#Healthy Food Cucumber Inhibits Diseases Associated with Overexpression of Oxidativestress, AQccording to Studies

Kyle J. Norton

Antioxidants are stable molecules that inhibit oxidation produced either by the liver or from the consumption of antioxidant-rich foods.
In other words, antioxidants inhibit the unstable free radicals with a single electron in the outermost ring that facilitates the domino's reaction to cause oxidative stress.

Free radicals are unstable molecules existing everywhere in the environment and in the body. The air we breathe the food we eat and cellular metabolism are found to induce the production of free radicals.

Free radicals in moderate are necessary for the proper function of our body, such as free radical NO which is needed to relax the blood vessels. However, overexpression of free radicals can induce oxidative stress in the tissues and organs, leading to protein, lipid, and cellular DNA damage.


Overexpression of oxidative stress over time has been linked to the onset of chronic diseases, inclduing arthritis, cardiovascular disease, diabetes, and cancer.

In a healthy individual, antioxidant enzymes produced by the body are good enough to neutralize the levels of free radicals in the body. However, people with a weakened immune system may need an additional dietary source of antioxidants.

The most common risk factors associated with oxidative stress are antioxidant deficiency in the body caused by demographic, physical, lifestyle, or nutritional factors.

Some researchers suggested people who smoke may be at an increased risk of oxidative stress.

Dr. the lead scientist wrote, "Cigarette smoking is a major risk factor for several human diseases. Chronic inflammation, resulting from increased oxidative stress, has been suggested as a mechanism that contributes to the increased susceptibility of smokers to cancer and microbial infections".

, "Several studies have indicated greater levels of oxidative stress in cigarette smokers [31, 32], which is most likely attributed to the high concentration of ROS and nitrogen species (RNS) in cigarette smoke [33–36]. In addition, cigarette smoke has been associated with elevated ROS production by leukocytes in the airways of both acute and chronic smokers [37]".

The results strongly suggested, if you smoke, your risk of diseases associated with oxidative stress increased substantially, compared to those who don't.

The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.

With an aim to find a natural compound that processes antioxidative stress, researchers examined the antioxidant activity of polysaccharides from cucumber (Cucumis saticus L.) prepared by the hydrothermal method.

According to the tested assays in the chemical analysis of body fluids, the trichloroacetic acid (TCA) method showed a higher deproteinization percentage compared to other hydrothermal preparations.

In other words, the trichloroacetic acid (TCA) method demonstrated a little higher polysaccharide loss percentage due to the effect of the cucumber polysaccharide linkage by the β-glycosidic bonds.

According to the chemical constituent analysis, d-glucose, d-mannose, d-galactose, l-rhamnose, d-xylose, l-arabinose, d-glucuronic acid, and d-galacturonic acid worked synergistically in exerting scavenging ability against free radical superoxide anions.

Taken altogether, cucumber may be the best antioxidant whole food for the treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Preparation, deproteinization, characterisation, and antioxidant activity of polysaccharide from cucumber (Cucumis saticus L.) by Chen L1, Huang G2, Hu J. (PubMed)
(2) Effects of Heat Shock on Photosynthetic Properties, Antioxidant Enzyme Activity, and Downy Mildew of Cucumber (Cucumis sativus L.) by Ding X1,2, Jiang Y1, Hao T1, Jin H1, Zhang H1, He L1, Zhou Q1, Huang D2, Hui D3, Yu J. (PubMed)
(3) Role of Oxidative Stress in the Suppression of Immune Responses in Peripheral Blood Mononuclear Cells Exposed to Combustible Tobacco Product Preparation by Subhashini Arimilli,1 Eckhardt Schmidt,2 Brad E. Damratoski,3 and G. L. Prasad. (PMC)

#Eggplant Inhibits Receptors and Proteins Associated with the Onset of #Melanoma, Scientists Show

Kyle J. Norton

Eggplant may have a potential and substantial effect in reducing risk and treating melanoma, some scientists suggested.
Melanoma is a type of skin cancer characterized by irregular cell growth in the pigment-containing cell.

At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.

the exact causes of Melanoma are unknown. However, some researchers suggested that it is likely caused by a combination of factors.

Truly, certain risk factors, such as environmental and genetic factors, and exposure to ultraviolet (UV) radiation from the sun are associated with increased risk of the disease.

According to statistics, approximately 87,110 new cases of invasive melanoma were diagnosed in the U.S. in 2017.

