By Kyle J. Norton
Cytotoxicity is a process or action that destroys living cells, through activating the production of pro-inflammatory cytokines and proteins associated with cell apoptosis and programmed cell death.
Free radical cytotoxicity is the ability of ROS in exerting oxidative stress in the cancer cells, leading to apoptosis.
Cancer is a class of diseases characterized by irregular cell growth due to DNA alternation.
Most cancers do not cause any symptoms at an early stage. However, at the later stage, a larger size of tumor can press on the nearby blood vessels and nerve cells, causing localized bleeding and severe pain.
The most common symptoms of cancer are unintended weight loss, loss of appetite, fatigue or tiredness, and gastrointestinal discomforts and symptoms depending on the location of the cancer.
If you experience some of the above symptoms, please check with your doctor to rule out the p[ossibility of the disease.
The causes of cancer are unknown. Researchers can not explain why people with the same health conditions, and family history in the same family, are susceptible to cancer, while others do not.
In normal cells, overproduction of free radicals or oxidative stress can affect the cell lipid, and protein, leading to cell damage or alteration of cell DNA.
Most cases of natural remedies initiating the cytotoxic effects against cancer without causing nearby healthy cell death probably are associated with the stimulation of the production of antioxidants produced by the host and the presence of antioxidants in the remedy.
Bilberry is a species of low-growing shrub in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
Researchers on finding a natural compound with cytotoxic potency examined the bilberry chemical compound in facilitating the onset of cytotoxicity against cancer and neutralizing the neuro cytotoxicity against the formation of plague on K562 Human Erythroleukemic cancer cells and Alzheimer's diseases (AD), respectively.
GroES self-assembled into amyloid fibrils similar to those observed in various neurodegenerative diseases was found to induce cell toxicity.
Before the application of bilberry anthocyanins, injection of soluble intermediate aggregates of GroES exhibited neuronal cell death, rather than forming mature fibrils.
Pretreatment with anthocyanins isolated from bilberry, not only inhibited both fibril formation but also neutralized the toxicity of intermediates.
The findings strongly suggested anthocyanins process an inhibitory effect on the amyloid fibril formation of various conformational disease-causing proteins.
Oppositely, from a cancer perspective, anthocyanins stimulated the tumor suppressor genes to induce apoptosis in cancer cells.
Dr. Seth P. Thibado and colleagues in the study to enhance the chemical compound bioavailability, observed the cytotoxicity of anthocyanins in an encapsulated in 5.5 nm diameter liposomal micelles, called NutraNanoSpheres (NNS), at a concentration of 2.5 mg/50 µl [25% (w/w) anthocyanins].
Bilberry NNS induced the apoptotic/cytotoxic effects on K562 Human Erythroleukemic cancer cells.
The concentrations of bilberry demonstrated the greatest levels of percentage inhibition of 60–70% at 0.018–1.14 mg/ml (n=6) and 60% inhibition at 4 mg/ml, compared to the control.
And, the lowest percentage of inhibition (30%) occurred at 2 mg/ml. The lethal dose 50 was determined to be 0.01–0.04 mg/ml of Bilberry per 105 K562 cells at 72 h of cell culture exposure.
At 48 h incubation, the highest percentage of inhibition was only 27%,.
The findings clearly suggested that NutraNanoSpheres (NNS) demonstrates direct cytotoxic effects, at a concentration that is 8–40 times lower than the levels required for bilberry if not encapsulated.
Taken altogether, bilberry-processed abundantly bioactive ingredient anthocyanins may be considered a functional remedy in the modulation of the cytotoxic activity against cancer, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bilberry anthocyanins neutralize the cytotoxicity of co-chaperonin GroES fibrillation intermediates by Iwasa H1, Kameda H, Fukui N, Yoshida S, Hongo K, Mizobata T, Kobayashi S, Kawata Y. (PubMed)
(2) Anticancer effects of Bilberry anthocyanins compared with NutraNanoSphere encapsulated Bilberry anthocyanins by Seth P. Thibado,1 Jerry T. Thornthwaite,2 Thomas K. Ballard,2 and Brandon T. Goodman. (PMC)
Sunday 28 May 2023
#Phytochemicals #Lycopene Inhibits the Overpression Free Radicals that Cause Cancers, Researchers Find
By Kyle J. Norton
NADPH oxidases, a multisubunit enzyme comprising membrane and cytosolic components plays a critical role to protect our body against pathogenic microorganism by maintaining the immune function, cell growth, and apoptosis.
NOX family of NADPH oxidases deficiency can cause immunosuppression, leading to the overexpression of intracellular ROS that results in various lethal diseases.
Epidemiologically, diseases associated with the NOX family of NADPH oxidases deficiency-induced immunosuppression are frequent and recurrent pneumonia, bronchitis, sinus infections, ear infections, meningitis or skin infections, inflammation, and infection of internal organs, blood disorders, such as low platelet counts or anemia, digestive problems, such as cramping, loss of appetite, nausea and diarrhea and delayed growth and development, particularly in cancer developing.
