Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Friday 31 August 2018

Beet, A Potent Veggie Which Kills Skin Cancer Cells in Vivo and Vitro

By Kyle J. Norton

Beet, or beet root may have a therapeutic potential in inhibited onset of skin cancer, some scientists suggested.

Skin caner is a medical condition characterized by abnormal skin cell growth in disordered and uncontrollable ways.

Skin cancer is still a major cause of morbidity and mortality in US. According to statistic provided by Skin Cancer Foundation, approximately, 5.4 million cases of nonmelanoma skin cancer were treated in over 3.3 million people in the U.S, in 2012.

Noticeably, 1 in 5 Americans will develop skin cancer by the age of 70.

According to general belief, the major cause of skin cancer is accumulative sun exposure. However, most people do not know, accumulative sun exposure during the childhood also plays an important role in increased risk of skin cancer in adulthood.

Truly, occupation chemical exposure, aging and ethnicity are prevalent risk of skin cancer onset.

People with genetic or acquired genetic mutation gene such as NLRP1 may also associated to substantially increased risk of skin cancer(4).

The Singapore Institute of Molecular and Cellular Biology in joint study, wrote,"a group of non-fever inflammasome disorders, uncover an unexpected auto-inhibitory function for the pyrin domain, and provide the first genetic evidence linking NLRP1 to skin inflammatory syndromes and skin cancer predisposition".

Beet, best known as the beetroot or garden beet and belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.

Beet with high amount of organic nitrate may have a profound effect on risk factor and treatment of skin cancer.

According to the Howard University, in the analysis of beet root, anti skin cancer effect in vivo, measurement from bioassays, beet root has a chemo preventive effect in expressed a significant inhibition on skin tumors of tested mice.

In skin tumor initiation by 390 nmol of 7,12-dimethylbenz(a)anthracene (DMBA) in 100 microl of acetone together with mouse skin tumor promotion with 3430 J/m(2) of ultraviolet light-B (UV-B), researchers found that administration of 0.0025% and topical application of 390 nmol of betanin, the major chemical constituent isolated from beet root, reveal a strong protection in the mouse skin cancer model.

Beside skin cancer, betanin, a regularly consumed natural product colorant found abundance in beet root may also be effective chemopreventive agent in treating other types of cancer , such as lung and liver cancers.

Other in the validated sugar beet pectin/gelatin hydrogels, in vivo, conjunction with anti cancer chemodrug, doxorubicin, demonstrated a successfully suppressed growth of a solid tumor created by applied to skin of mouse melanoma B16F1 cells into nude mice.

The findings reveal that beet, with high amounts of nitrate may be used as therapeutic and functional food in attenuated risk and treatment of skin cancer alone or combined with other chemoagents.

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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Chemoprevention of lung and skin cancer by Beta vulgaris (beet) root extract by Kapadia GJ1, Tokuda H, Konoshima T, Nishino H.(PubMed)
(2) Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skincarcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot by Kapadia GJ1, Azuine MA, Sridhar R, Okuda Y, Tsuruta A, Ichiishi E, Mukainake T, Takasaki M, Konoshima T, Nishino H, Tokuda H.(PubMed)
(3) Injectable and biodegradable sugar beet pectin/gelatin hydrogels for biomedical applications by Takei T1, Sugihara K, Yoshida M, Kawakami K.(PubMed)
(4) Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation by Zhong FL1, Mamaï O2, Sborgi L3, Boussofara L4, Hopkins R5, Robinson K6, Szeverényi I6, Takeichi T7, Balaji R6, Lau A6, Tye H8, Roy K6, Bonnard C6, Ahl PJ5, Jones LA5, Baker PJ8, Lacina L6, Otsuka A9, Fournie PR10, Malecaze F10, Lane EB6, Akiyama M11, Kabashima K12, Connolly JE5, Masters SL8, Soler VJ10, Omar SS13, McGrath JA14, Nedelcu R15, Gribaa M16, Denguezli M4, Saad A16, Hiller S3, Reversade B(PubMed)

Thursday 30 August 2018

Green Tea, A Healthy Beverage That Inhibits Aging Expression of Seborrheic Keratoses

Kyle J. Norton

Green tea may have a therapeutic and positive effect in treatment of seborrheic keratosis , some scientists suggested.

