#Alliin Detoxes the Liver Against the Risk of #LiverCancer, Researchers Say

Kyle J. Norton

The liver is the largest internal organ and plays a critical role in filtering blood coming from the intestine before passing to the heart and other parts of the body.

The liver also produces bile that aids the digestive function in digesting lipids and absorbing the nutrients from food and cholesterol that are essential to build a strong cell membrane, production of steroid hormones, and vitamin D.

However, overexpression of cholesterol in the blood has been found to induce plaque accumulated on the arterial wall, increasing the risk of cardiovascular disease.

Primary liver cancer is a medical condition caused by irregular cell growth in the liver tissue as a result of the alternation of cell DNA.

According to the statistics, in 2019, approximately, 42,030 adults (29,480 men and 12,550 women) in the United States will be diagnosed with primary liver cancer.

Believe it or not, since 1980, the incidence of liver cancer has tripled. Between 2006 and 2015, the number of people diagnosed with primary liver cancer increased by approximately 3% annually.

Most cases of primary liver cancer begin in the cell on the surface of the inner lining of the liver tissue, before penetrating into the deeper layers and spreading to other nearby tissues and organs.

Epidemiologically, primary liver cancer has been found metastasizing to the lung (median 44%), portal vein (35%), and portal lymph node(s) (27%). Furthermore, the most common causes of liver cancer death are liver failure (34%), bleeding (30%), and advanced cancer (24%).

Interestingly, the pattern of metastasis of primary liver cancer caused by the cirrhotic liver is somewhat different from that of the noncirrhotic.


Out of many risk factors associated with the onset of primary liver cancer, some researchers suggested accessive alcohol consumption may be the main culprit that causes the rise of liver cancer incidence in the Western world.


Dr. F. Turati, the lead scientist wrote, "Compared with non-drinking, the pooled RRs were 0.91 (95% confidence interval, CI, 0.81–1.02) for moderate drinking (<3 drinks per day) and 1.16 (95% CI, 1.01–1.34) for heavy drinking (≥3 drinks per day), with significant heterogeneity among studies".


And, "The dose–risk curve suggested a linear relationship with increasing alcohol intake in drinkers, with an estimated excess risk of 46% for 5g of ethanol per day and 66% for 10g per day. This systematic review suggests a moderate detrimental role of consumption of 3 or more alcoholic drinks per day on liver cancer and a lack of association with moderate drinking".

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With the aim to find a potential compound for the treatment of liver cancer, researchers examined the
protective effects of three garlic powders, obtained from bulbs grown in soils with different levels of sulfur fertilization, against DNA damage in the animal liver.


Believe it or not, increasing fertilization of soil that grows garlic has shown to increase the alliin content of the powders.

According to the tested assays, garlic powders administered to rats for 2 weeks (5% of the diet) demonstrated a 35-60% reduction in DNA damage induced by N-nitrosodimethylamine (NDMA) in rat liver.

Furthermore, by increasing the alliin content in the powders, tested garlic powders strongly exerted a proportional decrease in NDMA-induced DNA alteration.

In other words, by increasing alliin content, garlic powders protect the integrity and viability of the liver cells against DNA alternation in facilitating the onset of liver cancer.

Moreover, DNA damage induced by aflatoxin B1 in the liver was also decreased strongly by the three garlic powders regardless of the content of alliin.

The results suggested that alliin protects the liver cells against DNA alternation and works synergistically with other compounds in the garlic to inhibit the damage of liver cells.

Based on the findings, researchers said, "(There is evidence) that fertilization can have an impact on the protective capacity of garlic bulbs".

In order to reveal more information about alliin anti-liver cancer activity, researchers compared the chemopreventive efficacies of several garlic powders with various levels of alliin, a precursor of active sulfur compounds.

In hepatocarcinogenesis initiated by the administration of 10 i.p. injections of 0.025 mg/kg body weight aflatoxin B1 (AFB1), rats fed diets containing three garlic powders (5% of the diet) with various alliin contents for 3 weeks showed a decreased the appearance and size of hepatic GST-P foci, an early marker of liver cancer.

An increased alliin content showed a strong reduction appearance and size of hepatic GST-P foci compared to lower content in tested rats.

Additionally, increased alliin content of the garlic powder was also associated with a proportional decrease in the number and area of preneoplastic foci in the liver.

