Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Thursday, 6 July 2017

Herbal Therapy: Chamomile, the Natural Whole Herb Medicine for Reduced Risk and Treatment of Gastric Ulcers

Scientists from the respectable institution may have found an ingredient from herbal chamomile for treatment of Gastric ulcers with little or no side effects.

According to the King Khalid University, in ethanol induced Gastric ulcers, Chamomilla recutita (ACE), exhibited the expression of antioxidant glutathione in regulation of the herbal mediated effect on gastric ulcer.

Dr. Al-Hashem FH, the author of the study, said," Compared to non-ACE treated rats, the ulcer index (UI) decreased significantly in a dose-dependent manner in treated animals" and " glutathione(GSH) levels fell significantly after ethanol treatment; this decrease was prevented by ACE treatment".

Gastric ulcer, a type of peptic ulcer is a condition of a localized tissue erosion in the lining the stomach, inducing symptoms of abdominal pain, bloating, septic shock, Dyspepsia, Blood in stool, bleeding, etc.

Chamomile is also known as camomile, common name of many species daisy-like plants in the family Asteraceae, used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.

The herbal medicine Alpha-bisabolol, a bioactive component, in animal study also inhibited gastric mucosal damage. Oral doses of 50 and 100 mg=kg markedly attenuated the gastric lesions induced by ethanol to the extent of 87% and 96% in activation of cellular metabolism.

Furthermore, the commercial preparation (STW 5, Iberogast), containing the extracts of bitter candy tuft, lemon balm leaf, chamomileflower, caraway fruit, peppermint leaf, liquorice root, Angelica root, milk thistle fruit and greater celandine herb, tested in patients with gastric ulcer, not only lower the gastric acidity, but also inhibited the secondary hyperacidity.

In ethanol-induced acute gastric mucosal injury in rats, Matricaria chamomilla L. (Compositae) hydroalcoholic extract (MCE) exerted a protective effect against ethanol-induced gastric mucosal lesions, depending upon the reduction in lipid peroxidation and augmentation in antioxidant activity. Dr. Cemek M, the lead researcher at the Afyon Kocatepe University suggested.

There is no doubt that chamomile and combination of chamomile with other herbal medicines are found to express gastrointestinal effects in reduced risk and treatment of gastric ulcer. But effective doses should only be prescribed by herbalist to prevent toxicity.

Wednesday, 5 July 2017

Herbal Therapy: Cayenne, The Best Whole Herb Medicine for Prevention and Treatment of Liver Cancer

Capsaicin (8-methyl-N-vanillyl-6-nonenamide), a major ingredient found in cayenne may be used as supplement for protection against liver cancer.
According to recent study by the Duksung Women's University, oral administration of Capsaicin inhibited HepG2 human hepatoblastoma cells, through its antioxidants activities in induction of apoptosis in oxidase-mediated generation of ROS.

Other studies insisted that cayenne, exerted protection against liver cancer, is the result of inhibition of cancer cells proliferation, migration and invasion of tumors, and induced tumors to radiotherapy and chemotherapy.

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions, used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises and neuralgia, etc.

Liver cancer is a condition of out of controlled growth of hepatocellular cells in the liver. Since the organ is a soft tissue with less nerve, most liver cancer patient are diagnosed in the later stage of the cancer. According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

In a 4-wk feeding of B6C3F1 mice at 6 wk of age, oral intake of cayenne group expressed not only body weight but also reduced hypoglycemia and cells involved generation of liver cancer.

Dr. Teel RW, autheor of the research said, " At concentrations of 25, 50, and 100 microM, capsaicin inhibited the biotransformation of (Aflatoxin B1(AFB1) produced by hepatitis viral) by modifying Phase I hepatic enzyme activity ( induced damage and injure of liver) "

Furthermore, in the inhibition of toxical metabolism, capsaicin also possessed antimutagenic and anticarcinogenic properties against many types of cancer.

Taking altogether, cayenne may process the anti liver cancer effect, but large quantity intake should only be prescribed by herbalists.

Herbal Therapy: Cinnamon: The Best Immunomodulatory Whole food Medicine

Intake of cinnamon may induce immunomodulatory effect in regular immune function against certain diseases such as auto immunity. According to the Kyung Hee University, water extract of cinnamon bark (CWE) exerted the effect on cytokine secretion and activation of T cells.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections.

Sodium benzoate (NaB), a metabolite of cinnamon ameliorated clinical symptoms and disease progression of allergic encephalomyelitis caused by immune over reaction induced inflammation, through enriched regulatory T cell population, and down-regulated the expression of various contact molecules in T cells.

