Herbal Turmeric Protects the Endocrine Function Naturally

By Kyle J. Norton

Scientists may have found a bioactive ingredient which protects the endocrine system integrity with no side effects, according to studies.

The endocrine system is made up of glands that produce and secrete hormones with an aim to regulate the activity of cells or organs.

In other words, the endocrine system produces hormones to regulate the body's growth, metabolism (the physical and chemical processes of the body), and sexual development and function.

Any disruption of the endocrine system can cause abnormal production of the hormones, leading to developmental malformations in the infant and children, interference with the function of the reproductive organ, increased cancer risk; and disturbances in the immune and nervous system function.

The most common cause of endocrine dysfunction is exposure to men-make xenochemiclas. Particularly to those new and without testing men make chemicals introduced to the market every year.

There are many ways that endocrine disruptors can interfere with the endocrine system in hormone production such as mimic or partly mimic naturally occurring hormones in the body like estrogens such as xanophytochemicals that bind to a receptor within a cell and block the endogenous hormone from binding.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a natural ingredient which promotes the endocrine function, researchers examined the effects of ginger and turmeric on the modulation of hormone production of the body glands.

According to the differentiation of physiological and therapeutic effects of ginger and turmeric, both exerted a significant activity in some endocrine gland functions, and signal pathways by 

* Inhibiting the high levels of some hormones such as T4, leptin or interacting with hormone receptors. In other words, ginger and turmeric normalize the levels of the hormone for the body needs.

* Inhibiting the production of cytokines/adipokine expression associated with inflammation and oxidative stress.

* Inhibiting the levels of reactive oxygen species (ROS)-generating enzymes against the oxidative stress induced hormone imbalance.

* Protecting the cell integrity against DNA alternation by promoting pro-apoptotic and inhibiting proliferative genes.

The results strongly suggested that ginger and curcumin exerted strong protection of endocrine functioning by modulating the hormones produced by the glands.

Based on the findings, researchers said, "These multiple mechanisms of protection against inflammation and oxidative damage make ginger and curcumin particularly promising natural agents in fighting the ravages of aging and degenerative diseases".

Taken altogether, turmeric combined with ginger may be considered supplements for the prevention and treatment of endocrine dysfunction, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Physiological and therapeutical roles of ginger and turmeric on endocrine functions by Al-Suhaimi EA1, Al-Riziza NA, Al-Essa RA. (PubMed)
(2) [Effect of 5 warm-hot nature Chinese drugs for promoting blood circulation and removing blood stasis on 5-HT, NE, and endocrine hormones of rats of cold coagulation and blood stasis syndrome].[Article in Chinese] by Wang P1, Fu XJ, Zhou Y, Wang ZG. (PubMed)

3,3'-Diindolylmethane Suppresses the Progression of Non-alcoholic Steatohepatitis (NASH)

By Kyle J. Norton


Non-alcoholic steatohepatitis (NASH) is an advanced form of inflammatory non-alcoholic fatty liver disease (NAFLD) caused by a buildup of fat in the liver.

NASH has been found to induce the formation of scars of the liver, a leading cause of cirrhosis associated with the onset of liver cancer and liver failure.

The progression of NASH has been a leading cause of liver transplant.

Patients with NASH are asymptomatic. However, some patients may experience vague pain and discomfort in the abdomen.

The causes of NAFLD are identified. Some researchers suspected that long-term unhealthy diet accompanied by physical inactivity may have a strong impact in accelerating the onset of the disease.

Dr. Kristen Stephenson in the investigation of the western diet in the risk NAFLD, wrote, "Nonalcoholic fatty liver disease (NAFLD) is a disease of increasing interest, as its prevalence is on the rise. NAFLD has been linked to metabolic syndrome, which is becoming more common due to the Western diet".

And, "WD mouse models consisting of high fat, cholesterol, and a combination of high-fructose corn syrup, sucrose, fructose, or glucose not only lead to metabolic syndrome but also induce NAFLD".

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

On finding the natural ingredient for the treatment of nonalcoholic steatohepatitis (NASH), researchers at the joint investigation led by the Fudan University examined the effects of 3, 3'-diindolylmethane (DIM) on methionine-choline-deficient (MCD)-diet induced mouse nonalcoholic steatohepatitis (NASH).

