Herbal Therapy: Chaste tree berry, The Best Antinociceptive Functional Food

Kyle J. Norton



Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite outcomes.

A recent study suggested that essential oil isolated from Chaste tree berry mayhave a potential effect in reduced neuro-pain through antinociceptive function in tested subjects.
Antinociceptive effect is the activity in reduced pain through interference with information transmitted and received of brain neurons.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

In the study of three behavioral models of nociception in adult male Wistar rats conducted by the University of Tabriz, topical essential oil extracted from Vitexagnus-castus (EOVAC) applied on  animal expressed a reduced pain responses in tail immersion tests, inhibited the acetic acid-induced writhing response with little adverse effects.

Dr. Khalilzadeh E, the lead author said, " major components of the EOVAC were α-pinene (14.83%), limonene (10.29%), β-caryophyllene (6.9%), sabinene (5.27%), and β-farnesene (5.9%), (may have direct infleunce to the) endogenous opioidergic system as well as muscarinergic receptors of cholinergic system may be involve in the antinociceptive activity of Vitex agnus-castus essential oil in these models of pain in rats".

Interestingly, the extract of herbal medicine also displayed a strong effect against chronic inflammation in induced pain.

The joint study lead by the Federal University of Santa Maria suggested that crude extract caused antinociceptive/antidepressant-like effects in the CFA-induced chronic inflammation model in comparable to naloxone, without altered inflammatory parametersat doses of 10mg/kg,

This result indicated that The VmE extract demonstrated pain relief through inducing opioid-dependent antinociception and antidepressant-like effects, without anti-inflammatory activity.

Further more, in the investigated petroleum ether fraction (PEF) from the aqueous ethanol extract of Chaste tree berry in several nociceptive mouse models, mouses treated with the fraction produced significant dose-related inhibitions on chemical nociception in comparable to Naloxone (1 mg/kg bw subcutaneously), a non-selected opioid receptor antagonist.

In xylene-induced ear edema test, the fraction also exerted a strong analgesic effects partially mediated by its anti-inflammatory activity.

Taking together, Chaste tree berry may have a therapeutic potential to be used as antinociceptive functional food in reduced pain through blocking the information transfer by neurotransmitters.

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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Antinociceptive effects, acute toxicity and chemical composition of Vitex agnus-castus essential oil by Khalilzadeh E, Vafaei Saiah G, Hasannejad H, Ghaderi A, Ghaderi S, Hamidian G, Mahmoudi R, Eshgi D, Zangisheh M.(PubMed)
(2) Antinociceptive and antidepressant-like effects of the crude extract of Vitexmegapotamica in rats by Hamann FR1, Zago AM2, Rossato MF3, Beck VR4, Mello CF4, de Brum TF5, de Carvalho LM6, Faccin H6, Oliveira SM7, Rubin MA8(PubMed)
(3) Antinociceptive activities of the liposoluble fraction from Vitex negundo seeds by Zheng CJ1, Huang BK, Han T, Zhang QY, Zhang H, Rahman K, Qin LP.(PubMed)

Herbal Therapy: Chaste Tree Berry, The Whole Herb Medicine for Prevention and Treatment of Cataract

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite outcomes.

Recent study suggested that Chaste Tree Berry may be used to modulate risk and treatment of selenite induced cataractogensis.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Cataract is a condition of blur vision caused by clouding of the lens in the eye.

According to the University of Kerala, flavonoids found in the herbal plant exerted cataract protective effect in reduced damage of lenticular membrane and abnormal fiber structure in patient with cataract viewed through electron microscopy.

Furthermore, the study also found that Chaste tree berry also expresses a significant improvement of chaperone property of α-crystallin and soluble protein levels in two dimensional-polyacrylamide gel electrophoresis (2D-PAGE) and immunoblot analysis. 

Dr. Rooban BN, the lead author said, " FVN modulated selenite induced cataractogensis in rat pups by preventing loss of chaperone property, various changes in lens proteins, and lens structure, further strengthening its protective role".

Some researchers suggested that the efficacy of chaste tree berry in reduced risk and treatment of cataract may be a result of phytochemical antioxidants activity in scavenge free radicals cause of the disease, as oxidative stress, loss of calcium homeostasis, calpain activation and protein insolubilization are found to associate to cataract patients.

More importantly, in a study of eight-day-old Sprague-Dawley rat pups divided into four groups: Control (G I), Sodium selenite-induced (G II), Sodium selenite+quercetin treated (G III), Sodium selenite+flavonoids from Vitex negundo (FVN) (G IV), group fed with sodium selenite+flavonoids showed normal levels of expression of lens of water soluble proteins in compared to other groups.

