#Ginger Inhibits Stress Markers Associated with the Risk and Onset of Type 2 #Diabetes, Scientists Say

Kyle J. Norton

Ginger may be next generation whole food used for the prevention and treatment of type 2 diabetes, with no side effects, some scientists suggested.

Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose due to either cell in pancreas dying off or receptor sites clogged up by fat and cholesterol.

Researchers do not know what causes the pancreas to die off or receptor sites to clog up. However, they do know obesity or overweight, gender, ethnicity, age, family history, gestation diabetes, are associated with an increased risk of type 2 diabetes.

Some researchers also suggested that people with certain medical conditions such as polycystic ovary syndrome. and high blood pressure is more prone to the onset of the disease.

The most common symptoms of type 2 diabetes are increased thirst that won't stop with water intake, increased hunger (especially after eating), dry mouth, frequent urination, and unintentional weight loss.

If you experience some of the symptoms above, please make you check with your doctor to rule out the possibility of diabetes.

According to statistics, diabetes is one of the most common diseases in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million that are undiagnosed and unaware of their condition.

About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.

Dr. Rita R. Kalyani in the study to examine the increase with age and risk of type 2 diabetes wrote, "The unprecedented aging of the world's population is a major contributor to the diabetes epidemic, and older adults represent one of the fastest-growing segments of the diabetes population".


"Almost one-third of U.S. adults over the age of 65 years have diabetes. Approximately half of those are undiagnosed, and an additional one-third of older adults have prediabetes" and "management of older adults with diabetes is clearly more complicated given the observation that they commonly have multiple coexisting medical conditions that can impact clinical management".

Compared to the general population risk of type 2 diabetes, the results clearly stated, the risk of type diabetes in elderly is 3 fold higher and the management of the disease is more difficult due accompanied by other medical conditions, such as high blood pressure and cholesterol

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

To find a natural whole food for the prevention and treatment of diabetes with little or no side effects, researchers looked into the effects of ginger consumption on glycemic status, lipid profile, and some inflammatory markers in patients with type 2 diabetes mellitus.


The double-blinded, placebo-controlled clinical trial, included 70 types 2 diabetic patients allocated randomly into the ginger group consumed 1600 mg of ginger, and the control group consumed 1600 mg of wheat flour daily for 12 weeks.

Patients treated with ginger demonstrated a significant effect in reducing the levels of fasting plasma glucose, 3 months average glucose concentration, and insulin resistance.

Furthermore, the blood profile of the treatment group also displayed lower levels of triglyceride, total cholesterol, a hormone associated with lipid peroxidation. compared to the placebo group.

There were no significant differences in high-density lipoprotein (HDL), low-density lipoprotein LDL, and TNFα, the inflammatory cytokine between the two groups.

The findings firmly indicated ginger improves insulin sensitivity and some fractions of lipid profiles and reduces inflammation in type 2 diabetic patients.


Additionally, intending to reaffirm the effects of ginger against the development of type 2 diabetes and diabetic complications, researchers investigated the effect of ginger supplementation on glycemic indices in Iranian patients with type 2 diabetes.

The double-blind, placebo-controlled, randomized clinical trial included 20-60 -year-old patients with type 2 diabetes who did not receive insulin.

Participants in the intervention and control groups received 3 g of powdered ginger or placebo (lactose) (in capsules) daily for 3 months.


At the end of the 3 months, researchers showed that all parameters associated with diabetes were reduced substantially in the treatment group compared to control.