The NOX family of NADPH oxidases overexpression caused by a defect of its different subunits produced high levels of ROS in the gastrointestinal tract that causes chronic inflammatory stress; cytokine induction, leading to the formation of digestive cancer such as colorectal cancer.
A recent joint study led by the National Cancer Institute suggested that lycopene may be used for the treatment of cancer that targets the expression of NADPH oxidase 4-5 (NOX4-5).
Cancer is a class of diseases caused by cell growth irregularly and uncontrollably due to the alternation of cell DNA. Over time, cancer cells induced tumor formation to become progressively worse, leading to secondary metastasis.
Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas.
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
In patients with chronic pancreatitis, overexpression of free radicals has been found to orchestrate pancreatic cancer.
Furthermore, NOX4 overexpression increased the pre-malignant fibrotic states that lead to carcinomas of the lung and liver.
High expression of NOX5 is also found in patients with malignant melanomas, prostate cancer, and Barrett's esophagus-associated adenocarcinomas,
NOX4 and 5 are members of the NOX family of NADPH oxidases.
Furthermore, lycopene administration in vitro and Vivo significantly inhibited NOX4 protein expression at 2.5 μM, compared to other concentrations.
The efficacy of lycopene ameliorated the expression of NOX4 protein was attributed to the significant inhibition of the NOX4 mRNA expression associated with the function of NOX in the production of reactive oxygen species.
Dr. Roy K, the lead scientist in the investigation of the risk of cancer in the NOX family of NADPH oxidases wrote, "Over-expression of functional NOX proteins in many tissues helps to explain tissue injury and DNA damage from ROS that accompany pre-malignant conditions, as well as elucidating the potential mechanisms of NOX-related damage that contribute to both the initiation and the progression of a wide range of solid and hematopoietic malignancies".
In SK-Hep-1 cells, intracellular ROS levels were also decreased by the injection of lycopene.
Moreover, the levels of NOX4 protein expression, NOX activity, and the intracellular ROS associated with transforming growth factor β (TGF-β)-induced cancer cell metastasis also were eradicated by the activity of lycopene upon injection.
Other mechanisms such as proteins involved in anti-apoptosis and enhanced cancer cell migration, invasion, and adhesion were also inhibited by the expression of lycopene.
Taken altogether, lycopene may be considered a natural remedy for the prevention of cancer cell metastasis associated with the overexpression of NADPH oxidase, pending to the confirmation of larger sample size and multicenter studies.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene Inhibits Metastasis of Human Liver Adenocarcinoma SK-Hep-1 Cells by Downregulation of NADPH Oxidase 4 Protein Expression by Jhou BY1, Song TY2, Lee I3, Hu ML1,4, Yang NC. (PubMed)
(2) NADPH oxidases and cancer by Roy K1, Wu Y2, Meitzler JL2, Juhasz A2, Liu H1, Jiang G2, Lu J2, Antony S2, Doroshow JH. (PubMed)
NADPH oxidases, a multisubunit enzyme comprising membrane and cytosolic components plays a critical role to protect our body against pathogenic microorganism by maintaining the immune function, cell growth, and apoptosis.
NOX family of NADPH oxidases deficiency can cause immunosuppression, leading to the overexpression of intracellular ROS that results in various lethal diseases.
Epidemiologically, diseases associated with the NOX family of NADPH oxidases deficiency-induced immunosuppression are frequent and recurrent pneumonia, bronchitis, sinus infections, ear infections, meningitis or skin infections, inflammation, and infection of internal organs, blood disorders, such as low platelet counts or anemia, digestive problems, such as cramping, loss of appetite, nausea and diarrhea and delayed growth and development, particularly in cancer developing.
The NOX family of NADPH oxidases overexpression caused by a defect of its different subunits produced high levels of ROS in the gastrointestinal tract that causes chronic inflammatory stress; cytokine induction, leading to the formation of digestive cancer such as colorectal cancer.
A recent joint study led by the National Cancer Institute suggested that lycopene may be used for the treatment of cancer that targets the expression of NADPH oxidase 4-5 (NOX4-5).
Cancer is a class of diseases caused by cell growth irregularly and uncontrollably due to the alternation of cell DNA. Over time, cancer cells induced tumor formation to become progressively worse, leading to secondary metastasis.
Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas.
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
In patients with chronic pancreatitis, overexpression of free radicals has been found to orchestrate pancreatic cancer.
Furthermore, NOX4 overexpression increased the pre-malignant fibrotic states that lead to carcinomas of the lung and liver.
High expression of NOX5 is also found in patients with malignant melanomas, prostate cancer, and Barrett's esophagus-associated adenocarcinomas,
NOX4 and 5 are members of the NOX family of NADPH oxidases.
Furthermore, lycopene administration in vitro and Vivo significantly inhibited NOX4 protein expression at 2.5 μM, compared to other concentrations.
The efficacy of lycopene ameliorated the expression of NOX4 protein was attributed to the significant inhibition of the NOX4 mRNA expression associated with the function of NOX in the production of reactive oxygen species.
