Thursday 12 July 2018

Beware of These Symptoms of Perforated Appendicitis, A Life Threatening Condition

By Kyle J. Norton, Scholar, Master of Nutrition

Appendicitis is a condition of inflammation of appendix.

The condition is classified as an emergency, in many incidences, required the removal of the appendix. 

Early diagnosis is easily treated with 100% recovery.

If burst, or perforate, spilling infectious materials into the abdominal cavity can be life threatening.
And depending to each patients condition, treatment of appendicitis perforate, may opt for conservative treatment by means of an intravenous antibiotic therapy to solve acute abdomen pain, planning a routinary interval appendectomy (IA) after some months or an immediate appendectomy(4).

Examples are quoted directly from the joint study led by the Institute for Maternal and Child Health - IRCCS Burlo Garofolo
[Patient 1. immediate appendectomy

This 5-year old girl showed the following symptoms: 5 days fever, abdominal pain and vomit. Leukocytes and PCR was 18 × 103 and 16 (mg/dl) respectively.

US showed a perforated appendicitis associated with an inflammatory mass.

We decided to perform an immediate video-assisted appendectomy through a subumbilical incision for the laparoscopic operative trocar insertion.

We found a subhepatic necrotic appendix surrounded by an abscess.

To dissect and extract the appendix, it was necessary to enlarge the subumbilical incision and create a second access in the left iliac fossa. Nasogastric tube (NT) and vesical catheter (VC) were placed. Surgery time was 165 min.

Oral feeding started on day 4. Hospital stay was 9 days.

She was treated with a triple antibiotic therapy (ampicillin/sulbactam 50 mg/kg every 8 h, metronidazole 10 mg/kg every 8 h, tobramycin 5 mg/kg in a single dose) for 9 days.

In the postoperative stage, an infection of the subumbilical wound was observed.


Patient 2: immediate appendectomy
This 4-year old girl reported having abdominal pain and fever for 3 days. Leukocytes and PCR was 24 × 103 and 20 mg/dl respectively.

US showed a thickening of the appendix with a pericecal effusion without a secure image of abscess.

An immediate video-assisted appendectomy was performed through a single enlarged subumbilical incision.

We found a necrotic appendix with an inflammatory mass involving the right tube and ovary.

The tube wall was very fragile and during the procedure a tubal lesion led to a partial tube removal. NT and VC were placed. Surgery time as 70 min.

Oral feeding started on day 3. Hospital stay was 10 days. Our standard triple antibiotic therapy was continued for 10 days.

In the postoperative stage, a subumbilical wound infection was observed](4).


Dr. Edoardo Guida and colleagues said, " In the case of a perforated appendicitis with an abscess and coprolith is an initial conservative case management followed by a routine interval appendectomy performed not later than 4 months after discharge"(4).

Therefore, to rule out perforated appendicitis, you must understand the signs and symptoms of below and act accordingly


1. Abdominal pain and upper respiratory tract infection
Although appendicitis is the condition that most commonly requires emergent abdominal surgery in the paediatric population, less than 2% of the disease occurs in infants and it is even more uncommon in neonates. 

There is report of a rare case of a 14-month-old child presenting with abdominal pain first diagnosed with upper respiratory tract infection and then admitted to Paediatric Surgery Department with a final diagnosis of acute appendicitis, according to the FONDAZIONE IRCCS CA’ GRANDA – Ospedale Maggiore Policlinico(1).

2.  Symptoms of  vomiting, fever, pain, anorexia, diarrhea, abdominal tenderness, peritonitis, temperature 38.0 degrees C or more, abdominal distension, Leukocytosis, small-bowel obstruction (SBO), contrast enemas and perforated appendicitis.

According to some researchers, if you experience of all these symptoms persistently over 3 days or more, you may be in the early stage of  appendicitis. Please check with your doctors right the way.

In the study to identify the presenting symptoms and signs in this age group and examine their subsequent management and outcome, by the The Scarborough Hospital, indicated that in 27 children less than 3 years old (mean 23 months) comprised 2.3% of all children with appendicitis in the series, the most common presenting symptoms were vomiting (27), fever (23), pain (21), anorexia (15), and diarrhea (11).

The average duration of symptoms was 3 days, with 4 or more days in 9 children. Eighteen children were seen by a physician before the correct diagnosis was made; 14 were initially treated for an upper respiratory tract infection, otitis media, or a urinary tract infection.


The most common presenting signs were abdominal tenderness (27), peritonitis (24), temperature 38.0 degrees C or more (21), abdominal distension (18), Leukocytosis (<12.0 x 10(3)/mm(3)) was found in 18, tenderness was localized to the right lower quadrant (RLQ) in 14 and was diffuse in 10.

 Abdominal radiographs demonstrated findings of a small-bowel obstruction (SBO) in 14 of 21 patients, a fecalith in 2, and a pneumoperitoneum in 1. Contrast enemas were performed in 6 children, 5 of whom had a phlegmon or an abscess. Perforated appendicitis was found in all 27 patients. An appendectomy was performed in 25 and a RLQ drain was placed in 18(2).

