Kyle J. Norton
Chaste tree berry processes both estrogenic and anti-estrogenic properties and may be considered a functional food for women with delayed aging progression, restored hormone balance in ameliorated menstrual disorders, alleviated menopausal symptoms, and more........
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belongings to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.
Estrogenic Property
Chaste tree berry (Vitex agnus-castus L.) displaced estrogenic ability induced the reaction of estrogen from the binding site of estrogen receptors alpha (ERalpha) and beta (ERbeta), in ameliorated the deregulation of 17β-Estradiol (E2) in exhibited the initiation and progression of cell malignancies, affecting various aspect in women body, a study by respectable Institute suggested.
According to the University of Illinois at Chicago, linoleic acid isolated from the extract of Vitex agnus-castus exerted estrogenic activity in binding to estrogen receptors, inducing certain estrogen-inducible gene expression in preserving the integrity of the genome, presented in a cell or organism.
Dr. Jarry H, the lead author in the study of "evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones" found that besides linoleic acid, flavones derivative vitexin and Pendleton. isolated from Vitex agnus-castus (VAC) also expressed the estrogenic effect as the most active ERss-selective phytoestrogens.
Anti-estrogen Property
Chaste tree berry(Vitex agnus-castus), also processes anti-estrogenic properties in binding the estrogen receptors for a balance between the activities of estrogen receptor ERα or ERβ.
Anti-estrogenic effects are an act of binding the estrogen receptor(ERα ) and/ERβ in inhibiting the excessive levels of estrogen circulating in the body.
According to the University of Alabama in Huntsville, in the study of the potential effect of estrogen mimics or anti-estrogens in phytochemicals of popular dietary herbal supplements, researchers found that almost all herbal supplements containing phytochemical components showed a capability in binding to the human estrogen receptor and exhibit selective estrogen receptor modulation, including chaste tree berry.
Casticin, a flavonoid isolated from Vitex rotundifolia, significantly expressed an anti-estrogenic effect in reduced the prolactin release stimulated by E2 in induced inhibition of ERα mRNA expression in a concentration-dependent manner, through its anti-estrogenic effect.
In hyperprolactinemia (MIHP) induced by the administration of metoclopramide dihydrochloride (50 mg/kg, tid, ip, for 10 d) in SD rats, application of casticin (10, 20, and 40 mg/kg, ip, for 7 d) reduced serum prolactin levels by 33.9%, 54.3%, and 64.7% and at(1 and 10 micromol/L) inhibited E2-induced pituitary cell proliferation by 27.7% and 42.1%, respectively through reduced levels of 17β-Estradiol (E2) significantly.
More importantly, oral administration of casticin, a flavonoid isolated from Vitex rotundifolia displayed an anti-estrogenic activity in decreasing excessive levels of 17β-Estradiol (E2) significantly
Summary
Chaste tree berry(Vitex agnus-castus) exerts estrogenic components of plant extracts that may constitute a potential use for some dietary supplements in humans for the treatment of various estrogen-related syndromes and diseases, including breast and prostate cancers, menopausal symptoms, osteoporosis, atherosclerosis and stroke, and neurodegeneration and anti-estrogenic effects in binding estrogen receptor site to preserve the balancing of hormone expression of estrogen through ER-alpha and ERBeta inhibition and exhibition by regulating the function of some estrogen-inducible genes.
In other words, chaste tree berries stimulated estrogen receptors in the release of estrogen into the blood in case of deficiency or inhibited extra levels of estrogen in case of excess maintenance hormone balancing with other sex hormones.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Sources
(1) Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry) by Liu J1, Burdette JE, Sun Y, Deng S, Schlecht SM, Zheng W, Nikolic D, Mahady G, van Breemen RB, Fong HH, Pezzuto JM, Bolton JL, Farnsworth NR. (PubMed)
(2) Evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones by Jarry H1, Spengler B, Porzel A, Schmidt J, Wuttke W, Christoffel V.(PubMed)
(3) Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms by Liu J1, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL.(PubMed)
(4) Health effects of phytoestrogens by Branca F1, Lorenzetti S.(PubMed)
(5) A molecular docking study of phytochemical estrogen mimics from dietary herbal supplements by Powers CN1, Setzer WN1.(PubMed)
(6) Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro by YE Q1, ZHANG QY, ZHENG CJ, WANG Y, QIN LP.(PubMed)
Monday 31 July 2023
MK615, an Extract Mixture of #Hydrophobic Substances from Japanese Apricot Process Anti-#BreastCancer Activity, Scientists Say
Kyle J. Norton
Finding a cure for breast cancer from botanical plants without inducing side effects has been a lifetime dream of many scientists. Unfortunately, as of today, the finding is still ongoing without much success.
However, according to some studies, apricot, the edible fruit may be the next pharmaceutical target to extract potential ingredients for the cure for breast cancer.
Breast cancer is a medical and chronic condition as the result of irregular cell growth originating from the breast tissue. why women in the same health conditions, family history, and race, some are prone to develop the early onset of the disease while others do not.
Breast cancer is caused by the alternation of DNA of the cells in the breast tissue. Epidemiologically, certain prevalent factors are associated with an increased risk of the disease.
According to the probability for women to develop or die from breast cancer provided by the Canadian Cancer Statistics publication, the lifetime risk of a woman to develop is 1/8 and 1/31 of them will die from the disease.
The 5 years survival rate of the early stage of breast cancer is 100% compared to much less in the advanced stage.
Therefore, women with higher risk such as genetic preposition of genes BRAC1 and 2 should have their breast mammogram taken every year.
