Tualang Honey Which Kills Leukemia Cancer Cells In Vivo and Vitro, Scientists Say

By Kyle J. Norton


Leukemia is a chronic and medical condition of body's blood-forming tissues including the bone marrow characterized by high numbers of abnormal white blood cells.

Most cases of leukemia start on the cells in the tissues the of bone marrow. 

Bone marrow is a semi-solid tissue found within the spongy or cancellous portions of the bones.

In the stage system, patients with leukemia are classified into 5 different stages depending on the levels of abnormal white blood cell. treatment of leukemia is also depended on the size of the tumor and grade of metastasis.

According to the statistic, in the US, approximately 170,000 people will be diagnosed with a form of blood cancer in 2018. In other words, every 3 minutes, a person in the US is diagnosed with blood cancer.

The 5 years of the survival rate of the patient with leukemia are totally depending on the types.
Patients diagnosed with chronic myeloid (or myelogenous) leukemia (CML), chronic lymphocytic leukemia (CLL), acute myeloid (or myelogenous) leukemia (AML) and acute lymphocytic (or lymphoblastic) leukemia (ALL) have the 5 years survival rate of 68%, 86%, 274.% and 715 respectively.

However, in children diagnosed with acute lymphocytic (or lymphoblastic) leukemia (ALL), the 5 years survival rate is significantly higher. Children and adolescents between 5 - 15 years of age, and younger than 5 years of age have a rate of  91.8% and 94%, respectively.

Researchers do not know the exact causes of leukemia. 

Certain risk factors such as long-term exposure to radioactive such as radio and chemotherapy and smoking, inhaling Benzene and Formaldehyde, and the genetic preposition is associated with the increased risk of cancer.

D,. Fircanis S, the lead scientist in the cancer tram at The Miriam Hospital in the examining the risk of leukemia in long-term smokers said, "current and ever smokers have 40% (RR 1.40, 95% CI 1.22-1.60; P < 0.001) and 25% (RR 1.25, 95% CI 1.15-1.36; P < 0.001) increased risk of developing AML when compared with non-smokers" and "Intensity of smoking of <10, 10-20, 20-30, and >30 cigarettes per day was associated with RRs of AML of 1.27, 1.36, 1.55, and 1.77, respectively (P < 0.001 for trend). Duration of smoking of <20 and >20 years was associated with RRs of 1.07 and 1.44, respectively (P < 0.001 for trend)".

These results clearly suggested that the risk of leukemia is increased substantially and linearly to the years of smoking and numbers of cigarettes smoked daily

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

With an aim to find the natural whole food for the treatment of leukemia, scientists at the joint study led by the Mashhad University of Medical Sciences investigate the effects of the dietary combination of honey and Ardeh on chemotherapy-induced complications in patients with acute myeloid leukemia (AML).

The double-blind randomized placebo-controlled clinical-trial included a total of 107 AML patients who underwent chemotherapy for at least 30 consecutive days in Imam Reza and Ghaem teaching hospitals (Mashhad, Iran). 

The treatment group was given a combination of 50 grams of honey and 150 grams of Ardehwas added to the treated group's diet for 30consecutive days, three times each day; while the untreated group was received their regular diet.

After one month, both groups were all examined and lab tests were taken by an internist and laboratory technicians.

The treatment group showed a reduction of symptoms of fever compared to untreated group.

Patients who were given the special honey and Ardeh compound also showed significantly less gastrointestinal complications, compared to the untreated group with no side effects.

Further analysis of the treatment group, researchers said, "(honey and Ardeh compound) ameliorate gastrointestinal complications and reduce fever and neutropenia in AML patients

These results indicated that Honey and Ardeh, the easily accessible materials can be used to attenuate symptoms caused by chemotherapy in AML patients.

Additionally, in the joint study led by the Universiti Sains Malaysia to evaluate the antileukemic effect of Tualang Honey on acute and chronic leukemia cell lines, researchers showed that leukemia cell lines (K562 and MV4-11) and human mononuclear cell incubated with increasing concentrations of Tualang Honey display the presence of cell depredation followed by apoptotic bodies.

More precisely, application of Tualang honey induced 53.9% and 50.6% apoptosis on K562 and MV4-11, respectively, and 37.4% on the human mononuclear cell.

