Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Wednesday, 28 January 2015

The best recipe for Diabetes: Leeks in White Wine and Butter

Tuesday, 27 January 2015

#Breakingnews: Natural #remedy efficacy in attenuated #Aging & Photo #AgingSpots & #HyperPigmentation Within 3 Months

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, The Alan Hopkinson Daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com
Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal pharma and Bio science, ISSN 0975-6299.
All right reserved. Reproduction and Translation to other languages of this publication are prohibited without consent of the writer.

Skin aging is one of the most visible aging processes occurred constantly in our skin. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin, and affect skin elasticity and tightness(1).
Dehydroascorbic Acid (DHA) is an oxidized form of vitamin C with Chemical Reaction and Structure as follows

According to Dr. Douglas Q. Kitt, Topical Dehydroascorbic Acid (DHAA) permeates stratum corneum at a rate up to 12 times faster than vitamin C. This supports the concept that lower concentrations of DHAA in topical preparations can enhance skin vitamin C levels with less potential side effects (2).

Liver spots or aging spots are condition of brown or black spots appearing on the surface of the skin due to aging and exposure to ultraviolet radiation from the sun. According to skin care guides, high concentration of Vitamin C may improve the skin and lighten the spots(3). Other articles insisted that liver spots may be the result of a deficiency of vitamin C(4). According to the Duke University Medical Center, the application of topical solutions containing vitamins C and E provided protection for human skin against damage caused by ultraviolet radiation(5)6)(7)(8).

According to Dr. Douglas Q. Kitt, Dehydroascorbic Acid (DHAA) permeates stratum corneum at a rate up to 12 times faster than vitamin C. This supports the concept that lower concentrations of DHAA in topical preparations can enhance skin vitamin C levels with less potential side effects (2).

Our previous study(8) indicated that Dehydroascorbic acid (DHA) 4% may effectively attenuate the roughness, scaliness and get rid off most aging spot and photo aging spots on facial skin in our 24 weeks study through it antioxidants, anti inflammation and free radicals scavenging activities.
Re examination facial skin of patients who continuously apply the formula, after 3 months showed a more profound effectiveness.

Dehydroascorbic acid (DHA) 4% showed effectively in re smoothing 100% and the getting rid of 100% aging and photo aging spots in patients with mild expression and to re smoothing 100% and getting rid of up to 90% aging and photo aging spots in patients with serve expression.

In skin pigmentation, resulted of damage most likely caused by UV sunlight, or unhealthy cells due to aging affecting the production of melanin, dehydroascorbic acid (DHA) 4% induced lightening affected areas up 90% through amelioration of the production of melanin, probably through antioxidants and anti inflammatory pathways as in vitamin C in inhibition of reactive nitrogen species (RNS) including nitric oxide (NO)(9).

Kyle J. Norton, the leading researcher said: " the formula is very easy to make, this discovery may benefits everyone who has tried many types of expensive cosmetic product without success". " The contribution of this discovery may some days induced non existence of aging and photo aging spots
in elders and decreased expression on facial hyperpigmentation".

Since the size of study is small, large example size and multi centers studies are necessary to improve this discovery validation and formula effectiveness, before producing the products in large scales to general public.

The equipment and Preparation 1. One bottle of synthetic vitamin C 100x 500mg tablets. You can purchase this in any pharmacy for about $5.00
2. A small bottle carries 100mL of warm tap water or still-water if desire.
3. A roll of bounty or a half hand size sponge.
4. A pair of plastic glove.

How to make Dehydroascorbic acid (DHA) 4% concentration
Day one
Put 8 tablets of synthetic vitamin C into the bottle which carries 100 mL of water[(8x500mg)/100mL=4000mg/100,000mg=4/100=4% concentration of Dehydroascorbic acid (DHA)] on the day before application to make sure all vitamin C tablets are dissolved.