Seborrheic keratosis is a common skin disorder in older adults with appearance a brown, black or light tan growth on the face, chest, shoulders or back.

Although the disorder is painless and required no treatment, the seborrheic keratosis may annoy some people if they develop in the face areas.

The causes of Seborrheic Keratoses are not known. However, some researchers suggested, prolonged sun exposure may play a role in stimulated onset of the condition..

Luckily, Seborrheic keratoses are not contagious.

Aging and family history also are prevalent risk factors of the skin disease onset.

Green tea, is a precious drink processed numbers of health benefit known to almost everyone in Asia and Western world.

In the examine the exposure of skin to a variety of environmental, chemical, and genotoxic agents that contribute to skin disease and carcinogenesis, researchers found that

* Sun ultraviolet light (UVR) is considered as the main external stress in the induction of skin disorder including seborrheic keratoses through promoting immunosuppression, oxidative stress, premature aging,...... and

*Application of green tea polyphenols protects the skin of the body against such expressions by exhibiting significant antioxidant, chemopreventive, and immunomodulatory effects.

Further analysis of the effect of skin damage induced by ultraviolet (UV) radiation in animal models of 30 BALB/c mice randomly divided into 3 groups:

* Control group ( mice), without UVB exposure and green tea administration;

*. Exposure group ( mice), which were exposed to UVB light only; and

*. Treatment group ( mice), which were exposed to UVB light and treated with 1 mL of green tea through oral gavage.

After 4 days/week of UVB irradiation (20 minutes/day, 4 weeks), researchers indicated that oral administration of green tea exerted a significant photo-protection against UVB induced hyperplasia, an indication of abnormal cell proliferation.

These results suggested that green tea has had a strong implication of in ameliorated risk of skin disorders in the induction of overgrowth of abnormal cell and skin cell damage caused by prolonged UVB exposure, including seborrheic keratoses.

More importantly, although sun-exposed and non-sun-exposed skin, cumulative exposure to sunlight and aging have been proposed as independent risk factors for their development of seborrheic keratoses, however, in gene expression, researchers found that mutation of protein PTEN may have a strong impact the expression of seborrheic keratoses.

Phosphatase and tensin homolog (PTEN) is a protein with function in signaling the making a tumor suppressor enzyme in regulating cell division.

Mutation of PTEN was a risk factor for the development of many types of cancer.

Some researchers in the investigation of UVB exposure against skin diseases to healthy individual suggested that UVB induced expression of seborrheic keratoses by downgraded PTEN expression.

In other words, exposure to UVB in reduced function of PTEN or mutation of protein PTEN expressed a strong effect in promoted seborrheic keratoses development.

Truly, according to the study with all animal procedures approved by the Institutional Animal Care and Use Committee at the University of Chicago, to compare the tumor formation in the skin between mice with normal PTEN ( þ / þ ) and mice with PTEN hemizygosity, researchers once again confirmed that deleted one allele of the Pten gene in the epidermal keratinocytes causes the formation of tumors resembling human seborrheic keratoses(SKs) as well as of squamous cell carcinomas (SCCs)(3).

According to the University of Regensburg, genetic mutation such as FGFR3 mutations is associated with the pathogenesis of at least a subset of seborrheic keratoses.

Increased age also is also a risk factor of FGFR3 mutations.

Taken together, Green tea and its bioactive polyphenols may have a therapeutic effect in attenuated development of seborrheic keratoses induced by overexpression UVB or UVB in reduced function of Phosphatase and Tensin homolog (PTEN) or PTEN protein mutation,

Sources
(1) Role of Green Tea in Reducing Epidermal Thickness upon Ultraviolet Light-B Injury in BALB/c Mice(Hindawi)
(2) UVA Induces Lesions Resembling Seborrheic Keratoses in Mice with Keratinocyte-Specific PTEN Down-Regulation by Mei Ming,1 Christopher R. Shea,1 Li Feng,2 Keyoumars Soltani,1 and Yu-Ying He1(PMC)
(3) FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization by Hafner C1, Hartmann A, van Oers JM, Stoehr R, Zwarthoff EC, Hofstaedter F, Landthaler M, Vogt T.(PubMed)

Wednesday 29 August 2018

Carrot, The Root Vegetable Promotes Cytoprotective Effect In Prevented Onset of Chronic Diseases, Scientists Say

Kyle J. Norton

Carrots may have a profound and positive effect in reduced over expression reactive oxygen species that cause chronic diseases, through antioxidant activities, some scientists suggested.

