Kyle J. Norton
Cardiovascular disease (CVD) is a class of diseases associated with blockage of blood vessels that heart disease and stroke, depending on the affected location.
Most cases of CVD are caused by reduced oxygen-rich blood inducing heart damage or the death of neurons in the brain.
In other words, if the reduced oxygen-rich blood flow occurs in the heart, it causes heart disease. On the other hand, if the reduced rich oxygen blood occurs in the brain, it causes a stroke.
Most cases of CVD in the Western world is coronary heart disease involved in plaque accumulated on the arterial wall due to an unhealthy diet with high saturated and trans fat and a lifestyle such as smoking accompanied by an overdose of the supplement of calcium.
According to the US statistics, from 2006 to 2016, the US death rate from CVD decreased by 18.6% and from coronary heart disease by 31.8%.
Believe it or not, CVD has caused a significant burden in the US healthcare system with the annual total cost at $351.2 billion in 2014-2015, with $213.8 billion in direct cost, including 46% for inpatient care.
Some researchers suggested that the increase of CVD, particularly in coronary heart disease at the alarming rate in the US, is probably associated with the promotion of a high-fat diet over the past few decades, accompanied by a sedentary lifestyle.
Dr. Jane E Freedman wrote, "Over the past two decades, significant progress has been made in the treatment of acute and chronic cardiovascular disease".
"According to the National Center for Health Statistics (1999), 61% of adults in the U.S. are overweight (body mass index [BMI] 25 to 29.9 kg/m2), and 26% are obese (BMI ≥30 kg/m2). Elevated BMI, particularly caused by abdominal or upper-body obesity, has been associated with diseases and metabolic abnormalities including hyperinsulinemia, insulin resistance, type 2 diabetes, hypertension, dyslipidemia, and coronary heart disease".
Additionally, "Dietary intake of specific nutrients has been suggested as a means of modifying the progression of cardiovascular disease. One such example is the proposed use of foods rich in select vitamins or flavonoids. Epidemiologic studies have reported an inverse relationship between the total dietary intake of plant flavonoids and the incidence of cardiovascular disease".
In other words, if you follow a high-fat diet, you are at substantial risk of diseases associated with obesity, including CVD.
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.
In finding a natural compound that has a potential effect on endothelium in the onset of cardiovascular diseases(CVD), researchers examined the water/ethanol extract of Cucumis sativus L. (CSE) fruit anti CVD activity.
The study included water/ethanol extract of Cucumis sativus L. (CSE) fruit effect in the attenuation of the damaging effect of pro-inflammatory lipopolysaccharide (LPS) in vitro model of endothelial cells associated with the onset of CVD.
According to the tested assay, administration of CSE reduced LPS-induced cytotoxicity and decreased cellular detachment, restoring the expression of tight junction ZO-1 in the contribution to barrier function.
In protein analysis, Cucumis sativus L. inhibited the early secretion of inflammatory IL-8 and Granulocyte-macrophage colony-stimulating factor (GM-CSF) and inflammatory cytokines IL-6 and IL-1α occurred late at 7 and 24 h respectively.
Additionally, in the prevention of the overexpression of pro-inflammatory cytokines, CSE stimulated the secretion of anti-inflammatory IL-10 and increased the production of IL-18 and IFN-γ in the modulation of the immune response.
Furthermore, according to the tested dose differentiation, the angiogenetic activity induced by inflammatory LPS was also prevented by the injection of Cucumis sativus L. extract.
Dr. wrote, at the end of the experiment, " Our results have clearly demonstrated that Cucumis sativus L. extract has attenuated lipopolysaccharide-induced inflammatory response in endothelial cells (associated with the risk of CVD)".
Moreover, in vivo, the compounds of Cucumis melo L. protected the impairment of the endothelial barrier associated with the risk of CVD induced by intraperitoneal injection of a high dose of CuEC (2 mg/kg).
In other words, cucurbitacins at a higher dose can induce toxicity to the cells of the endothelium, however, at low doses, CuEC (1 mg/kg) can lead to a decline in systolic blood pressure (SBP) without causing toxicity in mice by suppressing the angiotensin II (Ang II)-induced SBP increase.
Interestingly, the efficacy of CuEC's antihypertensive property was involved in facilitating acetylcholine-mediated vasodilation in the mesenteric arteries of tested mice.
Researchers after taking into account co and con-founders said, " In vitro studies showed that CuEC induced vasodilation in a dose-dependent manner in mesenteric arteries of both mice and rats. Pretreatment with CuEC inhibited phenylephrine-mediated vasoconstriction".
Taken together, cucumber and its bioactive compound cucurbitacin B (CuB) at the lower dose may be used for the treatment of cardiovascular diseases, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best BeforeKarate it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Water/ethanol extract of Cucumis sativus L. fruit attenuates lipopolysaccharide-induced inflammatory response in endothelial cells by Bernardini C1, Zannoni A2, Bertocchi M2, Tubon I2, Fernandez M2, Forni M. (PubMed)
(2) Cucurbitacins extracted from Cucumis melo L. (CuEC) exert a hypotensive effect via regulating vascular tone Ru-Qiang Yuan, Lei Qian, Wei-Jing Yun, Xiao-Hui Cui, Guang-Xin Lv, Wei-Qi Tang, Ri-Chang Cao & Hu Xu. (Hypertensive Research)
(3) High-fat diets and cardiovascular disease. Are nutritional supplements useful? by Jane E Freedman. (Journal of the American College of Cardiology)
Monday, 30 October 2023
#Eggplant Inhibits Enzymes Associated with the Risk the Type 2 #Diabetes, Scientists Show
Kyle J. Norton
Eggplant, the night shape fruit or vegetable may have a strong effect in reducing the risk and treatment of type 2 diabetes, some researchers suggested.
Type 2 diabetes is a condition caused by insufficient insulin entering the bloodstream to regulate glucose.
Insulin resistance is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
According to the US statistics in 2015, approximately 30.3 million Americans, or 9.4% of the population, had diabetes. and 1.25 million American children and adults have type 1 diabetes.
Some researchers suggested that the widespread type 2 diabetes in the US was associated with the promotion of the Western diet which has been found to complicate the risk of insulin receptor sites clogged up by fat and cholesterol, affecting the receptor in absorbing and releasing insulin from and to the body.
Dr. Merat S, the lead scientist in the study of a group of mice involved the Western diet risk of insulin resistance and hyperinsulinemia wrote, "The Western diet group had higher average glucose levels (187+/-16 versus 159+/-12 mg/dL) and 4.5-fold higher plasma insulin levels".and "the Western diets commonly used in LDLR-/- mice may not only induce atherosclerosis but also IR, potentially complicating the interpretation of results".
These results firmly suggested long-term followers of the Western diet high in saturated and trans fat, red meat, processed foods, and low in fruits and vegetables are the main culprits for the onset of insulin resistance, the early stage of type 2 diabetes.
Therefore, by changing to a healthy diet that reduces the intake of total fat (saturated fatty acids in particular) and increases the intake of dietary fiber by consuming more vegetables and fruits and whole-grain cereal products, diabetes is preventable.
