Friday, 15 May 2015

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Stress Response and Management herbal Rhodiola

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to  continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                     In Herbal Medicine Perspective

The prevention and management 

Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment  may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
        Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).
 
The stress management herbs

Stress in a natural reaction of human fight or fight response induced by pressure due to such as an environmental condition or a stimulus. Long term stress can cause deleterious and cumulative effects on human body(1104), including emotional or cognitive problems, such as an increased risk of attentional deficit/hyperactivity, anxiety, and language delay(1103), especially for people with chronic illness, including women with Polycystic Ovarian Syndrome (PCOs)(1105).

Rhodiola (Rhodiola rosea) 

Rhodiola Rosea, one of the perennial plant grows in coldest region in the world, including the Arctic, is a genus Rhodiola, belongings to the family Crassulaceae,  used  in traditional medicine as an antiaging(1167) agent, and to treat fatigue(1168)(1169), depression(1170)(1171), anemia(1172), impotence(1173), inflammation(1174), infections(1175), nervous system disorders(1176)(1177), enhance physical endurance(1178), and increase an organism's resistance to stress(1167)(1179).etc.

Phytochemicals(1165)(1166)
1 .Salidroside
2. Sosavin
3. Rosin
4. Sosarin
5. Tyrosol
6. Lignan major compounds in the
7. Heterodontoside,
8. Viridoside
9. Mongrhoside
10. Cyanogenic glucoside rhodiocyanoside A
11. Epigallocatechin and gallate
12 . Epiga
13. Etc.

In an evaluating anti-stress effects, rhodiola rosea, exhibited  positive effects on mental and physical performance under stress(1180)(1181), improved attention and cognitive function associated with its antidepressant activity(1180)(1182) and stress-protective effect of adaptogen(1181), through regulation of nitric oxide (NO) and cortisol levels(1180)(1181).
According to Gesundheitsbezirk Bozen,, rhodiola rosea active substance phenylpropanoide also processed sedative, anti-depressive(1180) and stress-modulated properties through stimulating the distribution of dopamine and serotonin(1182).
In animal model, the herb showed to display antidepressant(1181)(1182)(1184), adaptogenic(1181)(1184), anxiolytic(1184)(1186), nociceptive(1183)(1185) and locomotor activities(1186) induced by intense physical and psychological stress(1183).
In oxidative stress induced animal models, rhodiola is effective in the empowerment of performance(1187), modulation of the immune system(1187) against oxidative damage(1187).
Salidroside (SAL), an active component of Rhodiola rosea protect endothelium(1189) against H2O2-induced endothelial dysfunction(1188)(1189) and oxidative-stress-associated cardiovascular dysfunction(1189) through preventing the overactivation of oxidative stress-related downstream signaling pathways(1188).

