Thursday, 26 October 2023

Herbal #Turmeric and #Ginger Exert Multiple Mechanisms in the Protection of Endocrine Functioning, According to Studies

Kyle J. Norton

Scientists may have found a bioactive ingredient that protects the endocrine system integrity with no side effects, according to studies.
The endocrine system is made up of glands that produce and secrete hormones with an aim to regulate the activity of cells or organs.

In other words, the endocrine system produces hormones to regulate the body's growth, metabolism (the physical and chemical processes of the body), and sexual development and function.

Any disruption of the endocrine system can cause abnormal production of hormones, leading to developmental malformations in the infant and children, interference with the function of the reproductive organ, increased cancer risk; and disturbances in the immune and nervous system function.

The most common cause of endocrine dysfunction is exposure to men-make xenochemiclas. Particularly to those new and without testing men make chemicals introduced to the market every year.

There are many ways that endocrine disruptors can interfere with the endocrine system in hormone production such as mimic or partly mimicking naturally occurring hormones in the body like estrogens such as xanophytochemicals that bind to a receptor within a cell and block the endogenous hormone from binding.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.


The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a natural ingredient that promotes endocrine function, researchers examined the effects of ginger and turmeric on the modulation of hormone production in the body's glands.

According to the differentiation of physiological and therapeutic effects of ginger and turmeric, both exerted a significant activity in some endocrine gland functions and signal pathways by
* Inhibiting the high levels of some hormones such as T4, leptin, or interacting with hormone receptors. In other words, ginger and turmeric normalize the levels of the hormone for the body needs.

* Inhibiting the production of cytokines/adipokine expression associated with inflammation and oxidative stress.

* Inhibiting the levels of reactive oxygen species (ROS)-generating enzymes against the oxidative stress-induced hormone imbalance.


* Protecting the cell integrity against DNA alternation by promoting pro-apoptotic and inhibiting proliferative genes.

The results strongly suggested that ginger and curcumin exerted strong protection of endocrine functioning by modulating the hormones produced by the glands.

Based on the findings, researchers said, "These multiple mechanisms of protection against inflammation and oxidative damage make ginger and curcumin particularly promising natural agents in fighting the ravages of aging and degenerative diseases".

Taken altogether, turmeric combined with ginger may be considered supplements for the prevention and treatment of endocrine dysfunction, pending the confirmation of the larger sample size and multicenter human study.


Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Physiological and therapeutical roles of ginger and turmeric on endocrine functions by Al-Suhaimi EA1, Al-Riziza NA, Al-Essa RA. (PubMed)
(2) [Effect of 5 warm-hot nature Chinese drugs for promoting blood circulation and removing blood stasis on 5-HT, NE, and endocrine hormones of rats of cold coagulation and blood stasis syndrome].[Article in Chinese] by Wang P1, Fu XJ, Zhou Y, Wang ZG. (PubMed)

#Tomato and Its #Lycopene Protect Your Heart Against Cardiovascular Diseases through Its Effects on Blood LIpids, Blood Pressure, and Endothelial Function

Kyle J. Norton

Cardiovascular disease is a group of conditions involving blood vessels and heart.
In the Western world, most cases of CVD are related to a process called atherosclerosis, a condition associated with plaque build-up on the wall of arteries that reduces the oxygen-rich blood flow to the heart in facilitating the onset of heart disease and stroke, depending on the affected location.

Heart disease is a condition caused by plaque disruption that has induced significant heart muscle damage, leading to heart disease associated with symptoms


* Leg cramps during walking
Leg cramps during walking might be an indication of heart disease caused by arteries in your leg being clogged up by cholesterol in a result of not enough oxygen being delivered to the cells in your leg. If this symptom persists, please consult with your doctor.

* Chest pain
Chest pain is caused by blood vessels in the heart temporarily being blocked up by inadequate oxygen supply to the heart muscle. The persistence of chest pain would be an early indication of heart disease.

