Kyle J. Norotn
Insulin sensitivity is a term to measure how sensitive the body's cells are in response to insulin.
Low insulin sensitivity, also known as insulin resistance induces high levels of glucose in the blood. Over the long term insulin resistance ultimately can lead to type II diabetes.
Insulin resistance is considered a hallmark of type II diabetes and a condition in the cluster of metabolic syndrome.
There is no single cause of insulin resistance. Medical conditions, being extremely overweight, ethnicity, genetic proposition, and physical inactivity are some of the prevalent risks of insulin resistance.
Some researchers suggested that widespread obesity over the past few decades in the induction of insulin resistance at the alarming rate may be correlated to the promotion of a high-fat diet in the Western world.
Dr. von Frankenberg AD, the lead scientist wrote, "The rate of glucose disposal (Rd) during low- and high-dose insulin decreased on the HFD but remained unchanged on the LFD" and "Changes in subcutaneous fat were positively associated with changes in insulin sensitivity on the LFD (r = 0.78, p <0.01) with a trend on the HFD".
And, "A diet very high in fat and saturated fat adversely affects insulin sensitivity and thereby might contribute to the development of type 2 diabetes".
In other words, if you are a high-fat diet follower, you are at substantial risk to develop insulin resistance.
Tomato is a red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound or whole food for the improvement of insulin sensitivity, researchers examined lycopene, one of the major carotenoids in tomatoes, and other whole foods in high-fat diet (HFD)-animal models.
Mice selected for the study were fed with different doses of dry tomato peel (DTP) in a high-saturated-fat (HSF) diet and cholesterol-rich diet-induced oxidative stress for the 12-weeks.
Lycopene significantly prevented HFD-induced increase of fasting blood glucose and insulin level and insulin intolerance and a decrease of hepatic glycogen content associated with the production of hepatic insulin.
Furthermore, increased levels of pro-inflammatory cytokines and CRP levels in mice fed HFD involved in the risk of insulin intolerance were also reduced significantly by the presence of lycopene
Moreover, lycopene was also found to suppress the increase of the expression of protein Srebp-1c, which regulates the glucose and the cluster of conditions of metabolic syndrome in mice fed HFD.
Interestingly, lycopene promoted insulin sensitivity by inducing the STAT3 signaling in reducing fasting blood glucose and insulin level.
In other words, lycopene exerted a strong insulin sensitivity by inhibiting inflammation, insulin resistance, and metabolic dysfunction.
In order to reveal more information about the tomato in the promotion of insulin sensitivity, researchers investigated the effects of different doses of dry tomato peel (DTP) on the levels of oxidative stress in mice fed an HSF and cholesterol-rich diet for 12 weeks.
The study included BALB/c male mice (n=40) (8 weeks old, weighing 22.2±1.0 g) divided into four treatment groups (10 mice/group): (a) high-fat control diet (HF Ctrl), which contains sunflower oil as a sole source of fat; (b) HSF/high-cholesterol (HC) diet; (c) HSF/HC diet supplemented with 9% DTP and (d) HSF/HC diet supplemented with 17% DTP.
According to the observation of the tested assays, HSF/HC diet mice significantly increased adipose tissue weight, fasting plasma glucose, fasting plasma insulin, and lipid peroxidation.
Administration of lycopene DTP increased plasma lycopene concentration and reduced the development of indicators of metabolic syndrome, with no consistent effect of the DTP dose.
Dr. Zidani S, the lead scientists after taking into account co and confounders said, "Among mice fed the HSF/HC diet, DTP supplementation appears to have a beneficial effect on insulin resistance, which confirms the antiatherogenic effect of DTP".
Taken altogether, tomatoes processed high amounts of bioactive compound lycopene may be considered supplements for the prevention and treatment of insulin intolerance, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene Improves Insulin Sensitivity through Inhibition of STAT3/Srebp-1c-Mediated Lipid Accumulation and Inflammation in Mice fed a High-Fat Diet by Zeng Z1, He W2, Jia Z2, Hao S. (PubMed)
(2) Effect of dry tomato peel supplementation on glucose tolerance, insulin resistance, and hepatic markers in mice fed high-saturated-fat/high-cholesterol diets by Zidane S1, Benakmoum A2, Ammouche A3, Benali Y4, Bouhadef A4, Abbeddou S. (PubMed)
(3) A high-fat, high-saturated fat diet decreases insulin sensitivity without changing intra-abdominal fat in weight-stable overweight and obese adults by von Frankenberg AD1,2,3, Marina A4, Song X5,6, Callahan HS7, Kratz M4,5,6, Utzschneider KM. (PubMed)
Saturday 2 September 2023
#Cruciferousvegetables Inhibits Genetic Pathways and #Mechanisms Associated with the Risk #NeurodegenerativeDiseases, Researchers Say
Kyle J. Norton
Neuroprotection is a process to preserve the neuronal structure and/or function against the death or gradual death of neurons, including the use of medicines and herbs.
In other words, neuroprotection protects the neuronal integrity against the reduction in the rate of neuronal loss over time inducing neurological disease, including neurodegenerative disease.
Neurological diseases are the medical conditions of brain disorders. Anything that involves structural, biochemical, or electrical abnormalities in the brain, spinal cord, or other nerves, including brain damage is considered neuron disease.
Neurodegenerative disease is the class of conditions associated with the progressive loss of neurons that occurs mostly in older adults, including dementia. The most common dementia in the US is Alzheimer`s disease (AD).