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months   


References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed
(1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P1, Vegda R2, Laddha K2.(PubMed)
(1165) Phylogenetic and Phytochemical Characteristics of Plant Species with Adaptogenic Properties by Robyn KLein. CHAPTER 6
(1166) Phytochemical characterization of an adaptogenic preparation from Rhodiola heterodonta by Grace MH1, Yousef GG, Kurmukov AG, Raskin I, Lila MA.(PubMed)
(1167) Rhodiola: a promising anti-aging Chinese herb. by Jafari M1, Felgner JS, Bussel II, Hutchili T, Khodayari B, Rose MR, Vince-Cruz C, Mueller LD.(PubMed)
(1168) Anti-Fatigue Effects of Fermented Rhodiola rosea Extract in Mice by Kang DZ1, Hong HD2, Kim KI3, Choi SY4.(PubMed)
(1169) Rhodiola rosea for mental and physical fatigue in nursing students: a randomized controlled trial by Punja S1, Shamseer L2, Olson K3, Vohra S4.(PubMed)
(1170) Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial by Mao JJ1, Xie SX2, Zee J2, Soeller I3, Li QS3, Rockwell K4, Amsterdam JD5.(PubMed)
(1171) Rhodiola rosea therapy for major depressive disorder: a study protocol for a randomized, double-blind, placebo- controlled trial by Mao JJ1, Li QS2, Soeller I2, Xie SX3, Amsterdam JD4.(PubMed)
(1172) [Effect of salidroside on bone marrow cell cycle and expression of apoptosis-related proteins in bone marrow cells of bone marrow depressed anemia mice]. [Article in Chinese] by Zhang XS1, Zhu BD, Hung XQ, Chen YF.(PubMed)
(1173) Panax ginseng, Rhodiola rosea and Schisandra chinensis by Chan SW1.(PubMed)
(1174) Rhodiola inhibits dengue virus multiplication by inducing innate immune response genes RIG-I, MDA5 and ISG in human monocytes by Diwaker D1, Mishra KP, Ganju L, Singh SB.(PubMed)
(1175) Sambucus nigra extracts inhibit infectious bronchitis virus at an early point during replication by Chen C, Zuckerman DM, Brantley S, Sharpe M, Childress K, Hoiczyk E, Pendleton AR1.(PubMed)
(1176) [Advance in studies on pharmacological effect of salidroside on nervous system diseases]. [Article in Chinese] by Xie H1, Zhu DH.(PubMed)
(1177) Protective effects of a Rhodiola crenulata extract and salidroside on hippocampal neurogenesis against streptozotocin-induced neural injury in the rat by Qu ZQ1, Zhou Y, Zeng YS, Lin YK, Li Y, Zhong ZQ, Chan WY.(PubMed)
(1178) The effects of an acute dose of Rhodiola rosea on endurance exercise performance by Noreen EE1, Buckley JG, Lewis SL, Brandauer J, Stuempfle KJ.(PubMed)
(1179) Effects of plant extracts on the reversal of glucose-induced impairment of stress-resistance in Caenorhabditis elegans by Fitzenberger E1, Deusing DJ, Wittkop A, Kler A, Kriesl E, Bonnländer B, Wenzel U.(PubMed)
(1180) The adaptogens rhodiola and schizandra modify the response to immobilization stress in rabbits by suppressing the increase of phosphorylated stress-activated protein kinase, nitric oxide and cortisol by Panossian A1, Hambardzumyan M, Hovhanissyan A, Wikman G.(PubMed)
(1182) [The interaction of Rhodiola rosea and antidepressants. A case report]. [Article in German] by Maniscalco I1, Toffol E, Giupponi G, Conca A.(PubMed)
(1183) Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice by Perfumi M1, Mattioli L.(PubMed)
(1184) Characterization of the anxiolytic activity of Nunavik Rhodiola rosea by Cayer C1, Ahmed F, Filion V, Saleem A, Cuerrier A, Allard M, Rochefort G, Merali Z, Arnason JT.(PubMed)
(1185) Synergistic interactions between the antinociceptive effect of Rhodiola rosea extract and B vitamins in the mouse formalin test by Montiel-Ruiz RM1, González-Trujano ME, Déciga-Campos M.(PubMed)
(1186) Pharmacological evaluation of Potentilla alba L. in mice: adaptogenic and central nervous system effects by Shikov AN1, Lazukina MA, Pozharitskaya ON, Makarova MN, Golubeva OV, Makarov VG, Djachuk GI.(PubMed)
(1187) Effects of herbal supplements on the immune system in relation to exercise by Megna M1, Amico AP, Cristella G, Saggini R, Jirillo E, Ranieri M.(PubMed)
(1188) Salidroside stimulates mitochondrial biogenesis and protects against H₂O₂-induced endothelial dysfunction by Xing S1, Yang X1, Li W1, Bian F1, Wu D1, Chi J1, Xu G1, Zhang Y1, Jin S1.(PubMed)
(1189) Salidroside improves homocysteine-induced endothelial dysfunction by reducing oxidative stress by Leung SB1, Zhang H, Lau CW, Huang Y, Lin Z.(PubMed)

The best weightloss, weightwatching and healthy recipe: Orange onion salad

Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Recipes contributed by Company's Coming Salads by Jean Pare

Seem an unlikely combination but it is delicious
Large purple onion, sliced   1
Cold water to cover
Large orange, peeled and sliced  2
Cooking oil  1/4 cup (50ml)
Lemon juice 1tbsp.  (15ml)
Salt  1/4 tsp.    ( 1ml)
Oregano  1/4 tsp. (.05ml)
Lettuce  leaves 4 -8
Ripe black olives, sliced (optional) 4
Slice onion thickly. Soaks in cold water 1/2 hour. Drain. peel organs. Sliced crosswise into thin slices. Try for 8 onion slices and 12 orange slices.
Mix cooking oil, lemon juice, salad and oregano. Add onion and orange slices. Marinate 15 minutes.
Put lettuce leaves onto 4 salad plates. Arrange 3 orange and 3 onion slices on top of each. Spoon a bit of marinate over top. Scatter olives over all. Serve 4.
Artichoke salad. Add 14 oz. (398ml) can of drained artichoke. hearts. Toss.


