Kyle J. Norton
Scientists may have found a natural food source that processes the potential for the treatment of bladder cancer with no side effects, some studies suggested.
Bladder cancer is a medical condition characterized by irregular cell growth in the bladder.
Most cases of primary bladder cancer start in the cell on the surface of the inner lining of the bladder tissue.
At the early stage, most bladder cancers do not cause any symptoms. However, at the advanced stage, the prostate can cause a distant metastasis to infect other healthy tissues and organs through the circulation of blood and fluids.
At this advanced stage, patients may experience symptoms of pain and blood in the urine caused by the proliferative tumor suppressing the nerve cells and breaking the blood vessels in the bladder.
Researchers do not the exact causes of bladder cancer. However certain risk factors such as tobacco use, aging, gender, ethnicity, long-term bladder condition, and exposure to chemicals are at a higher risk of the onset of the disease.
The warning from the FDA also suggested the diabetes drug pioglitazone for more than 1 year may have a higher risk of developing bladder cancer.
In fact, most people with some of the above risk factors have never developed bladder cancer even if they are associated with the increased risk all their life.
Although most scientists agree that tobacco use is the major cause of bladder cancer, genetic preposition, according to epidemiological studies is also the substantial risk of bladder cancer, such as the genetic mutations in some chromosomal genes, such as FGFR3, RB1, HRAS, TP53, TSC1, and others, occur which form tumors in the urinary bladder.
Sadly, People with gene mutation are at a 70 % higher risk of bladder cancer compared to those who do not.
Dr. Zhang X, the lead author in the study "Bladder Cancer and Genetic Mutations" specified, "The changes in the genes of human chromosome 9 are usually responsible for a tumor in bladder cancer, but the genetic mutation of chromosome 22 can also result in bladder cancer". and "The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of the p53 gene".
And, "The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of p53 gene".
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.
With an aim to find a natural ingredient for the prevention and treatment of bladder cancer without inducing any side effects, researchers at the University of Tsukuba conducted an experiment to examine the antitumor effect of bee honey against bladder cancer in vitro and in vivo.
The study included three human bladder cancer cell lines (T24, 253J, and RT4) and one murine bladder cancer cell line (MBT-2).
In vitro studies, application of honey significantly inhibited the proliferation of T24 and MBT-2 cell lines by 1-25% honey and of RT4 and 253J cell lines by 6-25% observed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay.
Bromodeoxyuridine (BrdU) labeling index, an indicator of early tumor response to the injection of honey was lower in vitro.
FCM showed lower S-phase fraction, as well as the absence of aneuploidy compared with control cells.
Flow cytometry (FCM). in the measurement of cancer cells' physical and chemical characteristics showed a lower S-phase fraction and the absence of aneuploidy compared with control cells, an indication of inhibitory cancer cells by the application of honey.
Furthermore, In the in vivo, intralesional injection of 6 and 12% honey, as well as oral ingestion of honey, significantly inhibited tumor growth.
These results suggested that bee honey processes a significant activity for inhibiting the growth of T24, RT4, 253J, and MBT-2 bladder cancer cell lines in vitro.
And, Honey is also effective when administered intralesionally or orally in the MBT-2 bladder cancer implantation models.
Dr, Swellam T, the lead author after taking into account co and confounders wrote, " Our results are promising,,,,,, the mechanisms of the antitumor activity of honey".
Taken altogether, honey may be considered a functional food for the prevention and an adjunct therapy combined with the primary medicine for the treatment of bladder cancer.
However, further data collection large example size and multi-center studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of honey anti-bladder cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vivo and in vitro studies by Swellam T1, Miyanaga N, Onozawa M, Hattori K, Kawai K, Shimazui T, Akaza H. (PubMed)
(2) Bladder Cancer and Genetic Mutations by Zhang X1, Zhang Y. (PubMed)
Monday, 16 October 2023
#Fennel Exerts a Strong Apoptotic and Anti Proliferative Activity in Several Cancer Cell Lines, Scientists Find
Kyle J. Norton
Scientists may have found a whole food or herb with the potential to activate the protein that programs the death of cancer cells, some studies found.
Cell death is a natural process to warrants the normal development of cells and the cell cycle maturation and maintain the normal function body in the optimized state.
However, some microorganisms are found to process the activity in triggering cell death for their own survival.
Apoptosis, or programmed cell death, is a function of the immune system that evolved as a rapid and irreversible process to efficiently eliminate dysfunctional cells, including cells that were damaged by the alternation of DNA or infection
Cancer apoptosis is an action that causes cancer cells to die off with or without affecting the nearby cells.
Some herbal medicines such as fennel have been shown to induce the function of overexpression of levels of free radicals in initiating a cytotoxic effect that targets cancer cells while protecting the healthy cells through its antioxidant activity.
Fennel (Foeniculum vulgare) is a plant species of the genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
Herbal medicine has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle and relieve PMS,...
In the study to investigate several herbal plants ethanol extracts from fruits of their apoptotic activity from fruits of seven species of Apiaceae family, namely, Eryngium planum, Archangelica officinalis, Pastinaca sativa, Heracleum sibiricum, Carum carvi, Foeniculum vulgare (fennel), and Levisticum officinale against ML-1—human acute myeloblastic leukemia, J-45.01—human acute T cell leukemia, EOL—human eosinophilic leukemia, HL-60—human Caucasian promyelocytic leukemia, 1301—human T cell leukemia lymphoblast, C-8166—human T cell leukemia, U-266B1—human myeloma, WICL—human Caucasian normal B cell, and H-9—human T cell, researchers found that
* The ethanol extract from fruit F. vulgare shows the highest mortality in the Trypan blue test for the J45 cell line with 4% of viable cells and a C8166 cell line with 100% mortality.
* The extract also shows the highest viability in other cell lines, including the HL60 at 60%, EOL at 48%, and ML1 at 42%. The normal cell line H9 and WICL showed 35% and 25% of viable cells, respectively.
Furthermore, the reaffirm the use of fennel in traditional cancer treatment, researchers at the King Abdulaziz University (KAU), launched a study to demonstrate the anti-proliferative and apoptotic effect of chloroform fraction of fennel (CFF) in MCF-7 cells.
Application of fennel was shown to inhibit the growth against MCF-7 and MDA-MB-237 in time- and concentration-dependent manners.
Fennel-induced apoptosis of around 49% at the doses of 0.5 mg/ml of CFF and PI-stained cells showed the G1 phase cell cycle arrest, according to the Annexin V/PI assay.
