Kyle J. Norton
Studies suggested that garlic may have the potential in killing bowel cancer cells before they can spread to form colonization.
Bowel cancer also known as colorectal cancer, is a chronic medical condition caused by the abnormal proliferation of cells in the colon, rectum, or vermiform appendix.
Bowel cancer is a relatively very common and slowly growing cancer. The progression of cancer is predictable.
The exact causes of bowel cancer are unknown. researchers as of today do not know why people in the same health condition and age in the same family and similar dietary patterns, are susceptible to the onset of bowel cancer, while others do not.
However, researchers do know that certain risk factors are associated with the development of the disease, including age, family history
Some researchers suggested that the mutated gene inherited from the parents, and certain medical conditions such as inflammatory bowel disease, polyps, and obesity are also some of the bowel cancer prevalent risk factors.
A recent study also showed people who smoke and consume high volumes of red meat are also at elevated risk of the onset of the disease.
Truly, following a healthy diet and active lifestyle can decrease the risk of bowel cancer by 10 folds. Dr. IAIN ROBERTSON, the lead author at Monash University, in the study "Colorectal cancer, diet, and lifestyle factors: opportunities for prevention" wrote, " The potential for colorectal cancer risk reduction by decreasing consumption of animal fats, red meat, alcohol, and cigarettes, by increasing physical activity levels, and by increasing intake of fruits, vegetables, and dietary fiber".
If you are experiencing symptoms of a change of bowel habits that last longer than one month, persistent rectal bleeding, abdominal pain that does not stop,.and blood in the stool, please check with your doctor to rule out the possibility of bowel cancer.
Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia.
The pungent spice has been used popularly in traditional and Chinese medicine in treating the common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.
Allicin (diallyl thiosulfinate), is the best-known biologically active component in freshly crushed garlic, found to reduce the risk of bowel cancer through inhibiting bowel cancer cell lines HCT-116, LS174T, HT-29, and Caco-2, via the activity of Nrf2, according to The Hebrew University of Jerusalem.
Nrf2 is a protein that regulates the expression of antioxidant proteins to protect the cells against damage and injury caused by oxidative stress triggered by inflammation.
However, in the colon cancer cell lines, overexpression of Nsf2 can initiate cancer cell apoptosis.
The Chungbuk National University study that uses colon cancer cells (SW620 and HCT116) to investigate whether sulfur compounds thiacremonone isolated from garlic could modulate NF-kappaB activity and thereby induce apoptotic cell death of colon cancer cells, suggested, the application of different concentrations ranging from 30 - 150 microg/ml of thiacremonone for the periods from 0 to 48 hour inhibited colon cancer cell (SW620 and HCT116) growth followed by induction of apoptosis in a dose-dependent manner.
Further analysis showed that the efficacy of the novel sulfur compound against colon cancer cell growth and induction of apoptotic cell death was attributed to the compound's function in modulating NF-kappaB, a protein that controls transcription of DNA, cytokine production, and cell survival.
In vitro, intake of garlic and its lipid-based extracts, induced cell cycle arrest, through a fourfold increase in caspase activity (apoptosis) in PC-3 cells when treated at a dose of 0.5 or 1 μg/m and may be considered a potential as promising anticancer agents, including colon cancer.
Dr. Baena R and Dr, Salinas P said, " Dietary factors and lifestyle may contribute to the increasing colorectal cancer (CRC) incidence... Fish consumption may decrease CRC risk by 12% whereas garlic intake is not significantly associated with reduced CRC risk".
In fact, diet represents 30-35% of risk factors that contribute to the onset of cancer, adding garlic in your diet together with the reduction of meat intake can reduce the risk of various cancers, including colorectal cancer
However, in order to confirm garlic isolated compounds' anti bowel cancer efficacy, further data collection on large example size and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2 by Bat-Chen W1, Golan T, Peri I, Ludmer Z, Schwartz B.(PubMed)
(2) Inhibition of cell growth and induction of apoptosis via inactivation of NF-kappaB by a sulfur compound isolated from garlic in human colon cancer cells by Ban JO1, Yuk DY, Woo KS, Kim TM, Lee US, Jeong HS, Kim DJ, Chung YB, Hwang BY, Oh KW, Hong JT. (PubMed)
(3) Crude Garlic Extract Inhibits Cell Proliferation and Induces Cell Cycle Arrest and Apoptosis of Cancer Cells In Vitro by Bagul M1, Kakumanu S1, Wilson TA1,2. (PubMed)
(4) Diet and colorectal cancer by Baena R1, Salinas P2(PubMed)
(5) Diet and cancer: risk factors and epidemiological evidence by Baena Ruiz R1, Salinas Hernández P2.(PubMed)
(6) Colorectal cancer, diet, and lifestyle factors: opportunities for prevention by IAIN ROBERTSON, RONA BOUND and LEONIE SEGAL, (Monash University)
Monday 31 July 2023
Extracts from #GymnemaLeave and Cinnamomum Bark Inhibit #CervicalCancer by Inducing Cytotoxicity, and Apoptosis, According to Studies
Kyle J. Norton
Cinnamon may be the Best Wholefood Medicine for Prevention, management, and Treatment of Cervical Cancer. According to the Manipal University, Eugenol, a potential chemopreventive agent, one of the components of cinnamon possesses antiseptic, analgesic, antibacterial, and anticancer properties in the expression of apoptosis and inflammation against cervical cancer cell lines.
