Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Treatment of Dementia Induced by Heart (Yang) Qi deficiency - Herbal Dan shen
Based on Chinese ancient medical records, causes of dementia are the results of (*)
B.1. Deficiency of Qi, mainly due to
B.2. Heart (Yang) Qi deficiency
Heart Qi deficiency is a condition of the inability of the heart in transportation of nutrients to body organs, including the brain through blood circulation. Prolong period of malnutrition of brain cells may induce abnormal function of brain's cells in information transmitting or death of neurons, causing cognitive impairment(844), including learning and memory deficits(842), changes in brain tissue and behavior patterns(843)(842).
1. Dan shen
Dan Shen is also known as Red Sage Root with taste of the bitter and slightly cold in nature, used in TCM as antithrombotic(845), antihypertonic (lowering blood pressure)(846), antimicrobial(847), anti-inflammatory(848)(849), agents and to treat coronary and cerebrovascular disease, dysmenorrhea, amenorrhea, hepatitis, hepatocirrhosis, restlessness, insomnia, irritability,(850) etc., by enhancing the functions of heart and liver channels.
Phytochemicals
1. Cryptotanshinone
2. Hydroxytanshinone,
3. Methyltanshinonate
4. Methylene tanshiquinone
5. Przewatanshinquinone A
6. Przewatanshinquinone B
7. Miltirone
8. Dihydrotanshinone I
9. Tanshinol A
10. Tanshinol B
11. Tanshinol C,
12. Nortanshinone
13. 1, 2, 15, 16-tetrahydrotanshiquinone
14. Danshensuan A, B, C
15. Protocatechuic acid,
16. Protocatechuic aldehyde
17. Etc.
1.1. Dementia
According to Mashhad University of Medical Sciences, dan shen in the pharmacological effects on the central nervous system, showed to exert its neuroprotective activity through antiparkinsonian, relaxant, analgesic and memory enhancing(850). In PC12 cells, combination application of salvianolic acid B (Sal B) and Ginkgo biloba extract EGb 761, effectively inhibited the formation of amyloid fibrils and protected PC12 cells(855) from beta-AP25-35-induced cytotoxicity and ROS accumulation(854).
1.2. Alzheimer's disease (AD)
Simple poly hydroxycinnamic acids and diterpenoid quinone, found in dan shen improved cognitive deficits in mice model, through protection of neuronal cells, prevention of amyloid fibril formation and preformed amyloid fibril disaggregation related to Alzheimer's disease(851). Salvianolic acid B (Sal B)isolated from dan shen, in animal model, not only prevented Abeta-induced cytotoxicity(857) but also improved cognitive deficits and protection of neuronal cells(852), through its effects on suppressing the production of ROS, calcium flux, and apoptosis(853), promoted amyloid precursor protein (APP) metabolism toward the non-amyloidogenic products pathway in cortical neuronal cell(856) and multifunctional machenisms(857). Compound Danshen Tablets (CDST), in rat model, exhibited spatial cognitive protection through decreased beta-APP expression in the cortex and hippocampus, detected via immunohistochemistry(859).
1.3. In learning and memory impairment
In diabetic rats model, dan shen injection improved the learning and memory decline, through upregulation of expression of MKP-1 in reduced inflammation(861) and hyperglycemia(860). HX106N, a Chimese herbal formula, containing dan shen, in Aβ25-35 peptide mice, enhanced on memory impairment and oxidative stress through increased levels of heme oxygenase-1 (HO-1)(862). In a joint study of renowned institutions, in mouse model, myelophil, a combination of extracts taken from Astragali Radix and Salviae Miltiorrhizae Radix, significantly exhibited its anti-amnesic properties in memory impairment, through the modulation of cholinergic activity(863). Tanshinones, a group of diterpenoids found in dan shen, also improved learning and memory impairments, through its inhibitory effect on acetylcholinesterase(864)
1.4. In neuroprotective effects
Tanshinone IIA (Tan IIA), one of the major active constituents of dan shen exerted its neuroprotective effects, by inhibiting transcription and translation of genes involved AD development(858). In neurotoxicity of β-amyloid protein (Aβ), contributed Alzheimer's disease (AD), dan shen extract suppressed the increased intracellular reactive oxygen species levels, through deduction of decreased the protein expression involved in the development of neurodegenerative disease, including ADs(865). According to Eur J Pharmacol and University of Sydney, salvianolic acid B (SalB) found in dan shen, in mouse model, exhibited neuroprotective effects in an amyloid β (Aβ) peptide-induced Alzheimer's disease, through its anti-inflammatory, anti-oxidative effects(866) and ameliorated cholinergic dysfunction- or Aβ(25-35)-induced memory impairment(867), respectively.
Herbal medicine for Heart Qi deficiency
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(*) Traditional Chinese Medicine for Senile Dementia by Zhihong Lin,1 Jie Gu,1 Jin Xiu,1 Tingyan Mi,1 Jie Dong,1 and Jyoti Kumar Tiwari2(Hindawi)
(842) Folate deficiency in rat pups during weaning causes learning and memory deficits. by Berrocal-Zaragoza MI1, Sequeira JM1, Murphy MM2, Fernandez-Ballart JD2, Abdel Baki SG3, Bergold PJ3, Quadros EV1.(PubMed)
(843) Changes in brain tissue and behavior patterns induced by single short-term fasting in mice. by Hisatomi Y1, Asakura K, Kugino K, Kurokawa M, Asakura T, Nakata K.(PubMed)
(844) Combined low calcium and lack magnesium is a risk factor for motor deficit in mice. by Taniguchi R1, Nakagawasai O, Tan-no K, Yamadera F, Nemoto W, Sato S, Yaoita F, Tadano T.(PubMed)
(845) Antiplatelet and antithrombotic activities of salvianolic acid A by Fan HY1, Fu FH, Yang MY, Xu H, Zhang AH, Liu K.(PubMed)
(846) The anti-hypertensive effect of Danshen (Salvia miltiorrhiza) and Gegen (Pueraria lobata) formula in rats and its underlying mechanisms of vasorelaxation. byb Ng CF1, Koon CM, Cheung DW, Lam MY, Leung PC, Lau CB, Fung KP.(PubMed)
(847) [Roles of reactive oxygen species in Streptomyces pactum Act12-induced tanshinone production in Salvia miltiorrhiza hairy roots].[Article in Chinese] by Yan Y, Zhao X, Zhang SC, Liu Y, Liang ZS.(PubMed)
(848) [Clinical observation of treating 62 patients with severe aplastic anemia failing in immunosuppressive therapy by integrative medicine].[Article in Chinese] by Su EY1, Fang YH, Chen HS.(PubMed)
(849) Anti-Inflammatory and Immunomodulatory Mechanism of Tanshinone IIA for Atherosclerosis. by Chen Z1, Xu H2.(PubMed)
(850) The pharmacological effects of Salvia species on the central nervous system by Imanshahidi M1, Hosseinzadeh H.(PubMed)
(851) Danshen diversity defeating dementia by Hügel HM1, Jackson N2.(PubMed)
(852) Salvianolic acid B inhibits Abeta fibril formation and disaggregates preformed fibrils and protects against Abeta-induced cytotoxicty. by Durairajan SS1, Yuan Q, Xie L, Chan WS, Kum WF, Koo I, Liu C, Song Y, Huang JD, Klein WL, Li M.(PubMed)
(853) [Comparison of the inhibitory activities of salvianolic acid B and Ginkgo biloba extract EGb 761 on neurotoxicity of beta-amyloid peptide].[Article in Chinese] by Liu CS1, Hu JF, Chen NH, Zhang JT.(PubMed)
(854) [Comparison of the inhibitory activities of salvianolic acid B and Ginkgo biloba extract EGb 761 on neurotoxicity of beta-amyloid peptide].[Article in Chinese] by Liu CS1, Hu JF, Chen NH, Zhang JT.(PubMed)
(855) Tanshinone IIA protects PC12 cells from β-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway. by Dong H1, Mao S, Wei J, Liu B, Zhang Z, Zhang Q, Yan M.(PubMed)
(856) Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro by Mei Z1, Zhang F, Tao L, Zheng W, Cao Y, Wang Z, Tang S, Le K, Chen S, Pi R, Liu P.(PubMed)
(857) Salvianolic acid A, a polyphenolic derivative from Salvia miltiorrhiza bunge, as a multifunctional agent for the treatment of Alzheimer's disease. by Cao YY1, Wang L, Ge H, Lu XL, Pei Z, Gu Q, Xu J.(PubMed)
(858) Tanshinone IIA reduces the risk of Alzheimer's disease by inhibiting iNOS, MMP‑2 and NF‑κBp65 transcription and translation in the temporal lobes of rat models of Alzheimer's disease. by Jiang P1, Li C1, Xiang Z2, Jiao B2.(PubMed)
(859) Effects of compound danshen tablets on spatial cognition and expression of brain beta-amyloid precursor protein in a rat model of Alzheimer's disease by Qin RA1, Yao XX, Huang ZY.(PubMed)
(860) Protective effects of Salvia miltiorrhiza injection against learning and memory impairments in streptozotocin-induced diabetic rats by Cai H1, Lian L2, Wang Y2, Yu Y2, Liu W2.(PubMed)
(861) Targeting mitogen-activated protein kinase phosphatase-1 (MKP-1): structure-based design of MKP-1 inhibitors and upregulators by Doddareddy MR1, Rawling T, Ammit AJ.(PubMed)
(862) Ameliorating effects of HX106N, a water-soluble botanical formulation, on Aβ25-35-induced memory impairment and oxidative stress in mice. by Lee DS1, Choi J, Kim SH, Kim S.(PubMed)
(863) Ethanol extract of Astragali Radix and Salviae Miltiorrhizae Radix, Myelophil, exerts anti-amnesic effect in a mouse model of scopolamine-induced memory deficits. by Lee JS1, Kim HG1, Han JM1, Kim DW2, Yi MH2, Son SW3, Kim YA1, Lee JS4, Choi MK1, Son CG5.(PubMed)
(864) Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice by Kim DH1, Jeon SJ, Jung JW, Lee S, Yoon BH, Shin BY, Son KH, Cheong JH, Kim YS, Kang SS, Ko KH, Ryu JH.(PubMed)
