Kyle J. Norton
Chaste tree berry is found to be processability in reduced of MALE osteopenia turnover, the early sign of osteoporosis, a renowned institution study reported.
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.
Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period.
In a total of 60, 3-month-old male rats orchidectomized and divided into five groups with each group either receiving soy-free food (C), estradiol (E), testosterone (T) or Vitex agnus castus in different concentrations (AC high/AC low) for 12 weeks, rats treated with Vitex agnus castus at highest dose displayed a recover of 88.4% of trabecular bone area, 80.7% of trabecular number and 66.9% of the number of trabecular nodes compared with other administrations.
The study also found out that Vitex agnus castus is more protective in treating osteoporosis in the male population, compared to female counterparts.
Dr. Sehmisch S, the lead author said, " Vitex agnus castus demonstrated osteoprotective effects in males. It preserves the cortical as well as the trabecular bone and might be a safe alternative for HRT".
Furthermore, In the study to compare a group of animals (n = 8) treated subcutaneously (s.c.) with 60 mg/kg of Vac essential oil once a day for 3 weeks and control animals (n = 8) received sterile olive oil s.c. by the same schedule, Vitex agnus-castus L. (Vac) essential oil-treated group also exerted a significant bone metabolism in 16-month-old male Wistar rats.
The osteoporosis protection can be observed through the lower Serum osteocalcin (OC) and calcium (Ca2+) in Vitex agnus-castus L. (Vac) essential oil and decreased bone turnover treated group in compared control in middle-aged male rats.
Taken together, Chaste tree berry showed strong support in the reduced early onset of osteoporosis of male gander through improved bone metabolism and calcium status, but further large size and centers studies are necessary to validate this potency.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Sources
(1) Vitex agnus castus as prophylaxis for osteopenia after orchidectomy in rats compared with estradiol and testosterone supplementation by Sehmisch S1, Boeckhoff J, Wille J, Seidlova-Wuttke D, Rack T, Tezval M, Wuttke W, Stuermer KM, Stuermer EK. (PubMed)
(2) Vitex agnus-castus essential oil affects thyroid C cells and bone metabolism in middle-aged male rats (Researchgate)
Wednesday, 1 November 2023
#Herbal #CrampBark Increases the Rate of Stone Expulsion, According to Studies
Kyle J. Norton
The kidneys formed part of the secretary system are two bean-shaped organs located against the back muscles in the upper abdominal area.
The kidneys play a critical role in filtering wastes from the breakdown of active muscle and the food you eat and removing extra water from the blood through urinary secretion.
Furthermore, the kidneys also maintain the fluid in the body by secreting extra water through urinary secretion.
Kidney stones are composed of mineral salts formed in the kidneys. Men account for 80% kidney stones incidence and are at risk of forming between 30 and 40 years of age. About 75% of kidney stones are calcium stones.
According to statistics, kidney stones affect over 10% of the world's population.
The causes of kidney stones are debatable. However, some researchers suggested that dehydration, food restriction, Rotavirus infection, over intake of calcium and supplements,... and high fat intake are associated with an increased risk of forming kidney stones.
Ureteral stones are kidney stones that are stuck in one or both ureters (the tubes that carry urine from the kidneys to the bladder), leading to the obstruction of the urinary secretion.
Most people with kidney stones are asymptomatic. However, some may experience symptoms of renal colic, an excruciating intermittent pain, usually in the flank (the area between the ribs and hip), that spreads across the abdomen, often to the genital area and inner thigh.
The pain tends to come in waves, gradually increasing to peak intensity, then fading, over about 20 to 60 minutes. The pain may radiate down the abdomen toward the groin testis or vulva.
Other symptoms include nausea and vomiting, restlessness, sweating, and blood in the urine. A person may have an urge to urinate frequently, particularly as the stone passes down the ureter. Chills, fever, and abdominal distention.
Cramp Bark is an ornamental plant, genus Viburnum, belonging to the family Adoxaceae, native to Europe and Asia. T herbal medicine has been used in traditional and herbal medicine as anti-spasmodic, anti-inflammatory, nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with menopause, etc.
In finding a potential herbal medicine for the prevention and treatment of kidney stones, researchers examined the efficacy of Gilaburu (Viburnum opulus) extract in the treatment of distal ureteral stones <10 mm.
The study included data of a total of 103 patients retrospectively analyzed. divided into two groups: those given V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand (n=53) and those given only diclofenac sodium 50 mg peroral on-demand (n=50).
According to the expulsion rate assay, group treated with V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand showed a rate of stone expulsion that is significantly higher of 82% compared to the diclofenac 50 mg peroral on-demand treatment group of 66%.
Furthermore, elapsed time to stone expulsion was significantly shorter in the V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand of 9±1.8, compared to another group of 14±2.3 days.
Most importantly, the V. opulus group showed no need for additional treatment (URS and ESWL), and analgesic was less required compared to the other group.
Based on the findings, researchers said, "V. opulus is an herbal treatment alternative that facilitates the passage of ureteral stones <10 mm. Prospective, randomized studies are needed to support these results".
Taken together, cramp bark(Viburnum opulus) may be considered a functional remedy for the treatment of ureteral stones, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The evaluation of the effectiveness of Gilaburu (Viburnum opulus L.) extract in the medical expulsive treatment of distal ureteral stones by Kızılay F1, Ülker V2, Çelik O2, Özdemir T1, Çakmak Ö2, Can E2, Nazlı O. (PubMed)
The kidneys formed part of the secretary system are two bean-shaped organs located against the back muscles in the upper abdominal area.
The kidneys play a critical role in filtering wastes from the breakdown of active muscle and the food you eat and removing extra water from the blood through urinary secretion.
Furthermore, the kidneys also maintain the fluid in the body by secreting extra water through urinary secretion.
Kidney stones are composed of mineral salts formed in the kidneys. Men account for 80% kidney stones incidence and are at risk of forming between 30 and 40 years of age. About 75% of kidney stones are calcium stones.
According to statistics, kidney stones affect over 10% of the world's population.
The causes of kidney stones are debatable. However, some researchers suggested that dehydration, food restriction, Rotavirus infection, over intake of calcium and supplements,... and high fat intake are associated with an increased risk of forming kidney stones.