Antioxidant is a substance characterized by its function in inhibited oxidation, especially in balanced the ratio of free radicals and antioxidant levels in the body to prevent the initiation of oxidatively related diseases.

Chronic diseases are conditions that last longer than 3 months and can not cure by medication.
The diseases are most common in aging population.

Most common chronic diseases are arthritis, cardiovascular disease such as heart attacks and stroke. Cancer such as breast and colon cancer, diabetes.

Sadly, in North America, the most common chronic disease is obesity, affecting over 28% of general population.. In other words, 1 in 3 adults are obese, according to calculation by BMI index.

The causes of chronic diseases are well established by epidemiological studies. There are a set of risk facts including unhealthy diet, physical inactivity,.... and tobacco use that induce preventable chronic illness through intermediate risk factors such as high blood pressure, and glucose levels, abnormal blood lipids, overweight and obesity.

The major non modifiable risk factors that also cause chronic diseases are age and heredity.

Dr. George E. Hardy, Jr, the lead scientist in the study of "The Burden of Chronic Disease: The Future is Prevention" wrote, "Chronic diseases impose an enormous financial and societal burden on the United States. According to the Centers for Disease Control and Prevention (CDC), chronic diseases today account for 70% of the deaths of all Americans and 75% of this country’s annual health care costs" and More importantly, "Unless we take steps now to deal effectively with chronic diseases, our nation is headed for a serious financial and quality-of-life crisis"(4).

Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

The efficacy of carrot acted as an antioxidant to protect against oxidation was reported by numbers of institution including the Texas A&M University and University of Messina.

According to the investigation of phenolic antioxidants in three carrots cultivars (Navajo, Legend and Choctaw) were studied under different wounding intensities (A/W) during storage, researchers found that carrot soluble phenolics exert a significant antioxidant capacity (AOX), and PAL activity in protect against increased with A/W for all cultivars.

In Intense wounding (23.5 cm(2)/g) induced an ∼2.5- and ∼12.4-fold displayed a strong in increased production of soluble phenolics and AOX, respectively, after 4 days in compared to whole and lesser wound carrots through the AOX synthesis of mainly chlorogenic acid (5-CQA) and 3,5-dicaffeoylquinic acid.

These results suggested that intentional carrot wound may have a potential effect as an inexpensive rich source of phenolic antioxidants for the regular diet (with some resistances from public), as Dr. Surjadinata BB, the lead author said, " By simply increasing wounding stress intensity, it is possible to enhance the biosynthesis of phenolic antioxidants".

Moreover, according to the investigation of the polyphenolic profile and biological properties of a black carrot crude extract (BCCE) through an in-depth analysis of the main polyphenolic effect in antioxidant and cytoprotective properties.

Black carrot (Daucus carota L. ssp. sativus var. atrorubens Alef.) is a valuable source of carbohydrates, minerals and vitamins.

The root vegetable contains also high amounts of anthocyanins in expression of the characteristic of deep-purple color.

Anthocyanins are known as natural dyes used in the food and pharmaceutical industry.

According to the experiment, application of black carrot crude extract (BCCE) demonstrated a strong antioxidant through free radical scavenging activity, observed in the hydrogen transfer-based assays (ORAC and β-carotene bleaching) and a significant increase in the cell viability.

The increase in the cell viability may be attributed to the extract in stimulated production of antioxidants of itself and antioxidants found in the body tissue of the host in inhibited the over expression of ROS, resulting in balancing the antioxidants and free radical ratio.

Furthermore, BCCE exhibited a strong anti-angiogenic activity against free radical in alternated DNA of healthy cells in initiation of tumor proliferation, at the highest concentration assayed on the chick chorioallantoic membrane (50μg/egg).

