#Betanin Inhibits Both the Incidence and Multiplicity of #LiverCancer, According to Studies

Kyle J. Norton

Liver cancer is a medical and chronic condition characterized by uncontrollable and disordered cell growth in the liver tissues.
Most cases of liver cancer is a result of liver cell DNA altercation started in the cell on the surface of the inner lining of the tissue of the liver.

At the early stage, most patients with primary liver cancer are asymptomatic due to the small size of tumor.

According to epidemiological studies, at the advanced stage, liver cancer can lead to secondary metastasis by spreading to the breast, colon, bladder, kidney, ovary, pancreas, stomach, uterus, and lungs through the circulation of fluids and blood.

The American Cancer Society's in estimation of the primary liver cancer and intrahepatic bile duct cancer in the United States for 2019 wrote, "About 42,030 new cases (29,480 in men and 12,550 in women) will be diagnosed. About 31,780 people (21,600 men and 10,180 women) will die of these cancers".

The exact causes of liver cancer are not identified. However, worldwide, the most common risk factor for liver cancer is chronic (long-term) infection with hepatitis B virus (HBV) or hepatitis C virus (HCV).

However, some researchers suggested that compared to other hepatitis infections, the hepatitis C virus (HCV) infection is one of the major causes of liver cancer.

Dr. Luis Jesuino de Oliveria Andrade, the lead scientist wrote, " Hepatocellular carcinoma (HCC) is the fifth most common cancer, the third most common cause for cancer death in the world, a major cause of death in patients with chronic hepatitis C virus infection, and responsible for approximately one million deaths each year".

And, " Overwhelming lines of epidemiological evidence have indicated that persistent infection with hepatitis C virus (HCV) is a major risk for the development of HCC. The incidence of HCC is expected to increase in the next two decades, largely due to hepatitis C infection and secondary cirrhosis, and detection of HCC at an early stage is critical for a favorable clinical outcome".


In other words, if you are an HCV carrier, your risk of liver cancer increases substantially compared to people who are not.

Betanin is phytochemical in the red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a natural compound for the treatment of liver cancer, researchers examined the extract of Beta vulgaris (beetroot), commercially also known as betanin chemopreventive potentials in three different chemical carcinogen initiation-promotion experimental tumor models in mice.

In the two-stage model of liver cancer in mice induced by N-nitrosodiethylamine (DEN, 30 mg/kg) as the initiator and phenobarbital as the promoter, researchers found that oral administration of 0.0025% betanin showed significant inhibition of both the incidence and multiplicity of the liver tumors.

In other words, betanin inhibited the initiation and proliferation of liver cancer cells.

Surprisingly, betanin processed a strong cancer chemopreventive effect at a very low dose, compared to other herbal and phytochemical medicines.

By comparing both an in vitro Epstein-Barr early antigen activation assay and an in vivo two-stage mouse lung and skin carcinogenesis, Dr. the lead scientist said, "These findings along with our initial reports suggest that betanin which is a regularly consumed natural product colorant is an effective cancer chemopreventive agent in mice".

Taken together, betanin may be considered a supplement for the prevention and treatment of liver cancer, pending the confirmation of a larger sample size and multicenter human study.

Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot by Kapadia GJ1, Azuine MA, Sridhar R, Okuda Y, Tsuruta A, Ichiishi E, Mukainake T, Takasaki M, Konoshima T, Nishino H, Tokuda H. (PubMed)
(2) Association Between Hepatitis C and Hepatocellular Carcinoma by Luis Jesuino de Oliveria Andrade, Argemiro D'Oliveira, Junior, Rosangela Carvalho Melo,1Emmanuel Conrado De Souza,1 Carolina Alves Costa Silva, and Raymundo Paraná. (PMC)

#Ginger Improves the Cognitive Function by Inhibiting Oxidative Stress, Researchers Find

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Scientists may have found a pungent spice which processes a potential to inhibit the early onset of cognitive impairment, a major cause of neurodegenerative diseases in the elderly, according to studies.

Cognitive impairment is a medical condition characterized by a noticeable loss of cognitive abilities, involving memory and thinking skills. Cognitive impairment in the elderly is an early sign that can lead to the progression of dementia, including Alzheimer's.

The neuro impairment can be caused by brain damage due to physical impact, or a medical condition such as mild stroke. In the elderly, the syndrome was associated with the build-up of plagues or tangles in the neurons that affect the cells in transmitting information to others.