Dr. Roy K, the lead scientist in the investigation of the risk of cancer in the NOX family of NADPH oxidases wrote, "Over-expression of functional NOX proteins in many tissues helps to explain tissue injury and DNA damage from ROS that accompany pre-malignant conditions, as well as elucidating the potential mechanisms of NOX-related damage that contribute to both the initiation and the progression of a wide range of solid and hematopoietic malignancies".
In SK-Hep-1 cells, intracellular ROS levels were also decreased by the injection of lycopene.
Moreover, the levels of NOX4 protein expression, NOX activity, and the intracellular ROS associated with transforming growth factor β (TGF-β)-induced cancer cell metastasis also were eradicated by the activity of lycopene upon injection.
Other mechanisms such as proteins involved in anti-apoptosis and enhanced cancer cell migration, invasion, and adhesion were also inhibited by the expression of lycopene.
Taken altogether, lycopene may be considered a natural remedy for the prevention of cancer cell metastasis associated with the overexpression of NADPH oxidase, pending to the confirmation of larger sample size and multicenter studies.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene Inhibits Metastasis of Human Liver Adenocarcinoma SK-Hep-1 Cells by Downregulation of NADPH Oxidase 4 Protein Expression by Jhou BY1, Song TY2, Lee I3, Hu ML1,4, Yang NC. (PubMed)
(2) NADPH oxidases and cancer by Roy K1, Wu Y2, Meitzler JL2, Juhasz A2, Liu H1, Jiang G2, Lu J2, Antony S2, Doroshow JH. (PubMed)
The Effects of #Herbal #Ashwagandha Cytostatic Activities on #MultipleMyeloma, Scientists Say
By Kyle J. Norton
Multiple myeloma (Myeloma) is a type of cancer that originated from plasma cells in the bone marrow.
The disease is a condition of DNA alternation of white blood cells normally responsible for the production of antibodies to protect our body against infection with some characteristics.
According to the statistics provided by the American Cancer Society, multiple myeloma is a relatively uncommon cancer. In the United States, the lifetime risk of getting multiple myeloma is 1 in 132 (0.76%).
Every year, approximately, 32,110 new cases are diagnosed, including 18,130 in men and 13,980 in women. The disease also causes the death of 12,960 Americans including 6,990 in men and 5,970 in women.
The Grades of multiple myeloma are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.
The exact causes of MS are unknown. Epidemiologically, the increase of age (If you are between 50 and 70 years old you are at higher risk to develop Multiple Myeloma), gender (men are more likely to develop multiple myeloma than women), race (Cancer tends to affects blacks more often than whites), previous multiple myeloma, exposed to certain chemicals, family history, and radiation
Most common symptoms of MS are* Bone pain
Abnormal growth of plasma cells can cause a collapse of the bone.
* Infection
Overcrowding of abnormal plasma cells reduces the functions of white blood cells produced by the bone marrow, leading to a weakened immune system. The most common infections found to be pneumonia and pyelonephritis.
* Anemia
As a result, malignant plasma cells have to interfere with the normal production of red blood cells.
* Bleeding
Due to the lower production of the platelet.
* Renal failure
Abnormal plasma cells can also affect the function of the kidney in getting rid of waste, causing urea and creatinine to accumulate in the bloodstream.
* Neurological symptoms
Due to hypercalcemia, as a result of the breakdown of the bone caused by the release of calcium into the bloodstream.
However, most people with some of the above symptoms never developed MS.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of tumor of the bone marrow, researchers examined the growth inhibitory effects of withanolide D (WND), a steroidal lactone isolated from Withania somnifera on drug-resistant subpopulation known as cancer stem cells (CSCs).
According to tested assays, WND exhibited similar cytostatic effects by inhibiting cancer cell growth and division. on drug-resistant and drug-sensitive cell lines in the nM range.
In cancer cell lines MM-CSCs and RPMI 8226, the administration of WND also induced cancer cell death and apoptosis.
However, WND did not increase the accumulation of the fluorescent P-gp substrate rhodamine 123 in MM-CSCs associated with cancer cells' drug resistance. More precisely, the result suggested that WND at the tested doses may not inhibit P-gp accumulation involved in the development of resistance of cancer cells to chemotherapeutic drugs.
Based on the findings, researchers said, " the WND-induced cytostatic effect may be independent of P-gp efflux".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of myeloma, pending the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Withanolide D Exhibits Similar Cytostatic Effect in Drug-Resistant and Drug-Sensitive Multiple Myeloma Cells by Issa ME1, Wijeratne EMK2, Gunatilaka AAL2, Cuendet M. (PubMed)
Multiple myeloma (Myeloma) is a type of cancer that originated from plasma cells in the bone marrow.
The disease is a condition of DNA alternation of white blood cells normally responsible for the production of antibodies to protect our body against infection with some characteristics.
According to the statistics provided by the American Cancer Society, multiple myeloma is a relatively uncommon cancer. In the United States, the lifetime risk of getting multiple myeloma is 1 in 132 (0.76%).