Interestingly, ingestion of black carrot crude extract (BCCE) also promoted cytoprotective effect against ROS in causing healthy cell damage and apoptosis.

The analysis of above studies was supported by the joint investigation of purple carrot (PC) as a valuable source of antioxidants in modulated the reactive oxygen species (ROS) level in the gastrointestinal tract conducted by numbers of institutes, lead by the Poznań University of Life Sciences.

According to the end experiment, application of purple carrot (PC) showed a strong effect in inhibited colonic cells in situ after allowing passage to the gastrointestinal tract.

At dose of 1mg/mL, purple carrot exhibited intracellular ROS-inhibitory capacity observed by 18.4% decreased expression of reactive oxygen species ROS.

Moreover, at inhibited rate of 20.7%, the extract demonstrated a significantly protective effect against free radicals in damage to the DNA of colon mucosa cells.

After taking account of other con founders and re-examine the final results, Dr.Olejnik A, the lead scientist said, "PC extract is capable of colonic cells' protection against the adverse effects of oxidative stress".

Taken together, Carrot regardless to color with abundant bioactive phytochemicals may be considered as functional food in reduced risk, progression and treatment of oxidative induced chronic diseases.

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Biosynthesis of phenolic antioxidants in carrot tissue increases with wounding intensity by Surjadinata BB1, Cisneros-Zevallos L.(PubMed)
(2) Polyphenolic profile and biological activities of black carrot crude extract (Daucus carota L. ssp. sativus var. atrorubens Alef.) by Smeriglio A1, Denaro M1, Barreca D1, D'Angelo V1, Germanò MP2, Trombetta D1.(PubMed)
(3) Antioxidant effects of gastrointestinal digested purple carrot extract on the human cells of colonic mucosa by Olejnik A1, Rychlik J2, Kidoń M3, Czapski J3, Kowalska K2, Juzwa W2, Olkowicz M2, Dembczyński R2, Moyer MP4.(PubMed)
(4) The Burden of Chronic Disease: The Future is Prevention Introduction to Dr. James Marks' presentation, “The Burden of Chronic Disease and the Future of Public Health” by George E. Hardy, Jr., MD, MPH, Executive Director(PMC)

Green Tea Extract EGCG, A Novel Topical Ingredient for Cold Sore, Scientists Found

Kyle J. Norton

Green tea may have a therapeutic and positive effect in reduced risk and and treatment of cold sore (herpes simplex labialis infection), some scientists suggested.

Cold sore is common skin disease characterized by tiny blisters that develop on the lips or around the mouth caused by the infection of herpes simplex virus strain HSV-1 mostly.

Believe or not, over 80% of North American population have herpes 1 virus living permanently in their body without causing any health problem. However, the dormant virus can quickly multiple to affect the skin in the lips if the immune system is weakened or triggered by certain conditions such as prolonged stress, digestive disorder.

The virus is very contagious, anyone who comes to direct contact with infected person can easily be infected.

Most common symptoms of cold sore include sensations, tingling,,...... pain, or numbness on the lip and skin surround the lip.

Cold sore that appears inside the mouth may be troublesome, as the condition interferes with food injection and speech.

In numbers of severe case, herpes 1 virus may infect the eye, brain, leading to vision loss and certain brain infectious diseases.

Conventional anti viral medicine used for treatment of cold sore may be effective such as Zovirax, Famvir,..... and valacyclovir, but they can induce certain side effects including digestive discomforts,..., headache, dizziness,.... and tiredness.

In the reaffirmed the efficacy of atechins from the tea plant (Camellia sinensis) therapeutic effect on herpes simplex virus infections in vitro and in vivo, researchers conducted a double-blind, placebo-controlled, randomized trial with 40 participants.

The aim of the joint study is to clinically evaluate a topical proprietary formulation containing lipophilic catechins (AverTeaX, Camellix, LLC, Evans, GA, USA) on recurrent herpes labialis.

