-renewal Wnt and Hedgehog (Hh) pathways).during CCl4/N-nitosodiethylamine-induced mouse liver carcinogenesis.

Application of green tea bioactive tea polyphenols epigallocatechin gallete (EGCG) and theaflavin (TF) induced chemo preventive potential in maintain cell integrity at the 30 weeks of CCl4/N-nitosodiethylamine application.

Continuous administration of EGCG/TF exerted a strong impact in reduced proliferation and increased apoptosis, as well as decreased function of hepatic progenitor cells (HPCs) in participated restoration of the cancerous liver tissue and population with cancer stem cell-like characteristics in liver carcinoma observed by AFP and CD44 expression.in CCl4/N-nitosodiethylamine-induced mouse liver carcinogenesis.

More interestingly, also during the restriction processes of EGCG/TF, the bioactive compounds also modulated the expression of tumor progression to a more invasive phenotype(phospho-β-catenin-Y-654), tumor suppressor(β-catenin), the proliferation, migration and invasion of liver cancer gene(sFRP1 ) and gene in control tumor suppressor(β-catenin).

In other words, green tea EGCG/TF inhibited the contaminated cells inflicted by injection of CCl4/N-nitosodiethylamine to prevent the initiation of liver cancer through modulation of certain gene expressions involved in liver cancer progression.

In short, the inhibition of liver carcinogenesis by EGCG/TF was attributed to reduction in hepatocyte progenitor cell and stem cell population in restored liver cancerous cells damage through various mechanisms indicated above.

Taken together, green tea bioactive ingredients epigallocatechin gallete (EGCG) and theaflavin (TF) may be a useful secondary preventive agents for targeting liver cancer in combination with standard chemotherapies.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice by Sur S1, Pal D2, Roy R2, Barua A2, Roy A3, Saha P2, Panda CK4.(PubMed)
(2) Tea polyphenols epigallocatechin gallete and theaflavin restrict mouse liver carcinogenesis through modulation of self-renewal Wnt and hedgehog pathways by Sur S1, Pal D2, Mandal S3, Roy A4, Panda CK5.(PubMed)

Herbal Therapy: Green Tea (-)-Epigallocatechin-3-O-Gallate (EGCG) For Prevention and Treatment of Melanoma

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Green tea may have a profound and sustainable effect in reduced risk and treatment of melanoma, some scientists suggested.

Melanoma, is a medical condition characterized by irregular cell growth of  pigment-containing cells known as melanocytes. At the later stage, the cancerous cells may travel a distance away to infect other healthy organs and tissues.

According to the study, approximately 7,200 Canadians will be diagnosed with melanoma skin cancer.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

In the review of literature published online, green tea bioactice EGCG significantly inhibited the growth, migration and invasion of melanoma cells through numbers of mechanism.

Gene implications in initiated cancer development and cancerous cells proliferation have gone through extensive research, particularly in melanoma.

In melanoma, green tea biactice EGCG demonstrated a significant effect in knockdown gene over expression (TRAF6) in reduced migration and invasion of melanoma.

TRAF6 is a protein with function in activation of IkappaB kinase (IKK) in response to inflammation.

In fact, green tea biactive EGCG directly bind to TRAF6 in melanoma in attenuated the interaction of
between TRAF6 and UBC13(E2) in activated the protein (IkappaB kinase (IKK)) in production of pro inflammatory cytokins.

The ubiquitin-conjugating enzyme(UBC13(E2)) are essential in activation protein (NF- kappa B) in controls transcription of DNA, cytokine production and cell survival.

Furthermore, the phytochemicals also suppressed the TRAF6 E3 ubiquitin ligase activity of the tumor generated by TRAF6 in regulation of important biological processes, particularly, in cell division and for the survival of the tumors.

Additionally, green tea biactice EGCG also regulated the gene expression of proteins (IκBα and p-TAK1 e) in modulation and inactivated NF-κB-directed gene expression of inflammation, immunity, cell proliferation, differentiation, and survival in melanoma.

Dr. Zhang J, the lead author said, " EGCG is a novel E3 ubiquitin ligase inhibitor that could be used to target TRAF6 for chemotherapy or the prevention of melanoma".

