#Enzyme #Bromelain Inhibits the Proinflammatory Cytokine Against the Onset of Colitis, Scientists Say

By Kyle J. Norton

Colitis is a medical condition characterized by the inflammation of the large intestine, including the colon, caecum, and rectum.

Depending on the type of colitis, the most common prevalent factors found in patients with such as condition are.
* Familial history of inflammatory bowel disease (odds ratio (OR) 4.3)

* Breastfeeding (OR 2.1)

* Bacille Calmette-Guerin vaccination (OR 3.6 )

* History of eczema (OR 2.1 (1-4.5))

* Disease during pregnancy (OR 8.9 (1.5-52)), and

* Bedroom sharing (OR 7.1 (1.9-27.4))

* Crohn's disease both appendectomy and tonsillectomy have positive associations. Well-established

* Smoking status

* If you are over 50, you are at increased to develop colitis.

And * Depression and psychosocial stress, according to the basis of data from the Nurses' Health Study, increase the risk for CD, but not UC, among women. Psychological factors might have been found to induce CD development.

Furthermore, patients with medicals condition such as hypertension, diabetes, hyperlipidemia, and atrial fibrillation are associated with an increased risk to develop ischemic colitis(IC), according to the study by Beijing Hospital, Ministry of Health.

Believe it or not, regular drinking of tap water was a protective factor and ulcerative colitis appendicectomy was a protective factor.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a potential compound for the treatment of colitis, researchers examined the effects of bromelain on the inflammatory response that lead to the onset of colitis.

In epithelial TNFR in rats colitis induced by the intracolonic administration of 2, 4, 6-trinitrobenzene sulfonic acid, injection of purified fruit bromelain (PFB) significantly decreased the increased expression of TNFR1 and TNFR2.

Where TNF-α receptor (TNFR) is a proinflammatory cytokine activated by the immune response.

Furthermore, typical symptoms associated with colitis such as infiltration of inflammatory cells, cytokine profiles, epithelial cell apoptosis, and epithelial tight junction barrier dysfunction were significantly ameliorated by PFB.


According to the chemical analysis, fruit bromelain showed a superior inhibition of TNFR2 than that exhibited on TNFR1 compared to those of stem bromelain complex.

In other words, PFB expressed its anti-inflammatory activity by blocking the activation of high expression of epithelial TNFRs.

Based on the findings, researchers said, "PFB-induced TNFR inhibition ameliorated colitis symptoms. These results supply novel insights into potential IBD treatment by PFB".

In other to reveal more information on bromelain anti-colitis effects, researchers evaluated the long-term dietary supplementation with pineapple (supplied as juice) in decreasing colon inflammation and neoplasia in Il10(-/-) mice with chronic colitis as compared with bromelain derived from the stem.

Colitis triggered in Il10(-/-) mice by exposure to the non-steroidal anti-inflammatory drug piroxicam for 6 months showed decreased histologic colon inflammation scores and lower incidence of inflammation-associated colonic neoplasia (35% versus 66%; P < 0.02), with fewer neoplastic lesions/colon (P = 0.05) after receiving treatment of fresh juice.

According to the tested assays, fresh pineapple juice demonstrated proteolytic activity in removing cell surface molecules that can affect leukocyte response.

Dr. Hale LP, the lead scientist wrote in the final report, "Long-term dietary supplementation with fresh or unpasteurized frozen pineapple juice with proteolytically active bromelain enzymes is safe and decreases inflammation severity and the incidence and multiplicity of inflammation-associated colonic neoplasia in this commonly used murine model of inflammatory bowel disease".

Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of colitis associated with inflammatory bowel disease, pending to the confirmation of the larger sample size and multicenter human study.


Intake of bromelain in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis by Hale LP1, Chichlowski M, Trinh CT, Greer PK. (PubMed)
(2) Inhibition of Epithelial TNF-α Receptors by Purified Fruit Bromelain Ameliorates Intestinal Inflammation and Barrier Dysfunction in Colitis by Zhou Z1, Wang L1, Feng P1, Yin L2, Wang C3, Zhi S3, Dong J1, Wang J1, Lin Y2, Chen D1, Xiong Y4,5, Peng J. (PubMed)
(3) Colitis - The Risk Factors by Kyle J. Norton

#Antioxidant #Betaxanthins Protect the the Arteries Agianst the Risk of #Stenosis, Researchers Show

By Kyle J. Norton


Stenosis of the arteries is a narrowing large artery caused by the accumulation of plaques located on each side of the neck that carries blood to the head, face, and brain.