Weight Loss the Easy Ways 
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way

Thursday, 14 May 2015

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Stress Response and Management herbal Rhaponticum

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to  continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                     In Herbal Medicine Perspective

The prevention and management 

Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment  may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
        Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).
 
The stress management herbs

Stress in a natural reaction of human fight or fight response induced by pressure due to such as an environmental condition or a stimulus. Long term stress can cause deleterious and cumulative effects on human body(1104), including emotional or cognitive problems, such as an increased risk of attentional deficit/hyperactivity, anxiety, and language delay(1103), especially for people with chronic illness, including women with Polycystic Ovarian Syndrome (PCOs)(1105).

Rhaponticum or Maral root 

Rhaponticum also known as Maral root, is an herbaceous perennial plant belongings  the family Asteraceae, used in traditional Siberian, Russian and Chinese medicine as anti-depressant(1191)(1192), anti anxiety(1192), anti menopausal complaints(1192)(1193), antioxidant(1194)(1195), immunomodulatory(1194)(1195), anticancerogenic(1194)(1196)(1197), antimicrobial(1194)(1195)(1198)(1199) and adaptogen agent(1194) and to treat impotence(1194), enhance mental and physical performance(1194)(1200), support the nervous(1194)(1201) and cardiovascular system(1194)(1202)(1203), improve work capacity(1194), etc.


Phytochemicals(1190)
1. Rosavin
2. Rosin
3. Rosarin
4. Salidroside
5. Ecdysteroids
6. Flavonoids
7. Phenolic acids
8. Polyacetylenes,
9. Sesquiterpene lactones
10. Triterpenoid glycosides
11. Terpenes
12. Etc.


According to Russian Academy of Medical Sciences, therbal medicne also processed anti metabolic syndrome such as serum lipid profile, corticosterone and cytokine concentrations, glucose tolerance, systolic blood pressure, triacylglycerol accumulation and its induction of inflammation, stress, and hepatic steatosis in rat model(1004).
In in Wistar rats model, N-feruloylserotonins, isolated from the seeds of Leuzea carthamoides (WILLD.) DC, showed effectively in selective stress-reducing effects against stress-sensitive, such as reduced anxiety in the high-pain(1005).
In AdMax formulas, containing  Leuzea carthamoides Iljin, Rhodiola rosea L., Eleutherococcus senticosus Maxim, and from dry berries of Schizandra chinensis Baill, improve response to stimulus and stress, physical endurance and counteract fatigue accordiung to Genext Research, Inc.(1006)



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months   


References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed
(1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P1, Vegda R2, Laddha K2.(PubMed)
(1190) Review Chemistry and pharmacology of Rhaponticum carthamoides: A review Ladislav Kokoska a,*, Dagmar Janovska(Elsevier)
(1191) [The use of a decoction of the rhizome of Leuzea carthamoides for the treatment of alcoholics with depressive states].[Article in Russian] by Ibatov AN.(PubMed)
(1192) Long-term effects of the rhapontic rhubarb extract ERr 731® on estrogen-regulated targets in the uterus and on the bone in ovariectomized rats by Keiler AM1, Papke A, Kretzschmar G, Zierau O, Vollmer G.(PubMed)
(1193) Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors by Vollmer G1, Papke A, Zierau O.(PubMed)
(1194) Chemistry and pharmacology of Rhaponticum carthamoides: a review by Kokoska L1, Janovska D.(PubMed)
(1195) A study on the effect of ethanol extract of Radix rhapontici on erythrocyte immune function in rats by Yan X1, Zhao H, Guan Y, Song Y, Meng J.(PubMed)
(1196) Anticarcinogenic activity of alpha-difluoromethylornithine, ginseng, eleutherococcus, and leuzea on radiation-induced carcinogenesis in female rats by Bespalov VG1, Alexandrov VA, Semenov AL, Kovan'Ko EG, Ivanov SD.(PubMed)
(1197) Subtype-specific activation of estrogen receptors by a special extract of Rheum rhaponticum (ERr 731), its aglycones and structurally related compounds in U2OS human osteosarcoma cells by Möller F1, Zierau O, Jandausch A, Rettenberger R, Kaszkin-Bettag M, Vollmer G.(PubMed)
(1198) Antimycobacterial effect of extract and its components from Rheum rhaponticum by Smolarz HD1, Swatko-Ossor M, Ginalska G, Medyńska E.(PubMed)
(1199) Investigation of the antimicrobial activity of Rhaponticum (Rhaponticum carthamoides D.C. Iljin) and shrubby cinquefoil (Potentilla fruticosa L.).[Article in English, Lithuanian] by Jurkštienė V1, Pavilonis A, Garšvienė D, Juozulynas A, Samsonienė L, Daukšienė D, Jankauskienė K, Simonienė-Kazlauskienė G, Stankevičius E.(PubMed)
(1200) Evaluation of molecular chaperons Hsp72 and neuropeptide Y as characteristic markers of adaptogenic activity of plant extracts by Asea A1, Kaur P, Panossian A, Wikman KG.(PubMed)
(1201) [Cerebroprotector activity of Rhaponticum carthamoides extract in rats with brain ischemia].[Article in Russian] by Plotnikov MB, Logvinov SV, Pugachenko NV, Maslov MIu, Aliev OI, Vasil'ev AS, Suslov NI, Potapov AV.(PubMed)
(1202) [Lipid peroxide, membrane fluidity of smooth muscle cells and atherosclerosis].[Article in Chinese] by Lu YC1(PubMed)
(1203) [Cardioprotective and antiarrhythmic properties of preparations from Leuzea carthamoides, Aralia mandshurica, and Eleutherococcus senticosus].[Article in Russian] by Maslov LN, Guzarova NV.(PubMed)

