Cervical cancer in Vitamin E Points of View

 Kyle J. Norton

According to the American Cancer Society's, in 2014, 12,360 new cases of invasive cervical cancer will be diagnosed with the death of  4,020 patients. The risk of cervical cancer is higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites(1).
Epidemiological studies, linking vitamin E in reduced risk of cervical cancer have not been consistent(1a)(1b)(1c)(1d), but no doubt of its effectiveness in improvement of quality of life, through reduction of oxidative stress(2)(2a)

Vitamin E,  a fat soluble vitamin, consisting eight different variants (alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol) with varying levels of biological activity(3), found abundantly in corn oil, soybean oil, margarine, wheat germ oil, sunflower,safflower oils, etc. plays an important role in neurological functions and inhibition of platelet aggregation, regulation of enzymatic activity, free radical scavenger, etc..

The Universidad Autónoma de Ciudad Juarez study indicated the effectiveness of  dietary supplements, including vitamin E to reduced risk of cervical cancer but depending to the specific factors of the diseases(4)(5). The study from ¹National Cancer Center, of Korea, showed a strong inverse effect of antioxidants vitamin E against risk of cervical cancer in a 144 cervical cancer cases and 288 age-matched, hospital-based controls using unconditional logistic regression models(6). Tocotrienols, variants of vitamin E, including alpha-, beta-, gamma-, and delta-  of palm oil in the testing against human cervical cancer cell line showed a strong effects of alphaT3 and gammaT3  induced cell death.through cell cycle arrest at G2/M phase and triggered apoptosis in  a dose-dependent and time-dependent manner(7).
The Vilnius University study in the assessing the parameters of immune and antioxidant systems in patients with cervical cancer indicated a lower levels of antioxidant vitamin E and the activity of the antioxidant enzyme superoxide dismutase in comparison with the control group(8)(8a). Oral administration of alpha-tocopherol and quercetin, exerted their antioxidants effects in protection of  DNA damage against free radicals through detoxification by increased glutathione and glutathione-s-transferase (9). The study at the University of Colorado Health Sciences Center of three human cancer cell lines, including cervical cancer (HeLa), indicated that d-alpha-tocopheryl succinate (alpha-TS)  induced chromosomal damage in both human cervical cancer cells and ovarian cancer cells, but not in human normal fibroblasts in culture and enhanced the level of radiation-induced chromosomal damage in cancer cells, but it protected normal cells against such damage(10).

Taking altogether, without going into reviews, Vitamin E and its variants may have a protective effect in reduced risk of cervical cancer through its antioxidant properties. But further studies with large sample sizes and multi centers studies are necessary to validate its claims. Over doses of vitamin E supplement can cause symptoms of blurred vision, weakness, dizziness, nausea, diarrhea, etc., please make sure you follow the guideline of the Institute of Medicine of the National Academies.


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References
(1) Cerical cancer (Amerrican cancer society)
(1a) Dietary intakes of selected nutrients and food groups and risk of cervical cancer by Ghosh C¹, Baker JA, Moysich KB, Rivera R, Brasure JR, McCann SE.(PubMed)
(1b) Intakes of selected nutrients and food groups and risk of ovarian cancer by McCann SE¹, Moysich KB, Mettlin C.(PubMed)
(1c) Food consumption pattern in cervical carcinoma patients and controls by Labani L¹, Andallu B, Meera M, Asthana S, Satyanarayana L.(PubMed)
(1d) A case-control study of nutrient status and invasive cervical cancer. I. Dietary indicators by Herrero R¹, Potischman N, Brinton LA, Reeves WC, Brenes MM, Tenorio F, de Britton RC, Gaitan E.(PubMed)
(2)[Effect of antioxidant supplementation over oxidative stress and quality of life in cervical cancer].

[Article in Spanish] by Fuchs-Tarlovsky V¹, Bejarano-Rosales M, Gutiérrez-Salmeán G, Casillas MA, López-Alvarenga JC, Ceballos-Reyes GM (PubMed)

(2a) Alpha-tocopherol and alpha-tocopheryl quinone levels in cervical intraepithelial neoplasia and cervical cancer by Palan PR¹, Woodall AL, Anderson PS, Mikhail MS.(PubMed)

(3) Traber MG. Vitamin E. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins R, eds. Modern Nutrition in Health and Disease. 10th ed. Baltimore, MD: Lippincott Williams & Wilkins, 2006;396-411.
(4) [Dietary supplements as a treatment for cervical cancer: a systematic review].