Some researchers suggested that enlargement of the brain's fluid-filled spaces and shrinkage of the hippocampus may also cause the onset of cognitive impairment.

Dr. Terry L. Davidson PhD and colleagues in examining the risk of cognitive impairment of people who follow the Western diet suggested that the Western diet may play a critical role in facilitating the widespread of cognitive impairment in the elderly in the Western world compared to the people who follow the traditional diet with a high amount of fruits and vegetables.

The doctoral team wrote, "Epidemiological studies indicate that Western diet intake, and the weight gain and obesity that it promotes, are associated not only with late-life dementia but also with poorer cognitive flexibility and inhibitory control across the lifespan".

And, " In addition, rodents maintained on a Western diet are impaired on hippocampal-dependent inhibitory learning and memory tasks and exhibit increased blood-brain barrier permeability, hippocampal inflammation, and decreased hippocampal neurogenesis and plasticity. Interference with neuroendocrine signaling may also contribute to hippocampal dysfunction".

The results strongly suggested the negative impacts of the Western diet in the initiation of a vicious cycle of progressive weight gain and cognitive decline.


Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of cognitive impairment examined the ginger effect on oxidative stress in the induction of cognitive impairment.

The study included 60 participants randomly assigned to receive a placebo or standardized plant extract at doses of 400 and 800 mg once daily for 2 months.

Ginger-treated groups had significantly decreased P300 latencies, increased N100 and P300 amplitudes, and exhibited enhanced working memory.

After one month of treatment, Zingiber officinale treated group at a dose of 800 mg showed a significant increase in N100 amplitude. After two months, Zingiber officinale treated group at doses of 400 and 800 mg showed a significant increase in P300 amplitude.
Furthermore, Zingiber officinale treated group at a dose of 800 mg showed a significant increase in N100 amplitude and de creased P300 latency.

Therefore, ginger is a potential cognitive enhancer for middle-aged women.

The P300 wave is a measurable direct reaction of the brain to a certain sensory, cognitive or mechanical stimulus against cognitive dysfunction. P300 latency is found to increase in patients with Alzheimer's disease.

The increase of N100 and N300 auditory sensory gating could reflect mechanisms involved in protecting higher-order cognitive functions. P300 measurements are used to measure the increasing sensitivity to early cognitive decline or disease progression in AD patients.

In order to reveal more information about ginger activity against cognitive impairment, researchers examined the ginger effects on healthy brains in mice.

GE administration significantly improved the ability of mice to recognize novel objects, indicating improvements in learning and memory.

GE administration led to elevated NGF levels in both the mouse hippocampus and rat glioma C6 cells.

Where nerve growth factor (NGF) is involved primarily in the growth, maintenance, proliferation, and survival of neurons, thus improving cognitive function.

Moreover, GE administration also resulted in phosphorylation of extracellular-signal-regulated kinase (ERK) and cyclic AMP response element-binding protein (CREB), linking to the regulation of synaptic plasticity and memory formation revealed by Western blotting analysis.

Additionally, GE treatment significantly increased pre- and post-synaptic markers that pass nerve impulses from an axon terminal to a neuron, muscle cell, or gland cell, and synaptophysin, and PSD-95, which are related to synapse formation in the brain.

Dr. Lim S, the lead scientist in the final report wrote, "GE has a synaptogenic effect via NGF-induced ERK/CREB activation, resulting in memory enhancement".

The MAPK/ERK pathway is a chain of proteins in the cell that transmits information from a receptor on the surface of the cell to the DNA in the nucleus of the cell.

Taken together, ginger processed with a high amount of antioxidant bioactive compounds may be considered a functional remedy for the prevention and combined with the primary therapy for the treatment of cognitive impairment, pending the confirmation of a large sample and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.


Sources
(1) Zingiber officinale Improves Cognitive Function of the Middle-Aged Healthy Women by Naritsara Saenghong, 1 Jintanaporn Wattanathorn, 2 ,* Supaporn Muchimapura, 2Terdthai Tongun, 2 Nawanant Piyavhatkul, 3 Chuleratana Banchonglikitkul, 4 andTanwarat Kajsongkram. (PubMed)
(2) Ginger improves cognitive function via NGF-induced ERK/CREB activation in the hippocampus of the mouse by Lim S1, Moon M2, Oh H1, Kim HG1, Kim SY3, Oh MS. (PubMed)
(3) Chapter 27 - Western Diet and Cognitive Impairment by Terry L.Davidson Ph.D., Camille H.Sample Ph.D., Scott E.Kanoski Ph.D. (Science Direct)

#Honey, The Best to Inhibits Chemo-toxicity and Improves 5-FU in the Treatment of Cancers, Researchers Say

Kyle J. Norton

Honey may be considered an adjunct therapy combined with the chemo drug in the improvement of the drug efficacy and reduction of chemo toxicity for the treatment of cancers, some scientists found.
Cancer is a class of chronic diseases characterized by cell growth irregularly and disorderly in the tissue of specific organs, depending on the type of cancer.