(1204) Effects of rhaponticum carthamoides versus glycyrrhiza glabra and punica granatum extracts on metabolic syndrome signs in rats by Dushkin M1, Khrapova M, Kovshik G, Chasovskikh M, Menshchikova E, Trufakin V, Shurlygina A, Vereschagin E.(PubMed)
(1205) The selective effect of N-feruloylserotonins isolated from Leuzea carthamoides on nociception and anxiety in rats by Yamamotová A1, Pometlová M, Harmatha J, Rasková H, Rokyta R.(PubMed)
(1206) Influence of the plant extract complex "AdMax" on global gene expression levels in cultured human fibroblast(PubMed)

The best weightloss, weightwatching and healthy recipe: Onion salad

Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Recipes contributed by Company's Coming Salads by Jean Pare

One of the best creamy good extras to serve
Granulated sugar  1/2 cup  (125ml)
Water   1/3 cup  (75 ml)
Vinegar  1/3 cup  (75ml)
Salt  11/2 tsp.  (7 ml)
Spanish onion, sliced and cut up   4
salad dressing (mayonnaise)  1 cup (250ml)
celery seed 1tsp. (5ml)
Combined sugar, vinegar and salt in bowl. Stir sugar until dissolves. Add onion to vinegar mixture. let stand for 3 hours or overnight.
Combine salad dressing with celery seed. Drain onion well. Stir into salad dressing mixture. Serve 8 to 10.
Variation. Use older vinegar instead of white.


Weight Loss the Easy Ways 
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way

Wednesday, 13 May 2015

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Stress Response and Management herbal Licorice

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to  continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                     In Herbal Medicine Perspective

The prevention and management 

Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment  may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
        Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).
 
The stress management herbs

Stress in a natural reaction of human fight or fight response induced by pressure due to such as an environmental condition or a stimulus. Long term stress can cause deleterious and cumulative effects on human body(1104), including emotional or cognitive problems, such as an increased risk of attentional deficit/hyperactivity, anxiety, and language delay(1103), especially for people with chronic illness, including women with Polycystic Ovarian Syndrome (PCOs)(1105).


Licorice

(See herbal treatment of PCOs for more information)
[Gan Cao is also known as Licorice root. The sweet and neutral herb has been used in TCM as anti allergy(856), anti inflammation(855), anti ulcer(857), anti convulsion(858) agent  and to treat stomach weakness, tired and lack of strength, cough with abundance of phlegm, stomach and solar plexus pain, and improve cardiac function(855), etc., as it tonifies the Spleen, benefits the Qi, moistens the Lungs, calms cough, deaf or acute pain, by enhancing all 12 channels(859).
In treatment of PCOs(862), combination of licorice and 100 mg spironolactone showed the activation of the renin-aldosterone system in lowering blood pressure and water (fluid) balance(860). reducing the prevalence of side effects related to the diuretic activity of spironolactone(860). In model rats experiment, Ganshao Paste (CGP), showed the decrease of serum levels of LH, T, and FSH and increase of serum estradiol (E2), and progesterone (P)(861)(865)].