Cinnamon is a spice derived from the inner bark of tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the familyLauraceae, use in herbal and traditional medicine as anti-fungal and bacterial levels, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.
In the SiHa cancer cell line, established from cancerous tissues of the cervix uteri, methanol extracts of Gymnema sylvestre (GS) leave and Cinnamomum zeylanicum (CZ) bark exhibited dose-dependent cytotoxicity, inducing apoptosis.
Other researchers suggested that the effective use of cinnamon against tumor activity, particularly in cervical cancer cell line SiHa may result in a reduced number of colonies, risk of migration potential through down-regulated normal physiological processes.
Dr. Kwon HK, the lead researcher at the Gwangju Institute of Science and Technology, insisted, Cinnamomum cassia bark,.. containing several active components such as essential oils, expressed anti-tumor effect via enhanced pro-apoptotic and inhibition of pro-inflammatory activities, in vitro, and in vivo mouse melanoma model.
In fact, the potential anti-tumor effects of cinnamon may be due to increased anti-tumor activities in the suppression of progression by increasing the levels of cytolytic molecules and cytotoxic activity.
Although the whole herb medicine may be a potential agent for reduced risk and treatment of cervical cancer, oral use of cinnamon should be taken with care and only prescribed by an herbalist.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Sources
(1) Eugenol enhances the chemotherapeutic potential of gemcitabine and induces anticarcinogenic and anti-inflammatory activity in human cervical cancer cells by Hussain A1, Brahmbhatt K, Priyani A, Ahmed M, Rizvi TA, Sharma C.(PubMed)
(2) Biomolecule-loaded chitosan nanoparticles induce apoptosis and molecular changes in cancer cell line (SiHa) by Sujima Anbu A1, Velmurugan P2, Lee JH3, Oh BT4, Venkatachalam P5. (PubMed)
(3) Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in a human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential by Koppikar SJ1, Choudhari AS, Suryavanshi SA, Kumari S, Chattopadhyay S, Kaul-Ghanekar R.(PubMed)
(4) Cinnamon extract induces tumor cell death through inhibition of NFkappaB and AP1 by Kwon HK1, Hwang JS, So JS, Lee CG, Sahoo A, Ryu JH, Jeon WK, Ko BS, Im CR, Lee SH, Park ZY, Im SH. (PubMed)
(5) Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells by Kwon HK1, Jeon WK, Hwang JS, Lee CG, So JS, Park JA, Ko BS, Im SH. (PubMed)
Cinnamon may be the Best Wholefood Medicine for Prevention, management, and Treatment of Cervical Cancer. According to the Manipal University, Eugenol, a potential chemopreventive agent, one of the components of cinnamon possesses antiseptic, analgesic, antibacterial, and anticancer properties in the expression of apoptosis and inflammation against cervical cancer cell lines.
Cinnamon is a spice derived from the inner bark of tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the familyLauraceae, use in herbal and traditional medicine as anti-fungal and bacterial levels, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.
In the SiHa cancer cell line, established from cancerous tissues of the cervix uteri, methanol extracts of Gymnema sylvestre (GS) leave and Cinnamomum zeylanicum (CZ) bark exhibited dose-dependent cytotoxicity, inducing apoptosis.
Other researchers suggested that the effective use of cinnamon against tumor activity, particularly in cervical cancer cell line SiHa may result in a reduced number of colonies, risk of migration potential through down-regulated normal physiological processes.
Dr. Kwon HK, the lead researcher at the Gwangju Institute of Science and Technology, insisted, Cinnamomum cassia bark,.. containing several active components such as essential oils, expressed anti-tumor effect via enhanced pro-apoptotic and inhibition of pro-inflammatory activities, in vitro, and in vivo mouse melanoma model.
In fact, the potential anti-tumor effects of cinnamon may be due to increased anti-tumor activities in the suppression of progression by increasing the levels of cytolytic molecules and cytotoxic activity.
Although the whole herb medicine may be a potential agent for reduced risk and treatment of cervical cancer, oral use of cinnamon should be taken with care and only prescribed by an herbalist.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Sources
(1) Eugenol enhances the chemotherapeutic potential of gemcitabine and induces anticarcinogenic and anti-inflammatory activity in human cervical cancer cells by Hussain A1, Brahmbhatt K, Priyani A, Ahmed M, Rizvi TA, Sharma C.(PubMed)
(2) Biomolecule-loaded chitosan nanoparticles induce apoptosis and molecular changes in cancer cell line (SiHa) by Sujima Anbu A1, Velmurugan P2, Lee JH3, Oh BT4, Venkatachalam P5. (PubMed)
(3) Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in a human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential by Koppikar SJ1, Choudhari AS, Suryavanshi SA, Kumari S, Chattopadhyay S, Kaul-Ghanekar R.(PubMed)
(4) Cinnamon extract induces tumor cell death through inhibition of NFkappaB and AP1 by Kwon HK1, Hwang JS, So JS, Lee CG, Sahoo A, Ryu JH, Jeon WK, Ko BS, Im CR, Lee SH, Park ZY, Im SH. (PubMed)
(5) Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells by Kwon HK1, Jeon WK, Hwang JS, Lee CG, So JS, Park JA, Ko BS, Im SH. (PubMed)
#RapeseedOil Inhibits The Clusters of Metabolic Syndrome Associated with CardiovascularDisease and Non Fatty #LiverDiseases
Kyle J. Norton
Metabolic syndrome is a cluster of conditions associated with the increased risk of cardiovascular disease and diabetes.
