Kyle J. Norton
Glioblastoma is one of the most aggressive cancers that begins within the brain.
According to statistics, most patients diagnosed with cancer die within 12 to 15 months. Less than 5% of patients are survived longer than five years.
If you are male you are at 1.5 higher risk of glioblastoma, compared to your female counterpart.
The causes of glioblastoma are unknown, some researchers suggested that genetic preposition and environmental factors, previous radiotherapy, and a weakened immune system may be some risk factors associated with the onset of the disease.
Most cases of GBM are diagnosed at an older age with a median age of 64.
Although the disease does not have some specific symptoms, it shares the common symptoms of other types of cancer such as gastrointestinal discomforts accompanied by personality changes, and symptoms similar to those of a stroke.
Most patients with GBM experience symptoms of brain swelling caused by the overexpression of the fluid surrounding the tumor.
Conventionally, due to the nature of rapid growth, surgery is necessary to relieve the brain pressure and remove the tumor as much as possible, followed by radiation and chemotherapy.
According to the statistics, in the US, the incidence affects mostly in the elderly with the diagnosed rate of 3.19 per 100,000 persons. The disease is rare in children.
GBM is deadly, patients with GBM have a median survival of less than one year and less than 2% of patients survive three years or more.
Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.
In finding potential and natural foods that process neuroprotective property, researchers investigated the protective effect of sulforaphane (SFN), an isothiocyanate (ITC) derived from cruciferous vegetables against glioblastoma (GBM) progression.
According to the tested analysis, the application of SFN in GBM showed to induce apoptosis and to inhibit both growth and invasion of GBM cells [78].
Furthermore, SFN can overcome the chemoresistance of tumor cells.
The efficacy of SFN against the progression of glioblastoma (GBM) was attributed to the phytochemicals that can cross the blood-brain barrier (BBB) to reach the tumor mass by inhibiting the functions of MMP-9 in GBM in mediating the BBB alternation.
Furthermore, SFN also demonstrated strong activity in the induction of cancer cell apoptosis and anti-cancer cell proliferation and the protection of healthy neurons.
Moreover, SFN also induces apoptosis of GBM cells by increasing ROS levels in the cancer cells and inhibiting cancer cell migration and/or invasion.
Combination with chemo drug, SFN improved the function of the drug and reduce the chemoresistance of GBM without conferring significant toxicity to normal cells.
Based on the findings, researchers said, " ...the results of these studies support further investigations using SFN in animal models of GBM.
Taken altogether, dietary cruciferous vegetables may be considered functional remedies for the prevention and treatment of GBM, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sulforaphane from Cruciferous Vegetables: Recent Advances to Improve Glioblastoma Treatment by Sita G1, Hrelia P2, Graziosi A3, Morroni F. (PubMed)
Friday 3 November 2023
#Healthyfood #Broccoli Decreases the mRNA Expression of Pro-Inflammatory Cytokines in the Induction of #Colitis, Researchers Suggest
Kyle J. Norton
The colon also is known as the large bowel or large intestine, formed parts of the digestive system in our body.
The colon consists of four parts: descending colon, ascending colon, transverse colon, and sigmoid colon.
The main functions of the colon are to reabsorb fluids and process waste products from the body and prepare for its elimination.
Colitis is medical a condition characterized by the inflammation of the large intestine, including the colon, caecum, and rectum.
Depending on the causes, colitis can be classified into microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis, particularly in those associated with inflammatory bowel disease (IBD), such as ulcerative colitis (UC).
Conventionally, colitis caused by infection is treated by antibiotics. However, treatment of non-infection colitis focuses on symptom relief, supportive care, and maintaining adequate hydration and pain control.
The most common tools used for colitis diagnosis are X-rays of the colon, testing the stool for blood and pus, sigmoidoscopy, and colonoscopy.
Types of colitis according to the Catholic University of the Sacred Heart, include
microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis.
Epidemiologically, people with untreated colitis may experience complications of
* Congenital abnormalities
Women who are pregnant with Ulcerative colitis are associated with a significantly increased risk of some selected congenital abnormalities (limb deficiencies, obstructive urinary, and multiple congenital abnormalities) according to the birth outcomes in women with ulcerative colitis examined in nationwide.
* Nutritional deficiency
Malnutrition, particularly protein-energy malnutrition and vitamin and micronutrient deficiencies, as well as dysregulation of the intestinal microbiota, are common features of IBD.
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
To find natural food for the prevention and treatment of colonic diseases, researchers compared the efficacy of lightly cooked broccoli (CB) containing greatly diminished myrosinase activity, with raw broccoli (RB), in mitigating colitis in dextran sulfate sodium (DSS)-treated mice.
The study included male C57BL/6 mice that were fed for two weeks on a 10% RB, 10% CB, or control diet, all based on the AIN-93M diet with half (n = 9) of each group receiving drinking water, and the other half received 2.5% DSS in water for one week, starting from Day 7 of the diet.
According to the tested analysis,
* CB lessened the damage by DSS, evidenced by a decreased disease activity index comparable to those of RB.
* CB attenuated colon length shrinkage and lowered the endotoxin (lipopolysaccharide) leakage into the blood.
* CB also inhibited the severe colon lesions as assessed by histopathology.
* CB also decreased the mRNA expression of pro-inflammatory cytokines through broccoli's anti-inflammatory action by inhibiting the IL-6 trans-signaling pathway.
In other words, CB protects the integrity of the colon cells against the onset of colitis.
Taken together, broccoli may be considered functional food for the prevention and treatment of colitis, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lightly Cooked Broccoli Is as Effective as Raw Broccoli in Mitigating Dextran Sulfate Sodium-Induced Colitis in Mice by Wang Y1, Jeffery EH2, Miller MJ3, Wallig MA4, Wu Y. (PubMed)
The colon also is known as the large bowel or large intestine, formed parts of the digestive system in our body.
The colon consists of four parts: descending colon, ascending colon, transverse colon, and sigmoid colon.
The main functions of the colon are to reabsorb fluids and process waste products from the body and prepare for its elimination.
Colitis is medical a condition characterized by the inflammation of the large intestine, including the colon, caecum, and rectum.
Depending on the causes, colitis can be classified into microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis, particularly in those associated with inflammatory bowel disease (IBD), such as ulcerative colitis (UC).
Conventionally, colitis caused by infection is treated by antibiotics. However, treatment of non-infection colitis focuses on symptom relief, supportive care, and maintaining adequate hydration and pain control.
The most common tools used for colitis diagnosis are X-rays of the colon, testing the stool for blood and pus, sigmoidoscopy, and colonoscopy.
Types of colitis according to the Catholic University of the Sacred Heart, include
microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis.
Epidemiologically, people with untreated colitis may experience complications of
* Congenital abnormalities
Women who are pregnant with Ulcerative colitis are associated with a significantly increased risk of some selected congenital abnormalities (limb deficiencies, obstructive urinary, and multiple congenital abnormalities) according to the birth outcomes in women with ulcerative colitis examined in nationwide.
* Nutritional deficiency
Malnutrition, particularly protein-energy malnutrition and vitamin and micronutrient deficiencies, as well as dysregulation of the intestinal microbiota, are common features of IBD.
