#Sulforaphane Found in #Broccoli Slows the Progression of Hepatic Lipidosis Associated with #LiverDiseases, Researchers Show

Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing it to other parts of the body.

The liver also produces cholesterol, a waxy substance that aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Liver disease is a class of medical conditions characterized by reducing partly or completely the function of the liver, including liver failure.


A fatty liver is a liver condition associated with the accumulation of excess fat in the liver.

Non-alcoholic fatty liver (NAFL) is the early stage of nonalcoholic steatohepatitis (NASH) caused by the accumulation of fat in the liver, other than excessive use of alcohol.

Nonalcoholic steatohepatitis (NASH) is a type of inflammatory non-alcoholic fatty liver disease caused by excessive fat accumulated in the liver.

Nonalcoholic steatohepatitis (NASH) is asymptomatic until the condition is developed into cirrhosis, the condition that causes advanced liver scars, and reduces the performance of the liver.

In other words, if more than 5% – 10% percent of your liver’s weight is fat, you have a fatty liver (steatosis).
The prevalence rate of non-alcoholic fatty liver disease (NAFLD) among the more affluent regions of China, is approximately 15%. The number may decrease substantially if the poor rural populations where obesity is non-existence are also taken into account.

In the US, over 100 million people have non-alcoholic fatty liver disease and the condition has doubled over the past 20 years. Today, the disease is also prevalent in liver disease in children.

Most people at the early stage of NAFLD are asymptomatic. However, as the disease progresses into the later stage, most patients experience symptoms of right upper abdominal discomfort, fatigue, and/or malaise, and jaundice(20) with yellowing of the skin and eyes.

Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

To find a natural food for the prevention and treatment of liver diseases, researchers examined the effect of dietary broccoli protects against fatty liver development.

The study included male 15-day-old C57BL/6J mice that were given DEN and placed on a Western or Western+10% Broccoli diet from the age of 4 weeks through 7 months. before exposure to the hepatocarcinogen diethylnitrosamine (DEN).

According to the results of the analysis,* Dietary broccoli decreased hepatic triacylglycerols, NAFLD, liver damage, and tumor necrosis factor by month 5 without changing body weight or relative liver weight induced by hepatocarcinogen diethylnitrosamine (DEN).

* However, broccoli feeding did not have low liver carcinogenesis, observed in 100% of tested mice.

Based on the results, researchers wrote, " We conclude that broccoli, a good source of sulforaphane, slows the progression of hepatic lipidosis, but not tumourigenesis in this robust model".

Taken together, broccoli may be considered functional food for the prevention of fatty liver, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary broccoli protects against fatty liver development but not against progression of liver cancer in mice pretreated with diethylnitrosamine by Chen YJ1, Myracle AD1, Wallig MA2, Jeffery EH. (PubMed)

#Healthyfood #Onion Exhibits Anti-Hypertensive Property through Its Antioxidant Expression, According to Studies

Kyle J. Norton

Hypertension, a condition associated with the cluster of metabolic syndrome is a medical condition associated with abnormally high blood pressure.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood and changes constantly depending on activity. However, persistent hypertension due to poor management over time can lead to diabetes and cardiovascular disease.

According to the statistics provided by the American Heart Association., nearly half of all adults in the United States are living with high blood pressure, or 1 in 3 Americans are hypertensive.

Hypertension is a leading risk factor of heart disease and stroke that cause most death in the US

The most common prevalent factors associated with the condition onset are family history, aging, being male, being overweight or obese, ethnicity, physical inactivity, unhealthy diet, and medical conditions such as chronic kidney disease.


Believe it or not, excessive alcohol drinking is also one of the major causes besides obesity in elevating the syndrome onset.

Depending on the levels of blood pressure, most people with mild hypertension are asymptomatic. However, unmanaged high blood pressure can induce complications of heart attack or stroke, heart failure, weakened and narrowed blood vessels, metabolic syndrome, and trouble with memory or understanding,

In severe cases, chronic hypertension can lead to dementia.

Conventionally, blood pressure medications have been found to prevent many deaths from heart disease and stroke over the past 30 years, however, long-term intake of such medications has caused many side effects such as damaging the kidney.

Some researchers suggested by making lifestyle changes, maintaining an ideal weight and diet with low salt, you could do just fine without the drugs.