The American Cancer Association singles out mutation of tumor suppressor genes such as CDKN2A and CDK4 that prevent them from doing their normal job of controlling cell growth is one of the major causes of melanoma.

If you experience some of the symptoms of sores that do not heal. Pigment, spreading redness or swelling, persistent itchiness, tenderness or pain,.... and bleeding from an existing mole. Please check with your doctor to rule out the possibility.


The 5 years survival rate of early diagnosis of Melanoma is about 97% and the 10-year survival is around 95%.

Eggplant is a species of S. melongena with deep purple color, belonging to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.

In the evaluation of the effect of glycoalkaloids, the nitrogen-containing secondary plant metabolites found in numerous Solanaceous plants including eggplants in numbers of cancer cell lines, researchers showed that the isolated phytochemicals express a significant effect of inhibition of the process of the early stage of various types of cancer occurrence through inducing cancer cells apoptosis.

Further analysis, glycoalkaloid efficacy was attributed to the derived phytochemical compound solamargine inactivation of antioxidant activity against the formation of skin cancer through an expression of several biomarkers and signaling pathways.

In primary melanoma cell lines WM239 and WM115, the application of solamargine with half inhibitory concentration IC50 demonstrated a profound effect of inhibiting the growth of metastatic cancer cells and initiated apoptosis, through overexpression of lysosomal membrane permeabilization induced by leaky lysosomes during cell death, detected by lysosomal galectin puncta assay, without causing damage to normal and benign skin cells, namely, WM35.


Observation of the cellular necrosis also indicated that solamargine's anti-skin cancer effect was confirmed by the overexpression of cathepsin B which is considered a biomarker of malignant lesions and various cancers by triggering extrinsic mitochondrial death pathway function in the activated cellular apoptosis through the release of cytochrome c from mitochondria during the early stages of apoptosis and apoptotic tumor necrosis factor receptor-1(TNFR1).

Moreover, injection of the derivative solamargine also disrupted the intrinsic apoptosis pathway
through reduced expression of hILP/XIAP, an inhibitor of apoptotic cell death by blocking tumor cell proliferation.

Additional differentiation also suggested that the derivative solamargine also blocked the
expression of TNF receptor associated with tumor proliferation, survival, and differentiation to increase expression of proteins Bcl-xL, and Bcl2 that regulate anti-apoptosis, and anti-cell cycle arrest.

Unlike other phytochemicals such as green tea EGCG inhibited apoptosis through both intrinsic and extrinsic apoptosis pathways, eggplant derivative solamargine selectively triggered melanoma cancer cell death through only death receptors.

After taking account of other confounders, Dr, Sana S. said, " Solamargine showed high efficacy in vitro particularly against the vertical growth phase (forming a true tumor) melanoma cells".

Taken together, eggplant with abundant glycoalkaloids may be considered as a functional food to ameliorate the risk, progression, and treatment of melanoma. Intake of eggplant supplements should be taken with special care and only prescribed by experts.

However, additional data collection on large example size and multi-center studies performed with human consumption of the eggplant whole food during the course of the disease will be necessary to complete the picture of the night shape veggies anti-cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes by Friedman M1(PubMed)
(1) Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway by Sana S. Al Sinani, Elsadig A. Eltayeb, Brenda L. Coomber, and Sirin A. Adham(PMC)
(3) Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway by Sana S. Al Sinani, Elsadig A Eltayeb, Brenda L. Coomber and Sirin A. Adham(Cancer cell international)
(4) Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications by Brahma N. Singh,1 Sharmila Shankar,2 and Rakesh K. Srivastava*(PMC)

#Phytochemical 3,3'-Diindolylmethane Inhibits Proteins Associated with #ColorectalCancer, Researchers Find

Kyle J. Norton

3,3'-Diindolylmethane or DIM may be used as a bioactive compound for the treatment of colorectal cancer with no side effects, according to studies.
Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells DNA.

According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.

The lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

Approximately, 140,000 cases of colorectal cancer were diagnosed in the US in 2018. Cancer also causes the death of over 50, 000 people, representing 8.3% of total cancer death.

Being overweight or obese. smoking, physical inactivity, excessive alcohol drinking, increased in age, family and personal history, and genetic preposition are some of the prevalent risks of the disease.

Some researchers suggested that an unhealthy diet such as the promotion of the Western diet over the past few decades may be one of the major causes of colorectal cancer.