Other researchers in focus of Green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) effect in attenuated and treatment of melanoma in the gene implication via MicroRNAs (miRNAs, non-coding RNAs involved in various biological processes by regulating their target genes) also indicated that

Green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) inhibited melanoma tumor growth by activating 67-kDa laminin receptor (67LR) signaling which has an function in down regulated tumor cell proliferation and tumor formation by inducing apoptosis.

The bioactive compound also up-regulated miRNA-let-7b expression in induced tumor suppressor function in decrease function of 67LR in enhanced invasive and metastatic melanoma cells.

Indeed, green tea EGCG-also displayed a significant effect in promote function of let-7b in altering the traits,of malignant cell in melanoma through regulating the expression of HMGA2.with action as DNA transcriptional regulator.

Green tea EGCG. also induced expression of  let-7b  in inhibitions of oncoproteins and activation of tumor suppressor via tumor-over expressed 67LR in activation of PP2A, a tumor suppressor. through adenylate cyclase/cAMP pathway in cell communication.

In compared the effects of TNF-related apoptosis-inducing ligand (TRAIL), a protein with function in in induced tumor cells apoptosis. and green tea bioactive EGCG for treatment of groups of melanoma.

In A375 melanoma cell line, TRAIL application group demonstrated a strong effect in inhibition with apoptosis rate was 11.8% at dose of 150ng/mL in compared to green tea EGCG treatment group of 5%-7% .

Interestingly, in combined TRAIL and green tea EGCG treatment groups, the inhibited rate increased sufficiently to 48.9 - 59.1%

Further analysis also found that EGCG effective in treatment of melanoma was attributed to activity of caspase-3 rather than caspase-8 in mediation of programmed cell death (apoptosis).

The findings suggest that by blocking the sequence of gene expression of tumor, green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) may be considered as an adjunct combined with TRAIL for prevention and treatment of melanoma.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Epigallocatechin-3-gallate(EGCG) suppresses melanoma cell growth and metastasis by targeting TRAF6 activity by Zhang J1,2, Lei Z1,2, Huang Z3, Zhang X1,2, Zhou Y1,2, Luo Z1,2, Zeng W1,2, Su J1,2, Peng C1,2, Chen X1,2.(PubMed)
(2) EGCG enhances TRAIL-mediated apoptosis in human melanoma A375 cell line by Shen Q1, Tian F, Jiang P, Li Y, Zhang L, Lu J, Li J.(PubMed)
(3) Epigallocatechin-3-O-gallate up-regulates microRNA-let-7b expression by activating 67-kDa laminin receptor signaling in melanoma cells by Yamada S1, Tsukamoto S1, Huang Y1, Makio A1, Kumazoe M1, Yamashita S1, Tachibana H1.(PubMed)

Herbal Therapy: Green Tea polyphenol epigallocatechin-3-gallate (EGCG) in Decreased Progression and Treatment of Her-2/ Positive Breast Cancer

Kyle J. Norton

Green tea may have a strong and positive impact in reduced breast cancer development in women with mutated gene HER2, some scientists suggested.

Breast cancers with HER2 gene amplification or HER2 protein overexpression are called HER2-positive

HER2 is a protein that causes breast cancer cells to grow aggressively.

HER2-positive breast cancers tend to grow faster and are more likely to spread and come back in compared to HER2-negative breast cancers.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Breast cancer is a medical condition characterized by irregular cells growth in the breast tissues. At the late stage, cancerous cell may travel a distance away to infect other organs and tissues from original site.

The study of bioactive green tea polyphenol epigallocatechin-3-gallate (EGCG) was found to decrease progression of breast cancer cells with Her-2/neu over expression, through many mechanisms.

Application of green tea EGCG to Her-2/neu-driven mammary tumor cells showed a significant effect in  blocking over expression of key regulators in the epithelial to mesenchymal transition (EMT) pathway in induced invasive cell proliferation in breast outer layer tissues.

Additionally, the bioactive compound also inhibited Her-2/neu-driven mammary tumor cells by enhanced genes expression in related to tumor suppressor(epithelial genes E-cadherin, gamma-catenin) and promoted tumor cell cycle arrest(MTA3) and involved in the regulation of cellular proliferation and differentiation in target tissues(estrogen receptor alpha (ERalpha)).

