#Sulforaphane Found in #Broccoli Slows the Progression of Hepatic Lipidosis Associated with #LiverDiseases, Researchers Show

Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing it to other parts of the body.

The liver also produces cholesterol, a waxy substance that aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Liver disease is a class of medical conditions characterized by reducing partly or completely the function of the liver, including liver failure.


A fatty liver is a liver condition associated with the accumulation of excess fat in the liver.

Non-alcoholic fatty liver (NAFL) is the early stage of nonalcoholic steatohepatitis (NASH) caused by the accumulation of fat in the liver, other than excessive use of alcohol.

Nonalcoholic steatohepatitis (NASH) is a type of inflammatory non-alcoholic fatty liver disease caused by excessive fat accumulated in the liver.

Nonalcoholic steatohepatitis (NASH) is asymptomatic until the condition is developed into cirrhosis, the condition that causes advanced liver scars, and reduces the performance of the liver.

In other words, if more than 5% – 10% percent of your liver’s weight is fat, you have a fatty liver (steatosis).
The prevalence rate of non-alcoholic fatty liver disease (NAFLD) among the more affluent regions of China, is approximately 15%. The number may decrease substantially if the poor rural populations where obesity is non-existence are also taken into account.

In the US, over 100 million people have non-alcoholic fatty liver disease and the condition has doubled over the past 20 years. Today, the disease is also prevalent in liver disease in children.

Most people at the early stage of NAFLD are asymptomatic. However, as the disease progresses into the later stage, most patients experience symptoms of right upper abdominal discomfort, fatigue, and/or malaise, and jaundice(20) with yellowing of the skin and eyes.

Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

To find a natural food for the prevention and treatment of liver diseases, researchers examined the effect of dietary broccoli protects against fatty liver development.

The study included male 15-day-old C57BL/6J mice that were given DEN and placed on a Western or Western+10% Broccoli diet from the age of 4 weeks through 7 months. before exposure to the hepatocarcinogen diethylnitrosamine (DEN).

According to the results of the analysis,* Dietary broccoli decreased hepatic triacylglycerols, NAFLD, liver damage, and tumor necrosis factor by month 5 without changing body weight or relative liver weight induced by hepatocarcinogen diethylnitrosamine (DEN).

* However, broccoli feeding did not have low liver carcinogenesis, observed in 100% of tested mice.

Based on the results, researchers wrote, " We conclude that broccoli, a good source of sulforaphane, slows the progression of hepatic lipidosis, but not tumourigenesis in this robust model".

Taken together, broccoli may be considered functional food for the prevention of fatty liver, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary broccoli protects against fatty liver development but not against progression of liver cancer in mice pretreated with diethylnitrosamine by Chen YJ1, Myracle AD1, Wallig MA2, Jeffery EH. (PubMed)

#Herbal #Turmeric Improves Parameters Associated with the Risk of Metabolic Syndrome, Researchers Show

Kyle J. Norton

Metabolic syndrome is a cluster of conditions that increase the risk of heart disease, stroke, and diabetes, including too much fat around the waist, high blood pressure, triglycerides, and blood sugar, and low HDL cholesterol.
People who have 3 or more aforementioned conditions are at a higher risk of heart disease, stroke, and diabetes. However, most people with metabolic syndrome have never developed cardiovascular disease (CVD) or diabetes.

Most common symptoms of metabolic symptoms are depending totally on the clustered conditions, including thirst and urination, fatigue, and blurred vision due to high blood glucose. However, in patients with no condition of hyperglycemia, metabolic syndrome is asymptomatic.

Epidemiologically, aging, ethnicity, obesity, medical condition such as diabetes, nonalcoholic fatty liver disease, and polycystic ovary syndrome are most risk factors found in patients with the syndrome.

Conventionally, the treatment of metabolic syndrome is totally depending on the cluster of condition. People with fat around the waist or obese are recommended to lose weight in a weight management program accompanied by diet change.

Some researchers suggested that the promotion of the Western diet in the US over the past few decades may have a strong effect in inducing the widespread metabolic syndrome.

Dr. Drake I, the lead scientist wrote, "The 'Western' dietary pattern was inversely associated with HDL-cholesterol and positively with all other response variables (both at baseline and follow-up), but there was no association with LDL at follow-up".

And, " In conclusion, this study supports current food-based dietary guidelines suggesting that a 'Western' dietary pattern with high intakes of sugar-sweetened beverages and red and processed meats and low intakes of wine, cheese, vegetables, and high-fiber foods is associated with detrimental effects on cardio-metabolic health".

The results clearly suggested if you are following a traditional diet with high fruits and vegetables and fewer in processed food, saturated and trans fat, and red meat accompanied with moderate exercise daily, your risk metabolic syndrome can be decreased substantially.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In finding a potential compound that processes an anti-metabolic syndrome activity, researchers examined the Black seeds and Turmeric alone and its co-administration in lower doses among patients with metabolic syndrome (MetS).

The double-blind-randomized-controlled trial included a total of 250 healthy males with MetS randomized to either Black seeds (1.5g/day), Turmeric (2.4g/day), its combination (900mg Black seeds and 1.5g Turmeric/day) or placebo for 8 weeks.

Based on the analysis, compared to the baseline, at 4 weeks, Black seed and Turmeric alone showed improvement in the parameters associated with the risk of MetS including the body-mass-index (BMI), waist circumference (WC), and body-fat-percent (BF%).


Furthermore, also at week 4, the combination improved all parameters involved in the risk of MetS, except HDL-cholesterol with lower fasting blood glucose (FBG) and LDL-cholesterol, compared to placebo.

Moreover, at 8 weeks, Black seeds reduced lipids and FBG, whereas turmeric reduced LDL-cholesterol and CRP, compared to placebo.

More importantly, the combination group with a 60% dose of the individual herbs showed an improvement in all parameters from baseline, compared to placebo.

In other words, the combination showed complete inhibition of all parameters associated with the onset of metabolic syndrome compared to the selected inhibition of individual herbal medicine. Black seeds + Turmeric showed much better efficacy than the use of Black seed and Turmeric alone.


Based on the results, researchers said, " The combination of Black seeds and Turmeric can, therefore, be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be used alone or combination with Black seed for the prevention and treatment of metabolic syndrome, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome - a double blind randomized controlled trial - TAK-MetS trial by Amin F1, Islam N2, Anila N3, Gilani AH. (PubMed)
(2) Coadministration of black seeds and turmeric shows enhanced efficacy in preventing metabolic syndrome in fructose-fed rats by Amin F1, Gilani AH, Mehmood MH, Siddiqui BS, Khatoon N. (PubMed)
(3) A Western dietary pattern is prospectively associated with cardio-metabolic traits and incidence of the metabolic syndrome by Drake I1, Sonestedt E1, Ericson U1, Wallström P2, Orho-Melander M. (PubMed)

#Fennel Protects the Liver Against Toxicity, According to Studies

Kyle J. Norton

Fennel may be considered a functional food in exhibited liver protective effect against toxicity, some scientists suggested.
Liver protection is an action that prevents injury and damage to the liver, regardless of the causes.

Researchers do not know the exact cause of liver disease. However, they do know that genes inherited from the parents, aging, and viral and bacterial infection are associated with the increased risk of liver disease.

Additionally, long-term excessive alcohol drinking and obesity are also some prevalent risk factors for the onset of liver disease.

Untreated liver disease or liver disease that is not treated properly over time can increase the risk of cirrhosis, a leading cause of liver failure and a life-threatening condition.