Dr. Myung Hwa Yang wrote, "healthy eating, weight management, and appropriate physical activity are essential for the management of high blood pressure in adults since these lifestyle management have the potential to improve blood pressure control and even reduce the need for medication.23)"

"Our findings indicate that to achieve better rates of blood pressure control, the clinician should advise lifestyle modifications such as adequate physical activity and low salt intake, in addition to prescribing medication and monitoring the patient for hypertension control".

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.


Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.

In finding a potent ingredient that processes cardioprotection researchers examined the effects of onion on blood pressure in N(G)-nitro-L-arginine methyl ester (L-NAME) induced-hypertensive rats and stroke-prone spontaneously hypertensive rats (SHRSP).

The vivo study included male 6-weeks-old Sprague-Dawley rats induced-hypertensive to receive tap water containing L-NAME of a concentration of 50 mg/kg BW/day and dried onion at 5%.

Onion application showed significant anti-hypertensive activity on the L-NAME induced-hypertensive rats and the SHRSP by decreasing the thiobarbituric acid reactive substances (TBARS) associated with lipid peroxidation in blood plasma.

Furthermore, nitrate/nitrite (products of nitric oxide (NO)) involved in blood vessel relaxation excreted in urine and the NO synthase (NOS) associated with vascular tone activity in the kidneys in SHRSP were also increased by the onion injection.

Interestingly, the efficacy of onion that inhibits the onset of high blood pressure was not found similar to those in the L-NAME-induced hypertensive rats such as increasing the levels of NOS.


More precisely, onion promoted hypotension in L-NAME treated rats without inhibiting of NOS activity by L-NAME, and decreased nitrate/nitrite excretion in urine may be associated with only the promotion of antioxidant activity

Dr. Sakai Y, the lead scientist said, "The mechanism of the antihypertensive effect of onion probably involves the increased saving of NO by the antioxidative activity of onion in L-NAME induced-hypertensive rats".


Taken together, onion may be considered a remedy for the prevention and treatment of hypertension, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antihypertensive effects of onion on NO synthase inhibitor-induced hypertensiverats and spontaneously hypertensive rats by Sakai Y1, Murakami T, Yamamoto Y. (PubMed)
(2) Effects of boiling on the antihypertensive and antioxidant activities of onion by Kawamoto E1, Sakai Y, Okamura Y, Yamamoto Y. (PubMed)
(3) The Effect of Lifestyle Changes on Blood Pressure Control among Hypertensive Patients by Myung Hwa Yang,1 Seo Young Kang,1 Jung Ah Lee,1 Young Sik Kim,1 Eun Ju Sung,2Ka-Young Lee,3 Jun-Su Kim,3 Han Jin Oh,4 Hee Chul Kang,5 and Sang Yeoup Lee. (PMC)

#Cucumber's #Cucurbitacin B (CuB) Protects Gut Microbiota by Suppressing LPS-Induced Production of Pro-Inflammatory Cytokines

Kyle J. Norton

Gut Microbiota is a community of microorganisms living in our gut. Under normal conditions, the ratio of the gut microbiome composition is balanced.

However, the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle may alternate the ratio by increasing the growth of "bad" bacteria, leading to the development of chronic diseases such as inflammatory bowel disease, obesity, cancer, and autism.

In other words, an imbalance of the gut microbiota may have a strong and negative impact on immunity, digestive, fat, and carbohydrate metabolism, and the central nervous system

* In immunity, the balance of the gut microbes is shown to stimulate the immune function against inflammatory immune disorders.

* In the digestive system, balanced gut microbes protect the gut against gastrointestinal diseases and non-gastrointestinal diseases. caused by overexpression of bad bacteria.

* In carbohydrate metabolism, gut microbes influence the nutrient extraction from the diet, thus reducing the risk of obesity and obesity complications.

* Neurologically, gut microbiota can control brain insulin signaling and metabolite levels that play a critical role in neurobehaviors.

Out of many prevalent factors that cause the onset of the unbalanced ratio of gut microbiota, some researchers suggested that the Western diet may have negatively influenced the overgrowth of bad microorganisms in the gut.

Dr. Marit K. Zinöcker, the lead scientist wrote, "Western diet promotes inflammation that arises from both structural and behavioral changes in the resident microbiome"

And, "The environment created in the gut by ultra-processed foods, a hallmark of the Western diet, is an evolutionarily unique selection ground for microbes that can promote diverse forms of inflammatory disease".


The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.

To find a natural compound that enhances the gut microbiome composition, researchers compared the effects of carrot, cucumber, and broccoli seed flour extracts with 50% acetone on gut microbiota modulating capacity.

