Kyle J. Norton
Cardiomyocyte hypertrophy is a medical condition of the thickening of the heart muscle, leading to reduced function of the heart in pumping blood throughout the body.
The heart muscles make up the bulk of the heart’s mass and control the heartbeat with high contractile strength and endurance.
Cardiac muscle also has a unique function to regulate heart performance by spreading electrochemical signals to all cells in the heart.
Damage to the heart muscle has been found to induce blood vessel diseases, such as coronary artery disease; and heart rhythm problems (arrhythmias).
In some cases, head muscle-associated diseases also are found in patients with congenital heart defects.
Symptoms include breathlessness with exertion or at rest, legs, ankles, and feet swelling. persistent fatigue, dizziness, lightheadedness, and fainting, particularly, in the symptoms of irregular heartbeats.
Conventionally, treatment of diseases associated with cardiomyocyte hypertrophy depending on the types of heart disease, includes lowering blood pressure medication such as ACE inhibitors; lowering the heart rate, such as beta-blockers, normalizing heart beating, and balancing electrolytes in the body.
Making a healthy lifestyle change and moderate exercise may also be recommended by your doctor.
Out of many risk factors associated with the onset of cardiomyocyte hypertrophy, smoking can be considered one of the major prevalent factors.
Dr. Moustafa Al Hariri,, the lead scientist wrote, "Cardiovascular diseases are the leading causes of morbidity and mortality worldwide. Cigarette smoking remains a global health epidemic with associated detrimental effects on the cardiovascular system".
, "(According to the results of the study) cigarette smoking exposure is associated with significant cardiovascular pathology such as cardiac hypertrophy, inflammation, pro-fibrotic, and atherogenic markers and aortic calcification in an animal model as assessed 1-month post-exposure".
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
In the urgency to discover a natural compound for the treatment of heart disease, researchers examined alliin, the main constituent found in garlic in the prevention of cardiomyocyte hypertrophy and cell death.
The study included adult rat cardiomyocytes induced hypertrophy by Norepinephrine (NE) pretreated with garlic skin and flesh extracts.
Before the treatment of garlic skin and flesh extracts, exposure of cardiomyocytes to NE induced an increase in cell size and cell death, an indication of cardiomyocyte hypertrophy.
This increase in cardiomyocyte hypertrophy and cell death was prevented significantly upon treatment with garlic skin and flesh extracts.
Furthermore, the increased cell apoptosis and oxidative stress in cardiomyocytes by norepinephrine were also inhibited by the presence of the extract.
In the constituent analysis, the efficacy of anti cardiomyocyte hypertrophy and cell death may be attributed to the concentration of allicin and alliin.
In order to reveal more information about the alliin anti cardiomyocyte hypertrophy, the team from the SASTRA-Deemed University investigated the preventive effect of S-allyl cysteine sulfoxide (SACS) in isoproterenol (ISO)-induced myocardial ischemia in male Wistar rats.
The selected rats were pretreated with SACS (40 and 80 mg kg(-1) body-weight) for 5 weeks. After the treatment period, followed by the ISO (150 mg kg(-1) body weight) was administered subcutaneously at intervals of 24 h for 2 days.
According to the tested assays, oral pretreatment with SACS significantly decreased the activity of HMG CoA reductase associated with the production of cholesterol and other isoprenoids and significantly increased the activity of LCAT involved in converting free cholesterol into cholesteryl ester in ISO-induced rats.
Futhermore, pretreatment with SACS significantly decreased the levels of lipid peroxides in ISO-treated rats.
From a concentration perspective, a dose of 80 mg kg(-1) body weight was more effective in normalizing all the biochemical parameters compared to the dose of 40 mg kg(-1) body weight.
In other words, alliin inhibited the onset of myocardial ischemia caused by isoproterenol (ISO) in a dose-dependent manner, in vitro and in vivo.
Taken altogether, alliin may be considered a supplement for the prevention and treatment of cardiomyocyte hypertrophy, pending the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
Garlic extracts prevent oxidative stress, hypertrophy and apoptosis in cardiomyocytes: a role for nitric oxide and hydrogen sulfide by Louis XL1, Murphy R, Thandapilly SJ, Yu L, Netticadan T. (PubMed)
(2) Preventive effect of S-allyl cysteine sulfoxide (alliin) on cardiac marker enzymes and lipids in isoproterenol-induced myocardial injury by Sangeetha T1, Darlin Quine S. (PubMed)
(3) Cigarette Smoking-Induced Cardiac Hypertrophy, Vascular Inflammation and Injury Are Attenuated by Antioxidant Supplementation in an Animal Model by Moustafa Al Hariri,1,† Kazem Zibara,2,3,† Wissam Farhat,2,† Yasmine Hashem,4Nadia Soudani,4,5 Farah Al Ibrahim,3 Eva Hamade,2,3 Asad Zeidan,4 Ahmad Husari,6,* andFiras Kobeissy. (PMC)
Sunday, 29 October 2023
#Phytochemical #Betanin Inhibits Pathological Damage and Markers Associated with Liver Toxicity, Researchers Suggest
Kyle J. Norton
Liver toxicity is a condition in which the liver is damaged due to an overdose of medicine or harmful substances.