More importantly, Dr. Zainab Taha, the lead author in the study "The Role of Diet and Lifestyle in Women with Breast Cancer: An Update Review of Related Research in the Middle East" wrote,
"There is an alarming epidemic of obesity among women in most of the EMR countries, especially Gulf Coopers Action Council (GCC) countries. The rise in the new breast cancer cases among women could be attributed to excess body weight. Their dietary pattern, which correlates with obesity, can be an important factor in the etiology of cancer.".
These results strongly suggested that diet and lifestyle associated with the onset of obesity are major contributors to the early onset of breast cancer.
In other words, if you follow a healthy diet with a lot of fruits and vegetables, whole grains with less in saturated and trans fat, red meat, and processed and a lifestyle with moderate exercise, you are at the lower end of the risk factor scale of breast cancer.
The apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belongs to the family Rosaceae. Apricot is classified with the family of plum and has yellow to orange, often tinged red on the side which is exposed to the sun.
In the reaffirming of the MK615, an extract mixture containing hydrophobic substances from Japanese apricot. anti-cancer possibility, researchers at the Dokkyo University School of Medicine conducted an evaluation to examine the antineoplastic effects of MK615 against breast cancer cells.
The experiment includes 2 breast cancer cell lines, MDA-MB-468 (MDA) and MCF7, was cultured with (600, 300, and 150 mg/mL) or without MK615.
After 72 hours of incubation, researchers showed that
* MK615 inhibited the growth of MDA and MCF7 in a dose-dependent manner.
* The percentage growth inhibition of MDA at dosages of 600, 300, and 150 mg/mL was 59.2%, 52.4%, and 23.3%, respectively, and that for MCF7 was 83.5%, 52.7%, and 16.6%, respectively.
* MK615 treatment included massive vacuolization in the cytoplasm and apoptotic changes in the nucleus.
* Cell cycle analysis showed that MK615 increased the proportion of cells in the G2-M phase in both MDA (7.8-11.7%) and MCF7 (8.1-18.7%), and finally both cell lines became apoptotic.
These results suggested MK615 effectively inhibits the growth of breast cancer cells in vitro, through cell cycle arrest and apoptosis.
Furthermore, in the concerns of breast cancer continued to cause high cancer death rates among women worldwide, researchers at the joint study led by the Universiti Sains Malaysia launched an evaluation to examine the plant-based products which have demonstrated anticancer potential through different biological pathways including modulation of the immune system. Immunomodulatory properties of medicinal plants have been shown to mitigate breast cancer cell growth.
Out of the medical plants selected including Glycyrrhiza glabra, Uncaria tomentosa, Camellia sinensis, Panax ginseng, Prunus armenaica (apricot), Allium sativum, Arctium lappa and Curcuma longa, malic acid and quinic acid isolated from apricot exerted a significant activity in regulating the immune system potentially applicable in breast cancer treatment via anti-inflammatory and lymphocytes activation.
Taken together, apricot may be considered a functional food for the prevention and a secondary therapy combined with conventional medicine for the treatment of breast cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) [Studies on the chemical constituents of flowers of Prunus mume].[Article in Chinese] by Zhang QH1, Zhang L, Shang LX, Shao CL, Wu YX.(PubMed)
(1) New antineoplastic agent, MK615, from UME (a Variety of) Japanese apricot inhibits the growth of breast cancer cells in vitro by Nakagawa A1, Sawada T, Okada T, Ohsawa T, Adachi M, Kubota K. (PubMed)
(2) The Immunomodulatory Potential of Selected Bioactive Plant-Based Compounds in Breast Cancer: A Review by Baraya YS1, Wong KK2, Yaacob NS. (PubMed)
(3) The Role of Diet and Lifestyle in Women with Breast Cancer: An Update Review of Related Research in the Middle East by Zainab Taha1 and Sakina E. Eltom. (PMC)
Finding a cure for breast cancer from botanical plants without inducing side effects has been a lifetime dream of many scientists. Unfortunately, as of today, the finding is still ongoing without much success.
However, according to some studies, apricot, the edible fruit may be the next pharmaceutical target to extract potential ingredients for the cure for breast cancer.
Breast cancer is a medical and chronic condition as the result of irregular cell growth originating from the breast tissue. why women in the same health conditions, family history, and race, some are prone to develop the early onset of the disease while others do not.
Breast cancer is caused by the alternation of DNA of the cells in the breast tissue. Epidemiologically, certain prevalent factors are associated with an increased risk of the disease.
According to the probability for women to develop or die from breast cancer provided by the Canadian Cancer Statistics publication, the lifetime risk of a woman to develop is 1/8 and 1/31 of them will die from the disease.
The 5 years survival rate of the early stage of breast cancer is 100% compared to much less in the advanced stage.
Therefore, women with higher risk such as genetic preposition of genes BRAC1 and 2 should have their breast mammogram taken every year.
More importantly, Dr. Zainab Taha, the lead author in the study "The Role of Diet and Lifestyle in Women with Breast Cancer: An Update Review of Related Research in the Middle East" wrote,
"There is an alarming epidemic of obesity among women in most of the EMR countries, especially Gulf Coopers Action Council (GCC) countries. The rise in the new breast cancer cases among women could be attributed to excess body weight. Their dietary pattern, which correlates with obesity, can be an important factor in the etiology of cancer.".
These results strongly suggested that diet and lifestyle associated with the onset of obesity are major contributors to the early onset of breast cancer.
In other words, if you follow a healthy diet with a lot of fruits and vegetables, whole grains with less in saturated and trans fat, red meat, and processed and a lifestyle with moderate exercise, you are at the lower end of the risk factor scale of breast cancer.
The apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belongs to the family Rosaceae. Apricot is classified with the family of plum and has yellow to orange, often tinged red on the side which is exposed to the sun.
In the reaffirming of the MK615, an extract mixture containing hydrophobic substances from Japanese apricot. anti-cancer possibility, researchers at the Dokkyo University School of Medicine conducted an evaluation to examine the antineoplastic effects of MK615 against breast cancer cells.