3. An abdominal mass, guarding, rebound tenderness, rigidity, diffuse or focal tenderness, diarrhea, emesis, fever, pain, and anorexia
According to the Children's Hospital of Philadelphia, the common physical signs of an abdominal mass, guarding, rebound tenderness, rigidity, and diffuse or focal tenderness and common symptoms are diarrhea, emesis, fever, pain, and anorexia with the most common presenting symptom was abdominal pain (94%); the most common sign was abdominal tenderness (95.8%)(3).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Tuesday 10 July 2018

Infectious Diseases: The Natural Remedies That Inhibit Over Growth of Candida, Scientists Say

By Kyle J. Norton, Scholar, Master of Nutrition

Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.

Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).

According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.

Herbal medicine or phytotherapy is a traditional practice used botany and plants for treatment of a variety of diseases.

Today, due to serious side effects caused by intake of conventional single ingredient medication, some scientists once again have looked into herbal whole food plant with an aim to find the replacements with similar effectiveness without inducing adverse effect.

These journeys have encountered many problems, as the discovery of such plants will provide no commercial benefit and patent right to producers. Particularly, if such plants are found, they will exert a major blow in cutting into sizable benefits of big pharmaceutical companies

Truly, between 25 to 50% of current pharmaceuticals derived from plants, none are used as antimicrobials(b).

Some researchers suggested that duplicated herbal successes of Western drugs with the synthetic version for patent right without using the whole herb ingredients for commercial profits may eventually contribute to over expression of serious adverse effects(b).

Imbalance of ratio of ROS species and antioxidant enzemes in the host tissue have played an essential role in initiated expression of healthy cell cytotoxicity that can alternate DNA strascription in facilitated the development of of chronic ailments such as over growth of candida.

In free radical over expression cause of over growth candida, certain natural alternatives exerted a strong antioxidant effect that target Candida.

According to Dr. Seneviratne CJ at the University of Hong Kong, in the study of "Potent anti-raditional Chinese herbal plant contains significant and potent antifungal activities, such as Rhizoma Coptidis and Cortex phellodendri Chinesis on three different non-albicans Candida species, C. glabrata, C. krusei and C. tropicalis(a).

The Anti Over Growth of Candida Natural Alternatives

1. Manuka Honey
Manuka honey has been known to benefit humans in healing wounds and injuries(309) without inducing damage to cells. The product also contains hydrogen peroxide claimed to have antimicrobial property(310), including candida albicans(311).

2. Undecylenic acid
Undecylenic acid is the common name of the 10-undecenoic acid, an organic unsaturated fatty acid derived from castor oil, It is a natural antimicrobial property(312)against fungal skin infections(313)(314) and Candida albicans(315).

3. Caprylic acid
Caprylic acid is the common name for the eight-carbon saturated fatty acid found naturally in coconuts and breast milk, used in treatments for a variety of conditions, including Candida(316)(317).

4. Echinacea angustifolia
Echinacea angustifolia is a herbaceous plant species Echinacea angustifolia, belongings to the family Asteraceae native to Northern America. Echinacea angustifolia besides enhances the immune system function(318)(319) against invasion of bacteria and viral through its antioxidant effects, it also used to treat bacterial infections(320) and candida(318) in herb medicine.

5. Horopeito
Horopeit is a genus Pseudowintera, part of family Winteraceae. The herb contains a compound polygodial, a chemical compound used to suppress the growth of candida(321)(322) by damaging the permeable cell membrane of yeast(322).

6. Oregano
Oregano is a genus of the mint family Lamiaceae, native to southwestern Eurasia and the Mediterranean region. The herb not only promotes digestive health(323), clear skin and healthy immune system(324), but also dehydrates candida(325) by reacting with the water in the bloodstream, through its phytochemicals Carvacrol and Thymol(326).

7. Aloe vera
Aloe vera is a genus Aloe belongings to the family Asphodelaceae, originated in the Sudan. Beside containing significant amounts of amino acids, enzymes, vitamins, minerals and antioxidants which help to enhance the immune function(327) in fighting against virus and bacteria infection and inflammation(328), it also maintains a proper PH levels that inhibit the growth of candida(329) and repairs and seals the intestinal wall, which stops Candida from actually penetrating through and into your blood stream(330).

8. Tea tree oil
Tea tree oil is a pale yellow color to nearly clear essential oil extracted from the leaves of the Narrow-leaved Tea-tree, native to the northeast coast of New South Wales, Australia. In Fluconazole-resistant candidaalbicans strains, dose-depend manner, tea tree oil strongly exhibited fluconazole activity against fluconazole-resistant C. albicans strains, through its anti fungal activity(331).

Terpinen-4-ol, the main bioactive component found in teat tree oil, also showed to accelerate clearance all Candida strains from the vagina , including the azole-resistant forms in rat vaginal infection model(332)

9. Tannate plant extracts
Tannate is the salt or ester of tannic acid. Tannate plant extract is a powerful anti fungal agent(333)(334) by destroying candida selectively without harming the good flora in the body(335). It is said that tannate plant extract is effective in treating bacteria, viruses, fungal infections due to its antifungal(333)(334), anti-inflammatory properties(336).

10. Biotin
Biotin or viyamin B7, a coenzyme in the metabolism of fatty acids and leucine, plays an important role in gluconeogenesis(337). According to Università degli Studi di Torino, patients with biotin deficiency are at high risk of candida albicans overgrowth(338).

Biotin prevents yeast to change into its fungal form(339), thus reducing risk of candida albicans overgrowth.

11. Probiotics (friendly bacteria)
Probiotic is live microorganisms which benefits the host. Intake of probiotics enhances the production of hydrogen peroxide(340) that plays a important role in preventing candida overgrowth and through self-multiple mechanisms(341).