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
To find natural food for the prevention and treatment of colonic diseases, researchers compared the efficacy of lightly cooked broccoli (CB) containing greatly diminished myrosinase activity, with raw broccoli (RB), in mitigating colitis in dextran sulfate sodium (DSS)-treated mice.
The study included male C57BL/6 mice that were fed for two weeks on a 10% RB, 10% CB, or control diet, all based on the AIN-93M diet with half (n = 9) of each group receiving drinking water, and the other half received 2.5% DSS in water for one week, starting from Day 7 of the diet.
According to the tested analysis,
* CB lessened the damage by DSS, evidenced by a decreased disease activity index comparable to those of RB.
* CB attenuated colon length shrinkage and lowered the endotoxin (lipopolysaccharide) leakage into the blood.
* CB also inhibited the severe colon lesions as assessed by histopathology.
* CB also decreased the mRNA expression of pro-inflammatory cytokines through broccoli's anti-inflammatory action by inhibiting the IL-6 trans-signaling pathway.
In other words, CB protects the integrity of the colon cells against the onset of colitis.
Taken together, broccoli may be considered functional food for the prevention and treatment of colitis, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lightly Cooked Broccoli Is as Effective as Raw Broccoli in Mitigating Dextran Sulfate Sodium-Induced Colitis in Mice by Wang Y1, Jeffery EH2, Miller MJ3, Wallig MA4, Wu Y. (PubMed)
The #Cucumber's #Cucurbitacin B (CuB) Hyperglycemic Effect in Diabetics, Resaerchers Show
Kyle J. Norton
Hypoglycemia is abnormally high blood glucose levels in the bloodstream in diabetes.
Most cases of hyperglycemia are associated with poor management of blood sugar levels as a result of poor diet and poor practice of medicine intake and insulin injection.
Hyperglycemia is a hallmark of diabetes caused by the inability of the body to convert glucose to energy or make the hormone insulin.
The most common and early signs of hyperglycemia are increased thirst and/or hunger, frequent urination, sugar in your urine, and fatigue.
In severe cases, patients with hyperglycemia may also experience symptoms of headache and blurred vision.
Long-term untreated hyperglycemia may induce complications that affect the eyes, kidneys, nerves, and heart.
In severe cases, hyperglycemia can also lead to serious complications that require emergency care, such as a diabetic coma.
Women who are nondiabetics before pregnancy and experience gestation hyperglycemia are likely to develop diabetes in the latter days.
Believe it or not, hyperglycemia can also occur in people without diabetes due to stress. According to the study, people who are nondiabetics and experience abnormally high blood glucose are most likely to develop diabetes later in life.
According to the statistics, In 2015, approximately 30.3 million Americans, or 9.4% of the population, had diabetes. Approximately 1.25 million American children and adults have type 1 diabetes.
Some researchers suggested that by changing lifestyle with moderate exercise, hyperglycemia can be manageable in type II diabetes.
Dr. Salwa W. Rizkalla wrote, " Only 4 weeks of a (low GI diet) LGI diet was able to improve glycemic control, glucose utilization, some lipid profiles, and the capacity for fibrinolysis in type 2 diabetes. Even if changes in glycemic control were modest during the 4 weeks, the use of an LGI diet in a longer-term manner might play an important role in the treatment and prevention of diabetes and related disorders"
The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.
To find a natural ingredient for the prevention of hyperglycemia in patients with diabetes, researchers examined the effect of Cucurbitacin B (CuB) isolated from cucumber-induced hypoglycemic effect in an animal model.
On mice-induced diabetes, administration of Cucurbitacin B (CuB) composed of triterpenoid structure stimulated the AMP-activated protein kinase (AMPK) pathway which has been found to contribute to the correction of insulin resistance overexpression in hyperglycemia.
CuB also ameliorated hyperglycemia not only by activating intestinal AMPK levels but also by inducing the production of plasma GLP-1 associated with the improvement of insulin-releasing by pancreatic β-cells.
However, GLP-1 mimetic medicines although exert a similar effect compared to that of natural GLP-1, induce clinical side effects, such as autoimmune hepatitis, acute kidney injury, pancreatitis, and pancreatic cancer.
Interestingly, the efficacy of the hypoglycemic activity of CuB decreased significantly in dorsomorphin- (a selective inhibitor of the BMP pathway involved in the expression of cytokines) injected mice and α-gustducin null mice.
In differentiated NCI-H716 cell line, CuB inhibited hyperglycemia involved in the activation of AMPK through α-gustducin and Gβγ-signaling of taste receptors in signaling secretion of incretin hormones such as glucagon-like peptide-1 (GLP-1).
Taste receptors are found in several organs including the tongue to colon and have diverse functions dependent on specific cell types.
In enteroendocrine L cells, stimulated taste receptor signaling plays a critical role in inducing incretin hormones, including GLP-1.
Based on the findings, researchers said, "CuB represents novel hypoglycemic agents by activation of AMPK and stimulation of GLP-1 in differentiated enteroendocrine L-cells".
Taken together, cucumber-processed high levels of CuB may be used for the treatment of hyperglycemia in diabetics, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling by Kim KH1,2, Lee IS1,2, Park JY1,2, Kim Y1,2, An EJ1,2, Jang HJ. (PubMed)
(2) Improved Plasma Glucose Control, Whole-Body Glucose Utilization, and Lipid Profile on a Low-Glycemic Index Diet in Type 2 Diabetic Men by
Salwa W. Rizkalla, MD, PHD12,
Laika Taghrid, MD1,
Muriel Laromiguiere, PharmD, PHD3,
Dorothée Huet, MD1,
Josette Boillot, PHD1,
Aude Rigoir, RN1,
Fabienne Elgrably, MD1 and
Gerard Slama, MD. (the American Diabetes Association)
Hypoglycemia is abnormally high blood glucose levels in the bloodstream in diabetes.
Most cases of hyperglycemia are associated with poor management of blood sugar levels as a result of poor diet and poor practice of medicine intake and insulin injection.
Hyperglycemia is a hallmark of diabetes caused by the inability of the body to convert glucose to energy or make the hormone insulin.
The most common and early signs of hyperglycemia are increased thirst and/or hunger, frequent urination, sugar in your urine, and fatigue.
In severe cases, patients with hyperglycemia may also experience symptoms of headache and blurred vision.
Long-term untreated hyperglycemia may induce complications that affect the eyes, kidneys, nerves, and heart.
In severe cases, hyperglycemia can also lead to serious complications that require emergency care, such as a diabetic coma.
Women who are nondiabetics before pregnancy and experience gestation hyperglycemia are likely to develop diabetes in the latter days.
Believe it or not, hyperglycemia can also occur in people without diabetes due to stress. According to the study, people who are nondiabetics and experience abnormally high blood glucose are most likely to develop diabetes later in life.
According to the statistics, In 2015, approximately 30.3 million Americans, or 9.4% of the population, had diabetes. Approximately 1.25 million American children and adults have type 1 diabetes.
Some researchers suggested that by changing lifestyle with moderate exercise, hyperglycemia can be manageable in type II diabetes.