More precisely, the differences between the ginger and placebo groups were statistically significant as follows: serum glucose (-19.41 ± 18.83 vs. 1.63 ± 4.28 mg/dL, p < 0.001), (Hemoglobin A1C)HbA1c percentage (-0.77 ± 0.88 vs. 0.02 ± 0.16%, p < 0.001), insulin (-1.46 ± 1.7 vs. 0.09 ± 0.34 μIU/mL, p < 0.001), insulin resistance (-16.38 ± 19.2 vs. 0.68 ± 2.7, p < 0.001), high-sensitive CRP (-2.78 ± 4.07 vs. 0.2 ± 0.77 mg/L, p < 0.001), paraoxonase-1 (PON-1) (22.04 ± 24.53 vs. 1.71 ± 2.72 U/L, p < 0.006), total antioxidant capacity (TAC) (0.78 ± 0.71 vs. -0.04 ± 0.29 µIU/mL, p < 0.01) and MDA (-0.85 ± 1.08 vs. 0.06 ± 0.08 µmol/L, p < 0.001) were significantly different.

Where paraoxonase ((PON)-1 is an enzyme associated with the protection against lipid oxidation, Malondialdehyde (MDA) is an oxidative stress marker.

Dr. Shidfar F, the lead scientist said, "The 3 months supplementation of ginger improved glycemic indices, TAC, and PON-1 activity in patients with type 2 diabetes".

Taken together, ginger may be considered a functional food for the prevention and combined with the primary therapy for the treatment of type 2 diabetes with no side effects.

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus by Arablou T1, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. (PubMed)
(2) Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients by Mahluji S1, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. (PubMed)
(3) The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes by Shidfar F, Rajab A, Rahideh T, Khandouzi N, Hosseini S, Shidfar S. (PubMed)
(4) Diabetes and Aging: Unique Considerations and Goals of Care, Rita R. Kalyani, Sherita H. Golden and William T. Cefalu. (Diabetes Care)

#Healthyfood #Tomato Inhibits the Risk and #Onset of Digestive-Tract Cancer, Researchers Show

Kyle J. Norton

Digestive-tract formed part of the digestive system is a series of hollow organs joined in a long, twisting tube from the mouth to the anus and plays a critical role to absorb the nutrient from the food intake to the blood before passing them to other parts of the body.
Cancers are a class of diseases characterized by irregular cell growth in the body tissue.

Most cases of digestive tract cancer start in the cell on the surface of the inner lining of the gastrointestinal tissue before penetrating into deeper layers and colonizing the entire organ.


Colon cancer is one of the most common and slow-growing cancers in the digestive tract that

According to the statistics provided by the American Cancer Society, in 2019, 95,520 people will be diagnosed with colon cancer. Colon cancer will also cause the death of 50,260 patients in the same year.

The 5 years survival rate of colon cancer diagnosed at the localized stage is 90%.

The most common signs of digestive tract cancer include abdominal pain, blood in the stool due to bleeding, and a noticeable lump in the abdomen accompanied by the general symptoms shared with other types of cancer such as unexplained weight loss, weakness or fatigue gastrointestinal discomfort, and loss of appetite.

If you have experienced some of the aforementioned symptoms with no signs of stopping, please make sure you check with your doctor to rule out the possibility.

WHO in the examination of diet in cancer risk wrote, "Cancer is the most important cause of death after diseases of the circulatory system. It accounts for 20% of all deaths in the Region, with 2.5 million new cases diagnosed each year".

And, "A large body of literature indicates that as much as 30% of all cancer cases are linked to poor dietary habits, and is therefore preventable. The proportion reaches 70% for cancers of the gastrointestinal tract".

In other words, poor diet is one of the major causes of gastrointestinal cancer worldwide.

Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.


In the urgency to find a potential compound for the treatment of digestive tract cancer, researchers examined the relationship between tomato intake and the risk of digestive tract cancer.

According to the data from a series of case-control studies conducted in Italy between 1983 and 1992, over the period, 317 incident cases of cancer of the oral cavity and pharynx, 85 of the esophagus, 723 of the stomach, 955 of the colon, and 629 of the rectum, were diagnosed compared to a total of 2879 controls admitted for acute, non-neoplastic conditions, unrelated to long-term modifications of diet.