The most common causes of stenosis of the arteries are results from atherosclerosis.

Untreated stenosis of the arteries has been found to induce complications of transient ischemic attack or stroke, depending on a blot clot that briefly blockage or partly or completely blockage of a blood vessel to the brain.

Atherosclerosis is a medical condition caused by plaque accumulated on the wall of arteries, leading to the narrowing of the artery and reducing oxygen risk blood flow to the heart and brain.

Depending on the location of the blockage, if the reduced blood flow occurred in the brain, it will cause the death of the brain cells, leading to stroke.

However, if the reduced blood flow occurred in the heart, it will cause damage to the heart tissues, leading to heart disease.

The most common disease associated with atherosclerosis is coronary artery disease. Plaques are made up of cholesterol, calcium, and other chemical substances in the artery

Most people with atherosclerosis are asymptomatic at the early stage.

Some researchers suggested that atherosclerosis is a lipoprotein-driven disease. Therefore, people with high blood cholesterol are at an increased risk of atherosclerosis. Overuse of calcium supplements is also found to elevate the condition risk, particularly in the elderly.

Other risk factors that have bee found epidemiologically by studies are high blood pressure, triglycerides, smoking, insulin resistance, obesity or diabetes and inflammatory diseases, such as arthritis, lupus or infections.

Most cases of atherosclerosis can be reversed by making a change of lifestyle and moderate exercise. However, in severe cases surgery to remove plaque from the artery may be the only option.

Betaxanthins are Phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, Sicilian prickly pear, etc.

On finding a potent ingredient for the treatment of cardiovascular disease, researchers investigated the effects of betalains, consisting of betacyanins and betaxanthins on the stenosis of the arteries.

In vivo and in vitro studies, betalains and betalain-rich diets is not only safe but also inhibited oxidative stress-, inflammation-, and dyslipidemia-related diseases associated with narrowing arteries involved in atherosclerosis, or a build-up of plaque on the inside of the arteries.

Furthermore, betalains and betalain-rich diets are safe toxicological safety, incorporated with easy accessibility, low price, biodegradability, and potentially advantageous biological effects on health.


These results strongly suggested betalains may be used in food manufacturing and related industries to overcome current concerns over the health risks of artificial colors.

Dr. Rahimi P, the lead scientist wrote, "(Even with the efficacy), further studies using pure betalains are required to gain a deeper understanding of their precise biological functions".

Taken altogether, betaxanthins found abundantly in betalains and betalain-rich diets may be considered anti-atherosclerotic remedy, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Betalains, the nature-inspired pigments, in health and diseases by Rahimi P1, Abedimanesh S1, Mesbah-Namin SA1, Ostadrahimi A. (PubMed)

#Healthyfood #Garlic in Reducing the Risk of #BreastCancer, According to Studies

By Kyle J. Norton

Garlic is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating the common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.

Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there are also rare cases that breast cancer starts in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Fresh Garlic Extract beside inhibited colon and gastric cancer in 2 previous articles, it has also been found to arrest the growth and alter the morphology of MCF7 breast cancer cells.

Also in MCF7 human breast cancer cells, garlic constituent diallyl trisulfide has highly effective antitumor effects by the suppressing viability of cultured MCF-7 and MCF-12a cells, through the decreased percentage of cells in G(2)/M and induced apoptotic cell death.

According to the study by 201 South University Street, diallyl trisulfide, inhibited the expression of MDA-MB-231 and MCF-7 breast cancer cells, regardless of the state of estrogen in the tumors.

In a total of 285 women (aged 25-65 years old) newly diagnosed with histopathologically confirmed breast cancer, dietary Allium Vegetables have a negative association between the consumption of raw onion and the risk of breast cancer.

Dr. Roy N., the lead author at the Kerala Agricultural University, said, "Docking studies and ADMET evaluation revealed twelve compounds (isolated from garlic) to be active against the targets(breast cancer cell lines). All the compounds displayed highly negative dock scores which indicated good interactions".

