Thursday, 7 July 2022

Phytochemical Beta-Sitosterol May Process Anti Prostate Cancer Activity

By Kyle J. Norton

The prostate warped around the urethra is a gland of the male reproductive system found in front of the rectum and just below the bladder and responsible for making some of the semen that carries sperm.

The muscle of the prostate gland also plays a critical in nourishing and protecting sperm by secreting fluid in perm ejaculation into the urethra.

Prostate cancer is a medical and chronic condition caused by cell growth irregular in the prostate gland. Most cases of prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during Physical (rectum) exams.

Most cases of prostate cancer begin in the cells on the surface of the inner lining of the prostate tissue before penetrating into deeper layers to induce colonization.

At the advanced stage, the prostate cancer cells can spread to distant parts of the body, leading to secondary metastasis.

According to the statistics, prostate cancer is the most common cancer among men particularly older over 65, after skin cancer. in 2019, approximately 174,650 men in the US will be diagnosed with prostate cancer.

The average age of diagnosis is 66.

The most common symptoms of the prostate at the later stage are frequent urination and weak or interrupted urine flow due to the tumor that affects the tube surrounded by the prostate.

In some cases, patients may experience symptoms of blood in the urine and pain due to the oversize tumor that has pressed on the nearby blood vessels and nerve cells.

The new onset of erectile dysfunction is also common in patients with prostate cancer.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belonging to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of cancer, researchers examined the effect of Arum Palaestinum extract containing additional isovanillin, linolenic acid, and β-sitosterol (GZ17) on prostate cancer in an animal model.

The study included male NU/NU mice (8 weeks old) with xenograft tumors derived from the prostate cancer cell line treated daily with 1000 mg/kg body weight gavage of the suspension GZ17 with control mice (10 mice in each group) received a vehicle in the same manner and volume.

Arum Palaestinum extract GZ17 showed a decline in the number of live prostates cancer cells in a dose/dependent manner after a 24 h exposure at doses of 0.015 to 6.25 mg/mL.

However, the fortified version of the extract that contained higher levels of isovanillin, linolenic acid, and β-sitosterol had a stronger effect on the cell death rate, compared to GZ17.

At the highest dose, GZ17 increased cell death from 30 % to 55 % compared to the vehicle control that had no effect on cell numbers.

More importantly, GZ17 showed no toxic effects on healthy cells in the doses that were toxic to treated cancer cells.

In NU/NU mice with xenograft prostate tumors, GZ17 treatment had a dramatic inhibition of tumor progression, compared to tumors steadily growing in the control group through the 3 weeks.

Finally, according to the tumor assays, the rate of tumor volume increase was 73 mm(3)/day for the vehicle group compared to only 24 mm(3)/day in GZ17 treated mice. 

Based on the results, researchers said, "Fortified Arum palaestinum Boiss caused a reduction in live cells within prostate cancer spheroids and blocked tumor growth in xenografted prostate tumors in mice without signs of toxicity".

Taken altogether, beta-Sitosterol used a combination with other herbal medicine and phytochemicals may be considered a supplement for the prevention and treatment of prostate cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Arum Palaestinum with isovanillin, linolenic acid and β-sitosterol inhibits prostate cancer spheroids and reduces the growth rate of prostate tumors in mice by Cole C1, Burgoyne T2, Lee A3,4, Stehno-Bittel L5,6, Zaid G. (PubMed)

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