Dr. Matti Uusitupa, MD, in the article "Lifestyles Matter in the Prevention of Type 2 Diabetes" quoted, "In a Swedish uncontrolled study shown that an increase in physical activity and moderate weight loss reduced the incidence of type 2 diabetes by 50% in middle-aged men with IGT" and
"In a Chinese study of IGT patients, 6-year interventions with diet, physical activity, and diet plus physical activity resulted in an approximate 30–40% reduction in diabetes risk in both normal weight and overweight persons".
Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
The vegetable is famous for its deep purple and the best eggplant can be found from August through October when it is in the season. While it's generally thought of as a vegetable, eggplant is actually a fruit.
Chemical constituents
The vegetable chemical compounds containing include sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids, and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin, and other Polyphenolic compounds.
In the concerns of the widespread type 2 diabetes among Americans, researchers launched an investigation to examine the National Diabetes Education Program of NIH, Mayo Clinic, and American Diabetes Association recommendation of an eggplant-based diet as a choice for the management of type 2 diabetes.
The recommendation is based on the rationale is the high fiber and low soluble carbohydrate content of eggplant.
Application of phenolic-enriched extracts of eggplant showed a moderate free radical scavenging-linked antioxidant activity and high alpha-glucosidase inhibition by preventing the glucosidase in breaking down starch and disaccharides to glucose and moderate to high angiotensin I-converting enzyme (ACE) inhibition activity in the prevention of β-cell dysfunction and apoptosis occurring in type 2diabetes.
By inhibiting these enzymes researchers suggested that intake of eggplant should provide a strong biochemical basis for managing type 2 diabetes by controlling glucose absorption.
Dr.Kwon YI, the lead author said, "phenolic antioxidant-enriched dietary strategy also has the potential to reduce hyperglycemia-induced pathogenesis linked to cellular oxidation stress".
Further analysis of the phenolic antioxidant in the eggplant, researchers conducted an experiment on the member chlorogenic acids (CGAs) in chronic diseases including diabetes, by searching the database of online medical literature.
* The biological properties of CGA in addition to its antioxidant and anti-inflammatory effects were found in some studies.
* CGA was found to exert pivotal roles in glucose and lipid metabolism regulation and in related disorders, e.g. diabetes, cardiovascular disease (CVD), obesity, cancer, and hepatic steatosis.
* CGA demonstrated a wide range of potential health benefits, including its anti-diabetic, anti-carcinogenic, anti-inflammatory, and anti-obesity impacts, which may provide a non-pharmacological and non-invasive approach.
Taken together, eggplant processed with a high amount of phenolic compound may be considered a functional vegetable in the prevention of type 2 diabetes and an adjunct therapy combined with primary medicine for the treatment of the disease.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension by Kwon YI1, Apostolidis E, Shetty K.(PubMed)
(2) in outlook on chlorogenic acids-occurrence, chemistry, technology, and biological activities by Upadhyay R1, Mohan Rao LJ.(PubMed)
(3) Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet by Merat S1, Casanada F, Sutphin M, Palinski W, Reaven PD. (PubMed)
(4) Lifestyles Matter in the Prevention of Type 2 Diabetes by Matti Uusitupa, MD
Eggplant, the night shape fruit or vegetable may have a strong effect in reducing the risk and treatment of type 2 diabetes, some researchers suggested.
Type 2 diabetes is a condition caused by insufficient insulin entering the bloodstream to regulate glucose.
Insulin resistance is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
According to the US statistics in 2015, approximately 30.3 million Americans, or 9.4% of the population, had diabetes. and 1.25 million American children and adults have type 1 diabetes.
Some researchers suggested that the widespread type 2 diabetes in the US was associated with the promotion of the Western diet which has been found to complicate the risk of insulin receptor sites clogged up by fat and cholesterol, affecting the receptor in absorbing and releasing insulin from and to the body.
Dr. Merat S, the lead scientist in the study of a group of mice involved the Western diet risk of insulin resistance and hyperinsulinemia wrote, "The Western diet group had higher average glucose levels (187+/-16 versus 159+/-12 mg/dL) and 4.5-fold higher plasma insulin levels".and "the Western diets commonly used in LDLR-/- mice may not only induce atherosclerosis but also IR, potentially complicating the interpretation of results".
These results firmly suggested long-term followers of the Western diet high in saturated and trans fat, red meat, processed foods, and low in fruits and vegetables are the main culprits for the onset of insulin resistance, the early stage of type 2 diabetes.
Therefore, by changing to a healthy diet that reduces the intake of total fat (saturated fatty acids in particular) and increases the intake of dietary fiber by consuming more vegetables and fruits and whole-grain cereal products, diabetes is preventable.
Dr. Matti Uusitupa, MD, in the article "Lifestyles Matter in the Prevention of Type 2 Diabetes" quoted, "In a Swedish uncontrolled study shown that an increase in physical activity and moderate weight loss reduced the incidence of type 2 diabetes by 50% in middle-aged men with IGT" and
"In a Chinese study of IGT patients, 6-year interventions with diet, physical activity, and diet plus physical activity resulted in an approximate 30–40% reduction in diabetes risk in both normal weight and overweight persons".
Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
The vegetable is famous for its deep purple and the best eggplant can be found from August through October when it is in the season. While it's generally thought of as a vegetable, eggplant is actually a fruit.
Chemical constituents
The vegetable chemical compounds containing include sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids, and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin, and other Polyphenolic compounds.
In the concerns of the widespread type 2 diabetes among Americans, researchers launched an investigation to examine the National Diabetes Education Program of NIH, Mayo Clinic, and American Diabetes Association recommendation of an eggplant-based diet as a choice for the management of type 2 diabetes.
The recommendation is based on the rationale is the high fiber and low soluble carbohydrate content of eggplant.
Application of phenolic-enriched extracts of eggplant showed a moderate free radical scavenging-linked antioxidant activity and high alpha-glucosidase inhibition by preventing the glucosidase in breaking down starch and disaccharides to glucose and moderate to high angiotensin I-converting enzyme (ACE) inhibition activity in the prevention of β-cell dysfunction and apoptosis occurring in type 2diabetes.
By inhibiting these enzymes researchers suggested that intake of eggplant should provide a strong biochemical basis for managing type 2 diabetes by controlling glucose absorption.
Dr.Kwon YI, the lead author said, "phenolic antioxidant-enriched dietary strategy also has the potential to reduce hyperglycemia-induced pathogenesis linked to cellular oxidation stress".
Further analysis of the phenolic antioxidant in the eggplant, researchers conducted an experiment on the member chlorogenic acids (CGAs) in chronic diseases including diabetes, by searching the database of online medical literature.
* The biological properties of CGA in addition to its antioxidant and anti-inflammatory effects were found in some studies.
* CGA was found to exert pivotal roles in glucose and lipid metabolism regulation and in related disorders, e.g. diabetes, cardiovascular disease (CVD), obesity, cancer, and hepatic steatosis.
* CGA demonstrated a wide range of potential health benefits, including its anti-diabetic, anti-carcinogenic, anti-inflammatory, and anti-obesity impacts, which may provide a non-pharmacological and non-invasive approach.
