Friday, 6 October 2017

Herbal Therapy: Chaste Tree Berry, The Best Hepatoprotective Whole Herb Medicine

Kyle J. Norton


In herbal medicine, symptoms of the diseases can only be eased gradually, depending to stages of the treatment which directly address to the cause of the disease.

Chaste tree beery is found to associate with reduced risk of liver damage and diseases through various mechanisms, the recent study suggested

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

In acetaminophen-induced hepatotoxicity in mice study, oral administration of chaste tree berry increased significantly in expression of levels of antioxidant in inhibition of free radicals domino' effect and levels of ferric ion in induced hepatotoxicity caused by acetaminophen.

According to the Al-Hikmah University, Hepatoprotective effects of chaste tree berry may also mediate the alternative effects of acetaminophen in serum alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, albumin and total bilirubin levels which can also contribute to hepatoxicity.

Dr. Ajiboye TO said, " Vitex doniana fruits possess antioxidant properties and halted acetaminophen-mediated oxidative rout on cellular proteins, lipids and DNA, made possible by β-sitosterol, platycodin D, apigenin, saikosaponin, chrysin and ellagitanin, (the antioxidants) in the extract".

Furthermore, ethanol extract Vitex glabrata (EEVG) on carbon tetrachloride-induced liver damage in rats, .displayed also antioxidant activity in inhibited superoxide dismutase, GSH, lipid peroxidation (LPO), catalase and peroxidase levels in liver homogenate.

Pre-treatment of the extract illustrated a strong inhibited effect against levels of LPO in CCl(4)-intoxicated livers and reduced the elevated serum levels of chemical compounds which can cause liver damage.

In fact, the extract display a enormous hepaprotective effect similar to those of silymarin through enhancing antioxidant mechanisms of its components, predominantly artemetin.

According to the The Vinayaka Mission’s College of Pharmacy study, in the CCl4 induced hepatic injury in albino rats, vitex extract not only is comparable to the standard drug, silymarin (100 mg/kg, p.o.), but also altered serum biomarker enzyme levels which were damage through injection of CCI4, to near normal in treated rats.

Taking together, there is no doubt that Chaste tree berry may process a protective effect in reduced risk of harmful chemicals and drugs induced liver damage, but injection of large amount should be taken with care.




Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Standardized extract of Vitex doniana Sweet stalls protein oxidation, lipid peroxidation and DNA fragmention in acetaminophen-induced hepatotoxicity by Ajiboye TO1.(PubMed)
(2) Antioxidant and hepatoprotective effects of ethanol extract of Vitex glabrata on carbon tetrachloride-induced liver damage in rats by Sridevi VK1, Chouhan HS, Singh NK, Singh SK.(PubMed)
(3) Effect of ethanol extract of flowers of Vitex trifolia Linn. on CCL4 induced hepatic injury in rats by Anandan R1, Jayakar B, Karar B, Babuji S, Manavalan R, Kumar RS.(PubMed)

Food Therapy: Black Bean, in Reduced Risk and Treatment of Colon Cancer

Kyle J. Norton

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending to stage of the treatment which directly address to the cause of disease.

Black or common bean with abundant fiber may be considered as function foods in reduced risk and treatment of colon cancer, a respectable institute suggested.

Colon cancer is a medical condition of the abnormal proliferation of cells in large intestine.

Black bean, a small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

In a study of rats injected with azoxymethane (AOM)-induced colon cancer or saline and one week later administered an AIN, black bean (BB) and soy flour (SF)--based diet, researchers found that mice fed with black bean showed a significant expression in attenuated gene expression in coloncarcinogenesis by modulating cellular kinetics and reducing inflammation.

Others in the experiment to test the prevalence of high bean intake and low incidence of colon cancer in many Latin American countries in 53-wk-old weanling male F344 rats randomly assigned by weight to the following groups: control (11 rats), casein diet (21 rats), and bean diet (21 rats), with animals fed the casein and bean diets treated with the carcinogen azoxymethane (AOM) once weekly for 2 wk, the results returned showed a significantly fewer colon adenocarcinomas (P < 0.05) inrat fed with bean diet in compared control and rats fed the casein diet.