[Article in Spanish] by Arellano Ortiz AL¹, Jiménez Vega F¹, Salcedo Vargas M².(PubMed)

(5) Vitamin or antioxidant intake (or serum level) and risk of cervical neoplasm: a meta-analysis by Myung SK¹, Ju W, Kim SC, Kim H; Korean Meta-analysis (KORMA) Study Group.(PubMed)

(6) Intakes of vitamin A, C, and E, and beta-carotene are associated with risk of cervical cancer: a case-control study in Korea by Kim J¹, Kim MK, Lee JK, Kim JH, Son SK, Song ES, Lee KB, Lee JP, Lee JM, Yun YM.(PubMed)

(7) Tocotrienols inhibited growth and induced apoptosis in human HeLa cells through the cell cycle signaling pathway by Wu SJ¹, Ng LT.(PubMed)

(8) [Changes in the parameters of immune and antioxidant systems in patients with cervical cancer].

[Article in Lithuanian] by Kazbariene B¹, Prasmickiene G, Krikstaponiene A, Sukeliene D, Burneckis A, Didziapetriene J.(PubMed)

(8a) Plasma concentrations of coenzyme Q10 and tocopherols in cervical intraepithelial neoplasia and cervical cancer by Palan PR¹, Mikhail MS, Shaban DW, Romney SL.(PubMed)

(9) Comparative evaluation of cancer chemopreventive efficacy of alpha-tocopherol and quercetin in a murine model by De S¹, Chakraborty RN, Ghosh S, Sengupta A, Das S.(PubMed)
(10) D-alpha-tocopheryl succinate (vitamin E) enhances radiation-induced chromosomal damage levels in human cancer cells, but reduces it in normal cells by Kumar B¹, Jha MN, Cole WC, Bedford JS, Prasad KN.(PubMed)

Lentil Feta salad

( From The vegetarian collection  by Alison Kent and Canadian living test Chicken)

Prep. 20 minutes, cook 25 minutes, make 6 serving
1/2 cup (125 ml) slivered almond
1 cup (250 ml) dried green lentils, rinsed and drained
2 cloves garlic
1/4 cup (60 ml) extra virgin olive oil
3 tbsp. (45 ml) red wine vinegar
1 tbsp. (15 ml) finely chopped fresh oregano
1/4 tsp. (1ml) each salt and pepper
11/2 cups(375 ml) sliced seeded cucumber
1 cup (250 ml) halved cherry or grape tomatoes
1/2 cup (125 ml) diced sweet or red onion, rinsed and drained
2 tbsp. (30 ml) chopped fresh parsley
3/4 cup (175 ml) crumbled feta cheese

In  small dry skillet, toast almonds over medium heat, stirring often, until golden, about 5 minutes.
Bring large pot of salted water to boil. Add lentils and garlic, reduced heat and simmer until tender about 20 minutes. Drain and rinse in cold water, drain again. Discard garlic.
In large bowl, whisk together oil, vinegar, oregano, salt and pepper. Add lentils, cucumber, tomatoes, onion and parsley, toss to coast.
Stir in almonds and all but 1/4 cup (60ml) of the feta: sprinkle with remaining feta just before serving.



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Garden Toss

Contributed by
Company Coming salads  by Jean Pare

Refreshing and crisp with a creamy. Contains an excellent mixture
Tiny frozen peas, thawed  1cup   250 ml
Chopped celery   2./3 cup 150 ml
Fined chopped onion  1/4 cup  50 ml
salad dressing (or mayonnaise)  1/2 cup  125 ml
Milk 3 tbsp.  50 ml
Prepared mustard   1/2 tsp.  2 ml
Granulated sugar   1/2 tsp. 2 ml
Salt 1/4 tsp.  1 ml
Pepper 1/16 tsp.  0.5 ml
Head lettuce, cut or torn, lightly packed 4 cups  1L
dark green, such as Romaine or spinach, cut or torn, lightly packed

Combined peas, celery and onion in a large bowl.
Mix next 6 ingredients in a small container. Add to celery mixture. Stir.
Cover and chill until before serving
Add lettuce, dark greens and bacon. Toss to coat. Serve 6.