* Shortness of breath
Shortness of breath (dyspnea) is the major symptom of left ventricular insufficiency. People with shortness of breath are four times more likely to die from a heart disease-related cause than individuals without any symptoms.

* Headaches
People who see sparkling zigzag lines or loss of vision before a migraine attack may be at particular risk of future cardiovascular problems. Generally, headaches do not cause heart diseases but a sudden, explosive onset of great pain might be.

* Dizziness
Dizziness can have many causes including low blood count, low iron in the bloodstream and other blood disorders, dehydration, and viral illnesses. Since there are many different conditions that can produce these symptoms, anybody experiencing episodes of severe headaches or dizziness ought to be checked by your doctor.

* Palpitations
Palpitations is an extremely common symptom of heart disease. Palpitations are the skips in the heartbeats and irregular heartbeats.

* Loss of consciousness
It is a common symptom, most people pass out at least once in their lives. However, sometimes loss of consciousness indicates a dangerous or even life-threatening condition such as heart disease so when the loss of consciousness occurs it is important to figure out the cause.

Stroke is a condition caused either by reduced blood or rupture of a blood vessel depriving oxygen in the blood that induces the death of neurons.

Symptoms of a stroke attack can be
* Sudden trouble in standing
Sudden trouble in standing is an early symptom of stroke as a result of the circulation of blood that carries oxygen to the brain suddenly deplete caused by narrowing of arteries and high blood pressure.

* Dizziness and loss of balance
The brain coordinates information from the eyes, the inner ear, and the body's senses to maintain balance. If the cells of that part of the brain get damaged as the result of depleted oxygen will cause dizziness and loss of balance.

* Sudden confusion
A sudden onset of confusion means that something is potentially going wrong with the brain. Almost all conditions that affect the brain are life-threatening.

* Having trouble speaking and understanding
Having trouble speaking and understanding occurs when the brain cells in the area of the Broca, Wernicke, and angular gyrus in the left hemisphere area begin to die.

*Sudden severe headaches
Headache is a condition of pain in the head, sometimes neck or upper back pain may also be affected. It ranks amongst the most common local pain complaints and may be frequent for many people but sudden severe headaches may be caused by an early symptom of stroke due to the rupture of a brain vessel or depletion of oxygen in some parts of the brain.

* Sudden trouble seeing
This may be an early indication of stroke when the oxygen in the blood supply to the part of the brain is suddenly interrupted, affecting the cells that control the vision area of the cerebral cortex in the brain.

Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to discover healthy foods for the treatment of cardiovascular disease (CVD), researchers examined the effect of consuming tomato products and lycopene on markers of cardiovascular (CV) function.

By searching 3 databases including Medline, Web of Science, and Scopus from inception to August 2016, researchers identified 21 fulfilled inclusion criteria included in the meta-analyses.

All publications showed that the interventions supplementing tomato were associated with significant reductions in LDL-cholesterol, production of proinflammatory cytokine I(L-6), and improvements in flow-mediated dilation (FMD).

Compared to tomato, lycopene supplementation reduced systolic-BP (-5.66 mmHg; p = 0.002) without affecting other outcomes significantly.


Based on the results, Dr. Cheng HM, the lead scientist wrote, "The available evidence on the effects of tomato products and lycopene supplementation on CV risk factors supports the view that increasing the intake of these has positive effects on blood lipids, blood pressure, and endothelial function".

In other words, tomatoes have a potential effect on the inhibition of CVD development.

In other to review more information about tomato and its bioactive compound lycopene anti-CVD activity, researchers examined the clinical trials comparing the efficacy of lycopene supplements with tomato products on intermediate CVD risk factors.

According to the results from the clinical trial, consuming tomato-based foods is a first-line approach to cardiovascular health.

However, compared to the supplement lycopene in blood pressure management, tomato intake provided more favorable results on cardiovascular risk endpoints than did lycopene supplementation.