Dr. Salwa W. Rizkalla wrote, " Only 4 weeks of a (low GI diet) LGI diet was able to improve glycemic control, glucose utilization, some lipid profiles, and the capacity for fibrinolysis in type 2 diabetes. Even if changes in glycemic control were modest during the 4 weeks, the use of an LGI diet in a longer-term manner might play an important role in the treatment and prevention of diabetes and related disorders"
The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.
To find a natural ingredient for the prevention of hyperglycemia in patients with diabetes, researchers examined the effect of Cucurbitacin B (CuB) isolated from cucumber-induced hypoglycemic effect in an animal model.
On mice-induced diabetes, administration of Cucurbitacin B (CuB) composed of triterpenoid structure stimulated the AMP-activated protein kinase (AMPK) pathway which has been found to contribute to the correction of insulin resistance overexpression in hyperglycemia.
CuB also ameliorated hyperglycemia not only by activating intestinal AMPK levels but also by inducing the production of plasma GLP-1 associated with the improvement of insulin-releasing by pancreatic β-cells.
However, GLP-1 mimetic medicines although exert a similar effect compared to that of natural GLP-1, induce clinical side effects, such as autoimmune hepatitis, acute kidney injury, pancreatitis, and pancreatic cancer.
Interestingly, the efficacy of the hypoglycemic activity of CuB decreased significantly in dorsomorphin- (a selective inhibitor of the BMP pathway involved in the expression of cytokines) injected mice and α-gustducin null mice.
In differentiated NCI-H716 cell line, CuB inhibited hyperglycemia involved in the activation of AMPK through α-gustducin and Gβγ-signaling of taste receptors in signaling secretion of incretin hormones such as glucagon-like peptide-1 (GLP-1).
Taste receptors are found in several organs including the tongue to colon and have diverse functions dependent on specific cell types.
In enteroendocrine L cells, stimulated taste receptor signaling plays a critical role in inducing incretin hormones, including GLP-1.
Based on the findings, researchers said, "CuB represents novel hypoglycemic agents by activation of AMPK and stimulation of GLP-1 in differentiated enteroendocrine L-cells".
Taken together, cucumber-processed high levels of CuB may be used for the treatment of hyperglycemia in diabetics, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling by Kim KH1,2, Lee IS1,2, Park JY1,2, Kim Y1,2, An EJ1,2, Jang HJ. (PubMed)
(2) Improved Plasma Glucose Control, Whole-Body Glucose Utilization, and Lipid Profile on a Low-Glycemic Index Diet in Type 2 Diabetic Men by
Salwa W. Rizkalla, MD, PHD12,
Laika Taghrid, MD1,
Muriel Laromiguiere, PharmD, PHD3,
Dorothée Huet, MD1,
Josette Boillot, PHD1,
Aude Rigoir, RN1,
Fabienne Elgrably, MD1 and
Gerard Slama, MD. (the American Diabetes Association)
#Ginger Inhibits Stress Markers Associated with the Risk and Onset of Type 2 #Diabetes, Scientists Say
Kyle J. Norton
Ginger may be next generation whole food used for the prevention and treatment of type 2 diabetes, with no side effects, some scientists suggested.
Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose due to either cell in pancreas dying off or receptor sites clogged up by fat and cholesterol.
Researchers do not know what causes the pancreas to die off or receptor sites to clog up. However, they do know obesity or overweight, gender, ethnicity, age, family history, gestation diabetes, are associated with an increased risk of type 2 diabetes.
Some researchers also suggested that people with certain medical conditions such as polycystic ovary syndrome. and high blood pressure is more prone to the onset of the disease.
The most common symptoms of type 2 diabetes are increased thirst that won't stop with water intake, increased hunger (especially after eating), dry mouth, frequent urination, and unintentional weight loss.
If you experience some of the symptoms above, please make you check with your doctor to rule out the possibility of diabetes.
According to statistics, diabetes is one of the most common diseases in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million that are undiagnosed and unaware of their condition.
About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.
Dr. Rita R. Kalyani in the study to examine the increase with age and risk of type 2 diabetes wrote, "The unprecedented aging of the world's population is a major contributor to the diabetes epidemic, and older adults represent one of the fastest-growing segments of the diabetes population".
"Almost one-third of U.S. adults over the age of 65 years have diabetes. Approximately half of those are undiagnosed, and an additional one-third of older adults have prediabetes" and "management of older adults with diabetes is clearly more complicated given the observation that they commonly have multiple coexisting medical conditions that can impact clinical management".
Compared to the general population risk of type 2 diabetes, the results clearly stated, the risk of type diabetes in elderly is 3 fold higher and the management of the disease is more difficult due accompanied by other medical conditions, such as high blood pressure and cholesterol
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
To find a natural whole food for the prevention and treatment of diabetes with little or no side effects, researchers looked into the effects of ginger consumption on glycemic status, lipid profile, and some inflammatory markers in patients with type 2 diabetes mellitus.
The double-blinded, placebo-controlled clinical trial, included 70 types 2 diabetic patients allocated randomly into the ginger group consumed 1600 mg of ginger, and the control group consumed 1600 mg of wheat flour daily for 12 weeks.
Patients treated with ginger demonstrated a significant effect in reducing the levels of fasting plasma glucose, 3 months average glucose concentration, and insulin resistance.
Furthermore, the blood profile of the treatment group also displayed lower levels of triglyceride, total cholesterol, a hormone associated with lipid peroxidation. compared to the placebo group.
There were no significant differences in high-density lipoprotein (HDL), low-density lipoprotein LDL, and TNFα, the inflammatory cytokine between the two groups.
The findings firmly indicated ginger improves insulin sensitivity and some fractions of lipid profiles and reduces inflammation in type 2 diabetic patients.
Additionally, intending to reaffirm the effects of ginger against the development of type 2 diabetes and diabetic complications, researchers investigated the effect of ginger supplementation on glycemic indices in Iranian patients with type 2 diabetes.
The double-blind, placebo-controlled, randomized clinical trial included 20-60 -year-old patients with type 2 diabetes who did not receive insulin.
Participants in the intervention and control groups received 3 g of powdered ginger or placebo (lactose) (in capsules) daily for 3 months.
At the end of the 3 months, researchers showed that all parameters associated with diabetes were reduced substantially in the treatment group compared to control.
More precisely, the differences between the ginger and placebo groups were statistically significant as follows: serum glucose (-19.41 ± 18.83 vs. 1.63 ± 4.28 mg/dL, p < 0.001), (Hemoglobin A1C)HbA1c percentage (-0.77 ± 0.88 vs. 0.02 ± 0.16%, p < 0.001), insulin (-1.46 ± 1.7 vs. 0.09 ± 0.34 μIU/mL, p < 0.001), insulin resistance (-16.38 ± 19.2 vs. 0.68 ± 2.7, p < 0.001), high-sensitive CRP (-2.78 ± 4.07 vs. 0.2 ± 0.77 mg/L, p < 0.001), paraoxonase-1 (PON-1) (22.04 ± 24.53 vs. 1.71 ± 2.72 U/L, p < 0.006), total antioxidant capacity (TAC) (0.78 ± 0.71 vs. -0.04 ± 0.29 µIU/mL, p < 0.01) and MDA (-0.85 ± 1.08 vs. 0.06 ± 0.08 µmol/L, p < 0.001) were significantly different.