The ORs for the highest tomato consumption quartile were 0.65 (95% CI 0.4-1.0) for oral cavity, pharynx, and esophagus, 0.43 (95% CI 0.3-0.6) for stomach, 0.39 (95% CI 0.3-0.5) for colon, and 0.42 (95% CI 0.3-0.6) for rectum.

The ORs of colorectal cancer for the highest consumption quintile were 0.79 (95% CI 0.6-0.9) for colon and 0.71 (95% CI 0.5-0.9) for rectal cancer, according to another study of colorectal cancer, based on 1,953 cases and 4,154 controls, conducted between 1992 and 1996, using a more detailed food frequency questionnaire.

The findings strongly suggested that a long-term high amount of tomato consumption has a strong impact on the risk of digestive tract cancer, regardless of several potential confounding factors, including measures of body mass index, calorie intake, and physical activity.

Furthermore, to examine the additional information about tomato anti-digestive-tract cancers, researchers investigated the effect of tomatoes on the risk of digestive tract tumors based on an integrated series of case-control studies conducted between 1985 and 1991 in northern Italy, where tomato intake is high but, also, heterogeneous.

For 7 years, the oral cavity and pharynx, 314; the esophagus, 85; stomach, 723; colon, 955; and rectum, 629 were diagnosed compared to a total of 2,879 controls admitted to the hospital for acute non-neoplastic or non-digestive conditions, unrelated to long-term dietary modifications.

The OR of digestive tract cancers in the upper quartile was ranging between 0.4 and 0.7 compared to the baseline.

Researchers after allowance for age, sex, study center, education, smoking, drinking level, and tertile of total caloric intake into account said, "The beneficial effect of raw tomatoes in this population may be partly since they constitute perhaps the most specific feature of the Mediterranean diet".

And, " However, if it is true that tomatoes protect against digestive tract cancers, this is of interest from both a scientific and a public health viewpoint".

Taken together, tomatoes may be considered supplements for the prevention and treatment of digestive tract cancers, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Mediterranean epidemiological evidence on tomatoes and the prevention of digestive-tract cancers by La Vecchia C. (PubMed)
(2) Tomatoes and risk of digestive-tract cancers by Franceschi S1, Bidoli E, La Vecchia C, Talamini R, D'Avanzo B, Negri E. (PubMed)
(3) Cancer linked with poor nutrition by WHO

#FennelExtract Inhibits Neurotoxicity Against The Onset of Cognitive Impairment, Scientists Suggest

Kyle J. Norton

Fennel may process a sustainable and therapeutic effect in enhancing cognitive functions, some scientists suggested.
Cognitive function is a mental process of the brain, intending to acquire knowledge by accumulating information through reasoning, memory, attention, and language, regardless of circumstances.

On the other hand, cognitive impairment, depending on the severity is a condition in which the infected person has trouble remembering, learning new things, concentrating, or making decisions that affect the quality of their everyday life.


In the elderly, most cases of cognitive impairment are associated with neurodegenerative diseases and long-term use of medication, including Alzheimer's disease.


However, malnutrition, hormone imbalance such as thyroid hormone, mental illness, and substance abuse, particularly, in brain damage or injury are some of the major and prevalent risk factors that can cause the early onset of cognitive impairment.


Some researchers suggested that for people who have metabolic syndrome (abnormally high blood pressure, high blood sugar, obesity, and abnormal cholesterol or triglyceride levels), mental illness, and previously disturbed state of mind due to fever, intoxication is also at a higher risk of the condition develops.


Dr. Fernando Gómez-Pinilla, in the study of the effects of nutrients on brain function, wrote. "diets that are high in saturated fat are becoming notorious for reducing molecular substrates that support cognitive processing and increasing the risk of neurological dysfunction in both humans and animals"

And, Dr. Alan J. Gow, the lead scientist, in the study of the effects of lifestyle on cognitive impairment, said, " Lifestyle factors, particularly those which are malleable across the life course, may be highly informative for the development of interventions to reduce or delay age-related cognitive decline".


