Cervical cancer in Vitamin K Points of View

Kyle J. Norton

According to the American Cancer Society's, in 2014, 12,360 new cases of invasive cervical cancer will be diagnosed with the death of  4,020 patients. The risk of cervical cancer is higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites(1).
Vitamin K(K1, phylloquinone; K2, menaquinones), is a fat soluble vitamin, found abundantly in leafy green vegetables, broccoli, and Brussels sprouts, etc. It is best known for promotion of coagulation and bone health.

Vitamin K3 (2-methyl-1,4-naphthoquinone), also known as menadione, was found effectively in inhibition of the proliferation of human cervical epithelial cancer cells (HeLa), through binding of tubulin, a small family of globular proteins, including α-tubulin and β-tubulin possible with function of cell division and the movement of materials within cells(1)(2). Other synthetic vitamin K analogue, 2-(2-mercaptoethanol)-3-methyl-1,4-naphthoquinone or compound 5 (Cpd 5) also was found effectively inhibited tumors through arrested cell cycle progression at both G1 and G2-M(3). In cervical carcinoma SiHa cells, Vitamin K3 (VK3)exerted its anti proliferative effects through inhibited cyclin expression via cell cycle arrest and transition of the aphidicolin-synchronised SiHa cells(4)and induced cytotoxicity in human cervical-carcinoma tsgh8302 cells, through exhibited chromatin condensation and DNA fragmentation(5).

Taken altogether, synthetic Vitamin K and its analogue have shown to reduced risk of and treatment of cervical cancer through cell cycle arrest and regulation of cancer cell proliferation. Further studies with large sample size and multi center studies to validate the effectiveness are necessary. Overdoses can induce symptoms of Skin rash,  Diarrhea, Nausea, Vomiting, Anemia, etc. Please make sure you follow the guideline of the Institute of Medicine of the National Academies.



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References
(1)Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity by Acharya BR¹, Choudhury D, Das A, Chakrabarti G.(PubMed)
(2) Mystery of Vital Cell Protein Solved After 30 Years. Receive News Releases Immediately Via E-mail By Lynn Yarris, lcyarris@lbl.gov (Berkeley Lab)
(3) Cdc25 inhibition and cell cycle arrest by a synthetic thioalkyl vitamin K analogue by Tamura K¹, Southwick EC, Kerns J, Rosi K, Carr BI, Wilcox C, Lazo JS.(PubMed)

(3) Vitamin K3 induces cell cycle arrest and cell death by inhibiting Cdc25 phosphatase by Wu FY¹, Sun TP.(PubMed)
(4) Vitamin-k-3 induces cell-death via apoptosis in human cervical-carcinoma tsgh8302 cells by Wu F, Chang W, Sun T.(PubMed)

Salad recipe- Creamy Caesar

Creamy Caesar(Company Coming salads  by Jean Pare)
Caesar dressing
1 garlic clove
1 large egg(or 2 small)
1 tsp.(5 ml) Worcestershire sauces
2 tbsp. (30ml) lemon juice
2 tsp. (10ml) Anchovy paste
Pepper just a dash
1 cup (250ml) cooking oil

Croutons
1 garlic clove. sliced
2 tbsp. (30ml) butter or margarine
4-5 white bread slices, cubed

Salad
1 large head Romaine lettuce
2 cups (500ml) Croutons

8 bacon slices
Cooked and crumbled
Grated Parmesan cheese

Caesar dressing: Put first 6 ingredients into blender. Blend until smooth. With blender running adding cooking oil in a slow stream. Chill about 2 hours.
Crouton: Saute garlic in butter for 2 to 3 minutes. Remove garlic and discard. Add bread cubes. fry until golden, stirring often. remove. Cool
Salad: tear lettuce into bite size pieces in a salad bowl. Add croutons and dressing. Toss to coat.
Sprinkle with bacon and cheese. Serve 6.