Every year, approximately, 32,110 new cases are diagnosed, including 18,130 in men and 13,980 in women. The disease also causes the death of 12,960 Americans including 6,990 in men and 5,970 in women.
The Grades of multiple myeloma are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.
The exact causes of MS are unknown. Epidemiologically, the increase of age (If you are between 50 and 70 years old you are at higher risk to develop Multiple Myeloma), gender (men are more likely to develop multiple myeloma than women), race (Cancer tends to affects blacks more often than whites), previous multiple myeloma, exposed to certain chemicals, family history, and radiation
Most common symptoms of MS are* Bone pain
Abnormal growth of plasma cells can cause a collapse of the bone.
* Infection
Overcrowding of abnormal plasma cells reduces the functions of white blood cells produced by the bone marrow, leading to a weakened immune system. The most common infections found to be pneumonia and pyelonephritis.
* Anemia
As a result, malignant plasma cells have to interfere with the normal production of red blood cells.
* Bleeding
Due to the lower production of the platelet.
* Renal failure
Abnormal plasma cells can also affect the function of the kidney in getting rid of waste, causing urea and creatinine to accumulate in the bloodstream.
* Neurological symptoms
Due to hypercalcemia, as a result of the breakdown of the bone caused by the release of calcium into the bloodstream.
However, most people with some of the above symptoms never developed MS.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of tumor of the bone marrow, researchers examined the growth inhibitory effects of withanolide D (WND), a steroidal lactone isolated from Withania somnifera on drug-resistant subpopulation known as cancer stem cells (CSCs).
According to tested assays, WND exhibited similar cytostatic effects by inhibiting cancer cell growth and division. on drug-resistant and drug-sensitive cell lines in the nM range.
In cancer cell lines MM-CSCs and RPMI 8226, the administration of WND also induced cancer cell death and apoptosis.
However, WND did not increase the accumulation of the fluorescent P-gp substrate rhodamine 123 in MM-CSCs associated with cancer cells' drug resistance. More precisely, the result suggested that WND at the tested doses may not inhibit P-gp accumulation involved in the development of resistance of cancer cells to chemotherapeutic drugs.
Based on the findings, researchers said, " the WND-induced cytostatic effect may be independent of P-gp efflux".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of myeloma, pending the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Withanolide D Exhibits Similar Cytostatic Effect in Drug-Resistant and Drug-Sensitive Multiple Myeloma Cells by Issa ME1, Wijeratne EMK2, Gunatilaka AAL2, Cuendet M. (PubMed)
#Antioxidant #Carotenoids Inhibit the OxidativeStress that Causes #CysticFibrosis (#CF)
By Kyle J. Norton
Cystic fibrosis (CF) is the most common fatal genetic disease affecting mostly the lung in Canadian children and young adults, leading to difficulty breathing and coughing up mucus and frequent lung infections.
However, the condition has also been found in the pancreas, liver, kidneys, and intestine.
According to the Cystic Fibrosis Foundation Patient Registry, more than 30,000 people are living with cystic fibrosis in the US.
Believe it or not, most cases of CF are diagnosed by age 2.
The most common symptoms are depending on the location of cystic fibrosis including
sinus infections, poor growth, fatty stool, and clubbing of the fingers and toes.
In male adults, the condition also induces infertility as a result of the blockage or absence of the sperm canal.
Conventionally, as of today, there is no cure for CF. Most cases of CF caused by lung infection are treated intravenously, inhaled, or by mouth.
In severe cases, a lung transplant may be the only option.
Although most cases of CF are associated with a genetic preposition, environment, lifestyle, and age are also 2 main factors that increase the risk of CF.
Cystic Fibrosis Canada in the investigation of the risk of CF in older adults wrote, "Today, the estimated median age of survival of CF patients in Canada is over 50 years, and the majority of patients are over 18 years of age. CF patients enjoy an improved quality of life, pursuing careers, and starting their own families".
Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
In finding a potential compound for the treatment of lung disease researchers examined the effects of carotenoids, the potent antioxidants on singlet oxygen and other toxic oxygen species in patients with cystic fibrosis (CF).
The study included a total of 17 patients with cystic fibrosis (CF) and 10 normal children,
According to the assessment of plasma levels of four carotenoids, beta-carotene, alpha-carotene, lutein, and lycopene, levels of carotenoids in children with CF were significantly lower compared to regular control participants.
There was no significant difference in total cholesterol and total carotene between groups. Furthermore, there was no correlation between fat absorption or measures of adiposity in children with CF compared to control.
However, levels of selected carotenoids were correlated negatively with serum IgG levels associated with the measurement of inflammation.
More importantly, researchers also found that the differences in plasma carotenoid levels between children with CF and normal children were involved in the rapid turnover of carotenoids, by quenching of toxic oxygen species in inflammatory states of CF.
The results strongly suggested that improving the concentration of carotenoids that reduces the implication of the toxic ROS expression may have an impact on the prevention and treatment of CF.