These explanations strongly agree that following a healthy diet with plenty of fruits and vegetables and less saturated and trans fat, processed meat, refined products,...... salt, and sugar, and a lifestyle with moderate exercise may have a significant effect in protecting the brain neurons against the onset of cognitive impairment.

Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.

The herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
.
Anethole, the main fragrance and bioactive compound of fennel, in the study of 20 other plant species was found to process nootropic activity in protecting the degeneration of the neurons, including diseases associated with a decline in cognitive abilities such as Alzheimer's disease through its anti-inflammatory and neuroprotective expression.

In the inflammatory expression, the application of anethole exerted a significant effect in mediated NF-kB in the systematic inflammatory response induced by transcription of proinflammatory genes and TNF-α signaling in the production of inflammatory factors in the acute phase of infection.

The initiation of the pro-inflammatory cytokine in the case of acute infection is a natural defense of the immune response to protect the injured tissue against the invasion of bacteria and viruses. However, overexpression of inflammatory factors may also catalyze tissue damage and cause neuron cell death.

From an oxidative perspective, the application of anethole in the tested model also demonstrated a strong effect in inhibiting reactive oxygen species ROS which cause the cytotoxicity to neuron through its antioxidant and stimulated the production of the host antioxidant defense.


Injection of anethole also rebalanced the ratio of levels of free radicals and antioxidants, thus reducing the risk of the initiated production of pro-inflammatory cytokines in the precipitation of the death of the brain cell that controls memory or other cognitive functions.

Furthermore, in the evaluated fennel effect in Alzheimer's disease, a neurodegenerative disorder associated with a decline in cognitive abilities, researchers found that fennel intake exerts a strong neuroprotective effect in protecting against progressive degeneration.

The methanol extract of the whole plant of F. vulgare administered for eight successive days ameliorated the deficit of memory caused by brain damage, disease, or psychological trauma induced by scopolamine and aging-induced memory deficits in mice.

In acetylcholinesterase AChE-induced neurotoxicity in mice, the application of extract also increased step-down latency and reserved the neuron damage caused by acetylcholinesterase AChE toxicity.

Dr. Preksha Dwivedi, the lead author, after taking into account other co and confounders said, "Foeniculum vulgare Linn. The extract is used as a nootropic and anticholinesterase agent in mice. F. vulgare extract increased step-down latency and acetylcholinesterase inhibition in mice significantly. F. vulgare is employed in the treatment of cognitive disorders such as dementia and Alzheimer's disease".

Taken together, fennel, fennel extracts, or its bioactive anethole may be considered a functional food for enhancing memory or other cognitive functions through its neuroprotective and nootropic activity. However, intake of fennel extracts should be taken with extreme care in the prevention of acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Cholinergic basis of memory-strengthening effect of Foeniculum vulgare Linn by Joshi H1, Parle M.(PubMed)
(2) A TRADITIONAL APPROACH TO HERBAL NOOTROPIC AGENTS: AN OVERVIEW Preksha Dwivedi, Richa Singh, Mohd.Tabish Malik and Talha Jawaid(International Journal of Pharmaceutical Science and Research)
(5) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
(4) Anethole and Its Role in Chronic Diseases by Aprotosoaie AC1, Costache II2, Miron A3.(PubMed)
(5) Brain foods: the effects of nutrients on brain function by Fernando Gómez-Pinilla. (PMC)
(6) Lifestyle Factors and Cognitive Ageing: Variation across Ability and Lifestyle Domains by Alan J. Gow, Allison A. M. Bielak, and Denis Gerstorf. (PMC)

#GelamHoney and #GingerExtract Used Alone Or Combination Process a Strong Anti-Colon Cancer Activity, Researchers Say

Kyle J. Norton

Scientists may have found a sweet functional food that processes the potential for the prevention and treatment of cancer, some studies suggested.
Cancers are a group of chronic diseases, caused by cell growth and uncontrollably in some specific tissues and organs.