Ureteral stones are kidney stones that are stuck in one or both ureters (the tubes that carry urine from the kidneys to the bladder), leading to the obstruction of the urinary secretion.
Most people with kidney stones are asymptomatic. However, some may experience symptoms of renal colic, an excruciating intermittent pain, usually in the flank (the area between the ribs and hip), that spreads across the abdomen, often to the genital area and inner thigh.
The pain tends to come in waves, gradually increasing to peak intensity, then fading, over about 20 to 60 minutes. The pain may radiate down the abdomen toward the groin testis or vulva.
Other symptoms include nausea and vomiting, restlessness, sweating, and blood in the urine. A person may have an urge to urinate frequently, particularly as the stone passes down the ureter. Chills, fever, and abdominal distention.
Cramp Bark is an ornamental plant, genus Viburnum, belonging to the family Adoxaceae, native to Europe and Asia. T herbal medicine has been used in traditional and herbal medicine as anti-spasmodic, anti-inflammatory, nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with menopause, etc.
In finding a potential herbal medicine for the prevention and treatment of kidney stones, researchers examined the efficacy of Gilaburu (Viburnum opulus) extract in the treatment of distal ureteral stones <10 mm.
The study included data of a total of 103 patients retrospectively analyzed. divided into two groups: those given V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand (n=53) and those given only diclofenac sodium 50 mg peroral on-demand (n=50).
According to the expulsion rate assay, group treated with V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand showed a rate of stone expulsion that is significantly higher of 82% compared to the diclofenac 50 mg peroral on-demand treatment group of 66%.
Furthermore, elapsed time to stone expulsion was significantly shorter in the V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand of 9±1.8, compared to another group of 14±2.3 days.
Most importantly, the V. opulus group showed no need for additional treatment (URS and ESWL), and analgesic was less required compared to the other group.
Based on the findings, researchers said, "V. opulus is an herbal treatment alternative that facilitates the passage of ureteral stones <10 mm. Prospective, randomized studies are needed to support these results".
Taken together, cramp bark(Viburnum opulus) may be considered a functional remedy for the treatment of ureteral stones, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The evaluation of the effectiveness of Gilaburu (Viburnum opulus L.) extract in the medical expulsive treatment of distal ureteral stones by Kızılay F1, Ülker V2, Çelik O2, Özdemir T1, Çakmak Ö2, Can E2, Nazlı O. (PubMed)
#Herbal #Butterbur's Total Bakkenolides Reduce Brain Infarct Volume and Neurological Deficits, According to Studies
Kyle J. Norton
Herbal Butterbur may have a profound and strong effect on protecting the neuron integrity and validity against the onset of neuro diseases, some scientists suggested.
Neuroprotective effects are the activity that protects neurons of the brain and spinal cord.
A neurologic deficit is a condition of the brain, or spinal cord, leading to weaker muscles, nerves, or part of the body.
The causes of neurological deficit include genetic disorders, congenital abnormalities or disorders, infections, lifestyle or environmental health problems associated with malnutrition, and brain injury, spinal cord injury, or nerve injury.
People with a neurologic deficit may experience certain medical conditions and symptoms including partial or complete paralysis, loss of sensation, seizures, difficulty reading, writing and walking, and decreased alertness.
However, some researchers suggested the most serious symptoms are poor cognitive ability, depending on the parts of the brain or spinal cord which have been affected.
According to the statistic provided by the US government, more than 16 million people in the United States are living with cognitive impairment and disease with a tendency to increase at an alarming rate, particularly in the age group of 50 and over.
People with cognitive impairment, according to the report are more than three times as many hospital stays as individuals who are hospitalized for some other condition, causing a substantial burden to the US health care system.
Out of all neurodegenerative diseases, Alzheimer’s disease and related dementias alone are estimated to be the third most expensive disease to treat in the United States.
The Alzheimer’s Disease Facts and Figures 20106, wrote, “ The average Medicaid payment for a person aged 65 or older with Alzheimer’s or other dementias is nine times higher than that for other beneficiaries in the same age group.”
Butterbur, found in wet, marshy, damp land, including wetlands, riversides, forests, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to the Northern Hemisphere.
The herbal medicine has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.
The Second Military Medical University on finding a natural ingredient or whole food for the treatment of neurologic deficit examines the effect of the total bakkenolides, a bioactive compound isolated from the herbal Butterbur, in vitro cerebral ischemia model and oxygen-glucose deprivation of cultured nerve cells.
Oral administration of total bakkenolides showed a significant immediate effect after reperfusion at doses of 5, 10, and 20 mg/kg markedly reduced brain infarct volume and neurological deficits.
The chemical compound also was found to attenuate cell death and apoptosis in primary cultured neurons subject to 1-h hypoxia followed by 24-h reoxygenation.
The compound also protects the neurons by inhibiting the protein involved production of inflammatory cytokines through blocking the activation of the classical activation pathway due to the injury.
Further differentiation of the experiment, researchers discovered that total bakkenolides inhibit the activation of pathways associated with neuron apoptosis.
Dr. the lead scientists after taking into account of co and confounders said, "Our results provide a strong pharmacological basis for further understanding the potential therapeutic role of total bakkenolides in cerebral ischemic disease and shed new light on its neuroprotective mechanism".
Moreover, in the examine the neurologic deficit effects of 4 novel bakkenolides - bakkenolide-Ia ( 1), bakkenolide-IIa ( 2), bakkenolide-IIIa ( 3) and bakkenolide-IVa ( 4) isolated from the extract of the rhizome of Petasites tricholobus, researchers showed the compounds 1 - 4 exert a significantly neuroprotective activity in primary cultured neurons exposed to oxygen-glucose deprivation and oxidative insults by enhancing the antioxidant activity.
According to the VITRO assay, all these compounds exhibited significant neuroprotective and antioxidant activities.
The findings strongly suggested total bakkenolides and their derivatives demonstrate neurologic deficits protective effects through blocking the mechanisms involved in neuron cell apoptosis through their antioxidant property.