Dr. William Nseir, the lead author in the assessment of the role of diet and lifestyle changes in nonalcoholic fatty liver disease wrote, "A combination of dietary modifications and increased physical activity remains the mainstay of NAFLD management. It is hard to maintain this mode of management; however, it seems to have significant long-term benefits" "Furthermore, NAFLD patients, whether obese or not, should be educated that a healthy diet and physical activity have benefits beyond weight reduction".

These results suggested that a change in diet and lifestyle with moderate exercise may have a strong effect on the prevention of liver disease.

Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.

The herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, and antidepressant agent and nd to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...

In the evaluation of the liver protective effect against acute hepatotoxicity induced by carbon tetrachloride (CLL4) in the rat model, researchers found that oral administration of essential oil isolated from the fennel exerts a strong activity in the decrease of levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and bilirubin, the potential causes of liver damage through their toxic effects.

Further analysis insisted that the hepatoprotective activity of the essential oil was attributed to the expression of phytochemical constituents d-limonene and β-myrcene in the inhibition of the levels of carbon tetrachloride in catalyzing liver toxicity and initiating liver lesion and liver fibrosis.

Additional differentiation of the hepatic fibrosis model in rats induced by subcutaneous injection with 40% CCl4 olive oil mixture with 94 male SD rats given high lipoid-low protein animal feeds for 5 weeks then randomly divided into six groups, including blank control group (A-group), 8 rats was feed in normal, prevention model control group (B-group), 10 rats given saline solution by intragastric administration during the make of hepatic fibrosis model and FVM prevention group (C-group), 10 rats given FVM by intragastric administration during the make of hepatic fibrosis model; model control group (D-group), FVM treatment group (E-group) and Fuzhenghuayu treatment group (F-group), after assessing the results from the 5-th weekend, A, B, C- group rats sacrificed at the 6-th, 7-th, 8-th, 9-th weekend and 4-6 rats in D, E, F-group sacrificed., researchers indicated that

* The expression of alpha-smooth muscle actin(a-SMA) associated with liver damage and correlated positively in the recurrent HCV hepatitis group is significantly higher in the HBV cirrhosis detected by immunohistochemical staining assay.

* Serum alanine aminotransferase (ALT), an amino acid found in proteins and intermediate in cellular energy production presented in the blood of tested subjects may be an indication of liver damage.

Low levels of ALT are found in the blood profiles of healthy individuals.
* Similar to ALT, aspartate aminotransferase (AST) is an enzyme associated with the liver parenchymal cell and presented in low levels in the blood of healthy individuals but significantly higher in liver damage tested rats.

* Hyaluronic acid (HA) is distributed widely throughout connective, epithelial, and neural tissues, the prediction of liver damage, particularly in the risk of liver fibrosis.

* Increased levels of Laminin (LN), a protein of the extracellular matrix, is also associated with a substantial risk of the development of liver fibrosis.


* Overexpression of levels of 8 - hydroxy-2-deoxyguanosine (8-OHdG) is another indication of oxidative stress and is also considered a critical biomarker of carcinogenesis.

The increased levels of the above expressions suggested substantial damage to the liver caused by ingestion of CCL4 in the non-fennel treatment group
However, application of fennel in such groups inhibited the overexpression of toxicity caused by the injection of CCL4 by restoring the normal levels of Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), laminin (LN) and 8 - hydroxy-2-deoxyguanosine (8-OHdG).

Further analysis also showed that oral administration of fennel inhibited the levels of malondialdehyde (MDA) in precipitated oxidative stress through lipid peroxidation.

Some researchers suggested that levels of MDA may be used as a biomarker in the assessment of oxidative stress status in patients with liver disease or cancer.

Moreover, injection of fennel exerted liver protective and anti-inflammatory effects through its antioxidants overexpression and improved production of natural antioxidants in the host tissue such as superoxide dismutase (SOD), glutathione peroxidase levels in inhibited oxidative stress initiated by CCL4

Precisely, fennel significantly decreased expression serums of ALT, AST, HA, LN and MDA, 8-OHdG, fiber, and a-SMA expression in the FVM group and lowered inflammation grade and fibrosis stage compared to the control group.


Dr. Zhang ZG, the lead author, after taking into account other co-founders said, "Foeniculum Vulgare Mill declines liver inflammation response, and prevents the hepatic fibrosis progression,, this may be due to its effects of antioxidative results".

The findings suggested that fennel with abundant bioactive anethole may be considered a functional food in exhibited hepatoprotective effect through its anti-inflammatory and antioxidant activities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shortShorty Awardy award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Hepatoprotective effect of Foeniculum vulgare essential oil by Ozbek H1, Uğraş S, Dülger H, Bayram I, Tuncer I, Oztürk G, Oztürk A.(PubMed)
(2) [Antioxidant effects of the Uygur herb, Foeniculum Vulgare Mill, in a rat model of hepatic fibrosis].[Article in Chinese] by Zhang ZG1, Lu XB, Xiao L, Tang L, Zhang LJ, Zhang T, Zhan XY, Ma XM, Zhang YX(PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)

#Betanin Increases the Expression of an Enzyme Associated with Detoxification Against the Onset of Liver Damages, Researchers FInd

Kyle J. Norton

The liver is the largest internal organ that not only filters the blood coming from the intestinal system but also protects our body against chemical and drug toxicity.

Additionally, the liver also produces cholesterol that plays an essential role in aiding digestion, producing vitamin D and steroid hormones, and building strong cell membranes.

Believe it or not, the liver also produces antioxidant enzymes that inhibit free radical oxidation and interact with the hormone insulin to store glucose in the form of glycogen.

Hepatic steatosis is a condition caused by the accumulation of fat in the liver. Liver steatosis can be classified into 2 types

* Alcoholic liver steatosis is caused by over-consumption of alcohol over time.

* Non-alcohol steatosis (NASH) is a condition of accumulation of excess fat in the liver in people who drink little or no alcohol. ... Non-alcohol steatosis is considered a major cause of liver scarring and cirrhosis.

The most common symptoms of liver steatosis are jaundice, abdominal swelling (ascites), enlarged blood vessels just beneath the skin's surface, enlarged breasts in men, enlarged spleen and red palms.

If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.

Conventionally, there is no effective treatment for liver steatosis. Weight loss and weight management through a combination of a healthy diet and exercise are the most recommendations.

Some researchers suggested that the rise of liver steatosis in the US may be correlated to the promotion of a high-fat diet over the past few decades.

Dr. Arisqueta L, the lead scientist wrote, "High-fat diet (HFD) feeding or leptin-deficient mice are extensively used as models resembling features of human nonalcoholic fatty liver disease (NAFLD)".

And, "The concurrence of experimental factors as fat content and source or total caloric intake leads to prominent differences in the development of the hepatic steatosis and related disturbances".

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.

In finding a natural pigment for the prevention and treatment of liver steatosis, researchers examined whether betanin (from natural pigments, a member of betacyanins) had anti-oxidant properties against paraquat-induced liver injury in Sprague-Dawley rats.

Paraquat injected intraperitoneally into rats to induce liver toxicity and randomly assigned to 4 groups: a control group, a paraquat group, and two groups received betanin at doses of 25 and 100mg/kg/day three days before and two days after administered paraquat.

Administration of betanin inhibited the elevated serum aspartate aminotransferase and alanine aminotransferase levels of the paraquat rats.

Betanin treated group also enhanced the production of antioxidant enzymes that counter the overexpression of free radicals-induced oxidative stress.