The experiment includes 2 breast cancer cell lines, MDA-MB-468 (MDA) and MCF7, was cultured with (600, 300, and 150 mg/mL) or without MK615.
After 72 hours of incubation, researchers showed that
* MK615 inhibited the growth of MDA and MCF7 in a dose-dependent manner.
* The percentage growth inhibition of MDA at dosages of 600, 300, and 150 mg/mL was 59.2%, 52.4%, and 23.3%, respectively, and that for MCF7 was 83.5%, 52.7%, and 16.6%, respectively.
* MK615 treatment included massive vacuolization in the cytoplasm and apoptotic changes in the nucleus.
* Cell cycle analysis showed that MK615 increased the proportion of cells in the G2-M phase in both MDA (7.8-11.7%) and MCF7 (8.1-18.7%), and finally both cell lines became apoptotic.
These results suggested MK615 effectively inhibits the growth of breast cancer cells in vitro, through cell cycle arrest and apoptosis.
Furthermore, in the concerns of breast cancer continued to cause high cancer death rates among women worldwide, researchers at the joint study led by the Universiti Sains Malaysia launched an evaluation to examine the plant-based products which have demonstrated anticancer potential through different biological pathways including modulation of the immune system. Immunomodulatory properties of medicinal plants have been shown to mitigate breast cancer cell growth.
Out of the medical plants selected including Glycyrrhiza glabra, Uncaria tomentosa, Camellia sinensis, Panax ginseng, Prunus armenaica (apricot), Allium sativum, Arctium lappa and Curcuma longa, malic acid and quinic acid isolated from apricot exerted a significant activity in regulating the immune system potentially applicable in breast cancer treatment via anti-inflammatory and lymphocytes activation.
Taken together, apricot may be considered a functional food for the prevention and a secondary therapy combined with conventional medicine for the treatment of breast cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) [Studies on the chemical constituents of flowers of Prunus mume].[Article in Chinese] by Zhang QH1, Zhang L, Shang LX, Shao CL, Wu YX.(PubMed)
(1) New antineoplastic agent, MK615, from UME (a Variety of) Japanese apricot inhibits the growth of breast cancer cells in vitro by Nakagawa A1, Sawada T, Okada T, Ohsawa T, Adachi M, Kubota K. (PubMed)
(2) The Immunomodulatory Potential of Selected Bioactive Plant-Based Compounds in Breast Cancer: A Review by Baraya YS1, Wong KK2, Yaacob NS. (PubMed)
(3) The Role of Diet and Lifestyle in Women with Breast Cancer: An Update Review of Related Research in the Middle East by Zainab Taha1 and Sakina E. Eltom. (PMC)
#Healthyfood #OnionExtract Shows A Protective Effects Cyto and Geno-Toxicity, Reserachers Say
Kyle J. Norotn
Cytotoxicity is the process that kills cells by inducing toxic substances.
Cancer cytotoxicity is the stage of killing cancer cells by toxicity with or without inducing side effects.
Most cases of cytotoxicity of a substance are to determine the potential toxicity of the quality of the substance, including plant extracts or biologically active compounds isolated from plants.
In other words, the aim of cytotoxic studies is to find the minimal quality that is essential for the successful development of pharmaceutical or cosmetic preparation that induces cellular toxicity for the treatment of cancer.
Before the preparation can be used in humans, bioassays associated with a number of different cell lines in vitro and vivo have been used to assess the cytotoxicity of many herbal plants, including those of African medicinal plants.
Free radicals have also been found to induce cytotoxicity to cause cancer death by oxidative stress.
Dr. Clifford Fong wrote, "An analysis of the cytotoxicity data for a wide range of anti-cancer drugs applied to triple-negative breast cancer (TNBC) cells and ovarian cancer cells under normoxic, hypoxic and anoxic conditions have shown that free radical forms of the drugs are involved".
And " This finding is consistent with the known involvement of oxidative stress in the TNBC and ovarian cancer cells. A mechanism to explain the formation of these drug-free radicals and how they can be involved in oxidative stress is proposed".
Genotoxicity is the term associated with chemical agents that damages the genetic information within a cell, causing mutations of cell DNA, a major cause of cancer.
Not all genotoxicity is mutagenicity, However, all mutagens are genotoxic.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
In finding a potential compound for the treatment of cancer, researchers examined the effect of an onion extract on cyto- and genotoxicity in human lymphocytes treated with bleomycin (BLM), a radiomimetic agent.
In radiation exposure -induced oxidative DNA damage in the increased risk of cancer, the risk the richest sources of dietary flavonoids found in onion inhibited the frequency of micronuclei (MN) and DNA damage following treatment with BLM, according to the cytokinesis-blocked micronucleus assay and a single cell gel electrophoresis assay.
Phytochemicals in the onion showed a significant increase in cell viability in lymphocytes exposed to BLM compared to cells treated with BLM alone.
Onion also suppressed the increased frequency of BLM-induced MN and DNA damage in a dose-dependent manner evidenced by lymphocyte viability pretreated with onion extract (10 and 20 μL/mL).
Moreover, the frequency of BLM-induced MN was decreased at all doses of BLM, and DNA damage was decreased by the administration at 3 μg/mL of BLM.
Based on the findings, researchers said, "onion extract may have protective effects against BLM-induced cyto- and genotoxicity in human lymphocytes".