Rats fed with bean diet also expressed a lesser in tumor multiplication observed by tumors per tumor-bearing rat than in casein-fed rats.

Dt. Hughes JS, the lead researcher said, "dry beans contain anticarcinogenic compounds capable of inhibiting AOM-induced colon cancer in rats. However, the specific anticarcinogenic components within dry beans have not been identified".

But suggested that the efficacy of bean in reduced colon cancer risk may be results of the dietary fiber, phytochemicals or other components within dry beans,...

Promisingly, the results of rats fed a modified AIN-93G diet (control) or diets containing 75% black beans or 75% navy beans for 4 wk, and then colon cancer initiated by administration of two injections of azoxymethane 1 wk apart, also postulated a lower incidence  of colon cancer in rats fed the black bean (9%) in compared navy bean (14%) diets than in rats fed the control diet (36%) at 31 weeks.

In fact, rats fed the black bean also a significantly lower of total tumor multiplicity in compared to control.

Black bean consumption addressed a significant evidence that change of diet may exhibit  more controlled appetites, induced less body fat, and improved greater concentrations of butyrate in the distal colon, thus ameliorating prevalence of colon cancer

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Microarray Analyses of Genes Differentially Expressed by Diet (Black Beans and Soy Flour) during Azoxymethane-Induced Colon Carcinogenesis in Rats by Rondini EA1, Bennink MR.(PubMed)
(2) Dry beans inhibit azoxymethane-induced colon carcinogenesis in F344 rats by Hughes JS1, Ganthavorn C, Wilson-Sanders S.(PubMed)
(3) Consumption of black beans and navy beans (Phaseolus vulgaris) reduced azoxymethane-induced colon cancer in rats by Hangen L1, Bennink MR.(PubMed)

Herbal Therapy: Chaste Tree Berry for Treatment of High Levels Testosterone Induced Male Sexual Libido, Acne and Prostate Disease

Kyle J. Norton


The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Recent study conducted by renowned institute suggested that Vitex agnus castus (Vac.) may have a potential in decreased over production of testosterone on the male reproductive physiology.

Testosterone is a male steroid hormone played an important role in male reproductive organs and building bone and muscle mass as well as stimulating sexual desire in both sexes.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

In the study of hydroalcoholic Vac. extract (extraction by percolation technique) with the following doses: 65, 165, 265, 365 and 465 mg kg-', bromocriptine as a dopamine receptor agonist (5, 10, 20 mg kg(-1)) and haloperidol as a dopamine receptor antagonist (1, 1.5, 2, 2.5, 3 mg kg(-1)) injection male mice treated with chaste tree berry extract or combination of the extract showed a significant decrease of levels of testosterone in compared to other treatment groups.

Dr. Nasri S, the lead author said, ". LH and testosterone were measured by Radio Immuno Assay (RIA). LH and testosterone, showed significant decrease in bromocriptine group and haloperidol increased these hormones. Vac. extract decreased significantly the LH and testosterone levels. The coadministration of Vac. extract and bromocriptine decreased LH and testosterone".

The study also found that Vitex agnus castus extract influences the neurotransmiters such as dopamine in regualted LH and testosterone secretion.

In confirm to the efficacy of chaste tree berry in reduced testosterone production, Vitex agnus castus L. (Vit.) fruit extract with 1650 mg/kg tested on male mice model with the doses (65, 165, 265, 365, 465 mg/kg) injected intraperitoneally for 30 days in 5 groups of animals, all tested mice showed a decreased testosterone levels in dose depending manner.

The researchers also insisted that through the Radio Immuno Assay (RIA), Vit. fruit extract has an anti-androgenic effect and probably acts through the Hypothalamic-Pituitary-Gonadal (HPG) axis and the side effects only appear after a long time of their usage.