Dr. Pahan K said, "Sodium benzoate (NaB), a metabolite of cinnamon and a FDA-approved drug against urea cycle disorders in children, ......, regulates many immune signaling pathways responsible for inflammation, glial cell activation, switching of T-helper cells, modulation of regulatory T cells, cell-to-cell contact, and migration"

Orofacial granulomatosis (OFG) is a chronic inflammatory disorder with symptoms of inflammation such as lip swelling but also affecting gingivae, buccal mucosa, floor of mouth,.....
cinnamon- and benzoate-free diet, after 8 weeks of treatment, significantly improve both lips and oral site.

Furthermore, experiment of cinnamon (Cinnamomum zeylanicum) bark essential oil (CBEO) on human skin cells showed strong anti-proliferative effects on skin cells and significantly inhibited the production of several inflammatory biomarkers expressed by auto immunity.

Cinnamon may improve immune expression and reduce risk of auto immune diseases, intake of the whole herb should be taken with care in prevention of toxicity

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Immunomodulatory effect of water extract of cinnamon on anti-CD3-induced cytokine responses and p38, JNK, ERK1/2, and STAT4 activation by Lee BJ1, Kim YJ, Cho DH, Sohn NW, Kang H.(PubMed)
(2) Immunomodulation of experimental allergic encephalomyelitis by cinnamon metabolite sodium benzoate by Pahan K1.(PubMed)
(3) Sodium benzoate, a food additive and a metabolite of cinnamon, modifies T cells at multiple steps and inhibits adoptive transfer of experimental allergic encephalomyelitis by Brahmachari S1, Pahan K.(PubMed)
(4) Improvement in orofacial granulomatosis on a cinnamon- and benzoate-free diet by White A1, Nunes C, Escudier M, Lomer MC, Barnard K, Shirlaw P, Challacombe SJ, Sanderson JD.(PubMed)

Tuesday, 4 July 2017

Herbal Therapy: Cayenne, the Natural Whole Herb for Antimicrobial Infection

Cayenne may be the next antimntimicrobial natural whole foods used for prevention and treatment of infection, inflammation and common cold.

According to the joint study lead by the Universidad Michoacana de San Nicolás de Hidalgo, cayenne exhibited a broad-spectrum antimicrobial action, through its' immunomodulatory roles of mammal β-defensins(antimicrobial peptides) in regulated inflammation and activated the immune system.

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises and neuralgia, etc.

Thionins, a chemical compound found in cayenne is considered as an antimicrobial peptides (AMPs), which regulate plant defense system against pathogens. such as Candida species, with IC50 ranging from 10 to 40 μg.mL(-1).
The chemical compound also exhibited anti antimicrobial effect through its antioxidant activity against oxidative stresses. In bacteria and yeasts induced infection and inflammatory diseases, it exhibited toxicity and induced changes in the membranes of all yeast strains, leading to their permeabilization..

Dr. Diz MS, the lead author in the study peptides from chili pepper seeds, said, " F1(peptides from chili pepper (Capsicum annuum L.) seeds) fraction exhibited strong fungicidal activity against Candida albicans, Saccharomyces cerevisiae and Schizosaccharomyces pombe and also promoted several morphological changes to C. albicans".

In some yeast species, peptides isolated from cayenne also inhibited the growth of yeasts Saccharomyces cerevisiae, Candida albicans, Candida parapsilosis, Candida tropicalis, Pichia membranifaciens,

Intake of cayenne may improve the immunomodulatory activity in the body against microbial organisms induced infection and inflammation, but quantity intake should only be given by herbalist for prevention of overdoses' toxicity.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Defensin γ-thionin from Capsicum chinense has immunomodulatory effects on bovine mammary epithelial cells during Staphylococcus aureus internalization by Díaz-Murillo V1, Medina-Estrada I1, López-Meza JE1, Ochoa-Zarzosa A2.(PubMed)
(2) Thionin-like peptide from Capsicum annuum fruits: mechanism of action and synergism with fluconazole against Candida species by Taveira GB1, Carvalho AO2, Rodrigues R3, Trindade FG4, Da Cunha M5, Gomes VM6(PubMed)
(3) Thionin-like peptides from Capsicum annuum fruits with high activity against human pathogenic bacteria and yeasts by Taveira GB1, Mathias LS, da Motta OV, Machado OL, Rodrigues R, Carvalho AO, Teixeira-Ferreira A, Perales J, Vasconcelos IM, Gomes VM.(PubMed)
(4) Antimicrobial peptides from chili pepper seeds causes yeast plasma membrane permeabilization and inhibits the acidification of the medium by yeast cells by Diz MS1, Carvalho AO, Rodrigues R, Neves-Ferreira AG, Da Cunha M, Alves EW, Okorokova-Façanha AL, Oliveira MA, Perales J, Machado OL, Gomes VM.(PubMed)

Food Therapy: Whole Food Garlic for Reduced Risk and Treatment of Hypertension

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food(herbal medicine), linking health benefits in prevention, management and treatment of diseases has placed an important role in human history over many centuries. The finding of whole food medication by renowned scientists all over world to replace the single ingredient of Western medicine with little or no side effect has been difficult due to no commercial benefit and patent right to producers.