Sources

(a) Potent anti-microbial activity of traditional Chinese medicine herbs against Candida species by Seneviratne CJ1, Wong RW, Samaranayake LP.(PubMed)
(b) Plant Products as Antimicrobial Agents by Marjorie Murphy Cowan(PMC)(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)(247) The role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging.by Moriguchi S1.(PubMed)
(310) Effect of hydrogen peroxide on antibacterial activities of Canadian honeysby Brudzynski K1.(PubMed)
(311) Streptomyces sp. JS520 produces exceptionally high quantities of undecylprodigiosin with antibacterial, antioxidative, and UV-protective propertiesby Stankovic N1, Radulovic V, Petkovic M, Vuckovic I, Jadranin M, Vasiljevic B, Nikodinovic-Runic J.(PubMed)
(312) Antimicrobial polyurethane thermosets based on undecylenic acid: synthesis and evaluation.by Lluch C1, Esteve-Zarzoso B, Bordons A, Lligadas G, Ronda JC, Galià M, Cádiz V.(PubMed)
(313) Allergic contact dermatitis from undecylenic acid in a commercial antifungal nail solution by Anguita JL1, Escutia B, Marí JI, Rodríguez M, De La Cuadra J, Aliaga A.(PubMed)
(314) Undecylenic acid and fungous infections by Landau JW.(PubMed)
(315) Undecylenic acid inhibits morphogenesis of Candida albicansby McLain N1, Ascanio R, Baker C, Strohaver RA, Dolan JW.(PubMed)
(316) [Inhibition of Candida mycelia growth by a medium chain fatty acids, capric acid in vitro and its therapeutic efficacy in murine oral candidiasis].[Article in Japanese]by Takahashi M1, Inoue S, Hayama K, Ninomiya K, Abe S.(PubMed)
(317) [Effects of inhibitory activity on mycelial growth of Candida albicans and therapy for murine oral candidiasis by the combined use of terpinen-4-ol and a middle-chain fatty acid, capric acid].[Article in Japanese]by Ninomiya K1, Hayama K, Ishijima S, Takahashi M, Kurihara J, Abe S.(PubMed)
(318) In vitro and in vivo immune stimulating effects of a new standardized Echinacea angustifolia root extract (Polinacea) by Morazzoni P1, Cristoni A, Di Pierro F, Avanzini C, Ravarino D, Stornello S, Zucca M, Musso T.(PubMed)
(319) Immune enhancing effects of Echinacea purpurea root extract by reducing regulatory T cell number and function by Kim HR, Oh SK, Lim W, Lee HK, Moon BI, Seoh JY.(PubMed)
(320) Applications of the phytomedicine Echinacea purpurea (Purple Coneflower) in infectious diseases. by Hudson JB1.(PubMed)
(321) Anethole, a potential antimicrobial synergist, converts a fungistatic dodecanol to a fungicidal agentby Fujita K1, Fujita T, Kubo I.(PubMed)
(322) Polygodial, an antifungal potentiator by Kubo I1, Taniguchi M.(PubMed)
(323) Enterococci from piglets--probiotic properties and responsiveness to natural antibacterial substances by Strompfová V1, Lauková A.(PubMed)
(324) Dietary supplementation with two Lamiaceae herbs-(oregano and sage) modulates innate immunity parameters in Lumbricus terrestris by Vattem DA1, Lester C, Deleon R, Jamison B, Maitin V.(PubMed)
(325) Oregano Oil for Candida(New health guide)(326) In vitro activity of origanum vulgare essential oil against candidaspecies by Cleff MB1, Meinerz AR, Xavier M, Schuch LF, Schuch LF, Araújo Meireles MC, Alves Rodrigues MR, de Mello JR.(PubMed)
(327) Augmented humoral immune response and decreased cell-mediated immunity by Aloe vera in rats. by Halder S1, Mehta AK, Mediratta PK.(PubMed)
(328) Antimicrobial activity of preparation Bioaron C by Gawron-Gzella A, Michalak A, Kędzia A.(PubMed)
(329) Antimicrobial activity of plant extracts on Candida albicans: an in vitro study by Doddanna SJ1, Patel S, Sundarrao MA, Veerabhadrappa RS.(PubMed)
(330) Antifungals: Aloe Vera(The candida diets)
(331) The Influence of Tea Tree Oil (Melaleuca alternifolia) on Fluconazole Activity against Fluconazole-Resistant Candida albicans Strains by Mertas A1, Garbusińska A1, Szliszka E1, Jureczko A1, Kowalska M1, Król W1.(PubMed)
(332) In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species by Mondello F1, De Bernardis F, Girolamo A, Cassone A, Salvatore G.(PubMed)
(333) [The effect of tannic acid on colonization of Candida in tissue conditioning material].
[Article in Japanese]by Kubota K.(PubMed)(334) [The effect of tannic acid on attachment of Candida albicans to plate denture lining material].
[Article in Japanese]by Tanaka T.(PubMed)
(335) Who Gets Yeast Infections?(Things for ladies)(336) Evaluation of Phytochemical Screening and Anti Inflammatory Activity of Leaves and Stem of Mikania scandens (L.) Wild by Banerjee S1, Chanda A1, Adhikari A2, Das A2, Biswas S3.(PubMed)
(337) The effect of oxalate on gluconeogenesis by isolated chicken hepatocytes. Increased sensitivity to inhibition as a result of biotindeficiency by Bannister DW, O'Neill IE.(PubMed)
(338) Growth of Candida albicans in a minimal synthetic medium without biotin. by Vidotto V1, Pugliese A, Gioannini P.(PubMed)
(339) Candida Infestation and BiotinWritten by Sean Brookwood Published on September 22, 2013
(340) Improved growth and viability of lactobacilli in the presence of Bacillus subtilis (natto), catalase, or subtilisin by Hosoi T1, Ametani A, Kiuchi K, Kaminogawa S.(PubMed)
(Oxidative stress responses in the human fungal pathogen, Candidaalbicans by Dantas Ada S1, Day A2, Ikeh M3, Kos I4, Achan B5, Quinn J6.(PubMed)
(341) Candida Diets: Part II: Hydrogen Peroxide Written by Jeff McCombs(342) Glutamine supplementation for young infants with severe gastrointestinal disease. by Brown JV1, Moe-Byrne T, McGuire W.(PubMed)