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Food Therapy - Button Mushroom and Breast cancer

Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source, It is a genus A. Muscaria and belong to the family Amanitaceae and has been cultivation in many cultures all over the world for foods and health benefits.
Nutrients 
1. Carbohydrates
2. Protein
3. Thiamine (Vitamin B1)
4. Riboflavin (Vitamin B2)
5. Niacin (Vitamin B3)
6. Pantothenic acid (Vitamin B5)
7. Calcium
8. Phosphorus
9. Potassium
10. Sodium
11. Selenium
12. Iron
13. Copper
14. Zinc
15. Etc.
Chemical constituents
Astraodorol, Psilocybin, Lectin, adustin, ribonuclease, nicotine, 2-hydroxy-4-methoxy-6-methylbenzoic acid, orsellinic acid, melleolide, ergosterol, genistein, daidzein, daucosterol, genistin, uracil and D-mannitol(a).
Button Mushroom and Breast cancer
Breast cancer (malignant breast neoplasm) is a cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there is also rare cases that breast cancer starts in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.
Dietary intake of with button Mushroom  showed  to protect against breast cancer, but  little effect on the growth of human colon, prostate, gastric cancer, and murine Sarcoma 180 cells(1), may be through ROS-mediated mitochondrial apoptotic pathway(2)
In MCF-7 human breast cancer cells. extract from white button (WB, Agaricus bisporus) mushrooms or water alone (5% v/v), exerted its protective effect with significant suppression of  cellular proliferation(3).



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References
(a) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL¹, Yan LH, Zhang QW, Wang ZM.(PubMed)
(1) Macrophage immunomodulating and antitumor activities of polysaccharides isolated from Agaricus bisporus white button mushrooms by Jeong SC¹, Koyyalamudi SR, Jeong YT, Song CH, Pang G.(PubMed)
(2) ROS-dependent mitochondria molecular mechanisms underlying antitumor activity of Pleurotus abalonus acidic polysaccharides in human breast cancer MCF-7 cells by Shi X¹, Zhao Y, Jiao Y, Shi T, Yang X.(PubMed)
(2) Commonly consumed and specialty dietary mushrooms reduce cellular proliferation in MCF-7 human breast cancer cells by Martin KR¹, Brophy SK.(PubMed)
 

Cervical cancer in Vitamin D Points of View

 Kyle J. Norton

According to the American Cancer Society's, in 2014, 12,360 new cases of invasive cervical cancer will be diagnosed with the death of  4,020 patients. The risk of cervical cancer is higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites(a).

Vitamin D is a fat-soluble secosteroids found in small amount in few foods, including salmon, mackerel, sardines and tuna. The vitamin plays an important role in modulation of cellular proliferation, apoptosis induction, tumor growth suppression and promotion in absorption of minerals, including calcium, iron, magnesium, phosphate and zinc.

The Medical Center Bonn Friedensplatz, study showed a preferential risk factor of cancer in patient with low levels of concentration of serum vitamin D, including cervix carcinoma(1). 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), a biologically active metabolite of vitamin D, showed to regulate the growth of various cell types. The expression of VDR, 25-OHase, 1alpha-OHase, and 24-OHase in breast carcinomas (BC), ovarian cancer (OC), cervix carcinomas (CC) might have the ability to synthesize 1alpha,25(OH)2D3 within the cells. Locally in regulating the proliferation and differentiation of the tissues(2). In the study of the same, 25(OH)D3-1alpha-hydroxylase have shown to express in normal cervical tissue, in cervical cancer and in HeLa cells. This local synthesization of 1alpha, 25(OH)2D3 may be significant importance in the regulation of growth control in normal and malignant cervical tissue(3).
In human epithelioid carcinoma cells of cervix HeLa S3K, vitamins D3-induced alkaline phosphatase activity in malignant cells(4).
In a selected 405 incident cervical neoplasias (333 invasive carcinomas and 72 cervical intraepithelial neoplasias grade III (CIN3)) and 2025 age-matched non-cancer controls in Japanese women showed an inverse correction  between dietary calcium and vitamin D intake and cervical neoplasia risk(5).

Taken together, decreased serum of vitamin D might be associated to reduced risk of  cervical cancer. Receptor of vitamin D and its active metabolite of vitamin D may be used to regulation of the cervical cancer tissues. Over doses of vitamin D supplement may cause excessive calcium absorption, calcification, Urinary stones etc. please make sure to follow the guideline of the Institute of Medicine of the National Academies.

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will Personally Coach You How to Get There The Easy Way

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References
(1) Circulating 25-hydroxyvitamin D concentration in German cancer patients by Reinhold U¹, Schmitz B, Kurbacher C, Nagel W, Schmidt M, Malaisse WJ.(PubMed)
(2) Analysis of the vitamin D system in cervical carcinomas, breast cancer and ovarian cancer by Friedrich M¹, Rafi L, Mitschele T, Tilgen W, Schmidt W, Reichrath J.(PubMed)
(3) Analysis of 25-hydroxyvitamin D3-1alpha-hydroxylase in cervical tissue by Friedrich M¹, Villena-Heinsen C, Axt-Fliedner R, Meyberg R, Tilgen W, Schmidt W, Reichrath J.(PubMed)
(4) Effect of vitamin D3 and 1,25(OH)2D3 on growth of neoplastically derived cell lines and their alkaline phosphatase activity by Kholodova YuD¹, Bondar OP, Melnykovych G.(PubMed)