More importantly, the application of fennel also was found to reduce the elevated levels of ROS, disrupted mitochondrial membrane, and increased levels of caspase-9 & caspase-3 and DNA fragmentation in the promotion of MCF-7 cell death.experiment
Dr. Syed FQ, the lead author in the final assessment of the experiment said, "(The results) revealed the proliferation inhibition, cell cycle arrest and apoptosis induction effect of CFF, which may help in exploring the novel anti-cancer drug for therapeutic implications".
Moreover, in the study to examine whether anethole, a major bioactive compound found in fennel, anise, and camphor processes anti-metastatic and apoptotic effects on highly-metastatic HT-1080 human fibrosarcoma tumor cells, researchers found that
* Despite weak cytotoxicity against HT-1080 cells, anethole inhibits the adhesion to Matrigel and invasion of HT-1080 cells in a dose-dependent manner.
* Anethole is also able to down-regulate the expression of matrix metalloproteinase (MMP)-2 and -9 with anti-apoptotic function and up-regulate the gene expression of tissue inhibitor of metalloproteinase (TIMP)-1 with apoptotic function.
Finally, anethole significantly decreased mRNA expression of urokinase plasminogen activator (uPA), but not uPA receptor (uPAR) in the facilitated cancer cell death.
Taken together, fennel alone or its extracts and bioactive compound anethole may be considered adjunct therapy combined with conventional medicine for the treatment of cancers
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar, Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Chloroform fraction of Foeniculum vulgare induced ROS mediated, mitochondria-caspase-dependent apoptotic pathway in MCF-7, human breast cancer cell line by Syed FQ1, Elkady AI2, Mohammed FA3, Mirza MB4, Hakeem KR5, Alkarim S(PubMed)
(3) Anethole exerts antimetatstaic activity via inhibition of matrix metalloproteinase 2/9 and AKT/mitogen-activated kinase/nuclear factor kappa B signaling pathways by Choo EJ1, Rhee YH, Jeong SJ, Lee HJ, Kim HS, Ko HS, Kim JH, Kwon TR, Jung JH, Kim JH, Lee HJ, Lee EO, Kim DK, Chen CY, Kim SH(PubMed)
Scientists may have found a whole food or herb with the potential to activate the protein that programs the death of cancer cells, some studies found.
Cell death is a natural process to warrants the normal development of cells and the cell cycle maturation and maintain the normal function body in the optimized state.
However, some microorganisms are found to process the activity in triggering cell death for their own survival.
Apoptosis, or programmed cell death, is a function of the immune system that evolved as a rapid and irreversible process to efficiently eliminate dysfunctional cells, including cells that were damaged by the alternation of DNA or infection
Cancer apoptosis is an action that causes cancer cells to die off with or without affecting the nearby cells.
Some herbal medicines such as fennel have been shown to induce the function of overexpression of levels of free radicals in initiating a cytotoxic effect that targets cancer cells while protecting the healthy cells through its antioxidant activity.
Fennel (Foeniculum vulgare) is a plant species of the genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
Herbal medicine has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle and relieve PMS,...
In the study to investigate several herbal plants ethanol extracts from fruits of their apoptotic activity from fruits of seven species of Apiaceae family, namely, Eryngium planum, Archangelica officinalis, Pastinaca sativa, Heracleum sibiricum, Carum carvi, Foeniculum vulgare (fennel), and Levisticum officinale against ML-1—human acute myeloblastic leukemia, J-45.01—human acute T cell leukemia, EOL—human eosinophilic leukemia, HL-60—human Caucasian promyelocytic leukemia, 1301—human T cell leukemia lymphoblast, C-8166—human T cell leukemia, U-266B1—human myeloma, WICL—human Caucasian normal B cell, and H-9—human T cell, researchers found that
* The ethanol extract from fruit F. vulgare shows the highest mortality in the Trypan blue test for the J45 cell line with 4% of viable cells and a C8166 cell line with 100% mortality.
* The extract also shows the highest viability in other cell lines, including the HL60 at 60%, EOL at 48%, and ML1 at 42%. The normal cell line H9 and WICL showed 35% and 25% of viable cells, respectively.
Furthermore, the reaffirm the use of fennel in traditional cancer treatment, researchers at the King Abdulaziz University (KAU), launched a study to demonstrate the anti-proliferative and apoptotic effect of chloroform fraction of fennel (CFF) in MCF-7 cells.
Application of fennel was shown to inhibit the growth against MCF-7 and MDA-MB-237 in time- and concentration-dependent manners.
Fennel-induced apoptosis of around 49% at the doses of 0.5 mg/ml of CFF and PI-stained cells showed the G1 phase cell cycle arrest, according to the Annexin V/PI assay.
More importantly, the application of fennel also was found to reduce the elevated levels of ROS, disrupted mitochondrial membrane, and increased levels of caspase-9 & caspase-3 and DNA fragmentation in the promotion of MCF-7 cell death.experiment
Dr. Syed FQ, the lead author in the final assessment of the experiment said, "(The results) revealed the proliferation inhibition, cell cycle arrest and apoptosis induction effect of CFF, which may help in exploring the novel anti-cancer drug for therapeutic implications".
Moreover, in the study to examine whether anethole, a major bioactive compound found in fennel, anise, and camphor processes anti-metastatic and apoptotic effects on highly-metastatic HT-1080 human fibrosarcoma tumor cells, researchers found that
* Despite weak cytotoxicity against HT-1080 cells, anethole inhibits the adhesion to Matrigel and invasion of HT-1080 cells in a dose-dependent manner.
* Anethole is also able to down-regulate the expression of matrix metalloproteinase (MMP)-2 and -9 with anti-apoptotic function and up-regulate the gene expression of tissue inhibitor of metalloproteinase (TIMP)-1 with apoptotic function.
Finally, anethole significantly decreased mRNA expression of urokinase plasminogen activator (uPA), but not uPA receptor (uPAR) in the facilitated cancer cell death.