Alzheimer's disease is an irreversible, progressive brain disorder caused by the slow loss of neuron in the brain that affects the memory and thinking skills and, eventually, the ability to carry out the simplest tasks as the disease progress into the advanced stage.
According to the statistics, dementia affects over 47.5 million people worldwide, approximately 58 percent are living in low and middle-income countries.
Believe it or not, 5.8 million Americans of all ages are living with Alzheimer's dementia in 2019, and two-thirds of people with Alzheimer's disease are women.
Conventionally, as of today, there is no cure for dementia. Treatment of dementia is focusing improving dementia symptoms and slowing down the progression of the disease.
Cruciferous vegetables are a group of vegetables, belongings of the family Brassicaceae (also called Cruciferae) with many genera, and species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.
In finding a potential compound for the treatment of neurological diseases, researchers examined cruciferous vegetable neuroprotective activity.
According to the dietary information,
* SFN, a potent bioactive compound found in the veggies upregulated the nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant response element (ARE) genetic pathway by increasing the antioxidant enzymes produced by the host.
* SFN was found to protect the nervous system from many diseases and toxins in a few small human trials.
* Furthermore, according to the preclinical data, SFN protects the nervous system through multiple mechanisms and reduces the risk of many diseases and the burden of symptoms in existing conditions.
In other words, SFN processed protective effects in a multitude of neurological diseases and toxin exposures.
Based on the evidence, researchers said, "SFN is a promising neuroprotective phytochemical which needs further human trials to evaluate its efficacy in preventing and decreasing the burden of many neurological diseases".
Taken altogether, cruciferous vegetables may be considered neuroprotective functional foods, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The neuroprotective mechanisms and effects of sulforaphane by Klomparens EA1, Ding Y. (PubMed)
Neuroprotection is a process to preserve the neuronal structure and/or function against the death or gradual death of neurons, including the use of medicines and herbs.
In other words, neuroprotection protects the neuronal integrity against the reduction in the rate of neuronal loss over time inducing neurological disease, including neurodegenerative disease.
Neurological diseases are the medical conditions of brain disorders. Anything that involves structural, biochemical, or electrical abnormalities in the brain, spinal cord, or other nerves, including brain damage is considered neuron disease.
Neurodegenerative disease is the class of conditions associated with the progressive loss of neurons that occurs mostly in older adults, including dementia. The most common dementia in the US is Alzheimer`s disease (AD).
Alzheimer's disease is an irreversible, progressive brain disorder caused by the slow loss of neuron in the brain that affects the memory and thinking skills and, eventually, the ability to carry out the simplest tasks as the disease progress into the advanced stage.
According to the statistics, dementia affects over 47.5 million people worldwide, approximately 58 percent are living in low and middle-income countries.
Believe it or not, 5.8 million Americans of all ages are living with Alzheimer's dementia in 2019, and two-thirds of people with Alzheimer's disease are women.
Conventionally, as of today, there is no cure for dementia. Treatment of dementia is focusing improving dementia symptoms and slowing down the progression of the disease.
Cruciferous vegetables are a group of vegetables, belongings of the family Brassicaceae (also called Cruciferae) with many genera, and species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.
In finding a potential compound for the treatment of neurological diseases, researchers examined cruciferous vegetable neuroprotective activity.
According to the dietary information,
* SFN, a potent bioactive compound found in the veggies upregulated the nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant response element (ARE) genetic pathway by increasing the antioxidant enzymes produced by the host.
* SFN was found to protect the nervous system from many diseases and toxins in a few small human trials.
* Furthermore, according to the preclinical data, SFN protects the nervous system through multiple mechanisms and reduces the risk of many diseases and the burden of symptoms in existing conditions.
In other words, SFN processed protective effects in a multitude of neurological diseases and toxin exposures.
Based on the evidence, researchers said, "SFN is a promising neuroprotective phytochemical which needs further human trials to evaluate its efficacy in preventing and decreasing the burden of many neurological diseases".
Taken altogether, cruciferous vegetables may be considered neuroprotective functional foods, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The neuroprotective mechanisms and effects of sulforaphane by Klomparens EA1, Ding Y. (PubMed)
#Alliin Inhibits Receptor Associated with the Facilitating Cancer Cell Growth and Proliferation, Reserachers Suggest
Kyle J. Norton
Colorectal cancer is a medical condition caused by irregular cell growth that begins at the inner lining of the colon or rectum.
Most cases of colorectal cancers are diagnosed at the later stage due to the tendency of the slow-growing in nature. According to the statistics, only about 39% of patients are diagnosed at an early stage.
Some patients with polyps may not experience colon cancer 20 years later as the gradually enlarging polyps eventually penetrate the bowel wall.
At the advanced stage, primary colon cancer is found to induce secondary metastasis in the liver, lungs, brain, and peritoneum through blood and fluid circulation.
According to the statistics provided by the American Cancer Society, in 2019, approximately,
101,420 new cases of colon cancer and 44,180 new cases of rectal cancer will be diagnosed in the US. Colorectal cancer also will cause the death of 51,020 Americans.
The lifetime risk of developing colorectal cancer is1 in 22 (4.49%) for men compared to 1 in 24 (4.15%) for women.
The 5-year survival rate of colorectal cancer diagnosed at the localized stage is 90%. However, if cancer has spread to surrounding tissues or organs or the regional lymph nodes, the 5-year survival rate is 71%.