The Inter Relation of Free Radicals, Antioxidant Enzymes and Dementia (Lou Gehrig's Disease(Amyotrophic Lateral Sclerosis))

Kyle J. Norton (Scholar)


Dementia is a condition of neurodegeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgment. Over 47 millions of worldwide population are affected by the disease, mostly in the West.

The evaluation of the diseases by holistic medicine has been lacking, especially through conventional medicine research and studies.

Maintaining a balanced ratio of antioxidant and free radicals is essential for our body to perform a daily physiological function properly.

Truly, if our body is overwhelmed by overexpression of free radicals, it will be weakened by oxidative stress, causing adversely altered lipids, proteins, and DNA that can trigger a number of human diseases(a), including dementia.

* Free radicals are unstable molecules that contain at least an unpaired electron with function as oxidants or reductants by donated an electron to or accept an electron from other molecules to exhibit chain and domino's effects.

Most common oxygen-containing free radicals found epidemiologically in induced chronic diseases, including hydroxyl radical, superoxide anion radical, hydrogen peroxide, oxygen singlet, hypochlorite, nitric oxide radical, and peroxynitrite radical.

According to the University of Texas Medical Branch, observation of patients with amyotrophic lateral sclerosis (ALS) indicated that free radicals play a role in the expression of amyotrophic lateral sclerosis (ALS) through the alternation of \gene containing Cu,Zn superoxide dismutase (Cu,Zn-SOD).

Dr. Liu D said, "The selective degeneration of motor neurons in ALS may be caused by the high level of Cu,Zn-SOD present in and a large number of glutamatergic synapses projecting to these neurons"(b).

These selections of free radical in degeneration of motor neurons in ALS were attributed to free radical(mutation of Cu,Zn superoxide dismutase (Cu,Zn-SOD)) in long-term induction of oxidative stress, according to the study involved167 ALS patients (aged 59+/-13 years), treated or not with riluzole, compared with 62 age-matched healthy control subjects (aged 60+/-11 years) simultaneously, conducted by Hôpital de la Salpêtrière(c).

Some researchers suggested that cell damage and homeostatic disruption caused by free radicals can be inhibited by targeting free radicals of all kinds of molecules in the body(a), including lipids, nucleic acids, and proteins, through improving antioxidant status in the body.

* Antioxidants is a natural compound with function in inhibited molecules that cause oxidation before they can induce chains of domino's reaction.

* Antioxidants include those are produced by body tissue enzymes and externally dietary antioxidants intake from functional food sources.

Here is the summary of "The Battles of Free Radicals, Antioxidant Enzymes and Dementia (Lou Gehrig's Disease(Amyotrophic Lateral Sclerosis))"

Free radicals and Dementia (Lou Gehrig's disease)
Researchers found that glutamate in the synapses enhances the production of free radicals(77), due to its excitotoxicity, only in motor nerve cells but spares other nerve cells(74)(75) such as cells control senses and other body functions, causing disruption of astrocytes in regulated glutamate levels(76).

Antioxidants and Dementia (Lou Gehrig's disease)
1. Vitamin B12 (methylcobalamin)
High doses of vitamin B12 as an antioxidant have shown to improve or slow muscle wasting in the later stages of patients with ALS disease(78)(79).

2. Vitamin E
Vitamin E protected against cell membranes from lipid peroxidation damage(80) in reducing the risk of breakdown of the cell membrane cause of ALS(81).

3. Superoxide dismutase enzyme
Mutations in the superoxide dismutase enzyme can increase the risk ALS(82) in catalyzing the dismutation of superoxide into oxygen and hydrogen peroxide(83).

4. Cerebral cortex
Oxidative stress and DNA alternation triggered neurons damage(84) were found in elevated levels in mice with ALS(85).