Most cases of cancer are the result of the alternation of DNA in the cell located on the surface of the inner lining of an organ. Most patients may not experience any symptoms at an early stage.

However, as cancer progresses, the continued growth of the tumor may cause pressure on the nearby healthy organs and nerve cells, leading to localized symptoms and severe pain.

At the 4th stage of cancer, malignant cells may metastasize to other organs a distance away from the original site.

According to the statistics from the National Cancer Institute, approximately, 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes.

In 2017, over 15,000 children and adolescents ages 0 to 19 were diagnosed with cancer, and 1,790 died of the disease.
Chemo drugs are medicines used for the treatment of cancer by killing cancer cells that have been spread to other tissue or organs tissues.

Chemotoxicity is the side effect of chemodrugs.

The most common symptoms of chemo drugs include the effect of blood-forming cells in the bone marrow, on hair follicles and cells in the mouth, digestive tract, and reproductive system, probably due to the medicine designed to kill cells indiscriminately.

According to the information of the pharmaceutical company, doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented by mankind.

The chemo drug used to treat a wide variety of cancers can kill cancer at every point in their life cycle.
Unfortunately, the drug can also damage heart cells and cause serious side effects, such as hair loss, breathlessness, feeling sick, and easily infected.
Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid sweetenersis considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient or whole food that processes chemopreventive properties and anti-chema toxicity during cancer treatment, researchers evaluate the effect of Kelulut honey (KH), produced by the stingless bees from Trigona species against colon cancer induced in the animal model.

A total of 24 male Sprague Dawley rats aged 5 weeks are included in the study.
Rats were divided into 4 groups: (G1) untreated group not induced with AOM, (G2) untreated group induced with AOM, (G3) treated group induced with AOM, and (G4) treated group not induced with AOM.
Injection of AOM (15 mg/kg) was via intraperitoneal route once a week for two subsequent weeks to induce colorectal cancer.
The treatment groups were given oral administration of KH (1183 mg/kg body weight) twice daily for 8 weeks.

AOM injected group showed a significant increase in the total number of aberrant crypt foci (ACF) and aberrant crypts (AC) and crypt multiplicity and damage of liver and kidney

After treatment of KH, the AOM group displayed a reduction of crypts and chemotoxicity by restoring the liver and kidney function observed by the blood profile.

Furthermore, KH was not toxically identified by the KH-treated group not induced with AOM.

These results suggested that KH may have a potential effect on inhibiting the toxicity caused by chemotherapy and improving the chemo drugs' activity without inducing any side effects.

Moreover, in finding a natural whole food to overcome 5-fluorouracil (5-FU) therapeutic resistance and adverse toxicity in colorectal cancer, researchers looked into Manuka honey (MH), a rich source of bioactive compounds to examine its anticancer effects on human colon cancer HCT-116 and LoVo cells.

Compared to 5-FU alone, MH synergistically enhanced the chemotherapeutic effects of 5-FU, by reducing cell proliferation through the suppression of enzymes and proteins associated with the function of stimulating cancer cell multicity and activation of pathways associated with cell death programming.

Combined with chemo drug 5-FU, MH promoted the expression of antibody production and production of ROS in the induction of cytotoxicity activity against cancer cells without causing to harm to the nearby cells and tissue.

This result was observed by the reducing antioxidants produced by the cancer cells and increasing oxidative stress in the tumor.

Additionally, MH also induced cancer cell apoptosis through cell cycle arrest.

The findings clearly indicated MH could be a useful preventive or adjuvant agent in the treatment of colorectal cancer with 5-FU by inhibitingtoxicity and cancer cell resistance.