Most primary cancers start in the cells on the surface of the inner lining of tissue caused by the alternation of DNA.

At the later stage, after penetrating deep into the tissue of the infected organs, most primary cancers can travel a distance away from the original site to damage other healthy tissue and organs.

As they grow large enough, they can also suppress the nearby tissue and nerve cells, causing severe pain and localized symptoms.

Researchers do not know the exact causes of colon cancer. Neither do they know why some people have the same health conditions, diet patterns ethnicity, and family history, some are susceptible to the early onset of the diseases, while many others are not.

The most common risk factors, epidemiologically are associated with the types of cancer. The National Cancer Institute suggested that aging, tobacco, long-term sun and radiation exposure, chemicals and other substances, some viruses and bacteria, certain hormones, family history of cancer, alcohol, poor diet, lack of physical activity, or being overweight are the common causes of cancer.

In the challenges, the idea that cancer cannot be prevented among older adults, researchers at the National Center for Chronic Disease Prevention and Health Promotion launched a study by examining different aspects of the relationship between age and cancer said, "Although the sequential patterns of aging cannot be changed, several age-related factors that contribute to disease risk can be".

What are the age-related factors that contribute to cancer changes? researchers continued. "For most adults, age is coincidentally associated with preventable chronic conditions, avoidable exposures, and modifiable risk behaviors that are causally associated with cancer", and "current evidence suggests that for most adults, cancer does not have to be an inevitable consequence of growing older. Interventions that support healthy environments, help people manage chronic conditions, and promote healthy behaviors may help people make a healthier transition from midlife to older age and reduce the likelihood of developing cancer:

These results further emphasized the need to prevent chronic diseases support a healthy environment and promote a healthy lifestyle in the transition from midlife to the older age are the most important factors that can reduce substantially the risk of cancer.

Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.

To find a natural ingredient without side effects for the treatment of colon cancer, researchers at the Universiti Kebangsaan Malaysia, launched an investigation to examine the anti-tumor and anti-inflammation properties of crude ginger extract and Gelam honey against many types of cancer, including colorectal cancer.

The cells used in the experiment were divided into 4 groups: the first group represented HT29 cells without treatment, the second and third groups were cells treated singly with either ginger or Gelam honey, respectively, and the last group represented cells treated with ginger and Gelam honey combined.

Combined ginger and Gelam honey treatment stimulated the early cell death response by enhancing the function of proteins associated with programming cell death, namely, the caspase 9 and IκB genes, and inhibiting the function of proteins associated with cell proliferation.

The IC50 of ginger and Gelam honey alone were 5.2 mg/ml and 80 mg/ml, respectively also demonstrated similar efficacy as the IC50 of the combination treatment of 3 mg/ml of ginger plus 27 mg/ml of Gelam honey.

These results suggest ginger and Gelam honey used alone or in combination may be an effective chemopreventive and therapeutic strategy for inducing the death of colon cancer cells.


Further differentiation of the anti-proliferative effects of ginger and Gelam honey and their efficacy in enhancing the anti-cancer effects of 5-FU (5-fluorouracil) against a colorectal cancer cell line, HCT 116. researchers showed that
* Ginger (IC50 of 3mg/mL) is more potent than Gelam honey (IC50 of 75 mg/mL) in inhibiting the growth of HCT 116 cells.

* Combined treatment (35 mg/mL) of the two compounds (3mg/mL ginger+75 mg/mL Gelam honey) synergistically lowered the IC50 of Gelam, honey, to 22 mg/mL without reducing the inhibitory effect against colon cancer cell line.

* Gelam honey markedly enhanced 5-FU inhibiting effects on the growth of HCT 116 cells.

Subsequent analysis on the induction of cellular apoptosis also suggested the individual treatment of ginger and Gelam honey produced higher apoptosis compared to 5-FU alone.