Where paraoxonase ((PON)-1 is an enzyme associated with the protection against lipid oxidation, Malondialdehyde (MDA) is an oxidative stress marker.
Dr. Shidfar F, the lead scientist said, "The 3 months supplementation of ginger improved glycemic indices, TAC, and PON-1 activity in patients with type 2 diabetes".
Taken together, ginger may be considered a functional food for the prevention and combined with the primary therapy for the treatment of type 2 diabetes with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus by Arablou T1, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. (PubMed)
(2) Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients by Mahluji S1, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. (PubMed)
(3) The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes by Shidfar F, Rajab A, Rahideh T, Khandouzi N, Hosseini S, Shidfar S. (PubMed)
(4) Diabetes and Aging: Unique Considerations and Goals of Care, Rita R. Kalyani, Sherita H. Golden and William T. Cefalu. (Diabetes Care)
Ginger may be next generation whole food used for the prevention and treatment of type 2 diabetes, with no side effects, some scientists suggested.
Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose due to either cell in pancreas dying off or receptor sites clogged up by fat and cholesterol.
Researchers do not know what causes the pancreas to die off or receptor sites to clog up. However, they do know obesity or overweight, gender, ethnicity, age, family history, gestation diabetes, are associated with an increased risk of type 2 diabetes.
Some researchers also suggested that people with certain medical conditions such as polycystic ovary syndrome. and high blood pressure is more prone to the onset of the disease.
The most common symptoms of type 2 diabetes are increased thirst that won't stop with water intake, increased hunger (especially after eating), dry mouth, frequent urination, and unintentional weight loss.
If you experience some of the symptoms above, please make you check with your doctor to rule out the possibility of diabetes.
According to statistics, diabetes is one of the most common diseases in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million that are undiagnosed and unaware of their condition.
About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.
Dr. Rita R. Kalyani in the study to examine the increase with age and risk of type 2 diabetes wrote, "The unprecedented aging of the world's population is a major contributor to the diabetes epidemic, and older adults represent one of the fastest-growing segments of the diabetes population".
"Almost one-third of U.S. adults over the age of 65 years have diabetes. Approximately half of those are undiagnosed, and an additional one-third of older adults have prediabetes" and "management of older adults with diabetes is clearly more complicated given the observation that they commonly have multiple coexisting medical conditions that can impact clinical management".
Compared to the general population risk of type 2 diabetes, the results clearly stated, the risk of type diabetes in elderly is 3 fold higher and the management of the disease is more difficult due accompanied by other medical conditions, such as high blood pressure and cholesterol
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
To find a natural whole food for the prevention and treatment of diabetes with little or no side effects, researchers looked into the effects of ginger consumption on glycemic status, lipid profile, and some inflammatory markers in patients with type 2 diabetes mellitus.
The double-blinded, placebo-controlled clinical trial, included 70 types 2 diabetic patients allocated randomly into the ginger group consumed 1600 mg of ginger, and the control group consumed 1600 mg of wheat flour daily for 12 weeks.
Patients treated with ginger demonstrated a significant effect in reducing the levels of fasting plasma glucose, 3 months average glucose concentration, and insulin resistance.
Furthermore, the blood profile of the treatment group also displayed lower levels of triglyceride, total cholesterol, a hormone associated with lipid peroxidation. compared to the placebo group.
There were no significant differences in high-density lipoprotein (HDL), low-density lipoprotein LDL, and TNFα, the inflammatory cytokine between the two groups.
The findings firmly indicated ginger improves insulin sensitivity and some fractions of lipid profiles and reduces inflammation in type 2 diabetic patients.
Additionally, intending to reaffirm the effects of ginger against the development of type 2 diabetes and diabetic complications, researchers investigated the effect of ginger supplementation on glycemic indices in Iranian patients with type 2 diabetes.
The double-blind, placebo-controlled, randomized clinical trial included 20-60 -year-old patients with type 2 diabetes who did not receive insulin.
Participants in the intervention and control groups received 3 g of powdered ginger or placebo (lactose) (in capsules) daily for 3 months.
At the end of the 3 months, researchers showed that all parameters associated with diabetes were reduced substantially in the treatment group compared to control.
More precisely, the differences between the ginger and placebo groups were statistically significant as follows: serum glucose (-19.41 ± 18.83 vs. 1.63 ± 4.28 mg/dL, p < 0.001), (Hemoglobin A1C)HbA1c percentage (-0.77 ± 0.88 vs. 0.02 ± 0.16%, p < 0.001), insulin (-1.46 ± 1.7 vs. 0.09 ± 0.34 μIU/mL, p < 0.001), insulin resistance (-16.38 ± 19.2 vs. 0.68 ± 2.7, p < 0.001), high-sensitive CRP (-2.78 ± 4.07 vs. 0.2 ± 0.77 mg/L, p < 0.001), paraoxonase-1 (PON-1) (22.04 ± 24.53 vs. 1.71 ± 2.72 U/L, p < 0.006), total antioxidant capacity (TAC) (0.78 ± 0.71 vs. -0.04 ± 0.29 µIU/mL, p < 0.01) and MDA (-0.85 ± 1.08 vs. 0.06 ± 0.08 µmol/L, p < 0.001) were significantly different.
Where paraoxonase ((PON)-1 is an enzyme associated with the protection against lipid oxidation, Malondialdehyde (MDA) is an oxidative stress marker.
Dr. Shidfar F, the lead scientist said, "The 3 months supplementation of ginger improved glycemic indices, TAC, and PON-1 activity in patients with type 2 diabetes".
Taken together, ginger may be considered a functional food for the prevention and combined with the primary therapy for the treatment of type 2 diabetes with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus by Arablou T1, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. (PubMed)
(2) Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients by Mahluji S1, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. (PubMed)
(3) The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes by Shidfar F, Rajab A, Rahideh T, Khandouzi N, Hosseini S, Shidfar S. (PubMed)
(4) Diabetes and Aging: Unique Considerations and Goals of Care, Rita R. Kalyani, Sherita H. Golden and William T. Cefalu. (Diabetes Care)
#Healthyfood #Tomato Inhibits the Risk and #Onset of Digestive-Tract Cancer, Researchers Show
Kyle J. Norton
Digestive-tract formed part of the digestive system is a series of hollow organs joined in a long, twisting tube from the mouth to the anus and plays a critical role to absorb the nutrient from the food intake to the blood before passing them to other parts of the body.
Cancers are a class of diseases characterized by irregular cell growth in the body tissue.
Most cases of digestive tract cancer start in the cell on the surface of the inner lining of the gastrointestinal tissue before penetrating into deeper layers and colonizing the entire organ.
Colon cancer is one of the most common and slow-growing cancers in the digestive tract that
According to the statistics provided by the American Cancer Society, in 2019, 95,520 people will be diagnosed with colon cancer. Colon cancer will also cause the death of 50,260 patients in the same year.
The 5 years survival rate of colon cancer diagnosed at the localized stage is 90%.
The most common signs of digestive tract cancer include abdominal pain, blood in the stool due to bleeding, and a noticeable lump in the abdomen accompanied by the general symptoms shared with other types of cancer such as unexplained weight loss, weakness or fatigue gastrointestinal discomfort, and loss of appetite.
