Kyle J. Norton
Cancer is a class of diseases associated with the growth of cells disorderly and uncontrollably due to the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.
However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite, and fatigue but also localized symptoms depending on the affected tissues and organs.
Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.
According to the statistics provided by the American Cancer Society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Angiogenesis is the process that develops new blood vessels from pre-existing vessels by invasive tumors to provide energy(nutrition and fluids) for cancerous cells' growth and proliferation.
Cancers are the second leading cause of death worldwide besides heart diseases.
The most common types of cancer in Canada include lung, colorectal, breast, and prostate cancers. These 4 cancers account for half of all cancers diagnosed in Canada.
Leek is a genius of Allium, belonging to the vegetable family vegetable Alliacaea, the same as onion and garlic. Leeks are easy to grow from seed usually reach maturity in the autumn months, and have few pest or disease problems.
On finding a potential plant that processes anti-tumor growth activity researchers compared the anticancer properties of various sulfur and organic compounds like S-allyl mercaptocysteine, quercetin, flavonoids, and ajoene on cancer.
According to the analysis,
* These compounds with various mechanisms such as hindering the cell cycle, inhibiting signaling pathways, inducing apoptosis, and antioxidant activity interfere with diverse stages of formation, growth, differentiation, and metastasis of cancer cells.
* Similar to garlic and onion, other species such as leeks have exhibited anticancer activities, so active natural molecules extracted from them might serve as possible anticancer agents.
Collectively, researchers said, "In this review, we aim to summarize the available data on anticancer mechanisms of 16 species of Allium genus and their major compounds to assist further research on the treatment and prevention of cancers".
Taken together, leeks may be considered a functional food for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Allium vegetables for possible future of cancer treatment by Asemani Y1, Zamani N2, Bayat M1, Amirghofran Z. (PubMed)
Saturday, 28 October 2023
#Papaya Inhibits the Onset of Chronic Inflammatory Diseases by Suppreesing the Production of Pro-Inflammatory Cytokines, Researchers Say
Kyle J. Norton
Papaya is found to process anti-acute and chronic inflammatory activity that may be considered an adjunct therapy for the treatment of several chronic diseases, some scientists suggested
Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.
Any inflammation that lasts more than 3 months is considered chronic inflammation.
Truly, the main focus of inflammation is to repair damage and injury.
However, overexpression of inflammatory cytokines in most cases can cause improper healing with scar formation or the death of nearby cells.
Chronic inflammation is the result of the immune system's inability to kill off all the microorganisms that participated in the acute phase of infection, leading to the forming of autoimmune and chronic inflammatory diseases such as RA and diabetes.
Inflammation is also can be caused by overexpression of free radicals compared to the antioxidant enzymes in the body. This result can lead to an imbalance of the ratio of the levels of free radicals and antioxidants, the major cause of oxidative stress.
Longer-term oxidative stress in the body can also cause oxidative damage to biomolecules, including lipids, proteins, and DNA that initiate the development of a number of chronic diseases, such as atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction.
Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico several centuries
Chemical constituents
Alkaloids, Cardenolides, Anthraquinones, Saponins, Tannin, phenol, flavonoid, anthocyanin, Benzyl glucosinolate, benzylisothiocyanate, 5-(Hydroxymethyl)-2-furancarboxaldehyde, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 1,3-dihydroxy-2-propanone, etc.(a)
In the reaffirm fruit and vegetables have therapeutic potential as they dampen inflammation with no known side effects, researchers at the Universiti Putra Malaysia launched an evaluation to examine the effect of papaya on the activity of Th1 (IFN-γ(+) CD4(+))/Th2 (IL-4(+)CD4(+)) T cells play in mediating inflammatory responses.
According to the flow cytometry methods. application of papaya exerted a potential effect in down-regulation of IFN-γ(+) CD4(+) (p=0.03, n=13) in the expression of inflammatory markers and up-regulation of IL-4(+) CD4(+) (p=0.04, n=13) T cells, CD3(+) CD4(+) CD25(+) CD127(-) in productiuon of anti inflammatroy sytokines.
Tregs, regulatory T cells (Tregs) are a specialized subpopulation of T cells that act to suppress the immune response in the production of the proteins related to inflammation, which were found after papaya consumption.
In vitro cultures, papaya up-regulates Tregs in male subjects and was significantly associated with suppression of the levels of IL-1β and other inflammatory cytokines.
Dr. Abdullah M., the lead author said, "Papaya consumption may exert an anti-inflammatory response mediated through Tregs and have potential in alleviating inflammatory conditions".
Furthermore, in the reconfirmation of papaya anti-inflammatory effect in patients with sepsis, a serious unbalanced hyperinflammatory condition, researchers found that pretreatment of mangiferin (MF), a natural glucosyl xanthone found in papaya inhibits sepsis-activated mitogen-activated protein kinases and nuclear factor kappa-light-chain-enhancer of activated B cells signaling, the mediators with function in stimulating the production in elevating inflammatory cytokines.
Moreover, MF dose-dependently also up-regulates the expression and activity of heme oxygenase (HO)-1 which plays a critical role in the prevention of vascular inflammation in the lung of septic mice, leading to the elimination of the septic lung injury.
The findings suggested that MF attenuates sepsis by up-regulation of HO-1 that protects against sepsis-induced ALI through inhibiting inflammatory signaling and proinflammatory mediators
Taken together, papaya and its bioactive compound mangiferin (MF) may be an adjunct therapy combined with conventional medicine for the treatment of acute and chronic inflammatory diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(1) Carica papayaincreases regulatory T cells, and reduces IFN-γ+ CD4+ T cells in healthy human subjects by Abdullah M1, Chai PS, Loh CY, Chong MY, Quay HW, Vidyadaran S, Seman Z, Kandiah M, Seow HF. (PubMed)
(2) Anti-inflammatory effects of mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1 by Gong X1, Zhang L, Jiang R, Ye M, Yin X, Wan J.(PubMed)
Papaya is found to process anti-acute and chronic inflammatory activity that may be considered an adjunct therapy for the treatment of several chronic diseases, some scientists suggested
Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.
Any inflammation that lasts more than 3 months is considered chronic inflammation.
Truly, the main focus of inflammation is to repair damage and injury.
However, overexpression of inflammatory cytokines in most cases can cause improper healing with scar formation or the death of nearby cells.