In fact, fed treated with FVN showed to exhibite the antioxidant effects in modulating biochemical parameters against selenite-induced cataract, the University of Kerala insisted.

In support to the above differentiation, the Sprague-Dawley rat pups of 8 days old divided into control (G I), selenite induced (G II), and selenite + V. negundo treated (G III) with cataract induced by the single subcutaneous injection of sodium selenite (4 mg/kg body weight) on the tenth day and V. negundo (2.5 mg/Kg body weight) administered intraperitoneally from eighth to 15th day study, group III showed to exert reduced activities of superoxide dismutase, catalase, lower level of reactive oxygen species, Ca(2+), and thiobarbituric acid reactive substance significantly.

Taking together, Chaste tree berry may process of therapeutic potential used for prevention and treatment of cataract with mild adverse effects.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

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Holistic System In Existence That Will Show You How To
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FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Analysis on the alterations of lens proteins by Vitex negundo in selenite cataract models by Rooban BN1, Sasikala V, Sahasranamam V, Abraham A.(PubMed)
(2) Vitex negundo attenuates calpain activation and cataractogenesis in selenite models by Rooban BN1, Lija Y, Biju PG, Sasikala V, Sahasranamam V, Abraham A.(PubMed)

Herbal Therapy: Andrographis, The Best Anti Platelet Aggregation Herbal Medicine

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

In Herbal medicine, symptoms of the diseases can only be eased gradually, depending to stage of the treatment which directly address to the cause of the disease.


A recent vitro study suggested that Andrographis paniculata exerted the enormous inhibitory effect on platelet aggregation.

Antiplatelet activity is the effect in decreased platelet aggregation and inhibited thrombus formation.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,.....

According to the Mahidol University, diterpenoids isolated from plant, including andrographolide (AP(1)) and 14-deoxy-11,12-didehydroandrographolide (AP(3)) in the thrombin-induced platelet aggregation, significantly inhibited blood clot a concentration-(1-100 microM) but not in higher doses, and time-dependent manner.

The study also suggested that the effective of this action was attributed by the inhibition of the regulation of functions in differentiate cells.

Due to inefficacy in applications of higher concentrations, Dr. said, "the extract with high level of AP(3) (Extract B) (IC(50) values=50-75 microg/ml) showed less inhibitory activity against thrombin than the extract with lower level of AP(3) (Extract A) (IC(50) values=25-50 microg/ml). These results indicate that the standardized A. paniculata extract may contain other antiplatelet compounds rather than AP(1) and AP(3), which contribute to high antiplatelet activity".

In comparison of platelet aggregation effects with non-steroidal antiinflammatory drugs (NSAID), treatment of the herbal medicine showed a strong influence on the biosynthesis of eicosanoids in cell signaling and the platelet-activating factor (PAF) with the ability to cause platelet aggregation, inflammation, and allergic response,...

The study also proposed that the mechanism of these actions  may be associated with the cardiovascular and antithrombotic activity in compared to that of non-steroidal antiinflammatory drugs (NSAID),

Other study insisted that the effects of andrographolide in platelet activation may be a result of reducing the mortality of ADP-induced acute pulmonary thromboembolism and significantly prolonged platelet clumping formation of which decrease the platelet aggregation activity.

Taking together, there is no doubt that herbal Andrographis processes an anti  Platelet Aggregation through exhibiting the functions of various mechanisms. People with bleeding disorder should only take the herbal medicine with permission of related field specialist.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Inhibitory effect of Andrographis paniculata extract and its active diterpenoids on platelet aggregation by Thisoda P1, Rangkadilok N, Pholphana N, Worasuttayangkurn L, Ruchirawat S, Satayavivad J.(PubMed)
(2) Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation by Amroyan E1, Gabrielian E, Panossian A, Wikman G, Wagner H.(PubMed)
(3) A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of plateletactivation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP by Lu WJ1, Lee JJ, Chou DS, Jayakumar T, Fong TH, Hsiao G, Sheu JR.(PubMed)

Herbal Therapy: Chaste Tree Berry (Seeds), The Best in Relieved Symptoms and Treatment of Arthritis

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite outcomes.
A renowned institute study suggested that seeds of Vitex negundo L. (Verbenaceae) may have potential effects for the treatment of rheumatism and joint inflammation.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Arthritis, a common condition of pain and inflammation in the joints, the tissues, affecting 54 millions of people in US annually alone, according to the 2013-15 statistic.

In Freund's complete adjuvant (CFA) induced arthritis (AA) in rat model. oral administartion of treatment of Chaste Tree Berry seed expressed a strongly inhibited paw edema, reversed weight loss and decreased arthritis score.

According to the Second Military Medical University, the efficacy of herbal medicine for treatment of arthritis is the result in inhibition of pro inflammatory cytokins and in regulation of enzymes responsible for inflammation and pain.expression.