Intake of lycopene in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
Norton's
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Carotenoid levels in normal children and in children with cystic fibrosis by Homnick DN1, Cox JH, DeLoof MJ, Ringer TV. (PubMed)
(2) Living Longer WITH CYSTIC FIBROSIS by The Cystic Fibrosis Canada
Cystic fibrosis (CF) is the most common fatal genetic disease affecting mostly the lung in Canadian children and young adults, leading to difficulty breathing and coughing up mucus and frequent lung infections.
However, the condition has also been found in the pancreas, liver, kidneys, and intestine.
According to the Cystic Fibrosis Foundation Patient Registry, more than 30,000 people are living with cystic fibrosis in the US.
Believe it or not, most cases of CF are diagnosed by age 2.
The most common symptoms are depending on the location of cystic fibrosis including
sinus infections, poor growth, fatty stool, and clubbing of the fingers and toes.
In male adults, the condition also induces infertility as a result of the blockage or absence of the sperm canal.
Conventionally, as of today, there is no cure for CF. Most cases of CF caused by lung infection are treated intravenously, inhaled, or by mouth.
In severe cases, a lung transplant may be the only option.
Although most cases of CF are associated with a genetic preposition, environment, lifestyle, and age are also 2 main factors that increase the risk of CF.
Cystic Fibrosis Canada in the investigation of the risk of CF in older adults wrote, "Today, the estimated median age of survival of CF patients in Canada is over 50 years, and the majority of patients are over 18 years of age. CF patients enjoy an improved quality of life, pursuing careers, and starting their own families".
Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
In finding a potential compound for the treatment of lung disease researchers examined the effects of carotenoids, the potent antioxidants on singlet oxygen and other toxic oxygen species in patients with cystic fibrosis (CF).
The study included a total of 17 patients with cystic fibrosis (CF) and 10 normal children,
According to the assessment of plasma levels of four carotenoids, beta-carotene, alpha-carotene, lutein, and lycopene, levels of carotenoids in children with CF were significantly lower compared to regular control participants.
There was no significant difference in total cholesterol and total carotene between groups. Furthermore, there was no correlation between fat absorption or measures of adiposity in children with CF compared to control.
However, levels of selected carotenoids were correlated negatively with serum IgG levels associated with the measurement of inflammation.
More importantly, researchers also found that the differences in plasma carotenoid levels between children with CF and normal children were involved in the rapid turnover of carotenoids, by quenching of toxic oxygen species in inflammatory states of CF.
The results strongly suggested that improving the concentration of carotenoids that reduces the implication of the toxic ROS expression may have an impact on the prevention and treatment of CF.
Intake of lycopene in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
Norton's
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Carotenoid levels in normal children and in children with cystic fibrosis by Homnick DN1, Cox JH, DeLoof MJ, Ringer TV. (PubMed)
(2) Living Longer WITH CYSTIC FIBROSIS by The Cystic Fibrosis Canada
#Healthyfood #Garlic Reduces the Risks and Complications of #CardiovascularDiseases, Researchers Suggest
By Kyle J. Norton
Cardiovascular diseases refer to heart diseases, affecting millions of people in the world. According to statistic, over 17.7 million people died from CVDs in 2015, Hyperlipidaemia and hypertension are the risk factors of the diseases.
There are many causes of heart disease. Anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease. Here are some early indications of heart disease symptoms:
Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.
A recent study suggested that garlic may be used for the prevention and treatment of heart disease.
According to Nihon University, organosulfur compounds found in garlic induce the functions of our body in attenuating the risk of cardiovascular diseases.
Dr. Kulczyński B, the lead author insisted that the effectiveness of garlic for the prevention and treatment of heart diseases probably is the result of the whole herb in the demonstration of their antioxidant, chemopreventive, anti-inflammatory and immunomodulatory properties.
Other researchers suggested the role of garlic in alleviating the risks of metabolic syndrome and cardiovascular complications is due to its modulatory effects on hyperglycemia, dyslipidemia and oxidative stress.
Garlic also has the potential to treat mild hypertension, decrease hypercholesterolemia, and prevent atherosclerosis, according to the joint study led by the Jordan University of Science and Technology,
Dr. Alali FQ, the lead author of the study also said, " Garlic (Allium sativum L.), a top-selling herbal dietary supplement, is renowned for its wide range of beneficial effects, particularly in the treatment and prevention of CVD".
In fact, data published after the year 2000 convincingly pointed out that garlic reduces the cardiovascular risk substantially, through inhibition of abnormal plasma lipids, oxidized low-density lipoproteins (LDL), abnormal platelet aggregation and high blood pressure.