5. Amino acids
Diet high in amino acids as antioxidants have shown some promising effect in treating ALS(86)(87).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca



Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
(a) Free radicals, antioxidants and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra(PMC)
(b) The roles of free radicals in amyotrophic lateral sclerosis by Liu D(PubMed)
(c) Blood oxidative stress in amyotrophic lateral sclerosis by Bonnefont-Rousselot D1, Lacomblez L, Jaudon M, Lepage S, Salachas F, Bensimon G, Bizard C, Doppler V, Delattre J, Meininger V(PubMed)
(74) System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice by Mesci P1, Zaïdi S1, Lobsiger CS1, Millecamps S1, Escartin C2, Seilhean D1, Sato H3, Mallat M1, Boillée S4.(PubMed)
(75) Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase by Lewis KE, Rasmussen AL, Bennett W, King A, West AK, Chung RS, Chuah MI1.(PubMed)
(76) Mutant disrupted-in-schizophrenia 1 in astrocytes: focus on glutamate metabolism by Abazyan S1, Yang EJ, Abazyan B, Xia M, Yang C, Rojas C, Slusher B, Sattler R, Pletnikov M.(PubMed)
(77) Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia by Globus MY1, Alonso O, Dietrich WD, Busto R, Ginsberg MD.(PubMed)
(78) Methyl Vitamin B12 but not methylfolate rescues a motor neuron-like cell line from homocysteine-mediated cell death. by Hemendinger RA1, Armstrong EJ 3rd, Brooks BR.(PubMed)
(79) [Clinical trials of ultra-high-dose methylcobalamin in ALS].[Article in Japanese] by Izumi Y1, Kaji R.(PubMed)
(80) Antioxidant effect of 4-nerolidylcatechol and α-tocopherol in erythrocyte ghost membranes and phospholipid bilayers. by Fernandes KS1, Silva AH, Mendanha SA, Rezende KR, Alonso A.(PubMed)
(81) Vitamin E serum levels and controlled supplementation and risk of amyotrophic lateral sclerosis by Michal Freedman D1, Kuncl RW, Weinstein SJ, Malila N, Virtamo J, Albanes D.(PubMed)
(82) Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes by Pratt AJ1, Shin DS1, Merz GE2, Rambo RP3, Lancaster WA4, Dyer KN3, Borbat PP5, Poole FL 2nd4, Adams MW4, Freed JH5, Crane BR2, Tainer JA6, Getzoff ED7.(PubMed)
(83) Hydrogen peroxide induce modifications of human extracellular superoxide dismutase that results in enzyme inhibition by Gottfredsen RH1, Larsen UG, Enghild JJ, Petersen SV.(PubMed)
(84) Oxidative DNA damage and alteration of glutamate transporter expressions in the hippocampal Ca1 area immediately after ischemic insult.by An SJ1, Kang TC, Park SK, Hwang IK, Cho SS, Chung MH, Won MH.(PubMed)
(85) Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis.by Matus S1, Lopez E, Valenzuela V, Nassif M, Hetz C.(PubMed)
(86) Amino acids as biomarkers in the SOD1(G93A) mouse model of ALS.by Bame M1, Grier RE, Needleman R, Brusilow WS.(PubMed)
(87) Branched-chain amino acids and amyotrophic lateral sclerosis: a treatment failure? The Italian ALS Study Group.[No authors listed](PubMed)

Monday 9 July 2018

The Whole Foods and Vegetables That Dissolve Chemical Carcinogens Before They Can Cause Cancers


By Kyle J. Norton, Scholar, Master of Nutrients

Cruciferous vegetables with rich of phytochemcals may be the potential foods that dissolve chemical carcinogens toxic effect before they can induce onset of cancers, some scientists suggested

Cancers are class of medical condition characterized by cells growth disorderly and uncontrollably in any tissue and organs in the body. In most cases, at the later stage, cancerous cells can travel a distance away to infectious other healthy cells and tissue.

Chemical carcinogens are types of chemical compounds that can cause cancer, mostly man-made.

According to the Universidade Federal de Ouro Preto, sulforaphane (SFN),the isothiocyanate (ITC) group of organosulfur compounds found in cruciferous vegetable expressed chemopreventive properties involved detoxification processes of chemical carcinogens.

Certain chemicals, such as benzene, beryllium, asbestos, vinyl chloride, and arsenic are known to induce human carcinogens.

This is tough to believe that exposure to chemical carcinogens in the outdoors, at home, and at work are associated to increase risk of getting cancer.

According to the Agency for Toxic Substances and Disease Registry, "More than 100,000 chemicals are used by Americans, and about 1,000 new chemicals are introduced each year" and "These chemicals are found in everyday items, such as foods, personal products, packaging, prescription drugs, and household and lawn care products"(4).

The agency also suggested that some chemical carcinogens can be harmful, not all contact with chemicals is dangerous to health(4).

Risk of developing cancer is depended totally  on how much, how long, how often, and when you are exposed to these chemicals.  

It is true, long term in contact with chemical carcinogens can lead to DNA alternation, the main cause of early onset of cancers(4).

Some researchers suggested that asbestos, nickel, cadmium, radon, vinyl chloride, benzidene, and benzene may act alone or with other carcinogens to increase the prevalent risk(4)

Occasional exposure to chemicals in adults  may be harmful to health, but to induce gene change is impossible.

However, when you are exposed is important because a small exposure in the womb, for example, may be more serious than a small exposure as an adult.

Dr. de Figueiredo SM, the lead author said, " In a dose dependent manner, ITC inhibits the viability of human cancer cells, modifies epigenetic events that occur in cancer cells and present antiinflammatory effect acting during the initial of uncontrolled cell proliferation." and "Chemical carcinogens are types of cancer caused by chemical toxins in induction of cellular and chromosomes change, DNA damage,... ".

The chemoprotective activity of the vegetable is the result of the significant expression of the antioxidants in exhibited cell cycle arrest and apoptosis in cancer cells as well as acting as the post-initiation stages of carcinogenesis, as a 'suppressing' agent involving the ability to modulate the Nrf2 in reduced damage from oxidative damage.

