#Phytochemical #Betanin Protects the Liver Against Toxicity, Researchers Suggest

Kyle J. Norton

Liver injury may be a result caused by physical impact or penetrating trauma. In some cases, liver injury can also be induced by toxicity, leading to acute liver injury.

Liver injury can be mild or severe. In a mild case, liver injury can recover itself. However, in severe cases. surgery to stop the bleeding and remove the part of the injury may be necessary.

Most cases of liver injury can lead to abdominal pain and tenderness caused by bleeding blood in the abdomen that irritates the abdominal tissue.


The severity of a liver injury can be diagnosed by computed tomography (CT) or ultrasonography.


According to the statistics, liver injury has been found to constitute 5% of all traumas, making it the most common abdominal injury.

Liver injury can be classified by the liver injury scale, depending on the area of the damage
* Grade I <10% surface area < 1 cm in depth
* Grade II 10–50% surface area 1–3 cm
* Grade III >50% or >10 cm >3 cm
* Grade IV 25–75% of a hepatic lobe \
* Grade V >75% of a hepatic lobe
and grade VI Hepatic avulsion


In other words, based on the grade of liver injury, patients are either treated with nonoperative management and observation for full self-recovery or surgery.

Betanin is a Phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a natural compound for the protection of the liver against injury, researchers examined the protective effect of betanin against liver injury induced by carbon tetrachloride (CCl4) in common carp (Cyprinus carpio L.).

The study included fish treated with 1, 2, and 4 % betanin in fodder throughout the experiment for 20 days followed by intraperitoneally injected with 20 % (v/v in peanut oil) carbon tetrachloride (CCl4) at a volume of 0.5 mL/kg body weight.

Where carbon tetrachloride (CCl4) is a highly toxic liquid chemical.

Injection of CCL4, after 3 days showed liver histological damages accompanied by the induced liver CYP2E1 activity associated with some degrees of steatosis and increased serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT), the indication of oxidative stress.


Furthermore, CCL4 also induced liver damage expressed by the depletion of glycogen storage.

Compared with the CCl4 control group, the betanin-treated groups reduced CYP2E1 expression, decreased malondialdehyde level, and increased liver antioxidative capacity observed by the increased glutathione level and superoxide dismutase and catalase activities.

Moreover, the betanin-treated groups also increased liver glycogen storage, and reduced serum AST/ALT activities, with significant differences in the 2 and 4 % treatment groups.

These results suggested betanin processes liver protective effects against liver injury by restoring some levels of liver function through its antioxidant activity.

Dr. Han J, the lead scientist wrote in the final report, " Betanin attenuates CCl4-induced liver damage in common carp. Moreover, the inhibition of CYP2E1 activity and oxidative stress may have significant roles in the protective effect of betanin".

Taken altogether, betanin may be considered a supplement for the treatment of liver injury, pending to the confirmation of the larger sample size and multicenter human study.

Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Betanin attenuates carbon tetrachloride (CCl4)-induced liver injury in common carp (Cyprinus carpio L.) by Han J1, Gao C, Yang S, Wang J, Tan D. (PubMed)
(2) Betanin, a beetroot component, induces nuclear factor erythroid-2-related factor 2-mediated expression of detoxifying/antioxidant enzymes in human liver cell lines by Krajka-Kuźniak V1, Paluszczak J, Szaefer H, Baer-Dubowska W. (PubMed)

#Herbal #Turmeric Reduces Axillary Hair Growth, According to Studies

Kyle J. Norton

Unwanted hair growth or hirsutism in women is a medical condition of male-pattern hair growth a woman’s face, arms, back, or chest that is coarse and dark, compared to normal light facial and body hair.

Unwanted male hair growth in women is associated with the production of too much androgen hormone due to certain medical conditions such as polycystic ovarian syndrome (PCOS) and adrenal gland disorders.

Conventionally, Minoxidil, a topical medicine approved by the U.S. Food and Drug Administration (FDA) was found to stop hairs from getting thinner and stimulate hair growth on the top of the scalp. It has been found to induce excessive body or facial hair growth in women.

Other medications that treat testosterone deficiency such as anabolic steroids and immunosuppression also have been found to cause unwanted hair growth.

According to the statistics provided by the Carolina Skin, Laser & Research Centre, hirsutism affects around 5-10% of women. The syndrome is a common presenting complaint in the dermatological outpatient department (OPD) for cosmetic reasons.