In support of the above, researchers in the examined hstopathological studies found that Chaste Tree Berry showed a remarkable inhibition effect in decreased synovial inflammatory infiltration and synovial lining hyperplasia in the joints in animal models.

Some also researchers suggested that Chaste tree berry reduced symptoms of pain of arthritis patient probably is associated to the blocking the stimulus by sensory neurons ability through mediating anti-inflammatory activity and interacted with the opioid system.

Taking together, Chaste Tree Berry (seed) processed an analgesic properties may be used as therapeutic potential in ameliorated symptoms and treatment of inflammatory arthritis. Large amount intake can only be prescribed by herbalists.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Therapeutic effects of standardized Vitex negundo seeds extract on complete Freund's adjuvant induced arthritis in rats by Zheng CJ1, Zhao XX1, Ai HW1, Lin B1, Han T1, Jiang YP1, Xing X2, Qin LP3.(PubMed)
(2) Antinociceptive activities of the liposoluble fraction from Vitex negundo seeds by Zheng CJ1, Huang BK, Han T, Zhang QY, Zhang H, Rahman K, Qin LP.(PubMed)

Herbal Therapy: Andrographis, The Anti Lung cancer Whole Herb Medicine

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Andrographis may be used as a possible therapeutic herbal medicine for prevention and  treatment of Lung cancer, a Taiwan study suggested.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,....

Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers are derived from epithelial cells. In US, Lung cancer is the leading cause of cancer deaths of 158,683 people, including 88,329 men and 70,354 women, according to 2007 statistic.

According to the National Chung Hsing University, andrographolide, one of the major diterpene lactones found in Andrographis paniculata exhibited antipulmonary cancer effects in a lung tumor mouse.

Dr. Tung YT, the lead autthor of the study said, "andrographolide treatment on the overexpression of VEGF can arrest the cell cycle, which induced pulmonary tumors in transgenic mice".

In non-small-cell lung cancer, intake of andrographolide, significantly enhanced the function of HLJ1, a novel tumour suppressor in used as druggable target for non-small-cell lung cancer (NSCLC).

Furthermore, andrographolide also affected the genes expression involved in the cell cycle, apoptosis and adhesion-related biological signalling, leading to inhibition of development and progression of non small cell lung cancer.

Other study insisted that the inhibition of andrographolide on non-small cell lung cancer (NSCLC) A549 cell migration and invasion is also attributed to other mechanisms beside gene expression, such as phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway in regulating the cell cycle, VEGF pathway in regulating of tumor angiogenesis,, etc.

There is no doubt that andrographolide may be a promising new anticancer agent used in suppressed tumor growth and invasion in NSCLC, but more studies are necessary to confirm the validation.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Therapeutic Potential of Andrographolide Isolated from the Leaves of Andrographis paniculata Nees for Treating Lung Adenocarcinomas by Tung YT1, Chen HL, Tsai HC, Yang SH, Chang YC, Chen CM.(PubMed)
(2) The HLJ1-targeting drug screening identified Chinese herb andrographolide that can suppress tumour growth and invasion in non-small-cell lung cancer by Lai YH1, Yu SL, Chen HY, Wang CC, Chen HW, Chen JJ.(PubMed)
(3) Andrographolide down-regulates hypoxia-inducible factor-1α in human non-small cell lung cancer A549 cells by Lin HH1, Tsai CW, Chou FP, Wang CJ, Hsuan SW, Wang CK, Chen JH.(PubMed)
(4) Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway by Lee YC1, Lin HH, Hsu CH, Wang CJ, Chiang TA, Chen JH(PubMed)

Herbal Therapy: Chaste Tree Berry, the Functional Food for Treatment of Type I and II Diabetes

Kyle J. Norton

Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite responses.

Chaste tree berry may have a potential in improved pancreatic islet regeneration in reduced risk of development and treatment of Type I and II diabetes, the renowned institute study postulated.

Diabetes are condition caused by insufficient insulin entering the bloodstream in regulation of glucose. The disease are either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reaction of cells in the immune system.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

According to the study, diabetes rats induced by streptozotocin treated with extract of chaste tree berry displayed a significant effect in increased volume density of pancreatic islet as well as percentage of β-cells and size of islet.

Dr. Oche O, the lead researcher said, "plant extracts, (exhibited) regeneration of β-cells along with β-cells repairs, in compared to non-treated diabetic control which showed complete degeneration of the islet cells".

Furthermore, the study also found that the levels of total bilirubin, direct bilirubin and unconjugated bilirubin which are associated to diabetes were significantly lower in treated group in comparison to control.

