Endometriosis: The Effects of Vitamin B3(revised edition with references)

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com
Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

Vitamin B3 , also known as niacin, is a water-soluble vitamin. Besides being usedto treat pellagra caused by dietary lack of vitamin B3 and protein, it also has been known to be effective in treating endometriosis because women with endometriosis are found to have vitamin B3 deficiency. It has a chemical compound formula of C6H5NO2.

1. Hormone synthesis(2)
Vitamin B3 is found to help the manufacturing of hormones such as cortisone and the sex hormones such as  estrogen, progesterone, testosterone, and other steroid hormones in a woman's body. Besides helping to inhibit levels of bad estrogen that causes menstrual cramps during menstrual cycle, it also helps to balance the prostaglandin hormone which causes over-active uterine muscles(1).

2. Digestive system(3)(4)
Deficiency of vitamin B3 is generally found in women with endometriosis during menstruation. It may be caused by the inability of the digestive system in breaking down food particles. Intake of vitamin B3 helps to re-balance the hormones that cause menstrual cramps.

3. Metabolism of carbohydrates(5)(6)(7)
Besides helping to provide energy for our body in metabolism of carbohydrate through bile secretion,

4. Circulatory stimulation(7)
Vitamin B3 also helps in stimulation of the circulatory system by reducing the level of bad cholesterol (LDL) from the arteries in some people.

5. Nervous system(5)
Vitamin B3 is important for the healthy activity of the nervous system by providing the metabolism of protein and fat which are nutrients necessary for brain cells resulting in reduced symptoms of endometriosis such as depression, anxiety, and irritation.

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References
(1) Prostaglandin E₂ is critical for the development of niacin-deficiency-induced photosensitivity via ROS production by Sugita K¹, Ikenouchi-Sugita A, Nakayama Y, Yoshioka H, Nomura T, Sakabe J, Nakahigashi K, Kuroda E, Uematsu S, Nakamura J, Akira S, Nakamura M, Narumiya S, Miyachi Y, Tokura Y, Kabashima K.(PubMed)
(2)Leklem J. E. Vitamin B6. In: Shils M, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore: Williams & Wilkins; 1999:413–422.
(3) http://www.everydayhealth.com/digestive-health/essential-vitamins-for-digestive-health.aspx
(4) Improve your digestive health with these 3 essential vitamins January 28, 2014 by  Dr. Micozzi
(5)Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection by Chi Y¹, Sauve AA.(PubMed)
(6)Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes.by Yang SJ¹, Choi JM, Kim L, Park SE, Rhee EJ, Lee WY, Oh KW, Park SW, Park CY.(PubMed)

(7)Nicotinamide, a glucose-6-phosphate dehydrogenase non-competitive mixed inhibitor, modifies redox balance and lipid accumulation in 3T3-L1 cells.by Torres-Ramírez N¹, Baiza-Gutman LA, García-Macedo R, Ortega-Camarillo C, Contreras-Ramos A, Medina-Navarro R, Cruz M, Ibáñez-Hernández MÁ, Díaz-Flores M.(PubMed)
(8)Niacin inhibits vascular inflammation via downregulating nuclear transcription factor-κB signaling pathway by Si Y¹, Zhang Y², Zhao J³, Guo S², Zhai L², Yao S¹, Sang H¹, Yang N², Song G², Gu J⁴, Qin S².(PubMed)

The Healthy kid Recipe: Sun butter and Jam Pinwheels

Recipes contributed by Good Food to go by Brenda Bradshaw and Cheryl Mutch, MD. published by random house Canada, you can view its website at www.randomhouse.ca

Sunbutter is the brand name of organic sunflower seed butter. This recipe can be made with any seed, soy or nut butter, if your school permits. Prepare thse pinwheel the nigh before and refrigerate over night.
One 8 inch whole wheat soft flour tortilla
2 tbsp. Sunbutter; or other seed, soy or nut butter
1/2 tbsp. fruit-sweetened jam
The night before, spread Sunbutter over tortilla. Spread jam over Sunbutter and roll up. With a sharp night , slice into 1 inch rounds, discarding end. Pack in reusable container and refrigerate over night.
Yield; serve 1 or 2 young children.
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Endoemtriosis: The Effects of Vitamin B2

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com
Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

Vitamin B2 is water soluble, also known as riboflavin. It has a chemical compound formula of C17H20N4O6. Like many other vitamin B complexes, it plays an important role in providing energy to our body by the metabolism of fat, carbohydrates and protein.

1. Red blood cell formation
Vitamin B2 includes the active co-enzyme forms of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) that helps to transport vitamin b2 into the red blood cell as well as maintaining the red blood cell formation(1)

 2. Strengthens the immune system(2)
Vitamin B2 is an antioxidant that helps to rejuvenate the immune system caused by toxins accumulated in the liver that helps to maintain our body's function fighting against any abnormality of cell growth including abnormal endometrial cells(3) and to maintain normal cell division or cell growth which decreases the risk of cell abnormality and prevent endometrial cells to grow somewhere else in the body excluding the endometrium.