The health problems found in the group include too much fat around the waist, elevated blood pressure, high triglycerides, elevated blood sugar, and low HDL cholesterol.
In other words, if you have 3 of the conditions in the group, your risk of CVD and diabetes are increased substantially compared to those who have less.
According to the statistics, approximately 30% of people in the US are living with metabolic syndrome.
Believe it or not, among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 1988–1994 to 2007–2012, increasing from 25.3% to 34.2%.
Rapeseed, also known as rape, or oilseed rape, is a member of the family Brassicaceae (mustard or cabbage family), cultivated in suitable climate regions for its oil-rich seed for commercial profits.
To find a potential compound for the prevention of heart disease, researchers at the University of Applied Sciences investigated the effects of a hypo energetic diet with low energy density (ED) enriched in rapeseed oil-derived n-3 fatty acid α-linolenic acid (ALA), in patients with metabolic syndrome.
The human trial included eighty-one patients with metabolic syndrome randomly assigned to receive either rapeseed oil derived with high MUFA content and an ALA intake of 3.5 g/d on body weight or olive oil diet rich in MUFA but with a low ALA content.
According to the results, after a 6-month dietary intervention, the rapeseed oil and olive oil groups showed a significant in reduced body weight and metabolic factors associated with cardiovascular risk.
In other words, intervention groups with rapeseed oil not only significantly decrease the systolic blood pressure, but also reduce total cholesterol and LDL-cholesterol, and insulin levels in patients with metabolic syndrome.
More interestingly, serum triglycerides (TAG) associated with cardiovascular and nonfatty liver disease risk factors were significantly reduced only in the high ALA intake, compared to no effect on the low ALA group.
Based on the findings, researchers said, "Our dietary food pattern with a low ED and high intakes of MUFA and ALA may be a practical approach for long-term dietary treatment in patients with the metabolic syndrome".
Taken altogether, rapeseed oil may be considered a supplement for the prevention and treatment of metabolic syndrome, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of a rapeseed oil-enriched hypo energetic diet with a high content of α-linolenic acid on body weight and cardiovascular risk profile in patients with the metabolic syndrome by Baxheinrich A1, Stratmann B, Lee-Barkey YH, Tschoepe D, Wahrburg U. (PubMed)
Metabolic syndrome is a cluster of conditions associated with the increased risk of cardiovascular disease and diabetes.
The health problems found in the group include too much fat around the waist, elevated blood pressure, high triglycerides, elevated blood sugar, and low HDL cholesterol.
In other words, if you have 3 of the conditions in the group, your risk of CVD and diabetes are increased substantially compared to those who have less.
According to the statistics, approximately 30% of people in the US are living with metabolic syndrome.
Believe it or not, among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 1988–1994 to 2007–2012, increasing from 25.3% to 34.2%.
Rapeseed, also known as rape, or oilseed rape, is a member of the family Brassicaceae (mustard or cabbage family), cultivated in suitable climate regions for its oil-rich seed for commercial profits.
To find a potential compound for the prevention of heart disease, researchers at the University of Applied Sciences investigated the effects of a hypo energetic diet with low energy density (ED) enriched in rapeseed oil-derived n-3 fatty acid α-linolenic acid (ALA), in patients with metabolic syndrome.
The human trial included eighty-one patients with metabolic syndrome randomly assigned to receive either rapeseed oil derived with high MUFA content and an ALA intake of 3.5 g/d on body weight or olive oil diet rich in MUFA but with a low ALA content.
According to the results, after a 6-month dietary intervention, the rapeseed oil and olive oil groups showed a significant in reduced body weight and metabolic factors associated with cardiovascular risk.
In other words, intervention groups with rapeseed oil not only significantly decrease the systolic blood pressure, but also reduce total cholesterol and LDL-cholesterol, and insulin levels in patients with metabolic syndrome.
More interestingly, serum triglycerides (TAG) associated with cardiovascular and nonfatty liver disease risk factors were significantly reduced only in the high ALA intake, compared to no effect on the low ALA group.
Based on the findings, researchers said, "Our dietary food pattern with a low ED and high intakes of MUFA and ALA may be a practical approach for long-term dietary treatment in patients with the metabolic syndrome".
Taken altogether, rapeseed oil may be considered a supplement for the prevention and treatment of metabolic syndrome, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of a rapeseed oil-enriched hypo energetic diet with a high content of α-linolenic acid on body weight and cardiovascular risk profile in patients with the metabolic syndrome by Baxheinrich A1, Stratmann B, Lee-Barkey YH, Tschoepe D, Wahrburg U. (PubMed)
#Strawberries Inhibit Parameter Inflammatory Expression Against the Onset of Type 2 #Diabetes, According to Studies
Kyle J. Norton
The rise of obesity associated with the increase in the incidence of Type 2 diabetes has been a significant burden on healthcare systems in many countries.
Strawberry processed abundant phytochemicals may be the next target for pharmaceutical companies to extract a single ingredient for the treatment of type 2 diabetes, some scientists suggested.
Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose as the result of either cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
Researchers do not why people with similar health conditions, diet, and family history are susceptible to the development of insulin resistance, the early stage of diabetes while others do.
Some researchers suggested that genetic proposition and unhealthy lifestyle accompanied by physical activity are the most common risk factors associated with the onset of type 2 diabetes.
Dr. Karla C. Paz-Salinas, the lead author in the study "Do People with Type 2 Diabetes Think They are Unhealthy?" wrote, "A healthy lifestyle and understanding of diabetes management are important factors for delaying the onset of comorbidities associated with Type 2 diabetes".