Garlic powder ingestion in the inhibition was also partly attributed to the stimulation of the increased levels of hepatic ethoxy resorufin demethylase, glutathione S-transferase and UDP glucuronosyltransferase, and AFB1 associated with liver detoxification with no effect on the levels of nifedipine oxidase involved in C-oxidative metabolism.

Based on the findings, Dr. Bergès R, the lead scientist said, "garlic partly exerts its anticarcinogenic effects through increasing enzymes involved in AFB1 detoxification".


Taken together, alliin may be considered a supplement for the prevention and treatment of liver cancer with no side effects, pending the confirmation of the larger sample size and multicenter human study.


Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca



Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) EGFR gene regulation in colorectal cancer cells by garlic phytocompounds with special emphasis on S-Allyl-L-Cysteine Sulfoxide by Roy N1, Nazeem PA2, Babu TD3, Abida PS2, Narayanankutty A3, Valsalan R2, Valsala PA2, Raghavamenon AC. (PubMed)
(2) Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content by Singh V1, Belloir C, Siess MH, Le Bon AM. (PubMed)
(3) Primary liver cancer: pattern of metastasis by Lee YT, Geer DA. (PubMed)
(4) Alcohol and liver cancer: a systematic review and meta-analysis of prospective studies by F. Turati C. Galeone M. Rota C. Pelucchi E. Negri V. Bagnardi G. Corrao. Boffetta C. La Vecchia. (Oxford Adcamic)

#Tomato's #Lycopene Inhibits Hepatic Markers Associated with a Reduced Risk of Liver Damage and Injury, According to Studies

Kyle J. Norton


A hepatic marker is a blood test that measures the function of the liver. In other words, according to the blood test results, your doctor may know the severity of the liver damage.

The liver is the largest internal organ in the body which plays a critical role in filtering out blood from the digestive system before passing it to other parts of the body.

Furthermore, the liver also produces bile which has a strong impact on the building of cell membranes, production of steroid hormones and vitamin D, and aiding the digestive system in the absorption of nutrients.

Liver transaminases aspartate transaminase (AST) and alanine transaminase (ALT) are some of the liver markers used by researchers to measure liver injury in a patient with some degree of intact liver function.

Aspartate transaminase (AST) is an enzyme found primarily in the liver and kidney. High levels of ALT is associated with liver damage. ALT screening is used often in patients with
liver disease.

Alanine aminotransferase (ALT) is a liver enzyme. increased levels of ALT have been found in patients with liver damage.

Other liver enzymes such as Alkaline phosphatase (ALP) and Gamma-glutamyl transpeptidase (GGT) also have a similar effect as seen in ALT and AST.

More precisely, elevated liver enzymes is an indication of liver inflammation or cell damage.
Dr. Edoardo G. Giannin, the lead scientist in the explanation of liver enzyme alternation, wrote, "Abnormal liver enzyme levels may signal liver damage or alteration in bile flow. Liver enzyme alteration may be either the accompanying biochemical picture in a patient with symptoms or signs suggestive of liver disease or an isolated, unexpected finding in a patient who has undergone a wide range of laboratory tests for a nonhepatic disease or for minor, vague complaints".


And, "The pattern of enzyme abnormality, interpreted in the context of the patient's characteristics, can aid in directing the subsequent diagnostic work-up. Awareness of the prevalence of the determining liver disease in specific populations and of possible hepatic involvement during systemic illnesses or drug therapies may help the clinician identify the cause of alterations efficiently".

The results strongly suggested that testing hepatic markers of patients with liver disease may be helpful in identifying the causes.

Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to discover healthy foods that process liver-protective effects, researchers examined the effect of dry tomato peel (DTP) on hepatic markers in a high-saturated-fat (HSF) diet animal model for 12 weeks.

The study included 40 8 weeks, weighing 22.2±1.0 g) BALB/c male mice (n=40) divided into four treatment groups (10 mice/group): (a) high-fat control diet (HF Ctrl), which contains sunflower oil as a sole source of fat; (b) HSF/high-cholesterol (HC) diet; (c) HSF/HC diet supplemented with 9% DTP and (d) HSF/HC diet supplemented with 17% DTP.


According to the tested assays, without supplements with DTP, HSF/HC diet-treated mice showed significantly increased body weight gain, adipose tissue weight, insulin resistance, and lipid peroxidation in the liver as well as the onset of liver steatosis and inflammation.