Out of many factors associated with colorectal cancer risk, some researchers suggested that the prevalence of obesity associated with the promotion of a high-fat diet may be the major culprit that causes the rise of colon cancer in the US.
Dr. O'Neill AM, the lead scientist said, "The increasing worldwide incidence of colon cancer has been linked to the spread of the Western lifestyle and in particular consumption of a high-fat Western diet. In this study, our objectives were to establish mouse models to examine the effects of high-fat Western diet-induced obesity on the growth of human colon cancer tumor xenografts, and to examine potential mechanisms driving obesity-linked human colon cancer tumor growth".
And, "human colon cancer growth is accelerated in animals that are obese and insulin-resistant due to the consumption of an HFWD".
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
In the urgency to find a natural compound for the treatment of colorectal cancer, researchers examined the anti-cancer activity of s-allyl-l-cysteine-sulfoxide (SACS)/alliin.
According to the tested assays, SACS showed a higher affinity towards the epidermal growth factor receptor (EGFR).
In other words, SACS inhibited the epidermal growth factor receptor (EGFR). associated with facilitating cancer cell growth and proliferation.
In order to reveal more information about alliin colonic protective effects, researchers compared the protective efficiency of three garlic powders with increased levels of alliin, obtained from bulbs grown in soils with different levels of sulfur fertilization, against DNA damage.
According to the comet assay, garlic powders were administered to rats for 2 weeks (5% of the diet), DNA damage induced by 1,2-dimethylhydrazine in the colon were also decreased strongly by the three garlic powders.
Interestingly, these decreases were not correlated to the allicin content of the garlic powders.
These results suggested that all compounds in the garlic including alliin worked synergistically to promote the efficacy of the whole food.
Sadly, feeding garlic powders protected the colon cells against DNA damage but did not modify the genotoxic activity of the direct-acting carcinogen methyl nitrosourea in the colon.
Taken altogether, alliin may be considered supplement for the prevention and treatment of colorectal cancer with no side effects, responding to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) EGFR gene regulation in colorectal cancer cells by garlic phytocompounds with special emphasis on S-Allyl-L-Cysteine Sulfoxide by Roy N1, Nazeem PA2, Babu TD3, Abida PS2, Narayanankutty A3, Valsalan R2, Valsala PA2, Raghavamenon AC. (PubMed)
(2) Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content by Singh V1, Belloir C, Siess MH, Le Bon AM. (PubMed)
(3) High-fat Western diet-induced obesity contributes to increased tumor growth in mouse models of human colon cancer by O'Neill AM1, Burrington CM2, Gillaspie EA3, Lynch DT2, Horsman MJ2, Greene MW. (PubMed)
Colorectal cancer is a medical condition caused by irregular cell growth that begins at the inner lining of the colon or rectum.
Most cases of colorectal cancers are diagnosed at the later stage due to the tendency of the slow-growing in nature. According to the statistics, only about 39% of patients are diagnosed at an early stage.
Some patients with polyps may not experience colon cancer 20 years later as the gradually enlarging polyps eventually penetrate the bowel wall.
At the advanced stage, primary colon cancer is found to induce secondary metastasis in the liver, lungs, brain, and peritoneum through blood and fluid circulation.
According to the statistics provided by the American Cancer Society, in 2019, approximately,
101,420 new cases of colon cancer and 44,180 new cases of rectal cancer will be diagnosed in the US. Colorectal cancer also will cause the death of 51,020 Americans.
The lifetime risk of developing colorectal cancer is1 in 22 (4.49%) for men compared to 1 in 24 (4.15%) for women.
The 5-year survival rate of colorectal cancer diagnosed at the localized stage is 90%. However, if cancer has spread to surrounding tissues or organs or the regional lymph nodes, the 5-year survival rate is 71%.
Out of many factors associated with colorectal cancer risk, some researchers suggested that the prevalence of obesity associated with the promotion of a high-fat diet may be the major culprit that causes the rise of colon cancer in the US.
Dr. O'Neill AM, the lead scientist said, "The increasing worldwide incidence of colon cancer has been linked to the spread of the Western lifestyle and in particular consumption of a high-fat Western diet. In this study, our objectives were to establish mouse models to examine the effects of high-fat Western diet-induced obesity on the growth of human colon cancer tumor xenografts, and to examine potential mechanisms driving obesity-linked human colon cancer tumor growth".
And, "human colon cancer growth is accelerated in animals that are obese and insulin-resistant due to the consumption of an HFWD".
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
In the urgency to find a natural compound for the treatment of colorectal cancer, researchers examined the anti-cancer activity of s-allyl-l-cysteine-sulfoxide (SACS)/alliin.
According to the tested assays, SACS showed a higher affinity towards the epidermal growth factor receptor (EGFR).
In other words, SACS inhibited the epidermal growth factor receptor (EGFR). associated with facilitating cancer cell growth and proliferation.
In order to reveal more information about alliin colonic protective effects, researchers compared the protective efficiency of three garlic powders with increased levels of alliin, obtained from bulbs grown in soils with different levels of sulfur fertilization, against DNA damage.
According to the comet assay, garlic powders were administered to rats for 2 weeks (5% of the diet), DNA damage induced by 1,2-dimethylhydrazine in the colon were also decreased strongly by the three garlic powders.
Interestingly, these decreases were not correlated to the allicin content of the garlic powders.