Further analysis the study also addressed the important role of green tea EGCG in inhibition of  Her-2/neu-driven mammary tumor cells through decreased the function of snail gene in expression of tumor cells proliferative activity.

In cell migration and invasion assays, green tea EGCG also restrained branching colony growth and invasion of Her-2/neu-driven mammary tumor cells

Interestingly, invasive and metastatic I phenotypes in mouse mammary tumor cells driven by over expression of protein in transmuted transcription of DNA, involved cell survival and a messenger-independent in protect against apoptotic tumor cells also inhibited by administration of green tea EGCG.

Furthermore, green tea EGCG treatment activated FOXO3a in triggered apoptosis of tumor cells and reversed the invasive characteristic of in ERalpha-positive breast cancer cells by blocking expression of protein of transforming growth factor beta in induced tumor cell growth, cell proliferation, cell differentiation.

Further differentiation of over expression of the epidermal growth factor receptor family member Her-2/neu in breast cancer, application of EGCG not only inhibited mouse mammary tumor virus (MMTV)-Her-2/neu NF639 cell growth in culture and soft agar.but also ameliorated risk of basal Her-2/neu receptor tyrosine phosphorylation in contribution of exceptional oncogenic potency. via regulation of enzymes involved in cellular growth, proliferation, differentiation (phosphatidylinositol 3- kinase), and proteins in induced oncogenic transformation (Akt kinase to NF-kappaB pathway).

In SMF derived from mammary gland tumors and cultured and also epidermal growth factor receptor 4,  green tea EGCG inhibited the expression of a significantly higher phosphorylation state of basal receptor which display high constitutive Her-2/neu tumor.

Interestingly in the study of epigallocatechin-3 gallate (EGCG) effects in inhibited growth of Trastuzumab-resistant HER2-driven breast cancer cells, researchers found that  EGCG treatment in a dose-dependent inhibited trastuzumab-resistant BT474 human breast cancer cells, isolated by chronic trastuzumab exposure  and JIMT-1 breast cancer cells, by decreasing tumor growth, tumor cellular ATP production in absorption of chemical energy obtained from the breakdown of food molecules and releases it to fuel other cellular processes, and by inducing tumor cells apoptosis at high concentrations.

Most importantly, EGCG also suppressed multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration. of Akt activity, improved FOXO3a function in triggered apoptosis of tumor cells and elevated expression of anti tumor suppressor proteins. p27Kip1

Dr. Eddy SF , the lead author said, "EGCG in combination with trastuzumab may provide a novel strategy for treatment of HER2-over expressing breast cancers, given that EGCG can cross the blood-brain barrier".

Taking altogether, green tea with abundant bioactive polyphenol epigallocatechin-3-gallate (EGCG) may have therapeutic potential in reduced risk and progression of HER2 positive breast cancer, particularly when combined with other chemo-medicine.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Trastuzumab-resistant HER2-driven breast cancer cells are sensitive to epigallocatechin-3 gallate by Eddy SF1, Kane SE, Sonenshein GE.(PubMed)
(2) Activation of FOXO3a by the green tea polyphenol epigallocatechin-3-gallate induces estrogen receptor alpha expression reversing invasive phenotype of breast cancer cells by Belguise K1, Guo S, Sonenshein GE.(PubMed)
(3) Green tea polyphenol epigallocatechin-3 gallate inhibits Her-2/neu signaling, proliferation, and transformed phenotype of breast cancer cells by Pianetti S1, Guo S, Kavanagh KT, Sonenshein GE.(CANCER RESEARCH 62, 652–655, February 1, 2002])

Herbal Therapy: Green Tea, The Nano-Beverage for Treatment of Ovarian Cancer

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Green tea may have a potential effect in reduced risk and treatment of ovarian cancer, some institute studies suggested

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Ovarian cancer is a medical condition characterized by cell growth disorderly in the ovaries. At the late stage, cancerous cells may infect tissues and organs far away from the originated site.

In the analysis of the EGCG effects on 8 ovarian cancer cell lines (SKOV3, CAOV3, OVCAR3, OVCAR10, A2780, CP70, C30, and C200) and showed IC50s for EGCG at the micromolar range, researchers found that EGCG inhibited all ovarian cancer cell lines in dose depending manner.