In compared to vehicle group treated with 100% glycerin USP, CVS Pharmacies, Inc., Woonsocket, RI, USA), topical application of AverTeaX applied six to eight times daily showed a strong reduction in clinical episode duration (median 4.5 days vs. 9 days) and shortened blistering and ulceration stages within an episode from a median of 3 days to 1 day.

According to the median quality-of-life scores, AverTeaX treated group demonstrated in respect to duration of itching, from a median of 4 days to 1 day, and duration until symptom free, from a median of 8 days to 4 days.

Interestingly, both groups displayed a similar in median scores for itching, pain, burning, swelling, bleeding, and stress.

No adverse effects were found in both groups, during the term of study.

Based on these results, Dr. Zhao M, after taking into account of other co founders, said, "AverTeaX formulation containing lipophilic catechins effectively inhibited herpes simplex labialis infection with clinical significance".

Additionally, in further analysis to address the green tea extract in reduced expression of HSV in precipitated risk of skin infection, including cold sore and reconfirmed EGCG anti-oxidant activity in inhibited number of plaques in HIV-infected cultured cells, a study to evaluate the efficacy of modified EGCG palmitoyl-EGCG (p-EGCG), as a topical antiviral agent for Herpes Simplex Virus (HSV-1) infections was conducted.

p-EGCG is not toxic to cultured Vero cells, according to the cell viability and cell proliferation assays

According to the results, application of p-EGCG increased the effectiveness of EGCG as an antiviral agent.

In compared to EGCG topically applied to skin, one of the primary tissues infected by HSV, green tea polyphenol epigallocatechin gallate (EGCG) with palmitate was a more potent inhibitor of Herpes Simplex Virus 1 (HSV-1).

Observation of other assays used in the experiment, p-EGCG concentrations of 50 µM or higher exerted linearly in blocking the production of infectious HSV-1 particles.

These efficacy suggested that p-EGCG may be considered as potent and natural ingredient in inhibited HSV-1 adsorption to Vero cells.

Thus, p-EGCG may provide a novel treatment for HSV-1 infections, including cold sore.

The findings suggested that topically green tea used combination of other herbal ingredients or green tea extract used alone may have a therapeutic potential in treatment of cold sore caused by herpes simplex virus HSV-1 infection)

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Topical lipophilic epigallocatechin-3-gallate on herpes labialis: a phase II clinical trial of AverTeaX formula by Zhao M1, Zheng R1, Jiang J1, Dickinson D2, Fu B1, Chu TC3, Lee LH4, Pearl H5, Hsu S6.(PubMed)
(2) Inhibition of Herpes Simplex Virus type 1 with the modified green tea polyphenol palmitoyl-epigallocatechin gallate by Aline de Oliveira,a Sandra D. Adams,b Lee H. Lee,b Sean R. Murray,c Stephen D. Hsu,d Jeffrey R. Hammond,cDouglas Dickinson,d Ping Chen,e and Tin-Chun Chua(PMC)

Caffeinated Coffee, The Beverage Which Protects Cells Integrity Against Genotoxicity, Biomedical Literature Reveal

By Kyle J. Norton

Coffee and coffee caffeine may have a profound and positive effect in reduced risk of genotoxicity, caused by environmental toxins, a coffee production company opinionated.

Genotoxicity is an action that causes alternation of cell DNA due to overwhelming toxins accumulated in the cells. In most cases, the alteration affects the cells integrity, leading to cancers.

Substances such as radiation and chemicals that cause genotoxicity are called genotoxins.

Highly genotoxic chemicals include the known potent carcinogens benzo(a)pyrene, aflatoxin B1, N-nitroso compounds, and various alkylating agents that directly act on DNA, inducing breakage and cross-linking, and the formation of DNA adducts, abasic sites, oxidative damage, alkylation, and various other DNA lesions(4).

Interestingly, some genotoxins do not directly act on DNA but cause numerical chromosome aberrations during cell division(4).

Furthermore, certain chemicals used in pesticides, food additives, starches, shampoos, and fireproof and crease-proof fabrics may be considered as genotoxins as they also cause genetic mutations.

Moreover, automobile exhaust fumes and medicine used for their antibacterial activity and in chemotherapy(5), chemicals from occupational sources and tobacco may also induce mutations and cancer(6).