In the US, the most common causes of liver toxicity are the results of the most common drug-induced liver injury including overdoses of acetaminophen.
Believe it or not, antibiotics are the class of drugs most commonly causing liver toxicity.
The liver is the largest internal organ that processes the function to filter out blood from the digestive tract before passing it to other parts of the body. Furthermore, the liver also produces cholesterol in a moderate amount which aids the digestive system in absorbing nutrients builds a strong cell wall, and produces vitamin D and steroid hormones.
However, overexpression in most cases caused by injection of fat from the dietary source can lead to plaque accumulating on the wall of the artery, leading to an increased risk of heart disease and stroke.
Liver damage can be hepatocellular caused by direct hepatotoxicity, or innate and adaptive immune responses, and cholestatic caused most commonly by the drug or the drug metabolite, or mixed.
Liver damage can lead to reduced function of liver hepatobiliary transporter systems that affect the bile formation and secretion of cholephilic substances and xenobiotics.
Acute liver toxicity can be cured if the cause is found. However, damage to the liver in some cases can be permanent, inducing the formation of irreversible scarring of liver tissue.
The most common symptoms of liver toxicity are jaundice, persistent itching, and abdominal pain.
Some patients may also experience symptoms of pain in the upper right portion of the abdomen fatigue, loss of appetite accompanied by gastrointestinal discomforts.
If you have some of the above symptoms, please check with your doctor to rule out the possibility.
Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential ingredient for the prevention of liver injury, researchers examined the protective effect of betanin (from natural pigments) against paraquat-induced liver injury in Sprague-Dawley rats.
Selected rats induced liver toxicity intraperitoneally, were randomly divided into four groups: a control group, a paraquat group, and two groups that received betanin at doses of 25 and 100mg/kg/day three days before and two days after they were administered paraquat.
Rats injected with paraquat showed a significant liver injury observed by the elevated levels of liver oxidative stress markers including serum aspartate aminotransferase and alanine aminotransferase levels.
Furthermore tested rats also led to oxidative stress, liver toxicity observed by the increased levels of increase of cytochrome P450 3A2 mRNA expression and histological changes of mitochondria, including mitochondrial damage, indicated by mitochondrial membrane swelling.
Moreover, the levels of protein-associated liver cell death also increased compared to the reduced mitochondrial cytochrome C due to cytochrome c release.
Administration of betanin inhibited the pathological damage and all of the above-mentioned markers.
In other words, paraquat rats treated with betanin showed lesser pathological damage compared to those of the untreated groups.
Based on the findings, researchers wrote, " Betanin had a protective effect against paraquat-induced liver damage in rats".
In order to reveal additional information about betanin anti-liver toxicity, scientists assessed whether betanin (a natural pigment) is able to mitigate some OPs-induced hepatotoxicity in primary rat hepatocytes.
According to the tested assays from observation of mitochondrial depolarization as toxicity markers., administration of betanin (25μM) in tested rats significantly increased cell viability, inhibited the ROS formation and LPO, restored the levels of the cellular antioxidant glutathione (GSH) produced by the host.
Furthermore, followed by the treatment of chlorpyrifos (CPF) (300μM), diazinon (DZN) (600μM) and dichlrovos (DDVP) (400μM) treatment, betanin exerted strongly mitochondrial protection against liver toxicity.
Collectively, Dr. Ahmadian E, the lead scientist said, "potential protective role of betanin in OPs-induced hepatotoxicity in which the mechanism appears to be inhibition of ROS formation and mitochondrial protection".
Taken altogether, betanin may be considered a supplement for the prevention and treatment of liver toxicity, pending the confirmation of a larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin attenuates paraquat-induced liver toxicity through a mitochondrial pathway by Han J1, Zhang Z2, Yang S2, Wang J2, Yang X2, Tan D. (PubMhttps://www.ncbi.nlm.nih.gov/pubmed/24799198ed)
(2) Betanin reduces organophosphate induced cytotoxicity in primary hepatocyte via an anti-oxidative and mitochondrial dependent pathway by Ahmadian E1, Khosroushahi AY2, Eghbal MA, Eftekhari A. (PubMed)
Liver toxicity is a condition in which the liver is damaged due to an overdose of medicine or harmful substances.
In the US, the most common causes of liver toxicity are the results of the most common drug-induced liver injury including overdoses of acetaminophen.
Believe it or not, antibiotics are the class of drugs most commonly causing liver toxicity.
The liver is the largest internal organ that processes the function to filter out blood from the digestive tract before passing it to other parts of the body. Furthermore, the liver also produces cholesterol in a moderate amount which aids the digestive system in absorbing nutrients builds a strong cell wall, and produces vitamin D and steroid hormones.
However, overexpression in most cases caused by injection of fat from the dietary source can lead to plaque accumulating on the wall of the artery, leading to an increased risk of heart disease and stroke.
Liver damage can be hepatocellular caused by direct hepatotoxicity, or innate and adaptive immune responses, and cholestatic caused most commonly by the drug or the drug metabolite, or mixed.