These results suggested that all compounds in the garlic including alliin worked synergistically to promote the efficacy of the whole food.
Sadly, feeding garlic powders protected the colon cells against DNA damage but did not modify the genotoxic activity of the direct-acting carcinogen methyl nitrosourea in the colon.
Taken altogether, alliin may be considered supplement for the prevention and treatment of colorectal cancer with no side effects, responding to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) EGFR gene regulation in colorectal cancer cells by garlic phytocompounds with special emphasis on S-Allyl-L-Cysteine Sulfoxide by Roy N1, Nazeem PA2, Babu TD3, Abida PS2, Narayanankutty A3, Valsalan R2, Valsala PA2, Raghavamenon AC. (PubMed)
(2) Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content by Singh V1, Belloir C, Siess MH, Le Bon AM. (PubMed)
(3) High-fat Western diet-induced obesity contributes to increased tumor growth in mouse models of human colon cancer by O'Neill AM1, Burrington CM2, Gillaspie EA3, Lynch DT2, Horsman MJ2, Greene MW. (PubMed)
#Cranberry Powders Process Anti-Hyperglycemia Associated withReduced Risk of Diabetics Complications, Researchers Say
Kyle J, Norotn
Diabetes is a medical and chronic disease characterized by insufficient insulin entering the bloodstream to regulate glucose.
The disease is either caused by cells in the pancreas that died off or receptor sites clogged up by fat and cholesterol, such as type 2 diabetes.
Most cases of type 1 diabetes are associated with a gene mutation that causes the immune to attack the insulin-producing beta cells in the pancreas.
Acquired diabetes in most cases is caused by unhealthy lifestyle choices, including high-fat diet and physical inactivity.
According to the statistics provided by the CDC, approximately 23.1 million people in the United States are living with diagnosed diabetes, costing the healthcare system more than $245 billion per year.
Sadly, there is an estimation that another 7.2 million people have diabetes but remain undiagnosed, accompanied by another 84.1 million adults 18 years and older with prediabetes.
Hyperglycemia, a hallmark of diabetes is a condition of abnormally high blood glucose in the blood.
Most cases of hyperglycemia are a result of poor management of blood glucose including uncontrol diet, physical inactivity, miss-medication and improper use of insulin injection.
Uncontrolled diabetes or hyperglycemia over the long term can lead to diabetic complications, including coronary heart disease, stroke, hypertension, depression, pain, polypharmacy, and functional disability.
Long-term elevated glucose values above 180 to 200 milligrams per deciliter (mg/dL), or 10 to 11 millimoles per liter (mmol/L) has been found to induce symptoms of frequent urination, increased thirst, blurred vision, fatigue, and headache.
In severe cases, some patients may also experience life-threatening complications such as fruity-smelling breath, shortness of breath, weakness, confusion, and coma.
Dr in the study of hyperglycemia in the aging population wrote, "Higher levels of Sirt1 and PGC-1α and increased expression of gluconeogenesis pathway genes are found in the hyperglycemic NOD mice. Increased Sirt6 abundance is found in the hyperglycemic NOD mice, which might increase DNA damage repair".
And, "With aging, lower Sirt1 abundance and activity, increased acetylated histone modifications and Sirt7 levels, and NOR methylation is found. Thus, whereas in normal aging cell metabolism is reduced, in the diabetic mice a compensatory mechanism may elevate Sirt1 and Sirt6 levels, increasing gluconeogenesis and DNA repair from the oxidative damage caused by hyperglycemia".
The onion is a plant in the genus Allium, belonging to the family Alliaceae, which is closely related to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of diabetes complications, researchers examined the effect of aqueous solutions of two different cranberry powders (CP and CP-SAB) on hyperglycemia.
In vitro, in vitro CP and CP-SAB administration showed a significant inhibition of α-amylase, α-glucosidase, and angiotensin I-converting enzyme (ACE) associated with the management of hyperglycemia linked to type 2 diabetes.
Low levels of α-amylase have been found in patients with diabetes.
α-glucosidase is associated with the digestion of carbohydrates is elevated in patients with diabetes
According to the chemical analysis, the efficacy of CP and CP-SAB that inhibits hyperglycemia was probably attributed to the chemical constituents p-Coumaric acid and quercetin derivatives, the main phenolic compounds identified in the cranberry powders.
Furthermore, increased with increased dose (1-5 mg/mL) of CP-SAB exerted the increased α-glucosidase inhibitory activity from 60% to 100%.
At 5 mg/mL, CP-SAB exerted a maximum of 40% inhibition against α-amylase.
Levels of ACE were also significantly inhibited by CP-SAB at the concentration of 100 and 200 mg/mL sample concentrations.
Based on the results, researchers wrote, "These in vitro results indicate the potential of cranberry powders as a dietary supplement and food-based strategies for potential hyperglycemia management".
Taken altogether, cranberry may be considered a remedy for the management of hyperglycemia, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Potential of cranberry powder for management of hyperglycemia using in vitro models by Pinto Mda S1, Ghaedian R, Shinde R, Shetty K. (PubMed)
(2) Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes by Flávia Gerelli Ghiraldini,1 Ana Carolina Vitolo Crispim, and Maria Luiza Silveira Mello. (PMC)
Diabetes is a medical and chronic disease characterized by insufficient insulin entering the bloodstream to regulate glucose.
The disease is either caused by cells in the pancreas that died off or receptor sites clogged up by fat and cholesterol, such as type 2 diabetes.