Taken altogether, Tualang honey used alone, and common honey combined with Ardeh may be used for the prevention and adjunct therapies combined with the primary medicine for the treatment of leukemia

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Effects of Dietary Honey andArdeh Combination on Chemotherapy- Induced Gastrointestinal and Infectious Complications in Patients with Acute Myeloid Leukemia: A Double-Blind Randomized Clinical Trial by Ebrahimi M1, Allahyari A2, Ebrahimi M3, Hesam H4, Hosseini G4, Karimi M5, Rezaiean A5, Kazemi MR5. (PubMed)
(2) Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines by Nik Man NM1, Hassan R1, Ang CY1, Abdullah AD2, Mohd Radzi MA1, Sulaiman SA3.(PubMed)
(3) The relation between cigarette smoking and risk of acute myeloid leukemia: an updated meta-analysis of epidemiological studies by Fircanis S1, Merriam P, Khan N, Castillo JJ.(PubMed)

Ginger, the Heart and Blood Vessels Friendly Functional Spice

By Kyle J. Norton

Ginger may have a profound and positive effect in reducing the risk and treatment of cardiovascular disease, some studies found.

The cardiovascular disease is a medical condition associated with the heart and blood vessels, depending on the location of blood clots.

Most common causes of cardiovascular disease is atherosclerosis caused by plaque accumulated on the wall of the arteries, leading to reduced rich oxygenated blood flow to the heart, a major cause of the death of heart cells.

According to the John Hopkins statistics, approximately 84 million people in the US suffer from some form of cardiovascular disease, causing about 2,200 deaths a day, averaging one death every 40 seconds.

Sadly to know that almost one out of every three deaths results from cardiovascular disease. 

Epidemiologically, certain risk factors are found to associate with the onset of the condition, including lack of exercise, diabetes, use of tobacco, gender, genetic preposition, and excessive alcohol drinking.

However, poor diet was one of the preventable risk factors in the Western world. Researchers suggested that there is no coincidence but a correlation of the widespread cardiovascular disease in the US and the promotion of the Western diet over the past many decades.

Diet high in saturated and trans fat, red meat and processed food and few in fruits and vegetables and whole grain have a strong and positive implication in the promotion of the onset of the disease.

Dr. Sonia S. Anand, the lead scientist in the study "Food Consumption and its impact on Cardiovascular Disease: Importance of Solutions focused on the globalized food system" said, "Evidence from different countries, age/race/ethnicity/socioeconomic groups suggest the health effects studies of foods, macronutrients, and dietary patterns on CVD appear to be far more consistent though regional knowledge gaps are highlighted".

And, "Poor quality diets are high in refined grains and added sugars, salt, unhealthy fats, and animal-source foods; and low in whole grains, fruits, vegetables, legumes, fish and nuts ( are associated to the onset of CVD)"

Therefore, by teaching the general public the role of diet that can prevent CVD, the writers continued, "a healthier food supply enables individuals to make healthier choices. Developing food systems that underpin healthier dietary patterns based on our consensus noted above involves improving the food supply by producing more heart-healthy foods and fewer foods associated with CVD".

These results clearly stated, a healthy diet with high in fruits and vegetable, whole grain fewer saturated and trans fat, red meat and processed foods can substantially reduce the risk of CVD.


Ginger officinale or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to reconfirm the effects of ginger for the treatment of many aspects of cardiovascular disease, Dr. Nicoll R and colleagues conducted a study to look into ginger anti-cardiovascular disease activity.

In the animal model, application of ginger demonstrated a significant anti-inflammatory, antioxidant, antiplatelet, hypotensive and hypolipidemic effect to protect the tested animal against the onset of cardiovascular disease.

In the human trial, dosages of 5 g or more demonstrated significant antiplatelet activity.

These results suggested that ginger may have the potential to offer not only a cheaper natural alternative to conventional agents but one with significantly lower side effects.

Futhermore in the concern of the widespread of cardiovascular diseases in the Western world and the leading cause of death worldwide, researchers at the Katedra Technologii Żywienia Człowieka evaluated the effects of kitchen spice on the condition.

Ginger and the selected spices showed a strongly cardioprotective effect through their antioxidant, chemopreventive, anti-inflammatory and immunomodulatory properties.