Liver damage can lead to reduced function of liver hepatobiliary transporter systems that affect the bile formation and secretion of cholephilic substances and xenobiotics.
Acute liver toxicity can be cured if the cause is found. However, damage to the liver in some cases can be permanent, inducing the formation of irreversible scarring of liver tissue.
The most common symptoms of liver toxicity are jaundice, persistent itching, and abdominal pain.
Some patients may also experience symptoms of pain in the upper right portion of the abdomen fatigue, loss of appetite accompanied by gastrointestinal discomforts.
If you have some of the above symptoms, please check with your doctor to rule out the possibility.
Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential ingredient for the prevention of liver injury, researchers examined the protective effect of betanin (from natural pigments) against paraquat-induced liver injury in Sprague-Dawley rats.
Selected rats induced liver toxicity intraperitoneally, were randomly divided into four groups: a control group, a paraquat group, and two groups that received betanin at doses of 25 and 100mg/kg/day three days before and two days after they were administered paraquat.
Rats injected with paraquat showed a significant liver injury observed by the elevated levels of liver oxidative stress markers including serum aspartate aminotransferase and alanine aminotransferase levels.
Furthermore tested rats also led to oxidative stress, liver toxicity observed by the increased levels of increase of cytochrome P450 3A2 mRNA expression and histological changes of mitochondria, including mitochondrial damage, indicated by mitochondrial membrane swelling.
Moreover, the levels of protein-associated liver cell death also increased compared to the reduced mitochondrial cytochrome C due to cytochrome c release.
Administration of betanin inhibited the pathological damage and all of the above-mentioned markers.
In other words, paraquat rats treated with betanin showed lesser pathological damage compared to those of the untreated groups.
Based on the findings, researchers wrote, " Betanin had a protective effect against paraquat-induced liver damage in rats".
In order to reveal additional information about betanin anti-liver toxicity, scientists assessed whether betanin (a natural pigment) is able to mitigate some OPs-induced hepatotoxicity in primary rat hepatocytes.
According to the tested assays from observation of mitochondrial depolarization as toxicity markers., administration of betanin (25μM) in tested rats significantly increased cell viability, inhibited the ROS formation and LPO, restored the levels of the cellular antioxidant glutathione (GSH) produced by the host.
Furthermore, followed by the treatment of chlorpyrifos (CPF) (300μM), diazinon (DZN) (600μM) and dichlrovos (DDVP) (400μM) treatment, betanin exerted strongly mitochondrial protection against liver toxicity.
Collectively, Dr. Ahmadian E, the lead scientist said, "potential protective role of betanin in OPs-induced hepatotoxicity in which the mechanism appears to be inhibition of ROS formation and mitochondrial protection".
Taken altogether, betanin may be considered a supplement for the prevention and treatment of liver toxicity, pending the confirmation of a larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin attenuates paraquat-induced liver toxicity through a mitochondrial pathway by Han J1, Zhang Z2, Yang S2, Wang J2, Yang X2, Tan D. (PubMhttps://www.ncbi.nlm.nih.gov/pubmed/24799198ed)
(2) Betanin reduces organophosphate induced cytotoxicity in primary hepatocyte via an anti-oxidative and mitochondrial dependent pathway by Ahmadian E1, Khosroushahi AY2, Eghbal MA, Eftekhari A. (PubMed)
#Topical Formulation, Containing Phenylalanine, Cucumis Melo #Extract and Acetylcysteine Inhibits the Onset of #Vitiligo
Kyle J. Norton
Vitiligo is a condition of skin discoloration caused by the destruction of pigment cells and melanocytes of the skin.
The condition, in most cases, is localized. However, in some patients, the disease also can affect several different areas of the body.
Symptoms of vitiligo are associated with the loss of skin color, or white, and patches of skin.
The exact cause of vitiligo is unknown, however, some researchers suggest that the disease may be caused by an immune overreaction that mistakenly attacks and destroys certain cells within the body.
Epidemiologically, people in the younger age group before the age of 40 are at most risk of vitiligo.
According to the statistics, over 50% of vitiligo is found in patients who are 20 and younger.
The condition has been found to induce emotional and psychological issues in patients, even if the condition does not cause pain or health problems.
As of today, researchers do not know how to prevent disease onset. Most medications for the treatment of vitiligo including creams that control inflammation, combine psoralen and light therapy focusing on reducing the severity of the condition and improving the quality of life.
If all noninvasive treatments fail, surgery may be necessary.
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In finding a natural compound for the treatment of vitiligo, researchers examined the curcumin effect on the pigment cells of the skin, melanocytes.
Injection of Cucumis melo extract showed to exhibit the production of antioxidants by the host in blocking the effect of free radicals in the induction of skin oxidative stress.
Topical preparation, containing Cucumis melo superoxide dismutase (SOD) and catalase, demonstrated a potential effect in the treatment of vitiligo.
Natural UV or artificial narrowband UVB treatment or phototherapy displayed significant protection against pigment damage, similar to those of turmeric topical preparation.
Additionally, the topical gel according to the repigmentation rate recorded exerted a similar effect compared to the patients treated only with phototherapy with adverse effects.