If you have experienced some of the aforementioned symptoms with no signs of stopping, please make sure you check with your doctor to rule out the possibility.
WHO in the examination of diet in cancer risk wrote, "Cancer is the most important cause of death after diseases of the circulatory system. It accounts for 20% of all deaths in the Region, with 2.5 million new cases diagnosed each year".
And, "A large body of literature indicates that as much as 30% of all cancer cases are linked to poor dietary habits, and is therefore preventable. The proportion reaches 70% for cancers of the gastrointestinal tract".
In other words, poor diet is one of the major causes of gastrointestinal cancer worldwide.
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to find a potential compound for the treatment of digestive tract cancer, researchers examined the relationship between tomato intake and the risk of digestive tract cancer.
According to the data from a series of case-control studies conducted in Italy between 1983 and 1992, over the period, 317 incident cases of cancer of the oral cavity and pharynx, 85 of the esophagus, 723 of the stomach, 955 of the colon, and 629 of the rectum, were diagnosed compared to a total of 2879 controls admitted for acute, non-neoplastic conditions, unrelated to long-term modifications of diet.
The ORs for the highest tomato consumption quartile were 0.65 (95% CI 0.4-1.0) for oral cavity, pharynx, and esophagus, 0.43 (95% CI 0.3-0.6) for stomach, 0.39 (95% CI 0.3-0.5) for colon, and 0.42 (95% CI 0.3-0.6) for rectum.
The ORs of colorectal cancer for the highest consumption quintile were 0.79 (95% CI 0.6-0.9) for colon and 0.71 (95% CI 0.5-0.9) for rectal cancer, according to another study of colorectal cancer, based on 1,953 cases and 4,154 controls, conducted between 1992 and 1996, using a more detailed food frequency questionnaire.
The findings strongly suggested that a long-term high amount of tomato consumption has a strong impact on the risk of digestive tract cancer, regardless of several potential confounding factors, including measures of body mass index, calorie intake, and physical activity.
Furthermore, to examine the additional information about tomato anti-digestive-tract cancers, researchers investigated the effect of tomatoes on the risk of digestive tract tumors based on an integrated series of case-control studies conducted between 1985 and 1991 in northern Italy, where tomato intake is high but, also, heterogeneous.
For 7 years, the oral cavity and pharynx, 314; the esophagus, 85; stomach, 723; colon, 955; and rectum, 629 were diagnosed compared to a total of 2,879 controls admitted to the hospital for acute non-neoplastic or non-digestive conditions, unrelated to long-term dietary modifications.
The OR of digestive tract cancers in the upper quartile was ranging between 0.4 and 0.7 compared to the baseline.
Researchers after allowance for age, sex, study center, education, smoking, drinking level, and tertile of total caloric intake into account said, "The beneficial effect of raw tomatoes in this population may be partly since they constitute perhaps the most specific feature of the Mediterranean diet".
And, " However, if it is true that tomatoes protect against digestive tract cancers, this is of interest from both a scientific and a public health viewpoint".
Taken together, tomatoes may be considered supplements for the prevention and treatment of digestive tract cancers, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Mediterranean epidemiological evidence on tomatoes and the prevention of digestive-tract cancers by La Vecchia C. (PubMed)
(2) Tomatoes and risk of digestive-tract cancers by Franceschi S1, Bidoli E, La Vecchia C, Talamini R, D'Avanzo B, Negri E. (PubMed)
(3) Cancer linked with poor nutrition by WHO
Digestive-tract formed part of the digestive system is a series of hollow organs joined in a long, twisting tube from the mouth to the anus and plays a critical role to absorb the nutrient from the food intake to the blood before passing them to other parts of the body.
Cancers are a class of diseases characterized by irregular cell growth in the body tissue.
Most cases of digestive tract cancer start in the cell on the surface of the inner lining of the gastrointestinal tissue before penetrating into deeper layers and colonizing the entire organ.
Colon cancer is one of the most common and slow-growing cancers in the digestive tract that
According to the statistics provided by the American Cancer Society, in 2019, 95,520 people will be diagnosed with colon cancer. Colon cancer will also cause the death of 50,260 patients in the same year.
The 5 years survival rate of colon cancer diagnosed at the localized stage is 90%.
The most common signs of digestive tract cancer include abdominal pain, blood in the stool due to bleeding, and a noticeable lump in the abdomen accompanied by the general symptoms shared with other types of cancer such as unexplained weight loss, weakness or fatigue gastrointestinal discomfort, and loss of appetite.
If you have experienced some of the aforementioned symptoms with no signs of stopping, please make sure you check with your doctor to rule out the possibility.
WHO in the examination of diet in cancer risk wrote, "Cancer is the most important cause of death after diseases of the circulatory system. It accounts for 20% of all deaths in the Region, with 2.5 million new cases diagnosed each year".
And, "A large body of literature indicates that as much as 30% of all cancer cases are linked to poor dietary habits, and is therefore preventable. The proportion reaches 70% for cancers of the gastrointestinal tract".
In other words, poor diet is one of the major causes of gastrointestinal cancer worldwide.
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to find a potential compound for the treatment of digestive tract cancer, researchers examined the relationship between tomato intake and the risk of digestive tract cancer.
According to the data from a series of case-control studies conducted in Italy between 1983 and 1992, over the period, 317 incident cases of cancer of the oral cavity and pharynx, 85 of the esophagus, 723 of the stomach, 955 of the colon, and 629 of the rectum, were diagnosed compared to a total of 2879 controls admitted for acute, non-neoplastic conditions, unrelated to long-term modifications of diet.
The ORs for the highest tomato consumption quartile were 0.65 (95% CI 0.4-1.0) for oral cavity, pharynx, and esophagus, 0.43 (95% CI 0.3-0.6) for stomach, 0.39 (95% CI 0.3-0.5) for colon, and 0.42 (95% CI 0.3-0.6) for rectum.
The ORs of colorectal cancer for the highest consumption quintile were 0.79 (95% CI 0.6-0.9) for colon and 0.71 (95% CI 0.5-0.9) for rectal cancer, according to another study of colorectal cancer, based on 1,953 cases and 4,154 controls, conducted between 1992 and 1996, using a more detailed food frequency questionnaire.
The findings strongly suggested that a long-term high amount of tomato consumption has a strong impact on the risk of digestive tract cancer, regardless of several potential confounding factors, including measures of body mass index, calorie intake, and physical activity.
Furthermore, to examine the additional information about tomato anti-digestive-tract cancers, researchers investigated the effect of tomatoes on the risk of digestive tract tumors based on an integrated series of case-control studies conducted between 1985 and 1991 in northern Italy, where tomato intake is high but, also, heterogeneous.
For 7 years, the oral cavity and pharynx, 314; the esophagus, 85; stomach, 723; colon, 955; and rectum, 629 were diagnosed compared to a total of 2,879 controls admitted to the hospital for acute non-neoplastic or non-digestive conditions, unrelated to long-term dietary modifications.
The OR of digestive tract cancers in the upper quartile was ranging between 0.4 and 0.7 compared to the baseline.