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Food Therapy - Button Mushroom and Colon cancer

Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source, It is a genus A. Muscaria and belong to the family Amanitaceae and has been cultivated in many cultures all over the world for foods and health benefits.
Nutrients1. Carbohydrates
2. Protein
3. Thiamine (Vitamin B1)
4. Riboflavin (Vitamin B2)
5. Niacin (Vitamin B3)
6. Pantothenic acid (Vitamin B5)
7. Calcium
8. Phosphorus
9. Potassium
10. Sodium
11. Selenium
12. Iron
13. Copper
14. Zinc
15. Etc.
Chemical constituents
Astraodorol, Psilocybin, Lectin, adustin, ribonuclease, nicotine, 2-hydroxy-4-methoxy-6-methylbenzoic acid, orsellinic acid, melleolide, ergosterol, genistein, daidzein, daucosterol, genistin, uracil and D-mannitol(a).
Button Mushroom and colon cancer
Bowel cancer also known as colorectal cancer, is defined as a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. It is the third most commonly diagnosed cancer in developed countries, including US and Canada.
A. bisporus showed to inhibit colon cancer cell line through positively increased GPx-1 and GPx-2 gene expression and GPx-1 enzyme activity in rat colon, due to the presented selenium(1). the Methodist Research Institute, Indianapolis study showed a positive effect of A. bisporus in inhibition of colon cancer (HT-29, HCT-116) cells, through cell cycle arrest at G0/G1 phase(2) and reversibly inhibits cell proliferation occurred within 30 min of the lectin being bound to the cell surface(3).



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months 

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References
(a) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL¹, Yan LH, Zhang QW, Wang ZM.(PubMed)
(1) Selenium-enriched Agaricus bisporus increases expression and activity of glutathione peroxidase-1 and expression of glutathione peroxidase-2 in rat colon by Maseko T¹, Howell K, Dunshea FR, Ng K.(PubMed)
(2) Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway by Jedinak A¹, Sliva D.(PubMed)
(3) Intracellular trafficking and release of intact edible mushroom lectin from HT29 human colon cancer cells Lu-Gang Yu¹, David G. Fernig² an Jonathan M. Rhodes (The Febs Journal)

Cervical cancer in Vitamin E Points of View

 Kyle J. Norton

According to the American Cancer Society's, in 2014, 12,360 new cases of invasive cervical cancer will be diagnosed with the death of  4,020 patients. The risk of cervical cancer is higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites(1).
Epidemiological studies, linking vitamin E in reduced risk of cervical cancer have not been consistent(1a)(1b)(1c)(1d), but no doubt of its effectiveness in improvement of quality of life, through reduction of oxidative stress(2)(2a)

Vitamin E,  a fat soluble vitamin, consisting eight different variants (alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol) with varying levels of biological activity(3), found abundantly in corn oil, soybean oil, margarine, wheat germ oil, sunflower,safflower oils, etc. plays an important role in neurological functions and inhibition of platelet aggregation, regulation of enzymatic activity, free radical scavenger, etc..

The Universidad Autónoma de Ciudad Juarez study indicated the effectiveness of  dietary supplements, including vitamin E to reduced risk of cervical cancer but depending to the specific factors of the diseases(4)(5). The study from ¹National Cancer Center, of Korea, showed a strong inverse effect of antioxidants vitamin E against risk of cervical cancer in a 144 cervical cancer cases and 288 age-matched, hospital-based controls using unconditional logistic regression models(6). Tocotrienols, variants of vitamin E, including alpha-, beta-, gamma-, and delta-  of palm oil in the testing against human cervical cancer cell line showed a strong effects of alphaT3 and gammaT3  induced cell death.through cell cycle arrest at G2/M phase and triggered apoptosis in  a dose-dependent and time-dependent manner(7).
The Vilnius University study in the assessing the parameters of immune and antioxidant systems in patients with cervical cancer indicated a lower levels of antioxidant vitamin E and the activity of the antioxidant enzyme superoxide dismutase in comparison with the control group(8)(8a). Oral administration of alpha-tocopherol and quercetin, exerted their antioxidants effects in protection of  DNA damage against free radicals through detoxification by increased glutathione and glutathione-s-transferase (9). The study at the University of Colorado Health Sciences Center of three human cancer cell lines, including cervical cancer (HeLa), indicated that d-alpha-tocopheryl succinate (alpha-TS)  induced chromosomal damage in both human cervical cancer cells and ovarian cancer cells, but not in human normal fibroblasts in culture and enhanced the level of radiation-induced chromosomal damage in cancer cells, but it protected normal cells against such damage(10).