NASH mice were administrated with or without DIM at different concentrations for 8 weeks 

In vivo, DIM treatment alleviated hepatic steatosis and inflammation and restored the Treg/Th17 imbalance from MCD diet-induced Th17 dominance to Treg dominance.

In-vitro, instead of suppressing the expression of Th17m, DIM not only significantly promoted the expression of the mRNAs that purify spleen CD4(+) T cells, but also enhanced the immunosuppressive function of these Treg cells.

In MCD-diet mice, DIM significantly exhibited the function of CYP1A1 and CYP1B1 in metabolizing liver toxicity, whereas down-regulated those of TLR4 on CD4(+) T cells in the promotion of autoimmune inflammation, leading to Treg/Th17 imbalance.

In other words, DIM treated NASH by dramatical induction of Treg dominance to alleviate intra-hepatic inflammation.

Dr. Liu Y, the lead scientist wrote, "dietary cruciferous vegetables (containing abundant DIM) might exist as a protective factor for patients with NASH-related liver diseases".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of nonalcoholic steatohepatitis (NASH), pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3, 3'-Diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance by Liu Y1, She W1, Wang F1, Li J2, Wang J1, Jiang W. (PubMed)
(2) Updates on Dietary Models of Nonalcoholic Fatty Liver Disease: Current Studies and Insights by Kristen Stephenson,* 1 Lindsey Kennedy,†‡ 1 Laura Hargrove,‡ Jennifer Demieville,†Joanne Thomson,† Gianfranco Alpini,*†‡ and Heather Francis. (PMC)

Herbal Bilberry Improves Your Lipoprotein Parameters in Human Trials

By Kyle J. Norton

The lipoprotein profiles or lipoprotein parameters are a general term comprised the traditional lipoprotein profile include total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyceride.

Total cholesterol is the total amount of cholesterol in your blood, including the low-density lipoprotein (LDL, or “bad”) cholesterol and high-density lipoprotein (HDL, or “good”) cholesterol. 

The healthy ratio of blood cholesterol is less than 4 of the low-density lipoprotein to 1 of high-density lipoprotein.

Where low-density lipoprotein is produced by the liver or from food sources needed for the cells to build strong membranes, produce steroid hormones, vitamin D and bile to aid the digestive system in absorbing nutrients and fluids.

And high-density lipoprotein produced by the liver or from the external sources needed to return the low-density lipoprotein back to the liver.

Triglycerides, an important measure of heart health is the fat in the blood caused by the over-consumption of foods containing fat, carbohydrates, and simple sugars.

Factors that affect your lipoprotein profiles can be unpreventable including age, gender, race, and genetic preposition and preventable such as diet, weight, physical activity, and smoking.

Some researchers suggested that people who are obese are at a substantially higher risk of poor lipoprotein profiles.

Dr. Pandolfi C, the lead scientist wrote, "Lipid pattern has resulted in overlapping both in the two studied populations and in the two subgroups of pre- and postmenopausal women, while greater concentrations of Lp(a), (p < 0.001) and t-PA (p < 0.05) have been found in obese populations vs controls".

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belongings to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

In the urgency on finding natural sources of the plant-based compound for the prevention of cardiovascular disease (CVD), researchers investigated regular consumption of bilberries in CVD risk reduction.

Women (n=25) and men (n=11) selected to the study received 150 g of frozen stored bilberries 3 times a week for 6 weeks. All parameters associated with the risk CVD were measured by standard assays.

In both sexes, the consumption of bilberries led to a decrease in the parameters of lipoprotein profiles, including total cholesterol, LDL-C, TG, and a positive increase in HDL-C.

However, in men, additionally, favorable changes were observed in total cholesterol (P=.004), reduced oxidative stress and HDL-C, but increase in LDL-C compared to women group.

In other words, the regular intake of bilberries can be important to reduce CVD risk, by promoting a decrease of  LDL-C/TG and increase of HDL-C.