Taken together, tomatoes processed with a high amount of lycopene may be considered a dietary supplement for the prevention and treatment of CVD, pending to large sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To ProfessionalsPrediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis by Cheng HM1, Koutsidis G1, Lodge JK1, Ashor A2, Siervo M2, Lara J. (PubMed)
(2) Whole food versus supplement: comparing the clinical evidence of tomato intake and lycopene supplementation on cardiovascular risk factors by Burton-Freeman B, Sesso HD. (PubMed)
(3) Heart Diseases- Causes, Symptoms, Types, Preventions & Treatments by Kyle J. Norton
(4) Stroke - Causes, Symptoms The Risk Factors, Types, Preventions and Treatments by Kyle J. Norton

Organic #Onion Processes a Stronger Antioxidant Property Compared to those of Conventional Growth Onion, According to Studies

Kyle J. Norton

Antioxidants are stable molecules that inhibit oxidation.
Antioxidant enzymes either produced by the host body or from dietary sources play a critical role in the prevention of oxidative stress by balancing the expression of free radicals.

Free radicals are everywhere. Any chemical containing oxygen molecules including environmental and behavioral factors such as exposure to radiation and toxic chemicals and smoking can dramatically increase the number of free radicals in the body.

Free radicals internally are produced during the course of cell metabolism.

Oxidative stress is caused by the overexpression of free radicals compared to the low levels of antioxidant enzymes produced by the host. Over time, oxidative stress can induce proteins, lipids, and cell damage, leading to the facilitation of heart diseases, diabetes, stroke, cancer...

In other words, the chain reaction of free radicals that cannot be stopped is a leading cause of oxidative stress-induced chronic disease.

More precisely, if the antioxidant enzymes no longer can perform the function of balancing the free radicals in the body, oxidative stress occurs.

Some researchers suggested the rise of oxidative stress in the US may be correlated to the promotion of the Western diet over the past few decades.

Dr. Ildiko Erdelyi wrote, "WD induces inflammatory changes, expression profiles of a broad spectrum of inflammatory proteins were performed and numbers of lamina propria macrophages were determined with semiquantitative morphometry".

And, "WD significantly alters the local colonic immune response. Collectively, these data suggest that consumption of a WD interferes with networks of related biological response pathways involving colonic lipid metabolism, oxidative stress, and the immune response".

The results strongly suggested that by maintaining a healthy ratio of antioxidants and free radicals, diseases associated with oxidative stress can be preventable.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

With an aim to find a potential and natural compound for the prevention and treatment of diseases associated with oxidative stress, researchers examined the effect of conventional, organic, and mixed cultivation practices on the content of total phenolics, total flavonoids, and antioxidant activity in two varieties of onion grown over 4 years in a split-plot factorial systems comparison trial.

According to the experiment, levels of total phenolics and total flavonoids were significantly different between organic and conventional production systems.

Levels of antioxidants such as levels of total phenolics, and total flavonoids are significantly higher under fully organic growth compared to conventional growth.

In other words, if you are looking for the best onion with antioxidant activity, organic cultivation onion is a better choice

Based on the findings, researchers said, "organic cultivation practices resulted in significantly higher levels of potentially bioactive compounds in onion".

Taken together, onion may be considered a remedy for the prevention and treatment of diseases associated with oxidation, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Antihyperlipidemic and Antioxidative Potentials of Onion (Allium cepa L.) Extract Fermented with a Novel Lactobacillus casei HD-010 by Yang WS1,2, Kim JC3, Lee JY4, Kim CH5, Hwang CW6. (PubMed)
(2) Evaluation of polyphenolic content and antioxidant activity in two onion varieties grown under organic and conventional production systems by Ren F1,2, Reilly K1, Gaffney M1, Kerry JP2, Hossain M1, Rai DK. (PubMed)
(3) Western-Style Diets Induce Oxidative Stress and Dysregulate Immune Responses in the Colon in a Mouse Model of Sporadic Colon Cancer by Ildiko Erdelyi,4 Natasha Levenkova,5 Elaine Y. Lin,8 John T. Pinto,9 Martin Lipkin,4Fred W. Quimby,6 and Peter R. Holt. (PMC)

#Leeks Inhibit Parameters Associated with the Onset of #HighBloodCholesterol, Scientists Say

Kyle J. Norton

Cholesterol is a waxy substance that is produced either by the liver or injected from animal food sources.
Cholesterol found in our body is needed for our body to build cell walls, hormones, and vitamin D, and create bile salts that aid digestion. However, too much of them, in most cases due to the intake of animal protein can cause plaques to build up on the arterial wall, the major cause of heart disease and stroke.