Taking altogether, without going into reviews, Vitamin E and its variants may have a protective effect in reduced risk of cervical cancer through its antioxidant properties. But further studies with large sample sizes and multi centers studies are necessary to validate its claims. Over doses of vitamin E supplement can cause symptoms of blurred vision, weakness, dizziness, nausea, diarrhea, etc., please make sure you follow the guideline of the Institute of Medicine of the National Academies.


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References
(1) Cerical cancer (Amerrican cancer society)
(1a) Dietary intakes of selected nutrients and food groups and risk of cervical cancer by Ghosh C¹, Baker JA, Moysich KB, Rivera R, Brasure JR, McCann SE.(PubMed)
(1b) Intakes of selected nutrients and food groups and risk of ovarian cancer by McCann SE¹, Moysich KB, Mettlin C.(PubMed)
(1c) Food consumption pattern in cervical carcinoma patients and controls by Labani L¹, Andallu B, Meera M, Asthana S, Satyanarayana L.(PubMed)
(1d) A case-control study of nutrient status and invasive cervical cancer. I. Dietary indicators by Herrero R¹, Potischman N, Brinton LA, Reeves WC, Brenes MM, Tenorio F, de Britton RC, Gaitan E.(PubMed)
(2)[Effect of antioxidant supplementation over oxidative stress and quality of life in cervical cancer].

[Article in Spanish] by Fuchs-Tarlovsky V¹, Bejarano-Rosales M, Gutiérrez-Salmeán G, Casillas MA, López-Alvarenga JC, Ceballos-Reyes GM (PubMed)

(2a) Alpha-tocopherol and alpha-tocopheryl quinone levels in cervical intraepithelial neoplasia and cervical cancer by Palan PR¹, Woodall AL, Anderson PS, Mikhail MS.(PubMed)

(3) Traber MG. Vitamin E. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins R, eds. Modern Nutrition in Health and Disease. 10th ed. Baltimore, MD: Lippincott Williams & Wilkins, 2006;396-411.
(4) [Dietary supplements as a treatment for cervical cancer: a systematic review].

[Article in Spanish] by Arellano Ortiz AL¹, Jiménez Vega F¹, Salcedo Vargas M².(PubMed)

(5) Vitamin or antioxidant intake (or serum level) and risk of cervical neoplasm: a meta-analysis by Myung SK¹, Ju W, Kim SC, Kim H; Korean Meta-analysis (KORMA) Study Group.(PubMed)

(6) Intakes of vitamin A, C, and E, and beta-carotene are associated with risk of cervical cancer: a case-control study in Korea by Kim J¹, Kim MK, Lee JK, Kim JH, Son SK, Song ES, Lee KB, Lee JP, Lee JM, Yun YM.(PubMed)

(7) Tocotrienols inhibited growth and induced apoptosis in human HeLa cells through the cell cycle signaling pathway by Wu SJ¹, Ng LT.(PubMed)

(8) [Changes in the parameters of immune and antioxidant systems in patients with cervical cancer].

[Article in Lithuanian] by Kazbariene B¹, Prasmickiene G, Krikstaponiene A, Sukeliene D, Burneckis A, Didziapetriene J.(PubMed)

(8a) Plasma concentrations of coenzyme Q10 and tocopherols in cervical intraepithelial neoplasia and cervical cancer by Palan PR¹, Mikhail MS, Shaban DW, Romney SL.(PubMed)

(9) Comparative evaluation of cancer chemopreventive efficacy of alpha-tocopherol and quercetin in a murine model by De S¹, Chakraborty RN, Ghosh S, Sengupta A, Das S.(PubMed)
(10) D-alpha-tocopheryl succinate (vitamin E) enhances radiation-induced chromosomal damage levels in human cancer cells, but reduces it in normal cells by Kumar B¹, Jha MN, Cole WC, Bedford JS, Prasad KN.(PubMed)

Lentil Feta salad

( From The vegetarian collection  by Alison Kent and Canadian living test Chicken)

Prep. 20 minutes, cook 25 minutes, make 6 serving
1/2 cup (125 ml) slivered almond
1 cup (250 ml) dried green lentils, rinsed and drained
2 cloves garlic
1/4 cup (60 ml) extra virgin olive oil
3 tbsp. (45 ml) red wine vinegar
1 tbsp. (15 ml) finely chopped fresh oregano
1/4 tsp. (1ml) each salt and pepper
11/2 cups(375 ml) sliced seeded cucumber
1 cup (250 ml) halved cherry or grape tomatoes
1/2 cup (125 ml) diced sweet or red onion, rinsed and drained
2 tbsp. (30 ml) chopped fresh parsley
3/4 cup (175 ml) crumbled feta cheese