Upon the injection of DTP, HSF/HC diet mice demonstrated a significant increase in plasma lycopene concentration and reduced markers associated with metabolic syndrome developing.

In other words, DTP inhibits the liver damage and injury marker through its anti-inflammatory and antioxidant activity and lipid metabolism

Taken together, tomatoes processed with a high amount of lycopene may be considered a dietary supplement for liver protection, pending a large sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of dry tomato peel supplementation on glucose tolerance, insulin resistance, and hepatic markers in mice fed high-saturated-fat/high-cholesterol diets by Zidani S1, Benakmoum A2, Ammouche A3, Benali Y4, Bouhadef A4, Abbeddou S. (PubMed)
(2) Feeding tomato and broccoli powders enriched with bioactive improve bioactivity markers in rats by Liu AG1, Volker SE, Jeffery EH, Erdman JW Jr. (PubMed)
(3) Liver enzyme alteration: a guide for clinicians by Edoardo G. Giannini, Roberto Testa, and Vincenzo Savarino. (PMC)

#Herbal #Arctostaphylos uva-ursi, Detoxes Body Toxins by Diuresis, Researchers Find

Kyle J. Norton

Scientists may have found a functional herbal medicine that has a significant effect in promoting the secretion of toxin by increasing the urinary flow, some studies suggested.

The diuretic effect is the activity of substances that promote urinary secretion.

Many diuretics medicine can interfere with the functioning kidney in the regulation of the levels of water in the body, leading to worsening kidney function and abnormal electrolyte levels.

Certain medications that treat conditions of high blood pressure, glaucoma, and edema can damage the kidney function by overworking the kidney in water release.


Dr. Yusra Habib Khan, the lead author in the study "Chronic Kidney Disease, Fluid Overload and Diuretics: A Complicated Triangle" said, "The use of diuretics was associated with adverse renal outcomes indicated by a decline in eGFR (Glomerular filtration rate (GFR) is a measure of the function of the kidneys) and increased risk of (renal replacement therapy) RRT initiation in our cohort of NDD-CKD patients".

Therefore, the intake of medicine that has a negative effect on kidney function and diuretics medicine should be taken with extreme care. If you are currently taking some of the above medicines, please make sure that you know the adverse effects.

Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.

The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infections, kidney stones, pelvic pain, etc.

Besides the major constituents of phenolic glycoside arbutin, tannins, and flavonoids, herbal medicine also contains free hydroquinocoumaric acidaric acid, caffeic acid, salicylic acid, flavonoid quercetin, and triterpenes ursolic acid.

Because of increased awareness of conventional medication's side effects, there is increasing interest in the health and wellness benefits of herbs and botanicals. According to the Laboratoire de Pharmacognosie, in an animal study, Arctostaphylos uva-ursi and hydroalcoholic extracts increased urine flow. Urinary sodium excretion in rats.

The use of herbal diuresis should be taken with care and under professional prescription as the application may have a strong effect on the increase of urine flow rates to induce renal clearance of the toxicant.

In the article written by Michael E. Peterson DVM, MS, in Small Animal Toxicology (Third Edition), 2013, the author wrote, that intoxications that are most likely to respond to force diuresis are those with a high level of renal excretion of the primary toxicant (e.g., bromide, lithium, amphetamine, phenobarbital, and salicylate).

Protein-bound toxins are not cleared efficiently by diuresis.

However, the patient must not be anuric or significantly oliguric

The primary problems associated with force diuresis include potential fluid overload and electrolyte abnormalities.

Michael E. Peterson DVM, MS, continued, "The practitioner should monitor for hyponatremia, hypokalemia, water intoxication, pulmonary edema, and cerebral edema. Additionally, some toxins such as tricyclic antidepressants and many sedative-hypnotics increase the patient’s susceptibility to interstitial pulmonary edema. Forced diuresis is contraindicated in these intoxications"

These results suggested that although herbal Arctostaphylos uva-ursi may be potent in detoxing the body toxin through increasing urinary secretion. However, caution should be taken to prevent damage to kidney and kidney function.

Please make sure you only take the Arctostaphylos uva-ursi extract with the permission of the specialists in the related field.