How to remove Liver and Aging spots and re smooth the facial skin
Liver spot or aging spot is a condition of brown or black spots appeared on the surface of the skin due to aging as the skin is less able to regenerate from sun exposure.
The next day
Put on your glove. Shake the bottle well. Pour some Dehydroascorbic acid (DHA ) onto a piece of fold-twice bounty paper towels. Apply the solution 3 times a days by rubbing against the skin of the effects area with little pressure for about one minutes. Apply more solution if require. Dehydroascorbic acid (DHA) 4% concentration should be able to lighten most of Liver and Aging spots and re smooth some of the skin on the effect areas in a few days.

After applying, clean the sponge if used and glove, return and store the bottle of solution into first aid box in room temperature. Replace the solution every ten days to retain accurate concentration.

What to expect Dehydroascorbic acid (DHA) exhibited its detoxified, antioxidant, lightening and enhanced cell regeneration effects in getting rid of skin damage causes of aging liver and spots and lightening hyperpigmentation due to sun exposure.
1. In the first few days of application
a. Some of liver or aging spots and hyperpigmentation start to lighten
b. Some of the effected skin area start to smooth out
c. Reduction of visibility of the effect areas
2. Within 3 months
Dehydroascorbic acid (DHA) 4% showed effectively in re smoothing 100% in patients with mild and severe expression and getting rid of 90% and 100% aging and photo aging spots respectively in in patients with mild and severe expression and lightening 90% of hyperpigmentation.

Precautions 1. Always testing your topical skin solution, including Dehydroascorbic acid (DHA ) for allergic reaction, by applying a tiny portion onto your wrist for 5 minutes. Do not use the solution if there is allergic reaction.
2. Although there were no adverse effect in our study, please make sure you always wear gloves before applying, as higher concentration of the solution has shown to brownness on the finger nails.
3. The solution has shown to cause yellowness on the surface of some metal (very old) sinks, please make sure your test it to avoid the same messes.
4. Higher concentration of the solution has been used in skin tanning industry, please make the solution is completely absorbed(about 5- 10 minutes) into your skin before going to the extreme sun.
5. If the solution get into your eyes, use tap water to clear them.
6. Do not attempt to make higher solution and put them on your facial skin, as it has not been tested.

If you have any questions, please email me at kylenorton@live.ca

All articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying

References
(1) Skin ageing: natural weapons and strategies by Binic I¹, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(2) Topical Dehydroascorbic Acid (Oxidized Vitamin C) Permeates Stratum Corneum More Rapidly Than Ascorbic Acid by Douglas Q Kitt
(3) Liver Spot Removal: Vitamin C Products(Skin care guide)
(4) Lack of vitamin leads to brown spot on hand(livestrong)
(5) A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation by Murray JC¹, Burch JA, Streilein RD, Iannacchione MA, Hall RP, Pinnell SR.(PubMed)
(6) UV photoprotection by combination topical antioxidants vitamin C and vitamin E by Lin JY¹, Selim MA, Shea CR, Grichnik JM, Omar MM, Monteiro-Riviere NA, Pinnell SR.(PubMed)
(7) Protective effects of topical antioxidants in humans by Dreher F¹, Maibach H.(PubMed)
(8) Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants by Darr D¹, Dunston S, Faust H, Pinnell S.(PubMed)
(9) http://kylejnorton.blogspot.ca/2014/10/anti-skin-aging-in-dehydroascorbic-acid.html
(10) Inhibition of UVA-mediated melanogenesis by ascorbic acid through modulation of antioxidant defense and nitric oxide system. by Panich U¹, Tangsupa-a-nan V, Onkoksoong T, Kongtaphan K, Kasetsinsombat K, Akarasereenont P, Wongkajornsilp A.(PubMed)

(Preview)Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - Treatments in Traditional Chinese Herbal Medicine Radix polygalae(Yuan Zhi)

Diseases of Central Nervous system

Dementia

About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

V. Treatments
C. In traditional Chinese Medicine Perspective(*)According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia.