Chronic inflammation is the result of the immune system's inability to kill off all the microorganisms that participated in the acute phase of infection, leading to the forming of autoimmune and chronic inflammatory diseases such as RA and diabetes.
Inflammation is also can be caused by overexpression of free radicals compared to the antioxidant enzymes in the body. This result can lead to an imbalance of the ratio of the levels of free radicals and antioxidants, the major cause of oxidative stress.
Longer-term oxidative stress in the body can also cause oxidative damage to biomolecules, including lipids, proteins, and DNA that initiate the development of a number of chronic diseases, such as atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction.
Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico several centuries
Chemical constituents
Alkaloids, Cardenolides, Anthraquinones, Saponins, Tannin, phenol, flavonoid, anthocyanin, Benzyl glucosinolate, benzylisothiocyanate, 5-(Hydroxymethyl)-2-furancarboxaldehyde, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 1,3-dihydroxy-2-propanone, etc.(a)
In the reaffirm fruit and vegetables have therapeutic potential as they dampen inflammation with no known side effects, researchers at the Universiti Putra Malaysia launched an evaluation to examine the effect of papaya on the activity of Th1 (IFN-γ(+) CD4(+))/Th2 (IL-4(+)CD4(+)) T cells play in mediating inflammatory responses.
According to the flow cytometry methods. application of papaya exerted a potential effect in down-regulation of IFN-γ(+) CD4(+) (p=0.03, n=13) in the expression of inflammatory markers and up-regulation of IL-4(+) CD4(+) (p=0.04, n=13) T cells, CD3(+) CD4(+) CD25(+) CD127(-) in productiuon of anti inflammatroy sytokines.
Tregs, regulatory T cells (Tregs) are a specialized subpopulation of T cells that act to suppress the immune response in the production of the proteins related to inflammation, which were found after papaya consumption.
In vitro cultures, papaya up-regulates Tregs in male subjects and was significantly associated with suppression of the levels of IL-1β and other inflammatory cytokines.
Dr. Abdullah M., the lead author said, "Papaya consumption may exert an anti-inflammatory response mediated through Tregs and have potential in alleviating inflammatory conditions".
Furthermore, in the reconfirmation of papaya anti-inflammatory effect in patients with sepsis, a serious unbalanced hyperinflammatory condition, researchers found that pretreatment of mangiferin (MF), a natural glucosyl xanthone found in papaya inhibits sepsis-activated mitogen-activated protein kinases and nuclear factor kappa-light-chain-enhancer of activated B cells signaling, the mediators with function in stimulating the production in elevating inflammatory cytokines.
Moreover, MF dose-dependently also up-regulates the expression and activity of heme oxygenase (HO)-1 which plays a critical role in the prevention of vascular inflammation in the lung of septic mice, leading to the elimination of the septic lung injury.
The findings suggested that MF attenuates sepsis by up-regulation of HO-1 that protects against sepsis-induced ALI through inhibiting inflammatory signaling and proinflammatory mediators
Taken together, papaya and its bioactive compound mangiferin (MF) may be an adjunct therapy combined with conventional medicine for the treatment of acute and chronic inflammatory diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(1) Carica papayaincreases regulatory T cells, and reduces IFN-γ+ CD4+ T cells in healthy human subjects by Abdullah M1, Chai PS, Loh CY, Chong MY, Quay HW, Vidyadaran S, Seman Z, Kandiah M, Seow HF. (PubMed)
(2) Anti-inflammatory effects of mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1 by Gong X1, Zhang L, Jiang R, Ye M, Yin X, Wan J.(PubMed)
#Strawberry Fruit Phenolics Exert a Strong Anti Colon Cancer Effect, Scientists Find
Kyle J. Norton
Strawberry, a delicious fruit may have a profound effect on the prevention and treatment of colon cancer, some studies suggested.
Colon cancer is a chronic medical condition characterized by abnormal cell growth which starts in the lining of colonic tissue. At the advanced stage, the cancerous cells can travel a distance away to infect other healthy tissues and organs through blood and fluid circulation.
According to the statistics provided by the American Cancer Society, colon cancer is the third most common cancer diagnosed in both men and women in the United States. In 2018, approximately, over 97,000 new cases the cancer were diagnosed, causing about 50,630 deaths.
Early diagnosed with colon cancer have an over 90% of 5 years survival rate.
The exact causes of colon cancer are unknown. However, researchers suggested that chronic inflammation of the intestines such as ulcerative colitis and Crohn's disease, and genetic mutation inherited from the parents are some prevalent major risk factors.
Furthermore, age, gender, people with polyps on the inner wall of the colon or rectum, personal and family history, poor diet, and unhealthy lifestyle are also associated with the increased risk of the onset of the disease.
Dr. Junga Lee, the lead scientist in the study "Diet and Lifestyle in Colorectal Cancer Survivors" wrote, "Lifestyle factors that include obesity, physical activity, and diet are emerging as potential critical elements in improving colorectal cancer survival outcomes". and "The association between colorectal cancer mortality and modifiable lifestyle factors is growing in evidence" and
"Changes in individual health behaviors both before and after a diagnosis of colorectal cancer may improve outcomes of survivors. Several studies have indicated that maintaining a normal weight, participating in regular physical activity, and eating a healthy diet may be important preventative steps leading to improved survival outcomes".
These results suggested that a healthy diet accompanied by an active lifestyle not only can prevent the risk of colon cancer but also can increase the survival of people who already are infected by the disease.
In the early onset of cancer, patients may not experience any symptoms. However, if you have symptoms of the change in your bowel habits that last longer than a month, accompanied by rectal bleeding or blood in your stool and persistent abdominal discomfort, please check with your doctor to rule out the possibility of colon cancer.
Strawberry is a genius of Fragaria × ananassa, belonging to the family Roseaceae. The fruits have been grown all over the world with a suitable climate for commercial profits and health benefits.
In the evaluate the recent discovery that ellagitannins (ETs), a class of hydrolyzable tannins found in some fruits and nuts, including strawberries may have beneficial effects against colon cancer, researchers at the University of Rhode Island launched an investigation to study whether, the efficacy of the ETs was a result from its function on ETs hydrolyzing the release ellagic acid (EA) and was converted by gut microbiota to urolithin A (UA; 3,8-dihydroxy-6H-dibenzopyran-6-one) type metabolites, which may persist in the colon through enterohepatic circulation.