Moreover, the topical formulation, containing phenylalanine, Cucumis melo extract, and acetylcysteine showed a more promising result combined with nb - UVB target phototherapy.
Based on the findings, turmeric used along with or combined with other conventional medicine may be considered remedies for the prevention and treatment of vitiligo pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Herbal Compounds for the Treatment of Vitiligo: A Review by Serena Gianfaldoni,1,* Uwe Wollina,2 Michael Tirant,3 Georgi Tchernev,4 Jacopo Lotti,5Francesca Satolli,6 Miriam Rovesti,6 Katlein França,7 and Torello Lotti. (PMC)
Vitiligo is a condition of skin discoloration caused by the destruction of pigment cells and melanocytes of the skin.
The condition, in most cases, is localized. However, in some patients, the disease also can affect several different areas of the body.
Symptoms of vitiligo are associated with the loss of skin color, or white, and patches of skin.
The exact cause of vitiligo is unknown, however, some researchers suggest that the disease may be caused by an immune overreaction that mistakenly attacks and destroys certain cells within the body.
Epidemiologically, people in the younger age group before the age of 40 are at most risk of vitiligo.
According to the statistics, over 50% of vitiligo is found in patients who are 20 and younger.
The condition has been found to induce emotional and psychological issues in patients, even if the condition does not cause pain or health problems.
As of today, researchers do not know how to prevent disease onset. Most medications for the treatment of vitiligo including creams that control inflammation, combine psoralen and light therapy focusing on reducing the severity of the condition and improving the quality of life.
If all noninvasive treatments fail, surgery may be necessary.
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In finding a natural compound for the treatment of vitiligo, researchers examined the curcumin effect on the pigment cells of the skin, melanocytes.
Injection of Cucumis melo extract showed to exhibit the production of antioxidants by the host in blocking the effect of free radicals in the induction of skin oxidative stress.
Topical preparation, containing Cucumis melo superoxide dismutase (SOD) and catalase, demonstrated a potential effect in the treatment of vitiligo.
Natural UV or artificial narrowband UVB treatment or phototherapy displayed significant protection against pigment damage, similar to those of turmeric topical preparation.
Additionally, the topical gel according to the repigmentation rate recorded exerted a similar effect compared to the patients treated only with phototherapy with adverse effects.
Moreover, the topical formulation, containing phenylalanine, Cucumis melo extract, and acetylcysteine showed a more promising result combined with nb - UVB target phototherapy.
Based on the findings, turmeric used along with or combined with other conventional medicine may be considered remedies for the prevention and treatment of vitiligo pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Herbal Compounds for the Treatment of Vitiligo: A Review by Serena Gianfaldoni,1,* Uwe Wollina,2 Michael Tirant,3 Georgi Tchernev,4 Jacopo Lotti,5Francesca Satolli,6 Miriam Rovesti,6 Katlein França,7 and Torello Lotti. (PMC)
#Herbal #Bilberry's Extracts Reduce the Risk of Vascular Disease, Researchers Show
Kyle J. Norton
Vasoprotection is the action in which substances including herbal and natural remedies are used to protect the integrity of the blood vessels.
Blood vessels are the tubular structure including a vein, artery, or capillary which carries the blood through the tissues and organs pumped by the heart.
There are 3 main types of blood vessel
* Arteries that deliver oxygen-rich blood from the heart to the tissues and organs of the body. Damage of arteries is found to induce coronary artery disease caused by narrowing or blockage of the coronary arteries due to plaques accumulated on the arterial wall.
* Veins that carry blood toward the heart. Chronic venous insufficiency (CVI) is a common condition associated with a disease of the veins that affects up to 20 percent of adults.
* Capillaries (the smallest blood vessels) have been found to induce systemic capillary leak syndrome (SCLS) is a rare acquired disorder.
Some researchers suggested that following a healthy diet accompanied by moderate exercise may have a strong impact on the blood vessels' integrity.
Dr. Hanrui Zhang said, "Accumulating evidence suggests that inflammatory cytokine tumor necrosis factor-alpha (TNFα) plays a pivotal role in the dysregulation of macrovascular and microvascular function".
And, "Dietary supplements and exercise training decrease TNFαproduction and ameliorate TNFα-mediated pathological changes in vasculature. Thus, the inhibitory effects of dietary supplements and physical exercise on TNFα production and TNFα signaling may contribute to their vasoprotective properties".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
On finding a natural ingredient that processes vasoactive and vasoprotective properties, researchers examined the effects of anthocyanin-rich extracts prepared from chokeberry (Ck), bilberry (B), or elderberry (E). on reactive oxygen species (ROS) play a critical role in the impairment of nitric oxide-mediated vascular functions.
In Coronary arterial rings isolated from 64 pigs and incubated in sterile tissue culture media overnight, Ck and B, but not E, produced dose- and endothelium-dependent vasorelaxation.
In coronary vascular tone, endothelium-dependent vasorelaxation by other factors was not affected by exposure of rings to any extract at 0.05 mg total anthocyanins per liter for 5 or 30 min.
Furthermore, anthocyanin-enhanced extracts produce endothelium-dependent relaxation in porcine coronary arteries.