Taken together, eggplant processed with a high amount of phenolic compound may be considered a functional vegetable in the prevention of type 2 diabetes and an adjunct therapy combined with primary medicine for the treatment of the disease.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension by Kwon YI1, Apostolidis E, Shetty K.(PubMed)
(2) in outlook on chlorogenic acids-occurrence, chemistry, technology, and biological activities by Upadhyay R1, Mohan Rao LJ.(PubMed)
(3) Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet by Merat S1, Casanada F, Sutphin M, Palinski W, Reaven PD. (PubMed)
(4) Lifestyles Matter in the Prevention of Type 2 Diabetes by Matti Uusitupa, MD
#Fennel Protects the Liver Against Toxicity, According to Studies
Kyle J. Norton
Fennel may be considered a functional food in exhibited liver protective effect against toxicity, some scientists suggested.
Liver protection is an action that prevents injury and damage to the liver, regardless of the causes.
Researchers do not know the exact cause of liver disease. However, they do know that genes inherited from the parents, aging, and viral and bacterial infection are associated with the increased risk of liver disease.
Additionally, long-term excessive alcohol drinking and obesity are also some prevalent risk factors for the onset of liver disease.
Untreated liver disease or liver disease that is not treated properly over time can increase the risk of cirrhosis, a leading cause of liver failure and a life-threatening condition.
Dr. William Nseir, the lead author in the assessment of the role of diet and lifestyle changes in nonalcoholic fatty liver disease wrote, "A combination of dietary modifications and increased physical activity remains the mainstay of NAFLD management. It is hard to maintain this mode of management; however, it seems to have significant long-term benefits" "Furthermore, NAFLD patients, whether obese or not, should be educated that a healthy diet and physical activity have benefits beyond weight reduction".
These results suggested that a change in diet and lifestyle with moderate exercise may have a strong effect on the prevention of liver disease.
Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, and antidepressant agent and nd to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
In the evaluation of the liver protective effect against acute hepatotoxicity induced by carbon tetrachloride (CLL4) in the rat model, researchers found that oral administration of essential oil isolated from the fennel exerts a strong activity in the decrease of levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and bilirubin, the potential causes of liver damage through their toxic effects.
Further analysis insisted that the hepatoprotective activity of the essential oil was attributed to the expression of phytochemical constituents d-limonene and β-myrcene in the inhibition of the levels of carbon tetrachloride in catalyzing liver toxicity and initiating liver lesion and liver fibrosis.
Additional differentiation of the hepatic fibrosis model in rats induced by subcutaneous injection with 40% CCl4 olive oil mixture with 94 male SD rats given high lipoid-low protein animal feeds for 5 weeks then randomly divided into six groups, including blank control group (A-group), 8 rats was feed in normal, prevention model control group (B-group), 10 rats given saline solution by intragastric administration during the make of hepatic fibrosis model and FVM prevention group (C-group), 10 rats given FVM by intragastric administration during the make of hepatic fibrosis model; model control group (D-group), FVM treatment group (E-group) and Fuzhenghuayu treatment group (F-group), after assessing the results from the 5-th weekend, A, B, C- group rats sacrificed at the 6-th, 7-th, 8-th, 9-th weekend and 4-6 rats in D, E, F-group sacrificed., researchers indicated that
* The expression of alpha-smooth muscle actin(a-SMA) associated with liver damage and correlated positively in the recurrent HCV hepatitis group is significantly higher in the HBV cirrhosis detected by immunohistochemical staining assay.
* Serum alanine aminotransferase (ALT), an amino acid found in proteins and intermediate in cellular energy production presented in the blood of tested subjects may be an indication of liver damage.
Low levels of ALT are found in the blood profiles of healthy individuals.
* Similar to ALT, aspartate aminotransferase (AST) is an enzyme associated with the liver parenchymal cell and presented in low levels in the blood of healthy individuals but significantly higher in liver damage tested rats.
* Hyaluronic acid (HA) is distributed widely throughout connective, epithelial, and neural tissues, the prediction of liver damage, particularly in the risk of liver fibrosis.
* Increased levels of Laminin (LN), a protein of the extracellular matrix, is also associated with a substantial risk of the development of liver fibrosis.
* Overexpression of levels of 8 - hydroxy-2-deoxyguanosine (8-OHdG) is another indication of oxidative stress and is also considered a critical biomarker of carcinogenesis.
The increased levels of the above expressions suggested substantial damage to the liver caused by ingestion of CCL4 in the non-fennel treatment group
However, application of fennel in such groups inhibited the overexpression of toxicity caused by the injection of CCL4 by restoring the normal levels of Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), laminin (LN) and 8 - hydroxy-2-deoxyguanosine (8-OHdG).
Further analysis also showed that oral administration of fennel inhibited the levels of malondialdehyde (MDA) in precipitated oxidative stress through lipid peroxidation.
Some researchers suggested that levels of MDA may be used as a biomarker in the assessment of oxidative stress status in patients with liver disease or cancer.
Moreover, injection of fennel exerted liver protective and anti-inflammatory effects through its antioxidants overexpression and improved production of natural antioxidants in the host tissue such as superoxide dismutase (SOD), glutathione peroxidase levels in inhibited oxidative stress initiated by CCL4
Precisely, fennel significantly decreased expression serums of ALT, AST, HA, LN and MDA, 8-OHdG, fiber, and a-SMA expression in the FVM group and lowered inflammation grade and fibrosis stage compared to the control group.
Dr. Zhang ZG, the lead author, after taking into account other co-founders said, "Foeniculum Vulgare Mill declines liver inflammation response, and prevents the hepatic fibrosis progression,, this may be due to its effects of antioxidative results".
The findings suggested that fennel with abundant bioactive anethole may be considered a functional food in exhibited hepatoprotective effect through its anti-inflammatory and antioxidant activities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shortShorty Awardy award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hepatoprotective effect of Foeniculum vulgare essential oil by Ozbek H1, Uğraş S, Dülger H, Bayram I, Tuncer I, Oztürk G, Oztürk A.(PubMed)
(2) [Antioxidant effects of the Uygur herb, Foeniculum Vulgare Mill, in a rat model of hepatic fibrosis].[Article in Chinese] by Zhang ZG1, Lu XB, Xiao L, Tang L, Zhang LJ, Zhang T, Zhan XY, Ma XM, Zhang YX(PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
Fennel may be considered a functional food in exhibited liver protective effect against toxicity, some scientists suggested.
Liver protection is an action that prevents injury and damage to the liver, regardless of the causes.
Researchers do not know the exact cause of liver disease. However, they do know that genes inherited from the parents, aging, and viral and bacterial infection are associated with the increased risk of liver disease.
Additionally, long-term excessive alcohol drinking and obesity are also some prevalent risk factors for the onset of liver disease.
Untreated liver disease or liver disease that is not treated properly over time can increase the risk of cirrhosis, a leading cause of liver failure and a life-threatening condition.
Dr. William Nseir, the lead author in the assessment of the role of diet and lifestyle changes in nonalcoholic fatty liver disease wrote, "A combination of dietary modifications and increased physical activity remains the mainstay of NAFLD management. It is hard to maintain this mode of management; however, it seems to have significant long-term benefits" "Furthermore, NAFLD patients, whether obese or not, should be educated that a healthy diet and physical activity have benefits beyond weight reduction".
These results suggested that a change in diet and lifestyle with moderate exercise may have a strong effect on the prevention of liver disease.
Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, and antidepressant agent and nd to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
In the evaluation of the liver protective effect against acute hepatotoxicity induced by carbon tetrachloride (CLL4) in the rat model, researchers found that oral administration of essential oil isolated from the fennel exerts a strong activity in the decrease of levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and bilirubin, the potential causes of liver damage through their toxic effects.