3. Migraine(6)(7)(8)
The Riboflavin that is found in Vitamin B2 has shown beneficial results by assisting in decreasing the time as well as the frequency in which one gets a migraine headache due to symptoms of endometriosis during menstruation.

4. Nervous system(4)
Vitamin B2 can assist with alleviating stress as well as reducing symptoms of depression that are brought on by digestive disorders that generally affects women with endometriosis during the menstrual cycle(5).

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References
(1) Covalent attachment of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) to enzymes: the current state of affairs by M. Mewies, W. S. McIntire, and N. S. Scrutton(PubMed)
(2)[Effect of some vitamins on activity of immunocompetent cells].[Article in Russian] by Nezgovorov DV.(PubMed)
(3)An influence of immunomodulation on Th1 and Th2 immune response in endometriosis in an animal model. by Szymanowski K¹, Niepsuj-Biniaś J, Dera-Szymanowska A, Wołuń-Cholewa M, Yantczenko A, Florek E, Opala T, Murawski M, Wiktorowicz K.(PubMed)
(4)Attenuated neuroprotective effect of riboflavin under UV-B irradiation via miR-203/c-Jun signaling pathway in vivo and in vitro by Tripathi AK, Dwivedi A, Pal MK, Rastogi N, Gupta P, Ali S, Prabhu MB, Kushwaha HN, Ray RS, Singh SK, Duggal S, Narayan B, Mishra DP¹.(PubMed)
(5)Estimation of vitamin needs--riboflavin, vitamin B6 and ascorbic acid-according to blood parameters and functional-cognitive and emotional indices in a selected well-established group of elderly in a home for the aged in Israel by Dror Y¹, Stern F, Nemesh L, Hart J, Grinblat J.(PubMed)
(6)Effectiveness of riboflavin in pediatric migraine prevention by Sherwood M¹, Goldman RD.(PubMed)
(7)Riboflavin and migraine: the bridge over troubled mitochondria by Colombo B¹, Saraceno L, Comi G.(PubMed)
(8) Endometriosis is associated with prevalence of comorbid conditions in migraine by Tietjen GE¹, Bushnell CD, Herial NA, Utley C, White L, Hafeez F.(PubMed)

The Weight loss recipe: Fruit and nut oatmeal

Recipe contributed by eat well and lose weight by better Holmesd and Gardens (more than 500 delicious satisfying recipes), published by Houghton Miffin Harcourt. You can view its website at www.hmhbooks.com

In a small saucepan combine 1/2 cup fat free milk and 1/2 cup apple juice, bring to boiling. Stir in 3 dried apricot, diced; 1/2 cup quick cooking rolled oats (not instant); 1/8 teaspoon pumpkin pie spice. Reduce heat/ Simmer 2 minutes or until thickened, stirring constantly. Remove from heat. Cover and let stand for 2 minutes. Sprinkle with 1/2 tablespoon chopped walnuts, toasted.
Per serving, 335 calories, 10 fat (1 g sat. fat) 2mg cholesterol, 54g sodium, 43g carb. 13g sugar, 5g fiber, 12g pro.

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Endometriosis: The Effects of Vitamin B1(*)

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com
Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.

Women with endometriosis are found to have vitamin B complex deficiency during the menstrual cycle. It is not known if it is caused by unhealthy diet or the inability of digestive absorption.
a) Level of estrogen(2)
Vitamin B1 helps to detoxify the liver which may be caused by intake of of alcohol, smoking and heavy metals. A strong liver is particularly important for secretion of cholesterol in breaking down estrogen that causes menstrual cramps as well as hormone balancing in the body(1).
b) Immune system(4)
Vitamin B1 is an antioxidant that helps to strengthen the immune system against the forming of free radicals, endometrial implants, and adhesion somewhere else in the body except the endometrium(3).
c) Red blood cells(5)
Study shows that vitamin B1 helps to normalize the activity of an enzyme called transketolase in red blood cells resulting in increased amounts of the two proteins THTR-1 and RFC-1 which helps to transport thiamine into red blood cells. This increases the production of red blood cells in the bloodstream.
d) Nervous system(6)(9)
It helps to reduce tension of the nervous system as a resulting of converting carbohydrates to energy which is necessary for the proper functions of the nervous system. Thereby it reduces symptoms of endometriosis in some women such as anxiety, depression, and mood swings(7).
e) Intestine muscle tone
Vitamin B1 helps to secrete hydrochloric acid in the stomach which is essential for the complete digestion of food particles and decreases the risk of nutrient deficiency causing hormone imbalance in the menstrual cycle(8)(9)(10).

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References
(*) A prospective cohort study of Vitamins B, C, E, and multivitamin intake and endometriosis.

