Herbal Therapy: Andrographis, The Best Anti Platelet Aggregation Herbal Medicine

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

In Herbal medicine, symptoms of the diseases can only be eased gradually, depending to stage of the treatment which directly address to the cause of the disease.


A recent vitro study suggested that Andrographis paniculata exerted the enormous inhibitory effect on platelet aggregation.

Antiplatelet activity is the effect in decreased platelet aggregation and inhibited thrombus formation.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,.....

According to the Mahidol University, diterpenoids isolated from plant, including andrographolide (AP(1)) and 14-deoxy-11,12-didehydroandrographolide (AP(3)) in the thrombin-induced platelet aggregation, significantly inhibited blood clot a concentration-(1-100 microM) but not in higher doses, and time-dependent manner.

The study also suggested that the effective of this action was attributed by the inhibition of the regulation of functions in differentiate cells.

Due to inefficacy in applications of higher concentrations, Dr. said, "the extract with high level of AP(3) (Extract B) (IC(50) values=50-75 microg/ml) showed less inhibitory activity against thrombin than the extract with lower level of AP(3) (Extract A) (IC(50) values=25-50 microg/ml). These results indicate that the standardized A. paniculata extract may contain other antiplatelet compounds rather than AP(1) and AP(3), which contribute to high antiplatelet activity".

In comparison of platelet aggregation effects with non-steroidal antiinflammatory drugs (NSAID), treatment of the herbal medicine showed a strong influence on the biosynthesis of eicosanoids in cell signaling and the platelet-activating factor (PAF) with the ability to cause platelet aggregation, inflammation, and allergic response,...

The study also proposed that the mechanism of these actions  may be associated with the cardiovascular and antithrombotic activity in compared to that of non-steroidal antiinflammatory drugs (NSAID),

Other study insisted that the effects of andrographolide in platelet activation may be a result of reducing the mortality of ADP-induced acute pulmonary thromboembolism and significantly prolonged platelet clumping formation of which decrease the platelet aggregation activity.

Taking together, there is no doubt that herbal Andrographis processes an anti  Platelet Aggregation through exhibiting the functions of various mechanisms. People with bleeding disorder should only take the herbal medicine with permission of related field specialist.

Arthritis Is Curable
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Sources
(1) Inhibitory effect of Andrographis paniculata extract and its active diterpenoids on platelet aggregation by Thisoda P1, Rangkadilok N, Pholphana N, Worasuttayangkurn L, Ruchirawat S, Satayavivad J.(PubMed)
(2) Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation by Amroyan E1, Gabrielian E, Panossian A, Wikman G, Wagner H.(PubMed)
(3) A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of plateletactivation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP by Lu WJ1, Lee JJ, Chou DS, Jayakumar T, Fong TH, Hsiao G, Sheu JR.(PubMed)

Herbal Therapy: Chaste Tree Berry (Seeds), The Best in Relieved Symptoms and Treatment of Arthritis

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite outcomes.
A renowned institute study suggested that seeds of Vitex negundo L. (Verbenaceae) may have potential effects for the treatment of rheumatism and joint inflammation.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Arthritis, a common condition of pain and inflammation in the joints, the tissues, affecting 54 millions of people in US annually alone, according to the 2013-15 statistic.

In Freund's complete adjuvant (CFA) induced arthritis (AA) in rat model. oral administartion of treatment of Chaste Tree Berry seed expressed a strongly inhibited paw edema, reversed weight loss and decreased arthritis score.

According to the Second Military Medical University, the efficacy of herbal medicine for treatment of arthritis is the result in inhibition of pro inflammatory cytokins and in regulation of enzymes responsible for inflammation and pain.expression.

In support of the above, researchers in the examined hstopathological studies found that Chaste Tree Berry showed a remarkable inhibition effect in decreased synovial inflammatory infiltration and synovial lining hyperplasia in the joints in animal models.

Some also researchers suggested that Chaste tree berry reduced symptoms of pain of arthritis patient probably is associated to the blocking the stimulus by sensory neurons ability through mediating anti-inflammatory activity and interacted with the opioid system.

Taking together, Chaste Tree Berry (seed) processed an analgesic properties may be used as therapeutic potential in ameliorated symptoms and treatment of inflammatory arthritis. Large amount intake can only be prescribed by herbalists.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Therapeutic effects of standardized Vitex negundo seeds extract on complete Freund's adjuvant induced arthritis in rats by Zheng CJ1, Zhao XX1, Ai HW1, Lin B1, Han T1, Jiang YP1, Xing X2, Qin LP3.(PubMed)
(2) Antinociceptive activities of the liposoluble fraction from Vitex negundo seeds by Zheng CJ1, Huang BK, Han T, Zhang QY, Zhang H, Rahman K, Qin LP.(PubMed)

Herbal Therapy: Andrographis, The Anti Lung cancer Whole Herb Medicine

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Andrographis may be used as a possible therapeutic herbal medicine for prevention and  treatment of Lung cancer, a Taiwan study suggested.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,....

Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers are derived from epithelial cells. In US, Lung cancer is the leading cause of cancer deaths of 158,683 people, including 88,329 men and 70,354 women, according to 2007 statistic.

According to the National Chung Hsing University, andrographolide, one of the major diterpene lactones found in Andrographis paniculata exhibited antipulmonary cancer effects in a lung tumor mouse.

Dr. Tung YT, the lead autthor of the study said, "andrographolide treatment on the overexpression of VEGF can arrest the cell cycle, which induced pulmonary tumors in transgenic mice".

In non-small-cell lung cancer, intake of andrographolide, significantly enhanced the function of HLJ1, a novel tumour suppressor in used as druggable target for non-small-cell lung cancer (NSCLC).

Furthermore, andrographolide also affected the genes expression involved in the cell cycle, apoptosis and adhesion-related biological signalling, leading to inhibition of development and progression of non small cell lung cancer.

Other study insisted that the inhibition of andrographolide on non-small cell lung cancer (NSCLC) A549 cell migration and invasion is also attributed to other mechanisms beside gene expression, such as phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway in regulating the cell cycle, VEGF pathway in regulating of tumor angiogenesis,, etc.

There is no doubt that andrographolide may be a promising new anticancer agent used in suppressed tumor growth and invasion in NSCLC, but more studies are necessary to confirm the validation.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Therapeutic Potential of Andrographolide Isolated from the Leaves of Andrographis paniculata Nees for Treating Lung Adenocarcinomas by Tung YT1, Chen HL, Tsai HC, Yang SH, Chang YC, Chen CM.(PubMed)
(2) The HLJ1-targeting drug screening identified Chinese herb andrographolide that can suppress tumour growth and invasion in non-small-cell lung cancer by Lai YH1, Yu SL, Chen HY, Wang CC, Chen HW, Chen JJ.(PubMed)
(3) Andrographolide down-regulates hypoxia-inducible factor-1α in human non-small cell lung cancer A549 cells by Lin HH1, Tsai CW, Chou FP, Wang CJ, Hsuan SW, Wang CK, Chen JH.(PubMed)
(4) Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway by Lee YC1, Lin HH, Hsu CH, Wang CJ, Chiang TA, Chen JH(PubMed)

Herbal Therapy: Chaste Tree Berry, the Functional Food for Treatment of Type I and II Diabetes

Kyle J. Norton

Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite responses.

Chaste tree berry may have a potential in improved pancreatic islet regeneration in reduced risk of development and treatment of Type I and II diabetes, the renowned institute study postulated.

Diabetes are condition caused by insufficient insulin entering the bloodstream in regulation of glucose. The disease are either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reaction of cells in the immune system.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

According to the study, diabetes rats induced by streptozotocin treated with extract of chaste tree berry displayed a significant effect in increased volume density of pancreatic islet as well as percentage of β-cells and size of islet.

Dr. Oche O, the lead researcher said, "plant extracts, (exhibited) regeneration of β-cells along with β-cells repairs, in compared to non-treated diabetic control which showed complete degeneration of the islet cells".

Furthermore, the study also found that the levels of total bilirubin, direct bilirubin and unconjugated bilirubin which are associated to diabetes were significantly lower in treated group in comparison to control.

More important, in D-galactose induces pancreatic disorder along in aging mouse model, treatment of Vitex agnus-castus (VAC) demonstrated potential pancreatic protective and hypoglycemic effects through improved the size of pancreatic islets decreased in aged and D-galactose groups.

In a total of 72 adult female Naval Medical Research Institute (NMRI) mice (weighing 30-35 g) divided into 6 groups of control, VAC hydroalcoholic extract, D-galactose, D-galactose + VAC hydroalcoholic extract, aged, aged + VAC hydroalcoholic extract through subcutaneous injection of D-galactose for 45 days and, VAC hydroalcoholic extract gavaged twice a day in the last 7 days. 24 h after the last drug and extract administrations, group treated with Chaste tree berry extract or combinations of the extract showed a increased insulin and decreased serum glucose and in D-galactose level compared to other treatment groups.

The study also found, "Despite the size of pancreatic islets decreased in aged and D-galactose groups, ........... VAC hydroalcoholic extract has hypoglycemic and pancreatic protective effects in natural aged and aging model mice".

In fact,  there is also a report indicated that oral administration of once daily to diabetic rats for the period of 30 days of iridoid glucoside isolated from chaste tree berry may be as effective as glibenclamide, a known hypoglycemic drug, at concentration of 50 mg/kg b.w.
Promissingly, iridoid glucoside reversed hyperglycemia-induced biochemical changes to near normal levels.