However, additional data collection large example size and multi-center studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of herbal Arctostaphylos uva-ursi diuretic possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



References
(1) Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosellaL., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats BY Beaux D, Fleurentin J, Mortier F.(PubMed)
(2) Toxicologic Decontamination by Michael E. Peterson DVM, MS, in Small Animal Toxicology (Third Edition), 2013. (Science Direct)

#Indicaxanthin Shows a Significant Activity in Neuromodulation and Inflammatory Regulation Associated with Cellular Damage, Researchers Say

Kyle J. Norton


Chemotherapy is a type of therapy that uses drugs to destroy cancer cells by keeping them from proliferation and migration.

Under normal circumstances, cell growth is a natural process. Every day millions of cells grow to replace millions of dead cells and to keep our body in balance and healthy.

Sometimes, acceleration of cell growth is necessary to prevent further damage to the body organ, such as cuts, injuries, etc., but after fulfilling their purposes, the growth of cells is back to a normal growth rate again.

Cancer cells are fast-growing cells that ignore the cell cycle inhibitors that stop the cell from growing after a certain cell cycle division compared to normal cells.

According to the statistics provided by the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes. In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer, and 1,790 died of the disease.

Conventionally, chemo drugs used for chemotherapy are powerful for the treatment of cancers, however, they also can cause damage to nearby healthy cells, leading to serious adverse effects.

Cancer is a class of chronic diseases caused by cell growth and multiplies disorderedly and uncontrollably in the body.

Depending on the types and grades of cancer, some cancers can be progressively worse and damage other healthy tissues. Sometimes cancers can spread to other tissues and organs in the body via lymph or blood.

The exact causes of cancer are unknown. Carcinoma accounting for over 90% of cancer diagnosed, is a malignant tumor found in anywhere of the epithelial tissues lining the cavities, surfaces of structures, and glands, including the breast, prostate, lung, and colon.

Treatment of cancer conventionally totally depends on the type, grade, and stage of cancer. Surgery, radiation, and chemodrugs are used for the treatment in most cases of invasive cancer.


Indicaxanthin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains found abundantly in beets, chard, etc.

On finding a potential compound that processes chemo-activity, researchers examined the effect of Indicaxanthin as a natural chemopreventive agent.

According to the tested analysis, the bioactive compound showed significant activity in neuromodulation and inflammatory regulation that prevents cellular damage.

Indicaxanthin protects the integrity of the neuron against the alternation of cell DNA.

Moreover, the phytochemical also inhibited the overexpression of cancer tissues. Indicaxanthin inhibited the parameters associated with the cancer expression in the cells of breast, thyroid, and prostate cancer, including anti-proliferative activity.


More importantly, indicaxanthin also inhibited the proteins involved in the initiation and progression of the cancer cells.


Taken altogether, indicaxanthin may be considered a chemo-active remedy, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Reverse screening on indicaxanthin from Opuntia ficus-indica as a natural chemoactive and chemopreventive agent by Tutone M1, Virzì A2, Almerico AM2. (PubMed)

#Onion #Extract Exerts A Strong Antioxidant and Doxorubicin Anti-Cancer Activity, Scientists Say

Kyle J. Norton

Cardiotoxicity is a medical condition that causes damage to the heart muscle, leading to reduced heart muscle function to pump blood and heart failure.
Long-term intake of certain medications and people who are under treatment of chemotherapy have been found in most cases of cardiotoxicity.

However, people who are infected by the human immunodeficiency virus (HIV) genetic preposition, a malignant disease associated with the amyloid deposited on the heart or other organs, high blood pressure, untreated hyperthyroidism, and vitamin b2 deficiency are some of the most prevalent factors found in patients with cardiotoxicity.

The most common symptoms of cardiotoxicity are associated with not enough blood circulation in the body such as tiredness and fatigue, a long-term (chronic) cough, shortness of breath, floating due to the enlarged heart muscle, abnormal heart or lung sounds and swelling in your hands, feet, or unusual weight gain.

Conventionally, treatment of cardiotoxicity is totally depends on the types of the disease including
Beta-blockers, and ACE inhibitors induce (widen) the arterial dilation and improvement of the blood flow and diuretics.

Some researchers in examining the risk of cardiotoxicity in patients with chemotherapy wrote, "Age and preexisting left ventricular dysfunction have been identified most consistently as being associated with the development of clinical heart failure or a worsening of left ventricular function with chemotherapy".

And, ""Other cardiovascular conditions, including hypertension, diabetes, and coronary artery disease, are also associated with the risk of cardiotoxicity".

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

In finding a potent ingredient that processes cardio-protective activity researchers examined the effects of extracts from edible wild onion species, Allium flavum, and Allium carinatum, which reduce side effects of cytostatic doxorubicin (Dox).