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

In rat liver and primary hepatocytes, regular intake of coffee daily illustrated an enormous effect in cellular antioxidant defenses through regulating exhibited enzymes involved mRNA and protein expression.

The study also suggested that coffee and coffee caffeine through the expression of detoxifying enzymes GSTs and AKR(in cellular detoxification) also demonstrate significant activities in reduced risk of genotoxicity and cytotoxicity caused by injection of aflatoxin B1 (AFB1).

Dr. Cavin C, the lead author said, " the coffee-mediated stimulation of the Nrf2-ARE pathway resulting in increased endogenous defense mechanisms against electrophilic but also oxidative insults further support that coffee may be associated with a protection against various types of chemical stresses".
(Please note that the Nrf2-ARE pathway is an indicator and modulator of oxidative stress)

Other, in the evaluated L5178Y mouse lymphoma cell line to assess the modulatory effects of coffee against genotoxicity induced by N-methyl-N-nitro-N-nitrosoguanidine (MNNG), researchers found that
* 3 doses of instant coffee caffeine injection displayed a decrease in genotoxicity following co-treatment of mouse lymphoma cells.

* Coffee caffeine pre-treatment or co-treatment exhibited significant antigenotoxic effects against MNNG(an environmental carcinogen that causes DNA mutation) expression.

* Both caffeinated and decaffeinated instant coffee demonstrated a similar effect against genotoxicity in the experiment samples.

Dr. Abraham SK, the lead authors said, " Results from three or five independent experiments demonstrated significant protective effects of caffeinated instant coffee against MNNG-induced DNA damage in the comet assay, a mutation at the Tk locus and chromosomal damage in the cytokinesis-block micronucleus test".

In support of the above analysis, the Swiss Federal Institute of Technology (ETH), in the study of protective effects of coffee against somatic mutation and mitotic recombination induced by chemo drugs, cyclophosphamide (CPH), mitomycin C (MMC) and urethane (URE), using standard (ST) and high bioactivation (HB) crosses of the wing spot test in Drosophila melanogaster assays, suggested that in dose depending, coffee injection showed a strong effect in the genotoxicity of URE in the ST and the genetically susceptible HB cross as well as the genotoxicity caused by MMC application.

Dr. Abraham SK, the lead researcher said, "The magnitude of the protective effects of coffee against these three genotoxins was independent of the genotype of the larvae used for treatment, that is it was independent of the bioactivation capacity of these larvae".

The collective information showed a definitive support of coffee and coffee caffeine used as functional food in reduced risk against genotoxic expression, including side effects of chemo medicine used in the treatment of multi types of cancers.

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How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver by Cavin C1, Marin-Kuan M, Langouët S, Bezençon C, Guignard G, Verguet C, Piguet D, Holzhäuser D, Cornaz R, Schilter B.(PubMed)
(2) Anti-genotoxicity of coffee against N-methyl-N-nitro-N-nitrosoguanidine in mouse lymphoma cells by Abraham SK1, Stopper H.(PubMed)
(3) Protection by coffee against somatic genotoxicity in Drosophila: role of bioactivation capacity by Abraham SK1, Graf U.(PubMed)
(4) Thresholds of Toxicological Concern for Genotoxic Impurities in Pharmaceuticals by Masamitsu Honma
(5) Structure−Activity Relationship Studies of Chemical Mutagens and Carcinogens: Mechanistic Investigations and Prediction Approaches by Romualdo Benigni
(6) Aromatic amines and cancer by Vineis P1, Pirastu R.(PubMed)

Fennel Seed Extracts That Gobble Up Toxins Caused by Medication Toxicity, Scientists Show

Kyle J. Norton

Fennel seeds may have a potential to act as liver antitoxins enzymes in removed xenobiotics from our body, some scientists suggested.

Liver cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme, mainly found in the liver with function in stimulating the removal of toxins from our body through the oxidation of small foreign organic molecules (xenobiotics).

Acute drug toxicity is a condition characterized by having too much of a drug in the body at once caused by overdoses of a certain medicine.

Otherwise, drugs toxicity is a condition of toxin accumulation caused by long-term intake of medicine which has a strong and negative impact on the liver or kidneys enzymes that are responsible for toxin removals.