In genetic preposition front, researchers at the Medical College of Wisconsin, said, "Very few T2D risk genes were identified using candidate gene and linkage-based studies, but the advent of genome-wide association studies has led to the identification of multiple genes, including several that were not previously known to play any role in T2D. Highly genes, for example, TCF7L2, KCNQ1, and KCNJ11 are discussed in greater detail".
We can not prevent the onset of type 2 diabetes caused by a genetic mutation, however, the risk of type 2 diabetes can be reduced substantially and type 2 diabetes can be easily managed if we are following the healthy lifestyle that processes the diet high in fruits and vegetable, less in saturated and trans fat, red meat and processed food with moderate exercise.
Strawberry is a genius of Fragaria × ananassa and belongs to the family Rosaceae. They have been grown all over the world with a suitable climate for commercial profits and for health benefits.
The major chemical compounds of strawberry include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.
In the finding of a natural ingredient for the treatment of diabetes with no side effects, researchers at the University of California launched a study to examine the anti-inflammatory and blood glucose (BG)-regulating the capacity of strawberries in a mouse model of diet-induced obesity.
In a total of thirty-six male C57BL/6J mice were included in the study randomly divided into four groups (nine mice per group), including mice fed a low-fat diet (LF, 13 % fat), the LF supplemented with 2·6 % freeze-dried strawberry powder (LFSB), a high-fat diet (HF, 44 % fat) or the HF supplemented with 2·6 % strawberry powder (HFSB).
The dietary intake of SB approximated one human serving of strawberries
Before the administration of strawberry powder, a blood sample of HF group showed an increased non-fasted BG, insulin, soluble intracellular adhesion molecule-1, the important biomarkers for inflammatory processes involving activation or damage to cells, E-selectin, leptin, resistin, and plasminogen activator protein-1, the indication of the inflammatory process.
High dietary fat decreased IL-4 production, an anti-inflammatory cytokine from activated splenocytes, the white blood cells.
The levels of BG concentrations were lower in the mice supplemented with SB (10·64 mmol/l) compared to the non-supplemented mice.
BG values were approximately 6·5 % lower in the supplemented mice.
These results firmly supported a promising role for dietary strawberries in reducing the risks associated with obesity and diabetes and regulating the levels of inflammatory markers in non-obese individuals.
The study was published Nov 28 in the US National Library of Medicine and National Institutes of Health. You can view the abstract by clicking the link in the resources box.
Please note that strawberry contains a measured amount of oxalates, if you have kidney disease, please check with your doctor before applying.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Dietary strawberry powder reduces blood glucose concentrations in obese and lean C57BL/6 mice and selectively lowers plasma C-reactive protein in lean mice by Parelman MA, Storms DH, Kirschke CP, Huang L, Zunino SJ. (PubMed)
(2) Do People with Type 2 Diabetes Think They are Unhealthy? by A Cross-Sectional Study in Celaya, Mexico by Karla C. Paz-Salinas,1 Nicolas Padilla-Raygoza,1,2 Silvia C. Delgado-Sandoval,1,2Georgina Olvera-Villanueva,1,2 and Ma Laura Ruiz-Paloalto. (PMC)
The rise of obesity associated with the increase in the incidence of Type 2 diabetes has been a significant burden on healthcare systems in many countries.
Strawberry processed abundant phytochemicals may be the next target for pharmaceutical companies to extract a single ingredient for the treatment of type 2 diabetes, some scientists suggested.
Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose as the result of either cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
Researchers do not why people with similar health conditions, diet, and family history are susceptible to the development of insulin resistance, the early stage of diabetes while others do.
Some researchers suggested that genetic proposition and unhealthy lifestyle accompanied by physical activity are the most common risk factors associated with the onset of type 2 diabetes.
Dr. Karla C. Paz-Salinas, the lead author in the study "Do People with Type 2 Diabetes Think They are Unhealthy?" wrote, "A healthy lifestyle and understanding of diabetes management are important factors for delaying the onset of comorbidities associated with Type 2 diabetes".
In genetic preposition front, researchers at the Medical College of Wisconsin, said, "Very few T2D risk genes were identified using candidate gene and linkage-based studies, but the advent of genome-wide association studies has led to the identification of multiple genes, including several that were not previously known to play any role in T2D. Highly genes, for example, TCF7L2, KCNQ1, and KCNJ11 are discussed in greater detail".
We can not prevent the onset of type 2 diabetes caused by a genetic mutation, however, the risk of type 2 diabetes can be reduced substantially and type 2 diabetes can be easily managed if we are following the healthy lifestyle that processes the diet high in fruits and vegetable, less in saturated and trans fat, red meat and processed food with moderate exercise.
Strawberry is a genius of Fragaria × ananassa and belongs to the family Rosaceae. They have been grown all over the world with a suitable climate for commercial profits and for health benefits.
The major chemical compounds of strawberry include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.
In the finding of a natural ingredient for the treatment of diabetes with no side effects, researchers at the University of California launched a study to examine the anti-inflammatory and blood glucose (BG)-regulating the capacity of strawberries in a mouse model of diet-induced obesity.
In a total of thirty-six male C57BL/6J mice were included in the study randomly divided into four groups (nine mice per group), including mice fed a low-fat diet (LF, 13 % fat), the LF supplemented with 2·6 % freeze-dried strawberry powder (LFSB), a high-fat diet (HF, 44 % fat) or the HF supplemented with 2·6 % strawberry powder (HFSB).