In fact, besides used as chemopreventive agent against chemical carcinogenesis, sulforaphane (SFN),the major chemical constituent of cruciferous vegetables also inhibited the drug-metabolizing enzymes that cause activation/neutralization of carcinogenic metabolites and protected normal healthy cells from environmental toxin induced of cancers.

Furthermore, the phytochemical exhibited the molecular mechanisms responsible for the overall chemopreventive effects on selective cytotoxicity, in reduced oxidate stress, free radicals produced by lipid peroxidation in cells.

In the study of tobacco smoke carcinogens induced chemical tumors, cruciferous vegetable consumption has shown to inversely associate the development of cancer.

In animal experiments. the chemopreventive effects of isothiocyanates, another compound found in cruciferous vegetable, inhibited the metabolic activation of carcinogens by cytochrome P450s, enzymes with function in metabolized potentially toxic compounds.

Taking together, intake of cruciferous vegetables have a potential health benefits against environment toxins in cancer development, but due to small size of the sample, further studies are necessary to address its viability.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca




Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Chemoprotection by sulforaphane: keep one eye beyond Keap1 by Myzak MC1, Dashwood RH.(PubMed)
(2) The antioxidant properties of organosulfur compounds (sulforaphane) by de Figueiredo SM1, Binda NS, Nogueira-Machado JA, Vieira-Filho SA, Caligiorne RB.(PubMed)
(3) Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane by Sharma R1, Sharma A, Chaudhary P, Sahu M, Jaiswal S, Awasthi S, Awasthi YC.(PubMed)
(4) Chemicals, Cancer, and You by Agency for Toxic Substances and Disease Registry

****** Cayenne, A Spice That Blocks Airway Inflammation, Scientists Reveal

Kyle J. Norton, Master of Nutrition

Scientists in numbers of institute suggested that cayenne, a kitchen spice may process a significant effect in inhibited airway inflammation, an important component of asthma, chronic obstructive pulmonary disease (COPD), and the various cough syndromes.

Conventional medicine has synthesized the effect of many of herbal plants' secondary metabolites, since the discovery of penicillin, the first antibiotic extracted from a very primitive plant, the fungus Penicillium, in 1928, used for treatment of infection.

In years, herbalist are suspicious that these plants must contain some substances used together for healing purposes, without knowing the existence of each single ingredient.

Today, under microscopes of new technology, scientists discovered that effectiveness of herbal plants in treatment of conditions and diseases are attributed to their's secondary metabolites.

Secondary metabolites are organic compounds, according to Massachusetts Institute of Technology that serve(7)
* As competitive weapons used against other bacteria, fungi, amoebae, plants, insects, and large animals.

* As metal transporting agents.

* As agents of symbiosis between microbes and plants, nematodes, insects, and higher animals.

* As sexual hormones; and 

* As differentiation effectors.

for survival of the plants producing them, 


Following the herbalist food step and used herbal medicine as a fundamental source, conventional medicine has discovered numbers of single ingredient medication, including quinine (from cinchona bark), and morphine (from the opium poppy)......

According to the Dr. Stanley F. Malamed, the lead author in the study of  causative factors for acute asthma suggestion, "(In acute airway inflammation) Inflammation may occur as a result of either immunologic or nonimmunologic airway insults, which produce airway edema and cause the immigration of inflammatory cells into the lumen through the epithelium "(5)

Chronic airway inflammation can lead to chronic obstructive pulmonary disease (COPD), a progressive syndrome caused by expiratory airflow limitation as a result of airway remodeling, including an increase in airway smooth muscle (hyperplasia and hypertrophy),......

More importantly, the longer duration of air way inflammation may lower the lung function in induction of the worse of the bronchial hyperresponsiveness and symptoms(6)

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belongings to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.

The herb or food has been used in traditional medicine to increase metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises and neuralgia, ......., particularly, in treatment of inflammation caused by invasion of microbial organisms and allergens.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases, including inflammation.

Red pepper (Capsicum baccatum) extracts, according to the study by the Federal University of Rio Grande do Sul (UFRGS), exerted its anti-inflammatory properties through in inhibiting the neutrophil migration induced by carrageenan (Cg).

In animal study, the ethanolic and butanol extracts (200mg/kg, p.o.) presented a significant anti-inflammatory activity through their antioxidant phenolic and flavonoid compounds against oxidative and inflammation-related pathological processes, including arway inflammation.

β-Defensin, members of the antimicrobial peptide found in cayenne inhibited the expression of the mRNA of anti-inflammatory cytokine during bacterial invasion, through stimulating immunomodulatory effects.

Other research suggested that anti-inflammatory effect induced by red pepper may be by inhibition of pro-inflammatory cytokine production at the inflammatory sites, such as upper airway.