Dr. Alan Moss, the lead scientist in the evaluation of the association between diet and colorectal cancer risk, wrote, "Studies that examined dietary factors and various cancers showed that one of the strongest associations is between CRC and meat consumption"

"Recently, global publicity was generated by the World Health Organization International Agency for Research on Cancer consensus statement regarding the increased risk of CRC with consumption of processed or red meat.4 The 2015 statement notes that processed meat is carcinogenic to humans and lists processed meat as a group 1 substance. Processed meats result from salting, smoking, fermenting, or curing the meat, and common examples include ham, bacon, and sausage".

The results clearly suggested that by changing your diet pattern from the Western diet to a traditional diet with high fruits and vegetables, your risk of colorectal can be reduced substantially.


3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, kale, etc.

Researchers concerned about the slow growth of colorectal cancer and the prognosis in colorectal cancer patients examined the effects of 3,3'-Diindolylmethane (DIM) on cyclin D1, which was aberrantly overexpressed in colorectal cancer cells and tumors.

Cyclin D1 is a protein needed for cellular proliferation in the G1 phase of the cell cycle.

Injection of DIM inhibited the cyclin D1 expression in colorectal cancer cells (CRC), without affecting the PPARγ expression and protease activity in regulating the process of cell differentiation.

Moreover, DIM inhibition of the cell cycle in the G1 phase of colorectal cancer cells (CRC) without alternating the cyclin D1 mRNA expression. The results suggested DIM modulated cyclin D1 expression at the translational level through some unknown mechanisms.

Dr. Zhang X and colleagues wrote in the final report, "The present study demonstrates that DIM downregulates cyclin D1 through triggering ER stress in human colorectal cancer cells".


In other words, DIM-induced cell cycle arrest of the colorectal cancer cells by modulating the G1 phase of the cell cycle.

Additionally, in order to reveal more information about the DIM anti-colorectal cancer activity, researchers elucidated the molecular mechanism of ATF3 induction by DIM in human CRC cells.

The DIM treatment induced apoptosis and induced ATF3 gene expression at protein and messenger RNA levels, involving the DNA repair of the damaged cells.

However, in colorectal cancer cells, deletion and point mutation of the ATF binding site (-23 to -16) abolished ATF3 promoter activation by DIM, leading to overexpression of ATF4 associated with the promotion of metabolic homeostasis and cancer cell survival

In other words, DIM stimulates ATF3 expression inducing apoptosis in human colorectal cells through inhibiting the ATF4-mediated pathway.

Taken together, 3,3'-Diindolylmethane derived from I3C may be considered a supplement for the prevention and combined with primary therapy for the treatment of colorectal cancer, pending the confirmation of a large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-diindolylmethane downregulates cyclin D1 through triggering endoplasmic reticulum stress in colorectal cancer cells by Zhang X1, Sukamporn P2, Zhang S3, Min KW4, Baek SJ. (PubMed)
(2) 3,3'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells by Lee SH1, Min KW, Zhang X, Baek SJ. (PubMed)
(3) The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations
Alan Moss, and Kumanan Nalankilli. (Gastroenterology)

#Phytochemical Betacyanins Inhibit #LiverStress Markers Inducing Liver Injury and Damage, Scientists Show

Kyle J. Norton

The liver is the largest internal organ that not only plays an essential role in filtering the blood from the digestive system before passing it to other parts of the body but also produces cholesterol, a waxy substance that aids digestion, builds cell membranes, and produces vitamin D and steroid hormones.
Liver disease is a class of medical conditions characterized by reducing partly or completely the function of the liver, including liver injury.

The most common symptoms of liver injury are totally depending on the severity of the injury that affects the liver function. In serious cases of liver injury, symptoms may include jaundice, pain in your upper right abdomen, abdominal swelling, gastrointestinal symptoms such as nausea and vomiting, disorientation or confusion, and sleepiness.

The most common causes of liver injury include

* Overdose of certain medications, especially acetaminophen overdose. Believe it or not, taking too much acetaminophen (Tylenol, others) is the most common cause of acute liver failure in the US.

* Overdose of some prescription medications, including antibiotics, nonsteroidal anti-inflammatory drugs, and anticonvulsants is also associated with liver injury.

* Overdose of herbal extracts such as green tea ECG

* Toxins
Exposure to toxic chemicals such as refrigerants and solvents for waxes and eating toxic food such as wild mushrooms may cause liver injury.

Out of many risk factors involved in liver injury, some researchers suggested alcohol intoxication, a condition of alcohol poisoning caused by excessively high levels of the recent drinking of ethanol in the blood (alcohol) may be one of the major culprits that cause the long-term injury to the liver.