Furthermore, in order to reveal more information about bilberry against CVD risk, researchers compared consumed dried sea buckthorn berries (SBs), sea buckthorn oil (SBo), sea buckthorn phenolics ethanol extract mixed with maltodextrin (SBe+MD, 1:1), or frozen bilberries on metabolic profiles.

In a total of 80 women selected to complete this randomized crossover study for 30 d, all interventions induced a significant effect on the overall metabolic profiles, particularly in lipid parameters observed both in participants who had a metabolic profile that reflected higher cardiometabolic risk at baseline (group B) and in participants who had a lower-risk profile (group A).

However, bilberries treatment group caused beneficial changes in serum lipids and lipoproteins in group B, whereas the opposite was true in group A.

The finding clearly suggested bilberries modulated the parameters of lipids and lipoproteins depending on the risk of CVD.

Dr. Larmo PS, after taking into account of co and confounders wrote, "Berry intake has overall metabolic effects, which depend on the cardiometabolic risk profile at baseline (including bilberry)".

Taken altogether, bilberry may be considered a functional remedy for the promotion of lipid-protein profiles in reducing the risk of CVD, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovasculardisease by inducing favorable changes in lipoprotein profiles by Habanova M1, Saraiva JA2, Haban M3, Schwarzova M4, Chlebo P5, Predna L6, Gažo J7, Wyka J. (PubMed)
(2) Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial by Larmo PS1, Kangas AJ, Soininen P, Lehtonen HM, Suomela JP, Yang B, Viikari J, Ala-Korpela M, Kallio HP. (PubMed)
(3) [Lipoprotein(a), parameters of lipid metabolism and hemostasis in obese patients].[Article in Italian] by Pandolfi C1, Pellegrini L, Dedè A, Lo Vecchio M, Mercantini F. (PubMed)

Phytochemical Betalains, the Anti-Lipid Oxidation Bioactive Compound

By Kyle J. Norton

Lipid oxidation is a condition of oxidative lipid generation.

In other words, the molecule in the lipid has an unpaired electron in the outer ring.

Free radicals are unstable atoms which have an unpaired electron in the outer most ring. In order to become stable, they must donate or intercept an electron from other stable atoms, leading to a chain reaction that can not be stopped until all electrons in the outer ring are paired or inhibited by antioxidants.

Overexpression of free radicals caused by depletion of antioxidant enzymes produced by the host body has been found epidemiologically inducing protein and lipid damage and alternation of cell DNA in facilitating the risk of chronic diseases.

In the examined the pathology of neurological disorders, some researchers suggested that lipid oxidation in the brain may induce neurological disease due to the vulnerability of the central nervous system for reactive oxygen species-mediated injury.

Precisely, the risk of neuro damaged by lipid oxidation is greatest in the brain because the neurons consume large amounts of oxygen, areas containing high iron content, and neuronal mitochondria generate large amounts of hydrogen peroxide, particularly the neuronal membranes are rich in polyunsaturated fatty acids.

Out of many risk factors that induced lipid oxidation in the body, some researchers suggested that the promotion of a high-fat diet over the past few decades may be one of the major cause of diseases associated with the condition.

Dr. Schrauwen P, the lead scientist wrote, " Twenty-four-hour fat oxidation gradually increased on the high-fat diet. Both at rest and during exercise, there was no change in the rate of appearance of fatty acids and plasma-derived fatty acid oxidation. Triglyceride-derived fatty acid oxidation tended to be higher after 7 days of high-fat diet at rest (P < 0.07)".

And, "the results from this study suggest that triglyceride-derived fatty acid oxidation (VLDL or intramuscular triglycerides) plays a role in the increase in fat oxidation on a high-fat diet, but plasma-derived fatty acids remain the major source for fat oxidation".

The findings strongly suggested people with the weakened immune system and low levels of antioxidant due to aging is vulnerable to lipid oxidation induced neuro-degenerative disease.

Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a potential ingredient against hyperlipidemia, researchers evaluated the bioavailability of betalains from dietary sources.

The study included 8 healthy volunteers (n = 8) with a single ingestion of 500 g cactus pear fruit pulp, which provided 28 and 16 mg indicaxanthin and betalain, respectively.