However, high doses of B exerted a significant protective effect against the alternation of coronary arteries induced by ROS with no effect on vasorelaxation to endogenous or exogenous NO.
Based on the findings, researchers wrote, "These results suggest that such extracts could have significant beneficial effects in vascular disease".
Taken together, bilberry-processed abundantly bioactive compound anthocyanin may be considered a functioning remedy for the prevention and treatment of vascular disease, pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts by Bell DR1, Gochenaur K. (PubMed)
(2) Vasoprotection by Dietary Supplements and Exercise: Role of TNFα Signaling by Hanrui Zhang* and Cuihua Zhang. (PMC)
Vasoprotection is the action in which substances including herbal and natural remedies are used to protect the integrity of the blood vessels.
Blood vessels are the tubular structure including a vein, artery, or capillary which carries the blood through the tissues and organs pumped by the heart.
There are 3 main types of blood vessel
* Arteries that deliver oxygen-rich blood from the heart to the tissues and organs of the body. Damage of arteries is found to induce coronary artery disease caused by narrowing or blockage of the coronary arteries due to plaques accumulated on the arterial wall.
* Veins that carry blood toward the heart. Chronic venous insufficiency (CVI) is a common condition associated with a disease of the veins that affects up to 20 percent of adults.
* Capillaries (the smallest blood vessels) have been found to induce systemic capillary leak syndrome (SCLS) is a rare acquired disorder.
Some researchers suggested that following a healthy diet accompanied by moderate exercise may have a strong impact on the blood vessels' integrity.
Dr. Hanrui Zhang said, "Accumulating evidence suggests that inflammatory cytokine tumor necrosis factor-alpha (TNFα) plays a pivotal role in the dysregulation of macrovascular and microvascular function".
And, "Dietary supplements and exercise training decrease TNFαproduction and ameliorate TNFα-mediated pathological changes in vasculature. Thus, the inhibitory effects of dietary supplements and physical exercise on TNFα production and TNFα signaling may contribute to their vasoprotective properties".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
On finding a natural ingredient that processes vasoactive and vasoprotective properties, researchers examined the effects of anthocyanin-rich extracts prepared from chokeberry (Ck), bilberry (B), or elderberry (E). on reactive oxygen species (ROS) play a critical role in the impairment of nitric oxide-mediated vascular functions.
In Coronary arterial rings isolated from 64 pigs and incubated in sterile tissue culture media overnight, Ck and B, but not E, produced dose- and endothelium-dependent vasorelaxation.
In coronary vascular tone, endothelium-dependent vasorelaxation by other factors was not affected by exposure of rings to any extract at 0.05 mg total anthocyanins per liter for 5 or 30 min.
Furthermore, anthocyanin-enhanced extracts produce endothelium-dependent relaxation in porcine coronary arteries.
However, high doses of B exerted a significant protective effect against the alternation of coronary arteries induced by ROS with no effect on vasorelaxation to endogenous or exogenous NO.
Based on the findings, researchers wrote, "These results suggest that such extracts could have significant beneficial effects in vascular disease".
Taken together, bilberry-processed abundantly bioactive compound anthocyanin may be considered a functioning remedy for the prevention and treatment of vascular disease, pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts by Bell DR1, Gochenaur K. (PubMed)
(2) Vasoprotection by Dietary Supplements and Exercise: Role of TNFα Signaling by Hanrui Zhang* and Cuihua Zhang. (PMC)
#Herbal #Turmeric Promotes Colonic Health by Enhancing the Ratio of Human Gut Microbiota, According to Studies
Kyle J. Norton
Gut microbiota is a community of microbes living in the gastrointestinal tract. Believe it or not, there are trillions of microorganisms, including at least 1,000 different species of known bacteria with more than 3 million genes.
In a healthy individual, the ratio of good and bad microbes in the gut are balanced. However, people who are under constant stress or have a psychological condition such as anxiety, and depression, and long-term use of antibiotics may have a negative impact on the ratio.
In other words, emotional problems, the use of antibiotics may alter the ratio of the microbes in the gut, leading to inflammation, oxidative stress, and blood sugar imbalances.
Dr. Ruth K. Dudek-Wicher, the lead scientists wrote, "Gut microbial imbalance (dysbiosis) has been linked to important human diseases and inflammation-related disorders".
And, "...the impact of different antibiotics causing such long-term consequences as decreased microbial diversity, modulation of the Bacteroidetes/Firmicutes ratio, Clostridium difficile overgrowth, and increased expansion of the opportunistic pathogens Salmonella typhimurium, Escherichia spp., and Klebsiella spp.".
More precisely, imbalanced gut community microbes ratio can induce certain health problems including
* Decreasing the interaction with the immune function against inflammatory immune disorders.
* Increasing the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
* Reducing nutrient extraction from the diet, thus increasing the risk of obesity and obesity complications.
* Failure to control brain insulin signaling and metabolite levels can lead to bad neurobehaviors.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In finding a natural compound for the improvement of bacterial composition in the gut, researchers
examined the effects of curcumin in the gut microbiota in dysbiosis, a condition that links to many metabolic diseases.
According to the tested assays, curcumin and its derivatives exerted direct regulative effects on the gut microbiota by increasing the ratio of bacteria composition in the flavor of good bacteria.