Further analysis insisted that the hepatoprotective activity of the essential oil was attributed to the expression of phytochemical constituents d-limonene and β-myrcene in the inhibition of the levels of carbon tetrachloride in catalyzing liver toxicity and initiating liver lesion and liver fibrosis.
Additional differentiation of the hepatic fibrosis model in rats induced by subcutaneous injection with 40% CCl4 olive oil mixture with 94 male SD rats given high lipoid-low protein animal feeds for 5 weeks then randomly divided into six groups, including blank control group (A-group), 8 rats was feed in normal, prevention model control group (B-group), 10 rats given saline solution by intragastric administration during the make of hepatic fibrosis model and FVM prevention group (C-group), 10 rats given FVM by intragastric administration during the make of hepatic fibrosis model; model control group (D-group), FVM treatment group (E-group) and Fuzhenghuayu treatment group (F-group), after assessing the results from the 5-th weekend, A, B, C- group rats sacrificed at the 6-th, 7-th, 8-th, 9-th weekend and 4-6 rats in D, E, F-group sacrificed., researchers indicated that
* The expression of alpha-smooth muscle actin(a-SMA) associated with liver damage and correlated positively in the recurrent HCV hepatitis group is significantly higher in the HBV cirrhosis detected by immunohistochemical staining assay.
* Serum alanine aminotransferase (ALT), an amino acid found in proteins and intermediate in cellular energy production presented in the blood of tested subjects may be an indication of liver damage.
Low levels of ALT are found in the blood profiles of healthy individuals.
* Similar to ALT, aspartate aminotransferase (AST) is an enzyme associated with the liver parenchymal cell and presented in low levels in the blood of healthy individuals but significantly higher in liver damage tested rats.
* Hyaluronic acid (HA) is distributed widely throughout connective, epithelial, and neural tissues, the prediction of liver damage, particularly in the risk of liver fibrosis.
* Increased levels of Laminin (LN), a protein of the extracellular matrix, is also associated with a substantial risk of the development of liver fibrosis.
* Overexpression of levels of 8 - hydroxy-2-deoxyguanosine (8-OHdG) is another indication of oxidative stress and is also considered a critical biomarker of carcinogenesis.
The increased levels of the above expressions suggested substantial damage to the liver caused by ingestion of CCL4 in the non-fennel treatment group
However, application of fennel in such groups inhibited the overexpression of toxicity caused by the injection of CCL4 by restoring the normal levels of Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), laminin (LN) and 8 - hydroxy-2-deoxyguanosine (8-OHdG).
Further analysis also showed that oral administration of fennel inhibited the levels of malondialdehyde (MDA) in precipitated oxidative stress through lipid peroxidation.
Some researchers suggested that levels of MDA may be used as a biomarker in the assessment of oxidative stress status in patients with liver disease or cancer.
Moreover, injection of fennel exerted liver protective and anti-inflammatory effects through its antioxidants overexpression and improved production of natural antioxidants in the host tissue such as superoxide dismutase (SOD), glutathione peroxidase levels in inhibited oxidative stress initiated by CCL4
Precisely, fennel significantly decreased expression serums of ALT, AST, HA, LN and MDA, 8-OHdG, fiber, and a-SMA expression in the FVM group and lowered inflammation grade and fibrosis stage compared to the control group.
Dr. Zhang ZG, the lead author, after taking into account other co-founders said, "Foeniculum Vulgare Mill declines liver inflammation response, and prevents the hepatic fibrosis progression,, this may be due to its effects of antioxidative results".
The findings suggested that fennel with abundant bioactive anethole may be considered a functional food in exhibited hepatoprotective effect through its anti-inflammatory and antioxidant activities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shortShorty Awardy award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hepatoprotective effect of Foeniculum vulgare essential oil by Ozbek H1, Uğraş S, Dülger H, Bayram I, Tuncer I, Oztürk G, Oztürk A.(PubMed)
(2) [Antioxidant effects of the Uygur herb, Foeniculum Vulgare Mill, in a rat model of hepatic fibrosis].[Article in Chinese] by Zhang ZG1, Lu XB, Xiao L, Tang L, Zhang LJ, Zhang T, Zhan XY, Ma XM, Zhang YX(PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
#Healthyfood #Broccoli Does Not Process a Short Term Benefit in the Inhibition of Asthmatic Symptoms, According to Studies
Kyle J. Norton
Respiratory Disease is a medical condition that affects the breathing organs and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc.
The lungs are a pair of organs located on either side of the chest (thorax) with a function to bring fresh oxygen into the body and remove carbon dioxide and other waste gases from the body.
According to the statistics provided by the Lung Association over 3 million Canadians are affected by one of five serious respiratory diseases – asthma, chronic obstructive pulmonary disease (COPD), lung cancer, tuberculosis (TB), and cystic fibrosis.
In 2017, 28,600 Canadians were diagnosed with lung cancer, representing 14% of all new cancer cases. Lung cancer caused the death of 21,100 Canadians in the same year.
Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages and mostly starts during childhood.
Besides episodes of wheezing, coughing, chest tightness, and shortness of breath, patients with asthma also experience symptoms of reversible airflow obstruction and bronchospasm.
Asthma attack in most cases is triggered by exposure to various irritants and substances that trigger allergies (allergens). However, genetic preposition and family history are also found in patients with asthma.
Asthma in some cases can interfere with daily activities and may lead to a life-threatening asthma attack. Treatment of asthma is to reduce the frequent episodes and severity of the attacks.
According to the statistics provided by the Centers for Disease Control and Prevention (CDC), in the US, 1 in 13 people have asthma. In other words, over 26 million Americans have asthma and half of that is children.
Believe it or not, African Americans in the U.S. die from asthma at a higher rate than people of other races or ethnicities.
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
To find a natural food for the prevention and treatment of respiratory diseases, researchers examined the effect of Broccoli sprouts (BS) on airway inflammatory and physiologic outcomes, and OS in adults with asthma and allergic sensitization to an indoor allergen.
A double-blind, placebo-controlled, randomized trial to compare the effects of BS with placebo (alfalfa sprouts [AS]) on airway inflammation and markers of OS included 40 adults (aged 18-50 years) who were randomized to eat either (a) 100 g of BS daily or (b) 100 g of AS daily for 3 days.
According to the tested analysis,
* BS ingestion for 3 consecutive days did not reduce FeNO in asthma, despite causing a marked increase in serum SFN concentrations (21 vs 22 parts per billion, P = .76).
* Furthermore, BS administration did not induce cytoprotective antioxidant genes in either PBMCs or nasal epithelial cells,
* Moreover, BS consumption did not reduce OS and inflammatory markers or improve lung function.
In other words, short-term interference of BS showed no improvement in the symptoms in asthmatic patients
Based on the results, researchers wrote, " Ingestion of the whole BS for 3 days does not appear to improve eosinophilic pulmonary inflammation, inflammatory and OS biomarkers, or clinical features of asthma among atopic adults with asthma despite resulting in a marked increase in serum SFN levels."
And "However, because variability exists in the timing and methods of detection for SFN conjugate levels, it is difficult to compare systemic SFN levels across studies".