Taken together, fennel alone or its extracts and bioactive compound anethole may be considered adjunct therapy combined with conventional medicine for the treatment of cancers
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar, Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Chloroform fraction of Foeniculum vulgare induced ROS mediated, mitochondria-caspase-dependent apoptotic pathway in MCF-7, human breast cancer cell line by Syed FQ1, Elkady AI2, Mohammed FA3, Mirza MB4, Hakeem KR5, Alkarim S(PubMed)
(3) Anethole exerts antimetatstaic activity via inhibition of matrix metalloproteinase 2/9 and AKT/mitogen-activated kinase/nuclear factor kappa B signaling pathways by Choo EJ1, Rhee YH, Jeong SJ, Lee HJ, Kim HS, Ko HS, Kim JH, Kwon TR, Jung JH, Kim JH, Lee HJ, Lee EO, Kim DK, Chen CY, Kim SH(PubMed)
Daily Intake of Carrot Normalizes the Levels of Cholesterol and Reduces the Risk of Heart Diseases, Researchers Say
Kyle J. Norton
Carrots may have found a therapeutic and positive effect in inhibiting the abnormally high blood cholesterol some scientists suggested.
Hyperlipidemia is a condition characterized by abnormally high blood cholesterol in the blood.
The exact causes of the condition are unknown. However, most researchers suggested that genetic mutation inherited from the parents, unhealthy diet and lifestyle, and some medical conditions such as diabetes, kidney disease, and hypothyroidism, are the most common risk factors that cause the early onset of the syndrome.
Truly, mutation of the LDLRAP1 gene is inherited in an autosomal recessive pattern which contributes to the risk of hyperlipidemia. However, parents of the patient who carry only one copy of the altered gene, are not at risk of high blood cholesterol levels.
Dr. GS Mannu,, the lead author in the study "Evidence of Lifestyle Modification in the Management of Hypercholesterolemia" said, "Target cholesterol levels set out in various guidelines could be achieved by lifestyle changes, including diet, weight reduction, and increased physical activity with the goal of reducing total cholesterol to <200 mg/dL and LDL-C <100mg/dL. Various dietary constituents such as green tea, plant sterols, and soy protein have important influences on total cholesterol. Medical intervention should be reserved for those patients who have not reached this goal after 3 months of non-pharmacological approach".
This statement indicates people who follow the Western diet with high amounts of saturated fat and trans fat, red meat, processed food, and less nuts, fruits, and vegetables are at higher risk of abnormally high blood cholesterol.
In other words, patients with hyperlipidemia may lower their blood cholesterol with a change of diet pattern and active lifestyle.
Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asia and Europe.
In the reaffirm of the effect a diet rich in fruit and vegetables can protect against cardiovascular diseases by acting on cholesterol metabolism and oxidative stress, researchers launched an investigation to examine whether daily carrot consumption (provided as lyophilized powder) could differentially influence the consequences of cholesterol supplementation on lipid metabolism and oxidative stress in C57BL/6J mice.
14 mice were randomized into four groups. Mice were fed either control diets (without or with 0.25% cholesterol added) or lyophilized carrot-enriched diets (20% wt/wt without or with 0.25 % cholesterol added) for 4 weeks.
At the end of the study, researchers found.
* Carrot included in the diet mice group shows a decrease of cholesterol by 41% and triglycerides by 49 % in plasma and in the liver, by 41% and -39%, respectively in animals fed cholesterol-supplemented diets.
* Carrot-fed mice group also induced an increase of total neutral sterols fecal excretion, which inhibits digestive cholesterol absorption.
* Carrot diet increased antioxidant status in cholesterol-fed mice as related by the 16% higher FRAP values.
* Although vitamin E was not affected by the carrot diet, the vitamin E/TG ratio was significantly higher in animals fed carrot diets. By comparison to the healthy mice, the dyslipidaemic mice had higher serum vitamin E (p<0.001), but the serum vitamin E / total cholesterol ratio did not differ between the dyslipidaemic mice and healthy controls (p>0.05)
Further differentiation also suggested that The carrot diet protects the heart tissue through the expression of an increase of vitamin E in the heart in both cholesterol-free and cholesterol-supplemented mice.
Dr. Nicolle C, the lead author after taking into account co and confounders said, "Carrot ingestion decreases lipemia and improves antioxidant status in mice".
These results indicated a protective impact against CVD linked to atherosclerosis by regular intake of carrot diet and these effects were attributed to the synergistic effect of fiber and associated antioxidants.
Additionally, in the examination of the vegetable's major dietary sources of fibers and antioxidants such as carotenoids, polyphenols, and vitamin C in the contribution to the protective effects against cardiovascular diseases, researchers conducted a study in the rat model to test the effects of a 3-week supplementation of the diet with carrot (15% dry matter) on lipid metabolism and antioxidant status.
In the final report of the experiment, researchers showed
* Carrot intake significantly decreases cholesterol level in the liver by 44% and level of liver triglycerides by 40%.
* Carrot diet increases the fecal total steroid excretion increased by 30% in the carrot diet compared to the control, an indication of reduced cholesterol absorption.
* The secretion of bile acids was maintained, whereas the cholesterol apparent absorption was reduced in rats fed with a carrot diet.
* Carrot consumption also improves the antioxidant status
* The carrot diet provided carotenoid antioxidants: 5.1 mg beta-carotene, 1.6 mg alpha-carotene, and 0.25mg lutein per 100 g diet.
Dr. Nicolle C the lead author in the summary once again said, " Carrot consumption modifies cholesterol absorption and bile acids excretion and increases antioxidant status and these effects could be interesting for cardiovascular protection".
Taken together, there is no doubt that carrots with abundant antioxidants may be considered a functional food and an adjunct therapy for the prevention and treatment of patients with hyperlipidemia.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lyophilized carrot ingestion lowers lipemia and beneficially affects cholesterol metabolism in cholesterol-fed C57BL/6J mice by Nicolle C1, Gueux E, Lab C, Jaffrelo L, Rock E, Mazur A, Amouroux P, Rémésy C.(PubMed)
(2) Effect of carrot intake on cholesterol metabolism and on antioxidant status in the cholesterol-fed rat by Nicolle C1, Cardinault N, Aprikian O, Busserolles J, Grolier P, Rock E, Demigné C, Mazur A, Scalbert A, Amouroux P, Rémésy C.(PubMed)
Carrots may have found a therapeutic and positive effect in inhibiting the abnormally high blood cholesterol some scientists suggested.
Hyperlipidemia is a condition characterized by abnormally high blood cholesterol in the blood.
The exact causes of the condition are unknown. However, most researchers suggested that genetic mutation inherited from the parents, unhealthy diet and lifestyle, and some medical conditions such as diabetes, kidney disease, and hypothyroidism, are the most common risk factors that cause the early onset of the syndrome.
Truly, mutation of the LDLRAP1 gene is inherited in an autosomal recessive pattern which contributes to the risk of hyperlipidemia. However, parents of the patient who carry only one copy of the altered gene, are not at risk of high blood cholesterol levels.