More important, in D-galactose induces pancreatic disorder along in aging mouse model, treatment of Vitex agnus-castus (VAC) demonstrated potential pancreatic protective and hypoglycemic effects through improved the size of pancreatic islets decreased in aged and D-galactose groups.

In a total of 72 adult female Naval Medical Research Institute (NMRI) mice (weighing 30-35 g) divided into 6 groups of control, VAC hydroalcoholic extract, D-galactose, D-galactose + VAC hydroalcoholic extract, aged, aged + VAC hydroalcoholic extract through subcutaneous injection of D-galactose for 45 days and, VAC hydroalcoholic extract gavaged twice a day in the last 7 days. 24 h after the last drug and extract administrations, group treated with Chaste tree berry extract or combinations of the extract showed a increased insulin and decreased serum glucose and in D-galactose level compared to other treatment groups.

The study also found, "Despite the size of pancreatic islets decreased in aged and D-galactose groups, ........... VAC hydroalcoholic extract has hypoglycemic and pancreatic protective effects in natural aged and aging model mice".

In fact,  there is also a report indicated that oral administration of once daily to diabetic rats for the period of 30 days of iridoid glucoside isolated from chaste tree berry may be as effective as glibenclamide, a known hypoglycemic drug, at concentration of 50 mg/kg b.w.
Promissingly, iridoid glucoside reversed hyperglycemia-induced biochemical changes to near normal levels.

Collectively, Chaste tree berry may be used as functional food for treatment of Type I and Type II diabetes through the hypoglycemic and pancreatic protective effects.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Pancreatic islet regeneration and some liver biochemical parameters of leaf extracts of Vitex doniana in normal and streptozotocin-induced diabetic albino rats by Oche O1, Sani I1, Chilaka NG1, Samuel NU1, Samuel A1.(PubMed)
(2) Pancreatic protective and hypoglycemic effects of Vitex agnus-castus L. fruit hydroalcoholic extract in D-galactose-induced aging mouse model by Ahangarpour A1, Oroojan AA2, Khorsandi L3, Najimi SA4.(PubMed)
(3) Antihyperglycemic effect of iridoid glucoside, isolated from the leaves of Vitex negundo in streptozotocin-induced diabetic rats with special reference to glycoprotein components by Sundaram R1, Naresh R, Shanthi P, Sachdanandam P.(PubMed)

Herbal Therapy: Andrographis, A Chemotherapeutic Agent for Treatment of Breast Cancer

Kyle J. Norton


The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Herbal Andrographis paniculata may be used as therapeutic agent for treatment and drug resistance breast cancer, a study by the renowned institute suggested.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,....

Breast cancer (malignant breast neoplasm) is condition characterized by abnormal cells growth in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma).

In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.

According to the joint study lead by the University of Kalyani, Andrographolide showed a significant inhibition of MDA-MB-231 breast cancer cell proliferation in a time- and concentration- dependent manner.

The study also found that the inhibition of breast cancer cell line proliferation with no effect on normal breast epithelial cells, through reduced oxygen species (ROS) production and increased population of apoptotic cells.

Other, in the study of the cytotoxic effect of chemical compound, 14-Deoxy-11,12-didehydroandrographolide (14-DDA), a major diterpenoid isolated from Andrographis paniculata (Burm.f.) Nees, application of the products suppressed the T-47D breast carcinoma cells caused cytotoxicity and elicited a non-apoptotic cell death.

Also in the MDA-MB-231 breast cancer cell, Andrographolide, a major chemical compound found in Andrographis exhibited a strong anti breast cancer cell growth activities in regulating the breast cancer cell proliferation, survival and progression and breast cancer metastasis through various mechanisms involved pro inflammatory pathways.

Taking together, there is no doubt that Andrographis may be used as a possible chemopreventive and chemotherapeutic agent for human breast cancers. But large amount intake should only be prescribed by herbalist.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Cytotoxicity and cell cycle arrest induced by andrographolide lead to programmed cell death of MDA-MB-231 breast cancer cell line by Banerjee M1,2, Chattopadhyay S2, Choudhuri T3, Bera R2, Kumar S2, Chakraborty B2, Mukherjee SK4.(PubMed)
(2) 14-Deoxy-11,12-didehydroandrographolide induces DDIT3-dependent endoplasmic reticulum stress-mediated autophagy in T-47D breast carcinoma cells by Tan HK1, Muhammad TS2, Tan ML3.(PubMed)
(3) Inhibition of MDA-MB-231 breast cancer cell migration and invasion activity by andrographolide via suppression of nuclear factor-κB-dependent matrix metalloproteinase-9 expression by Zhai Z1, Qu X1, Li H1, Ouyang Z1, Yan W2, Liu G3, Liu X1, Fan Q1, Tang T1, Dai K1, Qin A1.(PubMed)