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A Randomized Controlled Trial of the Effect of Broccoli Sprouts on Antioxidant Gene Expression and Airway Inflammation in Asthmatics by Sudini K1, Diette GB2, Breysse PN3, McCormack MC2, Bull D4, Biswal S5, Zhai S4, Brereton N6, Peng RD7, Matsui EC. (PubMed)
Respiratory Disease is a medical condition that affects the breathing organs and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc.
The lungs are a pair of organs located on either side of the chest (thorax) with a function to bring fresh oxygen into the body and remove carbon dioxide and other waste gases from the body.
According to the statistics provided by the Lung Association over 3 million Canadians are affected by one of five serious respiratory diseases – asthma, chronic obstructive pulmonary disease (COPD), lung cancer, tuberculosis (TB), and cystic fibrosis.
In 2017, 28,600 Canadians were diagnosed with lung cancer, representing 14% of all new cancer cases. Lung cancer caused the death of 21,100 Canadians in the same year.
Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages and mostly starts during childhood.
Besides episodes of wheezing, coughing, chest tightness, and shortness of breath, patients with asthma also experience symptoms of reversible airflow obstruction and bronchospasm.
Asthma attack in most cases is triggered by exposure to various irritants and substances that trigger allergies (allergens). However, genetic preposition and family history are also found in patients with asthma.
Asthma in some cases can interfere with daily activities and may lead to a life-threatening asthma attack. Treatment of asthma is to reduce the frequent episodes and severity of the attacks.
According to the statistics provided by the Centers for Disease Control and Prevention (CDC), in the US, 1 in 13 people have asthma. In other words, over 26 million Americans have asthma and half of that is children.
Believe it or not, African Americans in the U.S. die from asthma at a higher rate than people of other races or ethnicities.
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
To find a natural food for the prevention and treatment of respiratory diseases, researchers examined the effect of Broccoli sprouts (BS) on airway inflammatory and physiologic outcomes, and OS in adults with asthma and allergic sensitization to an indoor allergen.
A double-blind, placebo-controlled, randomized trial to compare the effects of BS with placebo (alfalfa sprouts [AS]) on airway inflammation and markers of OS included 40 adults (aged 18-50 years) who were randomized to eat either (a) 100 g of BS daily or (b) 100 g of AS daily for 3 days.
According to the tested analysis,
* BS ingestion for 3 consecutive days did not reduce FeNO in asthma, despite causing a marked increase in serum SFN concentrations (21 vs 22 parts per billion, P = .76).
* Furthermore, BS administration did not induce cytoprotective antioxidant genes in either PBMCs or nasal epithelial cells,
* Moreover, BS consumption did not reduce OS and inflammatory markers or improve lung function.
In other words, short-term interference of BS showed no improvement in the symptoms in asthmatic patients
Based on the results, researchers wrote, " Ingestion of the whole BS for 3 days does not appear to improve eosinophilic pulmonary inflammation, inflammatory and OS biomarkers, or clinical features of asthma among atopic adults with asthma despite resulting in a marked increase in serum SFN levels."
And "However, because variability exists in the timing and methods of detection for SFN conjugate levels, it is difficult to compare systemic SFN levels across studies".
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A Randomized Controlled Trial of the Effect of Broccoli Sprouts on Antioxidant Gene Expression and Airway Inflammation in Asthmatics by Sudini K1, Diette GB2, Breysse PN3, McCormack MC2, Bull D4, Biswal S5, Zhai S4, Brereton N6, Peng RD7, Matsui EC. (PubMed)
#Ginger Inhibits Enzymes and Stress Markers Associated with the Risk of Type 2 #Diabetes, Scientists Say
Kyle J. Norton
Ginger may be next generation whole food used for the prevention and treatment of type 2 diabetes, with no side effects, some scientists suggested.
Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate glucose due to either cell in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
Researchers do not know what causes the pancreas to die off or receptor sites clogged up. However, they do know obesity or overweight, gender, ethnicity, age, family history, and gestation diabetes, are associated with an increased risk of type 2 diabetes.
Some researchers also suggested that people with certain medical conditions such as polycystic ovary syndrome. and high blood pressure is more prone to the onset of the disease.
The most common symptoms of type 2 diabetes are increased thirst that won't stop with water intake, increased hunger (especially after eating), dry mouth, frequent urination, and unintentional weight loss.
If you experience some of the symptoms above, please make you check with your doctor to rule out the possibility of diabetes.
According to statistics, diabetes is one of the most common disease in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million who are undiagnosed and unaware of their condition.
About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.
Dr. Rita R. Kalyani in the study to examine the increase with age and risk of type 2 diabetes wrote, "The unprecedented aging of the world's population is a major contributor to the diabetes epidemic, and older adults represent one of the fastest-growing segments of the diabetes population".
"Almost one-third of U.S. adults over the age of 65 years have diabetes. Approximately half of those are undiagnosed, and an additional one-third of older adults have prediabetes" and "management of older adults with diabetes is clearly more complicated given the observation that they commonly have multiple coexisting medical conditions that can impact clinical management".
Compared to the general population risk of type 2 diabetes, the results clearly stated, the risk of type diabetes in elderly is 3 fold higher and the management of the disease is more difficult due accompanied by other medical conditions, such as high blood pressure and cholesterol
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural whole food for the prevention and treatment of diabetes with little or no side effects, researchers looked into the effects of ginger consumption on glycemic status, lipid profile, and some inflammatory markers in patients with type 2 diabetes mellitus.
The double-blinded, placebo-controlled clinical trial, included 70 types 2 diabetic patients allocated randomly into the ginger group consumed 1600 mg ginger, and the control group consumed 1600 mg wheat flour daily for 12 weeks.
Patients treated with ginger demonstrated a significant effect in reducing the levels of fasting plasma glucose, 3 months average glucose concentration, and insulin resistance.
Furthermore, the blood profile of the treatment group also displayed lower levels of triglyceride, total cholesterol, a hormone associated with lipid peroxidation. compared to the placebo group.
There were no significant differences in high-density lipoprotein (HDL), low-density lipoprotein LDL, and TNFα, the inflammatory cytokine between the two groups.
The findings firmly indicated ginger improves insulin sensitivity and some fractions of lipid profiles and reduces inflammation in type 2 diabetic patients.
Additionally, with an aim to reaffirm the effects of ginger against the development of type 2 diabetes and diabetic complications, researchers investigated the effect of ginger supplementation on glycemic indices in Iranian patients with type 2 diabetes.
The double-blind, placebo-controlled, randomized clinical trial included 20-60 -60-year-old patients with type 2 diabetes who did not receive insulin.
Participants in the intervention and control groups received 3 g of powdered ginger or placebo (lactose) (in capsules) daily for 3 months.
At the end of the 3 months, researchers showed that all parameters associated with diabetes were reduced substantially in the treatment group compared to control.
More precisely, the differences between the ginger and placebo groups were statistically significant as follows: serum glucose (-19.41 ± 18.83 vs. 1.63 ± 4.28 mg/dL, p < 0.001), (Hemoglobin A1C)HbA1c percentage (-0.77 ± 0.88 vs. 0.02 ± 0.16%, p < 0.001), insulin (-1.46 ± 1.7 vs. 0.09 ± 0.34 μIU/mL, p < 0.001), insulin resistance (-16.38 ± 19.2 vs. 0.68 ± 2.7, p < 0.001), high-sensitive CRP (-2.78 ± 4.07 vs. 0.2 ± 0.77 mg/L, p < 0.001), paraoxonase-1 (PON-1) (22.04 ± 24.53 vs. 1.71 ± 2.72 U/L, p < 0.006), total antioxidant capacity (TAC) (0.78 ± 0.71 vs. -0.04 ± 0.29 µIU/mL, p < 0.01) and MDA (-0.85 ± 1.08 vs. 0.06 ± 0.08 µmol/L, p < 0.001) were significantly different.