Most cases of type 1 diabetes are associated with a gene mutation that causes the immune to attack the insulin-producing beta cells in the pancreas.
Acquired diabetes in most cases is caused by unhealthy lifestyle choices, including high-fat diet and physical inactivity.
According to the statistics provided by the CDC, approximately 23.1 million people in the United States are living with diagnosed diabetes, costing the healthcare system more than $245 billion per year.
Sadly, there is an estimation that another 7.2 million people have diabetes but remain undiagnosed, accompanied by another 84.1 million adults 18 years and older with prediabetes.
Hyperglycemia, a hallmark of diabetes is a condition of abnormally high blood glucose in the blood.
Most cases of hyperglycemia are a result of poor management of blood glucose including uncontrol diet, physical inactivity, miss-medication and improper use of insulin injection.
Uncontrolled diabetes or hyperglycemia over the long term can lead to diabetic complications, including coronary heart disease, stroke, hypertension, depression, pain, polypharmacy, and functional disability.
Long-term elevated glucose values above 180 to 200 milligrams per deciliter (mg/dL), or 10 to 11 millimoles per liter (mmol/L) has been found to induce symptoms of frequent urination, increased thirst, blurred vision, fatigue, and headache.
In severe cases, some patients may also experience life-threatening complications such as fruity-smelling breath, shortness of breath, weakness, confusion, and coma.
Dr in the study of hyperglycemia in the aging population wrote, "Higher levels of Sirt1 and PGC-1α and increased expression of gluconeogenesis pathway genes are found in the hyperglycemic NOD mice. Increased Sirt6 abundance is found in the hyperglycemic NOD mice, which might increase DNA damage repair".
And, "With aging, lower Sirt1 abundance and activity, increased acetylated histone modifications and Sirt7 levels, and NOR methylation is found. Thus, whereas in normal aging cell metabolism is reduced, in the diabetic mice a compensatory mechanism may elevate Sirt1 and Sirt6 levels, increasing gluconeogenesis and DNA repair from the oxidative damage caused by hyperglycemia".
The onion is a plant in the genus Allium, belonging to the family Alliaceae, which is closely related to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of diabetes complications, researchers examined the effect of aqueous solutions of two different cranberry powders (CP and CP-SAB) on hyperglycemia.
In vitro, in vitro CP and CP-SAB administration showed a significant inhibition of α-amylase, α-glucosidase, and angiotensin I-converting enzyme (ACE) associated with the management of hyperglycemia linked to type 2 diabetes.
Low levels of α-amylase have been found in patients with diabetes.
α-glucosidase is associated with the digestion of carbohydrates is elevated in patients with diabetes
According to the chemical analysis, the efficacy of CP and CP-SAB that inhibits hyperglycemia was probably attributed to the chemical constituents p-Coumaric acid and quercetin derivatives, the main phenolic compounds identified in the cranberry powders.
Furthermore, increased with increased dose (1-5 mg/mL) of CP-SAB exerted the increased α-glucosidase inhibitory activity from 60% to 100%.
At 5 mg/mL, CP-SAB exerted a maximum of 40% inhibition against α-amylase.
Levels of ACE were also significantly inhibited by CP-SAB at the concentration of 100 and 200 mg/mL sample concentrations.
Based on the results, researchers wrote, "These in vitro results indicate the potential of cranberry powders as a dietary supplement and food-based strategies for potential hyperglycemia management".
Taken altogether, cranberry may be considered a remedy for the management of hyperglycemia, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Potential of cranberry powder for management of hyperglycemia using in vitro models by Pinto Mda S1, Ghaedian R, Shinde R, Shetty K. (PubMed)
(2) Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes by Flávia Gerelli Ghiraldini,1 Ana Carolina Vitolo Crispim, and Maria Luiza Silveira Mello. (PMC)
#Healthy Food #Broccoli' SFN Induces Cell Apoptosis and Cell Cycle Arrests in Lung Cancer, Researchers Show
Kyle J. Norton
The lung-formed part of the circulatory system plays an essential and unique role in taking oxygen to the blood and exhaling carbon dioxide from the blood.
Additionally, the lung also processes other abilities in protecting our body against disease, including
* By balancing the pH levels, the lung protects the body against the accumulation of too much carbon dioxide. High levels of carbon dioxide are known to induce acidity in the body.
* By removing small blood clots the lung protects the body against the forming of air embolisms.
* The airflow produced by the lungs also helps us to speak.
* The lung also protects against the infection through the secretion of immunoglobulin A.
Any part of the lung injury can reduce lung function, leading to either obstructive or restrictive lung diseases or mixed lung disease, depending on a person's breathing.
Lung cancer is a chronic medical condition characterized by abnormal growth of the cells in the lung tissue.
The most common form of primary lung cancer is derived from epithelial cells.
The exact cause of lung cancer is not identified. However, epidemiologically, smoking, second smoke, exposure to certain chemicals, family history, people who have lung disease, and excessive drinking are some prevalent factors associated with lung cancer development.
According to the statistics provided by the American Cancer Society, lung cancer accounts for 14% of all new cancers diagnosed in the US. In 2018, there were about 234,030 new cases of lung cancer (121,680 in men and 112,350 in women). Lung cancer also caused the death of 83,550 men and 70,500 women in the same year.