C.1.2. Radix polygalae(Yuan Zhi)
Yuan Zhi, sweet and slightly cool herb is also known as Thinleaf Milkwort Root, used in TCM as antibiotic property, anti-viral property(732), anti cancer(734) and anti depression(733) agent in treating hepatitis B, tumors in the digestive system, respiratory system and in the uterus, etc., as it calms the heart, transforms phlegm, resolves furuncle and oedema, expel toxin, etc. by enhancing the functions of spleen, lung and liver channels.

Phytochemicals
1. Protein-bound polysaccharide (PSK)
2. Polysaccharopeptides (PSP)
3. Tenuifolin
4. Onjisaponin B
5. Etc.

Yuan Zhi used in the treatment and prevention of dementia(719) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in ameliorated amyloid pathology and related cognitive deficits(735). In aging related dementia, based on the history of use, and pharmacological investigation, Yuan Zhi showed a strong evidence in memory improving, including cholinergic, antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(736). Palmul-chongmyeong-tang, a traditional Chinese medicine formula containing Yuan zhi, exhibited improvement of learning and memory deficits, through reduction of loss of cholinergic immunoreactivity induced by cerebral ischemia(737).

  1. In Alzheimer's disease (AD)
In free radical involved neuro-degeneration in Alzheimer's disease (AD), pretreament with Paeng-Jo-Yeon-Nyeon-Baek-Ja-In-Hwan (PJBH) prescription significantly exhibited cytoprotective effects, through elevating cell survival, antioxidant enzyme activities and resulted decreased production  of malondialdehyde (MDA) which associated to Alzheimer's disease (AD)(738). Smart Soup (SS), composed of Rhizoma Acori Tatarinowii (AT), Poria cum Radix Pini (PRP) and Radix Polygalae (RP), in oral administration of SS ameliorated the cognitive impairment of AD in animal model, effectively reduced Aβ levels, retarded Aβ amyloidosis and reduced Aβ-induced gliosis and neuronal loss(739).

2. In Parkinson's disease
Mutant Huntingtin gene caused by a poly-glutamine expansion in huntingtin( 740)and A53T α-synuclein, a protein found abundantly in the human brain, at the tips of nerve cells (neurons)(741) have shown to be associated with the development of Huntington disease and Parkinson disease. Yuan Zhi phytochemical, onjisaponin B and ethanol extracts showed to induce autophagy(743) through signalling pathway in participation of regulation of vascular function(742) in protection  of cells against pro-neuro apoptosis via the mitochondrial pathway(744). According to colege of Pharmacy and Kyung Hee East-West Pharmaceutical Research Institute, in mouse models of Parkinson's disease, Yuan Zhi also exhibited it protective effects on dopaminergic neurons induced by toxicity(745).

3. In Huntington diseases
Mutant Hungtintin caused of degradation of long-lived cytoplasmic proteins, protein complexes (the gel-like substance enclosed within the cell membrane)(747), or damaged organelles(tiny structures that perform very specific functions within cells)(748) attentuated autophagy in asociateion of the development of Huntington diseases(746), onjisaponin B, found in Yuan Zhi, effectively induce  autophagy through its acceleration of both the removal of mutant huntingtin and and α-synuclein in PC-12 cells(749), which contain mixture of neuroblastic cells and eosinophilic cells(750).

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Reprinted from Norton Journal, Volume I, Most Common Diseases of Ages of 50 Plus - Chapter of Diseases of Central Nervous system(CNS): Dementia - Treatments in Traditional Chinese Herbal Medicine by Kyle J. Norton