Over time, excessive alcohol drinking can lead to fatty liver, alcoholic hepatitis, and chronic hepatitis with liver fibrosis or cirrhosis.

The Canadian Liver Association wrote, "When the liver has too much alcohol to handle, normal liver function may be interrupted leading to a chemical imbalance. If the liver is required to detoxify alcohol continuously, liver cells may be destroyed or altered resulting in fat deposits (fatty liver), and more seriously, either inflammation (alcoholic hepatitis), and/or permanent scarring (cirrhosis).

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a potential compound for the prevention of liver injury, researchers examined the protective effect of betanin, a chemical compound found in the class of betacyanins on the liver.

In fish pretreated with 1, 2, and 4 % betanin in fodder throughout the experiment for 20 days before intraperitoneally injected with 20 % (v/v in peanut oil) CCl4 at a volume of 0.5 mL/kg body weight, researchers showed that* Injection of CCl4 induced liver injury by promoting the expression of liver CYP2E1 which has been found to increase in a patient with liver disease, and oxidative stress.

* Elevated serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT) activities and liver histological damage in CCl4 fish were also decreased in the treatment group.

More precisely, compared with the CCl4 control group, the betanin-treated groups exhibited reduced CYP2E1 activity, decreased malondialdehyde level, and increased liver antioxidative capacity (increased glutathione level and superoxide dismutase and catalase activities).

In other words, all parameters associated with liver injury in the CCl4 group are inhibited by the administration of betanin.

Based on the findings, researchers said, " In conclusion, betanin attenuates CCl4-induced liver damage in common carp. Moreover, the inhibition of CYP2E1 activity and oxidative stress may have significant roles in the protective effect of betanin".

Taken together, betacyanins processed abundantly bioactive compound betanin may be considered a remedy for the prevention and treatment of liver injury, pending the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Betanin attenuates carbon tetrachloride (CCl4)-induced liver injury in common carp (Cyprinus carpio L.) by Han J1, Gao C, Yang S, Wang J, Tan D. (PubMed)
(2) Opuntia ficus indica (L.) Mill. fruit juice protects liver from carbon tetrachloride-induced injury by Galati EM1, Mondello MR, Lauriano ER, Taviano MF, Galluzzo M, Miceli N.(PubMed)
(3) Alcohol-Related Complications by the Canadian Liver Association

#Allicin Acts as Cysteine Protease Inhibitor in the Prevention and Treatment of Parasite-Inhection , Scientists Say

Kyle J. Norton

Scientists may have found a natural ingredient with a similar effect as that of antibiotics for the treatment of malaria with no side effects, according to studies.
Malaria is a mosquito-borne infectious disease caused by parasitic protozoans.

According to the statistics, malaria is one of the most common diseases in Nigeria, affecting over 97% of Nigeria's population. There are an estimated 100 million malaria cases with over 300,000 deaths per year.

Symptoms of malaria tend to occur in cycles, which correspond to the life cycle of the parasite. The most common symptoms include headaches, fatigue, muscle aches, and gastrointestinal discomforts including diarrhea.

In severe cases, patients with malaria may also experience symptoms of shortness of breath caused by fluid in the lungs and expanded abdomen caused by enlarged spleen hypoglycemia and liver diseases such as jaundice and low blood glucose.

Immune deficiency, pregnant women, and newborn babies are prone to the disease if they are bitten by an infected mosquito.

However, some researchers suggested that where you live may be one of the major risks for the disease onset.
Dr. Wulung Hanandita, the lead scientist in the concern of geography and social distribution of malaria in Indonesian, wrote, "Rural Papuans, as well as those who live in poor, densely forested, lowland districts, are at a higher risk of infection than their counterparts. We also find age and gender differentials in malaria prevalence, if only to a small degree".

These results clearly suggested that if you are poor, and live in densely forested, lowland districts (away from the urban world), you are at an increased risk of malaria.

Allicin is a phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in onion and garlic.

In the concern of widespread malaria infection in the third world where antibiotics are scarce, researchers urgently looked into allicin, the major biologically active component of garlic which has been found to exert a similar effect as that of Western medicine with no side effects.

In protozoan parasites including Plasmodium, injection of allicin reduced parasitemia and prolonged survival of the host in a dose-dependent manner by improving the host immune responses.

During the experiment, researchers discovered the efficacy of allicin against the tested parasites was attributed to the bioactive compound in stimulating the production of pro-inflammatory cytokines.

The numbers of white blood cells such as macrophages were significantly higher in allicin-treated mice.