In vitro, all three seed flour extracts enhanced the total number of gut bacteria and altered the abundance of specific bacterial phylum or genera.


In other words, cucumber showed a potential effect to improve the ratio of gut microbiota in the flavor of the "good" bacteria, similar to those of carrot and broccoli.


In J774A.1 cells, cucumber also exerted a similar activity by protecting the microbiota that exhibits anti-inflammatory activity by suppressing LPS-induced production of pro-inflammatory cytokines, such as IL-1β and COX-2 mRNA expressions.

Furthermore, in obesity-induced progression of metabolic disorders, especially type 2 diabetes (T2DM), cucumber not only improved IR in obese mice and relieved inflammation in adipose tissue and blood but also enhanced the microbiota composition ratios.


More precisely, cucumber improved the ratio of gut microbiome composition by promoting IR and reducing inflammation.

Taken together, cucumber may be used for the improvement of gut microbiota, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Chemical Compositions of Cold-Pressed Broccoli, Carrot, and Cucumber Seed Flours and Their in Vitro Gut Microbiota Modulatory, Anti-inflammatory, and Free Radical Scavenging Properties by Choe U1, Li Y1,2, Gao B2, Yu L1, Wang TTY, Sun J, Chen P, Liu J3, Yu L. (PubMed)
(2) Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the GutMicrobiome in Lepob/Lepob Mice by Lee D1, Yoo JH1, Lee BC. (PubMed)
(3) The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease by Marit K. Zinöcker1,* and Inge A. Lindseth. (PMC)

#Lycopene Inhibits Parameters that Cause the #KidneyDisease, Researchers Show

Kyle J. Norton

The kidneys are a pair of kidney-shaped organs located on either side of your spine with a function to filter out the wastes from the blood before passing the wastes through urinary secretion.
Besides being accompanied by the liver and skin to form a detox system in the body, the kidneys also process significant effects that maintain the body's fluid balance and regulate the production of red blood cells and high blood pressure.

Kidney damage can be acute such as an overdose of toxin or chronic. Acute kidney diseases can be cured if the underlying cause is found.

Chronic kidney disease (CKD) is a slow and progressive disease that can lead to kidney failure over time.

CKD can cause dangerous levels of fluid, electrolytes, and wastes to build up in the body.

According to statistics, approximately 14 percent of the US general population suffers from CKD. More than 661,000 Americans are living with kidney failure, inclduing 468,000 individuals on dialysis.

People with reduced kidney function do not experience any symptoms until the advanced stage. In other words, kidney disease in the advanced stage can lead to dangerous levels of fluid, electrolytes, and building toxins in the body.

Out of many risk factors associated with CKD, some researchers suggest high blood pressure is one most prevalent factors found in most patients.

In this advanced stage, patients also experience symptoms of gastrointestinal discomfort, weakness,
sleep problems, changes in urination, decreased mental sharpness, muscle twitches and cramps, and swelling of feet and ankles, particularly persistent itching.


Some researchers suggest high blood pressure is one of the major causes of CKD.

The Natural Kidney Foundation wrote, "More than half the people with chronic kidney disease (CKD) have high blood pressure. High blood pressure increases the chance that kidney disease will get worse"

And "Following your treatment plan carefully and keeping your blood pressure under control can help to prevent these complications".

Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potent ingredient for the protection of kidney damage, researchers examined the effect of lycopene on the nephrotoxicity of deltamethrin.

The study included male albino rats that were divided into four groups with animals each: group I served as control, which received a standard diet; Group II received oral administration of deltamethrin (1.28 mg/kg per day) for 30 days; group III received both deltamethrin and lycopene (1 mg/kg per day); group IV received lycopene (1 mg/kg per day).

According to the results at the end of the experiment, deltamethrin treated group not only showed significantly increased expression of the pro-inflammatory cytokine, TNF-α but also caused mild necrotic changes of the kidney associated with localized cell death due to interruption of the blood supply.

Renal proximal tubules in the deltamethrin-treated group also showed an increased number and irregular shape of mitochondria causing the reduced function of the cell in the kidney to take nutrients from the cell break it down and turn it into energy.

Vacuolar degeneration in the epithelial cells, increased number of lysosomes, and loss of apical microvilli associated with the reduced function of kidney cells in the absorptive and secretory function may lead to the decrease of the detoxed function of the kidney.

Moreover, focal segmental thickening and the duplication of the glomerular basement membrane and podocyte changes are involved in kidney damage. were also found in the deltamethrin-treated group.