Therefore, the effectiveness of garlic in reducing the risk and treatment of breast cancer is probably due to the existence of many phytochemicals found in the herb. Women who increased their intake of garlic every day may see the risk of breast cancer reduced substantially.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Fresh Garlic Extract Induces Growth Arrest and Morphological Differentiation of MCF7 Breast Cancer Cells by Modem S1, Dicarlo SE, Reddy TR.(PubMed)
(2) Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells by Malki A1, El-Saadani M, Sultan AS.(PubMed)
(3) Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells by Kiesel VA1, Stan SD2.(PubMed)

#Healthyfood #Gingers Inhibit the Symptoms and Disabilities of #Osteoarthritis, According to Scientists

By Kyle J. Norton

Ginger may be considered a natural whole food to treat osteoarthritis with no side effects, some scientists suggested.
Osteoarthritis is a chronic inflammatory disease, as a result of the protective cartilage on the ends of your bones being worn and torn down over time. The disease affects millions of people worldwide.

In contrast to the general belief, osteoarthritis only damages the joints of the hands and knees, but also causes inflammation of the joints in your hips and spine.

The condition is a slow development disease, often starting in the 40s and 50s, and affects almost all people to some degree by age 80.

The common risk factors of osteoarthritis are aging, gender, improper healing of injured joints at a young age, obesity, and bone deformity. However, people who have a job with tasks that place repetitive stress on a particular joint are associated with the onset of osteoarthritis in most industrial countries.

Dr. Berran Yucesoy, the lead author in the concerns of the repetitive occupation associated with the risk of osteoarthritis launched an investigation to examine the occupational that contribute to this debilitating condition.

The results of searching the medical data on PubMed using the search terms osteoarthritis, occupation, work, and genetics wrote, " One of the most common occupational risk factors for knee OA is heavy physical workload" and "Other risk factors include frequent exposure to several biomechanical stressors such bending of the knee, kneeling or squatting, standing for long hours (≥ 2 hours per day), walking ≥ 3 km/day, regular stair climbing, heavy lifting (≥ 10 kg), jumping, and vibration".

Believe it or not, the researcher continued, " a more than the five-fold greater risk of knee OA among workers ≥ 55 years who were exposed to a combination of heavy lifting (> 25 kg) and kneeling/squatting or climbing stairs".

If your occupation is in the group mentioned in the study, you are likely to develop osteoarthritis at a younger age. Please make sure you are taking all preventive measures to reduce the risk of the onset of the disease later in life


Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The pungent and kitchen spice has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find evidence that ginger powder consumption can relieve pain and inflammation due to specific anti-inflammatory phytochemical constituents, researchers at the joint investigation led by the Shahid Sadoughi University of Medical Sciences launched a study to examine the effect of ginger supplementation on proinflammatory factors.

The randomized double-blind placebo-controlled 3-month clinical trial investigating knee osteoarthritis includes 120 participants assigned to one of two groups: the ginger group (GG) or the placebo group (PG).

Participants in the GG intervention received capsules containing 500 mg of ginger powder, while PG participants received capsules filled with 500 mg of starch.

At 3 months, the expression of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) cytokines were found to decrease substantially in the GG compared to the PG.

Dr. Mozaffari-Khosravi H, the lead scientist wrote in the final report " Ginger supplementation may have promising benefits for knee osteoarthritis".

Furthermore, the assessment of the clinical efficacy and safety of oral ginger for the symptomatic treatment of osteoarthritis (OA) by carrying out a systematic literature search followed by meta-analyses on selected studies in randomized controlled trials (RCTs) comparing oral ginger treatment with placebo in OA patients aged >18 years also suggested that

* Ginger intake shows a statistically significant pain reduction with a low degree of inconsistency among trials.

* The ginger treatment group also demonstrates a statistically significant reduction in disability.

* Patients given ginger are more than twice as likely to discontinue treatment compared to placebo. And,

* Ginger was modestly efficacious and reasonably safe for the treatment of OA.

