Food Therapy: Coffee, A linear Association to Reduced Risk and Progression of Parkinson's Disease

By Kyle J. Norton


In compared to herbal medicine, food therapy even takes longer  to ease symptoms, depending to stage of the treatment which directly addresses to the cause of disease.

Intake of coffee caffeine regularly are associated to a significantly attenuated risk of neurodegenerative conditions, particular in the onset of Parkinson's diseases, a recent study suggested.

Parkinson's disease is neuro degenerative disease caused by deficiency of the dopamine and.degeneration of the basal ganglia of the brain, affecting muscular normal function.

Coffee, becoming a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

According to the Harvard School of Public Health, Boston, in compared population comprised 47,351 men and 88,565 women free of Parkinson's disease, stroke, or cancer at baseline, caffeine intake is associated to reduced risk and progression of PD, in compared the top and bottom one-fifth men participants. No effect is found for decaffeinate coffee intake regardless to numbers of cup consumed.

Interestingly, among women, numbers of caffeinated coffee intake daily have a strong implication in attenuated risk of PD linearly, in compared to lowest intake of moderated intake groups.

Further more, a case-control study conducted in western Washington State in 1992-2000. Incident PD cases (n = 210) and controls (n  = 347) with frequency matched on gender and age identified from enrollees of the Group Health Cooperative health maintenance organization, returned questionnaires by participants indicated, consumption of 2 cups/day showed a strong expression in reduced risk of PD.

More importantly, in the review of twenty-six studies included: 7 cohort, 2 nested case-control, 16 case-control, and 1 cross-sectional study, the  total relative odd ratio for the association between caffeine intake in low to moderate groups and PD was 0.75.

But, in cohort studies, reduced risk of PD significantly decreased if only women participants were considered.

Researchers, at above study revealed that PD risk is associated to a linear relation between levels of caffeine exposure of relative odd ratio of 0.76, per 300 mg caffeine intake.

Taking together, there is no doubt that risk of PD has an extremely inverse association to caffeine intake, particular in moderated drinkers.

 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Can coffee consumption lower the risk of Alzheimer's disease and Parkinson's disease? A literature review by Wierzejska R1.(PubMed)
92) Prospective study of caffeine consumption and risk of Parkinson's disease in men and women by Ascherio A1, Zhang SM, Hernán MA, Kawachi I, Colditz GA, Speizer FE, Willett WC.(PubMed)
(3) Parkinson's disease risks associated with cigarette smoking, alcohol consumption, and caffeine intake by Checkoway H1, Powers K, Smith-Weller T, Franklin GM, Longstreth WT Jr, Swanson PD.(PubMed)

Herbal Therapy: Chaste tree berry, the Anti Prostate Cancer Whole Herb

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Believe or not, Chaste tree berry is shown to process a significant anti prostate cancer activity, a study of a renowned University proposed.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Prostate cancer is a condition in which the cells of prostate has become cancerous. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

According to the University of Basel, extracts of Vitex agnus-castus fruits (VACF) inhibited human prostate epithelial cell lines (BPH-1, LNCaP, PC-3) in different stages of androgen responsiveness, through its antiproliferative activity in induced apoptosis and potential cytotoxicity.

Dr. Weisskopf M, the lead author said, "The extract inhibited proliferation of all three cell lines in a concentration-dependent manner with IC (50) values below 10 microg/mL after treatment for 48 h. Cell cycle analysis and DNA fragmentation assays suggest that part of the cells were undergoing apoptosis" and " 

Furthermore, the extract may be useful for the prevention and/or treatment of benign prostatic hyperplasia.

Other study in proposal of five herbal supplements, designated FB, FM, PP, HF and FBL101, containing different combinations of various natural herbs such as licorice, black cohosh, Dong Quai, false unicorn and vitex berry root extracts, found that the five herbal supplements inhibited PC3 tumor growth by 53%, 75%, 80%, 81% and 87%, respectively without altering plasma testosterone levels relative to the untreated control.

Supplement of vitex berry root extracts significantly reduced VEGF levels, a product produced by cancer cells in large quantities, in mediation of angiogenesis through blocking the forming of new blood vessels in PC3 and CWR22R tumors,

There is no doubt that Chaste tree berry and its supplement may be used as preventive and therapeutic agents in reduced risk and treatment of prostate cancer. But intake of large amount should only be given by herbalist to prevent toxicity.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) A Vitex agnus-castus extract inhibits cell growth and induces apoptosis in prostate epithelial cell lines by Weisskopf M1, Schaffner W, Jundt G, Sulser T, Wyler S, Tullberg-Reinert H.(PubMed)
(2) Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice by Ng SS1, Figg WD.(PubMed)

Herbal Therapy: Green Tea, Reduced risk of Early onset and Progression of Cognitive Impairment

By Kyle J. Norton


The use of plants for healing purposes has been predated long before the existence of modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Green tea injection is associated to reduced risk of age-related cognitive decline, a recent study postulated.