Regular intake of Cayenne pepper can improve immune system against microbial infection and reduced risk of airway inflammation but overdose is found to induce toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca



Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Red Pepper (Capsicum baccatum) Extracts Present Anti-Inflammatory Effects In Vivo and Inhibit the Production of TNF-α and NO In Vitro by Allemand A1,2, Leonardi BF1, Zimmer AR1, Moreno S3, Romão PR2, Gosmann G1.(PubMed)
(2) Anti-inflammatory effects of red pepper (Capsicum baccatum) on carrageenan- and antigen-induced inflammation by Spiller F1, Alves MK, Vieira SM, Carvalho TA, Leite CE, Lunardelli A, Poloni JA, Cunha FQ, de Oliveira JR.(PubMed)
(3) Antioxidant and anti-inflammatory properties of Capsicum baccatum: from traditional use to scientific approach by Zimmer AR1, Leonardi B, Miron D, Schapoval E, Oliveira JR, Gosmann G.(PubMed)
(4) Defensin γ-thionin from Capsicum chinense has immunomodulatory effects on bovine mammary epithelial cells during Staphylococcus aureus internalization by Díaz-Murillo V1, Medina-Estrada I1, López-Meza JE1, Ochoa-Zarzosa A2.(PubMed)
(5) Learn more about Airway Inflammation(Science Direct)
(6) Why Does Airway Inflammation Persist? Is It Failure to Treat Early? by SØREN PEDERSEN(ATS Journals)
(7) The natural functions of secondary metabolites by Demain AL1, Fang A(PubMed)


Sunday 8 July 2018

Asparagus, the Veggie with Anti Oral Cancer Cells Properties


Kyle J. Norton, Master of Nutrition

Whole food(herbal medicine) used as medical treatment, linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.

But many researchers have raised question of herbal quality, because geographic differences, time of grown and harvest, etc. may effect their's potency.

Oral cancer is a medical condition characterized by irregular cells growth in the oral cavity. In the early stage, the abnormal cells only appear in the surface lining of the cavity. However, in the late stage, the infectious cells may travel a distance away from the original site to invade other cells and tissue.

Early diagnosed oral cancer may have a close to 100% recovery(3).

According to the cancer society, the 5 survival rate of oral cancer is about 60% plus without taking into consideration of the stage of cancer.

According to the Oral Cancer Foundation in the article of "Oral Cancer Fact", in US, approximately,  50000 Americans will be diagnosed with oral pharyngeal cancer this year. It will cause about 10,000 deaths.

The early symptoms of oral cancer include lip or mouth sores and persistent pain,.... Check with dentist, if you experience the above unexplained or persistent symptoms, particularly, if sore mouth does not heal in 2 weeks.

Although, the causes of oral cancers are still debatable, some researchers suggested that age, smoking, alcohol,  gender, diet,....... HPV and sun exposure are considered as  prevalent risk factors in contribution to the early onset of the cancer(3).

Dr.Payal Garg and Freny Karjodkar in the study of " “Catch Them before it Becomes Too Late”—Oral Cancer Detection. Report of Two Cases and Review of Diagnostic AIDS in Cancer Detection", said, "(Dentists and Doctors should the region with appearance of ) A red or white patch or a change in color, texture, size, contour, mobility, or function of intraoral, perioral, or extraoral tissue should arouse suspicion of the presence of malignant or premalignant lesions in these regions"

Regular intake of Asparagus may have a reduced risk and development of oral cancer, some scientists suggested.

Asparagus is a flowering plant belongings to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa and western Asia.

The veggie has been used in early times as a vegetable and medicine, because of its delicate flavour and diuretic properties.

Treatment of oral cancer in conventional medicine involved immune suppressors such as chemo drugs may contribute to complications of patients with oral cancer, such as infection.

According to University of Florida, asparagus use currently in cancer prevention rather than treatment.of oral cancer probably due to mechanism of action for bioactive compounds, such as epigallocatechin, epicatechin-3-gallate,....

Dr. the lead author said, " Preclinical and clinical evidence for the use of green tea, raspberry, asparagus, and cannabis extracts,...... diet changes, supplementation with antioxidants, high-dose vitamin C therapy, and cannabinoid use have been suggested to decrease cancer cell replication and increase chance of remission"

In the study of blood sample of 40 oral cancer patients undergoing treatment in the radiotherapy unit of Regional Cancer Institute, researchers found that arsparagus racemosus Willd. exerted a strong effect against infection caused by Staphylococcus aureus (23.2%), Escherichia coli (15.62%), Staphylococcus epidermidis (12.5%), Pseudomonas aeruginosa (9.37%), Klebsiella pneumonia (7.81%), Proteus mirabilis (3.6%), Proteus vulgaris (4.2%) and the fungal pathogens Candida albicans (14.6%), Aspergillus fumigatus (9.37%).

Researchers at the institute also suggested, oral cancer patients were neutropenic with abnormally low level of neutrophils and and prone to secondary micro infection.. Asparagus may be used as antimicrobial agent to check the secondary infections in cancer patients.

Taking altogether, asparagus has shown to exert a significant anti progression, complications and treatment of oral cancer, but further multi centers and large sample size studies are necessary to validate this claim.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Review of Various Herbal Supplements as Complementary Treatments for Oral Cancer by Godsey J1, Grundmann O1.(PubMed)
(2) In vitro antimicrobial activity of ten medicinal plants against clinical isolates of oral cancer cases by Panghal M1, Kaushal V, Yadav JP.(PubMed)

Saturday 7 July 2018

The Best Detoxification Diet, That Works, Scientists Suggest

American diet contains high saturated, trans fat, and other harmful substances such as sugar, caffeine, pesticides, additive substances, and less in fruits and vegetables.

These types of harmful substances are toxic.

Some researchers suggested that diet and exposure to environmental toxins can damage function of the mitochondria in cells in converting food to energy, affecting the organs function in protection of the body in all aspects.