Furthermore, the betanin-treated group also increased the expression of an enzyme associated with detoxification.

Moreover, liver mitochondrial damage caused by paraquat injection also was reduced by the administration of betanin.

In other words, all parameters associated with the onset of liver damage that causes steatosis to develop were decreased substantially in the animals treated with betanin than in those who received paraquat alone.

Based on the results, researchers after taking other factors into account wrote, "Betanin had a protective effect against paraquat-induced liver damage in rats. The mechanism of the protection appears to be the inhibition of CYP 3A2 expression and protection of mitochondria".

Taken altogether, betacyanins processed abundantly bioactive ingredient betanin may be considered a remedy for the prevention and treatment of liver steatosis, pending the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Red pitaya betacyanins protect from diet-induced obesity, liver steatosis, and insulin resistance in association with modulation of gut microbiota in mice by Song H1,2, Chu Q1, Yan F1, Yang Y1, Han W1, Zheng X. (PubMed)
(2) White Pitaya (Hylocereus undatus) Juice Attenuates Insulin Resistance and Hepatic Steatosis in Diet-Induced Obese Mice by Song H1,2, Zheng Z1, Wu J1, Lai J1, Chu Q1, Zheng X. (PubMed)
(3) High-fat diet overfeeding promotes nondetrimental liver steatosis in female mice by Arisqueta L1, Navarro-Imaz H2, Labiano I3, Rueda Y2, Fresnedo O. (PubMed)

#Healthyfood #WhiteButtonMushroom Inhibits the Risk of Fatty Liver Disease, According to Studies

Kyle J. Norton

White button mushrooms may have a protective effect against the onset and treatment of nonalcoholic liver disease, some scientists suggested.
Fatty liver or hepatic steatosis is a disease caused by the buildup of fat in the liver. If the fat in your liver is over 5 percent proportional to the liver cells, you are considered to have the early stage of fatty liver disease.

According to the American liver foundation, the fatty liver is the most common disease in the US, affecting over affecting around 25 % of the population. The disease is most common in the age group between 40 and 60.

The common diseases associated with the onset of the nonalcoholic fatty liver disease include obesity hyperlipidemia, or high levels of fats in the blood, especially high triglycerides, diabetes, and genetic inheritance.


However, some researchers also found that long-term use of certain medications is the prevalent risk factor for fatty liver such as rapid weight loss side effects of certain medications, including methotrexate (Trexall), tamoxifen (Nolvadex), amiodarone (Pacerone), and valproic acid (Depakote).

Can the nonalcoholic fatty liver disease be prevented? Dr. William Nseir, the lead author in the study " Role of diet and lifestyle changes in nonalcoholic fatty liver disease", wrote, "there is no drug therapy that can be formulated for treating NAFLD. A combination of dietary modifications and increased physical activity remains the mainstay of NAFLD management" and


"NAFLD patients, whether obese or not, should be educated that a healthy diet and physical activity have benefits beyond weight reduction".


The result suggested that if you have followed a healthy diet high in fruits and vegetables, whole grains, and low in saturated and trans fat, red meat, and processed food and lifestyle accompanied by moderate exercise, your risk of nonalcoholic fatty liver disease is closed to zero.


If you are experiencing the symptoms of a persistently enlarged fluid-filled abdomen, jaundice of the skin and eyes, confusion, and abnormal bleeding, please check with your doctor to rule out the possibility of fatty liver disease.


Mushroom is a standard name for white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source,

It is a genus A. Muscaria and belongs to the family Amanitaceae and has been cultivated in many cultures all over the world for food and health benefits.

The chemical constituents of white button mushrooms include
Astraodorol, Psilocybin, Lectin, adustin, ribonuclease, nicotine, 2-hydroxy-4-methoxy-6-methylbenzoic acid, orsellinic acid, melleolide, ergosterol, genistein, daidzein, daucosterol, genistin, uracil, and D-mannitol.

In the concerns of low estrogen production in the risk of nonalcoholic fatty liver disease in menopause women, researchers at the cellular team at the Beckman Research Institute of the City of Hope launched an investigation to examine the effects of white mushrooms in the groups of ovariectomized mice (a model of postmenopausal women).

Selected OVX mice were fed a high-fat diet supplemented with WBM powder before injection of white button mushroom to induce fatty disease patterns.

Application of white button mushroom (WBM) exerted a significant protective effect against liver steatosis in ovariectomized (OVX) mice.

Dietary WBM intake significantly lowered liver weight and hepatic injury markers in OVX mice.

The pathological examination also suggested that WBM lowers fat accumulation in tissue in the livers of mice.

Furthermore, the glucose clearance ability of tested mice also improved substantially compared to the untreated mice group.


According to the microarray analysis, genes associated to the fatty acid biosynthesis pathway, particularly the genes for fatty acid synthetase (Fas), a major determinant of the maximal hepatic capacity to generate fatty acids by de novo lipogenesis and fatty acid elongase 6 (Elovl6) which plays a key role in fat synthesis were down-regulated (reduced function).

Additionally, in vivo, the down-regulation of the expression of FAS and ELOVL6 in the HepG2 cell line by WBM extract was attributed to the inhibition of Liver X receptor (LXR) signaling and it's downstream transcriptional factor SREBP1c.

Where Liver X receptors (LXRs) are important regulators of cholesterol and fatty acid and SREBP-1c is associated with fatty liver and increased visceral fat mass.

The finding indicated that WBM is protective against hepatic steatosis and NAFLD in OVX mice as a model for postmenopausal women.

The study was published on October 25 by the US National Library of Medicine and National Institutes of Health. You can view the publication by clicking the link in the resources,

Taken together, white button mushrooms may be considered a functional food for the prevention and treatment of nonalcoholic fatty liver disease.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(a) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL1, Yan LH, Zhang QW, Wang ZM.(PubMed)
(1) Protective effects of white button mushroom (Agaricus bisporus) against hepatic steatosis in ovariectomized mice as a model of postmenopausal women by Kanaya N1, Kubo M, Liu Z, Chu P, Wang C, Yuan YC, Chen S.(PubMed)
(2) Role of diet and lifestyle changes in nonalcoholic fatty liver disease by William Nseir, Elias Hellou, and Nimer Assy. (PubMed)

#Ginger #Extract Inhibits Parameters Associated with #MetabolicDysfunction, Scientists Suggest

Kyle J. Norton

Scientists may have found a pungent spice which processes a potential to reverse metabolic dysfunction, according to studies.

Metabolic dysfunction is a medical condition characterized by the improper function of the liver or pancreas.

In some cases, metabolic dysfunction may also be caused by enzyme deficiency due to a defective gene, including Antitrypsin (AAT) deficiency, a common metabolic liver disease that affects infants, children, and adults.

The liver, the large organ in humans plays a critical role in breaking down old or damaged blood cells. and a central role in all metabolic processes, including fat metabolism by breaking down fat to energy for the body's needs.

On the other hand, the pancreas also converts the food we eat into energy for the body's cells by regulating blood glucose through the production of insulin.

Dysfunction of one of the 2 organs not only has a strong impact on the energy levels in the body but also increases the risk of diabetes and nonalcoholic liver disease.


According to the statistics provided by the Center for Diseases Control and Prevention, in the US, among adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 1988–1994 to 2007–2012, increasing from 25.3% to 34.2%. The rise of metabolic dysfunction is probably associated with the widespread obesity in the general population, some researchers suggested.