On a human 293T cell line, using a luciferase reporter of canonical Wnt pathway-mediated transcriptional activation, researchers found that ETs isolated from strawberry= 20.5% GAE exerts a significant effect in inhibiting Wnt signaling in alternating healthy cells DNA transcript, the early sign of the onset of colon cancer.
These results suggested that strawberry with abundant bioactive compound ellagitannins (ETs) has a potential against colon carcinogenesis through gut microbiota.
In human colon cancer (CaCo-2) cells, according to the Scottish Crop Research Institute, strawberry extracts of EC 50 values in the range of 25-40 microg/(mL of phenols) demonstrated strong activity against cancer cell proliferation.
Further analysis also found that The anthocyanin-rich fraction in the strawberry extract is considerably less effective than the original extract, whereas the antiproliferative activity is retained in the tannin-rich fraction. such ad ETs.
Additionally, in the examine the hypothesis of consumption of berry fruits, including strawberries ( Fragaria x ananassa Duch.), may have beneficial effects against oxidative stress-mediated diseases such as cancer, researchers found that all 10 phenolics compound isolated from strawberry ( cyanidin-3-glucoside ( 1), pelargonidin (2), pelargonidin-3-glucoside (3), pelargonidin-3-rutinoside (4), kaempferol (5), quercetin (6), kaempferol-3-(6'-coumaroyl)glucoside) (7), 3,4,5-trihydroxyphenyl-acrylic acid (8), glucose ester of ( E)- p-coumaric acid (9), and ellagic acid) display significantly inhibitory activity against human colon cancer cell antiproliferation, by the Trolox equivalent antioxidant capacity (TEAC) and luminescent ATP cell viability assays, respectively, through the compound's antioxidant and antiproliferative activities.
Dr. Zhang Y, the lead researcher after taking into account co and confounders said, "This study adds to the growing body of data supporting the bioactivities of berry fruit phenolics and their potential impact on human health".
The findings suggested that people at a higher risk of colon cancer may want to add 1 or 2 portions of strawberries into their daily diet for preventive measures.
Taken together, strawberries processed with high levels of phenolics compound and ellagitannins (ETs) may be considered a functional food in reducing the risk and treatment of colon cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signaling by Sharma M, Li L, Celver J, Killian C, Kovoor A, Seeram NP. (PubMed)
(2) Berry extracts exert different antiproliferative effects against cervical and colon cancer cells grown in vitro by McDougall GJ, Ross HA, Ikeji M, Stewart D.(PubMed)
(3) Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative properties by Zhang Y, Seeram NP, Lee R, Feng L, Heber D.(PubMed)
(4) Diet and Lifestyle in Colorectal Cancer Survivors by Junga Lee,1 Justin Jeon,1 and Jeffrey A. Meyerhardt. (PMC)
Strawberry, a delicious fruit may have a profound effect on the prevention and treatment of colon cancer, some studies suggested.
Colon cancer is a chronic medical condition characterized by abnormal cell growth which starts in the lining of colonic tissue. At the advanced stage, the cancerous cells can travel a distance away to infect other healthy tissues and organs through blood and fluid circulation.
According to the statistics provided by the American Cancer Society, colon cancer is the third most common cancer diagnosed in both men and women in the United States. In 2018, approximately, over 97,000 new cases the cancer were diagnosed, causing about 50,630 deaths.
Early diagnosed with colon cancer have an over 90% of 5 years survival rate.
The exact causes of colon cancer are unknown. However, researchers suggested that chronic inflammation of the intestines such as ulcerative colitis and Crohn's disease, and genetic mutation inherited from the parents are some prevalent major risk factors.
Furthermore, age, gender, people with polyps on the inner wall of the colon or rectum, personal and family history, poor diet, and unhealthy lifestyle are also associated with the increased risk of the onset of the disease.
Dr. Junga Lee, the lead scientist in the study "Diet and Lifestyle in Colorectal Cancer Survivors" wrote, "Lifestyle factors that include obesity, physical activity, and diet are emerging as potential critical elements in improving colorectal cancer survival outcomes". and "The association between colorectal cancer mortality and modifiable lifestyle factors is growing in evidence" and
"Changes in individual health behaviors both before and after a diagnosis of colorectal cancer may improve outcomes of survivors. Several studies have indicated that maintaining a normal weight, participating in regular physical activity, and eating a healthy diet may be important preventative steps leading to improved survival outcomes".
These results suggested that a healthy diet accompanied by an active lifestyle not only can prevent the risk of colon cancer but also can increase the survival of people who already are infected by the disease.
In the early onset of cancer, patients may not experience any symptoms. However, if you have symptoms of the change in your bowel habits that last longer than a month, accompanied by rectal bleeding or blood in your stool and persistent abdominal discomfort, please check with your doctor to rule out the possibility of colon cancer.
Strawberry is a genius of Fragaria × ananassa, belonging to the family Roseaceae. The fruits have been grown all over the world with a suitable climate for commercial profits and health benefits.
In the evaluate the recent discovery that ellagitannins (ETs), a class of hydrolyzable tannins found in some fruits and nuts, including strawberries may have beneficial effects against colon cancer, researchers at the University of Rhode Island launched an investigation to study whether, the efficacy of the ETs was a result from its function on ETs hydrolyzing the release ellagic acid (EA) and was converted by gut microbiota to urolithin A (UA; 3,8-dihydroxy-6H-dibenzopyran-6-one) type metabolites, which may persist in the colon through enterohepatic circulation.
On a human 293T cell line, using a luciferase reporter of canonical Wnt pathway-mediated transcriptional activation, researchers found that ETs isolated from strawberry= 20.5% GAE exerts a significant effect in inhibiting Wnt signaling in alternating healthy cells DNA transcript, the early sign of the onset of colon cancer.
These results suggested that strawberry with abundant bioactive compound ellagitannins (ETs) has a potential against colon carcinogenesis through gut microbiota.
In human colon cancer (CaCo-2) cells, according to the Scottish Crop Research Institute, strawberry extracts of EC 50 values in the range of 25-40 microg/(mL of phenols) demonstrated strong activity against cancer cell proliferation.
Further analysis also found that The anthocyanin-rich fraction in the strawberry extract is considerably less effective than the original extract, whereas the antiproliferative activity is retained in the tannin-rich fraction. such ad ETs.