The signs and symptoms of toxicity differ depending on the medication. However, most common symptoms may include diarrhea, dizziness, nausea, stomach pains, vomiting, and weakness.

Untreated drug toxicity may induce complications of ataxia, muscle twitches, slurred speech, nystagmus, seizures, coma,....... and, in rare cases, heart problems and death.

Dr. ALASDAIR BRECKENRIDGE, in the article " A clinical pharmacologist's view of drug toxicity" wrote, "Our ability to understand the basis of adverse drug reactions has improved progressively, and with it, the ability to prevent their occurrence; one aim of the clinical pharmacologist is to identify patients at special risk" and " With a fair degree of certainty one can also predict that advances in bioinformatics, genomics, and combinatorial chemistry will progressively contribute to clinical toxicology in the future"(6).

Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean

The herb or food has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

In the study to compare the effectiveness of herbal compounds isolated from fennel against toxins that mediated by human liver cytochrome P450 3A4, researchers found that 13 compounds process a strong inhibitory activity(1).
Among these compounds, 5-methoxypsoralen (5-MoP) showed the strongest inhibition of toxins induced by drug interaction with an IC50 value of 18.3 μm and with a mixed type of inhibition(1).

According to the Brescia University Hospital, 5-methoxypsoralen (5-MOP) may be considered an alternative to 8-methoxypsoralen (8-MOP) for photochemotherapy of psoriasis, proven by the study in compared the clinical efficacy and tolerability of 5-MOP (1.2 mg/kg)-UVA versus 8-MOP (0.6 mg/kg)-UVA therapy in 25 patients of skin type III and IV(5).

The University of Toyama conducted an experiment to examine whether methanolic extract of fennel showed a characteristic of mechanism-based inactivation on erythromycin N-demethylation mediated by human liver microsomal cytochrome P450 3A4 (CYP3A4), suggested, 5-methoxypsoralen (5-MOP) showed the strongest inhibition with an IC50 value of 18.3 microM and a mixed type of inhibition, similar to those of above study.

With the preincubation time of 20 min only, 5-MOP showed preincubation time dependency with the IC50 value decreased from 18.3 microM with a preincubation time of 0 min to 4.6 microM with a preincubation time of 20 min(2).

These results suggested that 5-MOP acts as a human Liver Cytochrome P450 3A4 in inhibition of toxins caused by drugs interaction in time-dependent manner.

Additionally, in the examine the antitoxic effect of 30 sample plants of Indonesia, caused by injection of xenobiotics, researchers showed that methanol extracts isolated from fennel seed exerted time-dependent inhibition toxins oxidized similarly to those of cytochrome P450 3A4 (CYP3A4) and CYP2D6.

In comparing the experimental injection to another plant with the same volume, fennel seeds extract should contain mechanism-based inhibitors on CYP3A4.

Mechanism-based inhibition or suicide inhibition, also known as suicide inactivation is an irreversible form of enzyme inhibition. If you need more information about the definition, please click the link provided by the Evidence Based Medicine

Taken together, fennel and fennel seeds extract may be considered as a functional supplement in protect liver detoxed enzymes against overexpression of toxins caused by small foreign organic molecules.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator by Subehan1, Zaidi SF, Kadota S, Tezuka Y(PubMed)
(3) Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants by Subehan1, Usia T, Iwata H, Kadota S, Tezuka Y.(PubMed)
(4) Antimicrobial and P450 Inhibitory Properties of Common Functional Foods by San Nguyen1 , Huang Huang2 , Brian C. Foster1,3, Teresa W. Tam1 , Tim Xing2 , Myron L. Smith2 , John T. Arnason1 , Humayoun Akhtar(J Pharm Pharm Sci (www.cspsCanada.org) 17(2) 254 - 265, 2014)
(5) A reappraisal of the use of 5-methoxypsoralen in the therapy of psoriasis by Calzavara-Pinton P1, Ortel B, Carlino A, Honigsmann H, De Panfilis G(PubMed)
(6) A clinical pharmacologist's view of drug toxicity by ALASDAIR BRECKENRIDGE(PMC)

Tuesday 28 August 2018

*Black (Dried, Common) Bean, The Legume That Promotes Weight Loss

Kyle J. Norton(Scholar, Master of Nutrition, all right reserved)

Black or common bean with abundant fiber may be considered as function foods in induced weight loss of obese and overweight subjects, some scientists suggested.