The promotion of proinflammatory cytokines and immune response by allicin did reduce the function of anti-inflammatory cytokines during the course of the test.
In other words, allicin protects the host against P. yoelii 17XL through enhancement of the host's innate and adaptive immune responses.


Furthermore, examining the effect of allicin on sporozoites, researchers found that at low concentrations, allicin was not toxic to either sporozoites or mammalian cells.

In vitro, at these low concentrations, allicin inhibited the circumsporozoite protein (CSP) processing and prevented sporozoite invasion of host cells.

Mice injected with allicin had decreased Plasmodium infections and prevented malaria infection compared to controls.

Moreover, a 4-day regimen of allicin administered either orally or intravenously significantly decreased parasitemias and increased the survival of infected mice by 10 days.

Dr. Coppi A the lead scientist on the final reports said, "These experiments demonstrate that the same cysteine protease inhibitor can target two different life cycle stages in the vertebrate host".

Taken together, the results strongly suggested that phytochemical allicin may be considered an alternative antibiotic for the prevention and combined with the primary medicine for the treatment of malaria induced by parasite infection.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Allicin enhances host pro-inflammatory immune responses and protects against acute murine malaria infection by Feng Y, Zhu X, Wang Q, Jiang Y, Shang H, Cui L, Cao Y.(PubMed)
(2) Antimalarial activity of allicin, a biologically active compound from garlic cloves by Coppi A, Cabinian M, Mirelman D, Sinnis P.(PubMed)
(3) Geography and social distribution of malaria in Indonesian Papua: a cross-sectional study by Wulung Hanandita and Gindo Tampubolon. (PMC)

#Anacardicacids Process Anti-Antiproliferative and Cytotoxic Effect on Pituitary Adenoma Cells, Researchers Show

Kyle J. Norton

Scientists may have found a natural ingredient for the prevention and treatment of pituitary adenomas with no side effects, according to studies.
Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.

Pituitary adenomas are noncancerous tumors that occur in the pituitary gland.

A pituitary tumor has a negative and strong implication for the production of the thyroid-stimulating hormone, leading to a rare case of hyperthyroidism which normally induces unintentional weight loss.

Most cases of pituitary adenomas start in the cell of the inner lining of the tissue of the pituitary gland, due to the alternation of DNA. The tumor is well contained in the gland with no tendency to spread.

At the early stage, patients with benign tumors do not experience any symptoms. However, when the tumor grows larger, it may suppress the healthy tissue in the gland or nearby nerve cells, leading to symptoms of headache, vision loss, and severe pain.

Epidemiological studies suggested that depending on the stage of the pituitary tumor, patients can experience hormone overproduction and hormone deficiency, leading to certain hormonal-related diseases.

Depending on the size of the tumor and its effect on the patient's health, surgery may be the only option, if the tumor is pressing on the optic nerves or overproducing certain hormones.

In the concern of morbidity and complication of therapy in patients with pituitary adenomas, researchers examined the effect of anacardic acids, a natural histone acetyltransferase inhibitor, on pituitary adenoma cells.

Epidemiological studies suggested that the progression of the benign pituitary tumor, if not treated, is a prevalent risk factor for the onset of malignant tumor pathogenesis.

Injection of anacardic acid exerted a significant anti-antiproliferative and cytotoxic effect on pituitary adenoma cells.

According to the flow cytometry and Western blotting assays, anacardic acid inhibition of the tested cell line was associated with an increase the functions of the protein involved in a number of cellular processes in programming cell death and through cell cycle arrest on the G1 phase.

The marker used to detect cancer cell apoptosis, Annexin A5 (or annexin V), a cellular protein in the annexin group also increased after injecting the cancer cell with Anacardic acids.


In vitro and in vivo researchers found that administration of a pan-caspase inhibitor that irreversibly inhibits enzymatic function and is effective in blocking apoptosis in a variety of cell types under normal conditions has failed to reverse anacardic acid-induced cell death.


These results suggested that the bioactive induced cancer cell apoptosis through a possible nonclassical mechanism.

Furthermore, Anacardic acid the anti-cancer effect also suppressed the function of the survivin protein functions to exhibit negative regulation of apoptosis or programmed cell death and X-linked inhibitor of apoptosis protein (XIAP) associated with the anti-apoptotic function.

More importantly, the bioactive compound was found to deactivate the antiapoptotic proteins associated with cellular survival and radioresistance and radiosensitized pituitary adenoma cells.

The findings indicated that the chemical compound inhibited the onset and progression of pituitary adenomas by promoting cell cycle arrest, cancer apoptosis, and programming cell death through some known and unknown mechanisms.