Taken together, herbal Butterbur processed bioactive compounds such as bakkenolides may be considered a functional herb for the prevention and combined with primary medicine for the treatment of neurologic deficits.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Total Bakkenolides Protects Neurons against Cerebral Ischemic Injury through Inhibition of Nuclear Factor-Κb Activation by Jiang Q, Xia Yy EY, Jm HE, Guo Ml EY, Rp LI. (PubMed)
(2) Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities by Wang YL, Li RP, Guo ML, Zhang G, Zhang N, Ma YL.(PubMed)
(3) Protection by petaslignolide A, a major neuroprotective compound in the butanol extract of Petasites japonicus leaves, against oxidative damage in the brains of mice challenged with kainic acid by Cui HS, Kim MR, Sok DE. (PubMed)
Herbal Butterbur may have a profound and strong effect on protecting the neuron integrity and validity against the onset of neuro diseases, some scientists suggested.
Neuroprotective effects are the activity that protects neurons of the brain and spinal cord.
A neurologic deficit is a condition of the brain, or spinal cord, leading to weaker muscles, nerves, or part of the body.
The causes of neurological deficit include genetic disorders, congenital abnormalities or disorders, infections, lifestyle or environmental health problems associated with malnutrition, and brain injury, spinal cord injury, or nerve injury.
People with a neurologic deficit may experience certain medical conditions and symptoms including partial or complete paralysis, loss of sensation, seizures, difficulty reading, writing and walking, and decreased alertness.
However, some researchers suggested the most serious symptoms are poor cognitive ability, depending on the parts of the brain or spinal cord which have been affected.
According to the statistic provided by the US government, more than 16 million people in the United States are living with cognitive impairment and disease with a tendency to increase at an alarming rate, particularly in the age group of 50 and over.
People with cognitive impairment, according to the report are more than three times as many hospital stays as individuals who are hospitalized for some other condition, causing a substantial burden to the US health care system.
Out of all neurodegenerative diseases, Alzheimer’s disease and related dementias alone are estimated to be the third most expensive disease to treat in the United States.
The Alzheimer’s Disease Facts and Figures 20106, wrote, “ The average Medicaid payment for a person aged 65 or older with Alzheimer’s or other dementias is nine times higher than that for other beneficiaries in the same age group.”
Butterbur, found in wet, marshy, damp land, including wetlands, riversides, forests, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to the Northern Hemisphere.
The herbal medicine has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.
The Second Military Medical University on finding a natural ingredient or whole food for the treatment of neurologic deficit examines the effect of the total bakkenolides, a bioactive compound isolated from the herbal Butterbur, in vitro cerebral ischemia model and oxygen-glucose deprivation of cultured nerve cells.
Oral administration of total bakkenolides showed a significant immediate effect after reperfusion at doses of 5, 10, and 20 mg/kg markedly reduced brain infarct volume and neurological deficits.
The chemical compound also was found to attenuate cell death and apoptosis in primary cultured neurons subject to 1-h hypoxia followed by 24-h reoxygenation.
The compound also protects the neurons by inhibiting the protein involved production of inflammatory cytokines through blocking the activation of the classical activation pathway due to the injury.
Further differentiation of the experiment, researchers discovered that total bakkenolides inhibit the activation of pathways associated with neuron apoptosis.
Dr. the lead scientists after taking into account of co and confounders said, "Our results provide a strong pharmacological basis for further understanding the potential therapeutic role of total bakkenolides in cerebral ischemic disease and shed new light on its neuroprotective mechanism".
Moreover, in the examine the neurologic deficit effects of 4 novel bakkenolides - bakkenolide-Ia ( 1), bakkenolide-IIa ( 2), bakkenolide-IIIa ( 3) and bakkenolide-IVa ( 4) isolated from the extract of the rhizome of Petasites tricholobus, researchers showed the compounds 1 - 4 exert a significantly neuroprotective activity in primary cultured neurons exposed to oxygen-glucose deprivation and oxidative insults by enhancing the antioxidant activity.
According to the VITRO assay, all these compounds exhibited significant neuroprotective and antioxidant activities.
The findings strongly suggested total bakkenolides and their derivatives demonstrate neurologic deficits protective effects through blocking the mechanisms involved in neuron cell apoptosis through their antioxidant property.
Taken together, herbal Butterbur processed bioactive compounds such as bakkenolides may be considered a functional herb for the prevention and combined with primary medicine for the treatment of neurologic deficits.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Total Bakkenolides Protects Neurons against Cerebral Ischemic Injury through Inhibition of Nuclear Factor-Κb Activation by Jiang Q, Xia Yy EY, Jm HE, Guo Ml EY, Rp LI. (PubMed)
(2) Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities by Wang YL, Li RP, Guo ML, Zhang G, Zhang N, Ma YL.(PubMed)
(3) Protection by petaslignolide A, a major neuroprotective compound in the butanol extract of Petasites japonicus leaves, against oxidative damage in the brains of mice challenged with kainic acid by Cui HS, Kim MR, Sok DE. (PubMed)
#Herbal #Comfrey Inhibits Symptoms of Painful Osteoarthritis of the Knee, Researchers Say
Kyle J. Norton
Osteoarthritis (OA) one of the most common forms of arthritis that affects over 25 25 million people in the United States, is a chronic inflammatory disease of the joints due to wear and tear over time.
The characteristics of osteoarthritis are aching pain, stiffness, or difficulty in moving the joint or joints. The pain usually gets worse in a change of weather, at night, and in advanced diseases, the pain can occur even at rest.
Conventionally, treatment of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments.
The most common risk factors associated with the onset of OA include genetic predisposition, being overweight or obese, previous joint injury and repetitive movements, or injuries to joints (such as a fracture, surgery, or ligament tears).
the most common diseases associated with OA are
* Hypertension
According to the University Health Network Research Institute, the economic burden incurred by RA significantly exceeds that related to OA and HBP(76)(77).
* Cardiovascular disease
According to Erasmus University Medical Centre, there are associations of atherosclerosis with osteoarthritis of the knee and hand joints in women(72)(73)(78).
* Peripheral vascular disease
According to Himchan Hospital, patients with osteoarthritis are associated with a risk of asymptomatic peripheral vascular disease(80). The average vessel wall thickness of the popliteal artery was 1.09 mm in patients with generalized OA, and 0.96 mm in the matched normal reference population(79).