Some researchers suggested that some people with severe metabolic syndrome may also experience a condition of hirsutism.

Believe it or not, hirsutism causes a huge psychosocial impact, particularly in the younger female.

Conventionally, the treatment of hirsutism is totally depending on the causes of the disease. for excessive androgen levels. Spironolactone (SPA), an androgen blocker can be used for binding to the androgen receptor and cyproterone Acetate (CA) to include progestogen and reduced androgen production.

In other treatments, Dr. Silonie Sachdeva suggested, "Hirustism requires in-depth clinical evaluation and investigation for treatment. For pharmacological therapy, oral contraceptives are recommended for the majority of women. Adding an antiandrogen may be needed after six months if the response is suboptimal. Antiandrogen monotherapy is not recommended unless adequate contraception is used. For women who choose hair removal therapy, photoexcitation with lasers is the preferred choice".


Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound for the promotion of hair growth, researchers examined the efficacy of a high sesquiterpene C. aeruginosa extract (CA-ext) in retarding axillary hair growth in women.

The 12 weeks of double-blind, placebo-controlled intervention for CA-ext treatment study included 30 women (age 20-52 years) who were recruited into a 12-week group and were randomly allocated to the left or right armpit group by applying lotion (to the contralateral axilla) twice daily via roll-on applicators containing either CA-ext or placebo after hair shaving.

Axillary hair length was measured video metrically at weekly intervals.

According to the results, lotion participants showed 22% (range 8-56%, p < 0.0001) reduced axillary hair growth with CA-ext compared to placebo.

At the end of the study, lotion group participants showed shorter and finer armpit hair compared to placebo.

Although there was no adverse effect reported by the lotion group, most participants disliked the smell.

Based on the findings, researchers said, "A-ext in lotion is an efficacious inhibitor of axillary hair growth, the preparation was well accepted and matched the effectiveness of finasteride".

Taken together, turmeric may be considered a supplement for preventing unwanted hair growth, pending confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sesquiterpene-Enriched Extract of Curcuma aeruginosa Roxb. Retards Axillary Hair Growth: A Randomised, Placebo-Controlled, Double-Blind Study by Srivilai J1, Nontakhot K1, Nutuan T1, Waranuch N2, Khorana N1, Wisuthiprot W3, Scholfield CN1, Champachaisri K4, Ingkaninan K. (PubMed)
(2) Germacrone and sesquiterpene-enriched extracts from Curcuma aeruginosa Roxb. increase skin penetration of minoxidil, a hair growth promoter by Srivilai J1, Waranuch N2, Tangsumranjit A2, Khorana N3, Ingkaninan K. (PubMed)
(3) HIRSUTISM: EVALUATION AND TREATMENT by Silonie Sachdeva (The Indian Journal of Dermatology)

#Artichoke Normalizes Blood Cholesterol as a Primary Prevention of #CardiovascularDisease, According to Studies

Kyle J. Norton

Cholesterol produced by the liver is needed for the cell to build strong membranes, produce steroid hormones, bile acids, and vitamin D, and aid digestive functioning.
Most people with high blood cholesterol at the early do not experience any symptoms, however, as the levels of blood cholesterol continue to grow, at some points, patients may experience heart-related symptoms, including chest pain or angina, pain while walking caused by reduced blood flow to the legs.

In serious cases, elevated blood cholesterol can also induce symptoms of stroke and heart attack.

Epidemiological studies suggest that a high level of blood cholesterol is associated with an increased risk of cardiovascular disease.

Besides a high-fat diet, certain risk factors such as a family history of high cholesterol, being overweight or obese, physical inactivity, excessive alcohol intake, smoking and some health conditions including diabetes, kidney disease, and liver disease have been found to increase the risk of high blood cholesterol.

There are 2 types of blood cholesterol
* Low-density lipoprotein (LDL) also is known as “bad cholesterol”. Bad cholesterol is a major cause of plaque build-up in the arteries if it presents at a high level.

*High-density lipoprotein (HDL) is known as “good cholesterol”. HDL helps remove LDL cholesterol from your arteries back to the liver.

The healthy ratio of blood cholesterol is 4 LDL)/ 1HLD

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Searching the list of combined nutraceuticals for the treatment of high blood cholesterol, researchers examined the effects of a combination of nutraceuticals based on artichoke, red yeast rice, banana, and coenzyme Q10.

The double bind, cross-over designed trial versus placebo included 30 adults with LDL cholesterol suboptimal in primary prevention of cardiovascular disease.

