Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Sunday, 23 July 2017

Herbal Therapy: Andrographis, The Male Contraceptive Whole Herb Medicine?

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes have been predated long before the existence of modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Andrographis paniculata, the forgotten herb showed the ability to influence the male reproductive organ as a contraceptive option contradictively, a renowned institutes study suggested.

Andrographis paniculata, also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, ......

According to the Bharathidasan University, andrographolide, a major chemical constituent of andrographis paniculata affected the process in which spermatozoa are produced from spermatogonial stem cells in the testis by interring the dividing spermatogenic cell lines.

In a 3-month-old male Wistar albino rats at two dose levels, for 48 days, rats fed with andrographolide exerted contraceptive effects by inducing decreased sperm counts, increased in-motile spermatozoa, and several possessed abnormalities.

Dr. Akbarsha MA, the lead research said, "the study points to a male reproductive toxic effect of this compound(andrographolide) when used as a therapeutic".

Unfortunately, also in male Wistar albino rats study, orally administering extract of Andrographis paniculata of 0, 20, 200, and 1000 mg/kg of body weight per day, for 65 days prior to mating and 21 days during mating, treated group showed no effect on testosterone levels and fertility indices and sperm count and sperm motility when compared with the control.

Furthermore, in the comparison of Kan Jang--a fixed combination of Andrographis paniculata special extract (SHA-10) and Acanthopanax senticosus with Valeriana officinalis and Panax ginseng, Kan Jang decode exhibited no significant negative effect of Kan Jang on male semen quality and fertility, but rather a increased number of spermatozoids in the whole ejaculate in compared to others herbal treated group.

The conflict results of above studies may be due to types of research design, small sample size and quality of herbal medicine used....., but regardless to above conclusions, large sample size and mutli centers studies are necessary to resolve these contradiction.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Aspects of the male reproductive toxicity/male antifertility property of andrographolide in albino rats: effect on the testis and the cauda epididymidal spermatozoa by Akbarsha MA1, Murugaian P.(PubMed)
(2) A phase I clinical study of Andrographis paniculata fixed combination Kan Jang versus ginseng and valerian on the semen quality of healthy male subjects by Mkrtchyan A1, Panosyan V, Panossian A, Wikman G, Wagner H.(PubMed)
(3) Reproductive and fertility effects of an extract of Andrographis paniculata in male Wistar rats by Allan JJ1, Pore MP, Deepak M, Murali B, Mayachari AS, Agarwal A.(PubMed)

Saturday, 22 July 2017

Food Therapy: Asparagus, the Whole Food medicine for Reduced Risk of Diabetic Complications and Treatment of Diabetes

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food(herbal medicine) used as medical treatment, linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.
But many researchers have raised question of herbal quality, because geographic differences, time of grown and harvest, etc. may effect their's potency. I do believe, these questions can only be answered by experience herbalists.

Asparagus may be one of best food used to reduced risk of diabetes and diabetic complications of patients with kidney disease.

According to the study by Smt. Kashibai Navale College of Pharmacy, oral administration of ethanolic extract of Asparagus racemosus (EEAR) at a dose level of 100 and 250 mg/kg daily for 4 weeks, significantly reduced the expression of streptozotocin-induced early diabetic nephropathy in compared with control group.

Dr. Somania R, the lead researcher said, " A. racemosus treatment significantly decreased plasma glucose, creatinine, ..... total cholesterol and triglyceride levels. Renal hypertrophy,....and abnormal changes in the renal tissue".

Asparagus is a flowering plant belong to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa and western Asia, used from early times as a vegetable and medicine, because of its delicate flavour and diuretic properties.

Diabetes is a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

In Streptozotocin (90 mg/kg) injected in 2-d-old Wistar rat pups to induce non-obese type 2 diabetes, diabetic rats treated with a methanolic extract of A. officinalis seeds (250 and 500 mg/kg per d) expressed lower fasting blood glucose, improved serum insulin, total antioxidant status and qualitative and quantitative in β-cell function.
These efficacy can be attributed to the extract's anti-diabetic effects by improving insulin secretion and β-cell function.

Furthermore, the asparagus extract also exhibited the hypoglycaemic and hypotriglyceridaemic effects in preventing diabetic complications associated with hyperglycaemia and hyperlipidaemia.