(865) Neuroprotection against Aβ25-35-induced apoptosis by Salvia miltiorrhiza extract in SH-SY5Y cells by Yu H1, Yao L2, Zhou H3, Qu S1, Zeng X1, Zhou D1, Zhou Y1, Li X1, Liu Z4.(PubMed)
(866) Neuroprotective effects of salvianolic acid B on an Aβ25-35 peptide-induced mouse model of Alzheimer's disease. by Lee YW1, Kim DH, Jeon SJ, Park SJ, Kim JM, Jung JM, Lee HE, Bae SG, Oh HK, Son KH, Ryu JH.(PubMed)
(867) Cognitive dysfunctions induced by a cholinergic blockade and Aβ 25-35 peptide are attenuated by salvianolic acid B by Kim DH1, Park SJ, Kim JM, Jeon SJ, Kim DH, Cho YW, Son KH, Lee HJ, Moon JH, Cheong JH, Ko KH, Ryu JH.(PubMed)
Friday, 10 February 2017
Thursday, 9 February 2017
The holistic Prevention, Management and Treatment of Dementia : TCM Treatment due to Kidney Qi Deficiency
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Treatment of Dementia Induced by Kidney Qi Deficiency
Based on Chinese ancient medical records, causes of dementia are the results of (*)
B.1. Deficiency of Qi, mainly due to
B.1.1. Kidney Qi deficiency
Kidney Qi deficiency is a condition of the inability of kidney in expelling extra fluid in the body through urinary secretion via bladder. If the fluid accumulation(a) or hydration(b) occurs in the brain(a) for a prolong period of time, can induce abnormal function of neurons in information transmitting or gradual death of brain's neurons(c), leading cognitive impairment, including dementia. In elders, kidney Qi deficiency may also be related to gradual depletion of kidney essences(Jing) due to aging, according to traditional Chinese medicine.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Treatment of Dementia Induced by Kidney Qi Deficiency
Based on Chinese ancient medical records, causes of dementia are the results of (*)
B.1. Deficiency of Qi, mainly due to
B.1.1. Kidney Qi deficiency
Kidney Qi deficiency is a condition of the inability of kidney in expelling extra fluid in the body through urinary secretion via bladder. If the fluid accumulation(a) or hydration(b) occurs in the brain(a) for a prolong period of time, can induce abnormal function of neurons in information transmitting or gradual death of brain's neurons(c), leading cognitive impairment, including dementia. In elders, kidney Qi deficiency may also be related to gradual depletion of kidney essences(Jing) due to aging, according to traditional Chinese medicine.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
Wednesday, 8 February 2017
The holistic Prevention, Management and Treatment of Dementia In TCM herbal Treatment of Dementia - Radix rehmanniae(Di Huang)
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Herbal Medicine for Treatment of Dementia - Radix rehmanniae(Di Huang)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia(*).
Yuan Zhi, sweet and slightly cool herb is also known as Thinleaf Milkwort Root, used in TCM as antibiotic property, anti-viral property(732), anti cancer(734) and anti depression(733) agents in treating hepatitis B, tumors in the digestive, respiratory systems and in the uterus, etc., as it calms the heart, transforms phlegm, resolves furuncle and oedema, expel toxin, etc. by enhancing the functions of spleen, lung and liver channels.
Phytochemicals
1. Protein-bound polysaccharide (PSK)
2. Polysaccharopeptides (PSP)
3. Tenuifolin
4. Onjisaponin B
5. Etc.
Yuan Zhi used in the treatment and prevention of dementia(719) in traditional Chinese medicine, may be due to its effectiveness of phytochemicals in ameliorated amyloid pathology and related cognitive deficits(735). In aging related dementia, based on the history of use, and pharmacological investigation, Yuan Zhi showed a strong evidence in memory improving, including cholinergic, antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(736). Palmul-chongmyeong-tang, a traditional Chinese medicine formula containing Yuan zhi, exhibited improvement of learning and memory deficits, through reduction of loss of cholinergic immunoreactivity induced by cerebral ischemia(737).
1. In Alzheimer's disease (AD)
In free radical involved neuro-degeneration in Alzheimer's disease (AD), pretreament with Paeng-Jo-Yeon-Nyeon-Baek-Ja-In-Hwan (PJBH) prescription significantly exhibited cytoprotective effects, through elevating cell survival, antioxidant enzyme activities and resulted ecreased production of malondialdehyde (MDA) associated to Alzheimer's disease (AD)(738). Smart Soup (SS), composed of Rhizoma Acori Tatarinowii (AT), Poria cum RadixPini (PRP) and Radix Polygalae (RP), in oral administration of SS ameliorated the cognitive impairment of AD in animal model, effectively reduced Aβ levels, retarded Aβ amyloidosis and reduced Aβ-induced gliosis and neuronal loss(739).
2. In Parkinson's disease
Mutant Huntingtin gene caused by a poly-glutamine expansion in huntingtin( 740)and A53T α-synuclein, a protein found abundantly in the human brain, at the tips of nerve cells (neurons)(741) have shown to be associated with the development of Huntington disease and Parkinson disease. Yuan Zhi phytochemical, onjisaponin B and ethanol extracts showed to induce autophagy(743) through signalling pathway in participation of regulation of vascular function(742) in protection of cells against pro-neuro apoptosis via the mitochondrial pathway(744). According to college ofPharmacy and Kyung Hee East-West Pharmaceutical Research Institute, in mouse models of Parkinson's disease, Yuan Zhi also exhibited it protective effects on dopaminergic neurons induced by toxicity(745).
3. In Huntington diseases
Mutant Hungtintin caused of degradation of long-lived cytoplasmic proteins, protein complexes (the gel-like substance enclosed within the cell membrane)(747), or damaged organelles(tiny structures that perform very specific functions within cells)(748) attenuated autophagy in association of the development of Huntington diseases(746), Onjisaponin B, found in Yuan Zhi, effectively induced autophagy through its acceleration of both the removal of mutant huntingtin and and α-synuclein in PC-12 cells(749), which contain mixture of neuroblastic cells and eosinophilic cells(750).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(*) Traditional Chinese Medicine for Senile Dementia by Zhihong Lin,1 Jie Gu,1 Jin Xiu,1 Tingyan Mi,1 Jie Dong,1 and Jyoti Kumar Tiwari2(Hindawi)
(719) Chinese herbs for dementia diseases by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)
(732) First report of anti-Trichomonas vaginalis activity of the medicinal plant Polygala decumbens from the Brazilian semi-arid region, Caatinga by Frasson AP1, dos Santos O, Duarte M, da Silva Trentin D, Giordani RB, da Silva AG, da Silva MV, Tasca T, Macedo AJ.(PubMed)
(733) Potential antidepressant properties of Radix Polygalae (Yuan Zhi) by Liu P1, Hu Y, Guo DH, Wang DX, Tu HH, Ma L, Xie TT, Kong LY.(PubMed)
(734) High throughput screening of natural products for anti-mitotic effects in MDA-MB-231 human breast carcinoma cells. by Mazzio E1, Badisa R, Mack N, Deiab S, Soliman KF.(PubMed)
(735) Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits by Hou Y1, Wang Y2, Zhao J1, Li X1, Cui J1, Ding J2, Wang Y3, Zeng X1, Ling Y4, Shen X5, Chen S2, Huang C4, Pei G6.(PubMed)
(736) Traditional chinese medicine for senile dementia by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(737) Neuroprotective effect of palmul-chongmyeong-tang on ischemia-induced learning and memory deficits in the rat. by Yun YJ1, Lee B, Hahm DH, Kang SK, Han SM, Lee HJ, Pyun KH, Shim I.(PubMed)
(738) Traditional chinese medicine for senile dementia by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK. (PubMed)
(739) Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits by Hou Y1, Wang Y2, Zhao J1, Li X1, Cui J1, Ding J2, Wang Y3, Zeng X1, Ling Y4, Shen X5, Chen S2, Huang C4, Pei G6.(PubMed)
(740) Allele-specific silencing of mutant Huntington’s disease gene by Yu Zhang, Joshua Engelman, and Robert M. Friedlander*(PubMed)
(741) Alpha-synuclein(Wikipedia)
(742) Perivascular fat-mediated vascular dysfunction and remodeling through the AMPK/mTOR pathway in high-fat diet-induced obese rats by Liqun Ma1,2, Shuangtao Ma1,2, Hongbo He1, Dachun Yang1, Xiaoping Chen1, Zhidan Luo1, Daoyan Liu1 and Zhiming Zhu1(Hypertension research)
(743) Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells by Wu AG1, Wong VK, Xu SW, Chan WK, Ng CI, Liu L, Law BY.(PubMed)
(744) Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein by Sarkar S1, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC.(PubMed)
(745) Polygalae radix inhibits toxin-induced neuronal death in the Parkinson's disease models. by Choi JG1, Kim HG, Kim MC, Yang WM, Huh Y, Kim SY, Oh MS.(PubMed)
(746) Huntington's disease: degradation of mutant huntingtin by autophagy by Sarkar S1, Rubinsztein DC.(PubMed)
(747) Cytoplasm(Wikipedia)
(748) What are Organelles?(Wisegreek)
(749) Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells by Wu AG1, Wong VK, Xu SW, Chan WK, Ng CI, Liu L, Law BY.(PubMed)
(750) PC12 cell line(Wikipedia)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Herbal Medicine for Treatment of Dementia - Radix rehmanniae(Di Huang)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia(*).