According to the first-order kinetics, betanin and indicaxanthin reached their maximum plasma concentrations 3 h after the fruit meal and declined and disappeared from plasma by 12 h after intake.

Thes results suggested that betalain are biologically unstable.

Betalains at concentrations of 100.5 +/- 11 and 50 +/- 7.2 pmol/mg showed a significant effect in protecting the LDL protein against oxidation.

Compared to the samples isolated before fruit ingestion, the higher amounts of betalains showed the higher the resistance against injury caused by lipid oxidation.

In other words, the higher amount of betalains in the blood demonstrated higher protection against tissues damage due to oxidative stress.

Based on the findings, Dr. the lead scientist wrote in the final report, "cactus pear fruit is a source of bioavailable betalains and suggests that indicaxanthin and betanin may be involved in the observed protection of LDL against ex vivo-induced oxidative modifications".

Taken altogether, betanin may be considered supplements for the prevention and treatment of tissues damage caused by lipid oxidation, pending to the confirmation of larger sample size and multicenter human study.


Intake of betalains in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Absorption, excretion, and distribution of dietary antioxidant betalains in LDLs: potential health effects of betalains in humans by Tesoriere L1, Allegra M, Butera D, Livrea MA. (PubMed)
(2) The role of lipid peroxidation in neurological disorders by Mototada Shichiri. (PMC)
(3) Increase in fat oxidation on a high-fat diet is accompanied by an increase in triglyceride-derived fatty acid oxidation by Schrauwen P1, Wagenmakers AJ, van Marken Lichtenbelt WD, Saris WH, Westerterp KR. (PubMed)

Herbal Ginger, A Potent Remedy for the Treatment Alzheimer's disease (AD) in Vivo

By Kyle J. Norton

Scientists may have found a natural aal ingredient used in every kitchen for the treatment of Alzheimer's disease (AD), according to studies.

Alzheimer's disease is a progressive disease caused the gradual loss of the neurons in the affected area.

People with AD  experience of symptoms of memory, thinking, and behavior severe enough to affect language communication, memory, lifelong hobbies or social life. The severity of symptoms is totally depending on the stage of the disease.

Without proper treatment, Alzheimer's disease can get worse over time, and it is fatal.

According to the statistic, over 1 million people in the US alone are currently afflicted by Alzheimer's disease caused by the generation of the hippocampus and cerebral cortex of the brain where memory, language, and cognition located.

With this mental disorder, brain cells gradually die and generate fewer and fewer chemical signals day by day, leading to diminished functions.

As of today, there is no known cure. Most treatment is to interfere with the progression and improve the quality of the disease in people in the early stage.

Although there are many risk factor associated with the disease onset. However, in the examination of the median age of patients diagnosed with AD. Some researchers suggested that the increase in age may be one of the major risk factors that cause Alzheimer's disease.

Dr. Raymond Y. Lo, said, "Alzheimer's disease (AD) has become a global health issue as the population ages. There is no effective treatment to protect against its occurrence or progression. Some argue that the lack of treatment response is due to delays in diagnosis. By the time a diagnosis of AD is made, neurodegenerative changes are at the stage where very few neurons can be salvaged by medication".

And, " The paradigm of dementia care policy may shift to early diagnosis of AD pathology and comprehensive care for chronic diseases in the elderly population".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of Alzheimer's disease (AD) with no side effects investigated the methanolic extract of dry ginger (GE) anti AD through the antioxidant activity, cholinesterase inhibition, anti-amyloidogenic potential, and neuroprotective properties.

The extracts used for the study included18 +/- 0.6 mg/g gallic acid equivalents of total phenolic content and 4.18 +/- 0.69 mg quercetin equivalents/g of dry material.

GE expressed high antioxidant activity with an IC50 value of 70 +/- 0.304 microg/mL, through reducing the expression of neuro oxidative stress in the initiation of AD.

According to the Ellman's assay, GE had an IC50 value of 41 +/- 1.2 microg/mL and 52 +/- 2 microg/mL for inhibition of acetyl- and butyrylcholinesterase association with the formation of β-amyloid (Aβ) plaques, respectively.