Researchers after allowance for age, sex, study center, education, smoking, drinking level, and tertile of total caloric intake into account said, "The beneficial effect of raw tomatoes in this population may be partly since they constitute perhaps the most specific feature of the Mediterranean diet".
And, " However, if it is true that tomatoes protect against digestive tract cancers, this is of interest from both a scientific and a public health viewpoint".
Taken together, tomatoes may be considered supplements for the prevention and treatment of digestive tract cancers, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Mediterranean epidemiological evidence on tomatoes and the prevention of digestive-tract cancers by La Vecchia C. (PubMed)
(2) Tomatoes and risk of digestive-tract cancers by Franceschi S1, Bidoli E, La Vecchia C, Talamini R, D'Avanzo B, Negri E. (PubMed)
(3) Cancer linked with poor nutrition by WHO
#FennelExtract Inhibits Neurotoxicity Against The Onset of Cognitive Impairment, Scientists Suggest
Kyle J. Norton
Fennel may process a sustainable and therapeutic effect in enhancing cognitive functions, some scientists suggested.
Cognitive function is a mental process of the brain, intending to acquire knowledge by accumulating information through reasoning, memory, attention, and language, regardless of circumstances.
On the other hand, cognitive impairment, depending on the severity is a condition in which the infected person has trouble remembering, learning new things, concentrating, or making decisions that affect the quality of their everyday life.
In the elderly, most cases of cognitive impairment are associated with neurodegenerative diseases and long-term use of medication, including Alzheimer's disease.
However, malnutrition, hormone imbalance such as thyroid hormone, mental illness, and substance abuse, particularly, in brain damage or injury are some of the major and prevalent risk factors that can cause the early onset of cognitive impairment.
Some researchers suggested that for people who have metabolic syndrome (abnormally high blood pressure, high blood sugar, obesity, and abnormal cholesterol or triglyceride levels), mental illness, and previously disturbed state of mind due to fever, intoxication is also at a higher risk of the condition develops.
Dr. Fernando Gómez-Pinilla, in the study of the effects of nutrients on brain function, wrote. "diets that are high in saturated fat are becoming notorious for reducing molecular substrates that support cognitive processing and increasing the risk of neurological dysfunction in both humans and animals"
And, Dr. Alan J. Gow, the lead scientist, in the study of the effects of lifestyle on cognitive impairment, said, " Lifestyle factors, particularly those which are malleable across the life course, may be highly informative for the development of interventions to reduce or delay age-related cognitive decline".
These explanations strongly agree that following a healthy diet with plenty of fruits and vegetables and less saturated and trans fat, processed meat, refined products,...... salt, and sugar, and a lifestyle with moderate exercise may have a significant effect in protecting the brain neurons against the onset of cognitive impairment.
Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
.
Anethole, the main fragrance and bioactive compound of fennel, in the study of 20 other plant species was found to process nootropic activity in protecting the degeneration of the neurons, including diseases associated with a decline in cognitive abilities such as Alzheimer's disease through its anti-inflammatory and neuroprotective expression.
In the inflammatory expression, the application of anethole exerted a significant effect in mediated NF-kB in the systematic inflammatory response induced by transcription of proinflammatory genes and TNF-α signaling in the production of inflammatory factors in the acute phase of infection.
The initiation of the pro-inflammatory cytokine in the case of acute infection is a natural defense of the immune response to protect the injured tissue against the invasion of bacteria and viruses. However, overexpression of inflammatory factors may also catalyze tissue damage and cause neuron cell death.
From an oxidative perspective, the application of anethole in the tested model also demonstrated a strong effect in inhibiting reactive oxygen species ROS which cause the cytotoxicity to neuron through its antioxidant and stimulated the production of the host antioxidant defense.
Injection of anethole also rebalanced the ratio of levels of free radicals and antioxidants, thus reducing the risk of the initiated production of pro-inflammatory cytokines in the precipitation of the death of the brain cell that controls memory or other cognitive functions.
Furthermore, in the evaluated fennel effect in Alzheimer's disease, a neurodegenerative disorder associated with a decline in cognitive abilities, researchers found that fennel intake exerts a strong neuroprotective effect in protecting against progressive degeneration.
The methanol extract of the whole plant of F. vulgare administered for eight successive days ameliorated the deficit of memory caused by brain damage, disease, or psychological trauma induced by scopolamine and aging-induced memory deficits in mice.
In acetylcholinesterase AChE-induced neurotoxicity in mice, the application of extract also increased step-down latency and reserved the neuron damage caused by acetylcholinesterase AChE toxicity.
Dr. Preksha Dwivedi, the lead author, after taking into account other co and confounders said, "Foeniculum vulgare Linn. The extract is used as a nootropic and anticholinesterase agent in mice. F. vulgare extract increased step-down latency and acetylcholinesterase inhibition in mice significantly. F. vulgare is employed in the treatment of cognitive disorders such as dementia and Alzheimer's disease".
Taken together, fennel, fennel extracts, or its bioactive anethole may be considered a functional food for enhancing memory or other cognitive functions through its neuroprotective and nootropic activity. However, intake of fennel extracts should be taken with extreme care in the prevention of acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cholinergic basis of memory-strengthening effect of Foeniculum vulgare Linn by Joshi H1, Parle M.(PubMed)
(2) A TRADITIONAL APPROACH TO HERBAL NOOTROPIC AGENTS: AN OVERVIEW Preksha Dwivedi, Richa Singh, Mohd.Tabish Malik and Talha Jawaid(International Journal of Pharmaceutical Science and Research)
(5) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
(4) Anethole and Its Role in Chronic Diseases by Aprotosoaie AC1, Costache II2, Miron A3.(PubMed)
(5) Brain foods: the effects of nutrients on brain function by Fernando Gómez-Pinilla. (PMC)
(6) Lifestyle Factors and Cognitive Ageing: Variation across Ability and Lifestyle Domains by Alan J. Gow, Allison A. M. Bielak, and Denis Gerstorf. (PMC)
Fennel may process a sustainable and therapeutic effect in enhancing cognitive functions, some scientists suggested.
Cognitive function is a mental process of the brain, intending to acquire knowledge by accumulating information through reasoning, memory, attention, and language, regardless of circumstances.
On the other hand, cognitive impairment, depending on the severity is a condition in which the infected person has trouble remembering, learning new things, concentrating, or making decisions that affect the quality of their everyday life.
In the elderly, most cases of cognitive impairment are associated with neurodegenerative diseases and long-term use of medication, including Alzheimer's disease.
However, malnutrition, hormone imbalance such as thyroid hormone, mental illness, and substance abuse, particularly, in brain damage or injury are some of the major and prevalent risk factors that can cause the early onset of cognitive impairment.
Some researchers suggested that for people who have metabolic syndrome (abnormally high blood pressure, high blood sugar, obesity, and abnormal cholesterol or triglyceride levels), mental illness, and previously disturbed state of mind due to fever, intoxication is also at a higher risk of the condition develops.
Dr. Fernando Gómez-Pinilla, in the study of the effects of nutrients on brain function, wrote. "diets that are high in saturated fat are becoming notorious for reducing molecular substrates that support cognitive processing and increasing the risk of neurological dysfunction in both humans and animals"
And, Dr. Alan J. Gow, the lead scientist, in the study of the effects of lifestyle on cognitive impairment, said, " Lifestyle factors, particularly those which are malleable across the life course, may be highly informative for the development of interventions to reduce or delay age-related cognitive decline".