Dr Jillian Stansbury, not the author of the studies said, " (due to the effects of chaste tree berry in reduced LH levels and testosterone levels ) that Vitex may improve symptoms of high testosterone levels in men, including excessive libido, acne, and prostatic disease."

The reduced levels of testosterone of the herbal medicine may be beneficiary for patients with high levels of testosterone induced of sexual libido, acne and abnormal prostate expression.


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The effects of Vitex agnus castus extract and its interaction with dopaminergic system on LH and testosterone in male mice by Nasri S1, Oryan S, Rohani AH, Amin GR.(PubMed)
(2) The Effects of Vitex agnus castus L. Extract on Gonadotrophines and Testosterone in Male Mice(Researchgate)
(3) WOMEN’S HERBS” FOR MEN By Editor1 Posted November 8, 2010
In Botanical Medicine, Endocrinology, Fertility, Men's Health, Nature Cure, Oncology, Dr Jillian Stansbury

Thursday, 5 October 2017

Food Therapy: Black Bean in Attenuated Risk and Treatment of Prostate Cancer

By Kyle J. Norton

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Intake of black bean regular may associate to ameliorated risk  and treatment of prostate cancer, an Asian study reported. Particularly, people who follow Southern pattern of diet showed a reduction in risk of prostate cancer with approached statistical significance.

Black bean, a small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

According to the National Taiwan University,fermentation products BN999, included black bean processed an anti prostate cancer effect through expression of prostate adenocarcinoma PC-3 cell line.

BN999, the product mixture induced cancer cell death by activating the protein gene involved pro cancer cell apoptosis via cell mediatory activities, including a network of membranous anatomical structure and double membrane-bound organelle.in energy conversion.

Most importantly, BN999 target prostate and other cancer cell without affecting the normal human cells and inducing obvious side effects.

Further more, water-soluble black bean condensed tannins isolated from black beans showed a significant activity in induced cancer cell death by apoptosis without affecting the growth of normal cells, in dose dependend manner.

Additionally, the study also addressed that the efficacy of water-soluble in induced prostate cancer cell death may be attributed to direct effect in decrease cancer cell energy molecule and formation of cell structure.

Dr. Bawadi HA, the lead author indicated, after 24 h of injection, water-soluble black bean condensed tannins showed a strong reduced coagulation of blood in stimulated cancer cell migration and regulated mechanisms involved growth of prostate cancer in formation of new blood vessels.

The finding evidenches suggested that black bean with plenty of phytochemicals may be considered as functional food  used alone or combination with other super foods for attenuated risk and treatment of prostate cancer.


Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Soureces
(1) Fermentation product of soybean, black bean, and green bean mixture induces apoptosis in a wide variety of cancer cells by Chia JS1, Du JL, Wu MS, Hsu WB, Chiang CP, Sun A, Lu JJ, Wang WB.(PubMed)
(2) Dietary patterns and prostate cancer risk in the National Health and Nutrition Examination Survey Epidemiological Follow-up Study cohort by Tseng M1, Breslow RA, DeVellis RF, Ziegler RG.(PubMed)

Herbal Therapy: Chaste Tree Berry, a Valuable Chemotherapeutic Agent for Treatment of Cancers

Kyle J. Norton.
In herbal medicine, symptoms of the diseases can only be eased gradually, depending to stages of the treatment which directly address to the cause of the disease.

Chaste tree berry is found to exhibit a significant anti cancer activity, a recent study by renowned study advised.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Cancer is a class of diseases characterized by cells growing and multiplying disordered and uncontrollable way in our body. In the late stage, cancer cell may travel away from originated site
to infect other tissues and organs.

According to the Tianjin Institute for Biomedicinal Research, in the evaluated the apoptosis-inducing effect of chaste tree berry, using observation under light microscope, flow cytometric analysis and agarose gel electrophoresis, vitexicarpin, a flavonoid found in chaste tree berry significantly inhibited  proliferation of human cancer cells lines A2780(human ovarian carcinoma), HCT-15(human, colon, colorectal adenocarcinoma), HT-1080(fibrosarcoma cell line) and K562(Human chronic myeloid leukemia cells), depending to the concentration.