* Congestive heart failure
Hypertension, diabetes, and older age have been shown to increase the risk of Congestive heart failure modestly(81). Etoricoxib, an anti-inflammatory painkillers showed statistically significant inhibition at 90 mg in patients with osteoarthritis and rheumatoid arthritis(82).
* Renal function impairment
According to the Southampton University Hospitals NHS Trust, pain pharmacotherapies such as osteoarthritis (OA) or mixed OA and rheumatoid arthritis may increase the risk of adverse events in patients with concurrent cardiovascular (CV) or renal disease(83). Median excretion of pyridinoline and deoxypyridinoline in the OA patients as a whole was raised above values found in a healthy control population(84).
* Diabetes
Several epidemiological and experimental data support the hypothesis that diabetes could be an independent risk factor for osteoarthritis (OA)(76)(85).
Comfrey is a perennial plant in the genus of Symphytum, belonging to the family Boraginaceae, native to Europe. It has been used in herbal and traditional medicine to ease excessive bleeding or on open wounds, relieve pain and swelling, treat circulation issues, reduce cholesterol, etc.
In finding a potential compound for the treatment of osteoarthritis, researchers investigated the effect of Kytta-Salbe f (3 x 2 g), a topical including comfrey over a 3-week period with patients suffering from painful osteoarthritis of the knee.
The randomized, double-blind, bi-center, placebo-controlled clinical trial including 220 patients was conducted by Merck Selbstmedikation GmbH.
In the course of the trial, the visual analog scale (VAS) total score (primary target value) in the verum group dropped by 51.6 mm (54.7%) and in the placebo group by 10.1 mm (10.7%).
The average difference between the groups of 41.5 mm (95% confidence interval=34.8 to 48.2 mm) or 44.0% is significant (p<0.001).
The WOMAC (Western Ontario and McMaster Universities) total score (secondary target value) also improved similarly to the VAS total score.
At the end of the trial, a reduction of 60.4 mm (58.0%) was recorded for the verum group and a reduction of 14.7 mm (14.1%) for the placebo group.
The average group difference of 45.7 mm (95% confidence interval=37.1 to 54.3 mm) or 43.9% is significant (p<0.001).
The difference between the treatment groups increased systematically and significantly, in parallel with the duration of the treatment.
Based on the results, researchers said, "the superiority of the treatment with Kytta-Salbe f over that with the placebo is proven, even through the multi-factorial multivariate analysis for repetitive measurements. In respect of the explorative secondary target values SF-36 (quality of life), angle measurement (mobility of the knee), CGI (clinical global impression), and global assessment of efficacy by the physician and the patient, a significant superiority (p<0.001 each) of the verum group over the placebo group was also proven".
Taken together, Comfrey combined with other herbal medicines may be considered for the treatment of a remedy for painful osteoarthritis, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy of a comfrey root (Symphyti offic. radix) extract ointment in the treatment of patients with painful osteoarthritis of the knee: results of a double-blind, randomised, bicenter, placebo-controlled trial by Grube B1, Grünwald J, Krug L, Staiger C. (PubMed)
(2) The Research and Studies of Musculo-Skeletal disorders(MSDs) - Osteoarthritis: The Diseases associated with osteoarthritis by Kyle J. Norton
Osteoarthritis (OA) one of the most common forms of arthritis that affects over 25 25 million people in the United States, is a chronic inflammatory disease of the joints due to wear and tear over time.
The characteristics of osteoarthritis are aching pain, stiffness, or difficulty in moving the joint or joints. The pain usually gets worse in a change of weather, at night, and in advanced diseases, the pain can occur even at rest.
Conventionally, treatment of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments.
The most common risk factors associated with the onset of OA include genetic predisposition, being overweight or obese, previous joint injury and repetitive movements, or injuries to joints (such as a fracture, surgery, or ligament tears).
the most common diseases associated with OA are
* Hypertension
According to the University Health Network Research Institute, the economic burden incurred by RA significantly exceeds that related to OA and HBP(76)(77).
* Cardiovascular disease
According to Erasmus University Medical Centre, there are associations of atherosclerosis with osteoarthritis of the knee and hand joints in women(72)(73)(78).
* Peripheral vascular disease
According to Himchan Hospital, patients with osteoarthritis are associated with a risk of asymptomatic peripheral vascular disease(80). The average vessel wall thickness of the popliteal artery was 1.09 mm in patients with generalized OA, and 0.96 mm in the matched normal reference population(79).
* Congestive heart failure
Hypertension, diabetes, and older age have been shown to increase the risk of Congestive heart failure modestly(81). Etoricoxib, an anti-inflammatory painkillers showed statistically significant inhibition at 90 mg in patients with osteoarthritis and rheumatoid arthritis(82).
* Renal function impairment
According to the Southampton University Hospitals NHS Trust, pain pharmacotherapies such as osteoarthritis (OA) or mixed OA and rheumatoid arthritis may increase the risk of adverse events in patients with concurrent cardiovascular (CV) or renal disease(83). Median excretion of pyridinoline and deoxypyridinoline in the OA patients as a whole was raised above values found in a healthy control population(84).
* Diabetes
Several epidemiological and experimental data support the hypothesis that diabetes could be an independent risk factor for osteoarthritis (OA)(76)(85).
Comfrey is a perennial plant in the genus of Symphytum, belonging to the family Boraginaceae, native to Europe. It has been used in herbal and traditional medicine to ease excessive bleeding or on open wounds, relieve pain and swelling, treat circulation issues, reduce cholesterol, etc.
In finding a potential compound for the treatment of osteoarthritis, researchers investigated the effect of Kytta-Salbe f (3 x 2 g), a topical including comfrey over a 3-week period with patients suffering from painful osteoarthritis of the knee.
The randomized, double-blind, bi-center, placebo-controlled clinical trial including 220 patients was conducted by Merck Selbstmedikation GmbH.
In the course of the trial, the visual analog scale (VAS) total score (primary target value) in the verum group dropped by 51.6 mm (54.7%) and in the placebo group by 10.1 mm (10.7%).
The average difference between the groups of 41.5 mm (95% confidence interval=34.8 to 48.2 mm) or 44.0% is significant (p<0.001).