The risk factors associated with the onset of metabolic dysfunction include workers exposed to natural asbestos and to mixed asbestos stock dust, improper nutrition, excessive intake of food with a high content of free sugar, saturated fatty acids and common salt with lack of chicken meat, cereals, fish, vegetables, fruits, and cultured milk foods in the diet and excessive body weight.

Most people with metabolic dysfunction do not experience any symptoms. However, if you have a large waist circumference and experience symptoms of high blood glucose, increased thirst and urination, fatigue, and blurred vision, you may have a metabolic disorder. Please check with your doctor to rule out the possibility.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers in finding a natural compound for the modulation of metabolism evaluated the effects and the mechanisms of ginger extract intake in the metabolic disturbances animal model. Mice selected for the study were induced metabolic dysfunction by a high-refined carbohydrate (HC) diet.

Ginger extract at doses of 200, 600, and 1800 mg/kg supplemented in the daily food of obese Balb/c mice for an 8-week showed a metabolic protective effect by preventing the increase of adiposity induced by HC diet, improving lipid profile, and promoting the decrease of inflammatory markers.


Furthermore, treated mice also exerted a decrease in the recruitment of cells visualized in vivo in the microvasculature of adipose tissue, a decrease in inflammatory cytokines, and an increase in adiponectin serum levels.


The finding suggested that ginger processes anti-metabolic dysfunction in obese mice induced by a long-term high-refined carbohydrate (HC) diet.

In order to reveal more information about ginger anti-metabolic syndrome activity, used in traditional medicine, researchers examined the herbal effects on hyperlipidemia, hyperglycemia, oxidative stress, and inflammation.

Ginger showed a potency activity in reducing the onset of metabolic syndrome through
mediating the several transcription factors associated with the metabolic function, including activated glucose and fatty acid uptake.


The results indicated the beneficial effects of ginger on obesity and related complications in MetS.


Taken together, ginger may be considered a functional remedy for the prevention and treatment of metabolic dysfunction, pending the confirmation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Ginger (Zingiber officinale Rosc.) Ameliorated Metabolic and Inflammatory Dysfunction Induced by High-Refined Carbohydrate-Containing Diet in Mice by Oliveira CT1, Lacerda DR1, Zicker MC1, Martins LB1, Teixeira MM2, Bello de Araujo RL1, Ferreira AVM. (PubMed)
(2) Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review by Wang J1,2, Ke W1, Bao R1, Hu X1,2, Chen F. (PubMed)
(3) [Risk factors and development of metabolic disorders in workers of "Uralasbest" enterprise][Article in Russian] by Prianichnikova NI, Mazhaeva TV, Dubenko SÉ, Obukhova TIu, Chirkova IA.(PubMed)
(4) Metabolic Syndrome Prevalence by Race/Ethnicity and Sex in the United States, National Health and Nutrition Examination Survey, 1988–2012 by ORIGINAL RESEARCH — Volume 14 — March 16, 2017. (CDC)

#Healthyfood #Beets and #Carrots Inhibit Parameters Associated with the Production of Pro-Inflammatory Cytokines and Fatty Liver Tissues, According to Studiesnm

Kyle J. Norton

A fatty liver is a liver condition associated with the accumulation of excess fat in the liver.
Non-alcoholic fatty liver (NAFL) is the early stage of nonalcoholic steatohepatitis (NASH) caused by the accumulation of fat in the liver, other than excessive use of alcohol.

Nonalcoholic steatohepatitis (NASH) is a type of inflammatory non-alcoholic fatty liver disease caused by excessive fat accumulated in the liver.

Nonalcoholic steatohepatitis (NASH) is asymptomatic until the condition is developed into cirrhosis, the condition that causes advanced liver scars, and reduces the performance of the liver.

In other words, if more than 5% – 10% percent of your liver’s weight is fat, you have a fatty liver (steatosis).

According to the statistics, non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of liver disease affecting 100 million people in the US. Out of that number, approximately 20% of people have NASH.

Medical conditions such as obesity, metabolic syndrome, and type 2 diabetes are some of the metabolic risk factors that have been found to induce the development of NASH.

As of today, there is no effective treatment for NASH. Depending on the condition people with overweight or obese are recommended to lose weight. The aim of medical treatment is to reduce the symptoms delay the progression of the condition and improve the quality of life.

Out of many prevalent factors that cause the onset of NASH, some researchers suggested that the promotion of a high-fat diet over the past few decades induced a high percentage of the overweight and obese population may be the major culprit associated with the rise of NASH.

Dr. Jensen VS, the lead scientist wrote, "Hepatic dysfunction and inflammation were confirmed in HFD-fed rats by elevated levels of hepatic MCP-1 (p < 0.0001), TNF-alpha (p < 0.001) and plasma β-hydroxybutyrate (p < 0.0001), and in NASH-fed rats by elevated levels of hepatic MCP-1 (p < 0.01), increased hepatic macrophage infiltration (p < 0.001), and higher plasma levels of alanine aminotransferase (p < 0.0001) aspartate aminotransferase (p < 0.05), haptoglobin (p < 0.001) and TIMP-1 (p < 0.01) compared to Control".

And, " dietary fat and cholesterol are the primary drivers of NAFLD development and progression in rats, while fructose mostly exerts its effect on the circulating lipid pool".

Betaxanthins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, Sicilian prickly pear, etc.

In finding a potent ingredient for the treatment of liver disease, researchers examined the protecting effects of bioactive agents of the lyophilized table beet and carrot powder on fatty liver.

The shorten term study included male Wistar rats fed with chow with or without high fat (2% cholesterol, 0.5% cholic acid, 20% sunflower oil) and treated with 0.1 or 1 g/bwkg/day natural product for ten days parallel with the feedings.


Based on the tested analysis, compared to other feedings, the higher dose of the natural product better decreased the induced free radical reactions, cyclooxygenase-2, and proteins associated with the production of pro-inflammatory cytokines in normal and fatty liver tissues.

More precisely, the natural treatment of beet and carrot powder inhibited liver oxidative stress by inhibiting the inflammatory expression without causing significant changes in all global antioxidant parameters.


However, the antioxidant activity of mobilized methyl group concentrations associated with liver stress also increased by fatty liver tissues.

Based on the evidence, researchers said, "Beet and carrot proved to be a "functional food" in rats with alimentary fat-induced fatty liver. It cannot be ruled out that this beneficial effect may have clinical relevance".

Taken together, beet and carrot may be considered functional remedies for the prevention of fatty liver disease, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Experimental food-induced fatty liver and its adjuvant therapy with natural bioactive substances].
[Article in Hungarian] by Hegedüs V1, Gerö D, Mihály Z, Szijártó A, Zelles T, Sárdi E. (PubMed)

#ChineseCabbage Reduces the Incidence of Liver Cancer Induced by Aflatoxin B1, Researchers Find

Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing it to other parts of the body.

The liver also produces cholesterol, a waxy substance that aids digestion, builds cell membranes, and produces vitamin D and steroid hormones.

Liver disease is a class of medical conditions characterized by the reduction of partly or completely the function of the liver, including liver failure.

Liver cancer is a medical condition characterized by cell growth irregularly in the liver tissue.

Liver cancer at an early stage does not cause any symptoms. However, at the advanced stage, liver cancer cells can cause a wide range of symptoms including jaundice, abdominal swelling and pain, and dark urine and white stool accompanied by the general symptoms of cancers such as unintended weight loss, loss of appetite, chronic fatigue and tiredness and gastrointestinal discomforts.