Taken altogether, onion-processed abundantly bioactive compounds may be considered a remedy for the prevention and treatment of cytotoxicity and genotoxicity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective Effect of Onion Extract on Bleomycin-Induced Cytotoxicity and Genotoxicity in Human Lymphocytes by Cho YH1,2, Lee JW3, Woo HD4, Lee S5, Kim YJ6, Lee Y7, Shin S8, Joung H9, Chung HW. (PubMed)
(2) Evaluation of cytotoxicity and genotoxicity of Hancornia speciosa latex in Allium cepa root model by Ribeiro TP1, Sousa TR1, Arruda AS1, Peixoto N1, Gonçalves PJ2, Almeida LM. (PubMed)
(3) Free radicals in chemotherapy-induced cytotoxicity and oxidative stress in triple-negative breast and ovarian cancers under hypoxic and normoxic conditions by Clifford Fong (HAL)
Cytotoxicity is the process that kills cells by inducing toxic substances.
Cancer cytotoxicity is the stage of killing cancer cells by toxicity with or without inducing side effects.
Most cases of cytotoxicity of a substance are to determine the potential toxicity of the quality of the substance, including plant extracts or biologically active compounds isolated from plants.
In other words, the aim of cytotoxic studies is to find the minimal quality that is essential for the successful development of pharmaceutical or cosmetic preparation that induces cellular toxicity for the treatment of cancer.
Before the preparation can be used in humans, bioassays associated with a number of different cell lines in vitro and vivo have been used to assess the cytotoxicity of many herbal plants, including those of African medicinal plants.
Free radicals have also been found to induce cytotoxicity to cause cancer death by oxidative stress.
Dr. Clifford Fong wrote, "An analysis of the cytotoxicity data for a wide range of anti-cancer drugs applied to triple-negative breast cancer (TNBC) cells and ovarian cancer cells under normoxic, hypoxic and anoxic conditions have shown that free radical forms of the drugs are involved".
And " This finding is consistent with the known involvement of oxidative stress in the TNBC and ovarian cancer cells. A mechanism to explain the formation of these drug-free radicals and how they can be involved in oxidative stress is proposed".
Genotoxicity is the term associated with chemical agents that damages the genetic information within a cell, causing mutations of cell DNA, a major cause of cancer.
Not all genotoxicity is mutagenicity, However, all mutagens are genotoxic.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
In finding a potential compound for the treatment of cancer, researchers examined the effect of an onion extract on cyto- and genotoxicity in human lymphocytes treated with bleomycin (BLM), a radiomimetic agent.
In radiation exposure -induced oxidative DNA damage in the increased risk of cancer, the risk the richest sources of dietary flavonoids found in onion inhibited the frequency of micronuclei (MN) and DNA damage following treatment with BLM, according to the cytokinesis-blocked micronucleus assay and a single cell gel electrophoresis assay.
Phytochemicals in the onion showed a significant increase in cell viability in lymphocytes exposed to BLM compared to cells treated with BLM alone.
Onion also suppressed the increased frequency of BLM-induced MN and DNA damage in a dose-dependent manner evidenced by lymphocyte viability pretreated with onion extract (10 and 20 μL/mL).
Moreover, the frequency of BLM-induced MN was decreased at all doses of BLM, and DNA damage was decreased by the administration at 3 μg/mL of BLM.
Based on the findings, researchers said, "onion extract may have protective effects against BLM-induced cyto- and genotoxicity in human lymphocytes".
Taken altogether, onion-processed abundantly bioactive compounds may be considered a remedy for the prevention and treatment of cytotoxicity and genotoxicity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective Effect of Onion Extract on Bleomycin-Induced Cytotoxicity and Genotoxicity in Human Lymphocytes by Cho YH1,2, Lee JW3, Woo HD4, Lee S5, Kim YJ6, Lee Y7, Shin S8, Joung H9, Chung HW. (PubMed)
(2) Evaluation of cytotoxicity and genotoxicity of Hancornia speciosa latex in Allium cepa root model by Ribeiro TP1, Sousa TR1, Arruda AS1, Peixoto N1, Gonçalves PJ2, Almeida LM. (PubMed)
(3) Free radicals in chemotherapy-induced cytotoxicity and oxidative stress in triple-negative breast and ovarian cancers under hypoxic and normoxic conditions by Clifford Fong (HAL)
#PintoBean's Lectin Inhibits Proteins Associated with Cancer Cell Proliferative Activity, According to Studies
Kyle J. Norton
Proliferation is a process of cancer growth associated with an abnormally high rate of cancer cell division, leading to rapid overgrowth of the tumor.
Cancer is a class of diseases associated with the growth of cells disorderly and uncontrollably due to the alternation of DNA.
According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Cancer cell proliferation by dividing unlimitedly, compared to normal cells that die after a certain cell cycle division.
More precisely,
* The growth of normal cells
Under normal circumstances, cell growth is a natural process without even notice, every day millions of cells grow to replace millions of dead cells and to keep our body in balance and healthy.
Sometimes, acceleration of cell growth is necessary to prevent further damage to the body organ, such as cuts, injuries, etc., but after fulfilling their purposes, the growth of cells is back to a normal rate again due to our body growth inhibitors.
Unfortunately, skin cells sometimes overgrow while healing, leading to scars to the skin.
*The primary tumor; size and growth
A primary tumor or original tumor that the tumor progression that yields a cancerous mass.
Some cancers can begin in several places, such as lymphomas and leukemias. Most cancers can not be detected until they formed a small grape-like lump.
Cancer cells need 42 doublings before they can produce enough cancer cells to cause death.
According to the statistics provided by the National Cancer Institute, In 2018, approximately 1,735,350 cases of cancer were diagnosed in the US and the disease also caused the death of 609,640 Americans.
In finding a natural ingredient for the prevention and treatment of cancers, scientists examined the antiproliferative effects of Lectins (hemagglutinins) from the common edible bean Phaseolus vulgaris cv. Hokkaido large pinto bean.
The pinto bean is also known as the common bean, genus Phaseolus and the family Fabaceae. It has a mottled appearance of darker reddish-brown spots on a lighter brownish-beige background, thus appearing painted or spotted.