The WOMAC (Western Ontario and McMaster Universities) total score (secondary target value) also improved similarly to the VAS total score.
At the end of the trial, a reduction of 60.4 mm (58.0%) was recorded for the verum group and a reduction of 14.7 mm (14.1%) for the placebo group.
The average group difference of 45.7 mm (95% confidence interval=37.1 to 54.3 mm) or 43.9% is significant (p<0.001).
The difference between the treatment groups increased systematically and significantly, in parallel with the duration of the treatment.
Based on the results, researchers said, "the superiority of the treatment with Kytta-Salbe f over that with the placebo is proven, even through the multi-factorial multivariate analysis for repetitive measurements. In respect of the explorative secondary target values SF-36 (quality of life), angle measurement (mobility of the knee), CGI (clinical global impression), and global assessment of efficacy by the physician and the patient, a significant superiority (p<0.001 each) of the verum group over the placebo group was also proven".
Taken together, Comfrey combined with other herbal medicines may be considered for the treatment of a remedy for painful osteoarthritis, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy of a comfrey root (Symphyti offic. radix) extract ointment in the treatment of patients with painful osteoarthritis of the knee: results of a double-blind, randomised, bicenter, placebo-controlled trial by Grube B1, Grünwald J, Krug L, Staiger C. (PubMed)
(2) The Research and Studies of Musculo-Skeletal disorders(MSDs) - Osteoarthritis: The Diseases associated with osteoarthritis by Kyle J. Norton
Tuesday, 31 October 2023
3,3'-#Diindolylmethane Inhibits Enzymes, Proteins and Expressions Associated with the Proliferation of #ProstateCancer, According to Researchers
Kyle J. Norton
Scientists may have found a plan based bioactive compound for the treatment of prostate cancer with no side effects, according to studies.
Prostate cancer is a medical condition caused by cell growth disorderly in the tissue of the prostate glands. Prostate cancer is one of the most slow-growing cancers that take years to develop.
The disease often is discovered during the rectum examine annually. Most cases of prostate cancer start in the cells on the surface of the inner lining of prostate tissue.
In the early stage, patients may not experience any symptoms. However, at the advanced stage, prostate cancer can induce symptoms of blood in the urine and semen, disruption of urinary passing, frequent and urged urinary.
In severe cases, prostate cancer can also cause erectile dysfunction.
According to statistics, 1 man in 9 will be diagnosed with prostate cancer during his lifetime.
Most cases ( about 60%) of prostate cancer are found in older men, particularly in the African-American. The 5-year survival rate of local or regional prostate cancer is nearly 100.
Out of many risk factors, the unhealthy diet may be one of the major risk factors associated with the onset of the disease.
Some researchers in the study of the preventive diet against prostate cancer wrote, " Although the available data are not entirely consistent, possible preventative behavioral factors include increased physical activity, intakes of tomatoes, cruciferous vegetables, and soy. Factors that may enhance prostate cancer risk include frequent consumption of dairy products and, possibly, meat".
" By comparison, alcohol probably exerts no important influence on prostate cancer development. Similarly, dietary supplements are unlikely to protect against the onset of prostate cancer in healthy men".
"Several factors, such as smoking and obesity, show a weak association with prostate cancer incidence but a positive relation with prostate cancer mortality. Other factors, such as fish intake, also appear to be unassociated with incident prostate cancer but show an inverse relation with fatal prostate cancer".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding a natural compound for the treatment of prostate cancer examined the effect of 3,3'-Diindolylmethane (DIM) as tumor inhibitors in multiple malignant tumors on microRNAs (miRNAs).
Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) application showed a significant effect in the inhibition of proliferation and invasion of prostate cancer cells.
Furthermore, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment induced cancer death by inhibiting the expression level of CYP1A1, an enzyme associated with the activation of the compounds with carcinogenic properties.
In other words, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment activated the expression of MAP3K12 in the promotion of cancer cells by targeting the mRNA of miR-150-5p in prostate cancer cells.
Moreover, in order to reveal more information about DIM anti-prostate cancer activity, researchers examine the modulation of the immune system by cancer-protective food bioactives, indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM).
Injection of indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), exerted prostate cell protective effect by the regulation of inflammatory responses in monocytes and macrophages of the immune system.
In other words, I3C and DIM inhibited the lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria in the induction of IL-1β mRNA associated with the immune response to infection and protein in the monocyte form of the white blood cells.
I3C and DIM also exerted anti-inflammatory activity by inhibiting the expression of gene CD84 mRNA in signaling T-cell activation by regulating the proteins associated with the expression of the gene.
Dr. Wang TTY and colleagues after taking into account co and confounders, wrote, "cross-talk between AHR(protein associated with regulating gene expression) and inflammation-mediated pathways, but not CD84-mediated pathways, in monocytes but not macrophages may contribute to the modulation of tumor environments by I3C and DIM in prostate cancer'.
The results strongly suggested that DIM modulated the immune function against the process of prostate cancer development and progression.
Taken together, DIM may be considered a supplement for the prevention and combined with primary medicine for the treatment of prostate cancer, pending to the confirmation of larger sample size and multicenter human study.
Intake of DIM in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12 by Yu J1, Feng Y1, Wang Y1, An R. (PubMed)
(2) Elucidating the Role of CD84 and AHR in Modulation of LPS-Induced Cytokines Production by Cruciferous Vegetable-Derived Compounds Indole-3-Carbinol and 3,3'-Diindolylmethane by Wang TTY1, Pham Q2, Kim YS. (PubMed)
(3) Risk factors for the onset of prostatic cancer: age, location, and behavioral correlates by Michael F Leitzmann1 and Sabine Rohrmann. (PMC)
Scientists may have found a plan based bioactive compound for the treatment of prostate cancer with no side effects, according to studies.
Prostate cancer is a medical condition caused by cell growth disorderly in the tissue of the prostate glands. Prostate cancer is one of the most slow-growing cancers that take years to develop.
The disease often is discovered during the rectum examine annually. Most cases of prostate cancer start in the cells on the surface of the inner lining of prostate tissue.
In the early stage, patients may not experience any symptoms. However, at the advanced stage, prostate cancer can induce symptoms of blood in the urine and semen, disruption of urinary passing, frequent and urged urinary.