Yuan Zhi, sweet and slightly cool herb is also known as Thinleaf Milkwort Root, used in TCM as antibiotic property, anti-viral property(732), anti cancer(734) and anti depression(733) agents in treating hepatitis B, tumors in the digestive, respiratory systems and in the uterus, etc., as it calms the heart, transforms phlegm, resolves furuncle and oedema, expel toxin, etc. by enhancing the functions of spleen, lung and liver channels.
Phytochemicals
1. Protein-bound polysaccharide (PSK)
2. Polysaccharopeptides (PSP)
3. Tenuifolin
4. Onjisaponin B
5. Etc.
Yuan Zhi used in the treatment and prevention of dementia(719) in traditional Chinese medicine, may be due to its effectiveness of phytochemicals in ameliorated amyloid pathology and related cognitive deficits(735). In aging related dementia, based on the history of use, and pharmacological investigation, Yuan Zhi showed a strong evidence in memory improving, including cholinergic, antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(736). Palmul-chongmyeong-tang, a traditional Chinese medicine formula containing Yuan zhi, exhibited improvement of learning and memory deficits, through reduction of loss of cholinergic immunoreactivity induced by cerebral ischemia(737).
1. In Alzheimer's disease (AD)
In free radical involved neuro-degeneration in Alzheimer's disease (AD), pretreament with Paeng-Jo-Yeon-Nyeon-Baek-Ja-In-Hwan (PJBH) prescription significantly exhibited cytoprotective effects, through elevating cell survival, antioxidant enzyme activities and resulted ecreased production of malondialdehyde (MDA) associated to Alzheimer's disease (AD)(738). Smart Soup (SS), composed of Rhizoma Acori Tatarinowii (AT), Poria cum RadixPini (PRP) and Radix Polygalae (RP), in oral administration of SS ameliorated the cognitive impairment of AD in animal model, effectively reduced Aβ levels, retarded Aβ amyloidosis and reduced Aβ-induced gliosis and neuronal loss(739).
2. In Parkinson's disease
Mutant Huntingtin gene caused by a poly-glutamine expansion in huntingtin( 740)and A53T α-synuclein, a protein found abundantly in the human brain, at the tips of nerve cells (neurons)(741) have shown to be associated with the development of Huntington disease and Parkinson disease. Yuan Zhi phytochemical, onjisaponin B and ethanol extracts showed to induce autophagy(743) through signalling pathway in participation of regulation of vascular function(742) in protection of cells against pro-neuro apoptosis via the mitochondrial pathway(744). According to college ofPharmacy and Kyung Hee East-West Pharmaceutical Research Institute, in mouse models of Parkinson's disease, Yuan Zhi also exhibited it protective effects on dopaminergic neurons induced by toxicity(745).
3. In Huntington diseases
Mutant Hungtintin caused of degradation of long-lived cytoplasmic proteins, protein complexes (the gel-like substance enclosed within the cell membrane)(747), or damaged organelles(tiny structures that perform very specific functions within cells)(748) attenuated autophagy in association of the development of Huntington diseases(746), Onjisaponin B, found in Yuan Zhi, effectively induced autophagy through its acceleration of both the removal of mutant huntingtin and and α-synuclein in PC-12 cells(749), which contain mixture of neuroblastic cells and eosinophilic cells(750).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(*) Traditional Chinese Medicine for Senile Dementia by Zhihong Lin,1 Jie Gu,1 Jin Xiu,1 Tingyan Mi,1 Jie Dong,1 and Jyoti Kumar Tiwari2(Hindawi)
(719) Chinese herbs for dementia diseases by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)
(732) First report of anti-Trichomonas vaginalis activity of the medicinal plant Polygala decumbens from the Brazilian semi-arid region, Caatinga by Frasson AP1, dos Santos O, Duarte M, da Silva Trentin D, Giordani RB, da Silva AG, da Silva MV, Tasca T, Macedo AJ.(PubMed)
(733) Potential antidepressant properties of Radix Polygalae (Yuan Zhi) by Liu P1, Hu Y, Guo DH, Wang DX, Tu HH, Ma L, Xie TT, Kong LY.(PubMed)
(734) High throughput screening of natural products for anti-mitotic effects in MDA-MB-231 human breast carcinoma cells. by Mazzio E1, Badisa R, Mack N, Deiab S, Soliman KF.(PubMed)
(735) Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits by Hou Y1, Wang Y2, Zhao J1, Li X1, Cui J1, Ding J2, Wang Y3, Zeng X1, Ling Y4, Shen X5, Chen S2, Huang C4, Pei G6.(PubMed)
(736) Traditional chinese medicine for senile dementia by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(737) Neuroprotective effect of palmul-chongmyeong-tang on ischemia-induced learning and memory deficits in the rat. by Yun YJ1, Lee B, Hahm DH, Kang SK, Han SM, Lee HJ, Pyun KH, Shim I.(PubMed)
(738) Traditional chinese medicine for senile dementia by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK. (PubMed)
(739) Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits by Hou Y1, Wang Y2, Zhao J1, Li X1, Cui J1, Ding J2, Wang Y3, Zeng X1, Ling Y4, Shen X5, Chen S2, Huang C4, Pei G6.(PubMed)
(740) Allele-specific silencing of mutant Huntington’s disease gene by Yu Zhang, Joshua Engelman, and Robert M. Friedlander*(PubMed)
(741) Alpha-synuclein(Wikipedia)
(742) Perivascular fat-mediated vascular dysfunction and remodeling through the AMPK/mTOR pathway in high-fat diet-induced obese rats by Liqun Ma1,2, Shuangtao Ma1,2, Hongbo He1, Dachun Yang1, Xiaoping Chen1, Zhidan Luo1, Daoyan Liu1 and Zhiming Zhu1(Hypertension research)
(743) Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells by Wu AG1, Wong VK, Xu SW, Chan WK, Ng CI, Liu L, Law BY.(PubMed)
(744) Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein by Sarkar S1, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC.(PubMed)
(745) Polygalae radix inhibits toxin-induced neuronal death in the Parkinson's disease models. by Choi JG1, Kim HG, Kim MC, Yang WM, Huh Y, Kim SY, Oh MS.(PubMed)
(746) Huntington's disease: degradation of mutant huntingtin by autophagy by Sarkar S1, Rubinsztein DC.(PubMed)
(747) Cytoplasm(Wikipedia)
(748) What are Organelles?(Wisegreek)
(749) Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells by Wu AG1, Wong VK, Xu SW, Chan WK, Ng CI, Liu L, Law BY.(PubMed)
(750) PC12 cell line(Wikipedia)
Tuesday, 7 February 2017
The holistic Prevention, Management and Treatment of Dementia In TCM Herbal Medicine - Radix rehmanniae(Di Huang)
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Herbal Medicine for Treatment of Dementia - Radix rehmanniae(Di Huang)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia(*).
Radix rehmanniae, a sweet and bitter herb, is also known as Di huang(sheng di huang is Cold in nature and shu di huang is Warm in nature), used in tradition Chinese medicine over thousand of years for treatment of the weakness caused by tuberculosis, vomiting blood, nose bleeding, coughing blood, bleeding in the uterus as its function of blood tonification, by enhancing function of heart, kidney, and liver channels(796).
Phytochemicals(797)
1. Sterol
2. Catalpol
3. Rehmanniosides A-D
4. Leonuride
5. Aucubin
6. Melittoside
7. Jioglutoside A-B, 6-O-E-feruloyl ajugol
8. Rehmaglutins A-D
9. Glutinoside, purpureaside C
10. Etc.
Di huang used in the treatment and prevention of dementia(798) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in ameliorated amyloid pathology and related cognitive deficits(799). In senile dementia, Di huang exhibited its elicit memory-improving effects, through its antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(760).
1. Neuroprotective effects
Paeng-Jo-Yeon-Nyeon-Baek-Ja-In-Hwan (PJBH), congaing Di huang and 17 other herbs, exhibited anti lipid peroxidation and antioxidant enzyme activities in decreased production of malondialdehyde (MDA) involved in neurodegeneration in Alzheimer's disease (AD)(801), through cholinesterase inhibited effects(802). Other prescriptive formula, palmul-chongmyeong-tang, in ischemia-induced rats, exhibited a protective effect against ischemia-induced neuronal and cognitive impairments of learning and memory(803).
2. Psychological symptoms
Polysaccharides extracted from shudihuang (radix rehmanniae preparata) in infant male rats study, significantly inhibited MSG-induced anxiety, through its phytochemicals in down regulation of beta-synuclein, protein DJ-1, linking toneurodegeneration in patient with dementia. etc.(804).