Additionally, in the examine the hypothesis of consumption of berry fruits, including strawberries ( Fragaria x ananassa Duch.), may have beneficial effects against oxidative stress-mediated diseases such as cancer, researchers found that all 10 phenolics compound isolated from strawberry ( cyanidin-3-glucoside ( 1), pelargonidin (2), pelargonidin-3-glucoside (3), pelargonidin-3-rutinoside (4), kaempferol (5), quercetin (6), kaempferol-3-(6'-coumaroyl)glucoside) (7), 3,4,5-trihydroxyphenyl-acrylic acid (8), glucose ester of ( E)- p-coumaric acid (9), and ellagic acid) display significantly inhibitory activity against human colon cancer cell antiproliferation, by the Trolox equivalent antioxidant capacity (TEAC) and luminescent ATP cell viability assays, respectively, through the compound's antioxidant and antiproliferative activities.
Dr. Zhang Y, the lead researcher after taking into account co and confounders said, "This study adds to the growing body of data supporting the bioactivities of berry fruit phenolics and their potential impact on human health".
The findings suggested that people at a higher risk of colon cancer may want to add 1 or 2 portions of strawberries into their daily diet for preventive measures.
Taken together, strawberries processed with high levels of phenolics compound and ellagitannins (ETs) may be considered a functional food in reducing the risk and treatment of colon cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signaling by Sharma M, Li L, Celver J, Killian C, Kovoor A, Seeram NP. (PubMed)
(2) Berry extracts exert different antiproliferative effects against cervical and colon cancer cells grown in vitro by McDougall GJ, Ross HA, Ikeji M, Stewart D.(PubMed)
(3) Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative properties by Zhang Y, Seeram NP, Lee R, Feng L, Heber D.(PubMed)
(4) Diet and Lifestyle in Colorectal Cancer Survivors by Junga Lee,1 Justin Jeon,1 and Jeffrey A. Meyerhardt. (PMC)
#ManukaHoney Inhibits Oxidativestress Diseases Asssociated with the Production of Pro-Inflammatory Cytokines, Acccording to Studies
Kyle J. Norton
Honey may be the next pharmaceutical target to identify the single ingredient medicine for the treatment of diseases associated with oxidative stress, some scientists suggested.
Oxidative stress is a result of an imbalance in the ratio of free radicals and antioxidants in the body.
Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to their nature to become stable, free radicals readily donate or steal an electron from other molecules, leading to the chain of domino effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.
This chain of reaction is the cause of oxidative stress, a condition associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.
Overexpression of free radicals is known to cause damage in contribute to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer.
Antioxidants, on the other hand, are stable molecules with a unique function in the inhibition of oxidation.
Dr. V. Lobo, the lead author in the study "Free radicals, antioxidants, and functional foods: Impact on human health" wrote, " A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues", and
"Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. Hence the application of an external source of antioxidants can assist in coping with this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health".
These results suggested that regardless of the causes of the overexpression of free radicals, intake of dietary sources of antioxidants from a supplement, herbs, fruits, and vegetables can be beneficial in restoring the healthy ratio of free radicals and antioxidants and preventing the onset of oxidative stress.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.
In order to understand the honey antioxidant activity which has been under intensified study by the science community, a joint study led by the researchers conducted was conducted in an animal model.
Ethanol-induced gastric ulcers in rats were randomly assigned to control, ethanol (ulcer), omeprazole, and manuka honey.
Honey-treated rats displayed a clinically significant decrease in the ulcer index by completely protecting the mucosa from lesions and preserving gastric mucosal glycoprotein.
Application of manuka honey also decreased gastric mucosal MDA, the marker of oxidative stress and plasma TNF-α, IL-1β, and IL-6 concentrations, the set of proinflammatory cytokines produced by the ethanol injection.
The results were attributed to the manuka honey in stimulating the production of antioxidant enzymes which were suppressed by the injection of ethanol in the tested rats.
The finding suggested that manuka honey exerted a strong antioxidant activity by balancing the ratio of free radicals and antioxidant enzymes in the treatment group.
In other words, manuka honey inhibited the oxidative stress caused by overexpression of free radicals in the initiation of the onset of the ulcer.
Further differentiation to reaffirm the effects of manuka honey in the inhibition of gastric ulcers in the rat model, researchers examined three different concentrations of honey applied to the tested rats.
During the experiment, researchers found that all 3 different concentrations display a strong effect in reducing the mucosal myeloperoxidase activity, lipid peroxidation (MDA), and the inflammatory cytokines (TNF-α, IL-1β, and IL-6) compared to the untreated control group.
In other words, manuka honey protects the rat stomach by inhibiting the overexpression of free radicals and pro-inflammatory cytokines inducing oxidative stress.
Application manuka honey also showed a significant increase in enzymatic (GPx and SOD) and nonenzymatic (GSH) antioxidants which were reduced due to ulcer and levels of the anti-inflammatory cytokine IL-10.
The Flow cytometry assay also indicated that treatment of rats with manuka honey has normalized cell cycle distribution and significantly lowered apoptosis in gastric mucosa.
The information collected strongly supports the use of manuka honey for the treatment of chronic ulcers and the preservation of mucosal glycoproteins.
Dr. Almasaudi SB wrote in the final report, "Its (manuka honey) effects are due to its antioxidant and anti-inflammatory properties that resulted in a significant reduction of the gastric mucosal MDA, TNF-α, IL-1β, and IL-6 and caused an elevation in IL-10 levels.
Taken together, there is no doubt that manuka honey high in antioxidants can be considered a functional food for the prevention and combined with the primary medicine for the treatment of diseases associated with oxidative stress.
Natural Medicine for Fattstudyver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Almasaudi SB1, El-Shitany NA2, Abbas AT3, Abdel-dayem UA4, Ali SS5, Al Jaouni SK6, Harakeh S. (PubMed)
(2) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)
(3) Protective effects of Manuka honey on LPS-treated RAW 264.7 macrophages. Part 2: Control of oxidative stress induced damage, increase of antioxidant enzyme activities and attenuation of inflammation by Gasparrini M1, Afrin S1, Forbes-Hernández TY1, Cianciosi D1, Reboredo-Rodriguez P2, Amici A1, Battino M1, Giampieri F3. (PubMed)
(4) The inflammation theory of diseas. The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment by Philip Hunter. (PubMed)
Honey may be the next pharmaceutical target to identify the single ingredient medicine for the treatment of diseases associated with oxidative stress, some scientists suggested.