Taking altogether, there is no doubt that many aspects have contributed to the effectiveness of asparagus in reduced risk of diabetic complications and treatment of diabetes, but large amount of asparagus extract intake should only be prescribed by related field specialist

Food Therapy: Kidney Bean, the Best Anti Hperglycemic Whole Food Medicine for Obese and Over Weight Patients

Kidney bean is popular because of its kidney shape, strong flavor and color of reddish brown in nature, It is often an excellent dietary selection with no cholesterol, but a good source of protein and minerals.

According to the University of Extremadura, oral administration of alpha-amylase isolated and purified from an extract of white kidney beans (Phaseolus vulgaris) at 50 mg/kg body weight to adult Wistar rats, ameliorated the increase in glycaemia over the basal value, without modifying the insulin response.

Hyperglycemia is a condition of abnormal high levels of blood sugar, affecting people with type 1 diabetes and type 2 diabetes, as well as pregnant women with gestational diabetes.

Dr. Tormo MA, the lead author said, "(The extract expressed) significant anorexigenic(appetite suppressant) action of the inhibitor; there was reduced food intake...., a reduced weight gain,...., as well as changes in the activity of some intestinal enzymes".

In fact, the extracts of kidney beans ( Phaseolus vulgaris ) reduced glycemia as in studies of rodents and humans may be attributed to the direct interference with the central mechanism(s) in regulating appetite, food intake, and food palatability, inhibited enzymes response to process of starch digestion and hunger.

In genetically obese Zucker fa/fa rats, dry extract administered daily, at doses of 50 and 500 mg/kg, in three 5 days treatment periods followed by three 20 days off-treatment periods, decreased in daily food intake and body weight and suppressed glycaemia in both treatment phases.

The investigation of clinical use of the combination of P. vulgaris and C. scolymus extracts also supported the hypoglycaemic effects of kidney bean as a successful example of translational research in the pharmaceutical-grade and standardized nutrient field.

With the collected information, kidney bean no doubt has processed a clinical value with potential of becoming a standard medicine for treatment in controlling and management of hyperglycemia in obese and over weight patients.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Hypoglycaemic and anorexigenic activities of an alpha-amylase inhibitor from white kidney beans (Phaseolus vulgaris) in Wistar rats by Tormo MA1, Gil-Exojo I, Romero de Tejada A, Campillo JE.(PubMed)
(2) Reducing effect of a Phaseolus vulgaris dry extract on food intake, body weight, and glycemia in rats by Fantini N1, Cabras C, Lobina C, Colombo G, Gessa GL, Riva A, Donzelli F, Morazzoni P, Bombardelli E, Carai MA.(PubMed)
(3) Multiple cycles of repeated treatments with a Phaseolus vulgaris dry extract reduce food intake and body weight in obese rats by Carai MA1, Fantini N, Loi B, Colombo G, Gessa GL, Riva A, Bombardelli E, Morazzoni P.(PubMed)

Friday, 21 July 2017

Food Therapy: Cruciferous Vegetables - The Best Whole Food Medicine for Reduced Risk and Treatment of Colon Cancer

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food(herbal medicine) used as medical treatment, linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.
But many researchers have raised question of herbal quality, because geographic differences, time of grown and harvest, etc. may effect their's potency. I do believe, these questions can only be answered by experience herbalists.

Cruciferous Vegetables containing various phytochemical compounds may be the best vegetables for reduced risk and treatment of colon cancer.
According to the joint study lead by the China Medical University, sulforaphane (SFN), an isothiocyanate, existed only in cruciferous vegetables, interfered the cancer cell cycle division in induction of apoptosis in HCT 116 cells.

Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.

Colon cancer is a condition of the abnormal proliferation of cells in the colon..

Dr. Martin SL the lead author in the study of the effect of sulforaphane (SFN) against colon cancer cells, said, " sulforaphane (SFN), found in cruciferous vegetables such as kale, cabbage and broccoli sprouts, has been present as one of the most potent (histone deacetylase) HDAC inhibitors to date. " and " HDAC inhibition is a promising approach for delaying and/or preventing CRC and may be accomplished via consumption of SFN in cruciferous vegetables".

Futhermore, sulforaphane (SF) also expressed its chemoprotective properties in immortalized human colonic epithelial cell lines with no harm to normal tissues and levels of steroidogenic enzymes which play an important role in the pathogenesis of allergic diseases.

In multiple genetic and signaling pathway alterations underline the development of colon cancer study, 3,3'-diindolylmethane (DIM), a natural compound derived from cruciferous vegetables also significantly suppressed colcon cancer effect through targeting Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation.