The dietary intake of SB approximated one human serving of strawberries
Before the administration of strawberry powder, a blood sample of HF group showed an increased non-fasted BG, insulin, soluble intracellular adhesion molecule-1, the important biomarkers for inflammatory processes involving activation or damage to cells, E-selectin, leptin, resistin, and plasminogen activator protein-1, the indication of the inflammatory process.
High dietary fat decreased IL-4 production, an anti-inflammatory cytokine from activated splenocytes, the white blood cells.
The levels of BG concentrations were lower in the mice supplemented with SB (10·64 mmol/l) compared to the non-supplemented mice.
BG values were approximately 6·5 % lower in the supplemented mice.
These results firmly supported a promising role for dietary strawberries in reducing the risks associated with obesity and diabetes and regulating the levels of inflammatory markers in non-obese individuals.
The study was published Nov 28 in the US National Library of Medicine and National Institutes of Health. You can view the abstract by clicking the link in the resources box.
Please note that strawberry contains a measured amount of oxalates, if you have kidney disease, please check with your doctor before applying.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Dietary strawberry powder reduces blood glucose concentrations in obese and lean C57BL/6 mice and selectively lowers plasma C-reactive protein in lean mice by Parelman MA, Storms DH, Kirschke CP, Huang L, Zunino SJ. (PubMed)
(2) Do People with Type 2 Diabetes Think They are Unhealthy? by A Cross-Sectional Study in Celaya, Mexico by Karla C. Paz-Salinas,1 Nicolas Padilla-Raygoza,1,2 Silvia C. Delgado-Sandoval,1,2Georgina Olvera-Villanueva,1,2 and Ma Laura Ruiz-Paloalto. (PMC)
#Healthyfood #Onion Inhibits #Vascular #ndothelial Dysfunction Against the Risk of #CardiovascularDisease, Scientists Suggest
Kyle J. Norton
Vasoprotection is the process to improve the function of the blood vessels, including the use of herbal and natural remedies.
Blood vessels are the tubular structure including a vein, artery, or capillary which carries the blood through the tissues and organs pumped by the heart.
There 3 main types of the blood vessel are arteries that deliver oxygen-rich blood from the heart to the tissues and organs of the body. Damage of arteries may induce coronary artery disease associated with the narrowing or blockage of the coronary arteries due to plaques accumulated on the arterial wall.
The veins that carry blood toward the heart. Chronic venous insufficiency (CVI) is a common condition associated with a disease of the veins that affects up to 20 percent of adults.
The capillaries or the smallest blood vessels have been found to induce systemic capillary leak syndrome (SCLS) is a rare acquired disorder.
Endothelial dysfunction is a condition characterized by the damage of the vascular endothelium, the thin layer of cells that lines blood vessels, a leading cause of the cardiovascular disease (CVD).
In other words, vascular endothelium dysfunction reduced the function of targeting free radicals that lead to the onset of oxidative stress.
The most common risk factors associated with vascular endothelium dysfunction are impaired vasodilation, deficiency of nitric oxide, inflammation, and thrombosis.
Dr. Hirata Y. at The University of Tokyo.wrote, "Vascular endothelial dysfunction reflected by reduced nitric oxide (NO) availability is certainly the causative factor or promoting mechanism of arteriosclerosis. It is necessary to detect endothelial dysfunction at an early stage using appropriate methods, and to choose a treatment for the recovery of endothelial function".
And, "There are nonpharmacological and pharmacological therapies to attain endothelial repair. The former includes bodyweight reduction, aerobic exercise, and restriction of salt intake, while the latter includes the use of renin-angiotensin system inhibitors, calcium antagonists, some types of beta-blockers, statins, erythropoietin, tetrahydrobiopterin, and antioxidants".
The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
On finding a potent ingredient which processes vasoprotective activity researchers examined quercetin, a dietary polyphenol found abundantly in onion on vascular endothelial dysfunction (VED).
Epidemiologically, quercetin showed significant activity against the VED complication in the induction of oxidative stress, impaired vasodilation, platelet aggregation, and monocyte adhesion leading to the early event of morbidity and mortality in patients with cardiovascular disease (CVD).
Quercetin efficacy which protects against VED and decreases CVD risk was attributed to its antioxidant, vasodilatory, anti-platelet, and anti-atherogenic activities.
Futhermore, in vitro, quercetin exerted multiple actions on the NO-guanylyl cyclase pathway associated with the smooth muscle tone in bronchi or vessels, endothelium-derived hyperpolarizing factor(s) and endothelin-1 involved in vasoconstriction and endothelial function.
Moreover, the phytochemical also protected endothelial cells against apoptosis.
In vivo, quercetin prevented endothelial dysfunction by reducing blood pressure, oxidative stress and end-organ damage in hypertensive animals.
In other words, regular intake of quercetin improves the endothelium functioning against the risk of VED inducing cardiovascular disease, particularly in patients with hypertension and ischemic heart disease.
Taken together, onion processed with a higher amount of quercetin may be considered a remedy for the prevention and treatment of vascular endothelial dysfunction, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Vasoprotective activities of quercetin by Richard S Bruno. (Research Gate)
(2) Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols by Perez-Vizcaino F1, Duarte J, Andriantsitohaina R. (PubMed)
(3) Diagnosis and treatment of endothelial dysfunction in cardiovascular disease by Hirata Y1, Nagata D, Suzuki E, Nishimatsu H, Suzuki J, Nagai R. (PubMed)
Vasoprotection is the process to improve the function of the blood vessels, including the use of herbal and natural remedies.