Taken altogether, through the inhibition of pro-inflammatory factors, ginger, and a ginger supplement may be considered for the prevention and adjunct therapies combined with primary medicine for the treatment of osteoarthritis.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial by Mozaffari-Khosravi H1,2, Naderi Z1, Dehghan A3, Nadjarzadeh A1, Fallah Huseini H. (PubMed)
(2) Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials by Bartels EM1, Folmer VN2, Bliddal H2, Altman RD3, Juhl C4, Tarp S2, Zhang W5, Christensen R. (PubMed)
(3) Occupational and genetic risk factors for osteoarthritis: A review by Berran Yucesoy,∗ Luenda E. Charles,b,1 Brent Baker,a and Cecil M. Burchfiel. (PMC)

#Phytochemical #Sinigrin Found in #Cruciferousvegetables Speeds Up Wound Healing in Vitros, Researchers Find

By Kyle J. Norton

Sinigrin may be used as a natural and bioactive compound to speed up wound healing, according to studies.
Wound healing is a natural process of an immune system response to protect our body against harmful pathogenic invasion.

After receiving the message from the neurons in the brain, the immune first line of defense including the macrophages stimulates the blood palettes to the site of infection to cover the injury and production of pro-inflammatory cytokines to kill off the stimuli and pathogens which try to enter the body through the wound.

Some anti-inflammatory cytokines under normal conditions also switch to pro-inflammatory cytokines depending on the severity of the injury.

In some cases, overproduction of pro-inflammatory cytokines can cause damage or death of the nearby cells, leading to the formation of irreversible scars, such as hepatitis infection.

Even worse, if the immune system can not kill off all pathogens in the acute phase of infection, it will compromise to the new change, leading to chronic low-grade inflammation.


Bacterial pathogens often cause infection in specific areas of the body by overgrowth of the number of bacteria in the site, including the gut.

According to epidemiological studies, some bacteria are opportunistic pathogens, and people with a weakened immune system are particularly prone to their invasion.

Dr. Dennis W. Metzger, the lead scientist wrote, " While it has been commonly thought that viral-induced epithelial cell damage allows bacterial invasiveness, recent studies by several groups have now implicated dysfunctional innate immune defenses following influenza as the primary culprit for enhanced susceptibility to secondary bacterial infections".

The results strongly indicated the increased risk of bacterial infection in people with a weakened immune system.

Researchers on finding a natural compound for speeding up wound healing explored the wound healing effect of sinigrin on HaCaT cells.


In the phytosome with sinigrin with an average particle size of 153 ± 39 nm, the zeta potential of 10.09 ± 0.98 mV and complex efficiency of 69.5 ± 5%.

The formulated sinigrin-phytosome complex significantly exhibited a greater wound-healing effect compared to the use of sinigrin alone.

Compared to only 71% of wounds closer to sinigrin after 42 hours, the phytosome complex completely healed the wound.

At a lower concentration of 0.07 mg/mL, the sinigrin–phytosome complex displayed 79%, whilst sinigrin showed only 50% of wound closure.


At the higher concentration of 0.14 mg/mL the sinigrin–phytosome complex completely cured the wound (100%), compared to only 71% wound healing of sinigrin.

Furthermore, The sinigrin-phytosome complex displayed minimal toxicity towards HaCaT cells.


Injection of the complex also exerted a strong effect on A-375, a human melanoma cell line.


Dr. Mazumder A, after taking into account co and confounders wrote at the end of the experiment, " sinigrin-phytosome complex augmented the therapeutic potential of sinigrin towards the wound healing activity".

Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for speedup wound healing, pending the confirmation of a large sample size and multicenter human study.


However, intake of bioactive in the form of supplements should be taken with extreme care, as liver toxicity may be induced if overdosed.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (Molecules)
(2) In vitro wound healing and cytotoxic effects of sinigrin-phytosome complex by Mazumder A1, Dwivedi A1, du Preez JL1, du Plessis J2.(Pubmed)
(3) Immune Dysfunction and Bacterial Co-Infections following Influenza by Dennis W. Metzger and Keer Sun. (PMC)

#Herbal #Anise Exhibits #Antioxidant Activities Against the Onset of #GastricUlcers, Researchers Say

Anise may have a potential and substantial effect in reduced risk and progression and treatment of gastric ulcers, some scientists suggested.
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic,...