According to the tested analysis of a 60 kDa dimeric hemagglutinin with a blocked N-terminus was isolated in large yield (190 mg/60 g) from the pinto beans,
* The administration of 60 kDa showed an inhibitory proliferation of nasopharyngeal carcinoma (CNE2), human breast cancer (MCF7), and hepatoma (HepG2) cells.
* The IC50 values were considered relatively low among lectins of different P. vulgaris cultivars toward HepG2, MCF7, and CNE2 cells after treatment for 48 h were 8.1, 6.07, and 7.49 μM, respectively,
In other words, the lectin found in the pinto bean as sugar-binding proteins or glycoproteins with various biological activities exerted a promising remedy for the treatment of cancers in vitro.
Taken altogether, Pinto beans may be considered a promising anti-proliferative functional food, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Isolation of a Hemagglutinin with Potent Antiproliferative Activity and a Large Antifungal Defensin from Phaseolus vulgaris cv. Hokkaido Large Pinto Beans by Yin C1, Wong JH1, Ng TB. (PubMed)
Proliferation is a process of cancer growth associated with an abnormally high rate of cancer cell division, leading to rapid overgrowth of the tumor.
Cancer is a class of diseases associated with the growth of cells disorderly and uncontrollably due to the alternation of DNA.
According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Cancer cell proliferation by dividing unlimitedly, compared to normal cells that die after a certain cell cycle division.
More precisely,
* The growth of normal cells
Under normal circumstances, cell growth is a natural process without even notice, every day millions of cells grow to replace millions of dead cells and to keep our body in balance and healthy.
Sometimes, acceleration of cell growth is necessary to prevent further damage to the body organ, such as cuts, injuries, etc., but after fulfilling their purposes, the growth of cells is back to a normal rate again due to our body growth inhibitors.
Unfortunately, skin cells sometimes overgrow while healing, leading to scars to the skin.
*The primary tumor; size and growth
A primary tumor or original tumor that the tumor progression that yields a cancerous mass.
Some cancers can begin in several places, such as lymphomas and leukemias. Most cancers can not be detected until they formed a small grape-like lump.
Cancer cells need 42 doublings before they can produce enough cancer cells to cause death.
According to the statistics provided by the National Cancer Institute, In 2018, approximately 1,735,350 cases of cancer were diagnosed in the US and the disease also caused the death of 609,640 Americans.
In finding a natural ingredient for the prevention and treatment of cancers, scientists examined the antiproliferative effects of Lectins (hemagglutinins) from the common edible bean Phaseolus vulgaris cv. Hokkaido large pinto bean.
The pinto bean is also known as the common bean, genus Phaseolus and the family Fabaceae. It has a mottled appearance of darker reddish-brown spots on a lighter brownish-beige background, thus appearing painted or spotted.
According to the tested analysis of a 60 kDa dimeric hemagglutinin with a blocked N-terminus was isolated in large yield (190 mg/60 g) from the pinto beans,
* The administration of 60 kDa showed an inhibitory proliferation of nasopharyngeal carcinoma (CNE2), human breast cancer (MCF7), and hepatoma (HepG2) cells.
* The IC50 values were considered relatively low among lectins of different P. vulgaris cultivars toward HepG2, MCF7, and CNE2 cells after treatment for 48 h were 8.1, 6.07, and 7.49 μM, respectively,
In other words, the lectin found in the pinto bean as sugar-binding proteins or glycoproteins with various biological activities exerted a promising remedy for the treatment of cancers in vitro.
Taken altogether, Pinto beans may be considered a promising anti-proliferative functional food, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Isolation of a Hemagglutinin with Potent Antiproliferative Activity and a Large Antifungal Defensin from Phaseolus vulgaris cv. Hokkaido Large Pinto Beans by Yin C1, Wong JH1, Ng TB. (PubMed)
#Healthyfood #GreenLeafyVeggies Inhibit Levels of Cholesterol through Their Bile Acid Binding Activity, Researchers Suggest
Kyle J. Norton
Bile acids are synthesized by oxidation from cholesterol in the liver, flowing to the gallbladder to aid digestion.
Cholesterol is a waxy substance that is produced either by the liver or injected from animal food sources.
Cholesterol found in our body is needed for our body to build cell walls, hormones, and vitamin D, and create bile salts that aid digestion. However, too much of them, in most cases due to the intake of animal protein can cause plaques to build up on the arterial wall, the major cause of heart disease and stroke.
Bile acid-binding is a process that interferes with normal fat digestion and absorption including the prevention of absorption of fat-soluble vitamins such as A, D, E, and K.
In other words, the binding of bile acids (BAs) may have a strong effect to lower blood cholesterol levels by increasing the excretion of bile acids in the stool and reducing the amount of bile acid returning to the liver.
By inhibiting the levels of bile acid caused by a certain type of liver/bile duct disease such as partial biliary obstruction, levels of cholesterol can be controlled.
Conventionally, the effects of bile acid sequestrant are limited. Low doses of 8 grams/day of Cholestyramine, a bile acid sequestrant, which binds bile in the gastrointestinal tract to prevent its reabsorption can lower LDL cholesterol by 10%-15% compared to high doses of 24 grams/day of only 25%.
In other words, bile acid-binding medicine such as Cholestyramine, used alone is less effective, compared to statins in lowering LDL cholesterol.
The most common symptoms associated with the intake of Cholestyramine are constipation, diarrhea, stomach/abdominal pain, bloating, nausea, vomiting, and loss of appetite.
In finding a potential plant that processes anti-high blood cholesterol activity, researchers compared the bile acid-binding potential that lowers the risk of heart disease and cancer of various vegetables.