Blood vessels are the tubular structure including a vein, artery, or capillary which carries the blood through the tissues and organs pumped by the heart.
There 3 main types of the blood vessel are arteries that deliver oxygen-rich blood from the heart to the tissues and organs of the body. Damage of arteries may induce coronary artery disease associated with the narrowing or blockage of the coronary arteries due to plaques accumulated on the arterial wall.
The veins that carry blood toward the heart. Chronic venous insufficiency (CVI) is a common condition associated with a disease of the veins that affects up to 20 percent of adults.
The capillaries or the smallest blood vessels have been found to induce systemic capillary leak syndrome (SCLS) is a rare acquired disorder.
Endothelial dysfunction is a condition characterized by the damage of the vascular endothelium, the thin layer of cells that lines blood vessels, a leading cause of the cardiovascular disease (CVD).
In other words, vascular endothelium dysfunction reduced the function of targeting free radicals that lead to the onset of oxidative stress.
The most common risk factors associated with vascular endothelium dysfunction are impaired vasodilation, deficiency of nitric oxide, inflammation, and thrombosis.
Dr. Hirata Y. at The University of Tokyo.wrote, "Vascular endothelial dysfunction reflected by reduced nitric oxide (NO) availability is certainly the causative factor or promoting mechanism of arteriosclerosis. It is necessary to detect endothelial dysfunction at an early stage using appropriate methods, and to choose a treatment for the recovery of endothelial function".
And, "There are nonpharmacological and pharmacological therapies to attain endothelial repair. The former includes bodyweight reduction, aerobic exercise, and restriction of salt intake, while the latter includes the use of renin-angiotensin system inhibitors, calcium antagonists, some types of beta-blockers, statins, erythropoietin, tetrahydrobiopterin, and antioxidants".
The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
On finding a potent ingredient which processes vasoprotective activity researchers examined quercetin, a dietary polyphenol found abundantly in onion on vascular endothelial dysfunction (VED).
Epidemiologically, quercetin showed significant activity against the VED complication in the induction of oxidative stress, impaired vasodilation, platelet aggregation, and monocyte adhesion leading to the early event of morbidity and mortality in patients with cardiovascular disease (CVD).
Quercetin efficacy which protects against VED and decreases CVD risk was attributed to its antioxidant, vasodilatory, anti-platelet, and anti-atherogenic activities.
Futhermore, in vitro, quercetin exerted multiple actions on the NO-guanylyl cyclase pathway associated with the smooth muscle tone in bronchi or vessels, endothelium-derived hyperpolarizing factor(s) and endothelin-1 involved in vasoconstriction and endothelial function.
Moreover, the phytochemical also protected endothelial cells against apoptosis.
In vivo, quercetin prevented endothelial dysfunction by reducing blood pressure, oxidative stress and end-organ damage in hypertensive animals.
In other words, regular intake of quercetin improves the endothelium functioning against the risk of VED inducing cardiovascular disease, particularly in patients with hypertension and ischemic heart disease.
Taken together, onion processed with a higher amount of quercetin may be considered a remedy for the prevention and treatment of vascular endothelial dysfunction, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Vasoprotective activities of quercetin by Richard S Bruno. (Research Gate)
(2) Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols by Perez-Vizcaino F1, Duarte J, Andriantsitohaina R. (PubMed)
(3) Diagnosis and treatment of endothelial dysfunction in cardiovascular disease by Hirata Y1, Nagata D, Suzuki E, Nishimatsu H, Suzuki J, Nagai R. (PubMed)
#Herbal #Cleaver inhibits Pathways Associated with #Melanoma Cell Metastasis in Vitro, Researchers Say
Kyle J. Norton
Skin melanoma is a skin cancer characterized by the alternation of the pigment-containing cells known as melanocytes. However, in rare cases, melanoma can also occur in the mouth, intestines, or eye.
Most cases of melanoma start in melanocytes on skin before spreading to the nearby tissue. In the advanced stage, the cancer cells can also travel a distance away from the originated site to infect other tissues and organs, leading to secondary metastasis, through the circulation of blood and fluids.
The most common sites of melanoma metastasis are the lung and breast.
The most common symptoms are visible by examing the change of skin, including the sores that can not heal itself, redness or swelling, persistent itching, tenderness and pain and particular, change of skin color and bleeding off of a mole compared to the normal moles.
The 4 most common types of skin melanoma include
* Superficial spreading melanoma, the type of cancer has a tendency to spread grow outward and spread across the surface of the skin, accounted for 70% of all melanoma skin cancer.
* Nodular melanoma normally grows down into the skin and has a tendency to spread more quickly than other types of melanoma skin cancer.
* Lentigo malignant melanoma, most common in the older population, makes up approximately 15% of all melanoma skin cancer.
* Acral lentiginous melanoma, most common in people with darker skin. Cancer first moves outward before spreading deeper into the skin.
According to the statistics provided by the American Cancer Society, in 2019, approximately, 96,480 new melanomas will be diagnosed (about 57,220 in men and 39,260 in women) in the US. The condition also causes the death of 4,740 men and 2,490 women.
Believe it or not. most cases of melanoma are found in older adults. The average age diagnosed with melanoma is 63.
Cleaver is a herbaceous annual plant, genus Galium, belonging to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.
In finding a potential compound for the treatment of skin diseases, researchers investigated the Gallic acid (GA) found in herbal Cleaver in the inhibition of the growth of human cancer cells in vitro and in vivo.