Adding garlic into one diet may reduce the risk of the diseases if accompanied with the intake of more vegetables, fruits, and change of lifestyle.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Higher blood pressure as a risk factor for diseases other than stroke and ischemic heart disease by Kokubo Y1, Iwashima Y2.(PubMed)
(2) Effect of Garlic and Lemon Juice Mixture on Lipid Profile and Some Cardiovascular Risk Factors in People 30-60 Years Old with Moderate Hyperlipidaemia: A Randomized Clinical Trial by Aslani N1, Entezari MH1, Askari G2, Maghsoudi Z2, Maracy MR3.(PubMed)
(3) Prevention of Cardiovascular Diseases by Garlic-Derived Sulfur Compounds by Seki T1, Hosono T.(PubMed)
(4) Garlic (Allium sativum L.) and cardiovascular diseases by Ginter E1, Simko V.(PubMed)
(5) The importance of selected spices in cardiovascular diseases by Kulczyński B1, Gramza-Michałowska A1.(PubMed)
(6) Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats by Madkor HR1, Mansour SW, Ramadan G.(PubMed)
(7) Garlic for Cardiovascular Disease: Prevention or Treatment? by Alali FQ1, El-Elimat T2, Khalid L2, Hudaib R2, Al-Shehabi TS3, Eid AH4.(PubMed)
Cardiovascular diseases refer to heart diseases, affecting millions of people in the world. According to statistic, over 17.7 million people died from CVDs in 2015, Hyperlipidaemia and hypertension are the risk factors of the diseases.
There are many causes of heart disease. Anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease. Here are some early indications of heart disease symptoms:
Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.
A recent study suggested that garlic may be used for the prevention and treatment of heart disease.
According to Nihon University, organosulfur compounds found in garlic induce the functions of our body in attenuating the risk of cardiovascular diseases.
Dr. Kulczyński B, the lead author insisted that the effectiveness of garlic for the prevention and treatment of heart diseases probably is the result of the whole herb in the demonstration of their antioxidant, chemopreventive, anti-inflammatory and immunomodulatory properties.
Other researchers suggested the role of garlic in alleviating the risks of metabolic syndrome and cardiovascular complications is due to its modulatory effects on hyperglycemia, dyslipidemia and oxidative stress.
Garlic also has the potential to treat mild hypertension, decrease hypercholesterolemia, and prevent atherosclerosis, according to the joint study led by the Jordan University of Science and Technology,
Dr. Alali FQ, the lead author of the study also said, " Garlic (Allium sativum L.), a top-selling herbal dietary supplement, is renowned for its wide range of beneficial effects, particularly in the treatment and prevention of CVD".
In fact, data published after the year 2000 convincingly pointed out that garlic reduces the cardiovascular risk substantially, through inhibition of abnormal plasma lipids, oxidized low-density lipoproteins (LDL), abnormal platelet aggregation and high blood pressure.
Adding garlic into one diet may reduce the risk of the diseases if accompanied with the intake of more vegetables, fruits, and change of lifestyle.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Higher blood pressure as a risk factor for diseases other than stroke and ischemic heart disease by Kokubo Y1, Iwashima Y2.(PubMed)
(2) Effect of Garlic and Lemon Juice Mixture on Lipid Profile and Some Cardiovascular Risk Factors in People 30-60 Years Old with Moderate Hyperlipidaemia: A Randomized Clinical Trial by Aslani N1, Entezari MH1, Askari G2, Maghsoudi Z2, Maracy MR3.(PubMed)
(3) Prevention of Cardiovascular Diseases by Garlic-Derived Sulfur Compounds by Seki T1, Hosono T.(PubMed)
(4) Garlic (Allium sativum L.) and cardiovascular diseases by Ginter E1, Simko V.(PubMed)
(5) The importance of selected spices in cardiovascular diseases by Kulczyński B1, Gramza-Michałowska A1.(PubMed)
(6) Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats by Madkor HR1, Mansour SW, Ramadan G.(PubMed)
(7) Garlic for Cardiovascular Disease: Prevention or Treatment? by Alali FQ1, El-Elimat T2, Khalid L2, Hudaib R2, Al-Shehabi TS3, Eid AH4.(PubMed)
#Healthyfood #GreenPeas Exhibits Anti Cancer Activities, Researchers Suggest
By Kyle J. Norton
Cancer is a group of cell-mutated diseases caused by the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining of the tissue of an organ. At an early, most people with cancer are asymptomatic.
At the later stage, due to the size and the tumor, patients may experience general cancer symptoms such as unintended weight loss, fatigue, gastrointestinal discomfort, and loss of appetite, and localized symptoms such as severe pain and bleeding.
The exact causes of cancer are not identified. However, the most prevalent factors associated with cancer onset include age, family history, long-term exposure to certain cancer-induced chemicals, use of tobacco, and excessive alcohol drinking,..... the list goes on and on, depending on the type of cancer.
Some researchers suggested that the most common risk factor that causes cancer in the Western world may be associated with widespread obesity.
Dr. Karen Basen-Engquist, in the evaluation of the obesity risk of cancer, said, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%".
And, "High priorities for future research involve additional work on the underlying mechanisms, and trials to examine the effect of lifestyle behavior change and weight loss interventions on cancer and intermediate biomarkers".
The findings strongly indicated the risk of cancer is increased substantially in obese.
Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalayas Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.
In finding a potent ingredient for cancer treatment, researchers investigated the impact of green pea (GP) extracts anti-DNA alternative activity.
According to the studies,
* The extracts of P. sativum have been found to be pharmacologically active inducing anticancer effects.