In the evaluate the claim of Unani and Arabian traditional medicine practitioners on the gastroprotective potential effect by using 80% ethanol, 0.2 mol/L NaOH, 25% NaCl, and indomethacin-induced gastric ulceration and secretion in a rat model, researchers found that application of doses of 250 and 500 mg/kg body weight of Anise exert a significant protective activity against basal gastric acid secretion, acidity and completely inhibited the ruminal ulceration caused by necrotizing agents, by initiating production of depleted levels of gastric mucosal NP-SH and gastric wall mucus concentration.

Further analysis suggested that the anti-gastric ulcers of Anise suspension were attributed to the herbal medicine antioxidants in enhanced production of hormone prostaglandins in inhibited levels of gastric secretion.

The hormone has been studied intensively for the protection and treatment of gastric ulcers by some scientists due to its effect in promoting rapid restitution of the superficial epithelium of the gastric mucosa and preservation of the deeper layers through the ability of the hormones in inhibited gastric secretion, stimulated bicarbonate secretion, and increased gastric blood volume.

According to Dr. Wilson DE, "Orally administered prostaglandin analogs have been helpful in some patients who failed to heal with standard ulcer treatment and in smokers, who usually do not heal as well as nonsmokers".


Some researchers suggested that prostaglandin analogs may be the ideal solution for patients who are at high risk for gastric lesions due to chronic consumers of nonsteroidal anti-inflammatory drugs or alcohol.

Moreover, in the investigation of the effect of essential oil isolated from Croton zehntneri (EOCZ), a plant native to northeastern Brazil, and anethole at doses of 30–300 mg/kg, researchers found that the composition demonstrated a strongly and linearly gastroprotective effect against ethanol- and indomethacin-induced gastric damage without changing to cold-restraint stress-induced ulcers in rats.

According to the measurement by Alcian blue binding assay, EOCZ and anethole (both at 30 and 300 mg/kg) similarly and significantly increased the mucus production by the gastric mucosa.

Additionally, the composition also consisted a significant effect on the volume of gastric juice, pH, or total acidity through its ability of EOCZ and anethole in enhanced production of gastric wall mucus.


The above of differentiation was supported by the study to test the major bioactive compound anethole effect in the ethanol-induced ulcer model in mice conducted by the joint investigation led by Coordenação do Curso de Farmácia,


According to the results, after taking into account other co-founders, the application of anethole (300 mg/kg) increased the level of gastric mucus, while derivatives (300 mg/kg) showed gastroprotective activity without affecting mucus secretion, through anethole antioxidant and anti-inflammation activities.

By examining the antioxidant aspects in the experiment mice, researchers surprisingly found that anethole exhibited a protective gastric effect through reduced oxidative stress caused by induced suspension in the activated gastric mucosal nitric oxide (NO) in maintaining gastric mucosal integrity and improving the production of the natural antioxidants in the host body, including glutathione (GSH), lipid peroxide (MDA, measured as malondialdehyde) glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase.

Importantly, anethole also reduced oxidative stress in initiated levels of pro-inflammatory substances of plasma tumor necrosis factor-α with function involved in systemic inflammation in the acute phase reaction and interleukin-1β and IL-6 in regulated immune response in protecting the host against bacterial and viral in the induction of infection.

Taken together, herbal Anise and its major chemical constituent anethole may be considered a secondary therapy accompanied by conventional medicine for the treatment of gastric ulcers. However, the intake of Anise supplements should be taken with extreme care in the prevention of acute liver toxicity.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.


Sources
(1) Aqueous suspension of anise “Pimpinella anisum” protects rats against chemically induced gastric ulcers by Ibrahim A Al Mofleh, Abdulqader A Alhaider, Jaber S Mossa, Mohammed O Al-Soohaibani, and Syed Rafatullah(PubMed Central Canada)
(2) Prostaglandins in peptic ulcer disease. Their postulated role in the pathogenesis and treatment by Wilson DE(PubMed)
(3) Anti-Ulcer Activity of Essential Oil Constituents Francisco de Assis Oliveira 1 , Luciana Nalone Andrade 2 , Élida Batista Vieira de Sousa 3 and Damião Pergentino de Sousa(Open Access)
(3) Essential oil of Croton zehntneri and its major constituent anethole display gastroprotective effect by increasing the surface mucous layer by Andrelina N. Coelho-de-Souza, Saad Lahlou, João E.F. Barreto, Maria E.M. Yum, Ariclécio C. Oliveira, Hermógenes D. Oliveira, Nathalia R. Celedônio, Roney G.F. Feitosa, Gloria P. Duarte, Cláudia F. Santos, Aline A.C. de Albuquerque, José H. Leal-Card(Fundamental and Clinical Pharmacology)