Weight loss is a decrease of body weight regardless to circumstances. However, healthy weight loss is a gradual weight reduction through exercise, change of diet and lifestyle without affecting the nutrients intake.

Losing weight is not easy, and it takes commitment. Even 5% or 10% of weight loss may have a significant effect in improved your health. A step-by-step guide is also necessary get you on the right track.

The CDC said,, " if you weigh 200 pounds, a 5 percent weight loss equals 10 pounds, bringing your weight down to 190 pounds. While this weight may still be in the “overweight” or “obese” range, this modest weight loss can decrease your risk factors for chronic diseases related to obesity"(5).

Some researchers suggested over weight and obesity are associated to increase risk of short and long term health problems.

According to the National Institutes of Diabetes and Digestive and Kidney Diseases, overweight and obesity are associated to compilations of type 2 diabetes, high blood pressure, heart disease, and strokes,..... and certain types of cancer.

The BMI can be helpful tool to determine whether you are underweight, normal weight, overweight, or obesity.

* Under weight if MBI is less than 18.5
* Normal weight if BMI is in the range from 18.5 to 24.9
* Overweight: if BMI is in the range from 25 to 29.9
* Obesity if BMI is 30 or higher

According to statistic, approximately, over 68% of Amerrican are either over weight or obesity.
and Americans spent over $60 billion a year to purchase diet programs and products.

Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can bought in most grocery stores all around the year in dried and canned forms.

It is believed that black bean was first domesticated growth in South America.

In the review of literature data base, researchers at the University of Exeter found that injection of black bean exerted a statistically significant weight loss through reduction of body fat in compared placebo groups(1).

In the study of dried bean in reduced risk of cardiovascular disease in obese subjects, researchers found that black bean fed Sprague-Dawley rats and diet-induced obesity model in C57Bl/6 mice treated groups experienced significant weight loss through improved plasma lipid profile within a 12 d time frame.

Dr. Zhu Z, the lead author said, "These findings support the use of short-term (7-14 d) assays to investigate mechanisms that account for the cardioprotective and weight regulatory effects of dry bean and to screen dry bean germplasm resources for types of bean with high protective activity'(2).

In fact, a review literature obtained from the electronic databases PubMed, SpringerLink, Google Scholar, ScienceDirect, and MEDLINE with full text (via EBSCOHost) during late 2012 - early January 2013, showed that botanical ingredients from part of Phaseolus vulgaris and extract isolated from plants exhibited a potentially promising therapeutic effects in appetite controlled and weight loss.

Indeed, intake of high amount of dietary fiber has showed statistically significant benefits for reduction of body weight and rick factor in developed complication, such as gallstones.

Taking together, black bean, a the common bean species hold a potential value in weigh loss and weight management through expression of appetite controlled and prevented weight loss induced complications.

However, further studies are necessary to determine the magnitude of the effects, optimal dosage, mechanisms of action, long term safety, and potential side effects of crude extracts.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton(Scholar, Master of Nutrition, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The efficacy of Phaseolus vulgaris as a weight-loss supplement: a systematic review and meta-analysis of randomised clinical trials by Onakpoya I1, Aldaas S, Terry R, Ernst E.(PubMed)
(2) Edible dry bean consumption (Phaseolus vulgaris L.) modulates cardiovascular risk factors and diet-induced obesity in rats and mice by Zhu Z1, Jiang W, Thompson HJ.(PubMed)
(3) A review on botanical species and chemical compounds with appetite suppressing properties for body weight control by Astell KJ1, Mathai ML, Su XQ.(PubMed)
(4) Dietary fiber's benefit for gallstone disease prevention during rapid weight loss in obese patients by Sulaberidze G1, Okujava M1, Liluashvili K1, Tughushi M1, Bezarashvili S1.(PubMed)
(5) Health Risks of Being Overweight by NIH