In severe cases, prostate cancer can also cause erectile dysfunction.
According to statistics, 1 man in 9 will be diagnosed with prostate cancer during his lifetime.
Most cases ( about 60%) of prostate cancer are found in older men, particularly in the African-American. The 5-year survival rate of local or regional prostate cancer is nearly 100.
Out of many risk factors, the unhealthy diet may be one of the major risk factors associated with the onset of the disease.
Some researchers in the study of the preventive diet against prostate cancer wrote, " Although the available data are not entirely consistent, possible preventative behavioral factors include increased physical activity, intakes of tomatoes, cruciferous vegetables, and soy. Factors that may enhance prostate cancer risk include frequent consumption of dairy products and, possibly, meat".
" By comparison, alcohol probably exerts no important influence on prostate cancer development. Similarly, dietary supplements are unlikely to protect against the onset of prostate cancer in healthy men".
"Several factors, such as smoking and obesity, show a weak association with prostate cancer incidence but a positive relation with prostate cancer mortality. Other factors, such as fish intake, also appear to be unassociated with incident prostate cancer but show an inverse relation with fatal prostate cancer".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding a natural compound for the treatment of prostate cancer examined the effect of 3,3'-Diindolylmethane (DIM) as tumor inhibitors in multiple malignant tumors on microRNAs (miRNAs).
Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) application showed a significant effect in the inhibition of proliferation and invasion of prostate cancer cells.
Furthermore, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment induced cancer death by inhibiting the expression level of CYP1A1, an enzyme associated with the activation of the compounds with carcinogenic properties.
In other words, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment activated the expression of MAP3K12 in the promotion of cancer cells by targeting the mRNA of miR-150-5p in prostate cancer cells.
Moreover, in order to reveal more information about DIM anti-prostate cancer activity, researchers examine the modulation of the immune system by cancer-protective food bioactives, indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM).
Injection of indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), exerted prostate cell protective effect by the regulation of inflammatory responses in monocytes and macrophages of the immune system.
In other words, I3C and DIM inhibited the lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria in the induction of IL-1β mRNA associated with the immune response to infection and protein in the monocyte form of the white blood cells.
I3C and DIM also exerted anti-inflammatory activity by inhibiting the expression of gene CD84 mRNA in signaling T-cell activation by regulating the proteins associated with the expression of the gene.
Dr. Wang TTY and colleagues after taking into account co and confounders, wrote, "cross-talk between AHR(protein associated with regulating gene expression) and inflammation-mediated pathways, but not CD84-mediated pathways, in monocytes but not macrophages may contribute to the modulation of tumor environments by I3C and DIM in prostate cancer'.
The results strongly suggested that DIM modulated the immune function against the process of prostate cancer development and progression.
Taken together, DIM may be considered a supplement for the prevention and combined with primary medicine for the treatment of prostate cancer, pending to the confirmation of larger sample size and multicenter human study.
Intake of DIM in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12 by Yu J1, Feng Y1, Wang Y1, An R. (PubMed)
(2) Elucidating the Role of CD84 and AHR in Modulation of LPS-Induced Cytokines Production by Cruciferous Vegetable-Derived Compounds Indole-3-Carbinol and 3,3'-Diindolylmethane by Wang TTY1, Pham Q2, Kim YS. (PubMed)
(3) Risk factors for the onset of prostatic cancer: age, location, and behavioral correlates by Michael F Leitzmann1 and Sabine Rohrmann. (PMC)
#Ashwagandha Extracts and Its #Principles #Exert Underlying Molecular Mechanism(s) in the inhibition of Brain Pathologies, Researchers Show
Kyle J. Norton
The central system is the complex of nerve tissues including the brain and spinal cord with functions to respond to the integrating sensory information.
Neuroinflammation is a process of the immune system's response to harmful pathogens that induce oxidative stress in the brain.
Neuroinflammation is also the inflammation of nervous tissue associated with the immune response in the first phase of infection including infection, traumatic brain injury, toxic metabolites, or autoimmunity.
Neurological disorders are a class of diseases associated with the brain, and the spinal cord including the nerves that connect them.
The most common disease of neurological disorders is dementia, including ALS. PD, Alzheimer's disease, birth defects of the brain and spinal cord, brain injury and tumor.
Back pain associated with related nerve damage is one of the common complaints in the US that send many patients to seek help from their doctor. Believe it or not, 80% of the US population will experience back pain at some time in their lives.
There is no single cause of neuro-dysfunction. Lifestyle, infections, genetics, and nutrition-related disease, environment, and physical injuries have been found to some major prevalent factors that induce the onset of neurological abnormalities.
Furthermore, neurological disorders have been found to facilitate psychological symptoms such as anxiety and depression and physical symptoms, depending totally on the neurons affected, including partial or complete paralysis muscle weakness seen in post-stroke patients, difficulty reading and writing, and poor cognitive abilities such as patients with dementia.
According to the American Addiction Center, if you experience some of the below symptoms persistently, inclduing headaches, blurry vision, persistent fatigue, changes in behavior, numbness in the legs or arms, changes in coordination or balance weakness, slurred speech and tremors, you should seek help from the professionals immediately, as these may be the first signs of neurological disorders.
Neurodegenerative diseases are the most common forms of low-grade chronic neuroinflammation, including Alzheimer's disease, vascular dementia, and dementia with Lewy bodies.
Dr. WEI-WEI CHEN, the lead scientist at the Xuzhou Central Hospital in the investigation of inflammatory cytokines and chronic neuroinflammation wrote, "Accordingly, pro-inflammatory cytokines are important in the pathophysiology of depression and dementia"
And, "These data suggest that the role of neuroinflammation in neurodegeneration must be fully elucidated, since pro-inflammatory agents, which are the causative effects of neuroinflammation, occur widely, particularly in the elderly in whom inflammatory mechanisms are linked to the pathogenesis of functional and mental impairments.".
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In finding a potent compound for enhancing brain performance, researchers examined the ashwagandha effects on the neurons.
Epidemiologically, environmental stressors have been found to cause global concerns in modern society, by rapidly increasing the incidence of a variety of pathological conditions including brain tumors, and neurodegenerative & neuropsychiatric disorders.