* Compared to the effect of Bowman-Birk trypsin-chymotrypsin inhibitor, a potential cancer chemopreventive agent, with the protease inhibitors, rTl1B and rTl2B, P. sativum seed showed similar significant activity.
* In human colorectal adenocarcinoma HT-29, P. sativum extracted lectins from Egypt exhibited the antiproliferative property to liver cancer cell line.
* In MCF-7 (breast), HepG-2 (liver), HEP-2 (larynx), and HCT-116 (colon). an extracted lectin from the leaves and buds of P. sativum demonstrated cytotoxic properties.
* Recently, the seed extracts also showed cytotoxic effects on LS174 (colon), MDA-MB-453 (breast), A594 (lung), and K562 (blood) cell lines.
Taken altogether, green peas may be considered a functional food for the prevention of cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Pea, Pisum sativum, and Its Anticancer Activity by Runchana Rungruangmaitree and Wannee Jiraungkoorskul. (PMC)
Cancer is a group of cell-mutated diseases caused by the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining of the tissue of an organ. At an early, most people with cancer are asymptomatic.
At the later stage, due to the size and the tumor, patients may experience general cancer symptoms such as unintended weight loss, fatigue, gastrointestinal discomfort, and loss of appetite, and localized symptoms such as severe pain and bleeding.
The exact causes of cancer are not identified. However, the most prevalent factors associated with cancer onset include age, family history, long-term exposure to certain cancer-induced chemicals, use of tobacco, and excessive alcohol drinking,..... the list goes on and on, depending on the type of cancer.
Some researchers suggested that the most common risk factor that causes cancer in the Western world may be associated with widespread obesity.
Dr. Karen Basen-Engquist, in the evaluation of the obesity risk of cancer, said, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%".
And, "High priorities for future research involve additional work on the underlying mechanisms, and trials to examine the effect of lifestyle behavior change and weight loss interventions on cancer and intermediate biomarkers".
The findings strongly indicated the risk of cancer is increased substantially in obese.
Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalayas Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.
In finding a potent ingredient for cancer treatment, researchers investigated the impact of green pea (GP) extracts anti-DNA alternative activity.
According to the studies,
* The extracts of P. sativum have been found to be pharmacologically active inducing anticancer effects.
* Compared to the effect of Bowman-Birk trypsin-chymotrypsin inhibitor, a potential cancer chemopreventive agent, with the protease inhibitors, rTl1B and rTl2B, P. sativum seed showed similar significant activity.
* In human colorectal adenocarcinoma HT-29, P. sativum extracted lectins from Egypt exhibited the antiproliferative property to liver cancer cell line.
* In MCF-7 (breast), HepG-2 (liver), HEP-2 (larynx), and HCT-116 (colon). an extracted lectin from the leaves and buds of P. sativum demonstrated cytotoxic properties.
* Recently, the seed extracts also showed cytotoxic effects on LS174 (colon), MDA-MB-453 (breast), A594 (lung), and K562 (blood) cell lines.
Taken altogether, green peas may be considered a functional food for the prevention of cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Pea, Pisum sativum, and Its Anticancer Activity by Runchana Rungruangmaitree and Wannee Jiraungkoorskul. (PMC)
#Herbal #Turmeric Inhibits the Risk of #ChronicDiseases Associated with Inflammation, Researchers Say
By Kyle J. Norton
Inflammation is a process of the immune system that responds to harmful pathogens.
Inflammation can be acute or chronic. In the acute phase of infection, the immune system after receiving information from the neurons, macrophages, the largest white blood cells in the first line of defense stimulate the production of blood palette to cover the wound and the production of inflammatory cytokines to kill off micro-organisms, leading to symptoms of fever, redness, and swelling.
However, in some cases, the overproduction of proinflammatory cytokines may damage nearby healthy cells and tissues, causing the formation of scars.
In severe cases, a protein with duo functions in the production of pro and anti-inflammatory cytokines which produce anti-inflammatory cytokines under normal conditions also switch to produce pro-inflammatory cytokines.
Most cases of acute inflammation are resolved within a few days without causing damage to the wound tissues.
However, if the immune first line of defense can not completely destroy the invaders within a period of 3 to 8 weeks, it will compromise, leading to low-grade chronic inflammation.
Diseases associated with low-grade chronic inflammation include diabetes, cardiovascular disease, and cancer.
Dr. in the examination of the etiology of chronic inflammation (CI) suggested that CI can result from the following:
* Failure of eliminating the agent causing an acute inflammation such as infectious disease induced organisms
* Long-term exposure to a low level of particular irritant or foreign materials that cannot be eliminated by an enzymatic breakdown in the body including substances or industrial chemicals.
* An autoimmune disorder caused by the immune system that attacks healthy tissue, such as rheumatoid arthritis, systemic lupus erythematosus (SLE)
* Recurrent episodes of acute inflammation.
* Inflammation that causes oxidative stress and mitochondrial dysfunction such as advanced glycation end products (AGEs).
Conventionally, treatment of acute phase inflammation is to manage inflammation and prevent the risk of long-term damage, including anti-inflammatory nonsteroidal anti-inflammatory drugs (NSAIDs) which can be bought without a prescription.