At the final report of the study, Dr. Kulczyński B, said, "selected spices (garlic, cinnamon, ginger, coriander, and turmeric) (may be used )in the prevention and treatment of cardiovascular diseases".

Taken altogether, ginger may be considered a functional food for the prevention and combined with the primary medicine for the treatment of cardiovascular disease with no side effects.

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Ginger (Zingiber officinale Roscoe): a hot remedy for cardiovascular disease? by Nicoll R, Henein MY. (PubMed)
(2) The importance of selected spices in cardiovascular diseases by Kulczyński B1, Gramza-Michałowska A. (PubMed)
(3) Spices and Atherosclerosis by Tsui PF1,2, Lin CS3, Ho LJ4, Lai JH. (PubMed)
(4) Food Consumption and its impact on Cardiovascular Disease: Importance of Solutions focused on the globalized food system. A Report from the Workshop convened by the World Heart Federation by Sonia S. Anand,1,2,* Corinna Hawkes,3,* Russell J. de Souza,4 Andrew Mente,2Mahshid Dehghan,2 Rachel Nugent,5 Michael A. Zulyniak,1 Tony Weis,6 Adam M. Bernstein,7Ronald Krauss,8 Daan Kromhout,9 David J.A. Jenkins,10,11 Vasanti Malik,12Miguel A. Martinez-Gonzalez,13 Dariush Mozafarrian,14 Salim Yusuf,2 Walter C. Willett,12 andBarry M Popkin. (PMC)

Banana, The Potential Gastric Ulcer Healing Functional Food

By Kyle J. Norton

Banana may have a potential effect in protecting the gastrointestinal tract against the formation of gastric ulcers, some scientists suggested.

Gastric ulcers are open sores that develop on the inside lining of your stomach.

The most common cause of gastric ulcer is associated with the infection of the bacterium Helicobacter pylori (H. pylori). However, patients who are the long-term users of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) also at the higher risk of gastric ulcer.

Long-term untreated gastric ulcer can result in gastric adenocarcinoma development.

Although there are some disagreements that a poor diet can cause gastric ulcers, some researchers suggested that a diet rich, fatty or spicy foods such as the Western diet and unhealthy lifestyle such as high caffeine. and excessive alcohol consumption also elevates the onset of the disease.

Therefore by following a healthy diet with more fruits and vegetable, whole grain less red meat and processed foods accompanied by a healthy choice of lifestyle and moderate exercise, one can lower the risk gastric ulcer substantially.

Dr. the lead author in the study, "Nutritional care in peptic ulcer" wrote, "Dietotherapy, as well as caloric distribution, should be adjusted to the patient's needs aiming to normalize the nutritional status and promote healing. Recommended nutrients can be different in the acute phase and in the recovery phase, and there is a greater need of protein and some micronutrients, such as vitamin A, zinc, selenium, and vitamin C in the recovery phase. In addition, some studies have shown that vitamin C has a beneficial effect on the eradication of H. pylori. Fibers and probiotics also play an important role in the treatment of peptic ulcer, because they reduce the side effects of antibiotics and help reduce treatment time.".

These results suggested that gastric ulcer not only can be prevented by the change of diet but can also be treated by modifying the antioxidant and nutrients intake.

Banana is the common name of a genus of tropical herbaceous plants. It can grow from 3 to 9 m and belongs to the family of the lily and the orchid.

The Banaras Hindu University in the reaffirming the inflammatory cytokines expression occurred in the onset of gastric ulcer onset launched an investigation to examine the effect of a Musa sapientum fruit (banana extract, MSE) extract the acetic acid (AA)-induced gastric ulcer (GU) in diabetic (DR) rat.

Selected rat model were given MSE (100 mg/kg, oral), omeprazole (OMZ, 2.0 mg/kg, oral), insulin (INS, 4 U/kg, sc) or pentoxyphylline (PTX, 10 mg/kg, oral) once daily for 10 days in 14 days post-streptozotocin (60 mg/kg, intraperitoneal)-induced diabetic rats before the normal/diabetic rats were received CMC for the same period after induction of GU with AA.

According to the ulcer index, TNF-α and IL-1β were observed in normal (NR)-AA rat given the acetic acid (AA) compared to NR-normal rats group.. the expression of proinflammatory presentation suggested that acetic acid (AA) has caused gastric damage.