Ashwagandha used in Indian traditional home medicine has been shown to process the anti-stress and remedial potential for the treatment of aging and neurodegenerative pathologies, including environmental toxins.
Furthermore, Ashwagandha extracts and their active principles also exerted the underlying molecular mechanism(s) that inhibits the brain pathologies through the herb nootropic potency.
Moreover, in the examing the Ashwagandha leaf extracts effects, researchers found that the Ashwagandha inhibited neuroblastoma and glioma cell initiation, and reversal of Alzheimer's and Parkinson's pathologies, protection against environmental neurotoxins and enhancement of memory.
Based on the findings, researchers said, "Ashwagandha supplementation is associated with significant increases in muscle mass and strength and suggests that ashwagandha supplementation may be useful in conjunction with a resistance training program".
Taken altogether, Ashwagandha may be considered a functional herb that increases body mass and strength in resistance training, pending the result of a larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Nootropic potential of Ashwagandha leaves: Beyond traditional root extracts by Wadhwa R1, Konar A1, Kaul SC. (PubMed)
(2) Role of neuroinflammation in neurodegenerative diseases (Review) by Chen WW1, Zhang X1, Huang WJ. (PubMed)
The central system is the complex of nerve tissues including the brain and spinal cord with functions to respond to the integrating sensory information.
Neuroinflammation is a process of the immune system's response to harmful pathogens that induce oxidative stress in the brain.
Neuroinflammation is also the inflammation of nervous tissue associated with the immune response in the first phase of infection including infection, traumatic brain injury, toxic metabolites, or autoimmunity.
Neurological disorders are a class of diseases associated with the brain, and the spinal cord including the nerves that connect them.
The most common disease of neurological disorders is dementia, including ALS. PD, Alzheimer's disease, birth defects of the brain and spinal cord, brain injury and tumor.
Back pain associated with related nerve damage is one of the common complaints in the US that send many patients to seek help from their doctor. Believe it or not, 80% of the US population will experience back pain at some time in their lives.
There is no single cause of neuro-dysfunction. Lifestyle, infections, genetics, and nutrition-related disease, environment, and physical injuries have been found to some major prevalent factors that induce the onset of neurological abnormalities.
Furthermore, neurological disorders have been found to facilitate psychological symptoms such as anxiety and depression and physical symptoms, depending totally on the neurons affected, including partial or complete paralysis muscle weakness seen in post-stroke patients, difficulty reading and writing, and poor cognitive abilities such as patients with dementia.
According to the American Addiction Center, if you experience some of the below symptoms persistently, inclduing headaches, blurry vision, persistent fatigue, changes in behavior, numbness in the legs or arms, changes in coordination or balance weakness, slurred speech and tremors, you should seek help from the professionals immediately, as these may be the first signs of neurological disorders.
Neurodegenerative diseases are the most common forms of low-grade chronic neuroinflammation, including Alzheimer's disease, vascular dementia, and dementia with Lewy bodies.
Dr. WEI-WEI CHEN, the lead scientist at the Xuzhou Central Hospital in the investigation of inflammatory cytokines and chronic neuroinflammation wrote, "Accordingly, pro-inflammatory cytokines are important in the pathophysiology of depression and dementia"
And, "These data suggest that the role of neuroinflammation in neurodegeneration must be fully elucidated, since pro-inflammatory agents, which are the causative effects of neuroinflammation, occur widely, particularly in the elderly in whom inflammatory mechanisms are linked to the pathogenesis of functional and mental impairments.".
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In finding a potent compound for enhancing brain performance, researchers examined the ashwagandha effects on the neurons.
Epidemiologically, environmental stressors have been found to cause global concerns in modern society, by rapidly increasing the incidence of a variety of pathological conditions including brain tumors, and neurodegenerative & neuropsychiatric disorders.
Ashwagandha used in Indian traditional home medicine has been shown to process the anti-stress and remedial potential for the treatment of aging and neurodegenerative pathologies, including environmental toxins.
Furthermore, Ashwagandha extracts and their active principles also exerted the underlying molecular mechanism(s) that inhibits the brain pathologies through the herb nootropic potency.
Moreover, in the examing the Ashwagandha leaf extracts effects, researchers found that the Ashwagandha inhibited neuroblastoma and glioma cell initiation, and reversal of Alzheimer's and Parkinson's pathologies, protection against environmental neurotoxins and enhancement of memory.
Based on the findings, researchers said, "Ashwagandha supplementation is associated with significant increases in muscle mass and strength and suggests that ashwagandha supplementation may be useful in conjunction with a resistance training program".
Taken altogether, Ashwagandha may be considered a functional herb that increases body mass and strength in resistance training, pending the result of a larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Nootropic potential of Ashwagandha leaves: Beyond traditional root extracts by Wadhwa R1, Konar A1, Kaul SC. (PubMed)
(2) Role of neuroinflammation in neurodegenerative diseases (Review) by Chen WW1, Zhang X1, Huang WJ. (PubMed)
#Herbal #Turmeric Inhibits Proteins, TNF-Alpha Levels and Mean Clinical and Histopathological Grade Associated with the Onset of #Uveitis, According to Studies
Kyle J. Norton
Uveitis is a type of eye inflammation, affecting the middle layer of tissue in the eye wall (uvea).
The condition has been found to onset suddenly and get worse quickly. The most common symptoms of uveitis are eye redness, pain, and blurred vision that can affect one or both eyes.
In some cases, patients with the condition also experience symptoms of light sensitivity, floaters, and decreased vision.
If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
The exact cause of uveitis is unknown. However, some researchers suggested that people with a compromised immune system associated with inflammatory disease and infected diseases are at an increased risk of uveitis.
Other risk factors, epidemiologically such as eye injury, and diseases that affect the eye such as diabetes are also found in patients with uveitis.
Most cases of uveitis are treated by prescription eye drops in combination with anti-inflammatory medications. If all fail, surgery may be necessary.
Untreated uveitis has been found to induce complications of glaucoma, cataracts, optic nerve damage and retinal detachment.
Out of the prevalent factors of uveitis, some researchers suggested that aging associated with the weakened immune system may be the major factor that causes uveitis.