Oxidative stress is a result of an imbalance in the ratio of free radicals and antioxidants in the body.
Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to their nature to become stable, free radicals readily donate or steal an electron from other molecules, leading to the chain of domino effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.
This chain of reaction is the cause of oxidative stress, a condition associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.
Overexpression of free radicals is known to cause damage in contribute to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer.
Antioxidants, on the other hand, are stable molecules with a unique function in the inhibition of oxidation.
Dr. V. Lobo, the lead author in the study "Free radicals, antioxidants, and functional foods: Impact on human health" wrote, " A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues", and
"Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. Hence the application of an external source of antioxidants can assist in coping with this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health".
These results suggested that regardless of the causes of the overexpression of free radicals, intake of dietary sources of antioxidants from a supplement, herbs, fruits, and vegetables can be beneficial in restoring the healthy ratio of free radicals and antioxidants and preventing the onset of oxidative stress.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.
In order to understand the honey antioxidant activity which has been under intensified study by the science community, a joint study led by the researchers conducted was conducted in an animal model.
Ethanol-induced gastric ulcers in rats were randomly assigned to control, ethanol (ulcer), omeprazole, and manuka honey.
Honey-treated rats displayed a clinically significant decrease in the ulcer index by completely protecting the mucosa from lesions and preserving gastric mucosal glycoprotein.
Application of manuka honey also decreased gastric mucosal MDA, the marker of oxidative stress and plasma TNF-α, IL-1β, and IL-6 concentrations, the set of proinflammatory cytokines produced by the ethanol injection.
The results were attributed to the manuka honey in stimulating the production of antioxidant enzymes which were suppressed by the injection of ethanol in the tested rats.
The finding suggested that manuka honey exerted a strong antioxidant activity by balancing the ratio of free radicals and antioxidant enzymes in the treatment group.
In other words, manuka honey inhibited the oxidative stress caused by overexpression of free radicals in the initiation of the onset of the ulcer.
Further differentiation to reaffirm the effects of manuka honey in the inhibition of gastric ulcers in the rat model, researchers examined three different concentrations of honey applied to the tested rats.
During the experiment, researchers found that all 3 different concentrations display a strong effect in reducing the mucosal myeloperoxidase activity, lipid peroxidation (MDA), and the inflammatory cytokines (TNF-α, IL-1β, and IL-6) compared to the untreated control group.
In other words, manuka honey protects the rat stomach by inhibiting the overexpression of free radicals and pro-inflammatory cytokines inducing oxidative stress.
Application manuka honey also showed a significant increase in enzymatic (GPx and SOD) and nonenzymatic (GSH) antioxidants which were reduced due to ulcer and levels of the anti-inflammatory cytokine IL-10.
The Flow cytometry assay also indicated that treatment of rats with manuka honey has normalized cell cycle distribution and significantly lowered apoptosis in gastric mucosa.
The information collected strongly supports the use of manuka honey for the treatment of chronic ulcers and the preservation of mucosal glycoproteins.
Dr. Almasaudi SB wrote in the final report, "Its (manuka honey) effects are due to its antioxidant and anti-inflammatory properties that resulted in a significant reduction of the gastric mucosal MDA, TNF-α, IL-1β, and IL-6 and caused an elevation in IL-10 levels.
Taken together, there is no doubt that manuka honey high in antioxidants can be considered a functional food for the prevention and combined with the primary medicine for the treatment of diseases associated with oxidative stress.
Natural Medicine for Fattstudyver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Almasaudi SB1, El-Shitany NA2, Abbas AT3, Abdel-dayem UA4, Ali SS5, Al Jaouni SK6, Harakeh S. (PubMed)
(2) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)
(3) Protective effects of Manuka honey on LPS-treated RAW 264.7 macrophages. Part 2: Control of oxidative stress induced damage, increase of antioxidant enzyme activities and attenuation of inflammation by Gasparrini M1, Afrin S1, Forbes-Hernández TY1, Cianciosi D1, Reboredo-Rodriguez P2, Amici A1, Battino M1, Giampieri F3. (PubMed)
(4) The inflammation theory of diseas. The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment by Philip Hunter. (PubMed)
Friday, 27 October 2023
#Eggplant Inhibits Matrices, Pathways and microRNA-21 Associated with Reducing the Risk and Treatment of #LungCancer, According to Studies
Kyle J. Norton
Eggplant may have a potential and substantial effect in reduced risk and treatment of lung cancer, some scientists suggested.
Eggplant is a species of S. melongena with a deep purple color, belonging to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
Lung cancer is a medical condition characterized by irregular cell growth in the tissues of the lung At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.
According to statistics, approximately 28,600 Canadians will be diagnosed with lung cancer representing 14% of all new cancer cases in 2017.
In the investigation of the eggplant bioactive phytochemical glycoalkaloids activity and risk of various types of malignant tumors, Dr. Friedman M found that derivatives of glycoalkaloids, α-solamargine, and α-solasonine demonstrated a strongly inhibited effect in the growth of the lung and other cancer cells in culture (in vitro) as well as tumor growth in vivo, involved some unknown signaling pathways.
More specifically, the investigation of solasodine, a naturally occurring aglycone of glycoalkaloid in eggplant (Solanum melongena) in human lung cancer cell line A549 showed that solasodine displays a significant effect in ameliorated cancer cell viability and initiated cell apoptosis through attenuating expression of mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 which were found to be elevated in patients with lung cancer in compared to healthy subjects and extracellular inducer of matrix metalloproteinase (EMMPRIN), a cell surface glycoprotein which plays an important role in stimulated the production of several matrix metalloproteinases (MMPs).
Further differentiation, also indicated that the inhibitory property of solasodine by increased expression of a reversion-inducing cysteine-rich protein with kazal motifs (RECK) not only reduces the risk of RECK accelerated cancer cell proliferation but also exhibits initiation of irreversible growth cycle arrest through short hairpin of mRNA in the suppression of the RECK gene.
Additionally, injection of solasodine promoted cancer cell death and was also associated with the overexpression of tissue inhibitor of metalloproteinase-1 (TIMP-1), a glycoprotein found in several tissues of organisms with function involved in the degradation of the extracellular matrix as mentioned above and TIMP-2, a member of the TIMP gene family with function as a metastasis suppressor.