Dr. GS Mannu,, the lead author in the study "Evidence of Lifestyle Modification in the Management of Hypercholesterolemia" said, "Target cholesterol levels set out in various guidelines could be achieved by lifestyle changes, including diet, weight reduction, and increased physical activity with the goal of reducing total cholesterol to <200 mg/dL and LDL-C <100mg/dL. Various dietary constituents such as green tea, plant sterols, and soy protein have important influences on total cholesterol. Medical intervention should be reserved for those patients who have not reached this goal after 3 months of non-pharmacological approach".
This statement indicates people who follow the Western diet with high amounts of saturated fat and trans fat, red meat, processed food, and less nuts, fruits, and vegetables are at higher risk of abnormally high blood cholesterol.
In other words, patients with hyperlipidemia may lower their blood cholesterol with a change of diet pattern and active lifestyle.
Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asia and Europe.
In the reaffirm of the effect a diet rich in fruit and vegetables can protect against cardiovascular diseases by acting on cholesterol metabolism and oxidative stress, researchers launched an investigation to examine whether daily carrot consumption (provided as lyophilized powder) could differentially influence the consequences of cholesterol supplementation on lipid metabolism and oxidative stress in C57BL/6J mice.
14 mice were randomized into four groups. Mice were fed either control diets (without or with 0.25% cholesterol added) or lyophilized carrot-enriched diets (20% wt/wt without or with 0.25 % cholesterol added) for 4 weeks.
At the end of the study, researchers found.
* Carrot included in the diet mice group shows a decrease of cholesterol by 41% and triglycerides by 49 % in plasma and in the liver, by 41% and -39%, respectively in animals fed cholesterol-supplemented diets.
* Carrot-fed mice group also induced an increase of total neutral sterols fecal excretion, which inhibits digestive cholesterol absorption.
* Carrot diet increased antioxidant status in cholesterol-fed mice as related by the 16% higher FRAP values.
* Although vitamin E was not affected by the carrot diet, the vitamin E/TG ratio was significantly higher in animals fed carrot diets. By comparison to the healthy mice, the dyslipidaemic mice had higher serum vitamin E (p<0.001), but the serum vitamin E / total cholesterol ratio did not differ between the dyslipidaemic mice and healthy controls (p>0.05)
Further differentiation also suggested that The carrot diet protects the heart tissue through the expression of an increase of vitamin E in the heart in both cholesterol-free and cholesterol-supplemented mice.
Dr. Nicolle C, the lead author after taking into account co and confounders said, "Carrot ingestion decreases lipemia and improves antioxidant status in mice".
These results indicated a protective impact against CVD linked to atherosclerosis by regular intake of carrot diet and these effects were attributed to the synergistic effect of fiber and associated antioxidants.
Additionally, in the examination of the vegetable's major dietary sources of fibers and antioxidants such as carotenoids, polyphenols, and vitamin C in the contribution to the protective effects against cardiovascular diseases, researchers conducted a study in the rat model to test the effects of a 3-week supplementation of the diet with carrot (15% dry matter) on lipid metabolism and antioxidant status.
In the final report of the experiment, researchers showed
* Carrot intake significantly decreases cholesterol level in the liver by 44% and level of liver triglycerides by 40%.
* Carrot diet increases the fecal total steroid excretion increased by 30% in the carrot diet compared to the control, an indication of reduced cholesterol absorption.
* The secretion of bile acids was maintained, whereas the cholesterol apparent absorption was reduced in rats fed with a carrot diet.
* Carrot consumption also improves the antioxidant status
* The carrot diet provided carotenoid antioxidants: 5.1 mg beta-carotene, 1.6 mg alpha-carotene, and 0.25mg lutein per 100 g diet.
Dr. Nicolle C the lead author in the summary once again said, " Carrot consumption modifies cholesterol absorption and bile acids excretion and increases antioxidant status and these effects could be interesting for cardiovascular protection".
Taken together, there is no doubt that carrots with abundant antioxidants may be considered a functional food and an adjunct therapy for the prevention and treatment of patients with hyperlipidemia.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lyophilized carrot ingestion lowers lipemia and beneficially affects cholesterol metabolism in cholesterol-fed C57BL/6J mice by Nicolle C1, Gueux E, Lab C, Jaffrelo L, Rock E, Mazur A, Amouroux P, Rémésy C.(PubMed)
(2) Effect of carrot intake on cholesterol metabolism and on antioxidant status in the cholesterol-fed rat by Nicolle C1, Cardinault N, Aprikian O, Busserolles J, Grolier P, Rock E, Demigné C, Mazur A, Scalbert A, Amouroux P, Rémésy C.(PubMed)
Intake of #Onion Daily and Regularly Are Inversely Associated with a Reduced Risk of Numbers of Cancer, Scientists Show
Kyle J. Norton
Cancer is a group of medical conditions caused by irregular cell growth in the tissues and organs due to the alternation of cell DNA.
Most cases of cancer start in the cells on the surface of the inner lining of the infected tissue or argan before penetrating into the deeper layers to form a tumor.
Certain factors have been found to affect prognosis including
* The type of cancer and where it is in your body
*The stage of cancer, most often refers to the size and metastasis of cancer.
** Stage 0
Cancer is classified as Stage 0 if the cancerous cell has not penetrated in deeper tissue but on the surface of the inner lining.
** Stage I
In stage I, The cancerous cells are no longer in the surface but have invaded into deep lung lining, but still completely inside the lung.
***Stage IA1
The cancer is ≤ 3 mm (1/8 inch) deep and ≤ 7 mm (1/4 inch) wide.
**** Stage IA1: The spreading is < 3mm(1/8 inch) deep and & less than 7mm (1/4 inch) wide.
**** Stage IA2: The invasion area is ≥ 3 mm but ≤ 5 mm (about 1/5 inch) deep and & less than 7 mm (about 1/4 inch) wide.
***. Stage IB: cancer in this stage have invaded the connective tissue, & less than 5mm (1/5 inch).
**** Stage IB1: Cancer is 4 cm large (1 3/4 inches).
**** Stage IB2: Cancer is ≥ 4 cm (1 3/4 inches) but & less than 5cm (1/5 inch)
**Stage II
In stage II, the cancerous cells have spread to distant tissues but are still within the organ.
**Stage III
this stage, cancerous cells have spread to the tissues immediately surrounding the organ.
**Stage IV
In the stage, IV is the most advanced stage of cancer as cancerous cells have spread to the distant parts of the body
In this stage, cancerous cells have spread to the tissues immediately surrounding the organ.