In human hepatoma (HepG2) and lung carcinoma (A549) cells, the methanol extracts exhibited high levels of antioxidant activity and worked synergistically to increase Dox anticancer activity, without affecting the health of normal cells.

Furthermore, antioxidative enzyme levels such as catalase and superoxide dismutases in the cancer cells were also suppressed by the chemicals, compared to normal cells upon applied treatments.

In the toxicity assays on the zebrafish model, the chemical extracts isolated from edible wild onion species process lower toxicity compared to Dox, with no teratogenic effects at applied doses.


Most importantly, the extracts not only successfully protect the Dox-treated embryos of life-threatening cardiomyopathy but also reduce developmental toxicity and neutropenia. in the zebrafish model.

Additionally, the extracts also processed a higher anti-angiogenic activity compared to those of antiangiogenic drugs such as sunitinib or auranofin.

Taken together, onion extracts may be considered a remedy for the prevention and treatment of cardio-toxicity, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Wild edible onions - Allium flavum and Allium carinatum - successfully prevent adverse effects of chemotherapeutic drug doxorubicin by Aleksandar P1, Dragana MĆ2, Nebojša J3, Biljana N3, Nataša S4, Branka V5, Jelena KV. (PubMed)
(2) Risk factors for chemotherapy-related cardiac toxicity by Polonsky TS1, DeCara JM. (PubMed)

#Healthyfood Cucumber' #Cucurbitacin B Exerts a Strong Anti-#CardiacHypertrophy Through Stimulating Cardiac Muscle Cells

Kyle J. Norton

Cardiac hypertrophy (CH) is a medical condition characterized by the abnormal enlargement or thickening of the heart muscle, affecting the heart's function in pumping blood.
Cardiac hypertrophy-induced reduced blood flow to the body may cause symptoms of shortness of breath, and chest pain, particularly during exercise.

In some serious cases, CH can disrupt the heart's electrical system, leading to life-threatening abnormal heart rhythms (arrhythmias).

The most common types of CH include
*Ventricular hypertrophy due to intense sports activities, particularly in people with intensive exercise

* Ventricular hypertrophy due to hypertension-induced ventricular pressure overload.
and
* Ventricular hypertrophy due to tricuspid regurgitation-induced ventricular volume overload.

Although there are various causes associated with the onset of CH, the most common cause of CH is associated with plaque accumulated on the arterial wall resulting in a blockage that causes damage to the heart muscle.

Dr. Joa˜o Carlos Hueb, the lead scientist in the article "Association Between Atherosclerotic Aortic Plaques and Left Ventricular Hypertrophy in Patients With Cerebrovascular Events" wrote, "Almost half of the patients (43.1%) presented atherosclerotic lesions in the aorta. LVH was present in 90.0% of patients with plaque and in only 30.3% of patients without plaque. Using high blood pressure as a covariate, the risk of patients with LVH presenting atherosclerotic plaque in the aorta was 18.23-fold greater than the risk for patients without LVH (95% CI, 5.68 to 58.54; P0.0001)"

And, "Adding age into the model, the risk increased to 26.36 (95% CI, 7.14 to 97.30; P0.0001). Conclusions—LVH detected by conventional echocardiogram is associated with a high risk of atherosclerotic plaque in the aorta and would be used as a criterion for an indication of transesophageal".


The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.

In the urgency to find a natural treatment that processes anti-cardiac hypertrophy associated with the prevalence of heart failure, researchers evaluated the anti-hypertrophy and anti-fibrosis potential of a natural plant triterpenoid, Cucurbitacin B in vivo.

The study included mice induced cardiac hypertrophy by aortic banding (AB) received cucurbitacin B treatment (Gavage, 0.2 mg/kg body weight/2 day) after 1 week of surgery.

Observation after 4 weeks of AB, cucurbitacin B (CuB) demonstrated a strong anti-hypertrophy and -fibrosis ability by decreasing heart weight, myocardial cell cross-sectional area, and interstitial fibrosis.

Furthermore, CuB also protects the heart by ameliorating systolic and diastolic abnormalities, normalizing the gene expression of hypertrophic and fibrotic markers induced by aortic banding (AB).

Moreover, cucurbitacin B also showed a significant hypertrophy inhibitory effect in phenylephrine that stimulates cardiac muscle cells.