These results once again suggested that Gelam honey and ginger extract used alone or in combination could potentially enhance the chemotherapeutic effect of 5-FU against colorectal cancer.

Taken altogether, honey used alone or combined with ginger might process significant and profound effects in reducing the risk of colon cancer and combined with primary therapy for the treatment of colon cancer.

However, further data collection large example size and multi-center studies performed with human consumption of whole food or its bioactive compounds during the disease will be necessary to complete the picture of honey anti-cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells by Tahir AA1, Sani NF2, Murad NA3, Makpol S4, Ngah WZ5, Yusof YA. (PubMed)
(2) Gelam honey and ginger potentiate the anticancer effect of 5-FU against HCT 116 colorectal cancer cells by Hakim L1, Alias E, Makpol S, Ngah WZ, Morad NA, Yusof YA. (PubMed)
(3) Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells by Tahir AA1, Sani NF2, Murad NA3, Makpol S4, Ngah WZ5, Yusof YA. (PubMed)
(4) Age and Cancer Risk by A Potentially Modifiable Relationship
Mary C. White, ScD, Dawn M. Holman, MPH, Jennifer E. Boehm, MPH, Lucy A. Peipins, PhD, Melissa Grossman, MPH, and S. Jane Henley, MSPH. (PMC)

#Sulforaphane Found in #Broccoli Slows the Progression of Hepatic Lipidosis Associated with #LiverDiseases, Researchers Show

Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing it to other parts of the body.

The liver also produces cholesterol, a waxy substance that aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Liver disease is a class of medical conditions characterized by reducing partly or completely the function of the liver, including liver failure.


A fatty liver is a liver condition associated with the accumulation of excess fat in the liver.

Non-alcoholic fatty liver (NAFL) is the early stage of nonalcoholic steatohepatitis (NASH) caused by the accumulation of fat in the liver, other than excessive use of alcohol.

Nonalcoholic steatohepatitis (NASH) is a type of inflammatory non-alcoholic fatty liver disease caused by excessive fat accumulated in the liver.

Nonalcoholic steatohepatitis (NASH) is asymptomatic until the condition is developed into cirrhosis, the condition that causes advanced liver scars, and reduces the performance of the liver.

In other words, if more than 5% – 10% percent of your liver’s weight is fat, you have a fatty liver (steatosis).
The prevalence rate of non-alcoholic fatty liver disease (NAFLD) among the more affluent regions of China, is approximately 15%. The number may decrease substantially if the poor rural populations where obesity is non-existence are also taken into account.

In the US, over 100 million people have non-alcoholic fatty liver disease and the condition has doubled over the past 20 years. Today, the disease is also prevalent in liver disease in children.

Most people at the early stage of NAFLD are asymptomatic. However, as the disease progresses into the later stage, most patients experience symptoms of right upper abdominal discomfort, fatigue, and/or malaise, and jaundice(20) with yellowing of the skin and eyes.

Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

To find a natural food for the prevention and treatment of liver diseases, researchers examined the effect of dietary broccoli protects against fatty liver development.

The study included male 15-day-old C57BL/6J mice that were given DEN and placed on a Western or Western+10% Broccoli diet from the age of 4 weeks through 7 months. before exposure to the hepatocarcinogen diethylnitrosamine (DEN).

According to the results of the analysis,* Dietary broccoli decreased hepatic triacylglycerols, NAFLD, liver damage, and tumor necrosis factor by month 5 without changing body weight or relative liver weight induced by hepatocarcinogen diethylnitrosamine (DEN).

* However, broccoli feeding did not have low liver carcinogenesis, observed in 100% of tested mice.

Based on the results, researchers wrote, " We conclude that broccoli, a good source of sulforaphane, slows the progression of hepatic lipidosis, but not tumourigenesis in this robust model".