Where paraoxonase ((PON)-1 is an enzyme associated with the protection against lipid oxidation, Malondialdehyde (MDA) is an oxidative stress marker.
Dr. Shidfar F, the lead scientist said, "The 3 months supplementation of ginger improved glycemic indices, TAC and PON-1 activity in patients with type 2 diabetes".
Taken together, ginger may be considered a functional food for the prevention and combined with the primary therapy for the treatment of type 2 diabetes with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus by Arablou T1, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. (PubMed)
(2) Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients by Mahluji S1, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. (PubMed)
(3) The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes by Shidfar F, Rajab A, Rahideh T, Khandouzi N, Hosseini S, Shidfar S. (PubMed)
(4) Diabetes and Aging: Unique Considerations and Goals of Care, Rita R. Kalyani, Sherita H. Golden and William T. Cefalu. (Diabetes Care)
Ginger may be next generation whole food used for the prevention and treatment of type 2 diabetes, with no side effects, some scientists suggested.
Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate glucose due to either cell in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
Researchers do not know what causes the pancreas to die off or receptor sites clogged up. However, they do know obesity or overweight, gender, ethnicity, age, family history, and gestation diabetes, are associated with an increased risk of type 2 diabetes.
Some researchers also suggested that people with certain medical conditions such as polycystic ovary syndrome. and high blood pressure is more prone to the onset of the disease.
The most common symptoms of type 2 diabetes are increased thirst that won't stop with water intake, increased hunger (especially after eating), dry mouth, frequent urination, and unintentional weight loss.
If you experience some of the symptoms above, please make you check with your doctor to rule out the possibility of diabetes.
According to statistics, diabetes is one of the most common disease in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million who are undiagnosed and unaware of their condition.
About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.
Dr. Rita R. Kalyani in the study to examine the increase with age and risk of type 2 diabetes wrote, "The unprecedented aging of the world's population is a major contributor to the diabetes epidemic, and older adults represent one of the fastest-growing segments of the diabetes population".
"Almost one-third of U.S. adults over the age of 65 years have diabetes. Approximately half of those are undiagnosed, and an additional one-third of older adults have prediabetes" and "management of older adults with diabetes is clearly more complicated given the observation that they commonly have multiple coexisting medical conditions that can impact clinical management".
Compared to the general population risk of type 2 diabetes, the results clearly stated, the risk of type diabetes in elderly is 3 fold higher and the management of the disease is more difficult due accompanied by other medical conditions, such as high blood pressure and cholesterol
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural whole food for the prevention and treatment of diabetes with little or no side effects, researchers looked into the effects of ginger consumption on glycemic status, lipid profile, and some inflammatory markers in patients with type 2 diabetes mellitus.
The double-blinded, placebo-controlled clinical trial, included 70 types 2 diabetic patients allocated randomly into the ginger group consumed 1600 mg ginger, and the control group consumed 1600 mg wheat flour daily for 12 weeks.
Patients treated with ginger demonstrated a significant effect in reducing the levels of fasting plasma glucose, 3 months average glucose concentration, and insulin resistance.
Furthermore, the blood profile of the treatment group also displayed lower levels of triglyceride, total cholesterol, a hormone associated with lipid peroxidation. compared to the placebo group.
There were no significant differences in high-density lipoprotein (HDL), low-density lipoprotein LDL, and TNFα, the inflammatory cytokine between the two groups.
The findings firmly indicated ginger improves insulin sensitivity and some fractions of lipid profiles and reduces inflammation in type 2 diabetic patients.
Additionally, with an aim to reaffirm the effects of ginger against the development of type 2 diabetes and diabetic complications, researchers investigated the effect of ginger supplementation on glycemic indices in Iranian patients with type 2 diabetes.
The double-blind, placebo-controlled, randomized clinical trial included 20-60 -60-year-old patients with type 2 diabetes who did not receive insulin.
Participants in the intervention and control groups received 3 g of powdered ginger or placebo (lactose) (in capsules) daily for 3 months.
At the end of the 3 months, researchers showed that all parameters associated with diabetes were reduced substantially in the treatment group compared to control.
More precisely, the differences between the ginger and placebo groups were statistically significant as follows: serum glucose (-19.41 ± 18.83 vs. 1.63 ± 4.28 mg/dL, p < 0.001), (Hemoglobin A1C)HbA1c percentage (-0.77 ± 0.88 vs. 0.02 ± 0.16%, p < 0.001), insulin (-1.46 ± 1.7 vs. 0.09 ± 0.34 μIU/mL, p < 0.001), insulin resistance (-16.38 ± 19.2 vs. 0.68 ± 2.7, p < 0.001), high-sensitive CRP (-2.78 ± 4.07 vs. 0.2 ± 0.77 mg/L, p < 0.001), paraoxonase-1 (PON-1) (22.04 ± 24.53 vs. 1.71 ± 2.72 U/L, p < 0.006), total antioxidant capacity (TAC) (0.78 ± 0.71 vs. -0.04 ± 0.29 µIU/mL, p < 0.01) and MDA (-0.85 ± 1.08 vs. 0.06 ± 0.08 µmol/L, p < 0.001) were significantly different.
Where paraoxonase ((PON)-1 is an enzyme associated with the protection against lipid oxidation, Malondialdehyde (MDA) is an oxidative stress marker.
Dr. Shidfar F, the lead scientist said, "The 3 months supplementation of ginger improved glycemic indices, TAC and PON-1 activity in patients with type 2 diabetes".
Taken together, ginger may be considered a functional food for the prevention and combined with the primary therapy for the treatment of type 2 diabetes with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus by Arablou T1, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. (PubMed)
(2) Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients by Mahluji S1, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. (PubMed)
(3) The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes by Shidfar F, Rajab A, Rahideh T, Khandouzi N, Hosseini S, Shidfar S. (PubMed)
(4) Diabetes and Aging: Unique Considerations and Goals of Care, Rita R. Kalyani, Sherita H. Golden and William T. Cefalu. (Diabetes Care)
#Healthy Food Cucumber Inhibits Diseases Associated with Overexpression of Oxidativestress, AQccording to Studies
Kyle J. Norton
Antioxidants are stable molecules that inhibit oxidation produced either by the liver or from the consumption of antioxidant-rich foods.
In other words, antioxidants inhibit the unstable free radicals with a single electron in the outermost ring that facilitates the domino's reaction to cause oxidative stress.
Free radicals are unstable molecules existing everywhere in the environment and in the body. The air we breathe the food we eat and cellular metabolism are found to induce the production of free radicals.
Free radicals in moderate are necessary for the proper function of our body, such as free radical NO which is needed to relax the blood vessels. However, overexpression of free radicals can induce oxidative stress in the tissues and organs, leading to protein, lipid, and cellular DNA damage.
Overexpression of oxidative stress over time has been linked to the onset of chronic diseases, inclduing arthritis, cardiovascular disease, diabetes, and cancer.