According to the immunoblotting assays, the administration of solasodine is very effective in suppressing PI3K /Akt phosphorylation of lung cancer cells in the induction of cell proliferation.
PI3K /Akt phosphorylation plays critical roles in the regulation of many cellular processes including cell cycle, growth, apoptosis, and signal transduction pathways.
Alterations in phosphorylation pathways result in serious outcomes in the form of diseases, especially cancer.
Finally, solasodine decreased expression of microRNA-21 which has been found to be higher in more advanced malignancies, in the initiated early entry phase of cancer developing by stimulated production of RECK in accelerated cancer cell proliferation, thus decreasing the risk of cell invasion.
After taking into account all confounders, Dr. Shen KH, the lead author said, "The findings demonstrate an attractive therapeutic potential for solasodine in lung cancer anti-metastatic therapy".
Taken together, eggplant with abundant phytochemicals may be considered a functional food for attenuated risk and used in combination with standard medicine for the treatment of lung cancer.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before It's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Solasodine inhibits invasion of human lung cancer cells through downregulation of miR-21 and MMPs expression by Shen KH1, Hung JH2, Chang CW2, Weng YT2, Wu MJ2, Chen PS3. (PubMed)
(2) Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes by Friedman M1. (PubMed)
Eggplant may have a potential and substantial effect in reduced risk and treatment of lung cancer, some scientists suggested.
Eggplant is a species of S. melongena with a deep purple color, belonging to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
Lung cancer is a medical condition characterized by irregular cell growth in the tissues of the lung At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.
According to statistics, approximately 28,600 Canadians will be diagnosed with lung cancer representing 14% of all new cancer cases in 2017.
In the investigation of the eggplant bioactive phytochemical glycoalkaloids activity and risk of various types of malignant tumors, Dr. Friedman M found that derivatives of glycoalkaloids, α-solamargine, and α-solasonine demonstrated a strongly inhibited effect in the growth of the lung and other cancer cells in culture (in vitro) as well as tumor growth in vivo, involved some unknown signaling pathways.
More specifically, the investigation of solasodine, a naturally occurring aglycone of glycoalkaloid in eggplant (Solanum melongena) in human lung cancer cell line A549 showed that solasodine displays a significant effect in ameliorated cancer cell viability and initiated cell apoptosis through attenuating expression of mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 which were found to be elevated in patients with lung cancer in compared to healthy subjects and extracellular inducer of matrix metalloproteinase (EMMPRIN), a cell surface glycoprotein which plays an important role in stimulated the production of several matrix metalloproteinases (MMPs).
Further differentiation, also indicated that the inhibitory property of solasodine by increased expression of a reversion-inducing cysteine-rich protein with kazal motifs (RECK) not only reduces the risk of RECK accelerated cancer cell proliferation but also exhibits initiation of irreversible growth cycle arrest through short hairpin of mRNA in the suppression of the RECK gene.
Additionally, injection of solasodine promoted cancer cell death and was also associated with the overexpression of tissue inhibitor of metalloproteinase-1 (TIMP-1), a glycoprotein found in several tissues of organisms with function involved in the degradation of the extracellular matrix as mentioned above and TIMP-2, a member of the TIMP gene family with function as a metastasis suppressor.
According to the immunoblotting assays, the administration of solasodine is very effective in suppressing PI3K /Akt phosphorylation of lung cancer cells in the induction of cell proliferation.
PI3K /Akt phosphorylation plays critical roles in the regulation of many cellular processes including cell cycle, growth, apoptosis, and signal transduction pathways.
Alterations in phosphorylation pathways result in serious outcomes in the form of diseases, especially cancer.
Finally, solasodine decreased expression of microRNA-21 which has been found to be higher in more advanced malignancies, in the initiated early entry phase of cancer developing by stimulated production of RECK in accelerated cancer cell proliferation, thus decreasing the risk of cell invasion.
After taking into account all confounders, Dr. Shen KH, the lead author said, "The findings demonstrate an attractive therapeutic potential for solasodine in lung cancer anti-metastatic therapy".
Taken together, eggplant with abundant phytochemicals may be considered a functional food for attenuated risk and used in combination with standard medicine for the treatment of lung cancer.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before It's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Solasodine inhibits invasion of human lung cancer cells through downregulation of miR-21 and MMPs expression by Shen KH1, Hung JH2, Chang CW2, Weng YT2, Wu MJ2, Chen PS3. (PubMed)
(2) Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes by Friedman M1. (PubMed)
#Phytochemical #Betanin Inhibits the Risk of #SkinCancer, Scientists Suggest
Kyle J. Norton
Skin cancer is a chronic and medical condition caused by cell growth irregularly in the inner layer of the skin.
Skin is the largest organ in our body that covers the bone, inner organs, and tissues with a function to protect our body against the invasion of foreign pathogens.
Skin also plays an essential role in eliminating the toxins from our body, if the liver and kidney fail to do so.
Believe it or not, skin cancer accounts for more than half of the cancers diagnosed every year in the US.
As of today, 58 million Americans are living with skin cancer and one in five Americans will develop skin cancer by the age of 70.
Skin cancer is caused by a number of factors. People with fair skin, a history of sunburns, excessive sun exposure, moles, precancerous skin lesions, and a family and personal history of skin cancer are found to have an increased risk of the disease.
Some researchers suggested regardless of ethnicity and skin tone, people who live in sunny or high-altitude climates are more likely to develop skin cancer compared to people who do not.
Dr. Abrar A. Qureshi, wrote, " The risk of SCC is independently affected by residence in locations with medium and high UV indices, the gradient of risk is weaker for BCC, and the risk of melanoma does not change significantly across this gradient.
And, "Geographic location and UV radiation have been implicated as risk-modifying factors for melanoma, squamous cell carcinoma (SCC), basal cell carcinoma,...".
Betanin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In finding a potential compound for the treatment of skin cancer, researchers evaluated betanin, a major compound isolated from beetroot's skin protective effect.
The study included mouse skin tumor promotion with 3430 J/m(2) of ultraviolet light-B (UV-B) was pretreated by oral administration of 0.0025% betanin.
Betanin showed a significant protective effect in the inhibition of skin damage caused by exposure to ultraviolet light-B (UV-B).