Taken together, KH and MH can be considered functional foods for the prevention and adjunct therapy combined with the primary medicine for the treatment of cancer without inducing chemotoxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299

Sources
(1) Chemopreventive Properties and Toxicity of Kelulut Honey in Sprague Dawley Rats Induced with Azoxymethane by Saiful Yazan L1, Muhamad Zali MF2, Mohd Ali R3, Zainal NA2, Esa N4, Sapuan S4, Ong YS4, Tor YS4, Gopalsamy B2, Voon FL2, Syed Alwi SS. (PubMed)
(2) Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability by Afrin S1, Giampieri F1, Forbes-Hernández TY1, Gasparrini M1, Amici A1, Cianciosi D1, Quiles JL2, Battino M. (PubMed)

#Fennel Essential Oil and Extract Exert Anti Hypoglycemic Activity Scientists Find

Kyle J. Norton

Fennel may havea , a strong effect in preventing the abnormal rise of blood glucose in patients with diabetes, some scientists found.
In comparison to hyperglycemia with an excessive amount of glucose that circulates in the blood plasma, hypoglycemia is a condition of blood sugar, that falls below the levels of the normal range.

Patients with acute hypoglycemia may experience symptoms of clumsiness, trouble talking, confusion, loss of consciousness, seizures, or death.

Most cases of hyperglycemia in patients with diabetes are due to poor management. However, eating more carbohydrates than usual, less physical activity compared to normal days being sick, or high levels of stress in patients with diabetes also can cause blood glucose uptake.

Some researchers suggested that not getting the right dosage of insulin and glucose-lowering medication also causes increased blood glucose levels.

Long-term untreated hyperglycemia can elevate the onset of some serious complications including nerve damage, kidney damage and failure, heart disease, and eye disease, particularly in food and skin problems. or retinopathy foot problems caused by damaged nerves and poor blood flow skin problems, such as bacterial and fungal infections

Fennel (Foeniculum vulgare) is a plant species belongings to the family Apiaceae (Umbelliferae), native to the Mediterranean

The plant has been used in traditional and herbal medicine as warming, carminative, antispasmodic, and antidepressant agent to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle and relieve PMS,...

In the examination of the antihyperglycemic activity of fennel essential oil in an animal model, researchers launched an investigation to evaluate rats induced by bacterial streptozotocin.

At the concentrations of 30 mg/kg body weight, the essential oil of fennel demonstrated correction of hyperglycemia in the doses from 162.5 mg/dL to 81.97 ± 1.97 mg/dL by increased the serum , antioxidants activity of serum glutathione peroxidase from 59.72 U/g Hb to 99.60 U/g Hb produced by the host.

The application also improved the pathological changes noticed in their kidney and pancreas, compared to the control group.

After making the final adjustment, researchers suggested that the study not only reaffirms the use of essential oil of fennel for the treatment of hyperglycemia in folk medicine but also raises the possibility of essential oil inclusion in the antidiabetic drug industry.

Further analysis of the ethanolic and aqueous extracts of selected Sudanese plants, including fennel that is traditionally used to treat diabetes, researchers at the Khartoum College of Medical Sciences, suggested that fennel extract reveals a significant antioxidant activity in DPPH free radical scavenging assay.

However, the injection of fennel extract exhibited the highest toxicity.

These findings indicated that although fennel extract processes a substantial and positive effect in reducing the spike of blood glucose intake and the use of the fennel extract can only be prescribed by herbalists and professionals in the related field.

Additionally, in the testing, the hypoglycemic effect of a single dose of Gluconorm-5 (150, 300 and 600 mg/kg body weight) made up of five plants namely Camellia sinensis, Punica granatum, Macrotyloma uniflorum, Foeniculum vulgare and Trigonella foenum-graecum in normal, glucose loaded normal and diabetes-induced rats, researchers found that

* Fifteen days of oral feeding of the Gluconorm-5 (300 and 600 mg/kg) to diabetic rats resulted in a significant (P < 0.01) reduction of blood glucose, lipid profile, liver weight, and marker enzymes as compared to those rats in whom STZ induced toxicity was untreated.

* The diabetic rats treated with the formula showed expanded islets compared to the untreated diabetic rats, which showed shrunken islets.

* Treated rats received 300 mg/kg of Gluconorm-5 showed pronounced antidiabetic, antihyperlipidemic, and hepatoprotective effects.

This comprehensive differentiation showed that Gluconorm-5 processes potent antidiabetic antihyperlipidemic and hepatoprotective effect properties.

