Saturday 2 August 2014

Obesity Complication of Artheroclerosis

By Kyle J. Norton

Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.


How to calculate your BMI index
BMI= weight (kg)/ height (m2)


 Artheroclerosis, also known as
arteriosclerotic vascular disease is defined as a condition of thickening of the arterial wall as a result of plague accumulation due to building up of fat and cholesterol.

How Obesity associates with Artheroclerosis
1. In a study of "
[Left ventricular hypertrophy and thickening of common carotid artery wall in men aged 40 - 54 years with I degree arterial hypertension]." [Article in Russian] by Grigoricheva EA, Sorokin AV, Korovina OV, Pestova DL., posted in PubMed, researchers found that Formation of left ventricular hypertrophy was related to parameters of 24 hour blood pressure monitoring, arterial hypertension in brothers and sisters, body weight, and duration of obesity. Significant medium power relation was obtained between tension of endothelial system of hemostasis (protein C) and severity of left ventricular hypertrophy (correlation coefficient - 0,3). Age, heredity, low density lipoprotein, cholesterol, uric acid level mattered for IMT increase.

2. According to the study of "High rate of increased carotid intima-media thickness and atherosclerotic plaques in Chinese asymptomatic subjects with central obesity" by Ko GT, Chow CC, Leung G, Au-Yeung TW, Chan WB, Lam CS, Lo M, Lee KK., posted in PubMed, researchers concluded that among Hong Kong Chinese asymptomatic subjects with central obesity, there was a high rate of CVD risk factors. We found that 19% of these subjects had carotid atherosclerotic plaques and 10% of them had abnormal IMT (>0.9 mm). Carotid IMT study may serve as an appropriate screening tool to diagnose atherosclerosis in the centrally obese middle-aged population.

3. In the study of "Obesity, atherosclerosis and the vascular endothelium: mechanisms of reduced nitric oxide bioavailability in obese humans" by
I L Williams, S B Wheatcroft, A M Shah and M T Kearney, posted in International Journals of Obesity, researchers wrote in abstract that it is now well established that obesity is an independent risk factor for the development of coronary artery atherosclerosis. The maintenance of vascular homeostasis is critically dependent on the continued integrity of vascular endothelial cell function. A key early event in the development of atherosclerosis is thought to be endothelial cell dysfunction.

4. According to the study of "Body mass index classification misses subjects with increased cardiometabolic risk factors related to elevated adiposit" by J Gómez-Ambrosi, C Silva, J C Galofré, J Escalada, S Santos, D Millán, N Vila, P Ibañez, M J Gil, V Valentí, F Rotellar, B Ramírez, J Salvador and G Frühbeck, posted in International Journals of Obesity, researchers concluded that Given the elevated concentrations of cardiometabolic risk factors reported herein in non-obese individuals according to BMI but obese based on body fat, the inclusion of body composition measurements together with morbidity evaluation in the routine medical practice both for the diagnosis and the decision-making for instauration of the most appropriate treatment of obesity is desirable.

5. Etc.

 Treatments of Obesity and Artheroclerosis
1. According to the study of "Acute effects of epigallocatechin gallate from green tea on oxidation and tissue incorporation of dietary lipids in mice fed a high-fat diet" by M Friedrich, K J Petzke, D Raederstorff, S Wolfram and S Klaus, posted in International Journals of Obesity, researchers found that Anti-obesity effects of EGCG can be explained by a decreased food digestibility affecting substrate metabolism of intestinal mucosa and liver, leading to increased post-prandial fat oxidation and reduced incorporation of dietary lipids into tissues.

2. in P54 of Poster session III: Physical activity, exercise, nutrition and body composition, "The Effect of Long-term Taijiquan Practice on the Lipid Metabolism and Hormone Levels among Obese University Students" by HaiJun Zhang1, HaiLi Zhang and XiaoTao Guo. posted in International Journals of Obesity, researchers concluded that Long-term Taijiquan practice improves the components of blood-lipid, promotes the fat catabolism, adjusts the endocrine, and is helpful for health, fitness and losing weight.

3. In P63 of Poster session III: Physical activity, exercise, nutrition and body composition, "Effect of the Diabolo Exercise on Aged Women" by Xinbao Wang1 and Dawu Huang, posted in International Journals of Obesity, researchers found that Diabolo exercise has a good effect on reducing obesity and improving the function of the cardiovascular system for aged women.