GA decreases the expression of MMPs MMPs mRNA levels in A375.S2 human melanoma cells in stimulating the cancer cell metastasis.
Furthermore, GA processed antimetastatic potential by decreasing the invasiveness of cancer cells.
Moreover, this action of GA was involved in the Ras, p-ERK signaling pathways with the function to communicate a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell to induce the inhibition of MMP-2 associated with cancer spreading in A375.S2 human melanoma cells.
Based on the findings, researchers said, " These data, therefore, provide evidence for the role of GA as a potential cancer chemotherapeutic agent, which can markedly inhibit the invasive capacity of melanoma cells".
o
Taken altogether, Comfrey may be considered a remedy to inhibit cancer call spreading, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Gallic acid inhibits the migration and invasion of A375.S2 human melanoma cells through the inhibition of matrix metalloproteinase-2 and Ras by Lo C1, Lai TY, Yang JS, Yang JH, Ma YS, Weng SW, Lin HY, Chen HY, Lin JG, Chung JG. (PubMed)
Skin melanoma is a skin cancer characterized by the alternation of the pigment-containing cells known as melanocytes. However, in rare cases, melanoma can also occur in the mouth, intestines, or eye.
Most cases of melanoma start in melanocytes on skin before spreading to the nearby tissue. In the advanced stage, the cancer cells can also travel a distance away from the originated site to infect other tissues and organs, leading to secondary metastasis, through the circulation of blood and fluids.
The most common sites of melanoma metastasis are the lung and breast.
The most common symptoms are visible by examing the change of skin, including the sores that can not heal itself, redness or swelling, persistent itching, tenderness and pain and particular, change of skin color and bleeding off of a mole compared to the normal moles.
The 4 most common types of skin melanoma include
* Superficial spreading melanoma, the type of cancer has a tendency to spread grow outward and spread across the surface of the skin, accounted for 70% of all melanoma skin cancer.
* Nodular melanoma normally grows down into the skin and has a tendency to spread more quickly than other types of melanoma skin cancer.
* Lentigo malignant melanoma, most common in the older population, makes up approximately 15% of all melanoma skin cancer.
* Acral lentiginous melanoma, most common in people with darker skin. Cancer first moves outward before spreading deeper into the skin.
According to the statistics provided by the American Cancer Society, in 2019, approximately, 96,480 new melanomas will be diagnosed (about 57,220 in men and 39,260 in women) in the US. The condition also causes the death of 4,740 men and 2,490 women.
Believe it or not. most cases of melanoma are found in older adults. The average age diagnosed with melanoma is 63.
Cleaver is a herbaceous annual plant, genus Galium, belonging to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.
In finding a potential compound for the treatment of skin diseases, researchers investigated the Gallic acid (GA) found in herbal Cleaver in the inhibition of the growth of human cancer cells in vitro and in vivo.
GA decreases the expression of MMPs MMPs mRNA levels in A375.S2 human melanoma cells in stimulating the cancer cell metastasis.
Furthermore, GA processed antimetastatic potential by decreasing the invasiveness of cancer cells.
Moreover, this action of GA was involved in the Ras, p-ERK signaling pathways with the function to communicate a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell to induce the inhibition of MMP-2 associated with cancer spreading in A375.S2 human melanoma cells.
Based on the findings, researchers said, " These data, therefore, provide evidence for the role of GA as a potential cancer chemotherapeutic agent, which can markedly inhibit the invasive capacity of melanoma cells".
o
Taken altogether, Comfrey may be considered a remedy to inhibit cancer call spreading, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Gallic acid inhibits the migration and invasion of A375.S2 human melanoma cells through the inhibition of matrix metalloproteinase-2 and Ras by Lo C1, Lai TY, Yang JS, Yang JH, Ma YS, Weng SW, Lin HY, Chen HY, Lin JG, Chung JG. (PubMed)
#Omega-3 Fatty Acid's #Omegaven Combined with Chemo-Drugs Exerts A Significant Effect on #AdvancedEsophagogastricCancer
Kyle J. Norton
Cancer is a class of diseases characterized by cell growth and multiplied disorderly and uncontrollably. In the advanced stage, cancerous cells from the originated site can travel a distance away to infect other healthy tissue via lymph or blood circulation.
Most cancers process a high survival rate if they are diagnosed early. According to the Mayo Clinic, over 56 percent of people diagnosed with early-stage lung cancer live for at least five years after diagnosis. However, the five-year survival rate for people diagnosed with late-stage of invasive lung cancer is 5 %.
According to the statistic on Canadian cancer provided by the government, in 2017, there were over 200,000 newly diagnosed cancer and 80,000 Canadians died from cancer. 1 in 2 Canadians will be diagnosed with cancer, and 1 in 4 will die from the disease, during their lifetime.
The exact cause of cancers is unknown. Researchers do not know why some people without gene mutation are susceptible to early onset of cancer while others do not
However, researchers do know that certain risk factors such as aging, tobacco, sun exposure, radiation exposure, chemicals, and other substances, some viruses and bacteria, certain hormones, family history of cancer, alcohol, poor diet, and physical inactivity are associated to gene change in the initiation of cancer development.
Most cancers share the common symptoms of tiredness, unexplained weight loss, loss of appetite, and fatigue. In the advanced stage, cancer patients may also experience additional common symptoms of dehydration, nausea and vomiting, constipation, and persistent pain.
Gastroesophageal adenocarcinoma is a rare type of cancer of the esophagus, the tube that connects your mouth and stomach.