In  small dry skillet, toast almonds over medium heat, stirring often, until golden, about 5 minutes.
Bring large pot of salted water to boil. Add lentils and garlic, reduced heat and simmer until tender about 20 minutes. Drain and rinse in cold water, drain again. Discard garlic.
In large bowl, whisk together oil, vinegar, oregano, salt and pepper. Add lentils, cucumber, tomatoes, onion and parsley, toss to coast.
Stir in almonds and all but 1/4 cup (60ml) of the feta: sprinkle with remaining feta just before serving.



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months 

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Garden Toss

Contributed by
Company Coming salads  by Jean Pare

Refreshing and crisp with a creamy. Contains an excellent mixture
Tiny frozen peas, thawed  1cup   250 ml
Chopped celery   2./3 cup 150 ml
Fined chopped onion  1/4 cup  50 ml
salad dressing (or mayonnaise)  1/2 cup  125 ml
Milk 3 tbsp.  50 ml
Prepared mustard   1/2 tsp.  2 ml
Granulated sugar   1/2 tsp. 2 ml
Salt 1/4 tsp.  1 ml
Pepper 1/16 tsp.  0.5 ml
Head lettuce, cut or torn, lightly packed 4 cups  1L
dark green, such as Romaine or spinach, cut or torn, lightly packed

Combined peas, celery and onion in a large bowl.
Mix next 6 ingredients in a small container. Add to celery mixture. Stir.
Cover and chill until before serving
Add lettuce, dark greens and bacon. Toss to coat. Serve 6.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months 

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Food Therapy - Button Mushroom and Breast cancer

Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source, It is a genus A. Muscaria and belong to the family Amanitaceae and has been cultivation in many cultures all over the world for foods and health benefits.
Nutrients 
1. Carbohydrates
2. Protein
3. Thiamine (Vitamin B1)
4. Riboflavin (Vitamin B2)
5. Niacin (Vitamin B3)
6. Pantothenic acid (Vitamin B5)
7. Calcium
8. Phosphorus
9. Potassium
10. Sodium
11. Selenium
12. Iron
13. Copper
14. Zinc
15. Etc.
Chemical constituents
Astraodorol, Psilocybin, Lectin, adustin, ribonuclease, nicotine, 2-hydroxy-4-methoxy-6-methylbenzoic acid, orsellinic acid, melleolide, ergosterol, genistein, daidzein, daucosterol, genistin, uracil and D-mannitol(a).
Button Mushroom and Breast cancer
Breast cancer (malignant breast neoplasm) is a cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there is also rare cases that breast cancer starts in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.
Dietary intake of with button Mushroom  showed  to protect against breast cancer, but  little effect on the growth of human colon, prostate, gastric cancer, and murine Sarcoma 180 cells(1), may be through ROS-mediated mitochondrial apoptotic pathway(2)
In MCF-7 human breast cancer cells. extract from white button (WB, Agaricus bisporus) mushrooms or water alone (5% v/v), exerted its protective effect with significant suppression of  cellular proliferation(3).



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months 

Back to Researched articles - Points of view of Vitamins, Foods and Herbs
http://kylejnorton.blogspot.ca/p/blog-page_24.html

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References
(a) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL¹, Yan LH, Zhang QW, Wang ZM.(PubMed)
(1) Macrophage immunomodulating and antitumor activities of polysaccharides isolated from Agaricus bisporus white button mushrooms by Jeong SC¹, Koyyalamudi SR, Jeong YT, Song CH, Pang G.(PubMed)
(2) ROS-dependent mitochondria molecular mechanisms underlying antitumor activity of Pleurotus abalonus acidic polysaccharides in human breast cancer MCF-7 cells by Shi X¹, Zhao Y, Jiao Y, Shi T, Yang X.(PubMed)
(2) Commonly consumed and specialty dietary mushrooms reduce cellular proliferation in MCF-7 human breast cancer cells by Martin KR¹, Brophy SK.(PubMed)