After a period of 3 weeks of dietary habits correction, patients began a period of 6 weeks of treatment with nutraceutical or placebo, followed by 2 weeks of washout and finally 6 weeks in cross-over.

The combination showed a significant improvement in total cholesterol (-13.6 %), LDL-C (-18.2 %), and non-HDL-C (-15 %).

Dr. Cicero AF said, "The tested combination of nutraceuticals has shown clinical efficacy in the reduction of total cholesterol, non-HDL, LDL, and triglycerides while improving the level of liver transaminases and high sensitivity C-reactive protein".

In order to reveal more information about artichoke anti-high blood cholesterol activity, researchers review selected studies according to the standard guidelines and criteria by searching the databases of medical literature.

The review of the meta-analysis of data from 9 trials including 702 subjects suggested that artichoke has a strong effect in decreasing plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, and triglycerides.

The application of artichoke has no effect on high-density lipoprotein concentration.

In other words, artichoke extract only had a significant reduction in both total and LDL-C, and triglycerides.

Taken together, artichoke may be considered a functional and herbal remedy for the treatment of high blood cholesterol with no side effects, pending the confirmation of a larger sample-sized and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effects of a Combined Nutraceutical on Lipid Pattern, Glucose Metabolism and Inflammatory Parameters in Moderately Hypercholesterolemic Subjects: A Double-blind, Cross-over, Randomized Clinical Trial by Cicero AF1,2, Colletti A3, Fogacci F3, Bove M3, Rosticci M3, Borghi C. (PubMed)
(2) Lipid-lowering activity of artichoke extracts: A systematic review and meta-analysis by Sahebkar A1, Pirro M2, Banach M3,4, Mikhailidis DP5, Atkin SL6, Cicero AFG. (PubMed)

#Phytochemical #Isothiocyanates Inhibit Diseases and Syndromes Associated with Oxidativestress Disorder, Researchers Show

Kyle J. Norton

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative, or zero charges. The unpaired electrons cause radicals to be highly chemically reactive in the human body, leading to aging and cancers.

In Fuchs endothelial corneal dystrophy (FECD), an oxidative stress disorder, treatment with Sulforaphane, a molecule within the isothiocyanate group, decreased CEC apoptosis by 55% in unstressed group and by 43% in tBHP-treated specimens, through inhibition of oxidative stress(1).
The Universidade Federal de Ouro Preto study also indicated a similar result of sulforaphane in the improvement of antioxidant status in the testing of a number of cancer cell lines(2). Another study suggested that isothiocyanates(ITCs), found abundantly in cruciferous vegetables, may be effective as a cancer chemopreventive agent through modulation of phase II detoxifying/antioxidant enzyme activities(3).

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Reference
(1) Sulforaphane decreases endothelial cell apoptosis in Fuchs endothelial corneal dystrophy: a novel treatment by Ziaei A1, Schmedt T, Chen Y, Jurkunas UV. (PubMed)
(2) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM1, Filho SA, Nogueira-Machado JA, Caligiorne RB. (PubMed)
(3) Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expression by Prawan A1, Keum YS, Khor TO, Yu S, Nair S, Li W, Hu L, Kong AN. (PubMed)

#Phytochemical #Carotenoids Inversely Are Associated with a Reduced Risk of #StomachCancer, Researchers Say

Kyle J. Norton

The stomach located between the esophagus and the small intestine is a muscular, hollow, and important organ of the digestive tract.
The stomach plays a critical role in assisting the digestive system in digesting foods by secreting acid and enzymes.
Gastric/Stomach cancer is a medical condition characterized by abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of gastric/stomach cancer.

According to the statistics, most cases of gastric/stomach cancer are found in older people. The average age of people when they are diagnosed is 68. The risk of developing gastric/stomach cancer in a man's lifetime is about 1 in 95.


The exact causes of gastric/stomach cancer are unidentified. However, researchers do not know that certain risk factors are associated with an increased risk of the disease, including
* Age

Most cases of gastric/stomach cancer are found in adults in their 50s.


*Diet
Exposure to certain chemical carcinogens in the foods of the first 20 years of life or over a prolonged period of time may increase the risk of gastric/stomach cancer.

* Bacteria
Researchers found that people with gastric/stomach cancer also contain the bacteria Helicobacter pylori in their stomach.

* Hydrochloric acid production
People with a low amount or no of hydrochloric acid produced by the stomach are at risk of developing gastric/stomach cancer

* Long-term inflammation of the stomach
People who have conditions associated with long-term stomach inflammation are at slightly increased risk of gastric/stomach cancer.