Also, GE increased the cell survival against amyloid beta (Abeta) induced toxicity in primary adult rat hippocampal cell culture.

Furthermore, GE effectively prevented the formation of Abeta oligomers and dissociated the preformed oligomers.

Based on the results, Dr. Mathew M, the lead scientist said, "Methanolic GE influences multiple therapeutic molecular targets of AD".

In order to provide more information about the ginger anti incidence of AD, researchers assessed the ability of a traditional Chinese medicinal ginger root extract (GRE) to prevent behavioral dysfunction in the Alzheimer disease (AD) rat model.

Rat AD models used for the study were treated with a one-time intra-cerebroventricular injection of amyloid β-protein (Aβ) and continuous gavage of aluminum chloride every day for 4 weeks before GRE was administered intragastrically.

At day 35, The significant memory deficits were shorter in the group that received OP with a high dose of GRE (HG)(OP+HG) than in the groups that received OP with a low or moderate dose of GRE (LG, MG)(OP+LG, OP+MG).

High dose of GRE (HG)(OP+HG) injection also increased the expression of antioxidant enzymes produced by the host such as superoxide dismutase (SOD) and catalase (CAT) compared to the OP+HG groups (p<0.05).

Also, rat treated high dose of GRE (HG)(OP+HG) also showed reduced levels of pro-inflammatory cytokines and oxidative stress marker.

Dr. Zeng GF, the lead scientist wrote in the final report, "This experiment demonstrates that the administration of GRE reverses behavioral dysfunction and prevents AD-like symptoms in our rat model".

Take all together, ginger processed a high amount of bioactive compounds may be considered a function alternative for the prevention and treatment of AD, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) In vitro evaluation of anti-Alzheimer effects of dry ginger (Zingiber officinale Roscoe) extract by Mathew M, Subramanian S. (PubMed)
(1) Protective effects of ginger root extract on Alzheimer disease-induced behavioral dysfunction in rats by Zeng GF1, Zhang ZY, Lu L, Xiao DQ, Zong SH, He JM. (PubMed)
(3) The borderland between normal aging and dementia by Raymond Y. Lo. (PMC)

Whole Food Tomato Protects Your Heart Against Cardiovascular Diseases,

By Kyle J. Norton

Cardiovascular disease is a group of conditions involved in blood vessels and heart.

In the Western world, most cases of CVD are related to a process called atherosclerosis, a condition associated with plagues build-up on the wall of arteries that reduces the oxygen-rich blood flow to the heart in facilitating the onset of heart disease and stroke, depending to the affected location.

Heart disease is the condition caused by the plaques disruption that has induced significant heart muscle damage, leading to heart disease associated with symptoms 

* Leg cramps during walking 

Leg cramps during walking might be an indication of heart disease caused by arteries in your leg being clogged up by cholesterol in the result of not enough oxygen being delivered to the cells in your leg. If this symptom persists, please consult with your doctor.

* Chest pain
Chest pain is caused by blood vessels in the heart temporarily being blocked up by inadequate oxygen supply to the heart muscle. The persistence of chest pain would be an early indication of heart diseases.

* Shortness of breath
Shortness of breath (dyspnea) is the major symptom of the left ventricular insufficiency. People with shortness of breath are four times more likely to die from a heart disease-related cause than individuals without any symptoms.

* Headaches
People see sparkling zigzag lines or loss of vision before a migraine attack may be at particular risk of future cardiovascular problems. Generally, headaches do not cause heart diseases but a sudden, explosive onset of great pain might be.

* Dizziness
Dizziness can have many causes including low blood count, low iron in the bloodstream and other blood disorders, dehydration, and viral illnesses. Since there are many different conditions that can produce these symptoms, anybody experiencing episodes of severe headaches or dizziness ought to be checked by your doctor.

* Palpitations
Palpitations is an extremely common symptom of heart disease. Palpitations are the skips in the heart beats and irregular heartbeats.

* Loss of consciousness
It is a common symptom, most people pass out at least once in their lives. However, sometimes loss of consciousness indicates a dangerous or even life-threatening condition such as heart disease so when the loss of consciousness occurs it is important to figure out the cause.