Reference
(*) http://www.hindawi.com/journals/ecam/2012/692621/
(732) http://www.ncbi.nlm.nih.gov/pubmed/22205352
(733) http://www.ncbi.nlm.nih.gov/pubmed/20541923
(734) http://www.ncbi.nlm.nih.gov/pubmed/?term=Yuan+zhi+tumors
(735) http://www.ncbi.nlm.nih.gov/pubmed/25386946
(736) http://www.ncbi.nlm.nih.gov/pubmed/21808655
(737) http://www.ncbi.nlm.nih.gov/pubmed/17268076
(738) http://www.ncbi.nlm.nih.gov/pubmed/21808655
(739) http://www.ncbi.nlm.nih.gov/pubmed/25386946
(740) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166352/
(741) http://en.wikipedia.org/wiki/Alpha-synuclein
(742) http://www.nature.com/hr/journal/v33/n5/full/hr201011a.html
(743) http://www.ncbi.nlm.nih.gov/pubmed/24248062
(744) http://www.ncbi.nlm.nih.gov/pubmed/17182613
(745) http://www.ncbi.nlm.nih.gov/pubmed/21195155
(746) http://www.ncbi.nlm.nih.gov/pubmed/18637946
(747) http://en.wikipedia.org/wiki/Cytoplasm
(748) http://www.wisegeek.com/what-are-organelles.htm
(749)http://www.ncbi.nlm.nih.gov/pubmed/?term=Radix+polygalae(+and+Huntinton+disease
(750) http://en.wikipedia.org/wiki/PC12_cell_line

The best recipe for Diabetes: Green Bean with Tomatoes

Monday, 26 January 2015

(Preview)Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - Treatments in Traditional Chinese Herbal Medicine Poria cocos(Fu Ling)

Diseases of Central Nervous system

Dementia

About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

V. Treatments
C. In traditional Chinese Medicine Perspective(*)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia.
C.1. 1. Poria cocos(Fu Ling)
Fu Ling, fu shen or fu ling pi also known as Poria, the bland, sweet and neutral herb has been used in TCM as diuretics(711) and to treat urinary difficulty(711), edema(711), diarrhea(715), emesis(717), vomiting(716), dizziness(716), heart diseases(717)(718), etc., as it eliminates water, strengthens the Spleen, calms the Mind, etc., by enhancing the functions of heart, spleen, lung and kidney channels. The herb has shown to exhibit various biological activities including anti-tumor(713), anti-inflammation(712), immunodepression(712) and antioxidant(711)(713)(714).

Phytochemicals
1. Pachymose
2. Albuninoid
3. Pachymaran
4. B-pachyman
5. B-pachymanase,
6. Pachymic acid,
7. Tumulosic acid,
8. Eburioic acid,
9. Pinicolic acid,
10. Etc.

Fu Ling(720) used for treatment and prevention of dementia(719) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in attenuation of oxidative stress in initiation of neurodegeneration and enhanced neuroprotection(719).

1. Learning and memory impairments
Kyung-Ok-Ko (KOK), the traditional Chine medicine formula, containing Poria cocos, showed effectively in exhibition of its anti-inflammatory effects in protection of brain neuron through attenuating memory(721)(722) and learning impairment(723). In senile dementia, herbal Poria cocos also elicited memory-improving effects in vivo and in vitro through its sinapic acid, tenuifolin, isoliquiritigenin, liquiritigenin, glabridin, ferulic acid antioxidants via cholinergic, antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(722).Yokukansan (TJ-54), another Chinese medicine formula, containing Poria cocos, also inhibited neurological disorders, including dementia and Alzheimer's disease(723) symptoms of memory and behaviors disturbance(724), probably through its anti-cholinesterase activity(725).

2. Cognitive dysfunction
In patients of dementia with cognitive dysfunction, Liuwei Dihuang decoction, containing Poria cocos, showed significantly in attenuated the neural apoptosis, inflammation and Aβ deposition in the hippocampus and cerebral corte(726) causes of cognitive impairment(727) in streptozotocin-induced diabetic rat. In spatial cognition, herbal formula Toki-Shakuyaku-San and fractions of Angelica acutiloba, improved memory and working memory impaired by scopolamine in animal study(728).

3. Alzheimer disease
In mouse model of Alzheimer disease, herbal formula Jangwonhwan, not only showed effectively in ameliorated AD-like pathology, but also exhibited its neuroprotective effects against Abeta-induced cell death, and the Abeta accumulation and plaque deposition in the brain(730), probably through attenuation of reactive oxidative stress(729), by suppressed Aβ-induced apoptosis and ROS production(731).