Taken together, broccoli may be considered functional food for the prevention of fatty liver, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary broccoli protects against fatty liver development but not against progression of liver cancer in mice pretreated with diethylnitrosamine by Chen YJ1, Myracle AD1, Wallig MA2, Jeffery EH. (PubMed)

#Healthyfood #Onion Exhibits Anti-Hypertensive Property through Its Antioxidant Expression, According to Studies

Kyle J. Norton

Hypertension, a condition associated with the cluster of metabolic syndrome is a medical condition associated with abnormally high blood pressure.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood and changes constantly depending on activity. However, persistent hypertension due to poor management over time can lead to diabetes and cardiovascular disease.

According to the statistics provided by the American Heart Association., nearly half of all adults in the United States are living with high blood pressure, or 1 in 3 Americans are hypertensive.

Hypertension is a leading risk factor of heart disease and stroke that cause most death in the US

The most common prevalent factors associated with the condition onset are family history, aging, being male, being overweight or obese, ethnicity, physical inactivity, unhealthy diet, and medical conditions such as chronic kidney disease.


Believe it or not, excessive alcohol drinking is also one of the major causes besides obesity in elevating the syndrome onset.

Depending on the levels of blood pressure, most people with mild hypertension are asymptomatic. However, unmanaged high blood pressure can induce complications of heart attack or stroke, heart failure, weakened and narrowed blood vessels, metabolic syndrome, and trouble with memory or understanding,

In severe cases, chronic hypertension can lead to dementia.

Conventionally, blood pressure medications have been found to prevent many deaths from heart disease and stroke over the past 30 years, however, long-term intake of such medications has caused many side effects such as damaging the kidney.

Some researchers suggested by making lifestyle changes, maintaining an ideal weight and diet with low salt, you could do just fine without the drugs.

Dr. Myung Hwa Yang wrote, "healthy eating, weight management, and appropriate physical activity are essential for the management of high blood pressure in adults since these lifestyle management have the potential to improve blood pressure control and even reduce the need for medication.23)"

"Our findings indicate that to achieve better rates of blood pressure control, the clinician should advise lifestyle modifications such as adequate physical activity and low salt intake, in addition to prescribing medication and monitoring the patient for hypertension control".

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.


Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.

In finding a potent ingredient that processes cardioprotection researchers examined the effects of onion on blood pressure in N(G)-nitro-L-arginine methyl ester (L-NAME) induced-hypertensive rats and stroke-prone spontaneously hypertensive rats (SHRSP).

The vivo study included male 6-weeks-old Sprague-Dawley rats induced-hypertensive to receive tap water containing L-NAME of a concentration of 50 mg/kg BW/day and dried onion at 5%.

Onion application showed significant anti-hypertensive activity on the L-NAME induced-hypertensive rats and the SHRSP by decreasing the thiobarbituric acid reactive substances (TBARS) associated with lipid peroxidation in blood plasma.

Furthermore, nitrate/nitrite (products of nitric oxide (NO)) involved in blood vessel relaxation excreted in urine and the NO synthase (NOS) associated with vascular tone activity in the kidneys in SHRSP were also increased by the onion injection.

Interestingly, the efficacy of onion that inhibits the onset of high blood pressure was not found similar to those in the L-NAME-induced hypertensive rats such as increasing the levels of NOS.


More precisely, onion promoted hypotension in L-NAME treated rats without inhibiting of NOS activity by L-NAME, and decreased nitrate/nitrite excretion in urine may be associated with only the promotion of antioxidant activity

Dr. Sakai Y, the lead scientist said, "The mechanism of the antihypertensive effect of onion probably involves the increased saving of NO by the antioxidative activity of onion in L-NAME induced-hypertensive rats".


Taken together, onion may be considered a remedy for the prevention and treatment of hypertension, pending the confirmation of the larger sample size and multicenter human study.