* Family history
The risk of gastric/stomach increases if one of the members of your direct family has it.

* Smoking is associated with gastric/stomach due to cigarette carcinogens.

* Obesity
Researchers found that overweight and obesity are associated with an increased risk of gastric/ stomach cancer. The strength of the association also increases with increasing BMI.


However, most people with some of the aforementioned risk factors have never developed gastric. stomach cancer.

Carotenoids are a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomatoes, pumpkins, carrots, corn, and daffodils.

In finding a natural pigment for the prevention and treatment of gastric/stomach cancer, researchers examined the effects of carotenoids, the fat-soluble pigments found abundantly in fruits and vegetables including total dietary carotenoids, dietary carotenoid subclasses (α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxanthin, and lycopene), and foods contributing to the dietary intake of each carotenoid on the risk of GC.

According to the results of the case-control study of 415 cases and 830 controls recruited from the National Cancer Center Hospital in Korea between March 2011 and December 2014,
* Intake of carotenoids exerted a significant inverse association with GC risk among women, with a relative odds ratio (OR) of 0.56.

* A higher intake of dietary lycopene was inversely associated with GC risk overall in the subjects with OR 0.60. In men, the OR was 0.60 compared to women with an OR of 0.54.

* In the subgroups of Helicobacter pylori (H. pylori)-positive subjects, dietary lycopene intake demonstrated a strong impact on GC risk was also observed in the subgroups of Helicobacter pylori (H. pylori)-positive subjects and ever smokers.


Compared to foods containing a high amount of carotenoids and lycopene, consumption of tomatoes and tomato ketchup was inversely associated with GC risk in the overall subjects, men, and women.


Based on the findings. researchers wrote, "Based on our findings, a higher intake of dietary lycopene and contributing foods of lycopene (tomatoes and tomato ketchup) may be inversely associated with the risk of GC".

Taken altogether, carotenoids containing a high amount of compound lycopene may be considered a remedy for the prevention and treatment of gastric cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary Carotenoids Intake and the Risk of Gastric Cancer: A Case-Control Study in Korea by Kim JH1, Lee J2, Choi IJ3, Kim YI4, Kwon O5, Kim H6, Kim J. (PubMed)
(2) Stomach Cancer/Gastric Cancer by Kyle J. Norton

Combination of Free Form of DOX@BET Induces #Cancer Cells Death, According to Studies

Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancers in the US.

The causes of cancer are unknown. age, excessive alcohol drinking, exposure to cancer causing-substances, diseases associated with chronic inflammation, unhealthy diet, hormone therapy, and use of immunosuppression are some of the prevalent factors involved in the onset of cancer.


However, most people with some of the aforementioned risk factors have never developed cancer.


Some researchers suggested that the rise of cancers in obese individuals may correlate to the promotion of the Western diet over the past few decades.

Dr.Timothy J Key, the lead scientist wrote, "Diet-related factors are thought to account for about 30% of cancers in developed countries. Obesity increases the risk of cancers in the esophagus, colorectum, breast, endometrium, and kidney. Alcohol causes cancers of the oral cavity, pharynx, larynx, esophagus, and liver, and causes a small increase in the risk of breast cancer".

And, "Adequate intakes of fruit and vegetables probably lower the risk for several types of cancer, especially cancers of the gastrointestinal tract".

Betanin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a natural ingredient that reduces the side effects of potent anticancer drugs e.g. doxorubicin (DOX) on the normal tissues, researchers examined the betanin (BET) effect in the co-administration with them.

In the study to overcome the restrictions of BET, researchers designed a new pH-responsive nanocarrier via decoration of gelatin nanoparticles (GNPs) by (methoxy poly (ethylene glycol)-poly ((2-dimethylamino) ethyl methacrylate-co-itaconic acid) (PGNPs) for the DOX and BET loading capacity of 20.5% and 16.25%, respectively).

Injection of DOX@BET loaded PGNPs decreased the significant cell viability amount of breast cancer cells (MCF-7) compared to the treatment of the free form of DOX or BET.

In other words, the newly designed combination kills induce a higher percentage of cell death compared to the use of DOX or BET individually.

Sadly, the study did not confirm the combination reduced the side effects caused by DOX during the experiment.

Dr. Javadi B in the examination of herbal plants for the treatment of breast cancer showed that beetroot (Beta vulgris) induced cancer death by cytotoxicity without affecting the nearby healthy cells.