More precisely, if levels of low-density lipoprotein are high compared to high-density lipoprotein which returns the accessed cholesterol back to the liver, you have high blood cholesterol.

In other words, healthy blood cholesterol is any level with either less than or equal to 4 (low-density lipoprotein/ 1 (high-density lipoprotein).

Low-density lipoprotein is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat. However, overexpression of LDL can induce plaque accumulated on the arterial wall, leading to atherosclerosis, a major cause of cardiovascular disease.

Low-density lipoprotein is produced by the liver or from dietary sources. High-density lipoprotein neutralizes the levels of LDL by returning them to the liver.

Some researchers suggested that a diet high in trans fats, saturated fat, sugar, smoking, and medical conditions such as diabetes or high blood pressure are associated with an increased risk of high blood cholesterol.

According to the statistics, in 2015-2016, by age and gender, a total of 12.4 percent of adults aged 20 years and over had high cholesterol in the United States.

Although there are many risk factors such as obesity, large waist circumference, being physically inactive, smoking, and diabetes associated with the onset of high blood cholesterol, researchers suggested that a poor diet rich in saturated and trans fat, and processed foods is the major cause of high blood cholesterol in the Western world.

Epidemiological studies indicated a healthy diet that contains a high amount of fruits and vegetables and whole grains has a positive on blood cholesterol. In other words, hyperlipidemia can be prevented by a healthy diet.

Leek is a genius of Allium, belonging to the vegetable family vegetable Alliacaea, the same as onion and garlic. Leeks are easy to grow from seed usually reach maturity in the autumn months, and have few pest or disease problems.


In finding a potential plant that processes anti-high blood cholesterol, researchers examined the effects of oral administration of Persian leek on plasma and liver lipids.

The study included male Syrian hamsters that were randomly divided into three groups: control (standard diet), high-fat control (high-fat/high-cholesterol diet), Persian leek (high-fat/high-cholesterol diet + 1% per weight of diet from dried powdered Persian leek) for 14 weeks.

Before treatment, a high-fat diet showed an increase in plasma and liver lipids compared to a standard diet.

Administration of Persian leek to the high-fat/high-cholesterol diet resulted in no significant changes in the concentration of the plasma lipids or liver cholesterol.


Liver triglycerides (TG), plasma Alanine aminotransferase, and gene expression of tumor necrosis factor- α associated with liver stress marker and pro-inflammatory cytokines, compared to high-fat diet only.


Collectively, researchers said, "Persian leek might be considered as a herbal food that can reduce liver TG accumulation induced by high-fat diets".

Taken together, leeks may be considered a functional food for the prevention and treatment of high blood cholesterol, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of Persian leek (Allium ampeloprasum) on hepatic lipids and the expression of proinflammatory gene in hamsters fed a high-fat/ high-cholesterol diet by Fatoorechi V1, Rismanchi M2, Nasrollahzadeh J. (PubMed)

#StrawberryExtract Inhibits #BreastCancer Cells by Blocking Proliferation and Inducing Apoptosis, Scientists Say

Kyle J. Norton

Breast cancer (malignant breast neoplasm) is a type of irregular cell growth that starts either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk in the breast.
In rare cases, breast cancer starts in other areas of the breast.

In 2010, over 250,000 new breast cancer cases were diagnosed in women in the U.S. alone. The risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

The causes of breast cancer are unknown. Researchers do not know, people with the same health conditions and similar family history, some are more susceptible to the onset of the disease, while others do not.