Furthermore, at the same dose, betanin also afforded significant protection in the mouse skin cancer model caused by topical application of 390 nmol of (+/-)-(E)-4-methyl-2-[(E)-hydroxyamino]-5-nitro-6-methoxy-3-hexanamide (NOR-1) in 100 microl of acetone and 1.7 nmol of 12-O-tetradecanoylphorbol-13-acetate (TPA).
Based on the findings, suggest that betanin at a very low dose may be considered a regularly consumed natural product colorant and an effective cancer chemopreventive agent in vivo.
Taken together, betanin may be considered a supplement for the prevention and treatment of skin cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot by Kapadia GJ1, Azuine MA, Sridhar R, Okuda Y, Tsuruta A, Ichiishi E, Mukainake T, Takasaki M, Konoshima T, Nishino H, Tokuda H. (PubMed)
(2) Chemoprevention of lung and skin cancer by Beta vulgaris (beet) root extract by Kapadia GJ1, Tokuda H, Konoshima T, Nishino H. (PubMed)
(3) Geographic Variation and Risk of Skin Cancer in US WomenDifferences Between Melanoma, Squamous Cell Carcinoma, and Basal Cell Carcinoma by Abrar A. Qureshi, MD, MPH; Francine Laden, ScD; Graham A. Colditz, MD, DrPH. (JAMA Network)
Skin cancer is a chronic and medical condition caused by cell growth irregularly in the inner layer of the skin.
Skin is the largest organ in our body that covers the bone, inner organs, and tissues with a function to protect our body against the invasion of foreign pathogens.
Skin also plays an essential role in eliminating the toxins from our body, if the liver and kidney fail to do so.
Believe it or not, skin cancer accounts for more than half of the cancers diagnosed every year in the US.
As of today, 58 million Americans are living with skin cancer and one in five Americans will develop skin cancer by the age of 70.
Skin cancer is caused by a number of factors. People with fair skin, a history of sunburns, excessive sun exposure, moles, precancerous skin lesions, and a family and personal history of skin cancer are found to have an increased risk of the disease.
Some researchers suggested regardless of ethnicity and skin tone, people who live in sunny or high-altitude climates are more likely to develop skin cancer compared to people who do not.
Dr. Abrar A. Qureshi, wrote, " The risk of SCC is independently affected by residence in locations with medium and high UV indices, the gradient of risk is weaker for BCC, and the risk of melanoma does not change significantly across this gradient.
And, "Geographic location and UV radiation have been implicated as risk-modifying factors for melanoma, squamous cell carcinoma (SCC), basal cell carcinoma,...".
Betanin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In finding a potential compound for the treatment of skin cancer, researchers evaluated betanin, a major compound isolated from beetroot's skin protective effect.
The study included mouse skin tumor promotion with 3430 J/m(2) of ultraviolet light-B (UV-B) was pretreated by oral administration of 0.0025% betanin.
Betanin showed a significant protective effect in the inhibition of skin damage caused by exposure to ultraviolet light-B (UV-B).
Furthermore, at the same dose, betanin also afforded significant protection in the mouse skin cancer model caused by topical application of 390 nmol of (+/-)-(E)-4-methyl-2-[(E)-hydroxyamino]-5-nitro-6-methoxy-3-hexanamide (NOR-1) in 100 microl of acetone and 1.7 nmol of 12-O-tetradecanoylphorbol-13-acetate (TPA).
Based on the findings, suggest that betanin at a very low dose may be considered a regularly consumed natural product colorant and an effective cancer chemopreventive agent in vivo.
Taken together, betanin may be considered a supplement for the prevention and treatment of skin cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot by Kapadia GJ1, Azuine MA, Sridhar R, Okuda Y, Tsuruta A, Ichiishi E, Mukainake T, Takasaki M, Konoshima T, Nishino H, Tokuda H. (PubMed)
(2) Chemoprevention of lung and skin cancer by Beta vulgaris (beet) root extract by Kapadia GJ1, Tokuda H, Konoshima T, Nishino H. (PubMed)
(3) Geographic Variation and Risk of Skin Cancer in US WomenDifferences Between Melanoma, Squamous Cell Carcinoma, and Basal Cell Carcinoma by Abrar A. Qureshi, MD, MPH; Francine Laden, ScD; Graham A. Colditz, MD, DrPH. (JAMA Network)
Lichtwer Garlic Powder Containing #Alliin Suppresses the Onset of Hypercholesterolemia, According to Researchers
Kyle J. Norton
Hypercholesterolemia is a chronic condition associated with abnormally high blood cholesterol in the blood
In other words, hypercholesterolemia is a result of overexpression of low-density lipoprotein compared to low levels of high-density lipoprotein.
Low-density cholesterol also known as bad cholesterol produced by the liver or dietary saturated and trans fat in moderate amounts plays a critical role in building a strong cell wall, production of steroid hormones and vitamin D, and aiding the gastrointestinal tract in the absorption of nutrients.
However, high levels of bad cholesterol have been found to induce hypercholesterolemia, a leading cause of heart disease and stroke.
High-density lipoprotein or good cholesterol, on the other hand, returns the amount of excess cholesterol back to the liver for future use.
High-density lipoprotein is also produced by the liver and dietary sources found mostly in nut and fish.
The healthy ratio of LDL/HDL is any numbers less than 4.
Although there are many risk factors that cause the onset of hypercholesterolemia, some researchers suggested the introduction of a high-fat diet in North American over the past few decades may accelerate the rise of the condition.
Dr. Cole TG, the lead scientist, in a randomized controlled parallel-designed intervention study to evaluate the effects of a diet with less than 20 g carbohydrates per day (LCHF) on plasma low density lipoprotein cholesterol (LDL-C) in young and healthy adults wrote, "There was a significant increase in apolipoprotein B, total cholesterol, high-density lipoprotein cholesterol, free fatty acids, uric acid and urea in the LCHF group versus controls".
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
In finding a natural compound for the treatment of hypercholesterolemia, researchers investigated
the effect of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) on the serum cholesterol, and triglyceride in rats fed with a high cholesterol diet.
Rats selected for the study were randomly divided into experimental rats fed with a 2% high cholesterol diet with and without garlic powder for 6 weeks and control rats fed with a normal diet daily.
High cholesterol-fed animals had a significant increase in serum cholesterol compared to the control group of rats fed on a normal diet.