He continued, "Additional pharmacological studies and clinical trials are needed to elucidate their molecular and cellular mechanisms of actions, frequency, and amount of consumption, possible adverse effects, and optimum preparation methods.".

Taken together, betanin used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A novel smart PEGylated gelatin nanoparticle for co-delivery of doxorubicin and betanin: A strategy for enhancing the therapeutic efficacy of chemotherapy by Amjadi S1, Hamishehkar H2, Ghorbani M. (PubMed)
(2) Diet Therapy for Cancer Prevention and Treatment Based on Traditional Persian Medicine by Javadi B. (PubMed)
(3) The effect of diet on risk of cancer by Dr. Timothy J Key, Naomi E Allen, Elizabeth A Spencer,
Ruth C Travis. (The Lancet)

#Phytochemical #Indicaxanthin Inhibits #ColorectalCancer by Inducing Apoptosis and Anti-Proliferation, According to Studies

Kyle J. Norton

The bowel forms the lower part of the digestive system consisting of the small bowel (or small intestine) and the large bowel(colon and rectum).
The large bowel plays an essential role in absorbing water, and restoring and removing waste.

Cancer is a class of medical condition caused alternation of cell DNA that starts on the surface of the inner lining of the tissue of a specific organ. Compared to a benign tumor, invasive tumor cells at the advanced stage can travel a distance away to infect other healthy tissue through blood and fluid circulation.

Colorectal Cancer is a medical condition caused by cell growth in the tissues of the colon or rectum.

According to the statistics provided by the American Cancer Society in 2019, approximately
101,420 new cases of colon cancer and 44,180 new cases of rectal cancer will be diagnosed in the US.

Furthermore, the overall, lifetime risk of colorectal cancer of developing is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

Colorectal cancer is a relatively very common and slowly growing and progressing cancer. It is the third most commonly diagnosed cancer in developed countries, including the U.S. and Canada.

Most patients with colorectal cancer at the early stage are asymptomatic. However, at the advanced stage patients might experience symptoms of changes in bowel habits, narrow stools, constipation, diarrhea, irritable bowel syndrome, intermittent, ulcerative colitis, Crohn's disease, diverticulosis, peptic ulcer disease, abdominal pain, accompanied by general symptoms shared by other types of cancer.

Conventionally, treatment of colorectal cancer totally depends on the stage of cancer, including localized(0), regional (1) and distance spread cancer (2 - nearby tissue, 3 - spread to the lymph node, 4, spread to organs and tissues)

The most common type of colorectal cancer is Adenocarcinomas which originate in the surface of the inner layer that lines the cavities and organs of the body.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, which a closely related of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
Indicaxanthin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains found abundantly in beets, chard, etc.

In finding a potent compound for the treatment of colorectal cancer, researchers examined the effect of the aqueous extract and of its betalain pigment indicaxanthin (Ind), on the proliferation of human colorectal cancer Caco-2 cells.

According to the tested assays, administration of whole extract and Ind exerted a strong activity to induce apoptosis and anti-proliferation at nutritionally relevant amounts, with IC50 400±25 mg fresh pulp equivalents/mL, and 115±15 μM (n=9), respectively at a dose-dependent manner.

More importantly, the inhibition of colorectal cancer cells by whole extract and Ind without causing toxicity for post-confluent differentiated cells.

In chemical analysis, Ind was found to account for ∼80% of the effect of the whole extract. Ind did cause oxidative stress in proliferating Caco-2 cells.

Furthermore, Ind was found to act as a de-methylation of the tumor suppressor p16(INK4a) gene promoter, in the activation of cell cycle arrest in the G2/M-phase in the tested cell line.

More precisely, Ind kills cancer cells by decreasing hyper-phosphorylated associated with cell cycle division and promoting hypo-phosphorylated associated with cell cycle arrest without alternating the cell division enzyme cyclin-dependent kinase 4 (CD4).


Taken together, indicaxanthin may be considered a remedy for the prevention and treatment of colorectal cancer, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-proliferative and pro-apoptotic activity of whole extract and isolated indicaxanthin from Opuntia ficus-indica associated with re-activation of the onco-suppressor p16(INK4a) gene in human colorectal carcinoma (Caco-2) cells by Naselli F1, Tesoriere L1, Caradonna F1, Bellavia D1, Attanzio A1, Gentile C1, Livrea MA. (PubMed)