Normal dose application of EGCG displayed a significant increase of antioxidant in reduced ROS over expression of oxidative stress in inhibited ovarian cancer through cell cycle arrest in G2/M phase.

Further differentiation also revealed that administration of EGCG at common dose not only demonstrated a 6 fold increase of cisplatin potency for treatment of SKOV3, CAOV3, and C200 cells, but also attenuated the chemodrug toxicity.

However, the effect of EGCG on the formation of reactive oxygen species (ROS) was biphasic.
The phytochemical was shown to induce and decrease ROS formation in different doses.

Therefore, higher dose of EGCG promoted over expression of antioxidants in reduced oxidative stress may amplify the toxicity in ameliorated human cancer cells proliferation and induced apoptosis.

Dr., the lead author said, "EGCG may accentuate oxidative stress to inhibit growth of ovarian cancer cells and sensitize them to cisplatin".

Other researchers in the study of toxicity of EGCG suggested that green tea catechin, (-)-epigallocatechin-3-O-gallate (EGCG) as a potent adjuvant to enhance the anti tumor efficacy of cisplatin while mitigating its harmful side effects through various mechanisms.

Application of EGCG showed to promote hyaluronic acid function in regulation of normal cell division and prevention of the acid in initiation of cancerous cell proliferation.

Hyaluronic acid, a polysaccharide molecule, plays an important role in cell proliferation and migration, and may involve in the progression of some malignant tumors.

Additionally, EGCG also expressed anti cancer effect by promoting the injection of chemo medicine cisplatin into the CD44-over expressing cancer cells to prevent over growth of tumor cells.

In regard to toxicity, EGCG on one hand, reduced over expression of oxidative stress in initiated toxicity against off-target organs and tissues through induction of a significant antioxidant activity on the hand, and stimulated function of toxicity originating from cisplatin into the target tumors on the other..

Further analysis, green tea catechin-based micellar nanocomplexes also inhibited superiorly against tumor growth with no injection of cisplatin and expressed a significant inhibition without induced toxicity in both cancer cells suspended in culture medium and injected into the animal models and peritoneal metastatic model of human ovarian cancer.

In other words, green tea catechin-based micellar nanocomplexes may be considered as a safe and effective cisplatin nanomedicine for ovarian cancer treatment..

More interestingly, in the additionally examined the effect of EGCG in suppressing ovarian cancer cell growth in 3 human ovarian cancer cell lines (p53 negative, SKOV-3 cells; mutant type p53, OVCAR-3 cells; and wild type p53, PA-1 cells),

EGCG decreased tumor growth in each cell line in a dose-dependent fashion and induced apoptosis and cell cycle arrest, particular to the G(1) phase in SKOV-3 and OVCAR-3 cells in compared to G(1)/S transition phase arrest in PA-1 cells.

The chemical also differentiately upregulated the expression of genes and proteins in promoted cancer cell arrest, suppressed tumor growth and induced cell death (Bax, p21, Retinoblastoma, cyclin D1, CDK4, Bcl-X(L)) by more than 2-fold

Taking altogether, green tea may have a profound effect in reduced risk and treatment of ovarian cancer through expression of phytochemical EGCG. However, intake of green tea extract must be taken with care, as overdoses were found to induce liver toxicity.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN



Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Hyaluronic acid-green tea catechin micellar nanocomplexes: Fail-safe cisplatin nanomedicine for the treatment of ovarian cancer without off-target toxicity by Bae KH1, Tan S1, Yamashita A1, Ang WX1, Gao SJ1, Wang S1, Chung JE1, Kurisawa M2.(PubMed)
(2) Epigallocatechin-3-gallate delivers hydrogen peroxide to induce death of ovarian cancer cells and enhances their cisplatin susceptibility by Chan MM1, Soprano KJ, Weinstein K, Fong D.(PubMed)
(3) Anticancer effects of (-)-epigallocatechin-3-gallate on ovarian carcinoma cell lines by Huh SW1, Bae SM, Kim YW, Lee JM, Namkoong SE, Lee IP, Kim SH, Kim CK, Ahn WS.(PubMed)