3. Improved earning and memory
In rats damaged thalamic arcuate nucleus, shu di-huang showed to up regulate the expression of hippocampal NGF, c-fos in improving the function of learning and memory(805). In dementia model, the herb decreased the times of mistakes and prolong the incubation period in step down task, through increased expression of hippocampal receptors, involved brain memory forming, organizing, and storing(806). Other formula, such as Ba-Wei-Di-Huang decoction, also enhanced capacity for learning and memory, through expression of autocrine motility factor receptor (AMFR), a multifunctional protein involved in cellular adhesion, proliferation, motility and apoptosis on animal model of Alzheimer's disease (AD)(807)(808)(809).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(796) Di Huang(Complementary and Alternative Healing University)
(797) HuangQin(Sen nong)
(798) Chinese herbs for dementia diseases. by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)
(799) Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits by Hou Y1, Wang Y2, Zhao J1, Li X1, Cui J1, Ding J2, Wang Y3, Zeng X1, Ling Y4, Shen X5, Chen S2, Huang C4, Pei G6.(PubMed)
(800) Traditional chinese medicine for senile dementia. by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(801) Attenuating effect of a traditional korean formulation, Paeng-Jo-Yeon-Nyeon-Baek-Ja-In-Hwan (PJBH), on hydrogen peroxide-induced injury in PC12 cells BY Koo BS1, Kim YK, Park KS, Chung KH, Kim CH.(PubMed)
(802) Huperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cells. by Zhang HY1, Tang XC.(PubMed)
(803) Neuroprotective effect of palmul-chongmyeong-tang on ischemia-induced learning and memory deficits in the rat. by Yun YJ1, Lee B, Hahm DH, Kang SK, Han SM, Lee HJ, Pyun KH, Shim I.(PubMed)
(804) Mechanism-based anti-anxiety effects of polysaccharides extracted from shudihuang (radix rehmanniae preparata) by two-dimensional electrophoresis analysis in rat hippocampus proteins. by Cui Y1, Rong C, Wang J, Cui C, Wang L, Feng Z, Feng J, Niu B.(PubMed)
(805) [Effect of shu di-huang on the expression of c-fos and NGF in hippocampi and learning and memory of rats damaged thalamic arcuate nucleus].[Article in Chinese] by Cui Y1, Hou SL, Yan ZH, Chang ZF.(PubMed)
(806) [Effect of shu di-huang on the transmitter and receptor of amino acid in brain and learning and memory of dementia model].[Article in Chinese] by Cui Y1, Yan ZH, Hou SL, Chang ZF.(PubMed)
(807) Autocrine motility factor receptor is involved in the process of learning and memory in the central nervous system. by Yang Y1, Cheng XR, Zhang GR, Zhou WX, Zhang YX.(PubMed)
(808) Detecting global and local hippocampal shape changes in Alzheimer's disease using statistical shape models. by Shen KK, Fripp J, Mériaudeau F, Chételat G, Salvado O, Bourgeat P; Alzheimer's Disease Neuroimaging Initiative.(PubMed)
(809) Memory impairments associated with hippocampal versus parahippocampal-gyrus atrophy: an MR volumetry study in Alzheimer's disease. by Köhler S1, Black SE, Sinden M, Szekely C, Kidron D, Parker JL, Foster JK, Moscovitch M, Winocour G, Szalai JP, Bronskill MJ.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Herbal Medicine for Treatment of Dementia - Radix rehmanniae(Di Huang)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia(*).
Radix rehmanniae, a sweet and bitter herb, is also known as Di huang(sheng di huang is Cold in nature and shu di huang is Warm in nature), used in tradition Chinese medicine over thousand of years for treatment of the weakness caused by tuberculosis, vomiting blood, nose bleeding, coughing blood, bleeding in the uterus as its function of blood tonification, by enhancing function of heart, kidney, and liver channels(796).
Phytochemicals(797)
1. Sterol
2. Catalpol
3. Rehmanniosides A-D
4. Leonuride
5. Aucubin
6. Melittoside
7. Jioglutoside A-B, 6-O-E-feruloyl ajugol
8. Rehmaglutins A-D
9. Glutinoside, purpureaside C
10. Etc.
Di huang used in the treatment and prevention of dementia(798) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in ameliorated amyloid pathology and related cognitive deficits(799). In senile dementia, Di huang exhibited its elicit memory-improving effects, through its antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(760).
1. Neuroprotective effects
Paeng-Jo-Yeon-Nyeon-Baek-Ja-In-Hwan (PJBH), congaing Di huang and 17 other herbs, exhibited anti lipid peroxidation and antioxidant enzyme activities in decreased production of malondialdehyde (MDA) involved in neurodegeneration in Alzheimer's disease (AD)(801), through cholinesterase inhibited effects(802). Other prescriptive formula, palmul-chongmyeong-tang, in ischemia-induced rats, exhibited a protective effect against ischemia-induced neuronal and cognitive impairments of learning and memory(803).
2. Psychological symptoms
Polysaccharides extracted from shudihuang (radix rehmanniae preparata) in infant male rats study, significantly inhibited MSG-induced anxiety, through its phytochemicals in down regulation of beta-synuclein, protein DJ-1, linking toneurodegeneration in patient with dementia. etc.(804).
3. Improved earning and memory
In rats damaged thalamic arcuate nucleus, shu di-huang showed to up regulate the expression of hippocampal NGF, c-fos in improving the function of learning and memory(805). In dementia model, the herb decreased the times of mistakes and prolong the incubation period in step down task, through increased expression of hippocampal receptors, involved brain memory forming, organizing, and storing(806). Other formula, such as Ba-Wei-Di-Huang decoction, also enhanced capacity for learning and memory, through expression of autocrine motility factor receptor (AMFR), a multifunctional protein involved in cellular adhesion, proliferation, motility and apoptosis on animal model of Alzheimer's disease (AD)(807)(808)(809).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(796) Di Huang(Complementary and Alternative Healing University)
(797) HuangQin(Sen nong)
(798) Chinese herbs for dementia diseases. by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)
(799) Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits by Hou Y1, Wang Y2, Zhao J1, Li X1, Cui J1, Ding J2, Wang Y3, Zeng X1, Ling Y4, Shen X5, Chen S2, Huang C4, Pei G6.(PubMed)
(800) Traditional chinese medicine for senile dementia. by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(801) Attenuating effect of a traditional korean formulation, Paeng-Jo-Yeon-Nyeon-Baek-Ja-In-Hwan (PJBH), on hydrogen peroxide-induced injury in PC12 cells BY Koo BS1, Kim YK, Park KS, Chung KH, Kim CH.(PubMed)
(802) Huperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cells. by Zhang HY1, Tang XC.(PubMed)
(803) Neuroprotective effect of palmul-chongmyeong-tang on ischemia-induced learning and memory deficits in the rat. by Yun YJ1, Lee B, Hahm DH, Kang SK, Han SM, Lee HJ, Pyun KH, Shim I.(PubMed)
(804) Mechanism-based anti-anxiety effects of polysaccharides extracted from shudihuang (radix rehmanniae preparata) by two-dimensional electrophoresis analysis in rat hippocampus proteins. by Cui Y1, Rong C, Wang J, Cui C, Wang L, Feng Z, Feng J, Niu B.(PubMed)
(805) [Effect of shu di-huang on the expression of c-fos and NGF in hippocampi and learning and memory of rats damaged thalamic arcuate nucleus].[Article in Chinese] by Cui Y1, Hou SL, Yan ZH, Chang ZF.(PubMed)
(806) [Effect of shu di-huang on the transmitter and receptor of amino acid in brain and learning and memory of dementia model].[Article in Chinese] by Cui Y1, Yan ZH, Hou SL, Chang ZF.(PubMed)
(807) Autocrine motility factor receptor is involved in the process of learning and memory in the central nervous system. by Yang Y1, Cheng XR, Zhang GR, Zhou WX, Zhang YX.(PubMed)
(808) Detecting global and local hippocampal shape changes in Alzheimer's disease using statistical shape models. by Shen KK, Fripp J, Mériaudeau F, Chételat G, Salvado O, Bourgeat P; Alzheimer's Disease Neuroimaging Initiative.(PubMed)
(809) Memory impairments associated with hippocampal versus parahippocampal-gyrus atrophy: an MR volumetry study in Alzheimer's disease. by Köhler S1, Black SE, Sinden M, Szekely C, Kidron D, Parker JL, Foster JK, Moscovitch M, Winocour G, Szalai JP, Bronskill MJ.(PubMed)
Monday, 6 February 2017
The holistic Prevention, Management and Treatment of Dementia In TCM Herbal Medicine - Radix angelica sinensis(Dang Qui)
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Herbal Medicine for Treatment of Dementia - Radix angelica sinensis(Dang Qui)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia(*).
Dang Qui (Angelica sinensis), a sweet, acrid, bitter, warm herb is a GenusAngelica from the family Apiaceae, indigenous to China, used as a Queen herb in traditional Chinese medicine as antispasmodic(771), analgesic(772) and vasodilatory(772) agents, and to balance the hormones(773) in women for a normal menstrual cycle and menstruation with condition of blood stasis(774)(775) and clots(775) by strengthening heart, spleen, and liver channels. The herb is also used to treat constipation(775), reduced swelling(776), expels pus(775), etc.
Phytochemicals
1. Beta-sitosterol
2. Coumarins
3. Butylidine
4. Phthalide
5. Ligustilide
6. Sesquiterpenes
7. Carvacrol
8. B-pinene
9. Camphene,
10. P-cymene,
11. B-phellandrene
12. Myrcene
13. 6-n-butyl-cycloheptadiene-1,4, 2-methyl-dodecane-5-one,
14. Acetophenone,
15. B-bisabolene,
16. Isoacroraene,
17. Acoradiene
18. Etc.
Dang qui used in the treatment and prevention of dementia(777) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in ameliorated amyloid pathology and related cognitive deficits(778). In aging related dementia, based on the history of use, and pharmacological investigation, dang Qui showed a strong evidence in memory improving, through iestrogen-like, cholinergic, antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(736). Palmul-chongmyeong-tang, a traditional Chinese medicine formula containing dang qui, exhibited improvement of learning and memory deficits, through reduction of loss of cholinergic immunoreactivity induced by cerebral ischemia(780).
Phthalide, a phytochemical found abundantly in dang qui, also an important bio-active constituent in Si-Wu-Tang and Fo-Shou-San, showed effectively in protect neurons against ROS-induced apoptosis by modulating apoptosis-related genes(781). Z-Ligustilide (LIG), a characterized phthalide, in rat study, exhibited anti vascular dementia and cerebrovascular insufficient activities through its antioxidant effect and improved cholinergic activity(782).
1. In cognitive impairments
In patients with cognitive impairment associated with chronic cerebral hypoperfusion, dang qui prevented neurotoxic effects of β-amyloid (Aβ), through its anti oxidative stress, inflammation and apoptosis functions(783). Its phytochemical Ligustilide (LIG), a main lipophilic component of Danggui also exhibited neuroprotective effect through anti-apoptosis of neuron and anti-proliferation of astrocyte both in cortex and in hippocampus in rat study(784).