Compared to Cholestyramine (a cholesterol-lowering, bile acid-binding drug) that was used as the positive control treatment and cellulose as the negative control, researchers found that* Relative to cholestyramine, in vitro bile acid binding on dry matter basis was for the collard greens, kale, and mustard greens, 13%; broccoli, 10%; Brussels sprouts and spinach, 8%; green bell pepper, 7%; and cabbage, 5%.
In other words, collard greens = kale = mustard greens showed the strongest healthy-promoting potential in bile acid-binding compared to the following lesser extent of > broccoli > Brussels sprouts = spinach = green bell pepper > cabbage.
More importantly, steam cooking significantly improved the in vitro bile acid binding of collard greens, kale, mustard greens, broccoli, green bell pepper, and cabbage compared to vegetables raw (uncooked).
More precisely, the Inclusion of steam-cooked collard greens, kale, mustard greens, broccoli, green bell pepper, and cabbage in our daily diet may have the potential in improving healthy levels of blood cholesterol.
Collectively, researchers said, "These green/leafy vegetables, when consumed regularly after steam cooking, would lower the risk of cardiovascular disease and cancer, advance human nutrition research, and improve public health".
Taken altogether, green leafy veggies may be considered functional foods for lowering blood cholesterol, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Steam cooking significantly improves in vitro bile acid binding of collard greens, kale, mustard greens, broccoli, green bell pepper, and cabbage by Kahlon TS1, Chiu MC, Chapman MH. (PubMed)
Bile acids are synthesized by oxidation from cholesterol in the liver, flowing to the gallbladder to aid digestion.
Cholesterol is a waxy substance that is produced either by the liver or injected from animal food sources.
Cholesterol found in our body is needed for our body to build cell walls, hormones, and vitamin D, and create bile salts that aid digestion. However, too much of them, in most cases due to the intake of animal protein can cause plaques to build up on the arterial wall, the major cause of heart disease and stroke.
Bile acid-binding is a process that interferes with normal fat digestion and absorption including the prevention of absorption of fat-soluble vitamins such as A, D, E, and K.
In other words, the binding of bile acids (BAs) may have a strong effect to lower blood cholesterol levels by increasing the excretion of bile acids in the stool and reducing the amount of bile acid returning to the liver.
By inhibiting the levels of bile acid caused by a certain type of liver/bile duct disease such as partial biliary obstruction, levels of cholesterol can be controlled.
Conventionally, the effects of bile acid sequestrant are limited. Low doses of 8 grams/day of Cholestyramine, a bile acid sequestrant, which binds bile in the gastrointestinal tract to prevent its reabsorption can lower LDL cholesterol by 10%-15% compared to high doses of 24 grams/day of only 25%.
In other words, bile acid-binding medicine such as Cholestyramine, used alone is less effective, compared to statins in lowering LDL cholesterol.
The most common symptoms associated with the intake of Cholestyramine are constipation, diarrhea, stomach/abdominal pain, bloating, nausea, vomiting, and loss of appetite.
In finding a potential plant that processes anti-high blood cholesterol activity, researchers compared the bile acid-binding potential that lowers the risk of heart disease and cancer of various vegetables.
Compared to Cholestyramine (a cholesterol-lowering, bile acid-binding drug) that was used as the positive control treatment and cellulose as the negative control, researchers found that* Relative to cholestyramine, in vitro bile acid binding on dry matter basis was for the collard greens, kale, and mustard greens, 13%; broccoli, 10%; Brussels sprouts and spinach, 8%; green bell pepper, 7%; and cabbage, 5%.
In other words, collard greens = kale = mustard greens showed the strongest healthy-promoting potential in bile acid-binding compared to the following lesser extent of > broccoli > Brussels sprouts = spinach = green bell pepper > cabbage.
More importantly, steam cooking significantly improved the in vitro bile acid binding of collard greens, kale, mustard greens, broccoli, green bell pepper, and cabbage compared to vegetables raw (uncooked).
More precisely, the Inclusion of steam-cooked collard greens, kale, mustard greens, broccoli, green bell pepper, and cabbage in our daily diet may have the potential in improving healthy levels of blood cholesterol.
Collectively, researchers said, "These green/leafy vegetables, when consumed regularly after steam cooking, would lower the risk of cardiovascular disease and cancer, advance human nutrition research, and improve public health".
Taken altogether, green leafy veggies may be considered functional foods for lowering blood cholesterol, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Steam cooking significantly improves in vitro bile acid binding of collard greens, kale, mustard greens, broccoli, green bell pepper, and cabbage by Kahlon TS1, Chiu MC, Chapman MH. (PubMed)
#Healthyfood #Tomatoes Inhibit Parameters Associated with #Hypercholesterolemia, Researchers Suggest
Kyle J. Norton
Hypercholesterolemia is a condition of high blood cholesterol. A condition is a form of hyperlipidemia or high blood lipids.
The cause of hypercholesterolemia is a result of overexpression of low-density lipoprotein with reduced levels of high-density lipoprotein in the blood.
Believe it or not, cholesterol produced by the liver or from outside sources is essential for the building of strong cell membranes, the production of steroid hormone and vitamin D.
However, overexpression of blood cholesterol-induced hypercholesterolemia has been found to exhibit the risk of cardiovascular disease and diabetes.
Compared to hypercholesterolemia, healthy levels of LDL/HDL are any numbers that are less than 4.
There is no single cause of hypercholesterolemia. Epidemiologically, diet, obesity, genetic preposition and medical conditions such as diseases such as type 2 diabetes and an underactive thyroid are some the prevalent factors associated with the risk of the condition.
According to the statistics, over 34 million American adults are living with elevated blood cholesterol levels (higher than 240 mg/dL). ...
The most common inherited form of high blood cholesterol is called familial hypercholesterolemia found in 1/500 people.
By adopting a healthy lifestyle and moderate exercise, you may do just fine without medication.