Application of Musa sapientum fruit (MSE) extract inhibited the gastric ulcer expression through significant normalizing the levels of the blood glucose and gastric mucosal cytokines, TNF-α and IL-1β and growth factor, TGF-α, compared to OMZ (antiulcer drug).

Further analysis suggested that the efficacy of Musa sapientum fruit (MSE) extract was attributed to the presence of phytochemicals saponins, flavonoids, glycosides, steroids, and alkaloids.

Dr. Kumar M, the lead scientists said, "MSE showed antidiabetic and better ulcer healing effects compared with OMZ (anti-ulcer drug)".

Additionally, in the study of the antiulcer and mucosal defensive factors effects of methanolic extract of Musa sapientum var. Paradisiaca (MSE, 100 mg/kg) in normal and non-insulin dependent diabetes mellitus (NIDDM) rats. NIDDM was induced by administering streptozotocin (STZ, 70 mg/kg, ip) to 5 days old rat pups also found that

* The effects of MSE were effective compared with the known ulcer protective drug, sucralfate (SFT, 500 mg/kg) and anti-diabetic drug glibenclamide (GLC, 0.6 mg/kg) when administered orally, once daily for 6 days against gastric ulcers (GU).

* The MSE extracts reverse the changes in gastric mucosal glycoproteins, cell proliferation, free radicals (lipid peroxidation and nitric oxide) and anti-oxidants enzymes (superoxide dismutase and catalase) and glutathione (GSH) levels induced by administering streptozotocin. 

* MSE showed better ulcer protective effect in NIDDM rats compared with SFT and GLC in CRS-induced GU

* The extracts restore the levels of the gastric mucosal glycoprotein which was reduced in the NIDDM rats without having any effect on cell proliferation.

* MSE pretreatment showed a reversal in the levels of all the parameters better than GLC.caused by the injection of streptozotocin.

Final differentiation discovered that the efficacy of MSE in the inhibition of gastric ulcers was attributed to the predominant effect on the mucosal glycoprotein, cell proliferation, free radicals, and antioxidant systems.

Taken all together, banana processed abundantly phytochemicals may be considered a functional food for the prevention and an adjunct therapy combined with the primary medicine for the treatment of gastric ulcer without inducing any side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Healing effects of Musa sapientum var. paradisiaca in diabetic rats with co-occurring gastric ulcer: cytokines and growth factor by PCR amplification by Kumar M, Gautam MK, Singh A, Goel RK1.(PubMed)
(2) Effect of plantain banana on gastric ulceration in NIDDM rats: the role of gastric mucosal glycoproteins, cell proliferation, antioxidants and free radicals by Mohan Kumar M1, Joshi MC, Prabha T, Dorababu M, Goel RK. (PubMed)
(3) Indigenous anti-ulcer activity of Musa sapientum on peptic ulcer. by Prabha P1, Karpagam T, Varalakshmi B, Packiavathy AS.(PubMed)

Honey, the Potential Chemo Replacement for the Treatment Cancers, Scientists Say

By Kyle J. Norton

Honey may process certain chemical compounds which have a potential effect in the reducing risk and treatment of cancers with no side effects, some scientists suggested.

Cancer cells are the type of cells which can grow indefinitely compared to normal cycle which can only survive after certain cycle division.

According to cellular biology, in a fully grown adult cell, the rate of cell proliferation is much less, and under normal circumstances and cell division in an adult can only occur when there is the need to replace cells that have been lost, damaged, or worn out.

Most cancers start in the cells on the surface of the inner lining of the tissue of the specific organ.

At the early stage, most cancer tumors do not induce any symptoms. However, after colonizing most tissue, the disorderly proliferative tumor can suppress the nearby tissue including nerve cells and blood vessel, causing localized pain and severe symptoms depending on the types of cancer.

Also, at this stage, malignant cells can also travel through lymph and blood to infect other healthy tissue, a distance away from the original site.

Although there are many risk factor associated with the onset of cancer, people with a genetic preposition are at highest risk.

Men who carry genetic mutation BRCA1, BRCA2, and HOXB13, inherited from the parents are at 70% risk of the prostate cancer, and women who carry the mutated genes BRCA1 and 2 have an increased risk breast cancer of over 55%.