These explanations strongly agree that following a healthy diet with plenty of fruits and vegetables and less saturated and trans fat, processed meat, refined products,...... salt, and sugar, and a lifestyle with moderate exercise may have a significant effect in protecting the brain neurons against the onset of cognitive impairment.
Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
.
Anethole, the main fragrance and bioactive compound of fennel, in the study of 20 other plant species was found to process nootropic activity in protecting the degeneration of the neurons, including diseases associated with a decline in cognitive abilities such as Alzheimer's disease through its anti-inflammatory and neuroprotective expression.
In the inflammatory expression, the application of anethole exerted a significant effect in mediated NF-kB in the systematic inflammatory response induced by transcription of proinflammatory genes and TNF-α signaling in the production of inflammatory factors in the acute phase of infection.
The initiation of the pro-inflammatory cytokine in the case of acute infection is a natural defense of the immune response to protect the injured tissue against the invasion of bacteria and viruses. However, overexpression of inflammatory factors may also catalyze tissue damage and cause neuron cell death.
From an oxidative perspective, the application of anethole in the tested model also demonstrated a strong effect in inhibiting reactive oxygen species ROS which cause the cytotoxicity to neuron through its antioxidant and stimulated the production of the host antioxidant defense.
Injection of anethole also rebalanced the ratio of levels of free radicals and antioxidants, thus reducing the risk of the initiated production of pro-inflammatory cytokines in the precipitation of the death of the brain cell that controls memory or other cognitive functions.
Furthermore, in the evaluated fennel effect in Alzheimer's disease, a neurodegenerative disorder associated with a decline in cognitive abilities, researchers found that fennel intake exerts a strong neuroprotective effect in protecting against progressive degeneration.
The methanol extract of the whole plant of F. vulgare administered for eight successive days ameliorated the deficit of memory caused by brain damage, disease, or psychological trauma induced by scopolamine and aging-induced memory deficits in mice.
In acetylcholinesterase AChE-induced neurotoxicity in mice, the application of extract also increased step-down latency and reserved the neuron damage caused by acetylcholinesterase AChE toxicity.
Dr. Preksha Dwivedi, the lead author, after taking into account other co and confounders said, "Foeniculum vulgare Linn. The extract is used as a nootropic and anticholinesterase agent in mice. F. vulgare extract increased step-down latency and acetylcholinesterase inhibition in mice significantly. F. vulgare is employed in the treatment of cognitive disorders such as dementia and Alzheimer's disease".
Taken together, fennel, fennel extracts, or its bioactive anethole may be considered a functional food for enhancing memory or other cognitive functions through its neuroprotective and nootropic activity. However, intake of fennel extracts should be taken with extreme care in the prevention of acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cholinergic basis of memory-strengthening effect of Foeniculum vulgare Linn by Joshi H1, Parle M.(PubMed)
(2) A TRADITIONAL APPROACH TO HERBAL NOOTROPIC AGENTS: AN OVERVIEW Preksha Dwivedi, Richa Singh, Mohd.Tabish Malik and Talha Jawaid(International Journal of Pharmaceutical Science and Research)
(5) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
(4) Anethole and Its Role in Chronic Diseases by Aprotosoaie AC1, Costache II2, Miron A3.(PubMed)
(5) Brain foods: the effects of nutrients on brain function by Fernando Gómez-Pinilla. (PMC)
(6) Lifestyle Factors and Cognitive Ageing: Variation across Ability and Lifestyle Domains by Alan J. Gow, Allison A. M. Bielak, and Denis Gerstorf. (PMC)
#GelamHoney and #GingerExtract Used Alone Or Combination Process a Strong Anti-Colon Cancer Activity, Researchers Say
Kyle J. Norton
Scientists may have found a sweet functional food that processes the potential for the prevention and treatment of cancer, some studies suggested.
Cancers are a group of chronic diseases, caused by cell growth and uncontrollably in some specific tissues and organs.
Most primary cancers start in the cells on the surface of the inner lining of tissue caused by the alternation of DNA.
At the later stage, after penetrating deep into the tissue of the infected organs, most primary cancers can travel a distance away from the original site to damage other healthy tissue and organs.
As they grow large enough, they can also suppress the nearby tissue and nerve cells, causing severe pain and localized symptoms.
Researchers do not know the exact causes of colon cancer. Neither do they know why some people have the same health conditions, diet patterns ethnicity, and family history, some are susceptible to the early onset of the diseases, while many others are not.
The most common risk factors, epidemiologically are associated with the types of cancer. The National Cancer Institute suggested that aging, tobacco, long-term sun and radiation exposure, chemicals and other substances, some viruses and bacteria, certain hormones, family history of cancer, alcohol, poor diet, lack of physical activity, or being overweight are the common causes of cancer.
In the challenges, the idea that cancer cannot be prevented among older adults, researchers at the National Center for Chronic Disease Prevention and Health Promotion launched a study by examining different aspects of the relationship between age and cancer said, "Although the sequential patterns of aging cannot be changed, several age-related factors that contribute to disease risk can be".
What are the age-related factors that contribute to cancer changes? researchers continued. "For most adults, age is coincidentally associated with preventable chronic conditions, avoidable exposures, and modifiable risk behaviors that are causally associated with cancer", and "current evidence suggests that for most adults, cancer does not have to be an inevitable consequence of growing older. Interventions that support healthy environments, help people manage chronic conditions, and promote healthy behaviors may help people make a healthier transition from midlife to older age and reduce the likelihood of developing cancer:
These results further emphasized the need to prevent chronic diseases support a healthy environment and promote a healthy lifestyle in the transition from midlife to the older age are the most important factors that can reduce substantially the risk of cancer.
Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.
The liquid is considered one of the healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.
To find a natural ingredient without side effects for the treatment of colon cancer, researchers at the Universiti Kebangsaan Malaysia, launched an investigation to examine the anti-tumor and anti-inflammation properties of crude ginger extract and Gelam honey against many types of cancer, including colorectal cancer.
The cells used in the experiment were divided into 4 groups: the first group represented HT29 cells without treatment, the second and third groups were cells treated singly with either ginger or Gelam honey, respectively, and the last group represented cells treated with ginger and Gelam honey combined.
Combined ginger and Gelam honey treatment stimulated the early cell death response by enhancing the function of proteins associated with programming cell death, namely, the caspase 9 and IκB genes, and inhibiting the function of proteins associated with cell proliferation.
The IC50 of ginger and Gelam honey alone were 5.2 mg/ml and 80 mg/ml, respectively also demonstrated similar efficacy as the IC50 of the combination treatment of 3 mg/ml of ginger plus 27 mg/ml of Gelam honey.
These results suggest ginger and Gelam honey used alone or in combination may be an effective chemopreventive and therapeutic strategy for inducing the death of colon cancer cells.
Further differentiation of the anti-proliferative effects of ginger and Gelam honey and their efficacy in enhancing the anti-cancer effects of 5-FU (5-fluorouracil) against a colorectal cancer cell line, HCT 116. researchers showed that
* Ginger (IC50 of 3mg/mL) is more potent than Gelam honey (IC50 of 75 mg/mL) in inhibiting the growth of HCT 116 cells.