4. Etc.

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Egg and scallion fried rice

Recipe attributed to 125 best  Chinese recipes by Bill Jones and Stephen Wong, published by Robert Rose

1 tbsp. vegetable oil  15 mL
1 egg, beaten  1
salt and pepper to taste
1 tbsp. minced ginger root  15mL
2 green onions, finely chopped   2
2tbsp. chicken stock   25mL
2 tbsp. red bell pepper, finely chopped  25mL
3 cups cooked rice  750mL
salt and pepper to taste
1. in a non stick wok or large skillet, heat 1/2 tbsp. (7mL) oil over medium heat. Add eggs and cook to make a thin omelet by swirling the pan so the eggs flow onto as large as possible. Season lightly with salt and pepper. Remove, chopped coarsely and set aside.
2. heat remaining oil in wok over medium heat. Add ginger root and onions; stir-fry until fragrant, about 30 seconds. Add stock and red pepper; stir briefly. Add rice; stir-fry until well mixed and the grains are separated, about 2 minutes. Ass omelet pieces and stir to mix well. Season with salt and pepper; stir to mix. Serve immediately. Serving 4. 
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The Few Minutes Recipe: Hummus

Recipe attributed to 30 minutes vegetarian recipes by Marie-laude Morin, Publisher Robert Rose at www,robertrose.ca

Using canned chickpeas means you can prepare this hummus in just a few Minutes with no cooking required. Serve with toasted pita chips.
Tips: this recipe can be lighter by replacing 1 tbsp. (15mL) olive oil with the same amount of water. It's just as tasty. For presentation, drizzle a little olive oil on top  and sprinkle with fresh parsley.
Food processor
11/2 cup drained rinsed canned chickpeas  (375mL)
1 clove garlic, coarsely chopped  1
3 tbsp. freshly squeezed lemon juice  (45mL)
1 tbsp. olive oil  (15mL)
1 tbsp. tahini  (15mL)
1/2 tsp. salt  (2mL)
Freshly ground pepper
In a food processor, puree chickpeas, garlic, lemon juice, olive oil, 3 tbsp. (45mL) water, tahini and pepper to taste, until smooth and creamy.
Variation: Fresh herb hummus: Add 2 tbsp. (30mL) fresh Italian flat-leaf parsley leaves, 6 fresh basil leaves and 2 tsp. (10mL) thyme leaves with chickpeas. Make 12.

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Friday 1 August 2014

Herbal Chickweed and Antimicrobial effects

Chickweed is a cool-season annual plant often eaten by chickens., genus S. media, belonging to the family Caryophyllaceae, native to Europe. The herb has been used in herbal medicine to treat skin conditions, indigestion, eczema, cough, rashes, etc. and as astringent, carminative, demulcent, diuretic, expectorant, laxative, refrigerant, vulnerary agent.

Chemical constituents(a)(b)
1. Igenin 6-C-beta-D-galactopyranosyl-8-C-alpha-L-arabinopyranoside
2. Apigenin 6-C-alpha-L-arabinopyranosyl-8-C-beta-D-galactopyranoside
3. Apigenin 6-C-beta-D-galactopyranosyl-8-C-beta-L-arabinopyranoside
4. Apigenin 6-C-beta-D-glucopyranosyl-8-C-beta-D-galactopyranoside
5. Apigenin 6, 8-di-C-alpha-L-arabinopyranoside
6. Alkaloidal glycoside
7. Glucodichotomine B
8. Neolignan glycosides
9. Dichotomosides A, B, C, and D
10. Phenylpropanoid glycoside
11. Dichotomoside E
12. Saponins
13. Mucilage
14. PABA
15. Coumarin,
16. Flavonoids (rutin)
17. Hydroxycoumarin

HSV-2 is a members of the herpesvirus family and can be spread through contact with saliva,
 Stellarmedin A, a novel antiviral protein purified from Stellaria media, showed to inhibit the an proliferative and peroxidase activities of HSV-2 protein, according to the study by the Jiangsu Province and Chinese Academy of Sciences(1). Homologous defensins, Sm-AMP-D1 and Sm-AMP-D2, were isolated from seeds of common chickweed Stellaria media L, according to Russian Academy of Sciences, showed a strong  inhibitory activity against phytopathogenic fungi and oomycetes and may be a potent promising for engineering pathogen resistance in crops(2). α-hairpinin, a novel antifungal peptide isolated from Stellaria media seeds, also exhibited high broad-spectrum activity against fungal phytopathogens(3).