Sadly, more than 12 percent of men with prostate cancer tested positive for hereditary mutations of cancer-causing genes, 87% of women reported BRCA testing by one-year post-diagnosis of breast cancer.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

With an aim to find a natural ingredient for the prevention and treatment of cancer with no side effects, a joint study led by the Universiti Sains Malaysia was conducted to examine the role of honey in modulating the development and progression of tumors or cancers.

By searching the available data online literature, researchers found that there is available evidence (some of which is very recent) with regards to the antimetastatic, antiproliferative and anticancer effects of honey in various forms of cancer.

Honey was highly cytotoxic against tumor or cancer cells, while it was non-cytotoxic to normal cells.

Honey inhibited growth and proliferation of tumors or cancers.

Application of honey inhibited carcinogenesis by modulating the molecular processes of initiation, promotion, and progression stages.

Furthermore, in the study to examine the honey and royal jelly effects against cisplatin-induced nephrotoxicity in patients with cancer, researchers examined the results of patients with cancer assigned for cisplatin chemotherapy randomly divided into bee honey and royal jelly groups pretreated before the initiation and during cisplatin chemotherapeutic regimen and control group on cisplatin only and showed that

* Patients on crude bee honey and royal jelly capsules showed lower serum levels of renal injury products (creatinine and urea) compared to those in the control group.

* The changes in kidney parameters were significantly (p < 0.05) lower when compared within the bee honey group before and after cisplatin treatment.

These results indicated bee honey and royal jelly as natural compounds are effective in reducing cisplatin nephrotoxicity and may offer a promising chance for clinically meaningful prevention with no side effects.

Interestingly, Dr. the lead author in the examine the overwhelming evidence of the role of diet and lifestyle in cancer risk and prevention, suggested that there is a growing interest into the search for chemopreventative or chemotherapeutic agents derived from natural products.

And, honey is an important source of bioactive compounds derived from plants and recent years have been under the intensified study for its anticancer properties. 

Recently, the role of honey in targeting key hallmarks of carcinogenesis, including uncontrolled proliferation, apoptosis evasion, angiogenesis, growth factor signaling, invasion, and inflammation has been presented. in numbers of conventional research.

Taken altogether, honey may be used as a functional food for the prevention of cancers and a secondary therapy combined with conventional medicine for the treatment of cancers.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Effects of honey and its mechanisms of action on the development and progression of cancer by Erejuwa OO1, Sulaiman SA2, Wahab MS. (PubMed)
(2) Effect of Honey and Royal Jelly against Cisplatin-Induced Nephrotoxicity in Patients with Cancer by Osama H1, Abdullah A1, Gamal B1, Emad D1, Sayed D1, Hussein E1, Mahfouz E1, Tharwat J1, Sayed S1, Medhat S1, Bahaa T1, Abdelrahim MEA. (PubMed)
(3) Honey and Cancer: Current Status and Future Directions by Porcza LM1, Simms C2, Chopra M. (PubMed)

Ginger, The Spice Which Protects Our Body Against Inflammatory Diseases

By Kyle J. Norton

Scientists may have found a pungent and kitchen spices which process a potential effect on the prevention and treatment of chronic inflammatory diseases without inducing any side effects.

Inflammation is a natural reaction of the immune system whose function is to protect our body against the invasion of the foreign stimuli and pathogens.

In the acute phase of tissue damage or injury, the white blood cells responsible for the first line of defense activate the production of the inflammatory cytokines to the site of infection with an aim to kill off the invasive agents.

However, in most cases, overproduction of inflammatory cytokines can damage the nearby cells and lead to improper healing with the formation of scars.

Chronic inflammation is an inflammation that lasts more than 3 months. The development and progression of chronic inflammatory diseases are the results of the immune system which can not kill off the invasive pathogens in the acute phase of infection or immune system mistakenly attacks the body tissue, leading to the persistently the low-grade inflammation.

In the further analysis of the evolution of physiological supersystems involved chronic inflammatory disease, Dr. Rainer H. Straub, the lead author said, "It is predicted that genes that protect energy stores are positively selected (as immune memory). This could explain why energy-demanding inflammatory episodes like infectious diseases must be terminated within 3–8 weeks to be adaptive, and otherwise become maladaptive:

These results suggested that the genes and networks used evolved during physiological supersystems, fitness consequences and during different life-history stages are positively selected if they serve acute, highly energy-consuming inflammation.