In a healthy individual, antioxidant enzymes produced by the body are good enough to neutralize the levels of free radicals in the body. However, people with a weakened immune system may need an additional dietary source of antioxidants.
The most common risk factors associated with oxidative stress are antioxidant deficiency in the body caused by demographic, physical, lifestyle, or nutritional factors.
Some researchers suggested people who smoke may be at an increased risk of oxidative stress.
Dr. the lead scientist wrote, "Cigarette smoking is a major risk factor for several human diseases. Chronic inflammation, resulting from increased oxidative stress, has been suggested as a mechanism that contributes to the increased susceptibility of smokers to cancer and microbial infections".
, "Several studies have indicated greater levels of oxidative stress in cigarette smokers [31, 32], which is most likely attributed to the high concentration of ROS and nitrogen species (RNS) in cigarette smoke [33–36]. In addition, cigarette smoke has been associated with elevated ROS production by leukocytes in the airways of both acute and chronic smokers [37]".
The results strongly suggested, if you smoke, your risk of diseases associated with oxidative stress increased substantially, compared to those who don't.
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.
With an aim to find a natural compound that processes antioxidative stress, researchers examined the antioxidant activity of polysaccharides from cucumber (Cucumis saticus L.) prepared by the hydrothermal method.
According to the tested assays in the chemical analysis of body fluids, the trichloroacetic acid (TCA) method showed a higher deproteinization percentage compared to other hydrothermal preparations.
In other words, the trichloroacetic acid (TCA) method demonstrated a little higher polysaccharide loss percentage due to the effect of the cucumber polysaccharide linkage by the β-glycosidic bonds.
According to the chemical constituent analysis, d-glucose, d-mannose, d-galactose, l-rhamnose, d-xylose, l-arabinose, d-glucuronic acid, and d-galacturonic acid worked synergistically in exerting scavenging ability against free radical superoxide anions.
Taken altogether, cucumber may be the best antioxidant whole food for the treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Preparation, deproteinization, characterisation, and antioxidant activity of polysaccharide from cucumber (Cucumis saticus L.) by Chen L1, Huang G2, Hu J. (PubMed)
(2) Effects of Heat Shock on Photosynthetic Properties, Antioxidant Enzyme Activity, and Downy Mildew of Cucumber (Cucumis sativus L.) by Ding X1,2, Jiang Y1, Hao T1, Jin H1, Zhang H1, He L1, Zhou Q1, Huang D2, Hui D3, Yu J. (PubMed)
(3) Role of Oxidative Stress in the Suppression of Immune Responses in Peripheral Blood Mononuclear Cells Exposed to Combustible Tobacco Product Preparation by Subhashini Arimilli,
1 Eckhardt Schmidt,2 Brad E. Damratoski,3 and G. L. Prasad. (PMC)
Antioxidants are stable molecules that inhibit oxidation produced either by the liver or from the consumption of antioxidant-rich foods.
In other words, antioxidants inhibit the unstable free radicals with a single electron in the outermost ring that facilitates the domino's reaction to cause oxidative stress.
Free radicals are unstable molecules existing everywhere in the environment and in the body. The air we breathe the food we eat and cellular metabolism are found to induce the production of free radicals.
Free radicals in moderate are necessary for the proper function of our body, such as free radical NO which is needed to relax the blood vessels. However, overexpression of free radicals can induce oxidative stress in the tissues and organs, leading to protein, lipid, and cellular DNA damage.
Overexpression of oxidative stress over time has been linked to the onset of chronic diseases, inclduing arthritis, cardiovascular disease, diabetes, and cancer.
In a healthy individual, antioxidant enzymes produced by the body are good enough to neutralize the levels of free radicals in the body. However, people with a weakened immune system may need an additional dietary source of antioxidants.
The most common risk factors associated with oxidative stress are antioxidant deficiency in the body caused by demographic, physical, lifestyle, or nutritional factors.
Some researchers suggested people who smoke may be at an increased risk of oxidative stress.
Dr. the lead scientist wrote, "Cigarette smoking is a major risk factor for several human diseases. Chronic inflammation, resulting from increased oxidative stress, has been suggested as a mechanism that contributes to the increased susceptibility of smokers to cancer and microbial infections".
, "Several studies have indicated greater levels of oxidative stress in cigarette smokers [31, 32], which is most likely attributed to the high concentration of ROS and nitrogen species (RNS) in cigarette smoke [33–36]. In addition, cigarette smoke has been associated with elevated ROS production by leukocytes in the airways of both acute and chronic smokers [37]".
The results strongly suggested, if you smoke, your risk of diseases associated with oxidative stress increased substantially, compared to those who don't.
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.
With an aim to find a natural compound that processes antioxidative stress, researchers examined the antioxidant activity of polysaccharides from cucumber (Cucumis saticus L.) prepared by the hydrothermal method.
According to the tested assays in the chemical analysis of body fluids, the trichloroacetic acid (TCA) method showed a higher deproteinization percentage compared to other hydrothermal preparations.
In other words, the trichloroacetic acid (TCA) method demonstrated a little higher polysaccharide loss percentage due to the effect of the cucumber polysaccharide linkage by the β-glycosidic bonds.
According to the chemical constituent analysis, d-glucose, d-mannose, d-galactose, l-rhamnose, d-xylose, l-arabinose, d-glucuronic acid, and d-galacturonic acid worked synergistically in exerting scavenging ability against free radical superoxide anions.
Taken altogether, cucumber may be the best antioxidant whole food for the treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Preparation, deproteinization, characterisation, and antioxidant activity of polysaccharide from cucumber (Cucumis saticus L.) by Chen L1, Huang G2, Hu J. (PubMed)
(2) Effects of Heat Shock on Photosynthetic Properties, Antioxidant Enzyme Activity, and Downy Mildew of Cucumber (Cucumis sativus L.) by Ding X1,2, Jiang Y1, Hao T1, Jin H1, Zhang H1, He L1, Zhou Q1, Huang D2, Hui D3, Yu J. (PubMed)
(3) Role of Oxidative Stress in the Suppression of Immune Responses in Peripheral Blood Mononuclear Cells Exposed to Combustible Tobacco Product Preparation by Subhashini Arimilli,
1 Eckhardt Schmidt,2 Brad E. Damratoski,3 and G. L. Prasad. (PMC)
#Eggplant Inhibits Receptors and Proteins Associated with the Onset of #Melanoma, Scientists Show
Kyle J. Norton
Eggplant may have a potential and substantial effect in reducing risk and treating melanoma, some scientists suggested.
Melanoma is a type of skin cancer characterized by irregular cell growth in the pigment-containing cell.
At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.
the exact causes of Melanoma are unknown. However, some researchers suggested that it is likely caused by a combination of factors.
Truly, certain risk factors, such as environmental and genetic factors, and exposure to ultraviolet (UV) radiation from the sun are associated with increased risk of the disease.
According to statistics, approximately 87,110 new cases of invasive melanoma were diagnosed in the U.S. in 2017.
The American Cancer Association singles out mutation of tumor suppressor genes such as CDKN2A and CDK4 that prevent them from doing their normal job of controlling cell growth is one of the major causes of melanoma.
If you experience some of the symptoms of sores that do not heal. Pigment, spreading redness or swelling, persistent itchiness, tenderness or pain,.... and bleeding from an existing mole. Please check with your doctor to rule out the possibility.