Cognitive impairment is a condition of decline of memory and thinking skills due to aging considered as an early sign of neuro degenerative diseases.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine ,or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a piece of ginger will solve the problem.

In a total of 12 elderly nursing home residents with cognitive dysfunction, participants who drink green tea powder 2 g/day for 3 months showed a significantly improved cognitive performance and reduced the progression of cognitive dysfunctionindicated by Mini-Mental State Examination Japanese version (MMSE-J) score.

Other study (Japanese residents aged >60 years from Nakajima, Japan (the Nakajima Project) of 723 participants with normal cognitive function at a baseline survey (2007-2008), the 490 completed the follow up survey in 2011-2013, suggested that incidence of dementia and cognitive impairment are lower among individuals who consumed green tea 1-6 days per week compared with individuals who did not consume green tea at all.

Additionally, according to the double-blind, randomized controlled study of 39 nursing home residents with cognitive dysfunction (four men, 29 women) divided into two group either with
consumption of 2 g/day of green tea powder (containing 220.2 mg of catechins) or placebo powder (containing 0.0 mg of catechins), green tea treated group showed a significantly reduced cognitive dysfunction in 3 months follow up in compared to placebo.

The efficacy of green tea in decreased progression of cognitive impairment in the short term may be attributed to ameliorated oxidative stress and levels of low-density lipoprotein.

Taking together, Green tea may process a potential in reduced risk of early onset and progression of cognitive decline in aging population, but long term and large amount injection should be taken with care.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green tea consumption affects cognitive dysfunction in the elderly: a pilot study by Ide K1, Yamada H2, Takuma N3, Park M4, Wakamiya N5, Nakase J6, Ukawa Y7, Sagesaka YM8.(PubMed)
(2) Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline by Noguchi-Shinohara M1, Yuki S1, Dohmoto C1, Ikeda Y1, Samuraki M1, Iwasa K1, Yokogawa M2, Asai K3, Komai K4, Nakamura H5,(PubMed)
(3) Effects of green tea consumption on cognitive dysfunction in an elderly population: a randomized placebo-controlled study by Ide K1, Yamada H2, Takuma N3, Kawasaki Y1, Harada S1, Nakase J4, Ukawa Y4, Sagesaka YM4.(PubMed)

Food Therapy: Beet, the Potent Anti Platelet Aggregation Whole Food

By Kyle J. Norton
In compared to herbal medicine; food therapy even takes longer to ease symptoms, depending to stage of the treatment which directly address to the cause of the disease.

Platelet aggregation is natural reaction of wound healing process of blood clotting in damage and injure of our body, to prevent infection and inflammation.

Beet, best known as the beetroot or garden beet and belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.

Beet may process a significant effect in improved blood circulation through anti platelet aggregation  activity, a recent and renowned study suggested

According to the Barts & the London School of Medicine and Dentistry, dietary rich of nitrate vegetable or fruit, such as beet showed to exhibited vascular function in promotion of blood vessel and blood circulation function, thus reducing risk CVD.

In healthy volunteers, ingestion of a dietary nitrate load (beetroot juice 500 mL), approximately 3 hours after, correlated with peak increases in plasma nitrite concentration showed a significant effect in attenuated platelet aggregation in response to collagen and adenosine diphosphate (ADP), in cell energy metabolism. And decreased plasma nitrite, may block the decrease in blood pressure and abolished the inhibitory effects on platelet aggregation.

This findings suggested that regular drinking of dietary nitrate from food sources is necessary for maintenance of a healthy heart through decreased platelet aggregation and reduced blood pressure.

In 2 randomised crossover studies each in 24 (12 of each sex) healthy subjects with oral administrated dietary nitrate (250 ml beetroot juice) or potassium nitrate capsules (KNO3, 8 mmol) vs placebo control on platelet reactivity, group treated with nitrate component showed a strong inhibition of platelet aggregation.

The study also demonstrated that inorganic nitrate ingestion, whether via the diet or through supplementation, may have a gender preference in decreased platelet reactivity in healthy males but not females counterpart.

Dr. Velmurugan S, the lead author said, " dietary nitrate (may be benefit) as an adjunct to current antiplatelet therapies to prevent atherothrombotic complications".

According to the review of the National Heart and Lung Institute, in vitro and in vivo, dietary nitrite exhibited cGMP in mediated the levels of platelet aggregation through expression of nitric oxide actions, and in a model of thromboembolic radiolabeled platelet aggregation, injection of dietary nitrate or supplement showed a significantly inhibited platelet function in eNOS(-/-) mice.