(See The Insulin resistance improvement and/or anti metabolic syndrome herbs: Licorice for more information)
1. PCOs
[ Licorice, in a review of 33 studies of herbal medicine for the management of polycystic ovary syndrome (PCOS), showed a stronge evidences in improved metabolic hormone profile and improved fertility outcomes and  regulation of ovulation and inhibition of hyperandrogenism in PCOS(860). In model rats experiment, Ganshao Paste (CGP), also decreased serum levels of LH, T, and FSH and increased of serum estradiol (E2), and progesterone (P)(861)(860)(865). According to University of Natural Resources and Life Sciences Vienna, licorice may have a potential effect on metabolic syndrome(862) in women with PCOs.

2. Blow flow
Licorice improves the blood flow in the body by exerting its anti thrombosis(983) and inhibiting the levels of bad cholesterol(984)(985) and triglyceride levels(985) and  increasing HDL-cholesterol content(984) in reduced risk of cardiovascular disease(985) and blood stagnation(897) in the abdominal region induced induced infertility(986).

3. Glycyrrhizin
Glycyrrhizin, one of main ingredient from licorice, exhibited anti inflammatory effect pharmacologically in treatment of inflammatory diseases(988)(989)(990), lowered high serum testosterone levels in oligomenorrheic or amenorrheic women, and induced conception in some women(991). As antioxidant, the phytochemical also inhibit irregular cell growth(992)(993) and microbial invasion(994)(995) causes of cancers(992)(993) and infection and inflammation(994)(995) respectively. in adrenocortical function and behavour, it also regulated the levels of cortisol(996), induced by over production of serotonin cause of hormone imbalance(997).

4.  Phytoestrogen
See phytoestrogen in black cohosh
[Phytoestrogen found it balck cohosh showed to occupy the estrogen receptor sites in women body(908), through it antiestrogenic and extrogenic effects(909), to induce hormone balancing may result in improving the chance of ovulation and fertility(910)(911)].

5. Lecithin
Lecithin is a fat like substance called a phospholipid improved lipid transfer, cholesterol efflux, HDL genesis and and remodeling at the blood-brain barrier (BBB)(998). against cells from oxidation surrounding the brain(999), in reducing psychotic symptoms(1002) such as stress(1000)(1001), and depression(1002).
Side effects
1. It may raise blood pressure(1003)(1004(1006)
2. Long term usage of large dosage can also cause edema(1004)(1006) and hypokalemia(1004)(1005)(1006).
3. Overdose can be toxic(106), in inducing rhabdomyolysis or myoglobinuria(1006).
4. Etc.]
Phytochemicals(1058)
1. Glycyrrhizic acid
2. Licochalcone A
3. Licochalcone B
4. Licoflavone
5. Liquiritin
5. Liquiritigenin
7. Isoliquiritigenin
8. Ononins
9. 4′,7-dihydroxyflavone
10. Glycyrrhetinic acid 
11. 11-deoxyglycyrrhetinic acid
12. β-sitosterol
13. Etc.
Licorice's phytochemicals, especially  glycyrrhizin,  have shown efffectively in ameliorated insulin resistance(1059)(1061)(1063)(1064), hyperglycemia(1059)(1060), dyslipidemia(1059)(1063) and oxidative stress(1064) in fructose-induced metabolic syndrome(1059)(1061)(1063) in animal(1059)(1060)(1061)models, probably through its interference of the development of visceral obesity(1064) and cellular derailments that are responsible for the development of metabolic syndrome(1062), anti inflammatory(1062), antioxidant(1062) and an associated with a decrease in tissue lipid deposition(1063) effects].