2. Oxidative stress
Oxidative stress has been known to induced neurotoxicity and the underlying mechanisms causes of
Alzheimer's disease (AD). Decursin (D) and decursinol angelate (DA) found in dang qui, significantly suppressed Aβ aggregation and increased cellular resistance to Aβ-induced oxidative injury in the rat study(785). Coumarins, another chemical found in from Angelica, also effectively induced neuroprotective activity against glutamate-induced oxidative stress causes of cognitive deficits and brain damage(786), According to Seoul National University, 4 other new dihydropyranocoumarins were isolated from Angelica gigas roots through neuroprotective activity-guided isolation and were characterized as decursinol derivatives 4"-hydroxytigloyldecursinol, 4"-hydroxydecursin, (2"S,3"S)-epoxyangeloyldecursinol, and (2"R,3"R)-epoxyangeloyldecursinol, also exhibited significant protective activity against glutamate-induced neurotoxicity(787). In transgenic mice model, traditional Chinese herbal formula Jangwonhwan (LMK03-Jangwonhwan), containing dang qui, improved cognitive impairment through detection and inhibition of AD-like pathology, such as cytotoxicity and Abeta(1-42)and Abeta(1-40) levels and beta-amyloid plaque deposition(788)
3. Behavioral and psychological symptoms
In behavioral and psychological symptoms of dementia patients, combination of ferulic acid and Angelica archangelica extract oral administration, significantly attenuated neuropsychiatric symptoms in 19 of 20 patients, including delusions, hallucinations, agitation/aggression, anxiety, apathy/indifference, irritability/lability and aberrant behavior, according toNational Hospital Organization Kikuchi Hospital(789). Yokukansan, also known as TJ-54, composed of seven herbs, including dang qui, showed to inhibit a variety of effects on various neurological symptoms, such as memory disturbance and behavioral and psychological symptoms of dementia(791) without adverse effects(790), probably through its neuroprotective effect against glutamate-induced excitotoxicity(792). In ischemic brain tissue, Z-Ligustilide (LIG), a phytochemical found in dang qui, oral administration of 10 or 40 mg/kg/day, significantly reduced malondialdehyde levels and increased superoxide dismutase activity, probably through its antioxidant effect in improved cholinergic activity(793), anti-apoptosis of neuron and anti-proliferation of astrocyte both in cortex, hippocampus(794) and ameliorated cognitive dysfunction(795) in 2VO rats study.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(736) Traditional chinese medicine for senile dementia by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(777) Chinese herbs for dementia diseases. by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)
(778) Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits by Hou Y1, Wang Y2, Zhao J1, Li X1, Cui J1, Ding J2, Wang Y3, Zeng X1, Ling Y4, Shen X5, Chen S2, Huang C4, Pei G6.(PubMed)
(779) Traditional chinese medicine for senile dementia by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(780) Neuroprotective effect of palmul-chongmyeong-tang on ischemia-induced learning and memory deficits in the rat by Yun YJ1, Lee B, Hahm DH, Kang SK, Han SM, Lee HJ, Pyun KH, Shim I.(PubMed)
(781) Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong by Tang Y1, Zhu M, Yu S, Hua Y, Duan JA, Su S, Zhang X, Lu Y, Ding A.(PubMed)
(782) Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. by Kuang X1, Du JR, Liu YX, Zhang GY, Peng HY.(PubMed)
(783) Radix Angelica Sinensis that contains the component Z-ligustilide promotes adult neurogenesis to mediate recovery from cognitive impairment. by Xin J1, Zhang J, Yang Y, Deng M, Xie X.(PubMed)
(784) Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion. by Feng Z1, Lu Y, Wu X, Zhao P, Li J, Peng B, Qian Z, Zhu L.(PubMed)
(785) Protective effects of decursin and decursinol angelate against amyloid β-protein-induced oxidative stress in the PC12 cell line: the role of Nrf2 and antioxidant enzymes by Li L1, Li W, Jung SW, Lee YW, Kim YH.(PubMed)
(786) Decursinol and decursin protect primary cultured rat cortical cells from glutamate-induced neurotoxicity. by Kang SY1, Kim YC.(PubMed)
(787) Four new neuroprotective dihydropyranocoumarins from Angelica gigas by Kang SY1, Lee KY, Sung SH, Kim YC.(PubMed)
(788) A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Abeta(1-42) level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease by Seo JS1, Jung EY, Kim JH, Lyu YS, Han PL, Kang HW.(PubMed)
(789) Effect of ferulic acid and Angelica archangelica extract on behavioral and psychological symptoms of dementia in frontotemporal lobar degeneration and dementia with Lewy bodies. by Kimura T1, Hayashida H, Murata M, Takamatsu J.(PubMed)
(790) Use of Yokukansan (TJ-54) in the treatment of neurological disorders: a review. by de Caires S1, Steenkamp V.(PubMed)
(791) Effects of yokukansan, a traditional Japanese medicine, on memory disturbance and behavioral and psychological symptoms of dementia in thiamine-deficient rats. by Ikarashi Y1, Iizuka S, Imamura S, Yamaguchi T, Sekiguchi K, Kanno H, Kawakami Z, Yuzurihara M, Kase Y, Takeda S.(PubMed)
(792) Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells by Kawakami Z1, Kanno H, Ueki T, Terawaki K, Tabuchi M, Ikarashi Y, Kase Y.(PubMed)
(793) Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. by Kuang X1, Du JR, Liu YX, Zhang GY, Peng HY.(PubMed)
(794) Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion by Feng Z1, Lu Y, Wu X, Zhao P, Li J, Peng B, Qian Z, Zhu L.(PubMed)
(795) Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. by Kuang X1, Du JR, Liu YX, Zhang GY, Peng HY.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Herbal Medicine for Treatment of Dementia - Radix angelica sinensis(Dang Qui)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia(*).
Dang Qui (Angelica sinensis), a sweet, acrid, bitter, warm herb is a GenusAngelica from the family Apiaceae, indigenous to China, used as a Queen herb in traditional Chinese medicine as antispasmodic(771), analgesic(772) and vasodilatory(772) agents, and to balance the hormones(773) in women for a normal menstrual cycle and menstruation with condition of blood stasis(774)(775) and clots(775) by strengthening heart, spleen, and liver channels. The herb is also used to treat constipation(775), reduced swelling(776), expels pus(775), etc.
Phytochemicals
1. Beta-sitosterol
2. Coumarins
3. Butylidine
4. Phthalide
5. Ligustilide
6. Sesquiterpenes
7. Carvacrol
8. B-pinene
9. Camphene,
10. P-cymene,
11. B-phellandrene
12. Myrcene
13. 6-n-butyl-cycloheptadiene-1,4, 2-methyl-dodecane-5-one,
14. Acetophenone,
15. B-bisabolene,
16. Isoacroraene,
17. Acoradiene
18. Etc.
Dang qui used in the treatment and prevention of dementia(777) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in ameliorated amyloid pathology and related cognitive deficits(778). In aging related dementia, based on the history of use, and pharmacological investigation, dang Qui showed a strong evidence in memory improving, through iestrogen-like, cholinergic, antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(736). Palmul-chongmyeong-tang, a traditional Chinese medicine formula containing dang qui, exhibited improvement of learning and memory deficits, through reduction of loss of cholinergic immunoreactivity induced by cerebral ischemia(780).
Phthalide, a phytochemical found abundantly in dang qui, also an important bio-active constituent in Si-Wu-Tang and Fo-Shou-San, showed effectively in protect neurons against ROS-induced apoptosis by modulating apoptosis-related genes(781). Z-Ligustilide (LIG), a characterized phthalide, in rat study, exhibited anti vascular dementia and cerebrovascular insufficient activities through its antioxidant effect and improved cholinergic activity(782).
1. In cognitive impairments
In patients with cognitive impairment associated with chronic cerebral hypoperfusion, dang qui prevented neurotoxic effects of β-amyloid (Aβ), through its anti oxidative stress, inflammation and apoptosis functions(783). Its phytochemical Ligustilide (LIG), a main lipophilic component of Danggui also exhibited neuroprotective effect through anti-apoptosis of neuron and anti-proliferation of astrocyte both in cortex and in hippocampus in rat study(784).