The efficacy of CuB in the inhibition of abnormal enlargement, or thickening, of the heart muscle, was attributed to the increasing level of autophagy involved in the orderly degradation and recycling of cellular components by blocking signaling pathways associated with inhibited autophagy.

Taken together, cucumber processed a major compound cucurbitacin B (CuB) may be used for the treatment of cardiac hypertrophy, pending the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy by Xiao Y1,2,3, Yang Z1,2,3, Wu QQ1,2,3, Jiang XH1,2,3, Yuan Y1,2,3, Chang W1,2,3, Bian ZY1,2,3, Zhu JX1,2,3, Tang QZ. (PubMed)
(2) Association Between Atherosclerotic Aortic Plaques and Left Ventricular Hypertrophy in Patients With Cerebrovascular Events" by Joa˜o Carlos Hueb, MD, PhD; Silme´ia G. Zanati, MD; Katashi Okoshi, MD, PhD; Ce´sar N. Raffin, MD, PhD; Liciana Vaz de Arruda Silveira, PhD; Beatriz B. Matsubara, MD, PhD. (AHA journals)

#Healthyfood #Tomato Activates Anti-Inflammatory Genes Associated with a Reduced Risk of #InflammatoryBowelDiseases (IBD), Researchers Show.

Kyle J. Norton

Inflammation is a natural defense of the immune system that protects the body against the invasion of foreign pathogens.
Acute inflammation occurs quickly or within hours and lasts a few days or weeks.

In the acute phase of inflammation, damaged tissues are healed itself after all pathogens are killed off.


However, if the immune system can not completely destroy all invaders in the acute phase of infection within 3 to 8 weeks, it will compromise, leading to chronic low-grade inflammation, a major cause of cardiovascular disease, arthritis, and diabetes.

In most cases, depending on the type of injury, overproduction of pro-inflammatory cytokines in the acute phase of infection can cause damage to the nearby healthy tissues, leading to the formation of scars.

Anti-inflammatory is a process that inhibits the inflammatory symptoms without affecting the pro-inflammatory function of killing microorganisms.

Conventionally, the most common use of anti-inflammatory medicine for the treatment of symptoms induced by pro-inflammatory cytokines is Nonsteroidal anti-inflammatory drugs (NSAIDs) focusing on pain relief, including aspirin, ibuprofen (Advil, Motrin, Midol) and naproxen (Aleve, Naprosyn).

If you are planning to take them in the long term, please make sure that you know all the side effects.

Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In finding healthy food for the treatment of diseases associated with inflammation, researchers examined the tomato effects on the inflammation that causes intestinal dysbiosis associated with the onset of inflammatory bowel diseases (IBD).

The study included Winnie mice, a model of spontaneous ulcerative colitis received chows enriched with 1% Bronze tomato.

According to the tested assays, at week 2, the Bronze-enriched chow administered showed no macroscopic effect on the IBD symptoms. However, at the molecular level, the Bronze-enriched chow demonstrated significant activity in the activation of anti-inflammatory genes.


According to the intracellular staining of T cells, proteins associated with the production of pro-inflammatory cytokines ( IL17A, IFNγ) were significantly inhibited by the injection of Bronez tomato.

Based on the analysis of the microbial composition, researchers also found that two weeks of Bronze enriched diet was sufficient to alter positively the microbial composition of the tested subjects.


In other words, polyphenols found in the Bronze tomato have created unfavorable conditions for bad bacterial species in the gastrointestinal tract to stimulate the progression of IBD.

Dr. Liso M, the lead scientist wrote, after taking other factors into account, "dietary regimes enriched in polyphenols may efficiently support IBD remission affecting the intestinal dysbiosis:.


Taken together, tomato may be considered a dietary supplement for the prevention and treatment of IBD, pending a large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions by Liso M1, De Santis S2, Scarano A3, Verna G4, Dicarlo M5, Galleggiante V6, Campiglia P7, Mastronardi M8, Lippolis A9, Vacca M10, Sobolewski A11, Serino G12, Butelli E13, De Angelis M14, Martin C15, Santino A16, Chieppa M. (PubMed)
(2) Impact of Dietary Tomato Juice on Changes in Pulmonary Oxidative Stress, Inflammation and Structure Induced by Neonatal Hyperoxia in Mice (Mus musculus) by Bouch S1, Harding R1, O'Reilly M1, Wood LG2, Sozo F. (PubMed)