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References
(a) [Studies on chemical constituents from stellaria media. I].[Article in Chinese] by Dong Q1, Huang Y, Qiao SY.(PubMed)
(b) Bioactive constituents from Chinese natural medicines. XIV. New glycosides of beta-carboline-type alkaloid, neolignan, and phenylpropanoid from Stellaria dichotoma L. var. lanceolata and their antiallergic activities by Morikawa T1, Sun B, Matsuda H, Wu LJ, Harima S, Yoshikawa M.(PubMed)
(1) Purification and characterization of a novel anti-HSV-2 protein with antiproliferative and peroxidase activities from Stellaria media by Shan Y1, Zheng Y, Guan F, Zhou J, Zhao H, Xia B, Feng X.(PubMed)
(2) Isolation, molecular cloning and antimicrobial activity of novel defensins from common chickweed (Stellaria media L.) seeds by Slavokhotova AA1, Odintsova TI, Rogozhin EA, Musolyamov AK, Andreev YA, Grishin EV, Egorov TA.(PubMed)
(3) Novel antifungal α-hairpinin peptide from Stellaria media seeds: structure, biosynthesis, gene structure and evolution by Slavokhotova AA1, Rogozhin EA, Musolyamov AK, Andreev YA, Oparin PB, Berkut AA, Vassilevski AA, Egorov TA, Grishin EV, Odintsova TI.(PubMed)

Obesity Complication of Peripheral Vascular Disease

By Kyle J. Norton

Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

 How to calculate your BMI index
BMI= weight (kg)/ height (m2)

 Peripheral Vascular Disease is defined as a condition of obstruction of arteries as a result of hardening and narrowing of the arteries which supply blood to the lower extremity.

 How Obesity associates with Peripheral Vascular Disease
According to the study of "Abdominal obesity and peripheral vascular disease in men and women: a comparison of waist-to-thigh ratio and waist circumference as measures of abdominal obesity" by Lu B, Zhou J, Waring ME, Parker DR, Eaton CB., posted in PubMed, researchers indicated in abstract that WTR is associated with PVD in men and women. In contrast, WC is associated with PVD in women, but not in men. Well-controlled prospective studies are needed to assess these two measures of body fat distribution and its association with the development of PVD in men and women.

2.In a study of "The risk of general and abdominal adiposity in the occurrence of new vascular events and mortality in patients with various manifestations of vascular disease" by Kanhai DA, Kappelle LJ, van der Graaf Y, Uiterwaal CS, Visseren FL., posted in PubMed, researchers found that :General adiposity is associated with an increased risk for vascular mortality in CAD patients and a decreased risk for (vascular) mortality in PAD patients.International Journal of Obesity.

3. In the study of "
Patients with coronary, cerebrovascular or peripheral arterial obstructive disease differ in risk for new vascular events and mortality: the SMART study" by Achterberg S, Cramer MJ, Kappelle LJ, de Borst GJ, Visseren FL, van der Graaf Y, Algra A; SMART study Group., posted in PubMed, researchers found that Patients with a recent CVD or PAOD have almost twice the risk for future vascular events than those with CAD.

4. According to the study of "Peripheral vascular disease and peripheral neuropathy in individuals with cardiometabolic clustering and obesity: National Health and Nutrition Examination Survey 2001-2004" by Ylitalo KR, Sowers M, Heeringa S., posted in PubMed, researchers suggested that Obesity and clustering markedly increased the likelihood of LEDs in this sample and identified a group for whom preventive activities may reduce the risk of future disability.

5. In the abstract of "Obesity and fat distribution as predictors of aortoiliac peripheral arterial disease in middle-aged men" by Jakovljević B, Stojanov V, Lović D, Paunović K, Radosavljević V, Tutić I., posted in PubMed, researchers found that This study has identified the quantity of fat tissue (body fat over 26.5%) and its visceral distribution (waist-hip ratio over 1.02) as predictors of aortoiliac PAD in middle-aged men. Body mass index, a crude indicator of obesity, should be combined with these parameters when assessing the risk for aortoiliac PAD.