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Reprinted from Norton Journal, Volume I, Most Common Diseases of Ages of 50 Plus - Chapter of Diseases of Central Nervous system(CNS): Dementia - Treatments in Traditional Chinese Herbal Medicine by Kyle J. Norton

References
(*) http://www.hindawi.com/journals/ecam/2012/692621/
(711) http://www.ncbi.nlm.nih.gov/pubmed/23847967
(712) http://www.ncbi.nlm.nih.gov/pubmed/21347995
(713) http://www.ncbi.nlm.nih.gov/pubmed/24751506
(714) http://www.ncbi.nlm.nih.gov/pubmed/24875321
(715) http://www.ncbi.nlm.nih.gov/pubmed/?term=Poria+cocos+diarrhea
(716) http://www.ncbi.nlm.nih.gov/pubmed/19446542
(717) http://www.ncbi.nlm.nih.gov/pubmed/24933223
(718) http://www.ncbi.nlm.nih.gov/pubmed/15198902
(719) http://www.ncbi.nlm.nih.gov/pubmed/22303969
(720) http://www.ncbi.nlm.nih.gov/pubmed/23433049
(721) http://www.ncbi.nlm.nih.gov/pubmed/22303969
(722) http://www.ncbi.nlm.nih.gov/pubmed/21808655
(722) http://www.ncbi.nlm.nih.gov/pubmed/21305632
(723) http://www.ncbi.nlm.nih.gov/pubmed/20812276
(724) http://www.ncbi.nlm.nih.gov/pubmed/19801831
(725) http://www.ncbi.nlm.nih.gov/pubmed/15500267
(726) http://www.ncbi.nlm.nih.gov/pubmed/24041458
(727) http://www.ncbi.nlm.nih.gov/pubmed/22310556
(728) http://www.ncbi.nlm.nih.gov/pubmed/15351791
(729) http://www.ncbi.nlm.nih.gov/pubmed/20685330
(730) http://www.ncbi.nlm.nih.gov/pubmed/20669372
(731) http://www.ncbi.nlm.nih.gov/pubmed/21762767

The best recipe for Diabetes: Gratin of Swiss Chard Stalk

Sunday, 25 January 2015

(Preview) Most Common Diseases of Ages of 50 Plus - Musculoskeletal disorders (MSDs) - Osteoarthritis: The Preventive Diet

Weight Loss the Easy Ways
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way

If You Are Looking For a SoulMate
Celebrity Patti Stanger Will Coach You To Get Him/Her
and Keep Him/Her for Good,The Simple Way

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs)

Musculoskeletal disorders (MSDs) is medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time.
Most common Musculo-Skeletal Disorders include
1. Musculoskeletal pain .
2. A shoulder disorder
3. rheumatoid arthritis and osteoarthritis (OA) of the hand, hip, and knee.

Types of Musculo-Skeletal disorders in ages of 50 plus(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain

Osteoarthritis

Osteoporosis is condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

1. Green tea
Black tea polyphenol, theaflavin-3,3′-digallate (TFDG) and green tea, epigallocatechin-3-gallate (EGCG) are found to be a lead compounds for the treatment of bone resorption diseases, through inhibition of the formation and differentiation of osteoclasts, according to study.

2. Organic soy
Ingestion soy isoflavone extracts (not soy protein or foods containing isoflavones) supplements increased lumbar spine BMD in menopausal women, but not femoral neck, hip total, and trochanter BMD, according to study.

3. Milk thistle seeds
Silibin found abundantly in Milk thistle seeds has shown to promote bone-forming osteoblastogenesis and encumber osteoclastic bone resorption in vitro cell systems of murine osteoblastic MC3T3-E1 cells and RAW 264.7 murine macrophages.

4. Skin and seed of grape
Resveratrol, a phytohemical of skin and seed of grape promoted spontaneous osteogenesis(bone formation) but prevented adipogenesis(adipocytes in storage of fat) in human embryonic stem cell-derived mesenchymal progenitors, according to study.

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Reprinted from Norton Journal, Volume I, Most Common Diseases of Ages of 50 Plus - Chapter of Musculoskeletal disorders (MSDs) - Osteoarthritis by Kyle J. Norton