The 5 years survival rate of early diagnosis of Melanoma is about 97% and the 10-year survival is around 95%.
Eggplant is a species of S. melongena with deep purple color, belonging to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
In the evaluation of the effect of glycoalkaloids, the nitrogen-containing secondary plant metabolites found in numerous Solanaceous plants including eggplants in numbers of cancer cell lines, researchers showed that the isolated phytochemicals express a significant effect of inhibition of the process of the early stage of various types of cancer occurrence through inducing cancer cells apoptosis.
Further analysis, glycoalkaloid efficacy was attributed to the derived phytochemical compound solamargine inactivation of antioxidant activity against the formation of skin cancer through an expression of several biomarkers and signaling pathways.
In primary melanoma cell lines WM239 and WM115, the application of solamargine with half inhibitory concentration IC50 demonstrated a profound effect of inhibiting the growth of metastatic cancer cells and initiated apoptosis, through overexpression of lysosomal membrane permeabilization induced by leaky lysosomes during cell death, detected by lysosomal galectin puncta assay, without causing damage to normal and benign skin cells, namely, WM35.
Observation of the cellular necrosis also indicated that solamargine's anti-skin cancer effect was confirmed by the overexpression of cathepsin B which is considered a biomarker of malignant lesions and various cancers by triggering extrinsic mitochondrial death pathway function in the activated cellular apoptosis through the release of cytochrome c from mitochondria during the early stages of apoptosis and apoptotic tumor necrosis factor receptor-1(TNFR1).
Moreover, injection of the derivative solamargine also disrupted the intrinsic apoptosis pathway
through reduced expression of hILP/XIAP, an inhibitor of apoptotic cell death by blocking tumor cell proliferation.
Additional differentiation also suggested that the derivative solamargine also blocked the
expression of TNF receptor associated with tumor proliferation, survival, and differentiation to increase expression of proteins Bcl-xL, and Bcl2 that regulate anti-apoptosis, and anti-cell cycle arrest.
Unlike other phytochemicals such as green tea EGCG inhibited apoptosis through both intrinsic and extrinsic apoptosis pathways, eggplant derivative solamargine selectively triggered melanoma cancer cell death through only death receptors.
After taking account of other confounders, Dr, Sana S. said, " Solamargine showed high efficacy in vitro particularly against the vertical growth phase (forming a true tumor) melanoma cells".
Taken together, eggplant with abundant glycoalkaloids may be considered as a functional food to ameliorate the risk, progression, and treatment of melanoma. Intake of eggplant supplements should be taken with special care and only prescribed by experts.
However, additional data collection on large example size and multi-center studies performed with human consumption of the eggplant whole food during the course of the disease will be necessary to complete the picture of the night shape veggies anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes by Friedman M1(PubMed)
(1) Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway by Sana S. Al Sinani, Elsadig A. Eltayeb, Brenda L. Coomber, and Sirin A. Adham(PMC)
(3) Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway by Sana S. Al Sinani, Elsadig A Eltayeb, Brenda L. Coomber and Sirin A. Adham(Cancer cell international)
(4) Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications by Brahma N. Singh,1 Sharmila Shankar,2 and Rakesh K. Srivastava*(PMC)
Eggplant may have a potential and substantial effect in reducing risk and treating melanoma, some scientists suggested.
Melanoma is a type of skin cancer characterized by irregular cell growth in the pigment-containing cell.
At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.
the exact causes of Melanoma are unknown. However, some researchers suggested that it is likely caused by a combination of factors.
Truly, certain risk factors, such as environmental and genetic factors, and exposure to ultraviolet (UV) radiation from the sun are associated with increased risk of the disease.
According to statistics, approximately 87,110 new cases of invasive melanoma were diagnosed in the U.S. in 2017.
The American Cancer Association singles out mutation of tumor suppressor genes such as CDKN2A and CDK4 that prevent them from doing their normal job of controlling cell growth is one of the major causes of melanoma.
If you experience some of the symptoms of sores that do not heal. Pigment, spreading redness or swelling, persistent itchiness, tenderness or pain,.... and bleeding from an existing mole. Please check with your doctor to rule out the possibility.
The 5 years survival rate of early diagnosis of Melanoma is about 97% and the 10-year survival is around 95%.
Eggplant is a species of S. melongena with deep purple color, belonging to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
In the evaluation of the effect of glycoalkaloids, the nitrogen-containing secondary plant metabolites found in numerous Solanaceous plants including eggplants in numbers of cancer cell lines, researchers showed that the isolated phytochemicals express a significant effect of inhibition of the process of the early stage of various types of cancer occurrence through inducing cancer cells apoptosis.
Further analysis, glycoalkaloid efficacy was attributed to the derived phytochemical compound solamargine inactivation of antioxidant activity against the formation of skin cancer through an expression of several biomarkers and signaling pathways.
In primary melanoma cell lines WM239 and WM115, the application of solamargine with half inhibitory concentration IC50 demonstrated a profound effect of inhibiting the growth of metastatic cancer cells and initiated apoptosis, through overexpression of lysosomal membrane permeabilization induced by leaky lysosomes during cell death, detected by lysosomal galectin puncta assay, without causing damage to normal and benign skin cells, namely, WM35.
Observation of the cellular necrosis also indicated that solamargine's anti-skin cancer effect was confirmed by the overexpression of cathepsin B which is considered a biomarker of malignant lesions and various cancers by triggering extrinsic mitochondrial death pathway function in the activated cellular apoptosis through the release of cytochrome c from mitochondria during the early stages of apoptosis and apoptotic tumor necrosis factor receptor-1(TNFR1).
Moreover, injection of the derivative solamargine also disrupted the intrinsic apoptosis pathway
through reduced expression of hILP/XIAP, an inhibitor of apoptotic cell death by blocking tumor cell proliferation.
Additional differentiation also suggested that the derivative solamargine also blocked the
expression of TNF receptor associated with tumor proliferation, survival, and differentiation to increase expression of proteins Bcl-xL, and Bcl2 that regulate anti-apoptosis, and anti-cell cycle arrest.
Unlike other phytochemicals such as green tea EGCG inhibited apoptosis through both intrinsic and extrinsic apoptosis pathways, eggplant derivative solamargine selectively triggered melanoma cancer cell death through only death receptors.
After taking account of other confounders, Dr, Sana S. said, " Solamargine showed high efficacy in vitro particularly against the vertical growth phase (forming a true tumor) melanoma cells".
Taken together, eggplant with abundant glycoalkaloids may be considered as a functional food to ameliorate the risk, progression, and treatment of melanoma. Intake of eggplant supplements should be taken with special care and only prescribed by experts.
However, additional data collection on large example size and multi-center studies performed with human consumption of the eggplant whole food during the course of the disease will be necessary to complete the picture of the night shape veggies anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes by Friedman M1(PubMed)
(1) Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway by Sana S. Al Sinani, Elsadig A. Eltayeb, Brenda L. Coomber, and Sirin A. Adham(PMC)
(3) Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway by Sana S. Al Sinani, Elsadig A Eltayeb, Brenda L. Coomber and Sirin A. Adham(Cancer cell international)
(4) Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications by Brahma N. Singh,1 Sharmila Shankar,2 and Rakesh K. Srivastava*(PMC)
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