Pretreatment of lycopene demonstrated a strong effect either restoring the kidney tissue damage or inhibiting the parameters that cause the kidney disease.


Based on the findings, researchers said, "Histopathological and ultrastructural study showed some protective effect of lycopene on kidney tissues".

Taken together, lycopene found in tomatoes may be considered a supplement for the prevention and treatment of kidney damage, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Aflatoxin B1 induced renal and cardiac damage in rats: Protective effect of lycopene by Yilmaz S1, Kaya E2, Karaca A2, Karatas O. (PubMed)
(2) Protective effect of lycopene on deltamethrin-induced histological and ultrastructural changes in kidney tissue of rats by El-Gerbed MS. (PubMed)
(3) High Blood Pressure & Kidney Disease. What is high blood pressure? the Natural Kidney Foundation. (NIH)

Garlic-Age-#Extract and Its #Allicin Exert a Strong Endogenous Antioxidant Defenses in Hippocampus Associated with #Cognitive Impaire, Researchers Suggest

Kyle J. Norton

Allicin, a bioactive and organosulfur compound may have a profound effect in improving the cognitive function of the elderly, some scientists suggested.

Cognitive activity is a long-term process of reasoning, memory, attention, and language and information accumulated that leads to knowledge.

In the elderly, the causes of cognitive dysfunction are associated with a set of factors, including medication side effects, metabolic and/or endocrine derangements due to aging, delirium due to intercurrent illness, depression, and dementia.

Dr. Ian M. Deutchki, MD University of Rochester, in the article What’s causing my older patient’s cognitive decline? wrote, "n primary care settings, when patients complain of memory loss, there is a 20% to 30% chance they will be found to have a mild cognitive impairment (MCI) or some level of dementia" and "Remote memory, semantic memory (factual information), and procedural memory (knowledge of skills and procedures) tend to remain intact with aging.4 Short-term memory (simple maintenance of information over a short period) shows little change with aging. However, working memory, which requires the manipulation of in decline".

Some researchers suggested besides the correlated factors of aging in the risk of cognitive decline, a healthy diet, and lifestyle accompanied by physical inactivity are also some of the risk factors that have a significant effect on the contribution of cognitive decline.

Dr. P.J. Smith, the lead author at the Duke University Medical Center, in the concerns of cognitive decline, an increasingly important public health problem, with more than 100 million adults worldwide associated with a change of lifestyle said, "Lifestyle factors including dietary patterns, may be important in the prevention of cognitive decline and dementia in later life" and "antioxidants, fatty acids, and B vitamins are associated with better cognitive functioning"

This conclusion suggested that following a healthy diet pattern, lifestyle and moderate exercise before the onset of the syndrome is one of the best methods in the prevention of neurodegenerative diseases in later life.

In elderly with cognitive decline, Dr. María Alicia Camina suggested malnutrition is a highly prevalent geriatric syndrome in the elderly with dementia, especially in institutionalized patients and in subjects in advanced stages of the illness.

Therefore by changing the pattern of diet that targets malnutrition in the elderly, through nutritional screening and a complete nutritional assessment, the progression of cognitive decline in the elderly can be slowed down.

Allicin is a phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in onion and garlic.

Dr. Li XH, the lead scientist in the research program at the Medicine of Jishou University in reaffirming the effect of allicin on the learning and memory abilities in the course of normal aging cognitive abilities associated with the Nrf2 expression in the decline with aging launched an investigation to assess the effects of allicin on endogenous antioxidant defenses in hippocampus of a cognitively impaired aged mouse.


The organosulfur compounds, allicin activated Nrf2 during the application process by donating an electron pair to an electrophile to form a chemical bond in relation to a reaction through its electrophil·ic effect.

Treatment of allicin significantly through the expression of Nrf2 antioxidant signaling pathways ameliorated aging-induced cognitive dysfunction in the tested aged mouse.

The Nrf2 antioxidant signaling pathways are master mediators of antioxidant and detoxification responses and regulators of the cellular redox state that protect us from pathologies that are caused or exacerbated by oxidative stress in the induction of aging-related diseases, including cognitive decline.

Furthermore, antioxidant also plays an important role in metabolic regulation and their interaction with central signaling systems that respond to nutritional inputs. These results have a strong impact on the theory associated with malnutritional effects that cause the onset of neurodegenerative diseases including Alzheimer's disease in the elderly.

In the final report of the experiment, the researchers wrote, "Allicin could be recommended as a possible candidate for the prevention and therapy of cognitive deficits in aging and Alzheimer's disease".