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
With an aim to find a natural food for the prevention and treatment of cancer, researchers examined the chemopreventive role of SFN through the inhibition of histone deacetylase (HDAC) associated with the regulation of DNA expression, in two different lung cancer cells by in vitro and in vivo mouse models.
According to the experimental results from A549 and H1299 lung cancer cells were treated with SFN for 48h,
* SFN inhibited HDAC activity and increased the levels of acetylated histones H3 and H4 involved in cell death in all two lung cancer cells.
* Furthermore, SFN induced cancer cell apoptosis, increased the accumulation of cells at G0/G1 and G2/M, and arrested cells at the S phase.
* Moreover, SFN also suppressed lung cancer growth in a xenograft mouse model in vivo.
Based on the results, researchers wrote, " the chemopreventive effect of SFN is associated with inhibition of HDAC activity, thereby attenuating lung cancer growth. Therefore, these findings suggest that SFN may be a therapeutic agent for lung cancer through the inhibition of HDAC".
Taken altogether, broccoli processed abundantly SFN may be considered supplements for the prevention of lung cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sulforaphane suppresses in vitro and in vivo lung tumorigenesis through downregulation of HDAC activity by Jiang LL1, Zhou SJ1, Zhang XM2, Chen HQ2, Liu W. (PubMed)
The lung-formed part of the circulatory system plays an essential and unique role in taking oxygen to the blood and exhaling carbon dioxide from the blood.
Additionally, the lung also processes other abilities in protecting our body against disease, including
* By balancing the pH levels, the lung protects the body against the accumulation of too much carbon dioxide. High levels of carbon dioxide are known to induce acidity in the body.
* By removing small blood clots the lung protects the body against the forming of air embolisms.
* The airflow produced by the lungs also helps us to speak.
* The lung also protects against the infection through the secretion of immunoglobulin A.
Any part of the lung injury can reduce lung function, leading to either obstructive or restrictive lung diseases or mixed lung disease, depending on a person's breathing.
Lung cancer is a chronic medical condition characterized by abnormal growth of the cells in the lung tissue.
The most common form of primary lung cancer is derived from epithelial cells.
The exact cause of lung cancer is not identified. However, epidemiologically, smoking, second smoke, exposure to certain chemicals, family history, people who have lung disease, and excessive drinking are some prevalent factors associated with lung cancer development.
According to the statistics provided by the American Cancer Society, lung cancer accounts for 14% of all new cancers diagnosed in the US. In 2018, there were about 234,030 new cases of lung cancer (121,680 in men and 112,350 in women). Lung cancer also caused the death of 83,550 men and 70,500 women in the same year.
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
With an aim to find a natural food for the prevention and treatment of cancer, researchers examined the chemopreventive role of SFN through the inhibition of histone deacetylase (HDAC) associated with the regulation of DNA expression, in two different lung cancer cells by in vitro and in vivo mouse models.
According to the experimental results from A549 and H1299 lung cancer cells were treated with SFN for 48h,
* SFN inhibited HDAC activity and increased the levels of acetylated histones H3 and H4 involved in cell death in all two lung cancer cells.
* Furthermore, SFN induced cancer cell apoptosis, increased the accumulation of cells at G0/G1 and G2/M, and arrested cells at the S phase.
* Moreover, SFN also suppressed lung cancer growth in a xenograft mouse model in vivo.
Based on the results, researchers wrote, " the chemopreventive effect of SFN is associated with inhibition of HDAC activity, thereby attenuating lung cancer growth. Therefore, these findings suggest that SFN may be a therapeutic agent for lung cancer through the inhibition of HDAC".
Taken altogether, broccoli processed abundantly SFN may be considered supplements for the prevention of lung cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sulforaphane suppresses in vitro and in vivo lung tumorigenesis through downregulation of HDAC activity by Jiang LL1, Zhou SJ1, Zhang XM2, Chen HQ2, Liu W. (PubMed)
#Honey Inhibits the Degradation of Aggrecan and Collagen-II Associated with Osteoarthritis (OA)
Kyle J, Norton
In seeking natural therapy with no side effects, scientists may have an herbal remedy for the prevention and treatment of osteoarthritis, according to studies.
Osteoarthritis (OA) is a common chronic inflammatory joint disease characterized by the breaking down of joint cartilage and the underlying bone.
Genetic predisposition, overweight, obesity, injury, and overuse of the joints are the most common risk factor associated with the onset of the disease.
Occupation with the repetitive movements of the joint is most affected by the disease.
Interestingly, osteoarthritis symptoms can come and go throughout the day and vary from person to person. The weather change has been one of the most complaints that trigger the symptoms of OA in the elderly.
Most common symptoms, according to epidemiological studies include joint pain, tenderness, and lack of flexibility and stiffness.
Some osteoporotic patients may also experience symptoms of grating sensation and bone spurs.
If you experience some of the above symptoms, you may have osteoarthritis.
Some researchers suggested that obesity may be one of the major risk factors besides the occupation with the repetitive movement of osteoarthritis in the Western world.
Dr. Lauren K. King, the lead scientist in the investigation of obesity & osteoarthritis, wrote, "The most significant impact of obesity on the musculoskeletal system is associated with osteoarthritis (OA), a disabling degenerative joint disorder characterized by pain, decreased mobility, and negative impact on quality of life".
And, "Obesity is associated with the incidence and progression of OA of both weight-bearing and non-weight-bearing joints, to rate of joint replacements as well as operative complications".