Dr. Wang HY the lead researcher in the study said, "Vitexicarpin induces apoptosis....  via mitochondria(in regulated cell metabolism)-controlled apoptotic pathway".

In support of the above analysis, the crude extract prepared with ethanol from dried ripened Vitex agnus-castus fruits exerted a strong cytotoxicic effects against cancer cell lines of human uterine cervical canal fibroblast (HCF), human embryo fibroblast (HE-21), ovarian cancer (MCF-7), cervical carcinoma (SKG-3a), breast carcinoma (SKOV-3), gastric signet ring carcinoma (KATO-III), colon carcinoma (COLO 201), and small cell lung carcinoma (Lu-134-A-H) cells.

The inhibition of the extract is attributed to the effect on cell death through apoptosis and increased intracellular oxidation in the tumor cells.

Other researchers suggested that the cytotoxic effects.of Chaste tree berry may be involved various aspects, including the JNK (opotosis) pathway. as indicated in the new native lignan VB6 study.

Taking together, there is no doubt, that chaste tree berry may be considered as a valuable chemotherapeutic agent for treatment of various types of cancer, depending to further evaluation.


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) [Vitexicarpin, a flavonoid from Vitex trifolia L., induces apoptosis in K562 cells via mitochondria-controlled apoptotic pathway].[Article in Chinese] by Wang HY1, Cai B, Cui CB, Zhang DY, Yang BF.(PubMed)
(2) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth by Ohyama K1, Akaike T, Hirobe C, Yamakawa T.(PubMed)
(3) Vitexin 6, a novel lignan, induces autophagy and apoptosis by activating the Jun N-terminal kinase pathway by Zhou J1, Hu H, Long J, Wan F, Li L, Zhang S, Shi YE, Chen Y.(PubMed)

Food Therapy: Green Tea, The Best Anti Metabolic Syndrome Whole Food Medicine

Kyle J. Norton


Green tea may be served as functional food for reduced risk and treatment of metabolic syndrome, a renowned institute study suggested

Metabolic Syndrome is a group of risk factors used to calculate the incidence of early onset of diabetes and cardiovascular diseases.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine ,or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will do the trick.

In a total of 35 obese participants with metabolic syndrome randomly assigned to receive one of the following for 8 weeks: green tea (4 cups per day), control (4 cups water per day), or green tea extract (2 capsules and 4 cups water per day), blood samples collected from green tea and green tea extract treated groups showed a significantly increased plasma antioxidant capacity (1.5 to 2.3 μmol/L and 1.2 to 2.5 μmol/L, respectively in compared to control group.

The study also found that the efficacy of green tea in ameliorated early progression of metabolic syndrome is attributed to the improved expression of serum antioxidant enzymes (glutathione peroxidase, glutathione, catalase) and plasma antioxidant capacity in inhibited free radicals in exhibition of pro inflammatory cytokins.

Furthermore, in the total of 55 obese men and women recruited, injection of 280 and 360 g GTRB provided daily totals of 123.2 and 158.4 mg caffeine, and 188.3 and 242.1 mg of epigallocatechin gallate significantly reduced expression of metabolic syndrome in attenuated weigh gain, high-density lipoprotein-cholesterol, triglycerides, and glucose concentrations.

More importantly, the study also found that administration of green tea also reduced levels of blood pressure in obese subjects but can not maintain the weigh loss after study.

Other researchers in the investigation of decaffeinated green tea extract (GTE) and voluntary running exercise (Ex) alone or in combination against obesity and metabolic syndrome in high fat (HF) fed C57BL/6J mice, insisted that combination of green tea injection and exercise treatment reduced final body mass (27.1% decrease) and total visceral fat mass (36.6% decrease), levels of fasting blood glucose (17% decrease), plasma insulin (65% decrease), and insulin resistance (65% decrease) compared to HF-fed mice.