In other words, the immune system becomes maladaptive, if an inflammation does not terminate within eight weeks of infection.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The kitchen has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On finding a natural ingredient for the treatment of inflammation without inducing any adverse effects, a joint study led by the CHA University, Seongnam was conducted to examine the molecular mechanism of 6-gingerol on adipocyte-mediated systemic inflammation in vitro and in high-fat-diet-induced obese zebrafish.

Injection of 6-gingerol exerted a significantly increased the production of anti-inflammatory cytokine interleukin-10 and decreased the expression of proinflammatory cytokines, TNFα, monocyte chemotactic protein-1, interleukin-1β, and interleukin-6.

In the RAW 264.7 macrophages, 6-gingerol inhibited the protein expression of proinflammatory factors TNFα and monocyte chemotactic protein-1, a small cytokine that belongs to the CC chemokine family.

6-Gingerol decreased c-JUN N-terminal kinase and I kappa B kinase beta which plays an important role in the inhibition of nuclear factor kappa-B kinase activated by multiple stimuli such as inflammatory cytokines

Where JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes including inflammation.

6-gingerol also decreased the expression of inducible nitric oxide synthase in the stimulation of the expression of inflammation.

Dr. Choi J, the lead scientists wrote in the final report, " 6-gingerol suppresses inflammation through the regulation of the c-JUN N-terminal kinase-I kappa B kinase beta and its downstream targets".

Furthermore, the investigation of the effects of 6-gingerol ((S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone) in experimental models that HepG2 cells were exposed to 500 µmol/l oleic acid (OA) for 24 h and preincubated for an additional 24 h with 6-gingerol (25, 50 or 100 µmol/l). 6-Gingerol (100 µmol/l) inhibited OA-induced triglyceride and inflammatory marker accumulation in HepG2 cells of non-alcoholic steatohepatitis also suggested that

* Daily application of 6ginger for 8 weeks while maintained on HFD. 6-Gingerol (100 mg/kg/day) alleviated liver steatosis, inflammation, and reversed 

* [6]-gingerol also attenuated the expression of inflammatory cytokine genes and nuclear transcription factor-κB (NF-κB) increased in the HFD group.

The results strongly indicated 6-Gingerol attenuates HFD-induced steatohepatitis by downregulating NF-κB-mediated inflammatory responses and reducing hepatic lipogenic gene expression.

More interestingly, in the study includes five groups of rats containing 14 rats/group received corn oil (control), CPF (5 mg/kg), 6-GRF (100 mg/kg), CPF (5 mg/kg) + 6-GRF (50 mg/kg) and CPF (5 mg/kg) + 6-GRF (100 mg/kg) through gavage once per day for 35 days respectively, researchers showed that

* Before 6-gingerol application CPF-induced rats showed an increase in oxidative stress ((hydrogen peroxide (H2O2) and malondialdehyde (MDA)), inflammatory (myeloperoxidase (MPO), nitric oxide (NO) nitric oxide (NO) and tumor necrosis factor-α (TNF- α)), and apoptotic (caspase-3) markers.

* Injection of 6-gingerol attenuated all factors in the CPF induced rats.

* 6-GRF reduced the inflammatory expression through improving the activities of antioxidant enzymes catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione S-transferase (GST) as well as glutathione (GSH) level in the brain, ovary, and uterus of rats exposed to CPF.

Dr. Abolaji AO the lead author said, " the protective effects of 6-GRF on CPF-induced toxicity in the brain and reproductive organs of rats may be due to it's potent antioxidative, anti-inflammatory and antiapoptotic properties".

Where Chlorpyrifos (CPF) is an organophosphorus pesticide widely used in agricultural applications and household environments.