Stroke is a condition caused either by the reduced blood or rupture of a blood vessel depriving oxygen in the blood that induces the death of neurons.

Symptoms of a stroke attack can be

* Sudden trouble in standing
Sudden trouble in standing is an early symptom of stroke as a result of the circulation of blood that carries oxygen to the brain suddenly deplete caused by narrowing of arteries and high blood pressure.

* Dizziness and loss of balance
The brain coordinates information from the eyes, the inner ear, and the body's sense to maintain balance. If the cells of that part of the brain get damaged in the result of depleted oxygen will cause dizziness and loss of balance.

* Sudden confusion
Sudden onset of confusion means that something is potentially going wrong with the brain. Almost all conditions that affect the brain are life-threatening. 

* Having trouble speaking and understanding
Having trouble speaking and understanding occurs when the brain cells in the area of the Broca, Wernicke and angular gyrus in the left hemisphere area begin to die.

*Sudden severe headaches
Headache is a condition of pain in the head, sometimes neck or upper back pain may also be affected. It ranks amongst the most common local pain complaints and may be frequent for many people but sudden severe headaches may be caused by an early symptom of stroke due to the rupture of a brain vessel or depletion of oxygen in some parts of the brain.

* Sudden trouble seeing
This may be an early indication of stroke when the oxygen in the blood supply to the part of the brain is suddenly interrupted, affecting the cells that control the vision area of the cerebral cortex in the brain.

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to discover healthy foods for the treatment of cardiovascular disease (CVD), researchers examined the effect of consuming tomato products and lycopene on markers of cardiovascular (CV) function.

By searching 3 databases including Medline, Web of science, and Scopus from inception to August 2016, researchers identified 21 fulfilled inclusion criteria included in the meta-analyses.

All publication showed that the interventions supplementing tomato were associated with significant reductions in LDL-cholesterol, production of proinflammatory cytokine I(L-6), and improvements in flow-mediated dilation (FMD).

Compared to tomato, lycopene supplementation reduced systolic-BP (-5.66 mmHg; p = 0.002) without affecting other outcomes significantly.

Based on the results, Dr. Cheng HM, the lead scientist wrote, "The available evidence on the effects of tomato products and lycopene supplementation on CV risk factors supports the view that increasing the intake of these has positive effects on blood lipids, blood pressure, and endothelial function".

In other words, tomatoes processed a potential effect in the inhibition of CVD developing.

In other to review more information about tomato and its bioactive compound lycopene anti CVD activity, researchers examined the clinical trials comparing the efficacy of lycopene supplements with tomato products on intermediate CVD risk factors.

According to the results from the clinical trial, consuming tomato-based foods as a first-line approach to cardiovascular health.

However, compared to the supplement lycopene in blood pressure management, tomato intake provided more favorable results on cardiovascular risk endpoints than did lycopene supplementation.

Taken altogether, tomato processed a high amount of lycopene may be considered a dietary supplements for the prevention and treatment of CVD, pending to large sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis by Cheng HM1, Koutsidis G1, Lodge JK1, Ashor A2, Siervo M2, Lara J. (PubMed)
(2) Whole food versus supplement: comparing the clinical evidence of tomato intake and lycopene supplementation on cardiovascular risk factors by Burton-Freeman B, Sesso HD. (PubMed)
(3) Heart Diseases- Causes, Symptoms, Types, Preventions & Treatments by Kyle J. Norton
(4) Stroke - Causes, Symptoms The Risk Factors, Types, Preventions and Treatments by Kyle J. Norton

Cucumber and Bioactive Compound Cucurbitacins, The Best Neuroprotective Agents

Kyle J. Norton

The central nervous system containing the brain and the spinal cord is the complex system of nerve tissues that controls the activities of the human body.

It is the center that controls our thoughts, the interpreter of our external environment, and the body movement.

Neuroprotection is an action, including the use of substances such as herbal medicines to protect our bain against the loss and death of neurons.

Believe it or not, diseases associated with CNS are including

* Brain and spinal cord trauma, a type of condition can lead paralysis to mood disorders, depending on the location of the injury.