Tomato a is red, edible fruit, genus Solanum, belongs to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a natural ingredient or whole food for the treatment of hypercholesterolemia, researchers compared the effect of dried tomato, grape and apple pomace (5% in diet) on the cholesterol levels in serum in an animal model
The study included selected male Wistar rats fed a cholesterol diet (0.3%) shortly after weaning followed by administration of individual fruits contained 47.2, 67.0 and 46.2 g of total dietary fiber per 100 g of dry matter for tomato, grape and apple pomace, respectively.
Compared to apple pomace reduced the liver cholesterol by 11% tomato showed a better-reduced cholesterol level in the liver by 15%
Tomatoes and other tested pomace species reduced cholesterol content in the heart by 18-21%.
Only tomatoes exerted a significant effect on the levels of triacylglycerol content in the heart compared to other tested pomaces.
All products strongly reduced (up to half of the original value) the activity of enzymes HMG-CoA reductase associated with the production of cholesterol in the liver and increased the fractional catabolic rate of plasma cholesterol by 60-120%.
In rats fed with hypercholesterolemic feed and treated with lycopene orally by gavage at the dose of 5, 25, 45, 65, 85, and 105, 125 mg/kg/bw-1/d-1, researchers found that injection of all doses of lycopene exerted a statistical significance in reducing the levels of cholesterol observed by inverse U shape at the 4 weeks of the experiment.
Furthermore, serum lycopene concentration was negatively correlated with the levels of serum TC, and LDL-C, particularly in the cerebral LDL-C.
In other words, serum lycopene found in the tested model showed a strong effect against brain cholesterol in facilitating neuron damage.
Dr. Wang W, the lead scientist said, "These results suggested an inverse U-shape relation between dose and serum concentration of lycopene, and intermediate doses were most effective to protect cerebral vessels and neurons from being damaged by hyperlipidemia".
Taken together, tomatoes processed with high amounts of lycopene may be considered supplements for the prevention and treatment of hypercholesterolemia, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effect of dried tomato, grape and apple pomace on the cholesterol metabolism and antioxidative enzymatic system in rats with hypercholesterolemia by Bobek P1, Ozdín L, Hromadová M. (PubMed)
(2) The dose-response effect of lycopene on the cerebral vessel and neuron impairment induced by hyperlipidemia by Wang W, Yang W, Shen Z, Wen S, Hu M. (PubMed)
Hypercholesterolemia is a condition of high blood cholesterol. A condition is a form of hyperlipidemia or high blood lipids.
The cause of hypercholesterolemia is a result of overexpression of low-density lipoprotein with reduced levels of high-density lipoprotein in the blood.
Believe it or not, cholesterol produced by the liver or from outside sources is essential for the building of strong cell membranes, the production of steroid hormone and vitamin D.
However, overexpression of blood cholesterol-induced hypercholesterolemia has been found to exhibit the risk of cardiovascular disease and diabetes.
Compared to hypercholesterolemia, healthy levels of LDL/HDL are any numbers that are less than 4.
There is no single cause of hypercholesterolemia. Epidemiologically, diet, obesity, genetic preposition and medical conditions such as diseases such as type 2 diabetes and an underactive thyroid are some the prevalent factors associated with the risk of the condition.
According to the statistics, over 34 million American adults are living with elevated blood cholesterol levels (higher than 240 mg/dL). ...
The most common inherited form of high blood cholesterol is called familial hypercholesterolemia found in 1/500 people.
By adopting a healthy lifestyle and moderate exercise, you may do just fine without medication.
Tomato a is red, edible fruit, genus Solanum, belongs to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a natural ingredient or whole food for the treatment of hypercholesterolemia, researchers compared the effect of dried tomato, grape and apple pomace (5% in diet) on the cholesterol levels in serum in an animal model
The study included selected male Wistar rats fed a cholesterol diet (0.3%) shortly after weaning followed by administration of individual fruits contained 47.2, 67.0 and 46.2 g of total dietary fiber per 100 g of dry matter for tomato, grape and apple pomace, respectively.
Compared to apple pomace reduced the liver cholesterol by 11% tomato showed a better-reduced cholesterol level in the liver by 15%
Tomatoes and other tested pomace species reduced cholesterol content in the heart by 18-21%.
Only tomatoes exerted a significant effect on the levels of triacylglycerol content in the heart compared to other tested pomaces.
All products strongly reduced (up to half of the original value) the activity of enzymes HMG-CoA reductase associated with the production of cholesterol in the liver and increased the fractional catabolic rate of plasma cholesterol by 60-120%.
In rats fed with hypercholesterolemic feed and treated with lycopene orally by gavage at the dose of 5, 25, 45, 65, 85, and 105, 125 mg/kg/bw-1/d-1, researchers found that injection of all doses of lycopene exerted a statistical significance in reducing the levels of cholesterol observed by inverse U shape at the 4 weeks of the experiment.
Furthermore, serum lycopene concentration was negatively correlated with the levels of serum TC, and LDL-C, particularly in the cerebral LDL-C.
In other words, serum lycopene found in the tested model showed a strong effect against brain cholesterol in facilitating neuron damage.
Dr. Wang W, the lead scientist said, "These results suggested an inverse U-shape relation between dose and serum concentration of lycopene, and intermediate doses were most effective to protect cerebral vessels and neurons from being damaged by hyperlipidemia".