In the further differentiation of the oxidative modification of DNA, proteins, and lipids associated with reactive oxygen species (ROS) in the initiation of aging and disease, including cardiovascular, neurodegenerative and inflammatory diseases and cancer, researchers showed
* Extracts of aged garlic extract (AGE) contain antioxidant phytochemical allicin exerts a protective activity against oxidant damage.

* Up to 20 months of garlic-aged extract, creates antioxidant properties that inhibit the unstable free radicals with antioxidant activity, such as allicin, that lead to stable and highly bioavailable water-soluble organosulfur compounds.

* Allicin and other compounds found in AGE inhibited the overexpression of ROS by enhancing the cellular antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase, and increasing glutathione in the cells.


* The chemical ingredients of the AGE also inhibit lipid peroxidation by reducing ischemia/reperfusion damage and inhibiting oxidative modification of LDL, thus protecting endothelial cells from injury by the oxidized molecules, which contributes to atherosclerosis.

More importantly, Allicin and compounds in the AGE showed the ability to protect against oxidant-induced disease, acute damage from aging, radiation and chemical exposure, and long-term toxic damage.

Taken together, Allicin, the major bioactive compound found in garlic and onion may be considered a functional supplement for the prevention of cognitive decline and an adjunct therapy with conventional medicine to delay the progression of neurodegenerative diseases in the elderly.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Cognition (Wikipedia)
(2) Allicin ameliorates cognitive deficits aging-induced learning and memory deficits through enhancing Nrf2 antioxidant signaling pathways by Li XH, Li CY, Lu JM, Tian RB, Wei J.(PubMed)
(3) Antioxidant health effects of aged garlic extract by Borek C.(PubMed)
(4) What’s causing my older patient’s cognitive decline? by Dr. Ian M. Deutchki, MD University of Rochester,(the Journal of Family Practice)
(5) Dietary Factors and Cognitive Decline by P.J. Smith and J.A. Blumenthal. (PMC)
(6) Diet and Nutrition in Dementia and Cognitive Decline by Dr. María Alicia Camina

#Herbal #Turmeric Modulate the Phase II Detoxification Enzymes Associated with Skin Regeneration and Wound Healing

Kyle J. Norton

Skin is a large organ that protects our internal organs and tissues by shielding them from the invasion of foreign pathogens. Several different components, such as water, protein, lipids, and different minerals and chemicals have been found to make up the skin integrity.
Furthermore, the skin accompanied by the liver and kidney forms a detoxed triad by eliminating toxins from the body.

Skin regeneration or repair is a natural process which epithelial cells restore the epidermis once the dermis has been regenerated.

However, in major injuries, the repair mechanisms may not completely restore the skin to its original condition, leading to the formation of scars.

In details, the skin regenerates through 3 stages
* Initial phase or acute phase of infection.
The immune system's white blood cells of the first line of defense stimulate the blood platelets to cover the wound or injury and production of proinflammatory cytokines, leading to the creation of new blood vessels to replace those that were damaged in the precipitating incident.

* Regeneration of the epidermis and dermis involved in the proliferation of the cells of the stratum basale and the movement of a healthy portion of the dermis at the edges of the wound into its interior.

Any disruption of the process of skin regeneration can lead to the formation of scars


Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In finding a potential compound for the treatment of skin wounds, researchers examined the effect of curcumin the main constituent found in turmeric on free radical scavenging and anti-inflammation activity.

During the experiment, curcumin was found to modulate the phase II detoxification enzymes associated with detoxification reactions and the protection against oxidative stress.


Furthermore, the injection of curcumin also enhanced skin regeneration and wound healing.

Moreover, curcumin protects the skin by quenching free radicals and reducing inflammation involved in protein that stimulates the production of inflammatory cytokines.

Curcumin administration also promotes skin regeneration in wound healing by improving wound-healing time, collagen deposition, and increased fibroblast and vascular density in wounds.

Additionally, the effects of skin regeneration and wound healing were also attributed to the compound's proangiogenic property.

Based on the findings, researchers said, "These studies suggest the beneficial effects of curcumin and the potential of this compound to be developed as a potent nontoxic agent for treating skin diseases".