Darling AM¹, Chavarro JE², Malspeis S³, Harris HR⁴, Missmer SA⁵.(PubMed)

(1) Hepatocyte susceptibility to glyoxal is dependent on cell thiamin content by Shangari N¹, Mehta R, O'brien PJ.(PubMed)
(2) [Action of vitamin B1 on estrogen employed as inhibitors of lactation].[Article in Undetermined Language]by DUMONT M, GUIRAN G.(PubMed)
(3)An influence of immunomodulation on Th1 and Th2 immune response in endometriosis in an animal model by Szymanowski K¹, Niepsuj-Biniaś J, Dera-Szymanowska A, Wołuń-Cholewa M, Yantczenko A, Florek E, Opala T, Murawski M, Wiktorowicz K.(PubMed)
(4)Thiamin function, metabolism, uptake, and transport by Manzetti S¹, Zhang J, van der Spoel D.(PubMed)
(5)Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients(Warwick)
(6)[Effect of diet on distribution of vitamin B1 in sections of the nervous system].[Article in Undetermined Language]by ZAPRUDSKAIA DS.(PubMed)
(7)The social and psychological impact of endometriosis on women's lives: a critical narrative review. by Culley L¹, Law C, Hudson N, Denny E, Mitchell H, Baumgarten M, Raine-Fenning N.(PubMed)
(8)[2 cases of digestive system endometriosis].[Article in French] by Hoyez A, Renaux J, Conreur Y, Van Cauter J, Ligny G.(PubMed)
(9)Chronic pelvic pain in endometriosis: an overview by Triolo O¹, Laganà AS, Sturlese E.(PubMed)
(10)Constipation in patients with thiamine deficiency after Roux-en-Y gastric bypass surgery. by Shah HN¹, Bal BS, Finelli FC, Koch TR.(PubMed)

A tasty Lunch Box: Party Tortilla Wraps

Recipe contributed by Quick and easy family favorites by Vickie and JoAnn
Talk about versatile. These wraps are a great go-to for a tasty appetizer. a special treat for the lunch box or a handy afternoon snack.
8 oz. container chive cream cheese
4(10 inches) flour tortillas
1 Lb. sliced cooked ham
8 oz. pkg. shredded American cheese
Spread cream cheese evenly over tortillas. Place several slices of ham on each tortilla, sprinkle with shredded cheese
Roll up tortillas. Place in refrigerator for 15 minutes. Cut into one-inch piece. make 40 appetizers.

Manly Hardy
Middleville, MI

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Endometriosis: The Affects on women's Emotional state(Revised edition with updated references)

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com
Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

1. Depression
Depression is a illness that not only affects woman with endometriosis but also their family, work or school life, sleeping and eating habits, and general health. It is caused by lower levels of good estrogen and high levels of progesterone, and the symptom get worse before and during menstruation. Being misunderstood by co-workers, family, and friends may trigger the feeling of worthlessness and loss of interest in daily activity such as hobbies and sex(1)(2).

2. Apathy and fatigue
Apathy and fatigue may be caused by thyroid problem or hormone imbalance. Apathy and fatigue in endometriosis is caused by the pressure of coping with any sort of pain that returns relentlessly every month, affecting her physical and emotional state(3).

3. Loss of concentration and memory
Many women with endometrosis also suffer from anemia caused by heavy blood flow leading to deficiency of iron, folate aid, and vitamin B12 which are necessary for reproduction of red blood cells and to increase transportation of oxygen to brain cells, causing loss of concentration and memory. It may be a  result of emotional and social stress(4).

4. Irritability
Irritation besides being caused by hormonal imbalance in the women with endometriosis during the menstrual cycle. Stress and confusion for woman with endometriosis is understandable. It is best to cope with the stress and try understand the disease and how to treat it. Denial of any of this not only causes more emotional pressure but also irritates any suggestion and help(5).

5. Loss of self confidence
It is hard for woman to perform daily activities with menstrual cramps on her back. It not only affects her work but also causes absence due to sickness every month in the work place. Without understanding by her boss and family, women with endometriosis may lose self confidence in her job as well as at home(6).

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 References
(1) [Evaluation of pain and depression in women with endometriosis after a multi- professional group intervention].[Article in Portuguese] by Lorençatto C¹, Vieira MJ, Marques A, Benetti-Pinto CL, Petta CA.(PubMed)
(2) Depression in women with endometriosis with and without chronic pelvic pain by Lorençatto C¹, Petta CA, Navarro MJ, Bahamondes L, Matos A.(PubMed)
(3)The social and psychological impact of endometriosis on women's lives: a critical narrative review by Culley L¹, Law C, Hudson N, Denny E, Mitchell H, Baumgarten M, Raine-Fenning N.(PubMed)
(4) Physical therapy and psychological intervention normalize cortisol levels and improve vitality in women with endometriosis by Friggi Sebe Petrelluzzi K¹, Garcia MC, Petta CA, Ribeiro DA, de Oliveira Monteiro NR, Céspedes IC, Spadari RC.(PubMed)
(5)Prevalence of pain syndromes, mood conditions, and asthma in adolescents and young women with endometriosis by Smorgick N¹, Marsh CA, As-Sanie S, Smith YR, Quint EH.(PubMed)
(6)Diagnostic confidence analysis in the magnetic resonance imaging of ovarian and deep endometriosis: comparison with surgical resultsby Saba L¹, Sulcis R, Melis GB, Ibba G, Alcazar JL, Piga M, Guerriero S.(PubMed)