The most common risk factors associated with the onset of esophagogastric adenocarcinoma are
* Having gastroesophageal reflux disease (GERD)
* Smoking.
* Having precancerous changes in the cells of the esophagus (Barrett's esophagus)
* Being obese.
* Excessive alcohol drinking
* Frequent bile reflux.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
In finding a potential phytochemical for the treatment of cancer, researchers investigated the effects of omega-3 fatty acids in patients with advanced esophagogastric adenocarcinoma.
The study included 20 participants with advanced esophagogastric adenocarcinoma enrolled in phase II single-arm clinical trial of palliative chemotherapy (epirubicin, oxaliplatin, and capecitabine; EOX) coupled with the weekly infusion of Omegaven®.
According to the results of radiological responses,
* Partial response (EOX plus omega-3 group 73% vs. EOX alone 39%, p=0.03).
*Stable disease (EOX plus omega-3 21% vs. EOX alone 39%, p=0.24), and
* Progressive disease (EOX plus omega-3 7% vs. EOX alone 18%, p=0.34).
Most importantly, grade 3 or 4 toxicity was less common (thromboembolism & gastrointestinal) and the concentrations of pro-inflammatory proteins such as IL-2 (p=0.009), TNF-α (p<0.0001), and VEGF (p=0.002) was reduced. in those who received EOX plus omega-3.
Based on the evidence, researchers said, "The treatment with supplementary omega-3 fatty acids reduced chemotherapy-related toxicity and resulted in better radiological responses".
Taken together, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered an adjunct therapy in the treatment of advanced esophagogastric adenocarcinoma, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The Effect of Supplementary Omegaven® on the Clinical Outcome of Patients With Advanced Esophagogastric Adenocarcinoma Receiving Palliative Epirubicin, Oxaliplatin, and Capecitabine Chemotherapy: A Phase II clinical trial by Eltweri AM1, Thomas AL2, Chung WY3, Morgan B3, Thompson J4, Dennison AR3, Bowrey DJ. (PubMed)
Cancer is a class of diseases characterized by cell growth and multiplied disorderly and uncontrollably. In the advanced stage, cancerous cells from the originated site can travel a distance away to infect other healthy tissue via lymph or blood circulation.
Most cancers process a high survival rate if they are diagnosed early. According to the Mayo Clinic, over 56 percent of people diagnosed with early-stage lung cancer live for at least five years after diagnosis. However, the five-year survival rate for people diagnosed with late-stage of invasive lung cancer is 5 %.
According to the statistic on Canadian cancer provided by the government, in 2017, there were over 200,000 newly diagnosed cancer and 80,000 Canadians died from cancer. 1 in 2 Canadians will be diagnosed with cancer, and 1 in 4 will die from the disease, during their lifetime.
The exact cause of cancers is unknown. Researchers do not know why some people without gene mutation are susceptible to early onset of cancer while others do not
However, researchers do know that certain risk factors such as aging, tobacco, sun exposure, radiation exposure, chemicals, and other substances, some viruses and bacteria, certain hormones, family history of cancer, alcohol, poor diet, and physical inactivity are associated to gene change in the initiation of cancer development.
Most cancers share the common symptoms of tiredness, unexplained weight loss, loss of appetite, and fatigue. In the advanced stage, cancer patients may also experience additional common symptoms of dehydration, nausea and vomiting, constipation, and persistent pain.
Gastroesophageal adenocarcinoma is a rare type of cancer of the esophagus, the tube that connects your mouth and stomach.
The most common risk factors associated with the onset of esophagogastric adenocarcinoma are
* Having gastroesophageal reflux disease (GERD)
* Smoking.
* Having precancerous changes in the cells of the esophagus (Barrett's esophagus)
* Being obese.
* Excessive alcohol drinking
* Frequent bile reflux.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
In finding a potential phytochemical for the treatment of cancer, researchers investigated the effects of omega-3 fatty acids in patients with advanced esophagogastric adenocarcinoma.
The study included 20 participants with advanced esophagogastric adenocarcinoma enrolled in phase II single-arm clinical trial of palliative chemotherapy (epirubicin, oxaliplatin, and capecitabine; EOX) coupled with the weekly infusion of Omegaven®.
According to the results of radiological responses,
* Partial response (EOX plus omega-3 group 73% vs. EOX alone 39%, p=0.03).
*Stable disease (EOX plus omega-3 21% vs. EOX alone 39%, p=0.24), and
* Progressive disease (EOX plus omega-3 7% vs. EOX alone 18%, p=0.34).
Most importantly, grade 3 or 4 toxicity was less common (thromboembolism & gastrointestinal) and the concentrations of pro-inflammatory proteins such as IL-2 (p=0.009), TNF-α (p<0.0001), and VEGF (p=0.002) was reduced. in those who received EOX plus omega-3.
Based on the evidence, researchers said, "The treatment with supplementary omega-3 fatty acids reduced chemotherapy-related toxicity and resulted in better radiological responses".
Taken together, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered an adjunct therapy in the treatment of advanced esophagogastric adenocarcinoma, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The Effect of Supplementary Omegaven® on the Clinical Outcome of Patients With Advanced Esophagogastric Adenocarcinoma Receiving Palliative Epirubicin, Oxaliplatin, and Capecitabine Chemotherapy: A Phase II clinical trial by Eltweri AM1, Thomas AL2, Chung WY3, Morgan B3, Thompson J4, Dennison AR3, Bowrey DJ. (PubMed)
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