In chronic unpredictable stress rat model, total flavonoids extract(1153) (licorice flavonoids, LF) and liquiritin(1154), a phyochemical found in locorice exerted anti-depressive(1153)(1154)(1155) and anti-cognitive impairment(1156) property through total flavonoids extract neurogenesis protective effect(1153) and defense of liquiritin and flavonoids extract against oxidative stress(1154)(1156).
Yokukansan, a traditional Japanese formula, containing licorice showed effectively in amelioration of   behavioral symptoms, such as aggressiveness, excitability, and hallucination, through reduced stress  increased the serotonin 2A (5-HT2A) receptors density on the plasma membrane of the prefrontal cortex (PFC)(1158).
In  high-glucose stress, Glabridin(1159)(1160), an isoflavan from licorice root reduced high-glucose stress(1159)(1160) through its anti inflammatory activity(1159), up-regulates manganese superoxide dismutase, catalase and paraoxonase 2(1160).
In anti oxidative stress, licorice showed to contribute to their overall health promoting pharmacological effects against free radicals(1161)(1162)(1163)(1164) induced diseases such as cancer(1161), cardiac dysfunction(1162) liver diosease(1164), etc., through its anti-inflammatory(1161)(1163)(1164), anti-oxidant activities(1161)(1162)(1163)(1164).
According to University of Western Sydney, Glycyrrhiza glabra, one of Chinese herbs, exhibited strong evidences of neuroprotective activity for promotion of healthy ageing and longevity(1157).


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months   


References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed
(1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P1, Vegda R2, Laddha K2.(PubMed)
(1153) [Antidepressant activities of flavonoids from Glycyrrhiza uralensis and its neurogenesis protective effect in rats].[Article in Chinese] by Fan ZZ1, Zhao WH, Guo J, Cheng RF, Zhao JY, Yang WD, Wang YH, Li W, Peng XD.(PubMed)

(1154) Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats by Zhao Z1, Wang W, Guo H, Zhou D.(PubMed)
(1155) Metabonomic study on chronic unpredictable mild stress and intervention effects of Xiaoyaosan in rats using gas chromatography coupled with mass spectrometry by Gao X1, Zheng X, Li Z, Zhou Y, Sun H, Zhang L, Guo X, Du G, Qin X.(PubMed)
(1156) Neuroprotective effects of flavonoids extracted from licorice on kainate-induced seizure in mice through their antioxidant properties by Zeng LH1, Zhang HD, Xu CJ, Bian YJ, Xu XJ, Xie QM, Zhang RH.(PubMed)

(1157) An in vitro study of neuroprotective properties of traditional Chinese herbal medicines thought to promote healthy ageing and longevity by Shen B, Truong J, Helliwell R, Govindaraghavan S, Sucher NJ1.(PubMed)
(1158) Yokukansan, a traditional Japanese medicine, decreases head-twitch behaviors and serotonin 2A receptors in the prefrontal cortex of isolation-stressed mice, by Ueki T1, Mizoguchi K2, Yamaguchi T2, Nishi A2, Sekiguchi K2, Ikarashi Y2, Kase Y2.(PubMed)
(1159) Glabridin, an isoflavan from licorice root, downregulates iNOS expression and activity under high-glucose stress and inflammation by Yehuda I1, Madar Z, Leikin-Frenkel A, Tamir S.(PubMed)
(1160) Glabridin, a phytoestrogen from licorice root, up-regulates manganese superoxide dismutase, catalase and paraoxonase 2 under glucose stress by Yehuda I1, Madar Z, Szuchman-Sapir A, Tamir S.(PubMed)
(1161) Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis by Wu TY1, Khor TO, Saw CL, Loh SC, Chen AI, Lim SS, Park JH, Cai L, Kong AN.(PubMed)
(1162) Licorice treatment prevents oxidative stress, restores cardiac function, and salvages myocardium in rat model of myocardial injury by Ojha SK1, Sharma C1, Golechha MJ1, Bhatia J1, Kumari S2, Arya DS3.(PubMed)
(1163) Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo by Kühnl J1, Roggenkamp D, Gehrke SA, Stäb F, Wenck H, Kolbe L, Neufang G.(PubMed)
(1164) 18-β Glycyrrhetinic acid alleviates 2-acetylaminofluorene-induced hepatotoxicity in Wistar rats: Role in hyperproliferation, inflammation and oxidative stress by Hasan S1, Khan R1, Ali N1, Khan A1, Rehman M1, Tahir M1, Lateef A1, Nafees S1, Mehdi S1, Rashid S1, Shahid A1, Sultana S2.(PubMed)

The best weightloss, weightwatching and healthy recipe: Penny carrots

Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Recipes contributed by Company's Coming Salads by Jean Pare

So versatile, this can be served cold as a salad or relish and also reserve hot. Try it hot over rice.