Garlic may be used as chemo preventive and treatment agent against hypertension. In hypertension of 80-90% patients with excess glucocorticoid level, allicin found in garlic attenuated dexamethasone-induced anorexia and loss of total body weight.

Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. High blood pressure means raising pressure in your heart.If it stays high over time it can damage the body in many ways.

Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects such as damaging the kidney. If you can control your diet, such as making changes to lifestyle, maintaining ideal weight and diet with low salt, you could do just fine without the drugs.

In an adult men and women, participated in the Tehran Lipid and Glucose Study (2006-2008 to 2012-2014), intake of garlic is associated to reduce risk of hypertension by up 26%.

In support of the above, a randomized, placebo-controlled, clinical trial conducted on 56 CAD patients, aged 25 - 75 years old also suggested that treatment with garlic-based drugs can be an effective treatment for controlling BP in CAD patients and has no interaction with other drugs that CAD patients take, after 3 months of administration.

Dr. Takashima M the lead author at the Wakunaga Pharmaceutical Co. Ltd said, " aged garlic extract (AGE) is effective in reducing blood pressure of hypertensive patients,......AGE induced the concentration-dependent vasorelaxation of isolated rat aortic rings that had been precontracted with norepinephrine"

In fact, Traditional Chinese Medicine, Food Therapy, and Hypertension Control, garlic is of the food recommended to be used to facilitate hypertension control. Based on a statistical analysis of antihypertensive foods recommended in 20 books on the application of food therapy for hypertension control.

Taking altogether, garlic may be used as preventive and controlling effects for patients with or without high blood pressure. Some researchers insisted that garlic anti hypertension effect may be resulted of its anticoagulant property.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats by Dubey H1,2, Singh A1, Patole AM2, Tenpe CR2(PubMed)
(2) Allium vegetable intakes and the incidence of cardiovascular disease, hypertension, chronic kidney disease, and type 2 diabetes in adults: a longitudinal follow-up study by Bahadoran Z1, Mirmiran P, Momenan AA, Azizi F.(PubMed)
(3) Does Garlic Supplementation Control Blood Pressure in Patients with Severe Coronary Artery Disease? A Clinical Trial Study by Mahdavi-Roshan M1, Nasrollahzadeh J1, Mohammad Zadeh A2, Zahedmehr A3.(PubMed)
(4) Traditional Chinese Medicine, Food Therapy, and Hypertension Control: A Narrative Review of Chinese Literature by Zou P1(PubMed)
(5) The anticoagulant rivaroxaban lowers portal hypertension in cirrhotic rats mainly by deactivating hepatic stellate cells by Vilaseca M1,2, García-Calderó H1,3, Lafoz E1,2, García-Irigoyen O3,4, Avila MA3,4, Reverter JC5, Bosch J1,2,3,6, Hernández-Gea V1,3, Gracia-Sancho J1,2,3, García-Pagán JC1,2,3(PubMed)

Monday, 3 July 2017

Herbal Therapy: Chamomile, The Whole Herb medicine for Wound Healing

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food(herbal medicine) used as medical treatment, linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.

But many researchers have raised question of herbal quality, because geographic differences, time of grown and harvest, etc. may effect their's potency. I do believe, these questions can only be answered by experience herbalists.

Herbal chamomile expressed significantly wound healing effect against injure and bacterial invasion induced more damage to the wound.
According to the Shiraz University of Medical Sciences, C. nobile therapy at 5% C. nobile ointment was an effective antibacterial activity and accelerated the progression of wound healing, in vivo.

Chamomile is also known as camomile, common name of many species daisy-like plants in the family Asteraceae, used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.

Wound healing is a natural stage of recover of body injure.

In a Wistar male rats (210.0±4.2 g) divided into five groups: negative control group (NCG) without diabetes; positive control group (PCG) with DM (alloxan, 45 mg/kg) study, groups treated with chamomile extract optimize the healing of traumatic oral ulcers in diabetic rats through the reduction of apoptosis in regulated immune system.

The review of skin wound healing of phytomedicine, Dr. Pazyar N, the lead author said, " The healing process proceeds in four phases: hemostasis, inflammation, proliferation and remodeling" and " Phytomedicine presents remedies, which possess significant pharmacological effects. It is popular amongst the general population in regions all over the world. Phytotherapeutic agents have been largely used for cutaneous wound healing.....(included chamomile".