Taken all together, Anacardic acids may be used for the prevention and treatment of pituitary adenomas with no side effects, pending to the result of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) Anacardic acid induces caspase-independent apoptosis and radiosensitizes pituitary adenoma cells by Sukumari-Ramesh S, Singh N, Jensen MA, Dhandapani KM, Vender JR.(PubMed)

#Phytochemical Lycopene Detoxes the Liver Against Toxicity through Its Antioxidant Activity, Researchers Say

Kyle J. Norton

Human toxicity is a general term that refers to any substance that causes harm to human health if inhaled, ingested, or absorbed through the skin.
Liver toxicity is a process that causes liver damage by reducing the function of the liver.

Liver oxidative stress caused by a toxic substance such as an overdose of the supplement has been found to constitute most cases of acute liver damage.

The liver is the largest internal organ that not only filters the blood from the digestive system before passing it to other parts of the body but also plays a critical role in the production of cholesterol, a waxy substance that aids digestion, builds cell membranes, and produces vitamin D and steroid hormones.

Liver stress is a condition in which the function of the liver is partly reduced. Hepatic stress can be observed by the levels of liver stress-makers, including transaminases aspartate transaminase (AST) and alanine transaminase (ALT).


Abnormal high levels of transaminases aspartate transaminase (AST) and alanine transaminase (ALT) are early indications of liver damage or injury.

Epidemiologically, drugs that induce liver injury are nonsteroidal anti-inflammatory drugs (NSAIDs), anti-infective drugs (anti-tubercular drugs), anti-cancer drugs, hormonal drugs, immunosuppressive agents, and sedative and neuropsychiatric drugs.

Acetaminophen according to study is the most form of medication that implicates drug-induced liver injury

However, antibiotics are the class of drugs that cause liver toxicity most commonly

Conventionally, treatment of liver toxicity is totally depending on the types of inducers, including
* Management of drug-induced liver injury by discontinuing the suspected drug.

* Acetaminophen poisoning is treated by antidote N-acetylcysteine.

* Glucocorticoids are used for the treatment of immune-mediated drug-induced liver injury.
And,
* Intravenous N- N-acetylcysteine is used for the treatment of non-acetaminophen-related acute liver failure


Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

In finding a potential compound for the prevention of liver injury, researchers investigated the potential oxidative damage of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in hepatic microsomal fractions in an animal model.

The study included rat liver microsomes that were divided into four groups.
* Group I served as a control and is incubated with vehicle (toluene).

* Groups II and IV incubated with 20 µM lycopene for 1 h before further incubating; and

* Groups III and IV with 15 nM of TCDD for a further 1 h.

Based on the tested analysis, groups treated by TCDD showed a significant increase in liver oxidative stress observed by increasing levels of Hydrogen peroxide (H2O2) production, lipid peroxidation (LPO),

Protein carbonyl content and activities of uridine 5'-diphospho-glucuronyltransferase (UDPGT) and P450 associated with liver damage also increased substantially in the TCDD treatment groups.

Furthermore, the activity of antioxidant enzymes superoxide dismutase, glutathione peroxidase, catalase, glutathione-S-transferase, and glutathione reductase and the microsomal thiol content produced by the rat liver microsomes were significantly decreased in the TCDD treament groups.

Lycopene treatment group IV not only normalized the activities of the enzymes, thiol and carbonyl content but also significantly reduced LPO and H2O2 production.

These results suggested that TCDD induced liver toxicity by increasing the levels of free radicals and decreasing the antioxidant activity in rat liver microsomes.

Based on the findings, researchers concluded, "TCDD induces significant oxidative stress in liver microsomes as manifested by increased LPO, H2O2 production, protein carbonyl content and activities of UDPGT and P450 and decreased antioxidant enzymes activities and thiol content".

Taken together, lycopene found in tomatoes may be considered a supplement for the prevention and treatment of liver toxicity, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene: Hepatoprotective and Antioxidant Effects toward Bisphenol A-Induced Toxicity in Female Wistar Rats by Abdel-Rahman HG1, Abdelrazek HMA2, Zeidan DW3, Mohamed RM4, Abdelazim AM. (PubMed)
(2) Ameliorative effect of lycopene against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced rat liver microsomal toxicity: an in vitro study by Aly HA1, El-Shitany NA2, El-Beshbishy HA3, Ashour OM. (PubMed)
(3) Liver Toxicity by Anam Bashir, and Dhruv Mehta. (NCBI)