However, in the rat group fed with a high-cholesterol diet mixed with garlic powder, researchers found that there was a significant reduction in their serum cholesterol levels compared to other groups.
Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) also lowered the serum triglyceride levels compared to control and high cholesterol diet group rats without affecting the serum glucose and protein.
The finding clearly suggested that Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) is beneficial in reducing blood cholesterol, and the triglyceride levels in hypercholesterolemic rats.
In order to reveal more information about alliin anti-high blood cholesterol activity, researchers evaluated the capacity of Allium ursinum (wild garlic) leaf lyophilisate (WGLL; alliin content: 0.261%) to mitigate cardiovascular damage in hypercholesterolemic rabbits.
The selected New Zealand rabbits were divided into three groups: (i) cholesterol-free rabbit chow (control); (ii) rabbit chow containing 2% cholesterol (hypercholesterolemic, HC); (iii) rabbit chow containing 2% cholesterol + 2% WGLL (hypercholesterolemic treated, HCT); for eight weeks.
During the study, WGLLtreated group showed a decrease in aortic atherosclerotic plaque coverage, plasma ApoB, a protein in atherogenic lipoprotein particles associated with heart disease associated with reduced blood cholesterol.
Furthermore, the activity of LDH and CK (creatine kinase) in plasma is also found to be lower compared to other treatment groups.
The plasma LDL was also significantly reduced in the WGLL-treated group.
Taken together, alliin may be considered supplements for the prevention and treatment of hypercholesterolemia, pending the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits by Bombicz M1,2, Priksz D3,4, Varga B5,6, Gesztelyi R7, Kertesz A8, Lengyel P9, Balogh P10, Csupor D11, Hohmann J12, Bhattoa HP13, Haines DD14, Juhasz B. (PubMed)
(2) Effect of garlic on lipid profile and psychopathologic parameters in people with mild to moderate hypercholesterolemia by Peleg A1, Hershcovici T, Lipa R, Anbar R, Redler M, Beigel Y. (PubMed)
(3) Effect of low carbohydrate high fat diet on LDL cholesterol and gene expression in normal-weight, young adults: A randomized controlled study by Retterstøl K1, Svendsen M2, Narverud I3, Holven KB. (PubMed)
Hypercholesterolemia is a chronic condition associated with abnormally high blood cholesterol in the blood
In other words, hypercholesterolemia is a result of overexpression of low-density lipoprotein compared to low levels of high-density lipoprotein.
Low-density cholesterol also known as bad cholesterol produced by the liver or dietary saturated and trans fat in moderate amounts plays a critical role in building a strong cell wall, production of steroid hormones and vitamin D, and aiding the gastrointestinal tract in the absorption of nutrients.
However, high levels of bad cholesterol have been found to induce hypercholesterolemia, a leading cause of heart disease and stroke.
High-density lipoprotein or good cholesterol, on the other hand, returns the amount of excess cholesterol back to the liver for future use.
High-density lipoprotein is also produced by the liver and dietary sources found mostly in nut and fish.
The healthy ratio of LDL/HDL is any numbers less than 4.
Although there are many risk factors that cause the onset of hypercholesterolemia, some researchers suggested the introduction of a high-fat diet in North American over the past few decades may accelerate the rise of the condition.
Dr. Cole TG, the lead scientist, in a randomized controlled parallel-designed intervention study to evaluate the effects of a diet with less than 20 g carbohydrates per day (LCHF) on plasma low density lipoprotein cholesterol (LDL-C) in young and healthy adults wrote, "There was a significant increase in apolipoprotein B, total cholesterol, high-density lipoprotein cholesterol, free fatty acids, uric acid and urea in the LCHF group versus controls".
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
In finding a natural compound for the treatment of hypercholesterolemia, researchers investigated
the effect of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) on the serum cholesterol, and triglyceride in rats fed with a high cholesterol diet.
Rats selected for the study were randomly divided into experimental rats fed with a 2% high cholesterol diet with and without garlic powder for 6 weeks and control rats fed with a normal diet daily.
High cholesterol-fed animals had a significant increase in serum cholesterol compared to the control group of rats fed on a normal diet.
However, in the rat group fed with a high-cholesterol diet mixed with garlic powder, researchers found that there was a significant reduction in their serum cholesterol levels compared to other groups.
Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) also lowered the serum triglyceride levels compared to control and high cholesterol diet group rats without affecting the serum glucose and protein.
The finding clearly suggested that Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) is beneficial in reducing blood cholesterol, and the triglyceride levels in hypercholesterolemic rats.
In order to reveal more information about alliin anti-high blood cholesterol activity, researchers evaluated the capacity of Allium ursinum (wild garlic) leaf lyophilisate (WGLL; alliin content: 0.261%) to mitigate cardiovascular damage in hypercholesterolemic rabbits.
The selected New Zealand rabbits were divided into three groups: (i) cholesterol-free rabbit chow (control); (ii) rabbit chow containing 2% cholesterol (hypercholesterolemic, HC); (iii) rabbit chow containing 2% cholesterol + 2% WGLL (hypercholesterolemic treated, HCT); for eight weeks.
During the study, WGLLtreated group showed a decrease in aortic atherosclerotic plaque coverage, plasma ApoB, a protein in atherogenic lipoprotein particles associated with heart disease associated with reduced blood cholesterol.
Furthermore, the activity of LDH and CK (creatine kinase) in plasma is also found to be lower compared to other treatment groups.
The plasma LDL was also significantly reduced in the WGLL-treated group.
Taken together, alliin may be considered supplements for the prevention and treatment of hypercholesterolemia, pending the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits by Bombicz M1,2, Priksz D3,4, Varga B5,6, Gesztelyi R7, Kertesz A8, Lengyel P9, Balogh P10, Csupor D11, Hohmann J12, Bhattoa HP13, Haines DD14, Juhasz B. (PubMed)
(2) Effect of garlic on lipid profile and psychopathologic parameters in people with mild to moderate hypercholesterolemia by Peleg A1, Hershcovici T, Lipa R, Anbar R, Redler M, Beigel Y. (PubMed)
(3) Effect of low carbohydrate high fat diet on LDL cholesterol and gene expression in normal-weight, young adults: A randomized controlled study by Retterstøl K1, Svendsen M2, Narverud I3, Holven KB. (PubMed)
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