Collectively,  beet with high amount of dietary nitrate may be used as functional food combined conventional treatment in reduced risk of platelet aggregation in induction of CVD.

It is my advised that people who are taking anti platelet aggregation medicine should consult with their doctors before applying large amount beet juice or juice with high concentration of nitrate.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite by Webb AJ1, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, MacAllister R, Hobbs AJ, Ahluwalia A.(PubMed)
(2) Antiplatelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex by Velmurugan S1, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ, Poole A, Ahluwalia A.(PubMed)
(3) Role of inorganic nitrate and nitrite in driving nitric oxide-cGMP-mediated inhibition of platelet aggregation in vitro and in vivo by Apostoli GL1, Solomon A, Smallwood MJ, Winyard PG, Emerson M.(PubMed)

Herbal Therapy: Green tea, The best Beverage for Lower Coronary Artery Disease Risk

By Kyle J. Norton


People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stage of the treatment which directly address to the cause of disease.

Recent study conducted by a respectable institute suggested that green tea may have a potential effect in reduced risk and treatment of coronary artery disease.

Coronary artery disease is a condition of narrowing coronary arteries, caused by hardening arterial wall, cholesterol building up in the arteries, leading to blockage of the blood flow in the arteries.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine ,or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will do the trick of neutralization.

According to the review of literature of a study of 22 healthy volunteers, injection of green tea 7 cups/day exhibited anti cholesterol effects through modifying the low-density lipoprotein (MDA-LDL) concentrations and decreasing plasma C-reactive protein and interleukin (IL)-6 concentrations involving inflammatory expression.

Green tea consumption of less of 1 cup a day in 725 patients undergoing coronary angiography, is found to associate to lower risk of myocardial infarction (MI) in compared to CVD patients without MI and patients without CAD.

Dr. Ohmori R, the lead author said," Green tea consumption was found to be inversely associated with MI in Japanese patients" and " The protective effect of green tea against atherosclerosis is more likely to be because of the inhibitory effect of LDL oxidation than because of anti-inflammatory effect.".

Additionally, Japanese population with green tea drinking habit, showed a significantly reduced risk of a decreased incidence of coronary artery disease (CAD), due to the presence of abundant polyphenolic antioxidants.

In a group of comprised 203 patients who underwent coronary angiography (109 patients with significant coronary stenosis and 94 patients without), coronary artery disease (CAD) is associated inversely in regular green tea drinking group.

The study showed that green tea intake per day was an independent predictor for CVD based on a multivariate logistic regression analysis. but  not a predictor of cardiovascular diseases based on the Cox proportional hazard model.

Continuously, in researching the data of PUBMED and EMBASE for studies conducted from 1966 through November 2009 filed the following results:
1. 5 studies on green tea. indicated the lower relative risk is depended significantly between the highest green tea consumption and reduced risk of CVD.
2. The risk of CVD is reduced by 10% for every additional cup of green tea intake.

Taking together, green tea may be used as a functional food of healthy adultd with a higher risk CVD.
However, long term and large amount green tea consumption should be taken with care to prevent toxicity.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Antioxidant beverages: green tea intake and coronary artery disease by Ohmori R1, Kondo K2, Momiyama Y3.(PubMed)
(2) Effects of green tea intake on the development of coronary artery disease by Sano J1, Inami S, Seimiya K, Ohba T, Sakai S, Takano T, Mizuno K.(PubMed)

Herbal Therapy: Andrographis Paniculata, The Best Gastroprotective Whole Herb Medicine

By Kyle J. Norton

The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Andrographis paniculata showed to improve the gastric tone and prevent gastric dysfunction through the protection of its antioxidants, the renowned institute suggested.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, ....

Gastroprotective effect is a condition involved enhances the function of digestive system against the harmful organisms in induced chronic indigestion.

In the study of  gastric ulcer induced by ethanol, aspirin, pylorus ligation and cold restraint stress models, rats treated with rats pretreated with HAEAP (100,200,500mg/kg b. wt for 30 days) of andrographis paniculata expressed a significant ulcer reduction, in dose dependent manner, according to the Bharathi Women's College.

Dr. Panneerselvam S, the lead author said, "The ulcer preventing effect of HAEAP may partly be due to its regulating effect on H(+)K(+)ATPase activity and /or mucin preserving effects" and "The flavonoids present in the HAEAP might be responsible for the gastroprotective action probably by maintaining the antioxidants and thiol status in the gastrointestinal tract".

In support of the above differentiation, the review of a period of 1 year from 2014-2015, using semi-structured questionnaires from different traditional Bengali people having knowledge on medicinal plants, out of 49 plants under 46 genera belonging to 33 families, andrographis paniculata is one of the most prominent plants used among the people of Southern Assam for treating digestive system disorders (DSD).