Taking together, green tea may be one of best candidates used for prevention of onset and treatment of metabolic syndrome in  adult population, but long term injection of large amount may induced liver and kidney toxicity as shown in previous articles.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green tea supplementation increases glutathione and plasma antioxidant capacity in adults with the metabolic syndrome by Basu A1, Betts NM, Mulugeta A, Tong C, Newman E, Lyons TJ.(PubMed)
(2) Effects of rye bread enriched with green tea extract on weight maintenance and the characteristics of metabolic syndrome following weight loss: a pilot study by Bajerska J1, Mildner-Szkudlarz S2, Walkowiak J1,3.(PubMed)
(4) Voluntary exercise and green tea enhance the expression of genes related to energy utilization and attenuate metabolic syndrome in high fat fed mice by Sae-Tan S1, Rogers CJ, Lambert JD.(PubMed)

Herbal Therapy: Chaste tree berry, The Best Whole Herb Medicine Exhibits Anti-Nociceptive in PMS

By Kyle J. Norton

The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Premenstrual syndrome is a faulty function of the ovaries related to the women's menstrual cycle, it effects a women's physical and emotional state, and sometimes interferes with daily activities as a result of hormone fluctuation.
Anti nociceptive effect is the term used to indicate the process in blocking the detection of a painful stimulation by sensory neurons.

Chaste tree berry may have a potential effect in reduced pain associated to symptoms of premenstrual syndrome, a renowned institute study suggested.

In an acetic-acid-induced writhing and metoclopramide-dihydrochloride-induced hyperprolactinemia mice study, mice treated with Chaste tree berry factions showed a significantly effective in expression of anti-nociceptive and anti-hyperprolactinemia activities.

The study also found that the fraction extracted from the herb also exerted anti-nociceptive activity in a dose-dependent manner (10-50 mg/kg body wt., i.g.).

Dr. Hu Y, the lead researcher in the study said, "Our results indicate that the presence of flavonoids such as Casticin in this plant may be responsible for the (anti-nociceptive and anti-hyperprolactinemia) activity effects. Casticin has potent analgesic and anti-hyperprolactinaemia properties, is likely to be one of the active components of Fructus Viticis, and may have a role in treating PMS (premenstrual syndrome)".

Further study in support of above differentiation also insisted that the 80% ethanol extract isolated from the herbal medicine showed the highest anti-nociceptive activity in acetic acid-induced writhing test in ICR mice in comparison with other factions. The study also indicated that the anti-nociceptive activity is mediate through inhibition of proinflammatory activity rather than through opioid receptors.

The evaluation of petroleum ether fraction (PEF) from the aqueous ethanol extract of Chaste tree berry at doses of 12, 24, and 48 mg/kg body weight, in nociceptive mouse models induced by intraperitoneal acetic acid and sub-plantar formalin injections and on thermal nociception in the hot-plate test, produced significant dose-related inhibitions on chemical nociception, probably due to partially mediated by its anti-inflammatory activity.

Taking together, the anti-nociceptive effect of Chaste tree berry should be beneficiary in reduced symptoms and treatment of women with premenstrual syndrome and improved quality of social life.
Large amount intake of herbal medicine can be prescribed by related field specialist, including Chaste tree berry.



Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Anti-nociceptive and anti-hyperprolactinemia activities of Fructus Viticis and its effective fractions and chemical constituents by Hu Y1, Xin HL, Zhang QY, Zheng HC, Rahman K, Qin LP.(PubMed)
(2) Bioactivity-guided fractionation for analgesic properties and constituents of Vitexnegundo L. seeds by Zheng CJ1, Tang WZ, Huang BK, Han T, Zhang QY, Zhang H, Qin LP.(PubMed)
(3) Antinociceptive activities of the liposoluble fraction from Vitex negundo seeds by Zheng CJ1, Huang BK, Han T, Zhang QY, Zhang H, Rahman K, Qin LP.(PubMed)