The finding strongly indicated the risk of osteoarthritis is increased by many folds in the obese population, compared to those with a healthy weight.
Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.
The liquid is considered healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In the concerns of widespread osteoarthritis (OA), a chronic degenerative joint disease, researchers investigated chrysin, a natural flavonoid extracted from honey and propolis anti-inflammatory effects.
The study included human OA chondrocytes pretreated with chrysin (1, 5, 10 μM) for 2 h and subsequently stimulated with IL-1β, an inflammatory cytokine for 24 h.
Injection of chrysin exerted a strong inhibition activity against the degradation of aggrecan and collagen-II.
Chrysin significantly inhibited the IL-1β-induced production of inflammatory cytokines such as degradation of c of NO and PGE2; expression of COX-2, iNOS.
Furthermore, chrysin also reduced the expression of matrixes such as MMP-1, MMP-3, MMP-13, and enzymes ADAMTS-4, and ADAMTS-5 associated with the progression and destruction of joints in early osteoarthritis.
In the depth analysis researchers also found that chrysin dramatically blocked IL-1β-stimulated IκB-α degradation in the activation of protein NF-κB-induced production of proinflammatory cytokines.
The results suggested that chrysin inhibits the progression of OA through several mechanisms, including enzymes and proteins involving the destruction of joint tissues.
Taken altogether, honey processed with a bioactive compound chrysin may be considered a functional remedy for the prevention and treatment of OA, with no side effects, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chrysin Attenuates IL-1β-Induced Expression of Inflammatory Mediators by Suppressing NF-κB in Human Osteoarthritis Chondrocytes by Zheng W1, Tao Z1, Cai L1, Chen C1, Zhang C1, Wang Q1, Ying X1, Hu W1, Chen H2. (PubMed)
(2) Obesity & osteoarthritis by Lauren K. King,* Lyn March,** and Ananthila Anandacoomarasamy. (PMC)
In seeking natural therapy with no side effects, scientists may have an herbal remedy for the prevention and treatment of osteoarthritis, according to studies.
Osteoarthritis (OA) is a common chronic inflammatory joint disease characterized by the breaking down of joint cartilage and the underlying bone.
Genetic predisposition, overweight, obesity, injury, and overuse of the joints are the most common risk factor associated with the onset of the disease.
Occupation with the repetitive movements of the joint is most affected by the disease.
Interestingly, osteoarthritis symptoms can come and go throughout the day and vary from person to person. The weather change has been one of the most complaints that trigger the symptoms of OA in the elderly.
Most common symptoms, according to epidemiological studies include joint pain, tenderness, and lack of flexibility and stiffness.
Some osteoporotic patients may also experience symptoms of grating sensation and bone spurs.
If you experience some of the above symptoms, you may have osteoarthritis.
Some researchers suggested that obesity may be one of the major risk factors besides the occupation with the repetitive movement of osteoarthritis in the Western world.
Dr. Lauren K. King, the lead scientist in the investigation of obesity & osteoarthritis, wrote, "The most significant impact of obesity on the musculoskeletal system is associated with osteoarthritis (OA), a disabling degenerative joint disorder characterized by pain, decreased mobility, and negative impact on quality of life".
And, "Obesity is associated with the incidence and progression of OA of both weight-bearing and non-weight-bearing joints, to rate of joint replacements as well as operative complications".
The finding strongly indicated the risk of osteoarthritis is increased by many folds in the obese population, compared to those with a healthy weight.
Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.
The liquid is considered healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In the concerns of widespread osteoarthritis (OA), a chronic degenerative joint disease, researchers investigated chrysin, a natural flavonoid extracted from honey and propolis anti-inflammatory effects.
The study included human OA chondrocytes pretreated with chrysin (1, 5, 10 μM) for 2 h and subsequently stimulated with IL-1β, an inflammatory cytokine for 24 h.
Injection of chrysin exerted a strong inhibition activity against the degradation of aggrecan and collagen-II.
Chrysin significantly inhibited the IL-1β-induced production of inflammatory cytokines such as degradation of c of NO and PGE2; expression of COX-2, iNOS.
Furthermore, chrysin also reduced the expression of matrixes such as MMP-1, MMP-3, MMP-13, and enzymes ADAMTS-4, and ADAMTS-5 associated with the progression and destruction of joints in early osteoarthritis.
In the depth analysis researchers also found that chrysin dramatically blocked IL-1β-stimulated IκB-α degradation in the activation of protein NF-κB-induced production of proinflammatory cytokines.
The results suggested that chrysin inhibits the progression of OA through several mechanisms, including enzymes and proteins involving the destruction of joint tissues.
Taken altogether, honey processed with a bioactive compound chrysin may be considered a functional remedy for the prevention and treatment of OA, with no side effects, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chrysin Attenuates IL-1β-Induced Expression of Inflammatory Mediators by Suppressing NF-κB in Human Osteoarthritis Chondrocytes by Zheng W1, Tao Z1, Cai L1, Chen C1, Zhang C1, Wang Q1, Ying X1, Hu W1, Chen H2. (PubMed)
(2) Obesity & osteoarthritis by Lauren K. King,* Lyn March,** and Ananthila Anandacoomarasamy. (PMC)
#Phytochemical I3C and 3,3'-#Diindolylmethane Exhibit Liver Protection through Pleiotropic Mechanism, Researchers Find
Kyle J. Norton
Scientists may have found a bioactive ingredient that processes liver protective activity with no side effects, according to studies.