Furthermore, in the testing the turmeric tablets in the gut microbiota determined by 16S rDNA sequencing, researchers divided.14 healthy human subjects into 3 groups with extract of piperine (Bioperine) (n = 6), curcumin with Bioperine tablets (n = 5), or placebo tablets (n = 3).
According to the bacterial analysis, turmeric-treated subjects displayed a modest 7% increase in observed species compared to control with an overall reduction in species by 15%.
Moreover, curcumin displayed an average increase of 69% in detected species, depending on the gut microbiota response to individual subjects.
More precisely, in "responsive" subjects curcumin increased in most Clostridium spp., Bacteroides spp., Citrobacter spp., Cronobacter spp., Enterobacter spp., Enterococcus spp., Klebsiella spp., Parabacteroides spp., and Pseudomonas spp. and reduced relative abundance of several Blautia spp. and most Ruminococcus spp.
In other words, curcumin improved the ratio of gut microbiota by stimulating the production of "good bacterial and reducing the levels of "bad" bacterias in the colon.
Based on the findings, researchers wrote, "All participants' microbiota displayed significant variation over time and individualized response to treatment. Among the responsive participants, both turmeric and curcumin altered the gut microbiota in a highly similar manner".
Taken altogether, turmeric may be considered a supplement for the prevention and treatment of an imbalanced ratio of gut microbiome composition, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Gut Microbiota as a Prospective Therapeutic Target for Curcumin: A Review of Mutual Influence by Zam W. (PubMed)
(2) Effects of Turmeric and Curcumin Dietary Supplementation on Human Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled Pilot Study by Peterson CT1, Vaughn AR2,3, Sharma V4, Chopra D1,5, Mills PJ1, Peterson SN4, Sivamani RK. (PubMed)
(3) The influence of antibiotics and dietary components on gut microbiota by Ruth K. Dudek-Wicher,
Adam Junka, and Marzenna Bartoszewicz. (PMC)
Gut microbiota is a community of microbes living in the gastrointestinal tract. Believe it or not, there are trillions of microorganisms, including at least 1,000 different species of known bacteria with more than 3 million genes.
In a healthy individual, the ratio of good and bad microbes in the gut are balanced. However, people who are under constant stress or have a psychological condition such as anxiety, and depression, and long-term use of antibiotics may have a negative impact on the ratio.
In other words, emotional problems, the use of antibiotics may alter the ratio of the microbes in the gut, leading to inflammation, oxidative stress, and blood sugar imbalances.
Dr. Ruth K. Dudek-Wicher, the lead scientists wrote, "Gut microbial imbalance (dysbiosis) has been linked to important human diseases and inflammation-related disorders".
And, "...the impact of different antibiotics causing such long-term consequences as decreased microbial diversity, modulation of the Bacteroidetes/Firmicutes ratio, Clostridium difficile overgrowth, and increased expansion of the opportunistic pathogens Salmonella typhimurium, Escherichia spp., and Klebsiella spp.".
More precisely, imbalanced gut community microbes ratio can induce certain health problems including
* Decreasing the interaction with the immune function against inflammatory immune disorders.
* Increasing the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
* Reducing nutrient extraction from the diet, thus increasing the risk of obesity and obesity complications.
* Failure to control brain insulin signaling and metabolite levels can lead to bad neurobehaviors.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In finding a natural compound for the improvement of bacterial composition in the gut, researchers
examined the effects of curcumin in the gut microbiota in dysbiosis, a condition that links to many metabolic diseases.
According to the tested assays, curcumin and its derivatives exerted direct regulative effects on the gut microbiota by increasing the ratio of bacteria composition in the flavor of good bacteria.
Furthermore, in the testing the turmeric tablets in the gut microbiota determined by 16S rDNA sequencing, researchers divided.14 healthy human subjects into 3 groups with extract of piperine (Bioperine) (n = 6), curcumin with Bioperine tablets (n = 5), or placebo tablets (n = 3).
According to the bacterial analysis, turmeric-treated subjects displayed a modest 7% increase in observed species compared to control with an overall reduction in species by 15%.
Moreover, curcumin displayed an average increase of 69% in detected species, depending on the gut microbiota response to individual subjects.
More precisely, in "responsive" subjects curcumin increased in most Clostridium spp., Bacteroides spp., Citrobacter spp., Cronobacter spp., Enterobacter spp., Enterococcus spp., Klebsiella spp., Parabacteroides spp., and Pseudomonas spp. and reduced relative abundance of several Blautia spp. and most Ruminococcus spp.
In other words, curcumin improved the ratio of gut microbiota by stimulating the production of "good bacterial and reducing the levels of "bad" bacterias in the colon.
Based on the findings, researchers wrote, "All participants' microbiota displayed significant variation over time and individualized response to treatment. Among the responsive participants, both turmeric and curcumin altered the gut microbiota in a highly similar manner".