6. in the study of "Relationship of obesity distribution and peripheral arterial occlusive disease in elderly men" by Planas A, Clará A, Pou JM, Vidal-Barraquer F, Gasol A, de Moner A, Contreras C, Marrugat J., posted in PubMed, the study indicated that Abdominal fat distribution, but not total body fatness, is associated with peripheral arterial occlusive disease, independently of concurrent cardiovascular risk factors.

7. Etc.


Treatments of Obesity and Peripheral Vascular Disease
1. In abstract of the study of "
The prognostic impact of general and abdominal obesity in peripheral arterial disease" by Giugliano G, Brevetti G, Laurenzano E, Brevetti L, Luciano R, Chiariello M., posted in PubMed, researchers concluded that Abdominal obesity and, to a lesser degree, general obesity worsen the prognosis of PAD patients independently of possible confounding factors. Weight reduction should be integrated in the active management of these patients.

2. According to the abstract of "The management of combined coronary artery disease and peripheral vascular disease" by Cassar A, Poldermans D, Rihal CS, Gersh BJ., posted in PubMed, researchers wrote that Coronary artery disease (CAD) and peripheral vascular disease (PVD) remain highly prevalent in the population due to population ageing, smoking, diabetes, unhealthy lifestyles, and the epidemic of obesity, and frequently coexist. The management of combined CAD and PVD is a common challenge and brings with it numerous clinical dilemmas. The goal of this article is to review the prevalence of PVD and its major impact upon prognosis in patients with known CAD and in turn to review the impact of CAD upon the prognosis of patients with PVD. This review will also highlight issues related to the peri-operative evaluation and management of patients going to vascular surgery, including medical optimization as well as the performance and timing of coronary revascularization.

3. In the study of "Angio-Seal use in patients with peripheral arterial disease (ASPIRE)" by Katzenschlager R, Tischler R, Kalchhauser G, Panny M, Hirschl M., posted in PubMed, researchers wrote that Complications (2 minor bleedings, 1 pseudoaneurysm) were not associated with high risk groups (these were: 69 antegrade punctures, 22 obese and 32 hypertensive patients). Three-month postinterventional diameter and blood velocity changes were <1%., and concluded that patients with peripheral arterial disease in the region of the puncture site and patients at higher complication risk can safely and effectively be closed with an Angio-Seal device. At the puncture site, no lumen change can be observed 3 months postinterventional.

4. Etc.
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Easy and Quick Vegan Recipe: Toast pita chips

Recipe attributed to 30 minutes vegetarian recipes by Marie-laude Morin, Publisher Robert Rose at www,robertrose.ca

This recipe can be served anywhere and anytime. The toasted iota points are a marvelous accompanied to hummus, guacamoles and dips.
Preheat over 400 degree F (200 degree C)
Baking sheet, lined with parchment paper.
4 pitas
Olive oil
Ground cumin
Paprika
1. Cut pitas into points. Place on prepared baking sheet. Brush with olive oil. Sprinkle with cumin and paprika to taste.
2. Bake in preheated oven for about 10 minutes or until bread is crispy. Let cool on pan on a wire rack. Serve 4.
Variation: Replace cumin and paprika with smoke paprika or your favorite dried herb for a different flavor.
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Vegan recipes: Cilantro Salsa

Recipe attributed to 30 minutes vegetarian recipes by Marie-laude Morin, Publisher Robert Rose at www,robertrose.ca

Thus recipe can easily to double, triple or even quadrupled to suit the number of your guests. You will soon see bottom of the bowl.
Tips: Cilantro is a magic ingredient in this recipe so don't be tempted to leave it out or substitute another herb. The salsa can be made up to 4 hours ahead of serving. Cover and let stand at room temperature -- do not refrigerate it or the tomato will lose its flavor.
1 tomato, diced   1
1/4 cup diced red onion   60mL
1/4 cup chopped fresh cilantro  60mL
1/4 cup tomato juice  60mL
1  chile pepper, chopped   1
Salt and fresh ground black pepper
In a bowl, combine tomato, red onion, cilantro, tomato juice and chile pepper. Season with salt to taste. Make about 1/12 cup (375mL)
Variation: Cilantro avocado salsa: Add I dice of avocado with the tomato.
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