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Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women. Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).
In Traditional Chinese Perspective
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches. Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(1247a)(1247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(1247b).
PCOs Treatment according traditional Chinese medicine
Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into
Kidney yin deficiency
Along with common symptoms mentioned above, women with PCOs diagnosed with kidney yin deficiency may also experience yin vacuity induced cold expressive syndrome, including soreness of waist and knees(1848), lassitude(1848) and fatigue(1848), short breath(1848), poor appetite(1848), aversion to cold(184), cold extremities(1848), ringing in the ears(1850), migraine(1849), hearing problems(1850), a dry mouth and throat(1851), pale fingernails(1851), tidal fever(1851)and night sweating(1851), soles(1851) and chest(1851), constipation(1852),,......... as the kidneys no longer perform their functions of regulating fluid in moistening and nourishing organs and tissues of the body. According to TCM, too much cold/raw foods can aggravate the condition.
In the review of the Data base provided by PubMed, kidney yin deficiency may induce functional impairment or metabolic derangements in vital organs/tissues(1853) persuaded a conglomeration of sundry chronic disease state(1853), cognitive dysfunction(1854), vasomotor symptoms(1855),..... leading to accumulation of fluid in the body organ, promoted accentuation of inflammatory development of phlegm.
Kidney yin deficiency has shown to alter amino acid metabolism(1856), energy metabolism(1856) and gut microflora(1856), anovulatory infertility(1857) and
hypertension(1858), hyperinsulinemia(1859) and hyperandrogenia(1859)..... of which related to symptoms of PCOs(1859).
3. Shiitake mushroom
Shiitake mushroom is an edible mushroom, genus Lentinula, belongings to family Marasmiaceae, native to East Asia and widely cultivated for consumption for its health benefits and commercial purpose in many Asian countries(1944). The sweet and neural herb has been used in traditional Chinese as anti-inflammatory(1951)(1952), antioxidative(1952)(1953)(1954), immunodulatory(1949)(1950)(1961), anti androgenic(1955), anti viral(1960) and anti cancer(1956)(1957)(1958) agent and for treatment of hepatitis B(1960), leukemia(1961), lymphoma(1962), frequent flu and colds(1967),....... by enhancing the functions of Lung, Kidney, Liver, Heart, Spleen, Stomach channels(1943).
Chemical Constituents
Shiitake mushroom is an edible mushroom, genus Lentinula, belongings to family Marasmiaceae, native to East Asia and widely cultivated for consumption for its health benefits and commercial purpose in many Asian countries(1944). The sweet and neural herb has been used in traditional Chinese as anti-inflammatory(1951)(1952), antioxidative(1952)(1953)(1954), immunodulatory(1949)(1950)(1961), anti androgenic(1955), anti viral(1960) and anti cancer(1956)(1957)(1958) agent and for treatment of hepatitis B(1960), leukemia(1961), lymphoma(1962), frequent flu and colds(1967),....... by enhancing the functions of Lung, Kidney, Liver, Heart, Spleen, Stomach channels(1943).
Chemical Constituents
1. Ganodermic acid G
2. Lucidone A
3. Fungal lysozyme
4. Pachymic acid C
5. Stellasterol
6. OPolyporenic acid
7. Pterocarpin
8. Trifolirhizin
9. Kuraridin
10. Kuraridinol
11. Oxalic acid
12. Etc.(1945)
Shiitake mushroom may be the next potential pharmaceutical target in producing a beneficial medicine for treatment of women with PCOs, as the herb has exhibited anti metabolic syndrome(1946) such as, plasma lipid profiles(1963)(1964), fat deposition(1963)(1966), energy efficiency(1963), fasting glucose(1968), insulin sensitve(1947), lipid abnormality(1948), hypertensive(1967)(1969), anti hyperglycaemic(1968)(1969), anti hyperlipidemic(1964)(1965)(1968), weight control(1970), obesity(1966)(1971), through its carbohydrate and lipid metabolism(1965).......induced complications of diabetes(1969)(1971) and cardiovascular disease(1967).
2. Lucidone A
3. Fungal lysozyme
4. Pachymic acid C
5. Stellasterol
6. OPolyporenic acid
7. Pterocarpin
8. Trifolirhizin
9. Kuraridin
10. Kuraridinol
11. Oxalic acid
12. Etc.(1945)
Shiitake mushroom may be the next potential pharmaceutical target in producing a beneficial medicine for treatment of women with PCOs, as the herb has exhibited anti metabolic syndrome(1946) such as, plasma lipid profiles(1963)(1964), fat deposition(1963)(1966), energy efficiency(1963), fasting glucose(1968), insulin sensitve(1947), lipid abnormality(1948), hypertensive(1967)(1969), anti hyperglycaemic(1968)(1969), anti hyperlipidemic(1964)(1965)(1968), weight control(1970), obesity(1966)(1971), through its carbohydrate and lipid metabolism(1965).......induced complications of diabetes(1969)(1971) and cardiovascular disease(1967).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
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(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
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(1944) Popular #Herbs - Shiitake Mushroom by Kyle J. Norton
(1945) Chinese Herbs - Ling Zhi (Ganodermae lucidi) by Kyle J. Norton
(1946) Protective effects of fractional extracts from Panellus serotinus on non-alcoholic fatty liver disease in obese, diabetic db/db mice by Inafuku M1, Nagao K, Nomura S, Shirouchi B, Inoue N, Nagamori N, Nakayama H, Toda T, Yanagita T.(PubMed)
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(1963) Dietary Shiitake Mushroom (Lentinus edodes) Prevents Fat Deposition and Lowers Triglyceride in Rats Fed a High-Fat Diet by Handayani D1, Chen J, Meyer BJ, Huang XF.(PubMed)
(1964) Antihyperlipidemic Effect of Dietary Lentinus edodes on Plasma, Feces and Hepatic Tissues in Hypercholesterolemic Rats by Yoon KN1, Alam N, Lee JS, Cho HJ, Kim HY, Shim MJ, Lee MW, Lee TS.(PubMed)
(1965) Dietary Shiitake Mushroom (Lentinus edodes) Prevents Fat Deposition and Lowers Triglyceride in Rats Fed a High-Fat Diet by Handayani D1, Chen J, Meyer BJ, Huang XF.(PubMed)
(1966) A high-dose Shiitake mushroom increases hepatic accumulation of triacylglycerol in rats fed a high-fat diet: underlying mechanism by Handayani D1, Meyer BJ2, Chen J3, Brown SH4, Mitchell TW5, Huang XF6.(PubMed)
(1967) Lentinus edodes: a macrofungus with pharmacological activities by Bisen PS1, Baghel RK, Sanodiya BS, Thakur GS, Prasad GB.(PubMed)
(1968) Hypoglycemic effect of a Lentinus edodes exo-polymer produced from a submerged mycelial cultur by Yang BK1, Kim DH, Jeong SC, Das S, Choi YS, Shin JS, Lee SC, Song CH.(PubMed)
(1969) Anti-diabetic and anti-hypertensive potential of sprouted and solid-state bioprocessed soybean by McCue P1, Kwon YI, Shetty K.(PubMed)
(1970) The effects of whole mushrooms during inflammation by Yu S1, Weaver V, Martin K, Cantorna MT.(PubMed)
(1971) Protective effects of fractional extracts from Panellus serotinus on non-alcoholic fatty liver disease in obese, diabetic db/db mice by Inafuku M1, Nagao K, Nomura S, Shirouchi B, Inoue N, Nagamori N, Nakayama H, Toda T, Yanagita T.(PubMed)