However, an increase in aging, a history of breast conditions, such as previous breast cancer, breast density, use of hormone estrogen therapy, overweight and obese, and excessive alcohol consumption are some major risk factors that can elevate the development of breast cancer.

Furthermore, genetic mutation of certain inherited from the parent such as genes BRCA1 and BRCA2 are also the prevalent risk factors of breast cancer. There is an estimation that 33% of women who carry a harmful mutation in PALB2 will develop breast cancer by age 70 years.

According to the article by the National Institute of Health, " Several different tests are available. Some tests look for a specific harmful BRCA1 orBRCA2 gene mutation that has already been identified in another family member. Other tests check for all of the known harmful mutations in both genes. Multigene (panel) testing uses next-generation sequencing to look for harmful mutations in many genes that are associated with an increased risk of breast and ovarian cancer, including BRCA1 and BRCA2, at the same time".

If you have a family history of genetic mutation involved in breast cancer, please make sure that you have them checked to rule out the possibility.

Strawberry is a genius of Fragaria × ananassa and belongs to the family Roseaceae.

The fruit has been grown all over the world with a suitable climate for commercial profits and health benefits.

The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.

Epidemiological studies strongly agree that the consumption of berry fruits, including strawberries has beneficial effects on human health and reduces the risk of chronic diseases, including breast cancer.

The Indian Institute of Science conducted an experiment to examine whether a methanolic extract of strawberry (MESB) fruits processes anticancer activity in leukemia (CEM) and breast cancer (T47D) cell lines ex vivo and its cancer therapeutic and chemopreventive potential in mice models,
* Mice-bearing breast adenocarcinoma with MESB treated by the extract blocked the proliferation of tumor cells in a time-dependent manner.

* Application of the extract also increases lifespan in the cancer-bearing animal model.

* MESB treatment affected tumor cell proliferation by activating apoptosis and did not result in any side effects

* Finally, MESB treatment also induces the intrinsic pathway of apoptosis by activating p73 in breast cancer cells, caused by the mutation of tumor suppressor gene p53.

These results revealed that strawberry fruits possess both cancer-preventive and therapeutic values.

Additionally, in the study to test for anti-breast cancer activity in extracts of six popularly consumed berries--blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry conducted by the University of California, researchers found that strawberry and other berry extracts exert their ability to inhibit the growth of human breast cancer cell line MCF-7 at concentrations ranging from 25 to 200 micro g/mL.

Moreover, researchers also discovered the apoptosis rate of breast cancer cell killing is increased with increasing concentration of the extract. These findings suggested that strawberry extract may have the potential to kill 100% of the breast cancer cells in a dose-dependent manner.

In comparison to other extracts, black raspberry and strawberry extracts showed the most significant pro-apoptotic effects against breast cell lines.

However, due to the limitation of the above studies, further data collection on large example size and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of strawberry anti-breast cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibit tumor progression in mice, by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC. (PubMed)
(2) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)

Tuesday, 24 October 2023

#Herbal #BearberryLeaf and Its Extract Exert Anti-High Blood Pressure Activity, Scientists Find

Kyle J. Norton

Herbal Barberry may be considered as a functional food and natural alternative in the prevention and treatment of high blood pressure quickly with no adverse effects, some scientists suggested. High blood pressure or hypertension is a medical condition characterized by abnormally high blood pressure.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

The normal range of blood pressure is 120 over 80. The number in the top is systolic blood pressure, and the bottom is called the diastolic blood pressure.

Researchers do not know the exact causes of hypertension. However, researchers do know that certain preventable risk factors such as smoking, being overweight or obese, physical inactivity,.... and excessive alcohol drinking are associated with an increased risk of hypertension.

Prolong periods of raising the pressure of the heart can lead to damage to the body in many ways.

Uncontrolled high blood pressure can lead to stroke and heart disease by damaging and weakening your brain's blood vessels, a blood clot in the arteries.

An unhealthy diet high in salt, sugar, process products, genetic mutation, aging, family history,... and long-term stress also have a substantial impact on the onset of hypertension.