Carrots, sliced 1/2 inch (12mm) thick, cooked and drained  2 lbs. (1 kg)
Condensed tomato soup 10oz. (284ml)
Granulate sugar 1 cup (250ml)
Vinegar  3/4 cup (175ml)
Cooking oil  1/4 cup (50ml)
Prepared mustard  1tbsp. (15ml)
Medium onion, chopped 1
Green peppers, chopped 2
Combined soup with sugar in medium size saucepan. Add vinegar, oil, mustard, chopped onion and chopped peppers. bring to a boil, stirring frequently. pour over carrots. Chilled covered for 2 days. Serve 12.


Weight Loss the Easy Ways 
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way

Tuesday, 12 May 2015

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Stress Response and Management herbal Ginseng

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to  continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                     In Herbal Medicine Perspective

The prevention and management 

Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment  may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
        Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).
 
The stress management herbs

Stress in a natural reaction of human fight or fight response induced by pressure due to such as an environmental condition or a stimulus. Long term stress can cause deleterious and cumulative effects on human body(1104), including emotional or cognitive problems, such as an increased risk of attentional deficit/hyperactivity, anxiety, and language delay(1103), especially for people with chronic illness, including women with Polycystic Ovarian Syndrome (PCOs)(1105).

Ginseng (Panax spp.)

(See Herbal treatment for PCOs for more information)
[ Ginseng Asia is also known as Panax ginseng. Since it has been grown in the cold places in the Asian, Asian ginseng is considered as yang promoting, according to traditional Chinese medicine.
Korean red ginseng extract (KRGE) in the experiment in PCOs induced rodent, improved PCO-related ovarian dysfunction(830). In rat model, induced by injection of estradiol valerate (EV), the extract also regulated sympathetic nerve activity by significantly lower expression of NGF protein (involved in the growth of peripheral nerve cells) and NGF mRNA(the form of RNA that carries information from DNA) involved in the abnormal process caused by steroid-induced PCO(830). Also, in the experiment of Ginseng total saponins (GTS) involved polycystic ovaries induced by a single intramuscular injection of 4 mg estradiol valerate (EV) in rats, GTS decreased the expression of NGF in ovary tissue(831)].

(See herbal medicine for weight loss)
[Ginseng is a slow-growing perennial plants with fleshy roots, the genus Panax, belonging to the family Araliaceae. Depending to the climate where it grows, ginseng can be classified mainly into Panax ginseng Asian ginseng (root), Red ginseng, wild ginseng, American ginseng (root)(791).
In 10 obese middle-aged Korean women who took Panax ginseng extracts for 8 wk, showed  effectively in influence on gut microbiota in promoting weigh loss but depending to the composition of gut microbiota prior to ginseng intake(792). In mice fed on a high-fat diet, ginseng saponin and ginsenosides not only exerted anti-obesity effects via the modulation of physiological lipid metabolism in vivo or intracellular signalling in cell culture systems, but also promoted anti-obesity effects, through abnormal physiology via HFD. Leptin, insulin, and adiponectin, which carry out critical functions in energy and lipid metabolism(793)].

The Phytochemicals
1. Ginsenoside
2.  Notoginsenoside
3.  Chikusetsuaponin IV
4. Panaxynol
5. Ginsenyne
6. Alpha pansinsene
7. Beta pansinsene
8. Beta farnesene
9. Bicyclogermacrene
10. Beta elemene
11. Gama elemene
12. Alpha neodovene
13. Beta neodovene
14. Alpha humulene
15. Beta humulene
16. Caryophyllene
17. Beta gurjunene
18. Alpha gurjunene
19. Citric acid
20.  Isocitric acid
21.  Fumaric acid
22. Oleic acid,
23. Linoleic acid
24. Beta sitosterol
25. Stigmasterol
26. Daucosterol
27. Sitosteryl-o-(6-O-fatty acyl)-glucpyranoside
28. Etc.