* Cancer’s grade, low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.
* Certain traits of cancer cells include
** How cancer cell stimulates their own growth
** How cancer cells resist inhibitory signals that stop their growth
** How cancer cells inhibit programmed cell death signaling.
Some researchers also include the age, health of patients and how patients responded to previous cancer treatment
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
With an aim to find a potential compound for the treatment of cancer, researchers examined the effect of garlic and onion on certain types of cancer.
Intake of onion is found inversely associated with the risk of onions or garlic and cancers of the oral cavity/pharynx, larynx, renal cells, breast, ovary, and endometrium.
More precisely, people who eat onions ≥7 times/week have the OR of oral cavity/pharyngeal cancers of 0.16, laryngeal cancer of 0.17, and ovarian cancer of 0.27 compared to those who did not eat onions.
Furthermore, according to the study of cases from the Hawaii Tumor Registry and controls randomly selected from a list of Oahu residents, intake of onion was associated with decreased risk of lung cancer with the OR = 0.5 in the highest quartile of intake compared to the lowest.
In prostate cancer, the Italian study suggested that both onions and garlic did not have significantly decreased OR of prostate cancer compared to those with the lowest intake, However, increasing intake showed a trend of decreasing the ORs.
In esophageal cancer, the intake of raw garlic/onion at least one time per week has the adjusted OR of esophageal cancer of 0.2.
In colorectal cancer, the Italian and Swiss case-control studies found that both onions show a protective effect against colon cancer regardless of the amount of intake onion intake compared to non-consumers of onion.
In stomach cancer, according to the meta-analysis, consumption of large amounts of total Allium vegetables, such as garlic and onion reduced the risk of gastric cancer by comparing the highest and lowest consumption groups.
Taken together, onion may be considered a remedy for the prevention of cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)
(2) Understanding Cancer Prognosis (NIH)
Cancer is a group of medical conditions caused by irregular cell growth in the tissues and organs due to the alternation of cell DNA.
Most cases of cancer start in the cells on the surface of the inner lining of the infected tissue or argan before penetrating into the deeper layers to form a tumor.
Certain factors have been found to affect prognosis including
* The type of cancer and where it is in your body
*The stage of cancer, most often refers to the size and metastasis of cancer.
** Stage 0
Cancer is classified as Stage 0 if the cancerous cell has not penetrated in deeper tissue but on the surface of the inner lining.
** Stage I
In stage I, The cancerous cells are no longer in the surface but have invaded into deep lung lining, but still completely inside the lung.
***Stage IA1
The cancer is ≤ 3 mm (1/8 inch) deep and ≤ 7 mm (1/4 inch) wide.
**** Stage IA1: The spreading is < 3mm(1/8 inch) deep and & less than 7mm (1/4 inch) wide.
**** Stage IA2: The invasion area is ≥ 3 mm but ≤ 5 mm (about 1/5 inch) deep and & less than 7 mm (about 1/4 inch) wide.
***. Stage IB: cancer in this stage have invaded the connective tissue, & less than 5mm (1/5 inch).
**** Stage IB1: Cancer is 4 cm large (1 3/4 inches).
**** Stage IB2: Cancer is ≥ 4 cm (1 3/4 inches) but & less than 5cm (1/5 inch)
**Stage II
In stage II, the cancerous cells have spread to distant tissues but are still within the organ.
**Stage III
this stage, cancerous cells have spread to the tissues immediately surrounding the organ.
**Stage IV
In the stage, IV is the most advanced stage of cancer as cancerous cells have spread to the distant parts of the body
In this stage, cancerous cells have spread to the tissues immediately surrounding the organ.
* Cancer’s grade, low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.
* Certain traits of cancer cells include
** How cancer cell stimulates their own growth
** How cancer cells resist inhibitory signals that stop their growth
** How cancer cells inhibit programmed cell death signaling.
Some researchers also include the age, health of patients and how patients responded to previous cancer treatment
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
With an aim to find a potential compound for the treatment of cancer, researchers examined the effect of garlic and onion on certain types of cancer.
Intake of onion is found inversely associated with the risk of onions or garlic and cancers of the oral cavity/pharynx, larynx, renal cells, breast, ovary, and endometrium.
More precisely, people who eat onions ≥7 times/week have the OR of oral cavity/pharyngeal cancers of 0.16, laryngeal cancer of 0.17, and ovarian cancer of 0.27 compared to those who did not eat onions.
Furthermore, according to the study of cases from the Hawaii Tumor Registry and controls randomly selected from a list of Oahu residents, intake of onion was associated with decreased risk of lung cancer with the OR = 0.5 in the highest quartile of intake compared to the lowest.
In prostate cancer, the Italian study suggested that both onions and garlic did not have significantly decreased OR of prostate cancer compared to those with the lowest intake, However, increasing intake showed a trend of decreasing the ORs.
In esophageal cancer, the intake of raw garlic/onion at least one time per week has the adjusted OR of esophageal cancer of 0.2.
In colorectal cancer, the Italian and Swiss case-control studies found that both onions show a protective effect against colon cancer regardless of the amount of intake onion intake compared to non-consumers of onion.
In stomach cancer, according to the meta-analysis, consumption of large amounts of total Allium vegetables, such as garlic and onion reduced the risk of gastric cancer by comparing the highest and lowest consumption groups.
Taken together, onion may be considered a remedy for the prevention of cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)
(2) Understanding Cancer Prognosis (NIH)
#Ginger Exerts a Significant Bacterial and Fungal Infection Activities, Researchers Say
Kyle J. Norton
Scientists may have found a pungent spice that processes the potential to inhibit microbial infection, according to studies.
Microbial infection is an infection caused by the multiplication of microbes after entering the body successfully.
The process of infection can be divided into many stages. However, most microbes try to invade the body are killed in the acute phase of infection by the immune system response through the production of the protein associated with the pro-inflammatory cytokines.
Most people do not experience any symptoms until the microbe multiplication to the peak in its population.
Acute infection in most cases is recovered within a week or two. However, if the immune function cannot destroy all the microbes within a certain period of time, it will adapt to the new change, leading to chronic low-grade inflammatory diseases.
The chronic low-grade inflammatory state is a pathological feature of a wide range of chronic conditions, such as metabolic syndrome (MetS), non-alcoholic fatty liver disease (NAFLD), and type 2 diabetes.
The most common risk of microbial infection is a weakened immune system, particularly in the elderly.