Dr. Kim EJ, the lead author in the study of the dietary effect in patients with borderline hypertension, suggested, " a short-term (12 weeks) lifestyle intervention had positive effects on blood pressure control and weight reduction in the subjects, but not on their blood levels of adipokines. It is interesting that the blood level of baseline leptin was negatively associated with the changes in blood pressure after this short-term intervention"(3).

The results showed that long-term dietary intervention should have a strong impact on keeping blood pressure in check.

Adipocytes found in the obese population may contribute to the high prevalence of hypertension.

Leptin, a chemical compound in the blood plays a critical role in the regulation and arterial hypertension
Conventional blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they can induce serious side effects, including common gastrointestinal discomfort and psychological symptoms,

Lifelong intake of hypertension medicine can cause erectile dysfunction.

If you take the medicine in the long term, please make sure you discuss the side effects with your doctor.

Bearberries are 3 species in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.

The herbs have been used in traditional medicine as diuretic agents and to treat urinary problems, including bladder infections, kidney infections, kidney stones,.... and pelvic pain.


The Chemicals Ingredients
It contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides,..... and flavonoids.

With the aim to find the possible hypotensive activity of aqueous extract of Vaccinium Arctostaphylos leaves, the Shiraz University of Medical Sciences conducted an experiment on rats with two-kidney, one-clip hypertension.

All rats were subjected to a sham operation of the placement of a Plexiglass clip on left renal arteries.

After four weeks of surgery, renal artery-clipped rats were either injected intravenously with different doses of the extract at 10, 25, or 75 mg/kg or normal saline.

The mean blood pressure and heart rate were measured before and 20, 40, and 60 minutes after vehicle or drug administration, researchers found that

* The group given normal saline has a significantly higher mean blood pressure, heart, and right kidney weights, lower left kidney weight, and significantly indifferent heart rate.

* The treatment group with the injection of the extract at 75 mg/kg exerts a reduction of the mean blood pressure at 20, 40, and 60 minutes after administration without changing the heart rate.

* However, groups treated with doses of but 10 or 25 mg/kg show an insignificant change in mean blood pressure compared to groups administrated with the extract at 75 mg/kg.

These results suggested that bearberry leaf extract has the potential to reduce blood pressure in a dose-dependent manner.

Dr. Khalili A, the lead author of the final report, wrote, "... at a higher dose the extract did have hypotensive activity without changing the heart rate".

Truly, the Laboratoire de Pharmacognosie study of Arctostaphylos uva-ursi and hydroalcoholic extracts suggested that the test substances may process a pharmacological effect in reduced blood pressure through increasing urine flow and urinary sodium excretion in vitro.

Taking together, herbal bearberry and its extract may be considered a functional food for the treatment of high blood pressure.

However, further data collection on large example size and multi-center studies performed with human consumption of the herbal leaf extract during the course of the disease will be necessary to complete the picture of bearberry hypotensive possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before It's news, the karate GB Daily, etc.,
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
1. The effects of aqueous extract of vaccinium arctostaphylos leaves on blood pressure in renal hypertensive rats. by Khalili A, Khosravi MB, Nekooeian AA. (PubMed)
2. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats by Beaux D, Fleurentin J, Mortier F.(PubMed)
(3) Effects of a 12-week lifestyle intervention on health outcome and serum adipokines in middle-aged Korean men with borderline high blood pressure by Kim EJ1, Cho SW, Kang JY, Choi TI, Park YK(PubMed)

#Herbal #Turmeric's #Curcumin Processes Anti Bacterial Activity, Researchers Say

Kyle J. Norton

Gastritis is a group of conditions associated with the inflammation of the lining of the stomach caused by infection of the bacterium, leading to stomach ulcers developing.
A stomach ulcer is an open sore in the lining of the stomach. In most cases, it is a result of bacterial infection that leads to the erosion of the gastric lining by stomach acid.