The causes of liver cancer are associated with the alternation of cell DNA which normally begins in the cells on the surface of the inner lining.

The most common risk factor of liver cancer is infected by the hepatitis virus. However, in North America, due to the overexpression of the overweight and obese population, liver cancer may slowly progress from nonalcoholic fatty liver disease through cirrhosis to liver cancer.


According to the statistics provided by the Canadian Cancer Society, every year, approximately, 1,900 men and 580 women are diagnosed with liver cancer, causing the death of 950 men and 270 women.

In 2017, 2,500 Canadians were diagnosed with liver cancer and 1,200 Canadians died from liver cancer.

Compared to the early stage of other cancers, the 5 years survival rate in the early stage diagnosis is only 31%, and 43% of people with liver cancer are diagnosed at stages 0 and 1.

In finding a potential plant that processes anti-invasive tumor activity researchers compared the potential anticancer ability of Chinese cabbage powder, which is a complex water-soluble extract from Chinese cabbage by spray-drying at an outlet temperature of 130 °C on liver cancer.
According to the chemical analysis, Chinese cabbage powder processed at least 11 potential anticancer substances.

In a 90-day animal experiment, 10% of Chinese cabbage powder in drinking water could improve the plasma micronutrient status, and inhibit the formation of aflatoxin B1-DNA adducts in liver cells in the initiation of tumor growth.

Furthermore, in vivo, 10% of Chinese cabbage powder effectively reduced the incidence of liver tumors induced by aflatoxin B1 from 6.67% to 0%.

The dose analysis assays suggested that 10% may be the minimal effective dose to prevent the occurrence of early liver tumors.

Collectively, researchers wrote, "This study will help elucidate the basis of epidemiological observations of dietary cancer prevention in humans, as well as explore related mechanisms".

Taken together, Chinese cabbage may be considered a functional food for the prevention and treatment of liver cancer, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibition effects of Chinese cabbage powder on aflatoxin B1-induced liver cancer by Wang T1, Li C2, Liu Y2, Li T3, Zhang J4, Sun Y. (PubMed)

#Phytochemical Sulforaphane (Dithiolthiones) Inhibits Parameters Associated with the Risk of #LiverDisease, According to Studies

Kyle J. Norton

Scientists may have found a natural ingredient for the prevention and treatment of liver disease with no side effects, according to studies.

Liver disease in most cases is linked to alcohol or drugs. In fact, it can be caused by a variety of factors and affects everyone from infants to older adults, including infected viruses such as hepatitis A, B, C, and medication overload.

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

The most common symptoms of liver disease include weakness and fatigue, weight loss, nausea, vomiting, and jaundice.

If you are experiencing some of the above symptoms, please make sure you check with your doctor to rule out the possibility of liver disease.

According to the statistic provided by the Canadian Liver Foundation, approximately, one in 10 Canadians, or more than three million people, have some form of liver disease and over a period of only eight years, the death rate from liver disease has risen nearly 30%.

These incidences of liver disease not only lead to dismissing the quality of life and life expectancy but also cause a financial burden on the health care system.

Conventional treatment of liver disease depends on your diagnosis. Most cases of liver disease can be treated with lifestyle modifications, such as stopping alcohol use in alcoholic fatty liver disease or losing weight, in nonalcoholic liver disease.

Dr. Valerio Nobili, the lead scientist in the examined the role of lifestyle changes in the management of chronic liver disease, said, "several liver conditions which are directly affected by overweight and obese status, including non-alcoholic fatty liver disease, chronic infection with hepatitis C virus and post-liver transplant status".

And, "The deleterious effects of obesity on liver disease and overall health can be significantly impacted by a culture that fosters sustained nutritional improvement and regular physical activity".

With an aim to find a natural ingredient for the treatment of liver disease, researchers evaluated the ability of sulforaphane, an activator of Nrf2, to blunt CYP2E1-dependent, ethanol-induced steatosis in vivo and in vitro.


Where Nuclear factor (erythroid-derived 2)-like 2, (Nrf2), is a pro- antioxidant protein that plays a critical role in protecting our body against oxidative damage triggered by injury and inflammation.

CYP2E1 is a protein involved in the metabolism of xenobiotics in the body.

The application of sulforaphane (SFN) treatment increased the levels of antioxidants by activating the levels of the Nrf2 and lowering oxidant stress observed by the decline in lipid peroxidation and increase in glutathione (GSH) levels.

SFN also decreased liver levels of triglycerides and cholesterol elevated by the injection of ethanol.

The results strongly suggested that SFN inhibited liver disease by increasing the expression of antioxidant enzymes and lowering the expression of free radicals as well as reducing the liver fat deposits.

Moreover, in the investigation to determine whether glucoraphanin and its breakdown product sulforaphane, are potent modulators of various phase I and phase II enzymes involved in carcinogen-metabolizing enzyme systems in vitro, researchers showed that injection of glucoraphanin at higher concentrations (25 μM) decreased dealkylation of methoxyresorufin, a marker for cytochrome P4501 activity

Where cytochrome P4501 is an enzyme involved in the metabolism of endogenous substrates and drugs, as well as the activation of certain toxins and environmental pollutants.

Compared to glucoraphanin, sulforaphane is superior to its precursor in modulating carcinogen-metabolizing enzyme systems in vitro.


The University of Rhode Island, Kingston study also suggested that SF activates Nrf2 activation in inhibited lipid accumulation in white adipose tissue, suppressed adipogenesis, insulin resistance, and glucose intolerance, and hepatic steatosis in Lep(ob/ob) mice.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
rights
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis by Zhou R1, Lin J, Wu D.(PubMed)
(2) Sulforaphane is superior to glucoraphanin in modulating carcinogen-metabolizing enzymes in Hep G2 cells by Abdull Razis AF1, Noor NM. (PubMed)
(3) Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice by Xu J1, Kulkarni SR, Donepudi AC, More VR, Slitt AL. (PubMed)
(4) The role of lifestyle changes in the management of chronic liver disease by Valerio Nobili, Christine Carter-Kent,2 and Ariel E Feldstein. (PMC)

#Cranberry Ameliorates HFD-Induced Metabolic Disturbances, and Prevents the Early onset of Nonalcoholic Fatty Liver Disease (NAFLD)

Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Liver disease is a class of medical conditions characterized by the reduction partly or completely the function of the liver, including liver failure.

Nonalcoholic fatty liver disease (NAFLD) is a chronic condition caused by fat accumulated in the liver over time, in the absence of excessive alcohol use. The disease can be classified into the types of non-inflammatory fatty liver (NAFl) and inflammatory nonalcoholic steatohepatitis (NASH)(1).

Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of cirrhosis and liver cancer.

According to world statistics, nonalcoholic fatty liver disease (NAFLD) is normally known as a disease of the Western world(2). However, due to the economic prosperity of Southeast Asia (3), the disease also was found in a large population in the cities, causing concerns of many scientists in the region(4)(6).

According to the joint assessment of the prevalence of non-alcoholic fatty liver disease and risk factors for advanced fibrosis and mortality in the US, led by the Stanford University School of Medicine, "The prevalence of NAFLD in the United States (U.S.) has risen from 18% in 1988–1991 to 31% in 2011–2012. Estimates of NAFLD prevalence for adults in Western countries are 20–30%, with much higher prevalence in adults with obesity (80–90%), diabetes (30–50%), and hyperlipidemia (90%)"(5).