*CNS Infections caused by micro-organisms and viruses can lead as is meningitis and malaria. 

*Disease associated with neuro-degeneration, include Alzheimer's disease and Parkinson's disease.

* Diseases associated with birth defects include anencephaly.

* Brain tumors caused by abnormal cell growth in the brain or metastases by primary cancer from other tissues and organ.

* Autoimmune disorders caused by the immune system that attacks mistakenly the brain and spinal cord cells.

* Stroke caused the death of neuron due to the reduced blood supply to the brain.

However, out of many risk factors involved in the onset of neurodegenerative disease, some researchers suggested that the promotion of a high-fat diet may be the major culprit that causes the rise of the incidence in the Western world.

Dr. the lead scientist wrote, "This increase in glial responses was associated with increased plaque burden in the hippocampus. Interestingly, given recent studies highlighting the importance of TREM2 in microglia/monocytes in AD susceptibility and progression, B6 and APP/PS1 mice fed the western diet showed significant increases TREM2+ microglia/monocytes". 

And, " Therefore, an increase in TREM2+ microglia/monocytes may underlie the increased risk from a western diet to age-related neurodegenerative diseases such as Alzheimer’s disease".

On finding a potential ingredient which processes neuroprotective effect researchers evaluated the protective effect of Cucumis melo var. flexuosus (C. Melo var. flexuosus) leaf extract on the brains of diabetic rats.

The study included dietetic male albino rats induced by a single intraperitoneal injection of streptozotocin (STZ; 60 mg/kg bw).divided into 5 groups of 6 rats each, a normal control group and four diabetic groups.

Additionally, 3/4 other groups were treated with C. Melo var. flexuosus (cucumber) leaf extract at the doses of 30, 60 and 120 mg/kg bw for a period of 30 days compared to nontreatment of a diabetic group.

Compared to non treated diabetic rats, treated rat protected the brain neurons by markedly increasing the plasma dopamine, melatonin, brain vascular endothelial growth factor-A levels, particularly the antioxidant activity in the brain tissues.

In other words, cucumber leaf extract processes neuroprotective effect by preventing neurons oxidative damage associated with diabetes.


Based on the results, Dr. Ibrahim DS, at the Benha University wrote, " it can be concluded that the C. Melo var. flexuosus leaf extract exerts a neuroprotective effect against oxidative damage associated with diabetes".

In order to reveal more information about cucumber neuroprotective property, researchers examined the effect of Cucurbitacins (CuB), a major bioactive compound from cucumber on neuroinflammatory responses are involved in the neuronal injury.


According to the tested results, pretreatment with Cucurbitacins significantly reduced the production of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6 iNOS and COX-2 expression) in microglia, a type of neuroglia (glial cell) located throughout the brain and spinal cord.


Furthermore, CuB also inhibited the proteins and pathways associated with the stimulation of immune response in the activated production of inflammation.

Moreover, the neuroprotective of CuB was also attributed to the bioactive compound in the activation of (Nrf2/ARE pathway) pathways involved in significantly greater resistance to oxidative stress and protein associated with the production of antioxidants and anti-inflammatory cytokines.


Dr. Park SY, the lead scientist said, "Cucurbitacins is a potent activator of the Nrf2/ARE pathway and is therapeutically relevant not only to neuroinflammatory responses of microglia but also neuroinflammation mediated neuronal injury".

Taken altogether, cucumber processed high levels of CuB may be considered a neuroprotective remedy, pending to the confirmation of the larger sample size and multicenter human study.


Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Neuroprotective effect of Cucumis melo Var. flexuosus leaf extract on the brains of rats with streptozotocin-induced diabetes by Ibrahim DS. (PubMed)
(2) Cucurbitacins attenuate microglial activation and protect from neuroinflammatory injury through Nrf2/ARE activation and STAT/NF-κB inhibition by Park SY1, Kim YH1, Park G2. (PubMed)
(3) Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease by Leah C. Graham,1,2 Jeffrey M. Harder,1 Ileana Soto,1 Wilhelmine N. de Vries,1,3Simon W. M. John,1,2,3,4 and Gareth R. Howella. (PMC)