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antihypertensive effects of onion on NO synthase inhibitor-induced hypertensiverats and spontaneously hypertensive rats by Sakai Y1, Murakami T, Yamamoto Y. (PubMed)
(2) Effects of boiling on the antihypertensive and antioxidant activities of onion by Kawamoto E1, Sakai Y, Okamura Y, Yamamoto Y. (PubMed)
(3) The Effect of Lifestyle Changes on Blood Pressure Control among Hypertensive Patients by Myung Hwa Yang,1 Seo Young Kang,1 Jung Ah Lee,1 Young Sik Kim,1 Eun Ju Sung,2Ka-Young Lee,3 Jun-Su Kim,3 Han Jin Oh,4 Hee Chul Kang,5 and Sang Yeoup Lee. (PMC)

#Cucumber's #Cucurbitacin B (CuB) Protects Gut Microbiota by Suppressing LPS-Induced Production of Pro-Inflammatory Cytokines

Kyle J. Norton

Gut Microbiota is a community of microorganisms living in our gut. Under normal conditions, the ratio of the gut microbiome composition is balanced.

However, the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle may alternate the ratio by increasing the growth of "bad" bacteria, leading to the development of chronic diseases such as inflammatory bowel disease, obesity, cancer, and autism.

In other words, an imbalance of the gut microbiota may have a strong and negative impact on immunity, digestive, fat, and carbohydrate metabolism, and the central nervous system

* In immunity, the balance of the gut microbes is shown to stimulate the immune function against inflammatory immune disorders.

* In the digestive system, balanced gut microbes protect the gut against gastrointestinal diseases and non-gastrointestinal diseases. caused by overexpression of bad bacteria.

* In carbohydrate metabolism, gut microbes influence the nutrient extraction from the diet, thus reducing the risk of obesity and obesity complications.

* Neurologically, gut microbiota can control brain insulin signaling and metabolite levels that play a critical role in neurobehaviors.

Out of many prevalent factors that cause the onset of the unbalanced ratio of gut microbiota, some researchers suggested that the Western diet may have negatively influenced the overgrowth of bad microorganisms in the gut.

Dr. Marit K. Zinöcker, the lead scientist wrote, "Western diet promotes inflammation that arises from both structural and behavioral changes in the resident microbiome"

And, "The environment created in the gut by ultra-processed foods, a hallmark of the Western diet, is an evolutionarily unique selection ground for microbes that can promote diverse forms of inflammatory disease".


The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.

To find a natural compound that enhances the gut microbiome composition, researchers compared the effects of carrot, cucumber, and broccoli seed flour extracts with 50% acetone on gut microbiota modulating capacity.

In vitro, all three seed flour extracts enhanced the total number of gut bacteria and altered the abundance of specific bacterial phylum or genera.


In other words, cucumber showed a potential effect to improve the ratio of gut microbiota in the flavor of the "good" bacteria, similar to those of carrot and broccoli.


In J774A.1 cells, cucumber also exerted a similar activity by protecting the microbiota that exhibits anti-inflammatory activity by suppressing LPS-induced production of pro-inflammatory cytokines, such as IL-1β and COX-2 mRNA expressions.

Furthermore, in obesity-induced progression of metabolic disorders, especially type 2 diabetes (T2DM), cucumber not only improved IR in obese mice and relieved inflammation in adipose tissue and blood but also enhanced the microbiota composition ratios.


More precisely, cucumber improved the ratio of gut microbiome composition by promoting IR and reducing inflammation.

Taken together, cucumber may be used for the improvement of gut microbiota, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Chemical Compositions of Cold-Pressed Broccoli, Carrot, and Cucumber Seed Flours and Their in Vitro Gut Microbiota Modulatory, Anti-inflammatory, and Free Radical Scavenging Properties by Choe U1, Li Y1,2, Gao B2, Yu L1, Wang TTY, Sun J, Chen P, Liu J3, Yu L. (PubMed)
(2) Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the GutMicrobiome in Lepob/Lepob Mice by Lee D1, Yoo JH1, Lee BC. (PubMed)
(3) The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease by Marit K. Zinöcker1,* and Inge A. Lindseth. (PMC)