Taken together, tomatoes processed with high amounts of lycopene may be considered supplements for the prevention and treatment of hypercholesterolemia, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effect of dried tomato, grape and apple pomace on the cholesterol metabolism and antioxidative enzymatic system in rats with hypercholesterolemia by Bobek P1, Ozdín L, Hromadová M. (PubMed)
(2) The dose-response effect of lycopene on the cerebral vessel and neuron impairment induced by hyperlipidemia by Wang W, Yang W, Shen Z, Wen S, Hu M. (PubMed)
#Cranberry#Extract #Oximacro(®) and Purified A-Type Proanthocyanidins (PACs-A) Inhibit #Herpes Simplex Virus 1 and 2 (HSV-1, 2) Infection
Kyle J. norton
Herpes simplex virus 1 (HSV-1) primarily causes oral herpes, including cold sores and fever blisters around the mouth and on the face.
Herpes simplex virus-2 (HSV-2) primarily causes genital herpes and genital herpes outbreaks
Infection can be acute or chronic. In the acute phase of infection, after receiving the messages from the central nervous system related to the danger of microbial infection, the immune macrophages in the first line of defense stimulates the production of blood palette to the cover the wound and pro-inflammatory cytokines to the site of the infection to kill off pathogens which try to enter the body.
However, overproduction of pro-inflammatory cytokines in the acute phase of infection has also killed off or damage to the nearby healthy cells, leading to the formation of scars.
In most cases in a healthy individual, the immune system can easily eradicate all foreign invaders and the wound is recovered within days and weeks.
Symptoms of the acute infection include gastrointestinal discomforts, such as congestion vomiting or nausea, diarrhea, short-term joint or muscle pain, fever, headache, skin rash, and cough, Some patients with acute infection also experience symptoms of swollen lymph nodes, an indication of the body is fighting infection.
In chronic infection, the symptoms are most vague or no specific symptoms, including bronchitis and asthma, persistent low-grade chronic joint and muscle pain, or swelling, and the alternations between diarrhea and constipation, bloating, or heartburn, In other words, the symptoms are totally depended on the location of the low-grade inflammation.
Most cases of infection except those of viral infection are treated by topical antibiotic cream and/or oral antibiotics.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of skin infection, researchers investigated the effects of cranberry (Vaccinium macrocarpon Ait.) extracts Oximacro(®) against Herpes simplex type 1 (HSV-1) and type 2 (HSV-2) infections.
In vitro, the novel cranberry inhibited HSV-1 and HSV-2 replication.
Furthermore, Oximacro(®) prevented the adsorption of HSV-1 and HSV-2 to target cells.
Moreover, Oximacro(®) and its PACs-A targeted the viral envelope glycoproteins gD and gB to enter cells, thus resulting in the loss of infectivity of HSV particles.
Most importantly, Oximacro(®) completely exerted continuously its anti-HSV activity even at acidic pHs (3.0 and 4.0) and in the presence of 10% human serum proteins, and conditions that mimic the physiological properties of the vagina.
Based on the findings, researchers said, "Oximacro(®) as an attractive candidate for the development of novel microbicides of natural origin for the prevention of HSV infections".
Taken together, cranberry may be considered an immune-modulatory remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibition of herpes simplex type 1 and type 2 infections by Oximacro(®), a cranberry extract with a high content of A-type proanthocyanidins (PACs-A) by Terlizzi ME1, Occhipinti A2, Luganini A3, Maffei ME4, Gribaudo G. (PubMed)
Herpes simplex virus 1 (HSV-1) primarily causes oral herpes, including cold sores and fever blisters around the mouth and on the face.
Herpes simplex virus-2 (HSV-2) primarily causes genital herpes and genital herpes outbreaks
Infection can be acute or chronic. In the acute phase of infection, after receiving the messages from the central nervous system related to the danger of microbial infection, the immune macrophages in the first line of defense stimulates the production of blood palette to the cover the wound and pro-inflammatory cytokines to the site of the infection to kill off pathogens which try to enter the body.
However, overproduction of pro-inflammatory cytokines in the acute phase of infection has also killed off or damage to the nearby healthy cells, leading to the formation of scars.
In most cases in a healthy individual, the immune system can easily eradicate all foreign invaders and the wound is recovered within days and weeks.
Symptoms of the acute infection include gastrointestinal discomforts, such as congestion vomiting or nausea, diarrhea, short-term joint or muscle pain, fever, headache, skin rash, and cough, Some patients with acute infection also experience symptoms of swollen lymph nodes, an indication of the body is fighting infection.
In chronic infection, the symptoms are most vague or no specific symptoms, including bronchitis and asthma, persistent low-grade chronic joint and muscle pain, or swelling, and the alternations between diarrhea and constipation, bloating, or heartburn, In other words, the symptoms are totally depended on the location of the low-grade inflammation.
Most cases of infection except those of viral infection are treated by topical antibiotic cream and/or oral antibiotics.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of skin infection, researchers investigated the effects of cranberry (Vaccinium macrocarpon Ait.) extracts Oximacro(®) against Herpes simplex type 1 (HSV-1) and type 2 (HSV-2) infections.
In vitro, the novel cranberry inhibited HSV-1 and HSV-2 replication.
Furthermore, Oximacro(®) prevented the adsorption of HSV-1 and HSV-2 to target cells.
Moreover, Oximacro(®) and its PACs-A targeted the viral envelope glycoproteins gD and gB to enter cells, thus resulting in the loss of infectivity of HSV particles.
Most importantly, Oximacro(®) completely exerted continuously its anti-HSV activity even at acidic pHs (3.0 and 4.0) and in the presence of 10% human serum proteins, and conditions that mimic the physiological properties of the vagina.
Based on the findings, researchers said, "Oximacro(®) as an attractive candidate for the development of novel microbicides of natural origin for the prevention of HSV infections".
Taken together, cranberry may be considered an immune-modulatory remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibition of herpes simplex type 1 and type 2 infections by Oximacro(®), a cranberry extract with a high content of A-type proanthocyanidins (PACs-A) by Terlizzi ME1, Occhipinti A2, Luganini A3, Maffei ME4, Gribaudo G. (PubMed)
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