The Institute of Medicine (US) Division of Health Promotion and Disease Prevention in examining the risk of infection in the elderly, wrote, "The implications of an aging population for health care are being widely discussed but seldom with the understanding that health promotion and disability prevention are workable concepts for people in the “second 50” years of life".
And, "Pneumonia and influenza are among the leading causes of death and morbidity from infection among older people. Safe and effective vaccines to prevent pneumonia and influenza are available and should be universally used in persons over age 50. Nosocomial (institutionally acquired) infections have a major deleterious impact on persons over 50 and require good infection control practices in hospitals and nursing homes".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers to find a natural alternative for the treatment of bacterial infection examined the ginger's antimicrobial and antifungal properties associated with periodontitis in the human oral cavity
The application of ethanol and n-hexane extracts of ginger exhibited antibacterial activities that cause periodontal diseases. against three anaerobic Gram-negative bacteria, Porphyromonas gingivalis ATCC 53978, Porphyromonas endodontalis ATCC 35406, and Prevotella intermedia ATCC 25611.
Two highly alkylated gingerols, such as [10]-gingerol and [12]-gingerol effectively inhibited the growth of these oral pathogens at a minimum inhibitory concentration (MIC) range of 6-30 microg/mL.
Furthermore, these 2 compounds also killed the oral pathogens at a minimum bactericidal concentration (MBC) range of 4-20 microg/mL compared to other failed compounds such as 5-acetoxy-[6]-gingerol, 3,5-diacetoxy-[6]-gingerdiol and galanolactone.
In order to reveal more information about ginger's antimicrobial activity, researchers examine the newly isolated compounds including 6-paradol (1) and 6-shogaol (2) as the major antimycobacterial agents.
Injection of these isolates was found to be active against Mycobacterium chelonei, M. intracellulare, M. smegmatis, and M. xenopi (MIC 10-15 µg/ml).
The desmethyl derivative of compound (1) retained the antimycobacterial activity. However, derivatives are more active against Candida albicans, compared to (1) and (2).
Interestingly, the new compound Gingerone (9)was found to be inactive against microbial activity.
Taken together, ginger processed with abundantly bioactive ingredients may be considered a natural alternative for the prevention and treatment of microbial infection, and diseases associated with microbacterial infectious disease, pending the confirmation of a larger sample size and multicenter human infection.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteria by Park M1, Bae J, Lee DS.(PubMed)
(2) Antimicrobial Activity of 6-Paradol and Related Compounds by Ahmed M Galal. (Journal, International Journal of Pharmacognosy)
(3) The Second Fifty Years: Promoting Health and Preventing Disability by The Institute of Medicine (US) Division of Health Promotion and Disease Prevention
Scientists may have found a pungent spice that processes the potential to inhibit microbial infection, according to studies.
Microbial infection is an infection caused by the multiplication of microbes after entering the body successfully.
The process of infection can be divided into many stages. However, most microbes try to invade the body are killed in the acute phase of infection by the immune system response through the production of the protein associated with the pro-inflammatory cytokines.
Most people do not experience any symptoms until the microbe multiplication to the peak in its population.
Acute infection in most cases is recovered within a week or two. However, if the immune function cannot destroy all the microbes within a certain period of time, it will adapt to the new change, leading to chronic low-grade inflammatory diseases.
The chronic low-grade inflammatory state is a pathological feature of a wide range of chronic conditions, such as metabolic syndrome (MetS), non-alcoholic fatty liver disease (NAFLD), and type 2 diabetes.
The most common risk of microbial infection is a weakened immune system, particularly in the elderly.
The Institute of Medicine (US) Division of Health Promotion and Disease Prevention in examining the risk of infection in the elderly, wrote, "The implications of an aging population for health care are being widely discussed but seldom with the understanding that health promotion and disability prevention are workable concepts for people in the “second 50” years of life".
And, "Pneumonia and influenza are among the leading causes of death and morbidity from infection among older people. Safe and effective vaccines to prevent pneumonia and influenza are available and should be universally used in persons over age 50. Nosocomial (institutionally acquired) infections have a major deleterious impact on persons over 50 and require good infection control practices in hospitals and nursing homes".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers to find a natural alternative for the treatment of bacterial infection examined the ginger's antimicrobial and antifungal properties associated with periodontitis in the human oral cavity
The application of ethanol and n-hexane extracts of ginger exhibited antibacterial activities that cause periodontal diseases. against three anaerobic Gram-negative bacteria, Porphyromonas gingivalis ATCC 53978, Porphyromonas endodontalis ATCC 35406, and Prevotella intermedia ATCC 25611.
Two highly alkylated gingerols, such as [10]-gingerol and [12]-gingerol effectively inhibited the growth of these oral pathogens at a minimum inhibitory concentration (MIC) range of 6-30 microg/mL.
Furthermore, these 2 compounds also killed the oral pathogens at a minimum bactericidal concentration (MBC) range of 4-20 microg/mL compared to other failed compounds such as 5-acetoxy-[6]-gingerol, 3,5-diacetoxy-[6]-gingerdiol and galanolactone.
In order to reveal more information about ginger's antimicrobial activity, researchers examine the newly isolated compounds including 6-paradol (1) and 6-shogaol (2) as the major antimycobacterial agents.
Injection of these isolates was found to be active against Mycobacterium chelonei, M. intracellulare, M. smegmatis, and M. xenopi (MIC 10-15 µg/ml).
The desmethyl derivative of compound (1) retained the antimycobacterial activity. However, derivatives are more active against Candida albicans, compared to (1) and (2).
Interestingly, the new compound Gingerone (9)was found to be inactive against microbial activity.
Taken together, ginger processed with abundantly bioactive ingredients may be considered a natural alternative for the prevention and treatment of microbial infection, and diseases associated with microbacterial infectious disease, pending the confirmation of a larger sample size and multicenter human infection.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteria by Park M1, Bae J, Lee DS.(PubMed)
(2) Antimicrobial Activity of 6-Paradol and Related Compounds by Ahmed M Galal. (Journal, International Journal of Pharmacognosy)
(3) The Second Fifty Years: Promoting Health and Preventing Disability by The Institute of Medicine (US) Division of Health Promotion and Disease Prevention
#ManukaHoney's Methylglyoxal (MGO) Processes a Strong Anti-influenza Property, Researchers Suggest
Kyle J. Norton
Honey may have a profound effect in reducing the risk and treatment of influenza, some scientists suggested.
Influenza, also known as the flu, is an infectious disease caused by an influenza virus.