The exact causes of NAFLD aren't well understood. Some researchers suggested that certain risk factors such as long-term use of certain medications(8), genetic preposition(8), insulin resistance(8), high cholesterol(8) and triglycerides(8) in the blood, polycystic ovary syndrome(8), metabolic syndrome(8), obesity(8), and type 2 diabetes(8) are associated with the onset of the disease.


Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the prevention and treatment of liver diseases, researchers investigated cranberry effects on metabolic profiles, including that during the progression of non-alcoholic fatty liver disease (NAFLD), in a high-fat diet (HFD)-fed C57BL/6 mice.

According to the results of the experiment, the application of cranberry reduced the levels of oxidative stress in mice that were fed HFD diets with supplementation of 1 and 5% cranberry powder, compared to HFD-fed control mice.

1 week after beginning the diets to the end of the study, the body weight of mice in the cranberry-treatment groups was significantly lower, compared to mice in the HFD-fed control group.

Furthermore, during the early treatment phase, the injection of cranberry suppressed the elevation of serum triglycerides, leading to the smaller of adipocytes in the adipose tissues in HFD-fed mice compared to the cells in HFD-fed control mice.


More importantly, the nonalcoholic fatty liver disease (NAFLD) characteristics of the levels of lipid-droplet formation and hepatocyte ballooning in the liver were drastically decreased in cranberry-supplemented-HFD-fed mice relative to the levels in HFD-fed control mice.

Based on the findings, researchers said, " Cranberry ameliorates HFD-induced metabolic disturbances, particularly during the early treatment stage, and exhibits considerable potential for preventing the progression of NAFLD.".


Taken together, cranberry may be considered a functional food for the treatment of NAFLD, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cranberry Attenuates Progression of Non-alcoholic Fatty Liver Disease Induced by High-Fat Diet in Mice by Shimizu K1, Ono M2, Imoto A1, Nagayama H1, Tetsumura N1, Terada T1, Tomita K2, Nishinaka T. (PubMed)
(2) Non-alcoholic Fatty Liver Disease (NAFLD)Treatment in Phytochemicals Perspective by Kyle J. Norton

#Herbal #Bilberry Inhibits Biomarkers Associated with Nonalcoholic Fatty Liver Disease (NAFLD), According to Studies

Kyle J. Norton

Nonalcoholic fatty liver disease (NAFLD) is a type of noninflammatory fatty liver disease caused by fat accumulated in the liver other than excessive alcohol consumption.

People who have an accumulation of triglycerides within hepatocytes that exceeds 5% of liver weight are considered to have nonalcoholic fatty liver disease.

According to the statistics, nonalcoholic fatty liver disease (NAFLD) has risen rapidly over the past few decades and become the most common cause of chronic liver disease in the developing world. The disease affects between 17-30% of the population in Western countries and 2-4% worldwide.

Epidemiologically. obesity, type II diabetes, dyslipidemia, and insulin resistance are the well-known primary causes of NAFLD.

The findings strongly suggested that NAFLD is a geographically related disease associated with dietary patterns.


Dr. Alanna McCarthy, the lead scientist in the examination of diet patterns in the risk NAFLD wrote, "Non-alcoholic fatty liver disease (NAFLD) is a serious consequence of high-fat diet intake and currently affects approximately one-third of the world’s entire population".

And, "Recent evidence suggests that patients with NAFLD have a higher incidence of cardiovascular disease compared to the general population. However, little is known about the link between NAFLD and pathological cardiac remodeling leading to heart disease".

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.

With an aim to find natural prevention and treatment of non-alcoholic fatty liver disease (NAFLD), researchers investigated the effects of anthocyanin supplementation on insulin resistance and liver injury biomarkers in patients.

74 subjects with NAFLD included in the study were divided into 2 groups in this double-blind, randomized study. Patients received either purified anthocyanin (320 mg/d) derived from bilberry and black currant or placebo for 12 weeks.

During the experiment, the anthocyanin group exhibited a significant decrease in plasma alanine aminotransferase, cytokeratin-18 M30 fragment, and myeloperoxidase, the biomarkers associated with NAFLD, compared to controls.

Compared to the baseline, the anthocyanin group significantly decreased in fasting blood glucose and homeostasis model assessment for insulin resistance, however, these differences were not significant relative to placebo controls.

Not surprisingly, anthocyanin supplementation significantly decreased the 2-hour loading glucose level compared to control, according to the oral glucose tolerance test.


Based on the findings, researchers said, "A 12-week supplement of purified anthocyanin improved insulin resistance, indicators of liver injury, and clinical evolution in NAFLD patients".

Furthermore, according to the results from the study of ApoE(∗)3Leiden mice fed a Western-type cholesterol-containing diet without (HC) or with 0.1% (w/w) Mirtoselect (HCM), an anthocyanin-rich bilberry extract for 20weeks on diet-induced NASH, Mirtoselect treatment group showed an attenuated HC-induced hepatic steatosis and reduced hepatic cholesteryl ester content.

Furthermore, injection of Mirtoselect also exerted local anti-inflammatory effects in the liver by reducing inflammatory cell clusters and neutrophil infiltration in HCM.

In other words, HCM protected the liver against the HC diet and significantly induced hepatic expression of pro-inflammatory and pro-fibrotic genes associated with the onset of NAFLD.

Dr. Morrison MC, the lead scientist, after taking other factors into account wrote, "Mirtoselect attenuates the development of NASH, reducing hepatic lipid accumulation, inflammation, and fibrosis, possibly mediated by local anti-inflammatory effects associated with reduced accumulation and crystallization of intrahepatic free cholesterol".

Taken altogether, bilberry-processed abundantly bioactive compound anthocyanin may be considered a functioning remedy for the treatment of nonalcoholic fatty liver disease, pending the validation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) A CONSORT-compliant, randomized, double-blind, placebo-controlled pilot trial of purified anthocyanin in patients with nonalcoholic fatty liver disease by Zhang PW1, Chen FX, Li D, Ling WH, Guo HH. (PubMed)
(2) Mirtoselect, an anthocyanin-rich bilberry extract, attenuates non-alcoholic steatohepatitis and associated fibrosis in ApoE(∗)3Leiden mice by Morrison MC1, Liang W2, Mulder P2, Verschuren L2, Pieterman E2, Toet K2, Heeringa P3, Wielinga PY2, Kooistra T2, Kleemann R. (PubMed)
(3) High-Fat-Diet Induced Non-Alcoholic Fatty Liver Disease and Cardiac Physiology in Mice by
Alanna McCarthy and Stephen Luckey. (Faseb Journal)

#GreenTea EGCG Promotes #WeightLoss and Attenuates Symptoms of Nonalcoholic Fatty Liver Disease, Researchers Suggest

Kyle J. Norton

Green tea may be considered as a functional food in lower risk and treatment for patients with nonalcoholic fatty liver disease, a respectable institute opinionated.
Non-alcoholic Fatty Liver Disease is a condition caused by over accumulated of fat in the liver.

Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including weakened immunity and painful cases of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will solve the aversion.

According to the University of Connecticut, Storrs, the efficacy of green tea for the treatment of obese patients with nonalcoholic fatty liver disease is associated with polyphenolic catechins in the induction of hypolipidemic, thermogenic, antioxidant, and anti-inflammatory activities.

These chemical compounds have also been found to mitigate the occurrence and progression of NAFLD.