Taken together, fennel extract and fennel essential oil used alone or combined with other herbal antidiabetic herbal medicine can be considered an adjuvant in the treatment of hyperglycemia and diabetes mellitus.
rights

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Awardthe  over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) A study of antioxidant activity, enzymatic inhibition and in vitro toxicity of selected traditional Sudanese plants with anti-diabetic potential by Hilmi Y1, Abushama MF, Abdalgadir H, Khalid A, Khalid H(PubMed)
(3) The Dietary Furocoumarin Imperatorin Increases Plasma GLP-1 Levels in Type 1-Like Diabetic Rats by Wang LY1,2,3, Cheng KC4, Li Y5,6, Niu CS7, Cheng JT8,9, Niu HS(PubMed)
(4) Antidiabetic antihyperlipidemic and hepato-protective effect of Gluconorm-5: A polyherbal formulation in steptozotocin induced hyperglycemic rats by Gengiah K1, Hari R2, Anbu J(PubMed)

#Tomato Induces Apoptosis and Autophagy, and Angiogenesis Inhibition in Cancer, According to Studies

Kyle J. Norton

Cancer is a class of chronic and medical condition caused by cell growth irregularly in the tissues of the body.
Cancer can be classified into
* Primary cancer or original cancer is a tumor at the original site where it first arose where tumor progression began and proceeded to yield a cancerous mass.

* Secondary metastasis is a tumor spread from primary cancer.

Most cases of cancer begin in the cells on the surface of the inner lining of the organs' tissues. For example, breast cancer starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

Under normal circumstances, cell growth is a natural process without even notice, every day millions of cells grow to replace millions of dead cells and to keep our body balanced and healthy.

Sometimes, acceleration of cell growth is necessary to prevent further damage to the body tissues and organs, such as cut, injuries, etc., but after fulfilling their purposes, the growth of cells are back to a normal rate again due to our body growth inhibitors.

However, in cancer, mutated cells can grow indefinitely by accelerating cell division rates or inhibiting normal controls on the system, such as cell cycle arrest or programmed cell death, leading to the formation of cell mass or tumor.

The exact causes of cancer are unidentified. Researchers can not explain why people with the same health conditions and family history in the same family, are prone to cancer development while others do not.

According to the statistics, In 2018, approximately 1,735,350 new cases of cancer were diagnosed in the United States. The diseases also caused the death of 609,640 Americans in the same year.

Believe it or not, cancer mortality is higher among men than women (196.8 per 100,000 men and 139.6 per 100,000 women), according to the National Cancer Institute.

Tomato is red, edible fruit, genus Solanum, and belongs to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for commercial purpose
and often in the greenhouse.

In finding a natural ingredient for the prevention and treatment of cancer with no side effects researchers examined several HDACi of natural and dietary origin such as tomatoes against cancer development.

Where histone deacetylase inhibitors (HDACi) regulated the activity of histone deacetylase enzymes (HDACs) have been used in cancer treatment either alone or in combination with other chemotherapeutic drugs/radiotherapy.

According to the differential, HDACi exhibited antitumor effects by the activation of cell cycle arrest, induction of apoptosis and autophagy, and angiogenesis inhibition.

Furthermore, the cancer inhibition of HDACi is also found in increased reactive oxygen species generation that causes oxidative stress, and mitotic cell death in cancer cells.


In order to reveal more information about tomatoes' anti-cancer properties, scientists investigated lycopene-loaded whey protein isolate nanoparticles (LYC-WPI-NPs) anti-cancer activity.

The percent lycopene entrapment of prepared LYC-WPI-NPs was estimated in the range of 50 and 65%.

The WPI-NPs were found to enhance the oral bioavailability and absorption of lycopene by controlling its release from nano-formulation and lymphatic pathways.

Moreover, lycopene improved the biopharmaceutical attributes of lycopene and demonstrated prophylactic anticancer activity, decrease tumor proliferation and increased the survival rate of treated animals, in the form of loaded protein nanoparticles.

Taken together, tomatoes processed high amounts of lycopene may be considered a functional food for the treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy by Singh AK1, Bishayee A2, Pandey AK. (PubMed)
(2) Lycopene loaded whey protein isolate nanoparticles: An innovative endeavor for enhanced bioavailability of lycopene and anti-cancer activity by Jain A1, Sharma G2, Ghoshal G3, Kesharwani P4, Singh B5, Shivhare US4, Katare OP. (PubMed)

Intake of #Honey Daily and Regularly Lowers the Risk of #BladderCancer, Scientists Find

Kyle J. Norton

Scientists may have found a natural food source that processes the potential for the treatment of bladder cancer with no side effects, some studies suggested.
Bladder cancer is a medical condition characterized by irregular cell growth in the bladder.