2. Oxidative stress
Oxidative stress has been known to induced neurotoxicity and the underlying mechanisms causes of
Alzheimer's disease (AD). Decursin (D) and decursinol angelate (DA) found in dang qui, significantly suppressed Aβ aggregation and increased cellular resistance to Aβ-induced oxidative injury in the rat study(785). Coumarins, another chemical found in from Angelica, also effectively induced neuroprotective activity against glutamate-induced oxidative stress causes of cognitive deficits and brain damage(786), According to Seoul National University, 4 other new dihydropyranocoumarins were isolated from Angelica gigas roots through neuroprotective activity-guided isolation and were characterized as decursinol derivatives 4"-hydroxytigloyldecursinol, 4"-hydroxydecursin, (2"S,3"S)-epoxyangeloyldecursinol, and (2"R,3"R)-epoxyangeloyldecursinol, also exhibited significant protective activity against glutamate-induced neurotoxicity(787). In transgenic mice model, traditional Chinese herbal formula Jangwonhwan (LMK03-Jangwonhwan), containing dang qui, improved cognitive impairment through detection and inhibition of AD-like pathology, such as cytotoxicity and Abeta(1-42)and Abeta(1-40) levels and beta-amyloid plaque deposition(788)
3. Behavioral and psychological symptoms
In behavioral and psychological symptoms of dementia patients, combination of ferulic acid and Angelica archangelica extract oral administration, significantly attenuated neuropsychiatric symptoms in 19 of 20 patients, including delusions, hallucinations, agitation/aggression, anxiety, apathy/indifference, irritability/lability and aberrant behavior, according toNational Hospital Organization Kikuchi Hospital(789). Yokukansan, also known as TJ-54, composed of seven herbs, including dang qui, showed to inhibit a variety of effects on various neurological symptoms, such as memory disturbance and behavioral and psychological symptoms of dementia(791) without adverse effects(790), probably through its neuroprotective effect against glutamate-induced excitotoxicity(792). In ischemic brain tissue, Z-Ligustilide (LIG), a phytochemical found in dang qui, oral administration of 10 or 40 mg/kg/day, significantly reduced malondialdehyde levels and increased superoxide dismutase activity, probably through its antioxidant effect in improved cholinergic activity(793), anti-apoptosis of neuron and anti-proliferation of astrocyte both in cortex, hippocampus(794) and ameliorated cognitive dysfunction(795) in 2VO rats study.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(736) Traditional chinese medicine for senile dementia by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(777) Chinese herbs for dementia diseases. by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)
(778) Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits by Hou Y1, Wang Y2, Zhao J1, Li X1, Cui J1, Ding J2, Wang Y3, Zeng X1, Ling Y4, Shen X5, Chen S2, Huang C4, Pei G6.(PubMed)
(779) Traditional chinese medicine for senile dementia by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(780) Neuroprotective effect of palmul-chongmyeong-tang on ischemia-induced learning and memory deficits in the rat by Yun YJ1, Lee B, Hahm DH, Kang SK, Han SM, Lee HJ, Pyun KH, Shim I.(PubMed)
(781) Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong by Tang Y1, Zhu M, Yu S, Hua Y, Duan JA, Su S, Zhang X, Lu Y, Ding A.(PubMed)
(782) Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. by Kuang X1, Du JR, Liu YX, Zhang GY, Peng HY.(PubMed)
(783) Radix Angelica Sinensis that contains the component Z-ligustilide promotes adult neurogenesis to mediate recovery from cognitive impairment. by Xin J1, Zhang J, Yang Y, Deng M, Xie X.(PubMed)
(784) Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion. by Feng Z1, Lu Y, Wu X, Zhao P, Li J, Peng B, Qian Z, Zhu L.(PubMed)
(785) Protective effects of decursin and decursinol angelate against amyloid β-protein-induced oxidative stress in the PC12 cell line: the role of Nrf2 and antioxidant enzymes by Li L1, Li W, Jung SW, Lee YW, Kim YH.(PubMed)
(786) Decursinol and decursin protect primary cultured rat cortical cells from glutamate-induced neurotoxicity. by Kang SY1, Kim YC.(PubMed)
(787) Four new neuroprotective dihydropyranocoumarins from Angelica gigas by Kang SY1, Lee KY, Sung SH, Kim YC.(PubMed)
(788) A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Abeta(1-42) level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease by Seo JS1, Jung EY, Kim JH, Lyu YS, Han PL, Kang HW.(PubMed)
(789) Effect of ferulic acid and Angelica archangelica extract on behavioral and psychological symptoms of dementia in frontotemporal lobar degeneration and dementia with Lewy bodies. by Kimura T1, Hayashida H, Murata M, Takamatsu J.(PubMed)
(790) Use of Yokukansan (TJ-54) in the treatment of neurological disorders: a review. by de Caires S1, Steenkamp V.(PubMed)
(791) Effects of yokukansan, a traditional Japanese medicine, on memory disturbance and behavioral and psychological symptoms of dementia in thiamine-deficient rats. by Ikarashi Y1, Iizuka S, Imamura S, Yamaguchi T, Sekiguchi K, Kanno H, Kawakami Z, Yuzurihara M, Kase Y, Takeda S.(PubMed)
(792) Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells by Kawakami Z1, Kanno H, Ueki T, Terawaki K, Tabuchi M, Ikarashi Y, Kase Y.(PubMed)
(793) Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. by Kuang X1, Du JR, Liu YX, Zhang GY, Peng HY.(PubMed)
(794) Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion by Feng Z1, Lu Y, Wu X, Zhao P, Li J, Peng B, Qian Z, Zhu L.(PubMed)
(795) Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. by Kuang X1, Du JR, Liu YX, Zhang GY, Peng HY.(PubMed)
Sunday, 5 February 2017
The holistic Prevention, Management and Treatment of Dementia In TCM Herbal Medicine - Radix glycyrrhizae(Gan Cao)
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Herbal Medicine for Treatment of Dementia - Radix glycyrrhizae(Gan Cao)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia(*).
Gan Cao, a sweet and neutral herb, also known as Licorice root, has been used in TCM as anti allergy(752), anti inflammation(751), anti ulcer(753), anti convulsion(754) agents and to treat stomach weakness(755), tired and lack of strength(756), enhance cardiac performance(757) and short of breath(758), cough with abundance of phlegm(751), etc., as it tonifies the Spleen, benefits the Qi, moistens the Lungs, calms cough, deaf or acute pain, by enhancing the function of all 12 channels.
Phytochemicals
1. Glycyrrhizic acid
2. 24-hydroxyglycyrrhetic acid
3. Licorice saponins A3
4. Licochalcone A
5. Licochalcone B
6. Licoflavone
7. Liquiritin
8. Liquiritigenin
9. Isoliquiritigenin
10. Ononins
11. 4′,7-dihydroxyflavone
12. Etc.
Gan Cao used in the treatment and prevention of dementia(719) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in ameliorated amyloid pathology and related cognitive deficits(759). In senile dementia, Gan Cao exhibited its elicit memory-improving effects, through its antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(760).
1. In Alzheimer's disease (AD)
Vascular risk factors (VRF) has shown strong evidence in contribution to cognitive decline and the development of Alzheimer's disease (AD)(763) and dementia(761). Sini Decoction, a TCM formula containing Gan Cao enhanced cardiac function through significant suppression of lipid peroxidation(765) of myocardial homogenate(764), via scavenge oxygen free radicals activity(764). According to Korea Food Research Institute, Gan Cao attenuated the Amyloid beta protein (Abeta) involved in the progression ofAlzheimer's disease (AD), through inhibition of Acetylcholinesterase activity(762), probably via mediation antioxidant actions against oxidative stress(762).
2. In Parkinson's diseases(PD)
Kampo kami-shoyo-san (TJ-24), a Korean traditional herbal medicine, containing Gan Cao, significantly reduce tremor, disturbances in muscular movement in antipsychotic-induced parkinsonism(766). The formula also showed effectively in relieved symptoms of panic attacks, anticipatory anxiety(767). Liquiritin, a flavonoid extracted from Glycyrrhizae radix, significantly promoted the neurite outgrowth in dose dependant manners, through overexpression of neural related genes, such as neurogenin 3, neurofibromatosis 1, associated to Alzheimer's disease or Parkinson's disease(768).
3. In learning and memory
Oral administration of Glycyrrhizae radix (GR) in rat study, showed to reduce anxiety and promote learning and memory in rats, by attenuating the behavioral and neurochemical impairments caused by repeated stress-induced alterations(770). Palmul-chongmyeong-tang, containing Gan Cao used in used as herbal medicine against ischemia, may be a potential agent for treatment of vascular dementia as it significantly improved learning and memory and attenuated cognitive impairment through reduction of the loss of cholinergic immunoreactivity in the hippocampus induced by cerebral ischemia in rat model(769).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(719) Chinese herbs for dementia diseases by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)(759) Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits by Hou Y1, Wang Y2, Zhao J1, Li X1, Cui J1, Ding J2, Wang Y3, Zeng X1, Ling Y4, Shen X5, Chen S2, Huang C4, Pei G6.(PubMed)
(760) Traditional chinese medicine for senile dementia by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(761) Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease by Li J, Wang YJ, Zhang M, Xu ZQ, Gao CY, Fang CQ, Yan JC, Zhou HD; Chongqing Ageing Study Group.(PubMed)
) (762) Protective effects of Glycyrrhiza uralensis Fisch. on the cognitive deficits caused by beta-amyloid peptide 25-35 in young mice by Ahn J1, Um M, Choi W, Kim S, Ha T.(PubMed)
(763) Treatment of vascular risk factors is associated with slower decline in Alzheimer disease.by Deschaintre Y1, Richard F, Leys D, Pasquier F.(PubMed).
(764) [In vitro experiment on scavenging oxy-radical and suppressing myocardial lipid peroxidation with sini decoction].[Article in Chinese] by Wu W1, Luo H, Hou C.(PubMed)
(765) [Anti-lipid peroxidation effects of sini decoction and its components on ischemic myocardium and the dose- and time-effects].[Article in Chinese] by Wu W1, Hou C, Luo H, Jin W, Luo C.(PubMed)
(766) Effectiveness of the Kampo kami-shoyo-san (TJ-24) for tremor of antipsychotic-induced parkinsonism by Ishikawa T1, Funahashi T, Kudo J.(PubMed)
(767) Four cases of panic disorder successfully treated with Kampo (Japanese herbal) medicines: Kami-shoyo-san and Hange-koboku-to. by Mantani N1, Hisanaga A, Kogure T, Kita T, Shimada Y, Terasawa K.(PubMed)
(768) Liquiritin potentiate neurite outgrowth induced by nerve growth factor in PC12 cells by Chen ZA1, Wang JL, Liu RT, Ren JP, Wen LQ, Chen XJ, Bian GX.(PubMed)
(769) Neuroprotective effect of palmul-chongmyeong-tang on ischemia-induced learning and memory deficits in the rat. by Yun YJ1, Lee B, Hahm DH, Kang SK, Han SM, Lee HJ, Pyun KH, Shim I.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Herbal Medicine for Treatment of Dementia - Radix glycyrrhizae(Gan Cao)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia(*).
Gan Cao, a sweet and neutral herb, also known as Licorice root, has been used in TCM as anti allergy(752), anti inflammation(751), anti ulcer(753), anti convulsion(754) agents and to treat stomach weakness(755), tired and lack of strength(756), enhance cardiac performance(757) and short of breath(758), cough with abundance of phlegm(751), etc., as it tonifies the Spleen, benefits the Qi, moistens the Lungs, calms cough, deaf or acute pain, by enhancing the function of all 12 channels.