Dr, Marwan R. Abdulaal, the lead scientist said, "Uveitis is a vision-threatening inflammation of the eye that carries considerable morbidity. It is responsible for 10% of legal blindness in the United States and up to 25% in the developing world".
And. "The aging body has a changing response of the immune system, which might reflect a different pattern of uveitis in the elderly population".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of uveitis, researchers examined the effect on turmeric administered 4 h after induction of E. coli lipopolysaccharide-induced uveitis in rats.
Compared to the control group, turmeric showed significantly suppressed inflammation with a significantly lower mean clinical grade, histopathological grade, and aqueous humor (AH) protein level, second to the conventional medicine prednisolone.
The turmeric administered 4 h did not affect proinflammatory cytokines levels of TNF-alpha levels.
However, when the aqueous extract was administered starting 3 days before induction of uveitis, the treatment group not only showed a similar effect on the mean clinical and histopathological grade, as well as AH protein but also reduced TNF-alpha levels, comparable to the treatment group.
Based on the findings, researchers said, "topically applied a standardized aqueous extract of C. longa suppresses endotoxin-induced uveitis in rats by reducing TNF-alpha activity".
To reveal more information about turmeric's anti-uveitis properties, researchers examined the anterior uveitis induced in rabbits by intravitreal injection of lipopolysaccharide from Escherichia coli after pretreatment with C. longa and B. aristata aqueous extracts.
According to the clinical and histopathologic grading, anterior segment inflammation in the control group was significantly higher compared to both the extract-treated groups.
More precisely, the inflammatory cell count in the control group was 30.75 cells/mL compared to 2.39 and 11.56 cells/mL in the C. longa- and B. aristata-treated groups, respectively.
Similarly, C. longa- and B. aristata-treated groups also exerted strong effects on the protein content and TNF-alpha level as of that in the aforementioned study.
Taken together, turmeric may be considered a supplement for the prevention and treatment of uveitis, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Topically applied standardized aqueous extract of Curcuma longa Linn. suppresses endotoxin-induced uveal inflammation in rats by Agarwal R1, Gupta SK, Agarwal P, Srivastava S. (PubMed)
(2) The anti-inflammatory effects of Curcuma longa and Berberis aristata in endotoxin-induced uveitis in rabbits by Gupta SK1, Agarwal R, Srivastava S, Agarwal P, Agrawal SS, Saxena R, Galpalli N. (PubMed)
(3) Uveitis in the Aging Eye: Incidence, Patterns, and Differential Diagnosis by Marwan R. Abdulaal, Bachir H. Abiad, and Rola N. Hamam. (PMC)
Uveitis is a type of eye inflammation, affecting the middle layer of tissue in the eye wall (uvea).
The condition has been found to onset suddenly and get worse quickly. The most common symptoms of uveitis are eye redness, pain, and blurred vision that can affect one or both eyes.
In some cases, patients with the condition also experience symptoms of light sensitivity, floaters, and decreased vision.
If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
The exact cause of uveitis is unknown. However, some researchers suggested that people with a compromised immune system associated with inflammatory disease and infected diseases are at an increased risk of uveitis.
Other risk factors, epidemiologically such as eye injury, and diseases that affect the eye such as diabetes are also found in patients with uveitis.
Most cases of uveitis are treated by prescription eye drops in combination with anti-inflammatory medications. If all fail, surgery may be necessary.
Untreated uveitis has been found to induce complications of glaucoma, cataracts, optic nerve damage and retinal detachment.
Out of the prevalent factors of uveitis, some researchers suggested that aging associated with the weakened immune system may be the major factor that causes uveitis.
Dr, Marwan R. Abdulaal, the lead scientist said, "Uveitis is a vision-threatening inflammation of the eye that carries considerable morbidity. It is responsible for 10% of legal blindness in the United States and up to 25% in the developing world".
And. "The aging body has a changing response of the immune system, which might reflect a different pattern of uveitis in the elderly population".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of uveitis, researchers examined the effect on turmeric administered 4 h after induction of E. coli lipopolysaccharide-induced uveitis in rats.
Compared to the control group, turmeric showed significantly suppressed inflammation with a significantly lower mean clinical grade, histopathological grade, and aqueous humor (AH) protein level, second to the conventional medicine prednisolone.
The turmeric administered 4 h did not affect proinflammatory cytokines levels of TNF-alpha levels.
However, when the aqueous extract was administered starting 3 days before induction of uveitis, the treatment group not only showed a similar effect on the mean clinical and histopathological grade, as well as AH protein but also reduced TNF-alpha levels, comparable to the treatment group.
Based on the findings, researchers said, "topically applied a standardized aqueous extract of C. longa suppresses endotoxin-induced uveitis in rats by reducing TNF-alpha activity".
To reveal more information about turmeric's anti-uveitis properties, researchers examined the anterior uveitis induced in rabbits by intravitreal injection of lipopolysaccharide from Escherichia coli after pretreatment with C. longa and B. aristata aqueous extracts.
According to the clinical and histopathologic grading, anterior segment inflammation in the control group was significantly higher compared to both the extract-treated groups.
More precisely, the inflammatory cell count in the control group was 30.75 cells/mL compared to 2.39 and 11.56 cells/mL in the C. longa- and B. aristata-treated groups, respectively.
Similarly, C. longa- and B. aristata-treated groups also exerted strong effects on the protein content and TNF-alpha level as of that in the aforementioned study.
Taken together, turmeric may be considered a supplement for the prevention and treatment of uveitis, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Topically applied standardized aqueous extract of Curcuma longa Linn. suppresses endotoxin-induced uveal inflammation in rats by Agarwal R1, Gupta SK, Agarwal P, Srivastava S. (PubMed)
(2) The anti-inflammatory effects of Curcuma longa and Berberis aristata in endotoxin-induced uveitis in rabbits by Gupta SK1, Agarwal R, Srivastava S, Agarwal P, Agrawal SS, Saxena R, Galpalli N. (PubMed)
(3) Uveitis in the Aging Eye: Incidence, Patterns, and Differential Diagnosis by Marwan R. Abdulaal, Bachir H. Abiad, and Rola N. Hamam. (PMC)
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