* Combined treatment (35 mg/mL) of the two compounds (3mg/mL ginger+75 mg/mL Gelam honey) synergistically lowered the IC50 of Gelam, honey, to 22 mg/mL without reducing the inhibitory effect against colon cancer cell line.
* Gelam honey markedly enhanced 5-FU inhibiting effects on the growth of HCT 116 cells.
Subsequent analysis on the induction of cellular apoptosis also suggested the individual treatment of ginger and Gelam honey produced higher apoptosis compared to 5-FU alone.
These results once again suggested that Gelam honey and ginger extract used alone or in combination could potentially enhance the chemotherapeutic effect of 5-FU against colorectal cancer.
Taken altogether, honey used alone or combined with ginger might process significant and profound effects in reducing the risk of colon cancer and combined with primary therapy for the treatment of colon cancer.
However, further data collection large example size and multi-center studies performed with human consumption of whole food or its bioactive compounds during the disease will be necessary to complete the picture of honey anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells by Tahir AA1, Sani NF2, Murad NA3, Makpol S4, Ngah WZ5, Yusof YA. (PubMed)
(2) Gelam honey and ginger potentiate the anticancer effect of 5-FU against HCT 116 colorectal cancer cells by Hakim L1, Alias E, Makpol S, Ngah WZ, Morad NA, Yusof YA. (PubMed)
(3) Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells by Tahir AA1, Sani NF2, Murad NA3, Makpol S4, Ngah WZ5, Yusof YA. (PubMed)
(4) Age and Cancer Risk by A Potentially Modifiable Relationship
Mary C. White, ScD, Dawn M. Holman, MPH, Jennifer E. Boehm, MPH, Lucy A. Peipins, PhD, Melissa Grossman, MPH, and S. Jane Henley, MSPH. (PMC)
Scientists may have found a sweet functional food that processes the potential for the prevention and treatment of cancer, some studies suggested.
Cancers are a group of chronic diseases, caused by cell growth and uncontrollably in some specific tissues and organs.
Most primary cancers start in the cells on the surface of the inner lining of tissue caused by the alternation of DNA.
At the later stage, after penetrating deep into the tissue of the infected organs, most primary cancers can travel a distance away from the original site to damage other healthy tissue and organs.
As they grow large enough, they can also suppress the nearby tissue and nerve cells, causing severe pain and localized symptoms.
Researchers do not know the exact causes of colon cancer. Neither do they know why some people have the same health conditions, diet patterns ethnicity, and family history, some are susceptible to the early onset of the diseases, while many others are not.
The most common risk factors, epidemiologically are associated with the types of cancer. The National Cancer Institute suggested that aging, tobacco, long-term sun and radiation exposure, chemicals and other substances, some viruses and bacteria, certain hormones, family history of cancer, alcohol, poor diet, lack of physical activity, or being overweight are the common causes of cancer.
In the challenges, the idea that cancer cannot be prevented among older adults, researchers at the National Center for Chronic Disease Prevention and Health Promotion launched a study by examining different aspects of the relationship between age and cancer said, "Although the sequential patterns of aging cannot be changed, several age-related factors that contribute to disease risk can be".
What are the age-related factors that contribute to cancer changes? researchers continued. "For most adults, age is coincidentally associated with preventable chronic conditions, avoidable exposures, and modifiable risk behaviors that are causally associated with cancer", and "current evidence suggests that for most adults, cancer does not have to be an inevitable consequence of growing older. Interventions that support healthy environments, help people manage chronic conditions, and promote healthy behaviors may help people make a healthier transition from midlife to older age and reduce the likelihood of developing cancer:
These results further emphasized the need to prevent chronic diseases support a healthy environment and promote a healthy lifestyle in the transition from midlife to the older age are the most important factors that can reduce substantially the risk of cancer.
Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.
The liquid is considered one of the healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.
To find a natural ingredient without side effects for the treatment of colon cancer, researchers at the Universiti Kebangsaan Malaysia, launched an investigation to examine the anti-tumor and anti-inflammation properties of crude ginger extract and Gelam honey against many types of cancer, including colorectal cancer.
The cells used in the experiment were divided into 4 groups: the first group represented HT29 cells without treatment, the second and third groups were cells treated singly with either ginger or Gelam honey, respectively, and the last group represented cells treated with ginger and Gelam honey combined.
Combined ginger and Gelam honey treatment stimulated the early cell death response by enhancing the function of proteins associated with programming cell death, namely, the caspase 9 and IκB genes, and inhibiting the function of proteins associated with cell proliferation.
The IC50 of ginger and Gelam honey alone were 5.2 mg/ml and 80 mg/ml, respectively also demonstrated similar efficacy as the IC50 of the combination treatment of 3 mg/ml of ginger plus 27 mg/ml of Gelam honey.
These results suggest ginger and Gelam honey used alone or in combination may be an effective chemopreventive and therapeutic strategy for inducing the death of colon cancer cells.
Further differentiation of the anti-proliferative effects of ginger and Gelam honey and their efficacy in enhancing the anti-cancer effects of 5-FU (5-fluorouracil) against a colorectal cancer cell line, HCT 116. researchers showed that
* Ginger (IC50 of 3mg/mL) is more potent than Gelam honey (IC50 of 75 mg/mL) in inhibiting the growth of HCT 116 cells.
* Combined treatment (35 mg/mL) of the two compounds (3mg/mL ginger+75 mg/mL Gelam honey) synergistically lowered the IC50 of Gelam, honey, to 22 mg/mL without reducing the inhibitory effect against colon cancer cell line.
* Gelam honey markedly enhanced 5-FU inhibiting effects on the growth of HCT 116 cells.
Subsequent analysis on the induction of cellular apoptosis also suggested the individual treatment of ginger and Gelam honey produced higher apoptosis compared to 5-FU alone.
These results once again suggested that Gelam honey and ginger extract used alone or in combination could potentially enhance the chemotherapeutic effect of 5-FU against colorectal cancer.
Taken altogether, honey used alone or combined with ginger might process significant and profound effects in reducing the risk of colon cancer and combined with primary therapy for the treatment of colon cancer.
However, further data collection large example size and multi-center studies performed with human consumption of whole food or its bioactive compounds during the disease will be necessary to complete the picture of honey anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells by Tahir AA1, Sani NF2, Murad NA3, Makpol S4, Ngah WZ5, Yusof YA. (PubMed)
(2) Gelam honey and ginger potentiate the anticancer effect of 5-FU against HCT 116 colorectal cancer cells by Hakim L1, Alias E, Makpol S, Ngah WZ, Morad NA, Yusof YA. (PubMed)
(3) Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells by Tahir AA1, Sani NF2, Murad NA3, Makpol S4, Ngah WZ5, Yusof YA. (PubMed)
(4) Age and Cancer Risk by A Potentially Modifiable Relationship
Mary C. White, ScD, Dawn M. Holman, MPH, Jennifer E. Boehm, MPH, Lucy A. Peipins, PhD, Melissa Grossman, MPH, and S. Jane Henley, MSPH. (PMC)
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