Collectively, Chaste tree berry may be used as functional food for treatment of Type I and Type II diabetes through the hypoglycemic and pancreatic protective effects.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Pancreatic islet regeneration and some liver biochemical parameters of leaf extracts of Vitex doniana in normal and streptozotocin-induced diabetic albino rats by Oche O1, Sani I1, Chilaka NG1, Samuel NU1, Samuel A1.(PubMed)
(2) Pancreatic protective and hypoglycemic effects of Vitex agnus-castus L. fruit hydroalcoholic extract in D-galactose-induced aging mouse model by Ahangarpour A1, Oroojan AA2, Khorsandi L3, Najimi SA4.(PubMed)
(3) Antihyperglycemic effect of iridoid glucoside, isolated from the leaves of Vitex negundo in streptozotocin-induced diabetic rats with special reference to glycoprotein components by Sundaram R1, Naresh R, Shanthi P, Sachdanandam P.(PubMed)

Herbal Therapy: Andrographis, A Chemotherapeutic Agent for Treatment of Breast Cancer

Kyle J. Norton


The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Herbal Andrographis paniculata may be used as therapeutic agent for treatment and drug resistance breast cancer, a study by the renowned institute suggested.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,....

Breast cancer (malignant breast neoplasm) is condition characterized by abnormal cells growth in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma).

In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.

According to the joint study lead by the University of Kalyani, Andrographolide showed a significant inhibition of MDA-MB-231 breast cancer cell proliferation in a time- and concentration- dependent manner.

The study also found that the inhibition of breast cancer cell line proliferation with no effect on normal breast epithelial cells, through reduced oxygen species (ROS) production and increased population of apoptotic cells.

Other, in the study of the cytotoxic effect of chemical compound, 14-Deoxy-11,12-didehydroandrographolide (14-DDA), a major diterpenoid isolated from Andrographis paniculata (Burm.f.) Nees, application of the products suppressed the T-47D breast carcinoma cells caused cytotoxicity and elicited a non-apoptotic cell death.

Also in the MDA-MB-231 breast cancer cell, Andrographolide, a major chemical compound found in Andrographis exhibited a strong anti breast cancer cell growth activities in regulating the breast cancer cell proliferation, survival and progression and breast cancer metastasis through various mechanisms involved pro inflammatory pathways.

Taking together, there is no doubt that Andrographis may be used as a possible chemopreventive and chemotherapeutic agent for human breast cancers. But large amount intake should only be prescribed by herbalist.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Cytotoxicity and cell cycle arrest induced by andrographolide lead to programmed cell death of MDA-MB-231 breast cancer cell line by Banerjee M1,2, Chattopadhyay S2, Choudhuri T3, Bera R2, Kumar S2, Chakraborty B2, Mukherjee SK4.(PubMed)
(2) 14-Deoxy-11,12-didehydroandrographolide induces DDIT3-dependent endoplasmic reticulum stress-mediated autophagy in T-47D breast carcinoma cells by Tan HK1, Muhammad TS2, Tan ML3.(PubMed)
(3) Inhibition of MDA-MB-231 breast cancer cell migration and invasion activity by andrographolide via suppression of nuclear factor-κB-dependent matrix metalloproteinase-9 expression by Zhai Z1, Qu X1, Li H1, Ouyang Z1, Yan W2, Liu G3, Liu X1, Fan Q1, Tang T1, Dai K1, Qin A1.(PubMed)

Herbal Therapy: Chaste Tree Berry Expressed Various Mechanisms in Inhibition of Leukemia

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Oral Adminstrated ripe fruit of Vitex agnus-castus (Vitex) may reduce risk of various types of solid tumor cells, particularly  leukemia.

Leukemia is a condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending to the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

According to the Tokyo University of Pharmacy and Life Sciences, casticin,, the major chemical compound found in extract from the ripe fruit of Vitex agnus-castus (Vitex) exhibited strong cytotoxic activities against on leukemia cell lines, HL-60 and U-937 in dose depending manner.

Additionally, the study also expressed an interest result as the levels of cytotoxicity of Vitex/casticin were largely attributed to the degree of differentiation of leukemia cells depending to cancer cell line maturity. in compared to the HL-60 cell line with less mature U-937 cell line.

Dr. Kikuchi H, the lead author said, "casticin accounted for approximate 1% weight of Vitex. Dose-dependent cytotoxicity of Vitex and casticin was observed in both cell lines, and HL-60 cells were more sensitive to the cytotoxicity of Vitex/casticin compared to U-937 cells".

In further study, casticin, also displayed a sigmificant anti leukemia activity cells through expression molecular mechanism. apoptosis and cell cycle arrest observed through different assays.