Dr. Masterjohn C, the lead author said, "(The phytochemical compounds) demonstrating the hepatoprotective properties of green tea and its catechins and the proposed mechanisms by which these targeted dietary agents protect against NAFLD"

Furthermore, in mice fed on a high-fat diet for 24 weeks., then injected with EGCG (10, 20 and 40 mg·kg(-1)·d(-1), ip), for 4 weeks, researchers found that treated mice showed a significant improvement of a high-fat diet in induced the body weight, grade 2 or 3 liver fatty degeneration (steatosis, lobular inflammation, and ballooning), severe hyperlipidemia, hyperglycemia, hyperinsulinemia, and insulin resistance.

The phytochemical EGCG, in dose-dependent, also enhanced insulin clearance and upregulated IDE protein expression and enzyme activity in regulated levels of glucose in the liver of treated mice.


In fact, EGCG not only promoted weight loss but also attenuated symptoms of mice with nonalcoholic fatty liver disease.

Promisingly, in the study of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats, researchers also indicated that GTP intervention not only decreased weight gain and significantly lowered visceral fat but also reduced fasting serum insulin, glucose and lipids levels, through ameliorated expression of hepatic TG accumulation and cytoplasmic lipid droplet as well as diminished hepatic lipogenesis and triglycerides outflux from liver.


Taken together, green tea has expressed a significant enhancement in reduced risk and treatment of
nonalcoholic fatty liver disease, through many aspects. However large amounts of intake regularly should be taken with care to prevent toxicity.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Sources
(1) Therapeutic potential of green tea in nonalcoholic fatty liver disease by Masterjohn C1, Bruno RS.(PubMed)
(2) Green tea polyphenol epigallocatechin-3-gallate ameliorates insulin resistance in non-alcoholic fatty liver disease mice by Gan L1, Meng ZJ1, Xiong RB2, Guo JQ1, Lu XC1, Zheng ZW1, Deng YP1, Luo BD1, Zou F3, Li H1.(PubMed)
(3) Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats by Tan Y1, Kim J1, Cheng J1, Ong M1, Lao WG1, Jin XL1, Lin YG1, Xiao L1, Zhu XQ1, Qu XQ1.(PubMed)

#Phytochemical #Triterpenoid-Rich Fraction (TF) From Ilex Hainanensis Merr. Inhibits Nonalcoholic Fatty Liver Disease through Its Antioxidant Activity, Researchers Say

Kyle J. Norton

Scientists may have found a bioactive ingredient for the prevention and treatment of nonalcoholic fatty liver disease with no side effects, according to studies.

Nonalcoholic Fatty liver disease (NAFLD) is a condition of fatty liver disease as a result of accumulated fat in the liver over time, not caused by abusive alcohol consumption.

Most patients in the early stage of nonalcoholic fatty liver disease do not experience any symptoms until the disease has advanced to the critical stage.

According to the statistics, NAFLD is the most common cause of liver disease in the Western world.

Most diseases associated with NAFLD are obesity, high blood pressure, diabetes, and high cholesterol.

People with insulin resistance, diabetes, high blood pressure, high blood fat levels, and/or metabolic syndrome, are associated with an increased risk of NAFLD.

Other risk factors for the incidence of NAFLD are the increase in age, ethnicity, and family history.


Believe or not, people who carry certain mutated genes are also at a higher risk of the disease. Dr. Silvia Sookoian in the concern of the global epidemic risk of Nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease wrote, "Although the disease is relatively benign in the early stages, when severe clinical forms, including nonalcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma, occur, they result in worsening the long-term prognosis.".


And, " A growing body of evidence indicates that NAFLD develops from a complex process in which many factors, including genetic susceptibility and environmental insults, are involved".

Triterpenoid is various unsaturated hydrocarbons, found in essential oils and oleoresins of plants, including Ilex hainanensis Merr.

In finding a natural ingredient or whole food for the prevention and treatment of non-alcoholic fatty liver disease with no side effects, researchers at the China Pharmaceutical University evaluated the effect of the triterpenoid-rich fraction (TF) from Ilex hainanensis Merr. on NAFLD in an animal model.

The study included male Sprague-Dawley (SD) rats fed a normal diet (control) or high-fat diet (NAFLD model) 4 four weeks, followed by the orally administrated TF (250 mg/kg) for another two weeks.

Before the application of the TF compound, rats fed a high-fat diet displayed abnormally high blood cholesterol levels and a decline in liver function compared to control.

The application of TF on these rats not only restores the health issues caused by a high-fat diet but also decreases the expression of plasma levels of triglyceride, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol.

Levels of alanine transaminase (p < 0.05), aspartate aminotransferase (p < 0.01), liver index (p < 0.05), the indication of liver oxidative stress and insulin resistance index (p < 0.05) were also decreased by TF administration.

Furthermore, TF improved the liver lesions induced by the high-fat diet.


Moreover, TF injection also alleviated oxidative stress and inflammation status indicated by the declined levels of oxidative markers, free radicals, and pro-inflammatory cytokines.


Dr. Cui WX, the lead scientist, after taking into account co and confounders said, "TF has the potential ability to protect the liver against NAFLD by regulating lipids metabolism and alleviating insulin resistance, inflammation, and oxidative stress".

Additionally, the study reconfirms the traditional use of herbal Ilex hainanensis Merr. for the treatment of non-alcoholic fatty liver disease, researchers examine the compound Chlorogenic acid, kaempferol-7-O-β-d-glucoside, and ilexgenin, a novel triterpenoid, the three major bioactive components in I. hainanensis extract.

Compared to normal rats, the application of I. hainanensis extract exerted a significant change in NAFLD rats.

The efficacy of the herbal extract was attributed to the anti-NAFLD activity of chlorogenic acid, kaempferol-7-O-β-d-glucoside, and ilexgenin A.


Taken together, phytochemical Triterpenoid may be considered a supplement for the prevention and treatment of non-alcoholic fatty disease pending the large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Reference
(1) Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography/electrospray ionization mass spectrometry by Jie Yanga,1, Fang Lva, 1, Xiao-qing Chenb, Wei-xi Cuia, Li-hong Chenc, Xiao-dong Wena, Qiang Wanga(Science direct)
(2) Triterpenoid-rich fraction from Ilex hainanensis Merr. attenuates non-alcoholic fatty liver disease induced by high-fat diet in rats by Cui WX, Yang J, Chen XQ, Mao Q, Wei XL, Wen XD, Wang Q.(PubMed)
(3) Genetic predisposition in nonalcoholic fatty liver disease by bSilvia Sookoian1 and Carlos J. Pirola2(PMC)

#Healthyfood #Tomato Inhibits Liver Stress Markers Against the Onset of #HepaticSteatosis, Researchers Show

Kyle J. Norton

Hepatic steatosis is a medical condition caused by the accumulation of fat in the liver.
In other words, if the intrahepatic fat of your liver is more than 5% of your liver weight, you are considered to have hepatic steatosis. Over time, untreated hepatic steatosis can lead to liver metabolic dysfunction, inflammation, and advanced forms of nonalcoholic fatty liver disease.


Epidemiologically, hepatic steatosis has been found to induce complications in patients with obesity, alcohol intoxication, and/or hepatic disorders.

There are several mechanisms involved in the accumulation of intrahepatic fat, including increased flux of fatty acids to the liver, increased de novo lipogenesis, and/or reduced clearance through β-oxidation or very-low-density lipoprotein secretion.

People who are obese, having the condition of insulin resistance or diabetes, dyslipidemia, hypertension, metabolic syndrome, rapid weight loss, and use hepatotoxic medications total parenteral nutrition (TPN) are at an increased risk of hepatic steatosis.