Hepatic protection is an action in which substances including medicine and herbal remedy were used to protect the liver against damage.
The liver is the largest internal organ with a function that filters the blood from the intestinal tract before passing it to the heart and other parts of the body.
Additionally, the liver also produces bile to aid digestion and cholesterol to build strong cell membranes, produce of vitamin D and steroid hormones.
Liver disease is a broad term including any problems that cause the reduced function of the liver.
There are many risk factors that liver problems. Most cases of liver disease are diagnosed in the advanced stage, it takes years to develop.
In other words, symptoms of liver disease can be felt only after more than 75% liver is damaged.
The most common risk factors are genetic predisposition, viruses, and long-term excessive alcohol drinking.
Non-alcoholic fatty disease (NAFLD), a leading cause of cirrhosis, is one of the most common liver disease found in the Western world, affecting up to 25% of people in the United States.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In the urgency of finding a natural compound with liver protective activity, researchers examined the pharmacokinetics of I3C and its derivatives, including 3,3'-Diindolylmethane or DIM multiple protective roles in the processes of chronic liver diseases.
Administration of I3C and its derivatives relieved liver oxidative stress by regulating transcriptional factors and their respective signaling pathways associated with the synthesis of DNA to influence the activation, proliferation, and apoptosis of target cells.
Furthermore, indoles not only modulated the enzymes that are relevant to hepatitis viral replication, lipogenesis, and the metabolism associated with liver function but also protected the liver against hepatotoxicity (ethanol and some hepatotoxic substances).
In other words, the indoles exerted hepatoprotection by inhibiting pro-inflammatory cytokines and chemokines against microbial-induced liver injuries.
Based on the findings, Dr. Wang SQ, the lead scientist said, "Indoles, especially I3C and DIM as phytochemicals, exert anti-fibrosis, anti-tumor, anti-oxidant, immunomodulatory, detoxification and anti-inflammation effects on hepatic protection through pleiotropic mechanism".
And, " I3C and DIM as phytochemicals, exert anti-fibrosis, anti-tumor, anti-oxidant, immunomodulatory, detoxification and anti-inflammation effects on hepatic protection through pleiotropic mechanism".
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of liver diseases, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Indole-3-Carbinol (I3C) and its Major Derivatives: Their Pharmacokinetics and Important Roles in Hepatic Protection by Wang SQ, Cheng LS, Liu Y, Wang JY, Jiang W. (PubMed)
(2) Induction of hepatic CYP1A by indole-3-carbinol in protection against aflatoxin B1 hepatocarcinogenesis in rainbow trout by Takahashi N1, Stresser DM, Williams DE, Bailey GS. (PubMed)
Scientists may have found a bioactive ingredient that processes liver protective activity with no side effects, according to studies.
Hepatic protection is an action in which substances including medicine and herbal remedy were used to protect the liver against damage.
The liver is the largest internal organ with a function that filters the blood from the intestinal tract before passing it to the heart and other parts of the body.
Additionally, the liver also produces bile to aid digestion and cholesterol to build strong cell membranes, produce of vitamin D and steroid hormones.
Liver disease is a broad term including any problems that cause the reduced function of the liver.
There are many risk factors that liver problems. Most cases of liver disease are diagnosed in the advanced stage, it takes years to develop.
In other words, symptoms of liver disease can be felt only after more than 75% liver is damaged.
The most common risk factors are genetic predisposition, viruses, and long-term excessive alcohol drinking.
Non-alcoholic fatty disease (NAFLD), a leading cause of cirrhosis, is one of the most common liver disease found in the Western world, affecting up to 25% of people in the United States.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In the urgency of finding a natural compound with liver protective activity, researchers examined the pharmacokinetics of I3C and its derivatives, including 3,3'-Diindolylmethane or DIM multiple protective roles in the processes of chronic liver diseases.
Administration of I3C and its derivatives relieved liver oxidative stress by regulating transcriptional factors and their respective signaling pathways associated with the synthesis of DNA to influence the activation, proliferation, and apoptosis of target cells.
Furthermore, indoles not only modulated the enzymes that are relevant to hepatitis viral replication, lipogenesis, and the metabolism associated with liver function but also protected the liver against hepatotoxicity (ethanol and some hepatotoxic substances).
In other words, the indoles exerted hepatoprotection by inhibiting pro-inflammatory cytokines and chemokines against microbial-induced liver injuries.
Based on the findings, Dr. Wang SQ, the lead scientist said, "Indoles, especially I3C and DIM as phytochemicals, exert anti-fibrosis, anti-tumor, anti-oxidant, immunomodulatory, detoxification and anti-inflammation effects on hepatic protection through pleiotropic mechanism".
And, " I3C and DIM as phytochemicals, exert anti-fibrosis, anti-tumor, anti-oxidant, immunomodulatory, detoxification and anti-inflammation effects on hepatic protection through pleiotropic mechanism".
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of liver diseases, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Indole-3-Carbinol (I3C) and its Major Derivatives: Their Pharmacokinetics and Important Roles in Hepatic Protection by Wang SQ, Cheng LS, Liu Y, Wang JY, Jiang W. (PubMed)
(2) Induction of hepatic CYP1A by indole-3-carbinol in protection against aflatoxin B1 hepatocarcinogenesis in rainbow trout by Takahashi N1, Stresser DM, Williams DE, Bailey GS. (PubMed)
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