Taken all together, ginger processed abundantly 6-gingerol may be considered a functional kitchen spice for the prevention and treatment of inflammation.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 6-Gingerol Suppresses Adipocyte-Derived Mediators of Inflammation In Vitro and in High-Fat Diet-Induced Obese Zebra Fish by Choi J1, Kim KJ1, Kim BH2, Koh EJ1, Seo MJ1, Lee BY. (PubMed)
(2) [6]-gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis by Tzeng TF1, Liou SS1, Chang CJ1, Liu IM. (PubMed)
(3) Protective properties of 6-gingerol-rich fraction from Zingiber officinale (Ginger) on chlorpyrifos-induced oxidative damage and inflammation in the brain, ovary, and uterus of rats by Abolaji AO1, Ojo M2, Afolabi TT2, Arowoogun MD2, Nwawolor D2, Farombi EO. (PubMed)

Tualang honey Protects the Oral Cells Against the Onset of Mouth Cancer With No Side Effects

Kyle J. Norton

Mouth/oral cancer is a medical condition associated with the irregular cell growth on the tissue of the mouth caused by genetic alteration of the cell DNA.

Most cases of mouth cancer start in the flat, thin cells (squamous cells) of the inner lining tissue that line the lips and the inside of the mouth.

According to the statistics provided by the American cancer society, in 2018, approximately, over 50,000 people will get oral cavity or oropharyngeal cancer. An estimated over 10,000 people will die of these cancers.in the United States.

The exact causes of mouth cancer are unknown. However, the increase in age, gender, exposure to radioactive, long-term use of tobacco use and excessive alcohol drinking, viral infection and genetic mutation are the most common prevalent risk factors found in people with mouth cancer.

Some researchers also suggested that people with immune system suppression due to the use of an immune suppressor are at the increased risk of the disease.

The Canadian Cancer Society in the explanation of how weakened immune system can induce mouth cancer, wrote, "Your immune system can be weakened after an organ transplant or treatment for an immune system disease. and "People with a weakened immune system have a higher risk of developing oral cancer, especially lip cancer".

Also, " The higher risk may be due to taking drugs that suppress your immune system. People with weakened immune systems are also more likely to get an HPV infection, which increases the risk of oral cancer"

If you experience symptoms of a sore that does heal  within a few days, a growth, lump or thickening of the skin or lining of your mouth, tongue and jaw pain that do not heal in weeks, persistent sore throat, difficult or  chewing and swallowing, please check with your doctor to rule out the possibility of mouth cancer.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient or whole food for the treatment of t inducing mouth cancer without inducing any side effect compared to surgery followed by chemo and.or radiotherapy researchers at the Universiti Sains Malaysia examine the antiproliferative activity of local honey (Tualang) on OSCC cell lines.

The study procedures include several concentrations of Tualang honey (1% - 20%) were applied directly on OSCC cell lines for 3, 6, 12, 24, 48 and 72 hours.

The study also used MTT assay to assess the cell viability and the Annexin V-FITC Apoptosis Detection Kit.to detect the cell apoptosis.

Application of Tualang honey induced cancer cells apoptosis observed by cell degradation and reduced in numbers.

In other words, the apoptotic cellular changes like becoming rounded, reduction in cell number, blebbed membrane and apoptotic nuclear changes like nuclear shrinkage, chromatin condensation, and fragmented nucleus were observed through MTT assay.

The MTT assay also suggested that Tualang honey exerts an inhibitory effect in a time and dose-dependent manner.

The efficacy was also found in the 50% inhibitory concentration (IC50) for OSCC of 4%.

The maximum inhibition of cell growth of ≥80% was observed in the concentration at 15%.

Dr. Ghashm AA the lead scientist at the final report wrote, "Tualang honey showed the antiproliferative effect on OSCC...cell lines by inducing early apoptosis".

Taken altogether, Tualang honey may be considered a functional food for the prevention and combined with the primary medicine for the treatment of mouth cancer.

Due to the limitation of the above study, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of Tualang honey anti-mouth cancer possibilities.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines by Ghashm AA1, Othman NH, Khattak MN, Ismail NM, Saini R.(PubMed)

Black beans Protect Your Large Intestine Against Colon Cancer

By Kyle J. Norton

Black bean may have a profound effect in reducing and treatment of colon cancer, some scientists suggested.

The colon also known as the large bowel or large intestine, is the part of the digestive system in our body.

Colon cancer is a chronic condition caused by the cell growth irregularly and disorderly in the colon due to the alternation of DNA.

Most cases of colon cancer start in the cells on the surface of the inner lining of the colon. At this stage, patients may not experience any symptoms.