There are 3 types of flu influenza: A, B, and C. The influenza virus A and B are considered seasonal flu that causes sniffling, aching, coughing, running and stuffy nose, and fever to over 20% of the general population.
Influenza virus type C tends to cause mild upper respiratory infections, similar to those of colds.
Healthy individuals who have influenza are usually recovered within one week.
However, people with immature and weakened immune systems such as young children under age 5, adults older than age 65 residents of nursing homes and other long-term care facilities, and chronic illnesses, such as asthma, heart disease, kidney disease, liver disease, and diabetes are not only associated with the risk of influenza but also increase the risk of influenza deadly complication.
Pregnant women and women up to two weeks postpartum due to changes in the immune system and other organs have been found to make a woman more prone to influenza and influenza complications.
Some researchers also suggested that obese people are also at a higher risk of the onset of influenza.
Dr. Green WD, the lead author at the University of North Carolina at Chapel Hill suggested that obese individuals associated with the impairment of the adaptive immune response are at substantial risk of influenza.
The doctor team in the study " Obesity Impairs the Adaptive Immune Response to Influenza Virus" wrote, "Given the dramatic rise in obesity over the past few decades, this increased risk for influenza infection poses a serious public health threat because nearly 500 million adults and children worldwide are classified as obese".
"Obesity impairs the immune response to influenza and influenza vaccination through alterations of the cellular immune system. Compared with vaccinated healthy-weight adults, vaccinated obese adults have twice the risk of influenza or influenza-like illness despite equal serological response to vaccination".
The most common symptoms of influenza are high fever, runny nose, sore throat, muscle pains, headache, coughing, sneezing, and persistent fatigue.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of the healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.
In finding a natural ingredient and whole food for the prevention and treatment of influenza, researchers at a joint study led by Nagasaki University the antiviral activities of honey samples using MDCK cells.
Application of Manuka honey efficiently inhibited influenza virus replication which is related to its virucidal effects.
Manuka honey at the dose of 3.13 mg/mL also improved the function of zanamivir or oseltamivir by reducing the maximum concentration of effectiveness to nearly 1/1000th for their single use.
Dr.Watanabe K, the lead scientist said, "Honey, in general, and particularly Manuka honey, has potent inhibitory activity against the influenza virus, demonstrating a potential medicinal value.
Moreover, by re-examining the anti-influenza effect of Luatang honey, researchers suspected that the efficacy may be associated with the presence of the methylglyoxal (MGO), a key component of Manuka honey.
By evaluating the anti-influenza viral activity of MGO and its potential in combination treatments with neuraminidase (NA) inhibitors, researchers found that
* Injection of MGO inhibited influenza virus A/WSN/33 replication 50% inhibitory concentration = 240 ± 190 μM; 50% cytotoxic concentration = 1.4 ± 0.4 mM; selective index (SI) = 5.8, which is related to its virucidal effects.
* MGO exerted a promising activity against various influenza strains.
* MGO increases the effect of NA inhibitors by decreasing the to ∼1/100(th) of their single usage.
* MGO also demonstrates a synergistic effect with NA inhibitor against the oseltamivir-resistant virus.
Taken together, Luatang honey processed bioactive compound methylglyoxal (MGO) may be considered a functional food for the prevention and combined with primary therapy for the treatment of influenza with no side effects, pending a larger and multi-center human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Anti-influenza viral effects of honey in vitro: potent high activity of manuka honey by Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N3.(PubMed)
(2) In vitro evaluation of synergistic inhibitory effects of neuraminidase inhibitors and methylglyoxal against influenza virus infection by Charyasriwong S1, Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N3. (PubMed)
(3) Obesity Impairs the Adaptive Immune Response to Influenza Virus by Green WD1, Beck MA. (PubMed).
Honey may have a profound effect in reducing the risk and treatment of influenza, some scientists suggested.
Influenza, also known as the flu, is an infectious disease caused by an influenza virus.
There are 3 types of flu influenza: A, B, and C. The influenza virus A and B are considered seasonal flu that causes sniffling, aching, coughing, running and stuffy nose, and fever to over 20% of the general population.
Influenza virus type C tends to cause mild upper respiratory infections, similar to those of colds.
Healthy individuals who have influenza are usually recovered within one week.
However, people with immature and weakened immune systems such as young children under age 5, adults older than age 65 residents of nursing homes and other long-term care facilities, and chronic illnesses, such as asthma, heart disease, kidney disease, liver disease, and diabetes are not only associated with the risk of influenza but also increase the risk of influenza deadly complication.
Pregnant women and women up to two weeks postpartum due to changes in the immune system and other organs have been found to make a woman more prone to influenza and influenza complications.
Some researchers also suggested that obese people are also at a higher risk of the onset of influenza.
Dr. Green WD, the lead author at the University of North Carolina at Chapel Hill suggested that obese individuals associated with the impairment of the adaptive immune response are at substantial risk of influenza.
The doctor team in the study " Obesity Impairs the Adaptive Immune Response to Influenza Virus" wrote, "Given the dramatic rise in obesity over the past few decades, this increased risk for influenza infection poses a serious public health threat because nearly 500 million adults and children worldwide are classified as obese".
"Obesity impairs the immune response to influenza and influenza vaccination through alterations of the cellular immune system. Compared with vaccinated healthy-weight adults, vaccinated obese adults have twice the risk of influenza or influenza-like illness despite equal serological response to vaccination".
The most common symptoms of influenza are high fever, runny nose, sore throat, muscle pains, headache, coughing, sneezing, and persistent fatigue.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of the healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.
In finding a natural ingredient and whole food for the prevention and treatment of influenza, researchers at a joint study led by Nagasaki University the antiviral activities of honey samples using MDCK cells.
Application of Manuka honey efficiently inhibited influenza virus replication which is related to its virucidal effects.
Manuka honey at the dose of 3.13 mg/mL also improved the function of zanamivir or oseltamivir by reducing the maximum concentration of effectiveness to nearly 1/1000th for their single use.
Dr.Watanabe K, the lead scientist said, "Honey, in general, and particularly Manuka honey, has potent inhibitory activity against the influenza virus, demonstrating a potential medicinal value.
Moreover, by re-examining the anti-influenza effect of Luatang honey, researchers suspected that the efficacy may be associated with the presence of the methylglyoxal (MGO), a key component of Manuka honey.