Phytochemicals
1. Glycyrrhizic acid
2. 24-hydroxyglycyrrhetic acid
3. Licorice saponins A3
4. Licochalcone A
5. Licochalcone B
6. Licoflavone
7. Liquiritin
8. Liquiritigenin
9. Isoliquiritigenin
10. Ononins
11. 4′,7-dihydroxyflavone
12. Etc.
Gan Cao used in the treatment and prevention of dementia(719) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in ameliorated amyloid pathology and related cognitive deficits(759). In senile dementia, Gan Cao exhibited its elicit memory-improving effects, through its antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(760).
1. In Alzheimer's disease (AD)
Vascular risk factors (VRF) has shown strong evidence in contribution to cognitive decline and the development of Alzheimer's disease (AD)(763) and dementia(761). Sini Decoction, a TCM formula containing Gan Cao enhanced cardiac function through significant suppression of lipid peroxidation(765) of myocardial homogenate(764), via scavenge oxygen free radicals activity(764). According to Korea Food Research Institute, Gan Cao attenuated the Amyloid beta protein (Abeta) involved in the progression ofAlzheimer's disease (AD), through inhibition of Acetylcholinesterase activity(762), probably via mediation antioxidant actions against oxidative stress(762).
2. In Parkinson's diseases(PD)
Kampo kami-shoyo-san (TJ-24), a Korean traditional herbal medicine, containing Gan Cao, significantly reduce tremor, disturbances in muscular movement in antipsychotic-induced parkinsonism(766). The formula also showed effectively in relieved symptoms of panic attacks, anticipatory anxiety(767). Liquiritin, a flavonoid extracted from Glycyrrhizae radix, significantly promoted the neurite outgrowth in dose dependant manners, through overexpression of neural related genes, such as neurogenin 3, neurofibromatosis 1, associated to Alzheimer's disease or Parkinson's disease(768).
3. In learning and memory
Oral administration of Glycyrrhizae radix (GR) in rat study, showed to reduce anxiety and promote learning and memory in rats, by attenuating the behavioral and neurochemical impairments caused by repeated stress-induced alterations(770). Palmul-chongmyeong-tang, containing Gan Cao used in used as herbal medicine against ischemia, may be a potential agent for treatment of vascular dementia as it significantly improved learning and memory and attenuated cognitive impairment through reduction of the loss of cholinergic immunoreactivity in the hippocampus induced by cerebral ischemia in rat model(769).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(719) Chinese herbs for dementia diseases by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)(759) Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits by Hou Y1, Wang Y2, Zhao J1, Li X1, Cui J1, Ding J2, Wang Y3, Zeng X1, Ling Y4, Shen X5, Chen S2, Huang C4, Pei G6.(PubMed)
(760) Traditional chinese medicine for senile dementia by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(761) Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease by Li J, Wang YJ, Zhang M, Xu ZQ, Gao CY, Fang CQ, Yan JC, Zhou HD; Chongqing Ageing Study Group.(PubMed)
) (762) Protective effects of Glycyrrhiza uralensis Fisch. on the cognitive deficits caused by beta-amyloid peptide 25-35 in young mice by Ahn J1, Um M, Choi W, Kim S, Ha T.(PubMed)
(763) Treatment of vascular risk factors is associated with slower decline in Alzheimer disease.by Deschaintre Y1, Richard F, Leys D, Pasquier F.(PubMed).
(764) [In vitro experiment on scavenging oxy-radical and suppressing myocardial lipid peroxidation with sini decoction].[Article in Chinese] by Wu W1, Luo H, Hou C.(PubMed)
(765) [Anti-lipid peroxidation effects of sini decoction and its components on ischemic myocardium and the dose- and time-effects].[Article in Chinese] by Wu W1, Hou C, Luo H, Jin W, Luo C.(PubMed)
(766) Effectiveness of the Kampo kami-shoyo-san (TJ-24) for tremor of antipsychotic-induced parkinsonism by Ishikawa T1, Funahashi T, Kudo J.(PubMed)
(767) Four cases of panic disorder successfully treated with Kampo (Japanese herbal) medicines: Kami-shoyo-san and Hange-koboku-to. by Mantani N1, Hisanaga A, Kogure T, Kita T, Shimada Y, Terasawa K.(PubMed)
(768) Liquiritin potentiate neurite outgrowth induced by nerve growth factor in PC12 cells by Chen ZA1, Wang JL, Liu RT, Ren JP, Wen LQ, Chen XJ, Bian GX.(PubMed)
(769) Neuroprotective effect of palmul-chongmyeong-tang on ischemia-induced learning and memory deficits in the rat. by Yun YJ1, Lee B, Hahm DH, Kang SK, Han SM, Lee HJ, Pyun KH, Shim I.(PubMed)
Saturday, 4 February 2017
The holistic Prevention, Management and Treatment of Dementia In TCM Herbal Medicine - Poria cocos(Fu Ling)
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Herbal Medicine for Treatment of Dementia - Poria cocos(Fu Ling)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia(*).
Fu Ling, fu shen or fu ling pi also known as Poria, the bland, sweet and neutral herb has been used in TCM as diuretics(711) and to treat urinary difficulty(711), edema(711), diarrhea(715), emesis(717), vomiting(716), dizziness(716), heart diseases(717)(718), etc., as it eliminates water, strengthens the Spleen, calms the Mind, etc., by enhancing the functions of heart, spleen, lung and kidney channels. The herb has shown to exhibit various biological activities including anti-tumor(713), anti-inflammation(712), immunodepression(712) and antioxidant(711)(713)(714).
Phytochemicals
1. Pachymose
2. Albuninoid
3. Pachymaran
4. B-pachyman
5. B-pachymanase,
6. Pachymic acid,
7. Tumulosic acid,
8. Eburioic acid,
9. Pinicolic acid,
10. Etc.
Fu Ling(720) used for treatment and prevention of dementia(719) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in attenuation of oxidative stress in initiation of neurodegeneration and enhanced neuroprotection(719).
1. Learning and memory impairments
Kyung-Ok-Ko (KOK), the traditional Chine medicine formula, containing Poria cocos, showed effectively in exhibition of its anti-inflammatory effects in protection of brain neuron through attenuating memory(721)(722) and learning impairment(723). In senile dementia, herbal Poria cocos also elicited memory-improving effects in vivo and in vitro through its sinapic acid, tenuifolin, isoliquiritigenin, liquiritigenin, glabridin, ferulic acid antioxidants via cholinergic, antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(722).Yokukansan (TJ-54), another Chinese medicine formula, containing Poria cocos, also inhibited neurological disorders, including dementia and Alzheimer's disease(723) symptoms of memory and behaviors disturbance(724), probably through its anti-cholinesterase activity(725).
2. Cognitive dysfunction
In patients of dementia with cognitive dysfunction, Liuwei Dihuang decoction, containing Poria cocos, showed significantly in attenuated the neural apoptosis, inflammation and Aβ deposition in the hippocampus and cerebral corte(726) causes of cognitive impairment(727) in streptozotocin-induced diabetic rat. In spatial cognition, herbal formula Toki-Shakuyaku-San and fractions of Angelica acutiloba, improved memory and working memory impaired by scopolamine in animal study(728).
3. Alzheimer disease
In mouse model of Alzheimer disease, herbal formula Jangwonhwan, not only showed effectively in ameliorated AD-like pathology, but also exhibited its neuroprotective effects against Abeta-induced cell death, and Abeta accumulation and plaque deposition in the brain(730), probably through attenuation of reactive oxidative stress(729), by suppressed Aβ-induced apoptosis and ROS production(731).Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(*) Traditional Chinese Medicine for Senile Dementia by Zhihong Lin,1 Jie Gu,1 Jin Xiu,1 Tingyan Mi,1 Jie Dong,1 and Jyoti Kumar Tiwari2(Hindawi)
(711) [Chemical constituents of surface layer of Poria cocos and their pharmacological properties (I)].[Article in Chinese] by Feng YL1, Zhao YY, Ding F, Xi ZH, Tian T, Zhou F, Du X, Chen DQ, Wei F, Cheng XL, Lin RC.(PubMed)
(712) Chemical constituents and pharmacological properties of Poria cocos by Ríos JL1.(PubMed)
(713) Biological activities and potential health benefits of polysaccharides from Poria cocos and their derivatives. by Sun Y1.(PubMed)
(714) Antioxidant activity of carboxymethyl (1→3)-β-d-glucan (from the sclerotium of Poria cocos) sulfate (in vitro) by Wang Q1, Chen S2, Han L2, Lian M2, Wen Z2, Jiayinaguli T2, Liu L2, Sun R2, Cao Y3.(PubMed)
(715) [Clinical and experimental study on the treatment of children diarrhea by granule of children-diarrhea fast-stopping].[Article in Chinese] by Li YL1.(PubMed)
(716) Effects of triterpenoids from Poria cocos Wolf on the serotonin type 3A receptor-mediated ion current in Xenopus oocytes by Lee JH1, Lee YJ, Shin JK, Nam JW, Nah SY, Kim SH, Jeong JH, Kim Y, Shin M, Hong M, Seo EK, Bae H.(PubMed)
(717) Sclederma of Poria cocos exerts its diuretic effect via suppression of renal aquaporin-2 expression in rats with chronic heart failure by Wu ZL1, Ren H2, Lai WY3, Lin S1, Jiang RY1, Ye TC1, Shen QB1, Zeng QC3, Xu DL4.(PubMed)
(718) Anti-rejection effect of ethanol extract of Poria cocos wolf in rats after cardiac allograft implantation by Zhang GW1, Liu HY, Xia QM, Li JQ, Lü H, Zhang QH, Yao ZF.(PubMed)
(719) Chinese herbs for dementia diseases by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)
(720) Chinese herbs for memory disorders: a review and systematic analysis of classical herbal literature by May BH1, Lu C, Lu Y, Zhang AL, Xue CC.(PubMed)
(721) Chinese herbs for dementia diseases by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)
(722) Traditional chinese medicine for senile dementia.by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(722a) Are herbal compounds the next frontier for alleviating learning and memory impairments? An integrative look at memory, dementia and the promising therapeutics of traditional chinese medicines by Jesky R1, Hailong C.(PubMed)
(723) Use of Yokukansan (TJ-54) in the treatment of neurological disorders: a review. by de Caires S1, Steenkamp V.(PubMed)
(724) Effects of yokukansan, a traditional Japanese medicine, on memory disturbance and behavioral and psychological symptoms of dementia in thiamine-deficient rats by Ikarashi Y1, Iizuka S, Imamura S, Yamaguchi T, Sekiguchi K, Kanno H, Kawakami Z, Yuzurihara M, Kase Y, Takeda S.(PubMed)
(725) Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity by Oh MH1, Houghton PJ, Whang WK, Cho JH.(PubMed)
(726) Neuroprotective effect of Liuwei Dihuang decoction on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. by Liu JP1, Feng L, Zhang MH, Ma DY, Wang SY, Gu J, Fu Q, Qu R, Ma SP.(PubMed)
(727) Liuwei Dihuang decoction facilitates the induction of long-term potentiation (LTP) in senescence accelerated mouse/prone 8 (SAMP8) hippocampal slices by inhibiting voltage-dependent calcium channels (VDCCs) and promoting N-methyl-d-aspartate receptor (NMDA) receptors by Huang Y1, Zhang H, Yang S, Qiao H, Zhou W, Zhang Y(PubMed)
(728) Determination of the effectiveness of components of the herbal medicine Toki-Shakuyaku-San and fractions of Angelica acutiloba in improving the scopolamine-induced impairment of rat's spatial cognition in eight-armed radial maze test. by Hatip-Al-Khatib I1, Egashira N, Mishima K, Iwasaki K, Iwasaki K, Kurauchi K, Inui K, Ikeda T, Fujiwara M.(PubMed)
(729) A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Abeta(1-42) level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease by Seo JS1, Jung EY, Kim JH, Lyu YS, Han PL, Kang HW.(PubMed)
(730) A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Abeta(1-42) level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease by Seo JS1, Jung EY, Kim JH, Lyu YS, Han PL, Kang HW.(PubMed)
(731) A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease by Jeon S1, Bose S, Hur J, Jun K, Kim YK, Cho KS, Koo BS.(PubMed)
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Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Herbal Medicine for Treatment of Dementia - Poria cocos(Fu Ling)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia(*).