Antioxidant #Indicaxanthin Inhibits the Onco-#Suppressor Gene Associated with the Risk of #ColonCancer, Researchers Find

By Kyle J. Norton

The colon formed part of the digestive system, is the 2nd part of intestines found in the large bowel consisting of the colon and rectum. The colon plays a critical role to absorb water from the small bowel contents and breaking down certain materials in the feces into substances in which some of which are reabsorbed and reused by the body.

Cancer is a class of chronic diseases caused by cell DNA alternation in the tissue of a specific organ.
The invasive tumor tends to spread to other nearby healthy tissue compared to a noninvasive and benign tumor.

Colon cancer is a chronic condition characterized by irregular cell growth that starts in the cells in the inner lining of the tissues of the colon tissues, after penetrating into deeper layers to form a tumor, through the unlimited cell cycle division.

Colon cancer is relatively very common, slowly growing and progressing in a predictable way.

However, at the advanced stage, colon cancerous cells can travel a distance away to invade other healthy tissue, leading to secondary metastasis.

Together with rectal cancer, colorectal cancer is the third most commonly diagnosed cancer in Western countries, including the US and Canada.

According to the statistics, the lifetime risk of developing colon cancer is about one in 23. Colon cancer accounts for 71% of all cases of colorectal cancer. The overall 5 years survival rate of localized colon cancer is 90%.

The 5-year survival rate of colon cancer is 90%. Only 39% of patients are diagnosed in the localized stage.

Dr. Bandaru S. Reddy, in examining the types and amount of dietary fat and colon cancer risk wrote, "The role of types of dietary fat, especially saturated fats of animal origin, n−6- and n−3-rich polyunsaturated fatty acids (PUFAs) in the etiology of colorectal cancer has become increasingly apparent".

And, "Epidemiological studies indicate a positive association between the dietary intake of saturated fat and/or animal fat and colon cancer risk and an inverse relationship between the intake of fish and fish oil rich in n−3 PUFAs and colon cancer development".

In other words, if you follow the Western diet, you are at an increased risk of colon cancer.

Indicaxanthin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.

In finding a potent compound for the treatment of cancer, researchers examined the potential influence of consistent dietary concentrations of indicaxanthin on LOVO1, CACO2, HT29, HCT116, and DLD1 cells.

According to the tested analysis, Indicaxanthin exerted a significant anti-proliferative activity in all cell lines but HT29 by inhibiting some methylation-silenced on-co-suppressor genes.

In other words, Indicaxanthin normalized the gene expression associated with cancer cell suppression without affecting the function of basally hypermethylated such as SFRP1 and HPP1.


Interestingly, indicaxanthin increased the DNA Methyltransferases (DNMT) gene expression but decrease the activity involved in the promotion of various types of cancer, including colon cancer.


Most importantly, Indicaxanthin also increased the expression of genes involved in DNA demethylation associated with the activity of unwanted DNA methyltransferase-induced tumor progression.

Based on the findings, researchers said, "contribute to new knowledge in the field of phytochemicals and specifically suggest dietary indicaxanthin as a potential epigenetic agent to protect colon cells against tumoral alterations".

Taken altogether, indicaxanthin may be considered a remedy for the prevention and treatment of colon cancer, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phytochemical Indicaxanthin Inhibits Colon Cancer Cell Growth and Affects the DNA Methylation Status by Influencing Epigenetically Modifying Enzyme Expression and Activity by Naselli F1, Belshaw NJ, Gentile C, Tutone M, Tesoriere L, Livrea MA, Caradonna F. (PubMed)
(2) Types and amount of dietary fat and colon cancer risk: Prevention by omega-3 fatty acid-rich diets by Bandaru S. Reddy. (PMC)