By evaluating the anti-influenza viral activity of MGO and its potential in combination treatments with neuraminidase (NA) inhibitors, researchers found that
* Injection of MGO inhibited influenza virus A/WSN/33 replication 50% inhibitory concentration = 240 ± 190 μM; 50% cytotoxic concentration = 1.4 ± 0.4 mM; selective index (SI) = 5.8, which is related to its virucidal effects.
* MGO exerted a promising activity against various influenza strains.
* MGO increases the effect of NA inhibitors by decreasing the to ∼1/100(th) of their single usage.
* MGO also demonstrates a synergistic effect with NA inhibitor against the oseltamivir-resistant virus.
Taken together, Luatang honey processed bioactive compound methylglyoxal (MGO) may be considered a functional food for the prevention and combined with primary therapy for the treatment of influenza with no side effects, pending a larger and multi-center human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Anti-influenza viral effects of honey in vitro: potent high activity of manuka honey by Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N3.(PubMed)
(2) In vitro evaluation of synergistic inhibitory effects of neuraminidase inhibitors and methylglyoxal against influenza virus infection by Charyasriwong S1, Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N3. (PubMed)
(3) Obesity Impairs the Adaptive Immune Response to Influenza Virus by Green WD1, Beck MA. (PubMed).
#Herbal #Ashwagandha Improves Nonrestorative Sleep, Insomnia and Stress-Induced Depression.and Inhibits -Anxiety, According to Clinical Trials
Kyle J. Norton
Why sleep is so important? you might already know that a normal night of sleep is about eight hours as recommended by most doctors.
It is important, because during sleep our bodies repair the wear and tear of muscle tissue, consolidate memories, and release hormones to regulate our growth and appetites and enhance the immune system, etc. sleep disorders can reduce the functions of the immune system in fighting against disease and sickness.
Nonrestorative sleep (NRS) is a condition in which the sleep has not been sufficiently refreshing or restorative upon waking, despite sleeping an adequate number of hours, accompanied by daytime impairment, pain, fatigue, and electroencephalogram (EEG) arousals in non-REM sleep in some patients.
In other words, NRS is a peripheral symptom of insomnia or a feature of medical conditions like fibromyalgia and chronic fatigue syndrome.
* Insomnia
Insomnia is a sign and symptom of sleep disorder in which a person has difficulty falling asleep and/or staying asleep or sleep of poor quality, including nonrestorative sleep, which can lead to substantial impairments in the quality of life and functional capacity of an individual.
Most adults have experienced insomnia sometimes in their lives. According to statistics, more than 30% of the population suffers from insomnia, one in three people suffer from some form of insomnia during their lifetime, and women suffer from insomnia more often than men.
* Fibromyalgia
Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.
* Chronic fatigue syndrome
Chronic fatigue syndrome (CFS) is a medical disorder that cannot be explained by an underlying medical condition, characterized by persistently extreme fatigue that never goes away regardless of treatment for at least 6 months.
The exact causes of chronic fatigue syndrome are unknown. However, some researchers suggested that the conditions are the results of viral infection and chronic stress syndrome.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the treatment of sleep disorders, researchers examined the effects of Ashwagandha (Withania somnifera) on patients with nonrestorative sleep (NRS).
According to the Restorative Sleep Questionnaire-weekly version (RSQ-W) questionnaire and other test assays, in a double-blind, randomized, placebo-controlled interventional study in the NRS population, a daily supplement of ashwagandha extract compared with placebo in subjects with NRS at 6 weeks from baseline,
* Exerted Anti-anxiety effects.
* Relieved insomnia and stress-induced depression.
* Reduced cortisol concentrations and the immunosuppressive effect of stress.
* Lowered CRP by inhibiting the expression of pro-inflammatory responses in the body.
Taken together, Ashwagandha may be considered a therapy for the treatment of nonrestorative sleep (NRS), pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Study protocol and rationale for a prospective, randomized, double-blind, placebo-controlled study to evaluate the effects of Ashwagandha (Withaniasomnifera) extract on nonrestorative sleep by Deshpande A, Irani N, Balakrishnan R. (PubMed)
Why sleep is so important? you might already know that a normal night of sleep is about eight hours as recommended by most doctors.
It is important, because during sleep our bodies repair the wear and tear of muscle tissue, consolidate memories, and release hormones to regulate our growth and appetites and enhance the immune system, etc. sleep disorders can reduce the functions of the immune system in fighting against disease and sickness.
Nonrestorative sleep (NRS) is a condition in which the sleep has not been sufficiently refreshing or restorative upon waking, despite sleeping an adequate number of hours, accompanied by daytime impairment, pain, fatigue, and electroencephalogram (EEG) arousals in non-REM sleep in some patients.
In other words, NRS is a peripheral symptom of insomnia or a feature of medical conditions like fibromyalgia and chronic fatigue syndrome.
* Insomnia
Insomnia is a sign and symptom of sleep disorder in which a person has difficulty falling asleep and/or staying asleep or sleep of poor quality, including nonrestorative sleep, which can lead to substantial impairments in the quality of life and functional capacity of an individual.
Most adults have experienced insomnia sometimes in their lives. According to statistics, more than 30% of the population suffers from insomnia, one in three people suffer from some form of insomnia during their lifetime, and women suffer from insomnia more often than men.
* Fibromyalgia
Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.
* Chronic fatigue syndrome
Chronic fatigue syndrome (CFS) is a medical disorder that cannot be explained by an underlying medical condition, characterized by persistently extreme fatigue that never goes away regardless of treatment for at least 6 months.
The exact causes of chronic fatigue syndrome are unknown. However, some researchers suggested that the conditions are the results of viral infection and chronic stress syndrome.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the treatment of sleep disorders, researchers examined the effects of Ashwagandha (Withania somnifera) on patients with nonrestorative sleep (NRS).
According to the Restorative Sleep Questionnaire-weekly version (RSQ-W) questionnaire and other test assays, in a double-blind, randomized, placebo-controlled interventional study in the NRS population, a daily supplement of ashwagandha extract compared with placebo in subjects with NRS at 6 weeks from baseline,
* Exerted Anti-anxiety effects.
* Relieved insomnia and stress-induced depression.
* Reduced cortisol concentrations and the immunosuppressive effect of stress.
* Lowered CRP by inhibiting the expression of pro-inflammatory responses in the body.
Taken together, Ashwagandha may be considered a therapy for the treatment of nonrestorative sleep (NRS), pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Study protocol and rationale for a prospective, randomized, double-blind, placebo-controlled study to evaluate the effects of Ashwagandha (Withaniasomnifera) extract on nonrestorative sleep by Deshpande A, Irani N, Balakrishnan R. (PubMed)
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