Fu Ling, fu shen or fu ling pi also known as Poria, the bland, sweet and neutral herb has been used in TCM as diuretics(711) and to treat urinary difficulty(711), edema(711), diarrhea(715), emesis(717), vomiting(716), dizziness(716), heart diseases(717)(718), etc., as it eliminates water, strengthens the Spleen, calms the Mind, etc., by enhancing the functions of heart, spleen, lung and kidney channels. The herb has shown to exhibit various biological activities including anti-tumor(713), anti-inflammation(712), immunodepression(712) and antioxidant(711)(713)(714).
Phytochemicals
1. Pachymose
2. Albuninoid
3. Pachymaran
4. B-pachyman
5. B-pachymanase,
6. Pachymic acid,
7. Tumulosic acid,
8. Eburioic acid,
9. Pinicolic acid,
10. Etc.
Fu Ling(720) used for treatment and prevention of dementia(719) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in attenuation of oxidative stress in initiation of neurodegeneration and enhanced neuroprotection(719).
1. Learning and memory impairments
Kyung-Ok-Ko (KOK), the traditional Chine medicine formula, containing Poria cocos, showed effectively in exhibition of its anti-inflammatory effects in protection of brain neuron through attenuating memory(721)(722) and learning impairment(723). In senile dementia, herbal Poria cocos also elicited memory-improving effects in vivo and in vitro through its sinapic acid, tenuifolin, isoliquiritigenin, liquiritigenin, glabridin, ferulic acid antioxidants via cholinergic, antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(722).Yokukansan (TJ-54), another Chinese medicine formula, containing Poria cocos, also inhibited neurological disorders, including dementia and Alzheimer's disease(723) symptoms of memory and behaviors disturbance(724), probably through its anti-cholinesterase activity(725).
2. Cognitive dysfunction
In patients of dementia with cognitive dysfunction, Liuwei Dihuang decoction, containing Poria cocos, showed significantly in attenuated the neural apoptosis, inflammation and Aβ deposition in the hippocampus and cerebral corte(726) causes of cognitive impairment(727) in streptozotocin-induced diabetic rat. In spatial cognition, herbal formula Toki-Shakuyaku-San and fractions of Angelica acutiloba, improved memory and working memory impaired by scopolamine in animal study(728).
3. Alzheimer disease
In mouse model of Alzheimer disease, herbal formula Jangwonhwan, not only showed effectively in ameliorated AD-like pathology, but also exhibited its neuroprotective effects against Abeta-induced cell death, and Abeta accumulation and plaque deposition in the brain(730), probably through attenuation of reactive oxidative stress(729), by suppressed Aβ-induced apoptosis and ROS production(731).Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
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References
(*) Traditional Chinese Medicine for Senile Dementia by Zhihong Lin,1 Jie Gu,1 Jin Xiu,1 Tingyan Mi,1 Jie Dong,1 and Jyoti Kumar Tiwari2(Hindawi)
(711) [Chemical constituents of surface layer of Poria cocos and their pharmacological properties (I)].[Article in Chinese] by Feng YL1, Zhao YY, Ding F, Xi ZH, Tian T, Zhou F, Du X, Chen DQ, Wei F, Cheng XL, Lin RC.(PubMed)
(712) Chemical constituents and pharmacological properties of Poria cocos by Ríos JL1.(PubMed)
(713) Biological activities and potential health benefits of polysaccharides from Poria cocos and their derivatives. by Sun Y1.(PubMed)
(714) Antioxidant activity of carboxymethyl (1→3)-β-d-glucan (from the sclerotium of Poria cocos) sulfate (in vitro) by Wang Q1, Chen S2, Han L2, Lian M2, Wen Z2, Jiayinaguli T2, Liu L2, Sun R2, Cao Y3.(PubMed)
(715) [Clinical and experimental study on the treatment of children diarrhea by granule of children-diarrhea fast-stopping].[Article in Chinese] by Li YL1.(PubMed)
(716) Effects of triterpenoids from Poria cocos Wolf on the serotonin type 3A receptor-mediated ion current in Xenopus oocytes by Lee JH1, Lee YJ, Shin JK, Nam JW, Nah SY, Kim SH, Jeong JH, Kim Y, Shin M, Hong M, Seo EK, Bae H.(PubMed)
(717) Sclederma of Poria cocos exerts its diuretic effect via suppression of renal aquaporin-2 expression in rats with chronic heart failure by Wu ZL1, Ren H2, Lai WY3, Lin S1, Jiang RY1, Ye TC1, Shen QB1, Zeng QC3, Xu DL4.(PubMed)
(718) Anti-rejection effect of ethanol extract of Poria cocos wolf in rats after cardiac allograft implantation by Zhang GW1, Liu HY, Xia QM, Li JQ, Lü H, Zhang QH, Yao ZF.(PubMed)
(719) Chinese herbs for dementia diseases by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)
(720) Chinese herbs for memory disorders: a review and systematic analysis of classical herbal literature by May BH1, Lu C, Lu Y, Zhang AL, Xue CC.(PubMed)
(721) Chinese herbs for dementia diseases by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)
(722) Traditional chinese medicine for senile dementia.by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(722a) Are herbal compounds the next frontier for alleviating learning and memory impairments? An integrative look at memory, dementia and the promising therapeutics of traditional chinese medicines by Jesky R1, Hailong C.(PubMed)
(723) Use of Yokukansan (TJ-54) in the treatment of neurological disorders: a review. by de Caires S1, Steenkamp V.(PubMed)
(724) Effects of yokukansan, a traditional Japanese medicine, on memory disturbance and behavioral and psychological symptoms of dementia in thiamine-deficient rats by Ikarashi Y1, Iizuka S, Imamura S, Yamaguchi T, Sekiguchi K, Kanno H, Kawakami Z, Yuzurihara M, Kase Y, Takeda S.(PubMed)
(725) Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity by Oh MH1, Houghton PJ, Whang WK, Cho JH.(PubMed)
(726) Neuroprotective effect of Liuwei Dihuang decoction on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. by Liu JP1, Feng L, Zhang MH, Ma DY, Wang SY, Gu J, Fu Q, Qu R, Ma SP.(PubMed)
(727) Liuwei Dihuang decoction facilitates the induction of long-term potentiation (LTP) in senescence accelerated mouse/prone 8 (SAMP8) hippocampal slices by inhibiting voltage-dependent calcium channels (VDCCs) and promoting N-methyl-d-aspartate receptor (NMDA) receptors by Huang Y1, Zhang H, Yang S, Qiao H, Zhou W, Zhang Y(PubMed)
(728) Determination of the effectiveness of components of the herbal medicine Toki-Shakuyaku-San and fractions of Angelica acutiloba in improving the scopolamine-induced impairment of rat's spatial cognition in eight-armed radial maze test. by Hatip-Al-Khatib I1, Egashira N, Mishima K, Iwasaki K, Iwasaki K, Kurauchi K, Inui K, Ikeda T, Fujiwara M.(PubMed)
(729) A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Abeta(1-42) level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease by Seo JS1, Jung EY, Kim JH, Lyu YS, Han PL, Kang HW.(PubMed)
(730) A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Abeta(1-42) level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease by Seo JS1, Jung EY, Kim JH, Lyu YS, Han PL, Kang HW.(PubMed)
(731) A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease by Jeon S1, Bose S, Hur J, Jun K, Kim YK, Cho KS, Koo BS.(PubMed)
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