After penetrating deeper into the colon layer, the cancer cells may travel a distance away to infect other healthy tissue and organs through the fluids and blood circulation.

At this stage, the increased size of the tumor may suppress the nearby tissue, organs or nerves cells causing localized symptoms and severe pain.

Most common colon cancer metastasis are the lungs, liver.

According to the epidemiological studies, the most common risk factors of colon cancer are older

age, ethnicity, personal and family history of colorectal cancer or polyps, inflammatory intestinal conditions.

Particularly, people who follow the low-fiber, high-fat diet or have a sedentary lifestyle. are associated with the substantial risk for the onset of the disease.

Dr. Y J Cong, the lead author in the concerns of the sedentary behavior in risk of colon cancer in modern society, launched an investigation to examine the association of sedentary behavior with colon and rectal cancer.

The search of the databases of PubMed, Embase, and Google Scholar databases up to May 2013 to identify cohort and case-control studies that evaluated the association between sedentary behavior and colon or rectal cancer identified 23 studies with 63 reports included 4 324 462 participants.

After assessing the results of all the studies, the doctor team wrote. "Sedentary behavior is associated with an increased risk of colon cancer. Subgroup analyses suggest a positive association between sedentary behavior and risk of rectal cancer in cohort studies".

Black bean is a Small roughly ovoid legume with glossy black shells, genus Phaseolus, belonging to the family Fabaceae.

The bean can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

The major chemical compounds of black bean include anthocyanin, (-)-epicatechin, delphinidin, petunidin, flavonols, and malvidin.

On finding, a natural whole food for the treatment of colon cancer, researchers at the Tecnológico de Monterrey-Campus Monterrey conducted an investigation to examine the black bean antioxidant capacity and antiproliferative activity against cancer cell lines.

Flavonoids extracted from seed coats exerted a potential effect against colon cancer cell line'

The extracts obtained from seed coats after 3 and 5 germination days inhibited all cancer cell lines proliferation, including the tested colon cancer with no cytotoxicity against control cells.

Further analysis also suggested that flavonols and group B saponins isolated from the seed coat were more related to hepatic and colon cancers.

These results indicated that not all chemical compounds found in black bean have a potential effect in the inhibition of colon cancer. However, intake of the black bean as a whole food may have significant effects in reducing the risk of colon cancer.

Additionally, in the finding evidence to suggest an inverse relationship between bean consumption and colon cancer, researchers at the Food Science program at the Michigan State University conducted a study to determine whether consumption of black beans and/or navy beans would reduce colon carcinogenesis in rats.

Selected rat group were fed a modified AIN-93G diet (control) or diets containing 75% black beans or 75% navy beans for 4 wk, and then colon cancer was initiated by the administration of two injections of azoxymethane 1 wk apart.

At 31 wk after the second injection, the incidence of colon adenocarcinomas was significantly lower in rats fed the black bean (9%)  than in rats fed the control diet (36%).

Total tumor multiplicity was also significantly lower in rats fed the black bean diet than in rats fed the control diet.

After taking into account co and confounders, Dr. Hangen L, the lead author said, "The 44-75% reduction in colon carcinogenesis in rats fed beans was attributed to 1) more controlled appetites, leading to significantly less body fat, and 2) much greater concentrations of butyrate in the distal colon".

These results suggested black beans only have a potential effect in lowering the risk of colon cancer.  but also stop cells multiplicity in the case of colon cancer.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of black bean anti-colon cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Differential accumulation of polyphenolics in black bean genotypes grown in four environments.
Marles MA, Balasubramanian P, Bett KE. (PubMed)
(2) Evaluation of the antioxidant and antiproliferative activities of extracted saponins and flavonols from germinated black beans (Phaseolus vulgaris L.).
Guajardo-Flores D, Serna-Saldívar SO, Gutiérrez-Uribe JA(PubMed)
(3) Consumption of black beans and navy beans (Phaseolus vulgaris) reduced azoxymethane-induced colon cancer in rats. by Hangen L, Bennink MR. (PubMed)
(4) Association of sedentary behavior with colon and rectal cancer: a meta-analysis of observational studies by bY J Cong,1 Y Gan,1 HL Sun,1 J Deng,1 S Y Cao,1 X Xu,1,2 and Z X Lu. (PubMed)