 Panax ginseng, native to Korea, one of most frequent and wonderful used over thousand years in herbal medicine for improvement of male over all health due to aging diminished steroidal hormone in Asian(1138)  has found to process significant anti-stress (1137)(1143)(1144), such as adapt to stress(1138) through reverted cholesterol (CL), creatine kinase (CK) activity(1137)  anti oxidative stress(1139)(1142)(1146) through its elevation in catalase (CAT), and superoxide dismutase (SOD) activities as scavenger enzymes(1139). antioxidant effects(1140).
In immobilized mice, orally administered ginsenoside Rb1 found in Panax ginseng exhibited its anti stress effects through regulation of serum levels of corticosterone(1145) and interleukin (IL)-6(1141). 
In chronic unpredictable mild stress rat model, ginsenosides also ameliorated stress symptoms of depression(1147)(1149)(1150) through significantly suppressed behavioral and biochemical changes(1147) and cognitive impairment, neuroinflammation, and biochemical alterations through improved corticosterone levels; and attenuated oxidative-nitrergic stress(1148).
In stress induced metabolic syndrome(1151), ginseng' saponins (ginsenosides) are proven effectively for its properties of anti-hyperglycemia, insulin sensitization, islet protection, anti-obesity and anti-oxidation in many model systems, according to Louisana State University System(1152).


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months   


References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed
(1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P1, Vegda R2, Laddha K2.(PubMed)
(1103) Antenatal maternal stress and long-term effects on child neurodevelopment: how and why? by Talge NM1, Neal C, Glover V; Early Stress, Translational Research and Prevention Science Network: Fetal and Neonatal Experience on Child and Adolescent Mental Health.(PubMed)
(1104) Immediate and long-term effects of meditation on acute stress reactivity, cognitive functions, and intelligence by Singh Y1, Sharma R, Talwar A.(PubMed)
(1105) The potential implications of a PCOS diagnosis on a woman's long-term health using data linkage by Hart R1, Doherty DA.(PubMed)
(1137) Anti-stress effects of Ginkgo biloba and Panax ginseng: a comparative study by Rai D1, Bhatia G, Sen T, Palit G.(PubMed)
(1138) Ginseng, Korean(The free dictionary by Farlet)
(1139) Effects of Panax ginseng extract on exercise-induced oxidative stress by Kim SH1, Park KS, Chang MJ, Sung JH.(PubMed)
(1140) Saponins from Panax japonicus attenuate D-galactose-induced cognitive impairment through its anti-oxidative and anti-apoptotic effects in rats by Wang T1, Di G, Yang L, Dun Y, Sun Z, Wan J, Peng B, Liu C, Xiong G, Zhang C, Yuan D. (PubMed)
(1141) Anti-stress effects of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol in immobilized mice by Oh HA1, Kim DE, Choi HJ, Kim NJ, Kim DH.(PubMed)
(1142) Protective effect of panax notoginseng saponins on acute ethanol-induced liver injury is associated with ameliorating hepatic lipid accumulation and reducing ethanol-mediated oxidative stress by Ding RB1, Tian K, Cao YW, Bao JL, Wang M, He C, Hu Y, Su H, Wan JB.(PubMed)
(1143) [The anti-stress effect of saponins extracted from panax ginseng fruit and the hypophyseal-adrenal system (author's transl)].[Article in Chinese] by Zhang SC, Jiang XL.(PubMed)
(1144) Ginseng and the hypothalamic-pituitary control of stress by Fulder SJ.(PubMed)
(1145) Stimulation of pituitary-adrenocortical system by ginseng saponin by Hiai S, Yokoyama H, Oura H, Yano S.(PubMed)
(1146) [Study on the mechanism of action of total saponins of Panax notoginseng in ameliorating oxidative stress and insulin resistance in rats fed with high fat diet].[Article in Chinese] by Zhang SS1, Wu ZY2, Chen JM3, Guo QK2, Li L2, Wang ZF2, Gao Y4, Ma ZC4.(PubMed)
(1147) [Effects of ginsenosides on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor in rats exposed to chronic unpredictable mild stress].[Article in Chinese] by Liu L1, Luo Y, Zhang R, Guo J.(PubMed)
(1148) Modulation of nitrergic signalling pathway by American ginseng attenuates chronic unpredictable stress-induced cognitive impairment, neuroinflammation, and biochemical alterations by Rinwa P1, Kumar A.(PubMed)
(1149) Ginsenoside Rb3 exerts antidepressant-like effects in several animal models by Cui J1, Jiang L, Xiang H.(PubMed)
(1150) Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression by Dang H1, Chen Y, Liu X, Wang Q, Wang L, Jia W, Wang Y.(PubMed)
(1151) Role of Endoplasmic Reticulum Stress in Metabolic Disease and Other Disorders by Lale Ozcan and Ira Tabas(PubMed)
(1152) Traditional chinese medicine in treatment of metabolic syndrome by Yin J1, Zhang H, Ye J.(PubMed)