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On findings a potential compound for the treatment of chronic diseases, researchers examined the efficacy of turmeric on continued oxidative stress and oxidative damage that lead to chronic inflammation in the mediation of most chronic diseases.
At the molecular level, turmeric showed a significant anti-inflammatory activity by suppressing the proteins associated with the production of pro-inflammatory cytokines, including the NF-κB and COX-2.
Furthermore, the proteins associated with the response to cytokines and growth factors such as signal transducer and activator of transcription 3 was also inhibited by the injection of turmeric.
Moreover, the administration of turmeric also inhibited the production of ROS by promoting the production of antioxidants enzymes such as nrf2, a protein that regulates the expression of antioxidant proteins that protect against oxidative damage.
Furthermore, numerous studies also indicated that curcumin not only is highly potent against antimicrobial disease but also inhibited the onset of various chronic diseases including cancers, diabetes, obesity, cardiovascular, pulmonary, neurological, and autoimmune diseases.
As of today, over 100 different clinical trials also showed that curcumin is safe, tolerable, and effective against various chronic diseases in humans.
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of chronic inflammatory diseases pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases by Kunnumakkara AB1, Bordoloi D1, Padmavathi G1, Monisha J1, Roy NK1, Prasad S2, Aggarwal BB. (PubMed)
(2) Curcumin, inflammation, and chronic diseases: how are they linked? by He Y1, Yue Y2, Zheng X3,4, Zhang K5, Chen S6, Du Z. (PubMed)
(3) Chronic Inflammation by Roma Pahwa; Ishwarlal Jialal. (NCBI)
Inflammation is a process of the immune system that responds to harmful pathogens.
Inflammation can be acute or chronic. In the acute phase of infection, the immune system after receiving information from the neurons, macrophages, the largest white blood cells in the first line of defense stimulate the production of blood palette to cover the wound and the production of inflammatory cytokines to kill off micro-organisms, leading to symptoms of fever, redness, and swelling.
However, in some cases, the overproduction of proinflammatory cytokines may damage nearby healthy cells and tissues, causing the formation of scars.
In severe cases, a protein with duo functions in the production of pro and anti-inflammatory cytokines which produce anti-inflammatory cytokines under normal conditions also switch to produce pro-inflammatory cytokines.
Most cases of acute inflammation are resolved within a few days without causing damage to the wound tissues.
However, if the immune first line of defense can not completely destroy the invaders within a period of 3 to 8 weeks, it will compromise, leading to low-grade chronic inflammation.
Diseases associated with low-grade chronic inflammation include diabetes, cardiovascular disease, and cancer.
Dr. in the examination of the etiology of chronic inflammation (CI) suggested that CI can result from the following:
* Failure of eliminating the agent causing an acute inflammation such as infectious disease induced organisms
* Long-term exposure to a low level of particular irritant or foreign materials that cannot be eliminated by an enzymatic breakdown in the body including substances or industrial chemicals.
* An autoimmune disorder caused by the immune system that attacks healthy tissue, such as rheumatoid arthritis, systemic lupus erythematosus (SLE)
* Recurrent episodes of acute inflammation.
* Inflammation that causes oxidative stress and mitochondrial dysfunction such as advanced glycation end products (AGEs).
Conventionally, treatment of acute phase inflammation is to manage inflammation and prevent the risk of long-term damage, including anti-inflammatory nonsteroidal anti-inflammatory drugs (NSAIDs) which can be bought without a prescription.
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On findings a potential compound for the treatment of chronic diseases, researchers examined the efficacy of turmeric on continued oxidative stress and oxidative damage that lead to chronic inflammation in the mediation of most chronic diseases.
At the molecular level, turmeric showed a significant anti-inflammatory activity by suppressing the proteins associated with the production of pro-inflammatory cytokines, including the NF-κB and COX-2.
Furthermore, the proteins associated with the response to cytokines and growth factors such as signal transducer and activator of transcription 3 was also inhibited by the injection of turmeric.
Moreover, the administration of turmeric also inhibited the production of ROS by promoting the production of antioxidants enzymes such as nrf2, a protein that regulates the expression of antioxidant proteins that protect against oxidative damage.
Furthermore, numerous studies also indicated that curcumin not only is highly potent against antimicrobial disease but also inhibited the onset of various chronic diseases including cancers, diabetes, obesity, cardiovascular, pulmonary, neurological, and autoimmune diseases.
As of today, over 100 different clinical trials also showed that curcumin is safe, tolerable, and effective against various chronic diseases in humans.
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of chronic inflammatory diseases pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases by Kunnumakkara AB1, Bordoloi D1, Padmavathi G1, Monisha J1, Roy NK1, Prasad S2, Aggarwal BB. (PubMed)
(2) Curcumin, inflammation, and chronic diseases: how are they linked? by He Y1, Yue Y2, Zheng X3,4, Zhang K5, Chen S6, Du Z. (PubMed)
(3) Chronic Inflammation by Roma Pahwa; Ishwarlal Jialal. (NCBI)
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