The application of casticin yielded a result of cancer cell death at 75.3% at 12 in G2 phase in tumor cells cycle division, increased and subsequently declined to 27% at 48 h which was an indication of leukemic cell death via apoptosis and mitotic catastrophe.

Other study in support to the above differentiation, suggested that the extract from the ripe fruit of Vitex angus-castus (Vitex), inhibited the leukemia cell lines probably due to other mechanism such as significant decrease levels of intracellular reactive oxygen species (ROS) and level of gp91(phox), an important component of NADPH oxidase, in production of oxidation, and mediated cytotoxicity in HL-60 cells by regulating ROS generation...

Taking together, Chaste tree berry has a significant implication in reduced risk and treatment of leukemia through number of mechanisms, but intake of large amount should be taken with care to prevent toxicity.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines by Kikuchi H1, Yuan B, Nishimura Y, Imai M, Furutani R, Kamoi S, Seno M, Fukushima S, Hazama S, Hirobe C, Ohyama K, Hu XM, Takagi N, Hirano T, Toyoda H.(PubMed)
(2) Casticin induces leukemic cell death through apoptosis and mitotic catastrophe by Shen JK1, Du HP, Yang M, Wang YG, Jin J.(PubMed)
(3) Involvement of histone H3 phosphorylation via the activation of p38 MAPK pathway and intracellular redox status in cytotoxicity of HL-60 cells induced by Vitex agnus-castus fruit extract by Kikuchi H1, Yuan B1, Yuhara E1, Imai M1, Furutani R1, Fukushima S1, Hazama S1, Hirobe C2, Ohyama K1, Takagi N3, Toyoda H1.(PubMed)

Food Therapy: Caffeine Expressed Gene Alternation and Medicine Interaction

By Kyle J. Norton

In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Intake of coffee may have a profound effect in risk of certain disease induced  by DNA methylation, a renowned study suggested.

In a study to differentiate genome-wide DNA methylation for coffee and tea consumption in four European cohorts (N = 3,096) with DNA methylation measured from whole blood at 421,695 CpG sites distributed throughout the genome and analysed in men and women both separately and together in each cohort, researchers at the joint study lead by the Science for Life Laboratory, found that No individual sites were found to associate with men or with the sex-combined analysis for coffee.

Contrastively, in the re examine of two placebo-controlled studies, among subjects taking creatine, for whom higher caffeine intake was associated with more rapid progression of PD, according to the DNA samples and caffeine intake data.

Although GRIN2A genotype was not associated with the rate of clinical progression of PD in the placebo group, but intake of coffee may have interact with creatine in many different ways in these group of patients, particularly in in the creatine group with high levels of caffeine intake,

These result indicated an important results

1. Coffee and caffeine intake do not exert change of DNA in healthy individuals.

2. Caffeine exposed a strong interaction with some medication, such as creatine to induce DNA change 

3. These inaction increased severity of  the disease expression and progression 

Dr. Simon DK, the lead author said, "(the study demonstrated an example of) a genetic factor interacting with environmental factors illustrates the complexity of gene-environment interactions in the progression of PD.

In support of the above analysis, Dr. Yamada-Fowler N, the lead researchers of another joint study lead by the Linköping University, insisted that caffeine expresses a strong effect in increased risk PD progression by interaction with gene GRIN2A, instead of group with intake of creatine 

The findings information, suggested that caffeine may have a profound effect in interaction with some medication in induced some genes change or induce DNA change without presence of medicine intake in some diseases.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Tea and coffee consumption in relation to DNA methylation in four European cohorts by Ek WE1, Tobi EW2, Ahsan M1, Lampa E3, Ponzi E4,5, Kyrtopoulos SA6, Georgiadis P6, Lumey LH7, Heijmans BT8, Botsivali M6, Bergdahl IA9, Karlsson T1, Rask-Andersen M1, Palli D10, Ingelsson E11,12, Hedman ÅK12, Nilsson LM13, Vineis P14, Lind L15, Flanagan JM16, Johansson Å1; Epigenome-Wide Association Study Consortium(PubMed)
(2) Caffeine, creatine, GRIN2A and Parkinson's disease progression by Simon DK1, Wu C2, Tilley BC3, Lohmann K4, Klein C5, Payami H6, Wills AM7, Aminoff MJ8, Bainbridge J9, Dewey R10, Hauser RA11, Schaake S12, Schneider JS13, Sharma S14, Singer C15, Tanner CM16, Truong D17, Wei P18, Wong PS19, Yang T20.(PubMed)
(3) Caffeine interaction with glutamate receptor gene GRIN2A: Parkinson's disease in Swedish population by Yamada-Fowler N1, Fredrikson M2, Söderkvist P1.(PubMed)