According to Dr. Tse G and Dr. Eslick GD. in the address of phytochemicals of Cruciferous Vegetables against colon cancer said, " Evidence shows cruciferous vegetables exhibit chemoprotective properties, commonly attributed to their rich source of isothiocyanates......, cruciferous vegetable intake protects against cancer of the colon" and " (cruciferous vegetable )demonstrates the significance of gene-diet interactions".

Although cruciferous Vegetable has shown to process a potency in treatment of colon cancer, further human trials are necessary to confirm its validation.

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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Sulforaphane Induces Cell Death Through G2/M Phase Arrest and Triggers Apoptosis in HCT 116 Human Colon Cancer Cells by Liu KC1, Shih TY1, Kuo CL2, Ma YS3,4, Yang JL2, Wu PP5, Huang YP6, Lai KC7,8, Chung JG9,10.(PubMed)
(2) Mechanisms for inhibition of colon cancer cells by sulforaphane through epigenetic modulation of microRNA-21 and human telomerase reverse transcriptase (hTERT) down-regulation by Martin SL, Kala R, Tollefsbol TO1.(PubMed)
(3) Sulforaphane Preconditioning Sensitizes Human Colon Cancer Cells towards the Bioreductive Anticancer Prodrug PR-104A by Erzinger MM1, Bovet C1, Hecht KM1, Senger S1, Winiker P1, Sobotzki N2, Cristea S3,4, Beerenwinkel N3,4, Shay JW5, Marra G6, Wollscheid B1,2,7, Sturla SJ1.(PubMed)
(4) Genome-wide transcriptome analysis reveals inactivation of Wnt/β-catenin by 3,3'-diindolylmethane inhibiting proliferation of colon cancer cells by Leem SH1, Li XJ2, Park MH3, Park BH4, Kim SM2.(PubMed)
(5) Cruciferous vegetables and risk of colorectal neoplasms: a systematic review and meta-analysis by Tse G1, Eslick GD.(PubMed)

Food Therapy: Cruciferous Vegetables, the Best Anti Chemical Carcinogens Whole Food Medicine

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food(herbal medicine) used as medical treatment, linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.
But many researchers have raised question of herbal quality, because geographic differences, time of grown and harvest, etc. may effect their's potency. I do believe, these questions can only be answered by experience herbalists.

Cruciferous vegetables with rich of phytochemcals may be the food for reduced risk and treatment of
chemical carcinogens

According to the Universidade Federal de Ouro Preto, sulforaphane (SFN),the isothiocyanate (ITC) group of organosulfur compounds found in cruciferous vegetable expressed chemopreventive properties involved in detoxification processes of chemical carcinogens.

Dr. de Figueiredo SM, the lead author said, " In a dose dependent manner, ITC inhibits the viability of human cancer cells, modifies epigenetic events that occur in cancer cells and present antiinflammatory effect acting during the initial of uncontrolled cell proliferation."

Chemical carcinogens are types of cancer caused by chemical toxins in induction of cellular and chromosomes change, DNA damage, etc.

The chemoprotective activity of the vegetable is the result of the significant expression of the antioxidants in cell cycle arrest and apoptosis in cancer cells as well as acting as the post-initiation stages of carcinogenesis, as a 'suppressing' agent involving the ability to modulate the Nrf2 in reduced damage from oxidative damage.

In fact, beside use as chemopreventive agent against chemical carcinogenesis, sulforaphane (SFN),the major chemical constituent of cruciferous vegetables also inhibited the drug-metabolizing enzymes that cause activation/neutralization of carcinogenic metabolites and protecting normal healthy cells from environmental toxin induced of cancers.

Furthermore, the phytochemical exhibited the molecular mechanisms responsible for the overall chemopreventive effects on selective cytotoxicity, in reduced oxidate stress, free radicals produced by lipid peroxidation in cells.

In the study of tobacco smoke carcinogens induced chemical tumors, cruciferous vegetable consumption has shown to inversely associate the development of cancer. In animal experiments. the chemopreventive effects of isothiocyanates, another compound found cruciferous vegetable, inhibited the metabolic activation of carcinogens by cytochrome P450s, enzymes with function in metabolized potentially toxic compounds.

Taking together, intake of cruciferous vegetables have a potential health benefits against environment toxins in cancer development, but due to small size of the sample, further studies are necessary to address its viability.