Out of many prevalent factors involved in the onset of hepatic steatosis, some researchers suggested that the promotion of the Western diet over the past few decades in the Western world may have a strong and negative impact that accelerates the incidence onset.


Dr. Michael D. Roberts, the lead scientist wrote, "Six weeks of WD feeding caused hepatic steatosis development as evidenced by the 2.25-fold increase in liver triacylglycerol content, but did not induce advanced liver disease (i.e., no overt inflammation or fibrosis)".


And, "sub-chronic WD feeding appears to increase hepatic steatosis development over a 6-week period but only induces select inflammation-related liver transcripts, mostly acute phase response genes. These findings continue to outline the early stages of NAFLD development prior to overt liver inflammation and advanced liver disease".

The results strongly suggested the risk of the Western diet on hepatic steatosis developing.

Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to discover healthy foods for the treatment of hepatic steatosis, researchers examined the effect of tomato consumption on biomarkers and gene expression related to lipid metabolism in rats with induced steatosis.

The study included 24 adult male Sprague-Dawley rats (8 weeks old) randomly assigned to (n = 6 rats/group) four experimental groups, including NA (normal diet and water), NL (normal diet and tomato juice), HA (high-fat diet and water) and HL (high-fat diet and tomato juice).

According to the tested assays, before treatment of tomato, the HA group fed a high-fat diet-induced hepatic steatosis confirmed by the levels of alanine aminotransferase and aspartate aminotransferase, an indication of liver stress and injury.


Tomato treated group showed a significant increase in levels of lycopene and its secondary metabolites in the livers of these animals, particularly in HL than in the NL group, apparently due to higher absorption (63.07 vs. 44.45%).

Furthermore, tomato treated group protected the liver by alleviating oxidative stress through the reduction of isoprostanes in the urine observed by increased levels of antioxidant enzymes.

Moreover, levels of high-density lipoprotein were also increased in the HL group compared to the HA group.

Interestingly, overexpression of several genes related to lipid metabolism was also found in the HL group compared to nontreatment groups.

In other words, tomatoes inhibited the onset and progression of hepatic steatosis in high-fat diet mice by inhibiting liver oxidative stress and enhancing lipid metabolism.


Dr. Martín-Pozuelo G, the lead scientist wrote, "The consumption of tomato juice and tomato products reduced hallmarks of steatosis, plasmatic triglycerides, and very-low-density lipoproteins, and increased lipid metabolism by inducing an overexpression of genes involved in more efficient fatty acid oxidation".

Taken altogether, tomato may be considered a dietary supplement for the prevention and treatment of hepatic steatosis, pending to large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The effect of tomato juice supplementation on biomarkers and gene expression related to lipid metabolism in rats with induced hepatic steatosis by Martín-Pozuelo G1, Navarro-González I, González-Barrio R, Santaella M, García-Alonso J, Hidalgo N, Gómez-Gallego C, Ros G, Periago MJ. (PubMed)
(2) Lipid biomarkers and metabolic effects of lycopene from tomato juice on the liver of rats with induced hepatic steatosis by Bernal C1, Martín-Pozuelo G, Lozano AB, Sevilla A, García-Alonso J, Canovas M, Periago MJ. (PubMed)
(3) Western diet-induced hepatic steatosis and alterations in the liver transcriptome in adult Brown-Norway rats by Michael D. Roberts, C. Brooks Mobley, Ryan G. Toedebush, Alexander J. Heese, Conan Zhu,Anna E. Krieger, Clayton L. Cruthirds, Christopher M. Lockwood, John C. Hofheins, Charles E. Wiedmeyer, Heather J. Leidy, Frank W. Booth, and R. Scott Rector. (PMC)

#Lyophilized Table #Beet and #Carrot Powder Inhibits Proteins Associated with a Decreased Risk of #FattyLiverDiseases, Researchers Show

Kyle J. Norton

A fatty liver is a liver condition associated with the accumulation of excess fat in the liver.

Non-alcoholic fatty liver (NAFL) is the early stage of nonalcoholic steatohepatitis (NASH) caused by the accumulation of fat in the liver, other than excessive use of alcohol.

Nonalcoholic steatohepatitis (NASH) is a type of inflammatory non-alcoholic fatty liver disease caused by excessive fat accumulated in the liver.

Nonalcoholic steatohepatitis (NASH) is asymptomatic until the condition develops into cirrhosis, the condition that causes advanced liver scars and reduces the performance of the liver.

In other words, if more than 5% – 10% percent of your liver’s weight is fat, you have a fatty liver (steatosis).

According to the statistics, non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of liver disease affecting 100 million people in the US. Out of that number, approximately 20% of people have NASH.

Medical conditions such as obesity, metabolic syndrome, and type 2 diabetes are some of the metabolic risk factors that have been found to induce the development of NASH.

As of today, there is no effective treatment for NASH. Depending on the condition people with overweight or obese are recommended to lose weight. The aim of medical treatment is to reduce the symptoms and delay the progression of the condition and improve the quality of life.

Out of many prevalent factors that cause the onset of NASH, some researchers suggested that the promotion of a high-fat diet over the past few decades induced a high percentage of the overweight and obese population may be the major culprit associated with the rise of NASH.

Dr. Jensen VS, the lead scientist wrote, "Hepatic dysfunction and inflammation were confirmed in HFD-fed rats by elevated levels of hepatic MCP-1 (p < 0.0001), TNF-alpha (p < 0.001) and plasma β-hydroxybutyrate (p < 0.0001), and in NASH-fed rats by elevated levels of hepatic MCP-1 (p < 0.01), increased hepatic macrophage infiltration (p < 0.001), and higher plasma levels of alanine aminotransferase (p < 0.0001) aspartate aminotransferase (p < 0.05), haptoglobin (p < 0.001) and TIMP-1 (p < 0.01) compared to Control".

And, " dietary fat and cholesterol are the primary drivers of NAFLD development and progression in rats, while fructose mostly exerts its effect on the circulating lipid pool".

Betaxanthins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, Sicilian prickly pear, etc.

In finding a potent ingredient for the treatment of liver disease, researchers examined the protecting effects of bioactive agents of the lyophilized table beet and carrot powder on fatty liver.

The shortened-term study included male Wistar rats fed with chow with or without high fat (2% cholesterol, 0.5% cholic acid, 20% sunflower oil) and treated with 0.1 or 1 g/bwkg/day natural product for ten days parallel with the feedings.

Based on the tested analysis, compared to other feedings, the higher dose of the natural product better decreased the induced free radical reactions, cyclooxygenase-2, and proteins associated with the production of pro-inflammatory cytokines in normal and fatty liver tissues.

More precisely, the natural treatment of beet and carrot powder inhibited the liver oxidative stress by inhibiting the inflammatory expression without causing significant changes in all global antioxidant parameters.

However, the antioxidant activity of mobilized methyl group concentrations associated with liver stress also increased in fatty liver tissues.

Based on the evidence, researchers said, "Beet and carrot proved to be a "functional food" in rats with alimentary fat-induced fatty liver. It cannot be ruled out that this beneficial effect may have clinical relevance".

Taken together, beet and carrot may be considered functional remedies for the prevention of fatty liver disease, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Experimental food-induced fatty liver and its adjuvant therapy with natural bioactive substances].
[Article in Hungarian] by Hegedüs V1, Gerö D, Mihály Z, Szijártó A, Zelles T, Sárdi E. (PubMed)