Taken altogether, turmeric may be considered a supplement for the prevention and treatment of an imbalanced ratio of gut microbiome composition, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Gut Microbiota as a Prospective Therapeutic Target for Curcumin: A Review of Mutual Influence by Zam W. (PubMed)
(2) Effects of Turmeric and Curcumin Dietary Supplementation on Human Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled Pilot Study by Peterson CT1, Vaughn AR2,3, Sharma V4, Chopra D1,5, Mills PJ1, Peterson SN4, Sivamani RK. (PubMed)
(3) The influence of antibiotics and dietary components on gut microbiota by Ruth K. Dudek-Wicher,
Adam Junka, and Marzenna Bartoszewicz. (PMC)
#Healthyfood #Onion Protects the Neurons Against the Risk of Neurological Diseases, According to Studies
Neuroprotection is a process to preserve the neuronal structure and/or function against the death or gradual death of neurons, including the use of medicines and herbs.
In other words, neuroprotection protects the neuronal integrity against the reduction in the rate of neuronal loss over time inducing neurological disease, including neurodegenerative disease.
Neurodegenerative disease is the class of conditions associated with the progressive loss of neurons that occurs mostly in older adults, including dementia. The most common dementia in the US is Alzheimer`s disease (AD).
Alzheimer's disease is an irreversible, progressive brain disorder caused by the slow loss of neuron in the brain that affects memory and thinking skills and, eventually, the ability to carry out the simplest tasks as the disease progress into an advanced stage.
According to the statistics, dementia affects over 47.5 million people worldwide, and approximately 58 percent are living in low and middle-income countries.
Believe it or not, 5.8 million Americans of all ages are living with Alzheimer's dementia in 2019 and two-thirds of people with Alzheimer's disease are women.
Conventionally, as of today, there is no cure for dementia. Treatment of dementia is focusing to improve dementia symptoms and slow down the progression of the disease.
Some researchers suggested that the increased incidence of the onset of Alzheimer's disease over the past few decades may be correlated to the promotion of a high-fat diet in the US.
Dr. Rollins CPE, the lead scientist wrote, "HFD-induced obesity during adolescence exacerbated brain volume alterations by adult life in the 3xTg mouse model in comparison to control-fed mice and mediated volumetric alterations of select brain regions, such as the hippocampus".
And, "Further, HFD-induced obesity aggravated memory in all mice, lowering certain memory measures of B6129s control mice to the level of 3xTg mice maintained on a CD. Moreover, a decline in the volumetric trajectories of hippocampal regions for all mice was associated with the degree of spatial memory impairments on the MWM.".
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
In finding a potential compound for the treatment of cognitive impairment, researchers examined the neuroprotective potential of Allium cepa (A. cepa, Onion) in aluminum chloride-induced animal model neurotoxicity.
The study included mice induced neurotoxicity by aluminum chloride (50 mg/kg/day) orally were treated by supplemented with different doses of A. cepa hydroethanolic extract for a period of 60 days.
Before the treatment of onion, aluminum chloride treated mice resulted in significant motor incoordination and memory deficits, observed by the increased oxidative stress and elevated levels of acetylcholinesterase (AChE) and aluminum levels in the brain.
Onion supplement injection in aluminum-exposed animals not only significantly improved muscle coordination and memory deficits but also decreased the levels of oxidative stress, and AChE and decreased abnormal aluminum deposition induced by the aluminum chloride.
Decreased vacuolated cytoplasm associated with the death of neurons and pyramidal cells in the hippocampal area of the mice brain caused by toxicity was also reversed by the injection of A. cepa supplementation.
The results strongly suggested that onion processes anti-neuro-toxicity induced cognitive impairment in an animal model.
Dr. Singh T, the lead scientist, after taking other factors into account wrote, "significant neuroprotective potential of A. cepa in aluminum-induced neurotoxicity".
Taken altogether, onion may be considered a neuroprotective remedy, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective effect of Allium cepa L. in aluminium chloride induced neurotoxicity by Singh T1, Goel RK. (PubMed)
(2) Protective effects of onion-derived quercetin on glutamate-mediated hippocampal neuronal cell death by Yang EJ1, Kim GS, Kim JA, Song KS. (PubMed)
(3) Contributions of a high-fat diet to Alzheimer's disease-related decline: A longitudinal behavioural and structural neuroimaging study in mouse models by Rollins CPE1, Gallino D2, Kong V3, Ayranci G2, Devenyi GA4, Germann J2, Chakravarty MM. (PubMed)
#Herbal #Ashwagandha (WA) #Extracts (Alcoholic and Water) Exert Neuroprotective Potential, Researchers Show
Kyle J. Norton
The brain formed part of the central nervous system is the most complex organ made up of more than billions of nerve cells or neurons.
The functions of the brain are associated with the communication of trillions of connections called synapses and many specialized regions.
A neuron or nerve cell made of a cell body (also called soma), dendrites, and an axon, is a cell in the nervous system that carries electrical impulses.
Neurons are core components of the brain, spinal cord, and peripheral nerves that play an essential role in processing and transmitting information.
The function of neurons can be classified into 3 types
* The sensory neurons found within the nervous system that convert external stimuli from the organism's environment into internal electrical impulses. In other words, sensory neurons are activated by sensory input from the environment, including physical input of sound, touch, heat, or light.