(5) Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women by Hosono S¹, Matsuo K, Kajiyama H, Hirose K, Suzuki T, Kawase T, Kidokoro K, Nakanishi T, Hamajima N, Kikkawa F, Tajima K, Tanaka H.(PubMed)

Food therapy - Mushroom and Ovarian cancer

Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source, It is a genus A. Muscaria and belong to the family Amanitaceae and has been cultivation in many cultures all over the world for foods and health benefits.
Nutrients 
1. Carbohydrates
2. Protein
3. Thiamine (Vitamin B1)
4. Riboflavin (Vitamin B2)
5. Niacin (Vitamin B3)
6. Pantothenic acid (Vitamin B5)
7. Calcium
8. Phosphorus
9. Potassium
10. Sodium
11. Selenium
12. Iron
13. Copper
14. Zinc
15. Etc.
Chemical constituents
Astraodorol, Psilocybin, Lectin, adustin, ribonuclease, nicotine, 2-hydroxy-4-methoxy-6-methylbenzoic acid, orsellinic acid, melleolide, ergosterol, genistein, daidzein, daucosterol, genistin, uracil and D-mannitol(a).


1. Button Mushroom and Ovarian cancer
Ovarian cancer is defined as a condition of abnormal cells growth of ovarian cells as that have become cancerous. It is one of most common cancer in US, according to the statistics adapted from the American Cancer Society's publication, Cancer Facts & Figures 2010, an estimated 21,880 women in the United States will be diagnosed with ovarian cancer and 13,850 deaths.
button mushrooms (Agaricus bisporus), in scientific literature suggests that dietary components may exert cancer preventive effects(1). According to the Curtin University and National Institute of Hygiene and Epidemiology, Hanoi, Vietnam, high levels of intake mushroom is associated to  reductions in cancer risk, especially in the incidence of epithelial ovarian cancer in southern Chinese women, in the study of 500 incident patients with epithelial ovarian cancer and 500 controls(2), But some researchers concerned that minerals of nutritional value are common constituents of mushrooms collected from natural habitats, the problem is however their co-occurrence with some hazardous elements including Cd, Pb, Hg, Ag, As, and radionuclides(3).



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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months 

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References
(a) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL¹, Yan LH, Zhang QW, Wang ZM.(PubMed)
(1) The cancer preventive effects of edible mushrooms by Xu T¹, Beelman RB, Lambert JD.(PubMed)
(2) Mushroom intake and risk of epithelial ovarian cancer in southern Chinese women by Lee AH¹, Pasalich M, Su D, Tang L, Tran VD, Binns CW.(PubMed)
(3) Macro and trace mineral constituents and radionuclides in mushrooms: health benefits and risks. by Falandysz J¹, Borovička J.(PubMed)

Spiced chili nuts and seeds

 Recipe contributed by Fresh and Easy Meals by Better Homes and Gardens

Pick your favorite nuts and seed for this snack recipe. Orange juice concentration spiked with piquant spices gives the mixture a burst of favor.

Prep. 10 minutes
Bake 15 minutes
Oven 300 degrees F
Make 16 (1/4 cup) serving

2 tsp. frozen orange juice concentrate thawed.
2 tsp. Worcestershire sauce
1 tsp. garlic powder
1 tsp ground cumin
1 tsp chili powder
1/2 tsp. cayenne pepper
1/4 tsp salt
1/4 tsp. ground allspice
1.4 esp onion salt
2 cups unsalted peanuts, hazelnuts, and/or Brazil nuts
1 cup peacan halves
6 tsp.unsalted shelled sunflower seeds
2 tsp. sesame seeds
Non stick cooking tray

In a large bowl, combined orange juice concentrate, Worcestershire sauce, garlic powder, cumin, chili powder, cayenne pepper,salt, allspice, black pepper and onion salt. Stir in nuts and seeds; toss to coat.
Line a 15x10x1 inch baking pan with foil; slightly coat with nonstick cooking spray. Spread nuts and seed on foil. Bake in a300 degrees oven for 15 to 20 minutes or until toasted, stirring once. Cool. Store in an airtight container at room temperature for up to 1 week.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months 

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Nutrition facts per serving: 186Cal, 16 g total fat(2 g sat. fat), 0mg cholesterol, 59 sodium, 7 g carbo, 3 g fiber, 6 g pro.
daily value: 2% vitamin A, 6% vitamin C, 2% calcium, 5% iron.