Thursday, 20 July 2017

Herbal Therapy: Aloe Vera, The Whole Food Medicine Enhanced Male Reproductive Parameters

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

People who turn to alternative medicine for treatment of any disease in avoidance of adverse side effects induced by conventional medicine should be patient.
If you expect that herbal medicine will ease the symptoms of your illness immediately, you will be disappointed. Herbal medicine can only ease symptoms gradually, depending to stage of the treatment which directly address to the cause of disease.

Oral administration of whole food Aloe Vera showed to improve male reproductive parameters.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to enormous health benefits. Aloe vera has also been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, anhe d elevated of cholesterol, etc.

Whole-body X-ray irradiation-induced testicular alterations in mice is associated to Male Reproductive dysfunction.
Pretreatment of Aloe vera extract promoted sperm count/motility and testosterone levels significantly through reduced elevation in the levels of reactive oxygen species, lipid peroxidation, and improved oxidant enzymes, according to the joint study lead by the Panjab University.

Dr. Bala S, the lead author said, "Irradiated animals pre-treated with A. vera extract revealed an improvement in antioxidant status, inhibition of lipid peroxides, apoptotic cell formation and enhanced testicular parameters when compared to the X-ray-exposed group".

In a total of participants of 49(36 women, 13 men; 31 ± 10.3 years of age) recruited from the faculty, staff, students, and community members from a chiropractic college to participate in a 21-day weight loss program, pre treatment of cleanse supplementation included Aloe Vera induced weight loss and improved total cholesterol and low-density lipoprotein cholesterol levels and increased in testosterone for men.

Furthermore, oral administration of graded doses (100, 200 and 400 mg/kg) of ethanol extract of Aloe. barbadensis root in rat study, significantly increased mounting and intromission frequency, testosterone and cholesterol concentrations with the best aphrodisiac effects showed in lowest dose of 100 mg/kg.

The study also addressed, the ethanol extract may be used to treat hypotestosteronemia because of its ability to increase testosterone without inducing adverse effect of toxicity.

Taking together, Aloe Vera may have a potential effect in exhibited male reproductive parameters, but more precised understanding of the biological activities is necessary.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Aphrodisiac potentials of the ethanol extract of Aloe barbadensis Mill. root in male Wistar rats by Erhabor JO1,2, Idu M3.(PubMed)
(2) Changes in anthropometric measurements, body composition, blood pressure, lipid profile, and testosterone in patients participating in a low-energy dietary intervention by Balliett M1, Burke JR.(PubMed)
(3) Protective role of Aloe vera against X-ray induced testicular dysfunction by Bala S1, Chugh NA1, Bansal SC2, Garg ML1, Koul A3.(PubMed)

Food Therapy: Celery, the Natural Whole Food with Analgesic effects

Celery may be used as analgesic agent in treating chronic musculoskeletal pain.

Recent study suggested that celery used conjunction with other herbs, such as Urtica dioica (stinging nettle), Boswellia serrata, Equisetum arvense, and Apium graveolens expressed the pain relief which impacts the motion and mobility at each location with pain. in patient of persistent musculoskeletal pain for at least 4 months.

Dr. Hedaya R. the author in the study said, " (the five herbs and vitamin B1)(showed a) clinically significant reduction in perceived pain and improvement in functional mobility.... for the intervention group as related to their chronic joint, back, and muscle pain".

Celery is a species of Apium graveolens, belonging to the family Apiaceae, cultivated all around the globe as a vegetable. Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

Celery Seed Extract (CSE), in comparison to conventional medicine, aspirin, ibuprofen, and naproxen in suppressing pain in arthritis exerted more efficient result in ameliorated existing inflammation and exhibited analgesic effect in test animals.

The study also suggested that in analgesic effects, the extract does affect the p450 enzyme systems
in metabolism as well as altering the metabolism of drugs which the individual may be taking.

In Ulcers induced by indomethacin, cytodestructive agents (80% ethanol, 0.2 M NaOH and 25% NaCl) and cold restraint stress, celery extract expressed its antioxidant property in protection of the decrease levels of gastric wall mucus(GWM) and suppressed the basal gastric secretion with no toxic symptoms.

Taking together, there is no doubt that celery processed an analgesic effect in reduced pain causes by induction of proinflammatory cytokins through its antioxidant activities. In take of herbal product, instead of whole food celery should be taken with care.