* The motor neurons transmit information from the spinal cord to skeletal and smooth muscles,. In other words, motor neurons directly control all of the muscle movements.
* The interneurons connect the motor and sensory neurons. In other words, the interneurons transfer signals between sensory and motor neurons.
Believe it or not, there are more than 600 diseases of the central nervous system, including brain tumors, epilepsy, dementia such as Parkinson's disease Alzheimer's disease, and stroke.
The top 3 of neurological diseases include
* Alzheimer's disease (AD) is a neurodegenerative disease in the elderly, associated with the worsening of memory, thinking, and behavior that severe enough to affect language communication, memory, lifelong hobbies, or social life
* Bell's Palsy is a condition caused by sudden weakness or paralysis of facial muscles on one side of the face.
* Cerebral Palsy is a neurological disorder of children affecting a child's movement, motor skills, and muscle tone.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In finding a potent compound for the treatment of brain health, researchers examined the effects of Ashwagandha (WA) extracts (alcoholic and water) and their bioactive components for neuroprotective activities against oxidative stress in cultured glioblastoma and neuroblastoma cells.
According to the tested analysis, the extracts and one of the purified components at a low dose protected the glial and neuronal cells from oxidation, an important activity that promotes neuron activity.
Furthermore, glutamate insult induced by oxidative stress was also inhibited by the application of Ashwagandha (WA) extracts (alcoholic and water) and their bioactive components.
Based on the findings, researchers said, "the combinations of extracts and active component were highly potent endorsing the therapeutic merit of the combinational approach".
And, "Ashwagandha leaf-derived bioactive compounds have neuroprotective potential and may serve as a supplement for brain health".
Taken together, Ashwagandha may be considered a functional herb for the promotion of brain functioning, pending the result of a larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combinations of Ashwagandha leaf extracts protect brain-derived cells against oxidative stress and induce differentiation by Shah N1, Singh R1, Sarangi U1, Saxena N1, Chaudhary A1, Kaur G2, Kaul SC1, Wadhwa R. (PubMed)
(2) Protective role of Ashwagandha leaf extract and its component withanone on scopolamine-induced changes in the brain and brain-derived cells by Konar A1, Shah N, Singh R, Saxena N, Kaul SC, Wadhwa R, Thakur MK. (PubMed)
The brain formed part of the central nervous system is the most complex organ made up of more than billions of nerve cells or neurons.
The functions of the brain are associated with the communication of trillions of connections called synapses and many specialized regions.
A neuron or nerve cell made of a cell body (also called soma), dendrites, and an axon, is a cell in the nervous system that carries electrical impulses.
Neurons are core components of the brain, spinal cord, and peripheral nerves that play an essential role in processing and transmitting information.
The function of neurons can be classified into 3 types
* The sensory neurons found within the nervous system that convert external stimuli from the organism's environment into internal electrical impulses. In other words, sensory neurons are activated by sensory input from the environment, including physical input of sound, touch, heat, or light.
* The motor neurons transmit information from the spinal cord to skeletal and smooth muscles,. In other words, motor neurons directly control all of the muscle movements.
* The interneurons connect the motor and sensory neurons. In other words, the interneurons transfer signals between sensory and motor neurons.
Believe it or not, there are more than 600 diseases of the central nervous system, including brain tumors, epilepsy, dementia such as Parkinson's disease Alzheimer's disease, and stroke.
The top 3 of neurological diseases include
* Alzheimer's disease (AD) is a neurodegenerative disease in the elderly, associated with the worsening of memory, thinking, and behavior that severe enough to affect language communication, memory, lifelong hobbies, or social life
* Bell's Palsy is a condition caused by sudden weakness or paralysis of facial muscles on one side of the face.
* Cerebral Palsy is a neurological disorder of children affecting a child's movement, motor skills, and muscle tone.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In finding a potent compound for the treatment of brain health, researchers examined the effects of Ashwagandha (WA) extracts (alcoholic and water) and their bioactive components for neuroprotective activities against oxidative stress in cultured glioblastoma and neuroblastoma cells.
According to the tested analysis, the extracts and one of the purified components at a low dose protected the glial and neuronal cells from oxidation, an important activity that promotes neuron activity.
Furthermore, glutamate insult induced by oxidative stress was also inhibited by the application of Ashwagandha (WA) extracts (alcoholic and water) and their bioactive components.
Based on the findings, researchers said, "the combinations of extracts and active component were highly potent endorsing the therapeutic merit of the combinational approach".
And, "Ashwagandha leaf-derived bioactive compounds have neuroprotective potential and may serve as a supplement for brain health".
Taken together, Ashwagandha may be considered a functional herb for the promotion of brain functioning, pending the result of a larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combinations of Ashwagandha leaf extracts protect brain-derived cells against oxidative stress and induce differentiation by Shah N1, Singh R1, Sarangi U1, Saxena N1, Chaudhary A1, Kaur G2, Kaul SC1, Wadhwa R. (PubMed)
(2) Protective role of Ashwagandha leaf extract and its component withanone on scopolamine-induced changes in the brain and brain-derived cells by Konar A1, Shah N, Singh R, Saxena N, Kaul SC, Wadhwa R, Thakur MK. (PubMed)
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