Other causes of gastritis are long-term excessive alcohol consumption and the use of certain medication such as aspirin.

There are 2 types of gastritis
* Acute gastritis occurs suddenly as a result of inflammation or swelling in the lining of the stomach. and only affects the stomach and induces nausea or vomiting,

* Chronic gastritis is a condition that develops slowly due to chronic inflammation or damage of the stomach lining that has not healed.

Patients with chronic gastritis if untreated were found to have a substantial risk of stomach cancer.
The most common symptoms of gastritis are a burning sensation or pain in the upper abdomen, nausea, vomiting, and abnormal feeling of fullness in the upper abdomen after eating.


Out of many risk factors involved in the onset of the condition, some researchers in the observation of the correlation of high-fat diet-induced obesity over the past few decades, in the risk of gastritis wrote, "Obesity has become a major concern among gastroenterologists due to its large influence on gastrointestinal and hepatic diseases: reflux esophagitis, pancreatitis, gallstone disease, liver fibrosis, and neoplastic tumors of the esophagus, pancreas, and colon".

And, "the effects of obesity on endoscopic gastritis in subjects undergoing health check-up examination, and demonstrated that adiponectin, a bioactive molecule released from visceral fat, could be a protective factor of endoscopic gastritis".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of gastric inflammation, researchers examined the effect of diterpenoid C extracted from radix curcuma on Helicobacter pylori (H. pylori)-infected inflammation, and intestinal metaplasia.

The study included human gastric epithelial gastric epithelium cell line (GES-1) infected by I-type H. pylori treated with radix Curcuma (RC)-derived diterpenoid C of different concentrations (5, 10, 20 μg/mL) and amoxicillin.

According to the MTT assay, IC5 of RC-derived diterpenoid C and amoxicillin of 5 μg/mL inhibited the progression rate of GES-1.

The combination also inhibited the production of pro-inflammatory cytokines and exhibited the production of anti-inflammatory cytokines associated with the injection of I-type H. pylori in the GES-1,
particularly, at 12, 24, 48, and 72 h points.

In other words, the combination protects the stomach against gastric inflammation by blocking the activation of a protein involved in the stimulation of pro-inflammatory cytokines.

Based on the findings, researchers wrote, "RC-derived diterpenoid C can block NF-κB signal pathway, effectively reducing the secretion of H. pylori-induced proinflammatory cytokine and increasing the secretion of anti-inflammatory cytokine".

In Helicobacter pylori infection of the lining of the stomach induces an array of inflammatory cytokine production that leads to gastritis and peptic ulcer disease, researchers at the Uttaradit Hospital conducted an experiment to investigate the effect of curcumin on the production of interleukin (IL)-8, IL-1beta, tumor necrosis factor (TNF)-alpha and cyclooxygenase (COX)-2 in gastric mucosa from H. pylori-infected gastritis patients.

Selected patients were randomly assigned to receive either OAM (Omeprazole, Amoxicillin, and Metronidazole) treatment and/or a course of curcumin.

According to the tested assays, curcumin alone may have a limited anti-bactericidal effect on H. pylori, and on the production of inflammatory cytokines compared to those of the OAM group.


However, the curcumin group showed significant relieving symptoms with a lower rate in the eradication rate of H. pylori and no decreased cytokine production.

Precisely, curcumin used alone has limited efficacy compared to that of the combination in reducing gastric inflammation.

Taken together, turmeric processed abundant bioactive ingredient curcumin may be combined with other conventional medicines for the prevention and treatment of gastric inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of radix curcuma-derived diterpenoid C on Helicobacter pylori-induced inflammation and nuclear factor kappa B signal pathways by Huang X1, Lv B, Zhang S, Dai Q, Chen BB, Meng LN. (PubMed)
(2) Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients by Koosirirat C1, Linpisarn S, Changsom D, Chawansuntati K, Wipasa J. (PubMed)
(3) Is obesity a new risk factor for gastritis? by Yamamoto S1, Watabe K, Takehara T. (PubMed)