The damage to mitochondria can increase over expression of free-radicals in induction of cytotoxicity to cells and tissue though a negative chain reaction
Foods that can detoxify our body against cytotoxicity include
1. Spinach
Spinach contains 
* High levels of vitamin A, E, C , the free radical scavengers with function in reduced oxidative stress by improving production of  antioxidant enzymes(1)(2).

* Numbers of trace minerals act as antioxidant in inhibited ROS species such as iron, potassium, magnesium, zinc and calcium(2). The presences of trace minerals in equate amount  are vital for a healthy heart. 

* Antioxidants,  such as lutein and beta carotene(3) strengthen our immune system and fight against the forming of free radicals. 

People with kidney disease should not eat spinach, because it is rich with oxalates.

Without drinking a lot of water or juice, intake of the veggie will increase risk of kidney stones formation.

2. Broccoli
Broccoli is high in vitamin C(1), an antioxidant that has a property in reduced the risk of inflammation and prevented forming of free radicals caused by toxins in our body. 

Study shows that some of the chemicals such as indole 3, selenium and diindolymethane have anti cancer properties and help to prevent and repair DNA damaging cells(4)(9).

3. Garlic
Garlic is a super natural food. Besides having proven record in preventing heart diseases, lower cholesterol level, elevate blood pressure(5),  it also contains high amounts of allicin, an antibody that helps to reduce inflammation and fight off degeneration caused by virus, bacteria, strengthening our immune system(6) and forming of free radicals(7).

The sulfur element helps to rejuvenate our body by increasing the function of liver in removing toxins(7).

4. Black berry
Besides vitamins C and E(1) blackberry contains anthocyanins and ellagic acid that work together in preventing inflammation, improving mental performance as well as strengthening the immune system(8). Its antioxidant function also remove accumulation of heavy metal toxins in our body(9).

5. Mellon
Mellon contains high amounts of antioxidant enzyme(9), minerals(2) and the powerful antioxidant chlorophyll(9), which is rich in antioxidants, vital minerals such as magnesium, iron, potassium, calcium, and essential fatty acids(2) with functions in removed heavy metals accumulated in the brain and toxins in our kidney(10)

6. Green tea
Green tea  balances the PH level(11) in the blood, it also contains polyphenolic catechins, a powerful antioxidant that strengthens the immune system(9), fights against free radicals building up and detoxes our body though urinary secretion(9)(12).

7.  Cooked Tomato
Tomatoes contain high amounts of alpha and beta carotene that help to strengthen the body's immune system fight off inflammation from bacteria and virus causing many types of chronic diseases(3). 

The vegetable also contains lycopene(13), a powerful antioxidant that prevents the forming of free radicals caused by accumulation of toxic substances in the body when work together with lutein(3). Be sure that the veggie is well cooked(14).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats by Michael J. Ryan,1 Holly J. Dudash,1 Megan Docherty,1 Kenneth B. Geronilla,1,2 Brent A. Baker,2G. Gregory Haff,1 Robert G. Cutlip,2 and Stephen E. Alway(PubMed)
(2) Vitamins and minerals functioning as antioxidants with supplementation considerations Lee R. McDowell1 , Nancy Wilkinson, Rachel Madison and Tara Felix Department of Animal Sciences University of Florida
(3) Potential Role of Carotenoids as Antioxidants in Human Health and Disease by Joanna Fiedor* and Květoslava Burda(PubMed)
(4) Nutritional Epigenetic Regulators in the Field of Cancer by Michael Schnekenburger1, Marc Diederich2, in Epigenetic Cancer Therapy, 2015
(5) Garlic and Cardiovascular Disease: A Critical Review 
Khalid Rahman Gordon M. Lowe, The Journal of Nutrition, Volume 136, Issue 3, 1 March 2006, Pages 736S–740S,https://doi.org/10.1093/jn/136.3.736S
(6) The Immunomodulation and Anti-Inflammatory Effects of Garlic Organosulfur Compounds in Cancer Chemoprevention by Georgia Schäfer1 and Catherine H. Kaschula(PubMed)
(7) The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins by Rabinkov A1, Miron T, Konstantinovski L, Wilchek M, Mirelman D, Weiner L(PubMed)
(8) Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days by Stoner GD1, Sardo C, Apseloff G, Mullet D, Wargo W, Pound V, Singh A, Sanders J, Aziz R, Casto B, Sun X(PubMed)
(9) Free radicals, antioxidants and functional foods: Impact on human health byV. Lobo, A. Patil, A. Phatak, and N. Chandra(PubMed)
(10) Toxicity, mechanism and health effects of some heavy metals by Monisha Jaishankar, Tenzin Tseten, Naresh Anbalagan, Blessy B. Mathew, and Krishnamurthy N. Beeregowda(PubMed)
(11) Evaluation of the pH and titratable acidity of teas commercially available in Brazilian market ORIGINAL | ORIGINAL Avaliação do pH e titrabilidade ácida de chás comercialmente disponíveis no mercado brasileiro 
(12) 5 Kidney Cleansing Drinksby Dr. Group by Dr. Edward Group DC, NP, DACBN, DCBCN, DABFM
(13) Lycopene as A Carotenoid Provides Radioprotectant and Antioxidant Effects by Quenching Radiation-Induced Free Radical Singlet Oxygen: An Overview by Jalil Pirayesh Islamian, Ph.D.* and Habib Mehrali, M.Sc(PubMed)
(14) Cooking Tomatoes Boosts Disease-Fighting Power, Date:April 23, 2002 (by Cornell University)