Taken altogether, turmeric processed with a high amount of curcumin may be considered a supplement for the enhancement of skin regeneration in wound healing, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Skin regenerative potentials of curcumin by Thangapazham RL1, Sharad S, Maheshwari RK. (PubMed)
(2) Beneficial role of curcumin in skin diseases by Thangapazham RL1, Sharma A, Maheshwari RK. (PubMed)

#Phytochemical #AnacardicAcid Processes Anti Breast Cancer Activity, Researchers Say

Kyle J. Norton

Anacardic acids, a phytochemical found abundantly in the may process a potential effect in reducing the risk and treatment of breast cancer, some scientists suggested.
Breast cancer is a chronic condition associated with irregular cell growth caused by the alternation of DNA of breast cells.

Most cases of breast cancer start on the cells on the surface of the inner lining tissue of the milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

However, after colonizing most of the breast tissue, the cancer cell at a later stage can travel a distance away to infect other healthy tissue and organs through the circulation of lymph and blood.

According to the statistics, every year, 75,000 and 234,000 patients are diagnosed with breast cancer (BC) in Germany and in the USA, respectively.

In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Although genetic preposition such as mutated genes BRCA 1 and 2 are the best-known risk factors associated with the 60% increased risk of breast cancer.

An unhealthy lifestyle including poor diet and physical inactivity is also the most mentioned risk factor by scientists.

Dr. Max Dieterich, the lead scientist in the study "Influence of Lifestyle Factors on Breast Cancer Risk" wrote, "Epidemiological studies that lifestyle factors play an important role in the development of BC. For example, daughters of Asian women who have migrated to the USA revealed an increased risk of developing BC, which was attributed to the exposure to a different lifestyle and nutritional factors".

These results suggested regardless of ethical origin, if you follow the Western diet and lifestyle, you are at higher levels of risk, compared to those who follow the traditional diet.

More precisely, if you are following a diet high in saturated and trans fat, red meat, and processed food, regardless of where you're from, you are at a higher risk of breast cancer.

Therefore modifying the lifestyle risk factors to develop a strategy for BC prevention is an urgency for the prevention of breast cancer.

Other risk factors associated with breast cancer are age, family history of BC, personal breast history (pre-malignant lesions), breast density, thorax radiation, and several menstrual cycles during the lifetime.

To understand the effect of Anacardic acid (AnAc; 2-hydroxy-6-alkylbenzoic acid), a dietary and medicinal phytochemical anticancer activity in cell and animal models, researchers at the cancer team program at the University of Louisville School of Medicine, conducted an experiment to test the mechanisms of the AnAc in the inhibition of breast cancer cell proliferation.


Application of the AnAc 24:1(omega5) purified from geranium (Pelargonium x hortorum) inhibited the proliferation of estrogen receptor alpha (ERalpha)-positive MCF-7 and endocrine-resistant LCC9 and LY2 breast cancer cells with greater efficacy than ERalpha-negative primary human breast epithelial cells, MCF-10A normal breast epithelial cells, and MDA-MB-231 basal-like breast cancer cells.

AnAc 24:1(omega5) inhibited cell cycle progression and induced apoptosis in a cell-specific manner.


AnAc 24:1(omega5) inhibited the breast cancer cell line and was attributed to the stimulation of proteins that are responsible for program cell death and anti-cell proliferation.

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Dr. Schultz DJ, the lead scientist at the end of the study said, "These data indicate that AnAc 24:1(omega5) inhibits cell proliferation, cell cycle progression, and apoptosis in an ER-dependent manner by reducing ER-DNA interaction and inhibiting ER-mediated transcriptional responses".

Furthermore, in examining the series of N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-alkyl (and alkenyl) benzamides related to the anacardic acid derivative CTPB prepared from 2,6-dihydroxybenzoic acid, researchers found that In U937 cells
* Derivatives labeled 7 c, 7 d, 7, and 7 j exerted a potential effect in inducing cell-cycle arrest in the G1 phase,

* The derivative also causes apoptosis in about 20 % of the cells and increases the acetylation of H3. Loss of acylation levels of H3 was associated with patients with breast cancer.


Taken together, Anacardic acids may be considered a functional phytochemical for the prevention and an adjunct therapy combined with the primary medicine for the treatment of breast cancer.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anacardic acid inhibits estrogen receptor alpha-DNA binding and reduces target gene transcription and breast cancer cell proliferation by Schultz DJ, Wickramasinghe NS, Ivanova MM, Isaacs SM, Dougherty SM, Imbert-Fernandez Y, Cunningham AR, Chen C, Klinge CM. (PubMed)
(2) New anacardic acid-inspired benzamides: histone lysine acetyltransferase activators.
Souto JA, Benedetti R, Otto K, Miceli M, Alvarez R, Altucci L, de Lera AR.(PubMed)