Most cases of primary bladder cancer start in the cell on the surface of the inner lining of the bladder tissue.

At the early stage, most bladder cancers do not cause any symptoms. However, at the advanced stage, the prostate can cause a distant metastasis to infect other healthy tissues and organs through the circulation of blood and fluids.

At this advanced stage, patients may experience symptoms of pain and blood in the urine caused by the proliferative tumor suppressing the nerve cells and breaking the blood vessels in the bladder.

Researchers do not the exact causes of bladder cancer. However certain risk factors such as tobacco use, aging, gender, ethnicity, long-term bladder condition, and exposure to chemicals are at a higher risk of the onset of the disease.

The warning from the FDA also suggested the diabetes drug pioglitazone for more than 1 year may have a higher risk of developing bladder cancer.

In fact, most people with some of the above risk factors have never developed bladder cancer even if they are associated with the increased risk all their life.


Although most scientists agree that tobacco use is the major cause of bladder cancer, genetic preposition, according to epidemiological studies is also the substantial risk of bladder cancer, such as the genetic mutations in some chromosomal genes, such as FGFR3, RB1, HRAS, TP53, TSC1, and others, occur which form tumors in the urinary bladder.


Sadly, People with gene mutation are at a 70 % higher risk of bladder cancer compared to those who do not.

Dr. Zhang X, the lead author in the study "Bladder Cancer and Genetic Mutations" specified, "The changes in the genes of human chromosome 9 are usually responsible for a tumor in bladder cancer, but the genetic mutation of chromosome 22 can also result in bladder cancer". and "The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of the p53 gene".

And, "The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of p53 gene".

Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.

With an aim to find a natural ingredient for the prevention and treatment of bladder cancer without inducing any side effects, researchers at the University of Tsukuba conducted an experiment to examine the antitumor effect of bee honey against bladder cancer in vitro and in vivo.

The study included three human bladder cancer cell lines (T24, 253J, and RT4) and one murine bladder cancer cell line (MBT-2).

In vitro studies, application of honey significantly inhibited the proliferation of T24 and MBT-2 cell lines by 1-25% honey and of RT4 and 253J cell lines by 6-25% observed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay.

Bromodeoxyuridine (BrdU) labeling index, an indicator of early tumor response to the injection of honey was lower in vitro.


FCM showed lower S-phase fraction, as well as the absence of aneuploidy compared with control cells.

Flow cytometry (FCM). in the measurement of cancer cells' physical and chemical characteristics showed a lower S-phase fraction and the absence of aneuploidy compared with control cells, an indication of inhibitory cancer cells by the application of honey.

Furthermore, In the in vivo, intralesional injection of 6 and 12% honey, as well as oral ingestion of honey, significantly inhibited tumor growth.
These results suggested that bee honey processes a significant activity for inhibiting the growth of T24, RT4, 253J, and MBT-2 bladder cancer cell lines in vitro.

And, Honey is also effective when administered intralesionally or orally in the MBT-2 bladder cancer implantation models.

Dr, Swellam T, the lead author after taking into account co and confounders wrote, " Our results are promising,,,,,, the mechanisms of the antitumor activity of honey".

Taken altogether, honey may be considered a functional food for the prevention and an adjunct therapy combined with the primary medicine for the treatment of bladder cancer.

However, further data collection large example size and multi-center studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of honey anti-bladder cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vivo and in vitro studies by Swellam T1, Miyanaga N, Onozawa M, Hattori K, Kawai K, Shimazui T, Akaza H. (PubMed)
(2) Bladder Cancer and Genetic Mutations by Zhang X1, Zhang Y. (PubMed)

#Fennel Exerts a Strong Apoptotic and Anti Proliferative Activity in Several Cancer Cell Lines, Scientists Find

Kyle J. Norton

Scientists may have found a whole food or herb with the potential to activate the protein that programs the death of cancer cells, some studies found.
Cell death is a natural process to warrants the normal development of cells and the cell cycle maturation and maintain the normal function body in the optimized state.

However, some microorganisms are found to process the activity in triggering cell death for their own survival.