Furthermore, seed ethyl acetate, acetone and methanol extracts of Andrographis paniculata (Burm.f.) Wall. ex Nees has drawn a lots of scientists attention due to the limit success of chemical anthelmintics, a group of antiparasitic drugs (levamisole, flubendazole, and thiabendazole) in reduced gastrointestinal diseases.

 In animal controls,  ED(50), an methanol extract of A. paniculata at dose of 2.90 mg/ml, and in larval development assay at ED(50) of dose 4.26 mg/ml, showed a significant effects against sheep parasite, Haemonchus contortus.

Taking together, there is  no doubt that andrographis paniculata consisted a strong gastroprotective effect against the activities of harmful organisms, including parasites and may be used as functional food in improving digestive functions.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) A biochemical study on the gastroprotective effect of hydroalcoholic extract ofAndrographis paniculata in rats by Panneerselvam S, Arumugam G(PubMed).
(2) Plant utilization against digestive system disorder in Southern Assam, India by Choudhury PR1, Choudhury MD1, Ningthoujam SS2, Mitra A1, Nath D3, Talukdar AD4.(PubMed)
(3) Anthelmintic activity of botanical extracts against sheep gastrointestinalnematodes, Haemonchus contortus by Kamaraj C1, Rahuman AA, Elango G, Bagavan A, Zahir AA.(PubMed)

Hormone Therapy: Progesterone in Reduced Risk of Pre Term Birth

By Kyle J. Norton

Women with history of pre mature birth may be benefits from injection of hormone progesterone to reverse the incidence of recurrence, a renowned institute study suggested,

Progesterone is a steroid hormone, produced by the women body to regulate part of the menstrual cycle and supporting the gestation and the process of sperm in egg fertilization.

Preterm birth is a term for any infant born less than 37 weeks gestational age.

According to the joint study lead by the Universitätsklinikum Heidelberg, progesterone has a profound effect in protect the cervix in strengthen the layers of the uterine wall, reduced the myometrial contractility and inhibited the production of pro inflammatory cytokins.

In the review of literature of database from PubMed published from 1956 to August 2014, women with previous preterm birth incidience received vaginal progesterone daily (200 mg capsule or 90 mg containing gel) at from 16+0 to 36+0 weeksm showed a significant improvement in reduced risk of preterm incidence and infant mortality.

The same term of progesterone injected to women with short cervix also benefits in attenuated risk of preterm birth <28, <33, and <35 weeks of gestation.

Unfortunately, progesterone therapy showed inconclusive evidences as maintenance therapy after arrest of preterm labor.

Dr. Kuon RJ, the lead author said, " The vaginal administration of progesterone is well-tolerated by the patients and has only minor maternal side effects".

Other researchers in the finding of pre term incidience suggested that a short cervix may be a clinically silent sonographic in the midtrimester in induced pre term accident. Injection of  vaginal progesterone showed a huge improvement in reduced rate of preterm delivery by 45% as well as the rate of neonatal morbidity.

According to the study, the hormone therapy substantially decrease rate of spontaneous preterm birth with a short cervix in both women with and without a prior history of preterm birth in compared to conventional medicine 17α-Hydroxyprogesterone caproate.

In support to the above analysis, a reviewed analysis of 36 randomised controlled trials (8523 women and 12,515 infants) indicated that progesterone treatment for women with a past history of spontaneous preterm birth showed a statistically significant reduction in the risk of perinatal mortality in compared to placebo, particular in the risk of preterm birth less than 34 weeks' gestation.

In compared to placebo, the study also found that progesterone therapy addressed a significant reduction in the risk of infant birthweight less than 2500 g in other risk factors not related to history and short cervix.

Taking altogether, application of hormone progesterone showed a increadible result in reduced risk of preterm birth between 28  - 34 weeks of gestation in both women with or without previous history of preterm  incidence.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Source

(1) [Progesterone for Prevention of Preterm Birth--Evidence-based Indications]. [Article in German] by Kuon RJ1, Abele H2, Berger R3, Garnier Y4, Maul H5, Schleußner E6, Rath W7; Experts for the Prediction and Prevention of Preterm Birth (X4PB) – www.x4pb.de.(PubMed)
(2) Progesterone to prevent spontaneous preterm birth by Romero R1, Yeo L2, Chaemsaithong P2, Chaiworapongsa T2, Hassan SS2.(PubMed)
(3) Prenatal administration of progesterone for preventing preterm birth in women considered to be at risk of preterm birth by Dodd JM1, Jones L, Flenady V, Cincotta R, Crowther CA.(PubMed)