The Roskilde Universitet, in the support of the wound healing effect of chamomile suggested the extract of M. chamomilla administered topically has wound healing potential in linear incisional wound, according to animal study.

Other studies also showed that chamomile proved effective in the treatment of oral mucositis in a hamster model.

Taking altogether, chamomile no doubt has consisted a significant wound healing effects by exhibited the increased wound-breaking strength, protein collage content through topical administration.

However, well-designed clinical studies are needed to confirm the clinical efficacy of this medicine in humans.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) In vivo antibacterial and wound healing activities of Roman chamomile (Chamaemelum nobile). by Kazemian H, Ghafourian S, Sadeghifard N, Badakhsh B, Heidari H1, Taji A, Shavalipour A, Mohebi R, Ebrahim-Saraie HS, Houri H, Houshmandfar R.(PubMed)
(2) TNF-alpha expression, evaluation of collagen, and TUNEL of Matricaria recutita L. extract and triamcinolone on oral ulcer in diabetic rats by Oliveira BV1, Barros Silva PG1, Nojosa Jde S2, Brizeno LA3, Ferreira JM4, Sousa FB1, Mota MR1, Alves AP1.(PubMed)
(3) Skin wound healing and phytomedicine: a review by Pazyar N1, Yaghoobi R, Rafiee E, Mehrabian A, Feily A.(PubMed)
(4) Evaluation of topical Matricaria chamomilla extract activity on linear incisional wound healing in albino rats by Jarrahi M1, Vafaei AA, Taherian AA, Miladi H, Rashidi Pour A.(PubMed)
(5) Healing action of topical chamomile on 5-fluoracil induced oral mucositis in hamster by Pavesi VC1, Lopez TC, Martins MA, Sant'Ana Filho M, Bussadori SK, Fernandes KP, Mesquita-Ferrari RA, Martins MD.(PubMed)

Herbal Therapy: Cat's Claw, the Best Whole Herb medicine for Prevention and Treatment of Colorectal cancer

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food(herbal medicine) used as medical treatment, linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.

Many researchers has raised question of quality of the herbs because geographic differences, time of grown and harvest, etc. may effect their's potency. I do believe, these questions can only be answered by experience herbalists.

Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..

The chemical constituents of Cat's claw include, ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.

Bowel cancer also known as colorectal cancer, is a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. Bowl is divided in 2 parts, the first part of the bowel, the small bowl, is involved with the digestion and absorption of food. The 2nd part, the large bowel which consist the the colon and rectum, is involved in absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be re absorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progress cancer and in predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including U>S and Canada.

Cat's Claw extract may have a role for cancer patients as a complementary therapy. According to the joint study lead by the Federal University of Santa Maria (UFSM), Cat's Claw enhanced chemotherapy-induced apoptosis, with an interference in cell cycle division in colorectal adenocarcinoma cells (HT29 cells).

Dr. Gurrola-Díaz CM, the lead researchers at the Centro Universitario de Ciencias de la Salud (CUCS) suggested, the anti-inflammatory and anti-proliferative properties of different alkaloids extracted from Cat's Claw may be resulted of the interfering the proteins that pass signals into a cell through cell surface receptors. Uncaria tomentosa is less toxic in non-cancer cells than in cancer cells.

In a randomized clinical trial conducted of Patients (43) undergoing adjuvant/palliative chemotherapy, patient received chemotherapy plus 300 mg of Uncaria tomentosa daily, showed to reduce side effects of chemotherapy with no toxic effect.

Dr. Valerio LG Jr and Dr. Gonzales GF. in the review of the toxicological aspects of the South American herbs cat's claw said, " An important finding unveiled by this review is the importance of standardisation in quality and additional basic and clinical research to scientifically validate and understand composition, biological activity, safety and risk" and " Development of a comprehensive pharmacological and toxicological profile through critical evaluation of existing and future experimental data... "

Therefore, the use of Cat's Claw as a whole herb medicine should be taken with care. The quantity intake can only be prescribed by professional; herbalists.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis by Nogueira Neto J1, Cavalcante FL, Carvalho RA, Rodrigues TG, Xavier MS, Furtado PG, Schor E.(PubMed)
(2) Inhibitory mechanisms of two Uncaria tomentosa extracts affecting the Wnt-signaling pathway by Gurrola-Díaz CM1, García-López PM, Gulewicz K, Pilarski R, Dihlmann S.(PubMed)
(3) Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial by Farias IL1, Araújo MC, Farias JG, Rossato LV, Elsenbach LI, Dalmora SL, Flores NM, Durigon M, Cruz IB, Morsch VM, Schetinger MR.(PubMed)
(4) Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis by Valerio LG Jr1, Gonzales GF.(PubMed)