Apoptosis, or programmed cell death, is a function of the immune system that evolved as a rapid and irreversible process to efficiently eliminate dysfunctional cells, including cells that were damaged by the alternation of DNA or infection

Cancer apoptosis is an action that causes cancer cells to die off with or without affecting the nearby cells.

Some herbal medicines such as fennel have been shown to induce the function of overexpression of levels of free radicals in initiating a cytotoxic effect that targets cancer cells while protecting the healthy cells through its antioxidant activity.


Fennel (Foeniculum vulgare) is a plant species of the genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.

Herbal medicine has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle and relieve PMS,...

In the study to investigate several herbal plants ethanol extracts from fruits of their apoptotic activity from fruits of seven species of Apiaceae family, namely, Eryngium planum, Archangelica officinalis, Pastinaca sativa, Heracleum sibiricum, Carum carvi, Foeniculum vulgare (fennel), and Levisticum officinale against ML-1—human acute myeloblastic leukemia, J-45.01—human acute T cell leukemia, EOL—human eosinophilic leukemia, HL-60—human Caucasian promyelocytic leukemia, 1301—human T cell leukemia lymphoblast, C-8166—human T cell leukemia, U-266B1—human myeloma, WICL—human Caucasian normal B cell, and H-9—human T cell, researchers found that
* The ethanol extract from fruit F. vulgare shows the highest mortality in the Trypan blue test for the J45 cell line with 4% of viable cells and a C8166 cell line with 100% mortality.

* The extract also shows the highest viability in other cell lines, including the HL60 at 60%, EOL at 48%, and ML1 at 42%. The normal cell line H9 and WICL showed 35% and 25% of viable cells, respectively.

Furthermore, the reaffirm the use of fennel in traditional cancer treatment, researchers at the King Abdulaziz University (KAU), launched a study to demonstrate the anti-proliferative and apoptotic effect of chloroform fraction of fennel (CFF) in MCF-7 cells.

Application of fennel was shown to inhibit the growth against MCF-7 and MDA-MB-237 in time- and concentration-dependent manners.

Fennel-induced apoptosis of around 49% at the doses of 0.5 mg/ml of CFF and PI-stained cells showed the G1 phase cell cycle arrest, according to the Annexin V/PI assay.

More importantly, the application of fennel also was found to reduce the elevated levels of ROS, disrupted mitochondrial membrane, and increased levels of caspase-9 & caspase-3 and DNA fragmentation in the promotion of MCF-7 cell death.experiment

Dr. Syed FQ, the lead author in the final assessment of the experiment said, "(The results) revealed the proliferation inhibition, cell cycle arrest and apoptosis induction effect of CFF, which may help in exploring the novel anti-cancer drug for therapeutic implications".

Moreover, in the study to examine whether anethole, a major bioactive compound found in fennel, anise, and camphor processes anti-metastatic and apoptotic effects on highly-metastatic HT-1080 human fibrosarcoma tumor cells, researchers found that
* Despite weak cytotoxicity against HT-1080 cells, anethole inhibits the adhesion to Matrigel and invasion of HT-1080 cells in a dose-dependent manner.

* Anethole is also able to down-regulate the expression of matrix metalloproteinase (MMP)-2 and -9 with anti-apoptotic function and up-regulate the gene expression of tissue inhibitor of metalloproteinase (TIMP)-1 with apoptotic function.


Finally, anethole significantly decreased mRNA expression of urokinase plasminogen activator (uPA), but not uPA receptor (uPAR) in the facilitated cancer cell death.

Taken together, fennel alone or its extracts and bioactive compound anethole may be considered adjunct therapy combined with conventional medicine for the treatment of cancers


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar, Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Chloroform fraction of Foeniculum vulgare induced ROS mediated, mitochondria-caspase-dependent apoptotic pathway in MCF-7, human breast cancer cell line by Syed FQ1, Elkady AI2, Mohammed FA3, Mirza MB4, Hakeem KR5, Alkarim S(PubMed)
(3) Anethole exerts antimetatstaic activity via inhibition of matrix metalloproteinase 2/9 and AKT/mitogen-activated kinase/nuclear factor kappa B signaling pathways by Choo EJ1, Rhee YH, Jeong SJ, Lee HJ, Kim HS, Ko HS, Kim JH, Kwon TR, Jung JH, Kim JH, Lee HJ, Lee EO, Kim DK, Chen CY, Kim SH(PubMed)