Kyle J. Norton
Bioactive dithiolthiones found in cruciferous vegetables may be the next-generation ingredient for the prevention and treatment of cardiovascular disease, some scientists suggested.
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
Cardiovascular disease is a class of conditions associated with the heart and blood vessels. In other words, CVD can be a result of anything that impedes the function of the heart and blood vessels.
According to the CVD statistics, heart disease kills more than 2,000 Americans every day. Approximately 60 million Americans have heart disease.
There are many causes of cardiovascular disease. Most CVD is caused by high blood pressure which contributes to the hardening of the arteries.
Plaques building up inside the arteries as a result of high blood cholesterol and other substances such as calcium over time can harden and narrow the arteries, leading to a blood clot, a major cause of CVD.
Other risk factors associated with the onset of cardiovascular disease include unhealthy diet, lack of exercise, being overweight, and smoking.
Dr. Haskell W, Stanford University, School of Medicine in the examine the lifestyle change in the risk of CVD indicated that there is a strong relationship between the way a person or population lives and their risk for developing or dying from cardiovascular disease (CVD).
How to prevent the onset of CVD
He wrote, "Not smoking, being physically active, eating a heart-healthy diet, staying reasonably lean, and avoiding major stress and depression are the major components of an effective CVD prevention program"/
For people with higher-risk CVD, the doctor continued, "medications frequently need to be added to a healthy lifestyle to minimize their risk of a heart attack or stroke, particularly in persons with conditions such as hypertension, hypercholesterolemia, or hyperglycemia".
With an aim to find a natural ingredient or whole food with a cardioprotective effect, researchers examined whether sulforaphane protects the heart against I/R injury.
Sprague-Dawley rats selected for the study were given sulforaphane (500microg/kg/day) or vehicle intraperitoneally for 3 days and global ischemia was performed using isolated perfused Langendorff hearts.
Treatment with sulforaphane inhibited an increase in the post-ischemic left ventricular end-diastolic pressure (LVEDP) and improved the post-ischemic left ventricular developed pressure (LVDP), +/-dP/dt, and coronary flow as compared with the untreated control hearts.
Sulforaphane markedly decreased the infarcted size and attenuated the increased lactate dehydrogenase level in the effluent during reperfusion, similar to that of 5-hydroxydecanoic acid (5-HD).
Application of sulforaphane also attenuated the post-ischemia increased the concentration of atrial natriuretic peptide in coronary effluent and decreased levels of free radicals produced during and after injury.
Particularly, sulforaphane also protects the heart cell against damage and apoptosis by promoting heart cell cycle division.
The finding clearly indicated the cardioprotective effect of the sulforaphane against acute I/R injury.
In order to understand the therapeutic effect of sulforaphane protecting the myocardium from ischaemic reperfusion injury, researchers compared the cardio effects among cooked and fresh broccoli.
The study included two groups of rats fed with fresh (steamed) broccoli or cooked broccoli for 30 d, while a third group was given a vehicle only for the same period of time.
At the end of the study, by examining the 30 min ischemia followed by 2 h of reperfusion, researchers surprisingly found that both cooked and steamed broccoli display significantly improved post-ischemic ventricular function and reduced myocardial infarction and cardiomyocyte apoptosis compared to control, but steamed broccoli showed superior cardioprotective abilities compared with the cooked broccoli.
These results were attributed to the broccoli effect in enhancing the levels of proteins associated with cell survival, increasing the levels of antioxidants, and decreasing the levels of proteins associated with cell damage and apoptosis.
More importantly, the expressions of redox proteins (the thioredoxin (Trx)) associated with the reduction of oxidative stress were enhanced only in the steamed broccoli group.
Dr. Mukherjee S, the lead scientist said, "The present study documented superior cardioprotective properties of the steamed broccoli overcooked broccoli because of the ability of fresh broccoli to perform redox signaling of Trx"
Taken together, Isothiocyanates or sulforaphane may have a potential effect on the prevention and treatment of cardiovascular disease.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels. by Piao CS1, Gao S, Lee GH, Kim do S, Park BH, Chae SW, Chae HJ, Kim SH. (PubMed)
(2) Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury. by Mukherjee S1, Lekli I, Ray D, Gangopadhyay H, Raychaudhuri U, Das DK. (PubMed)
(3) Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging by Chapple SJ1, Siow RC, Mann GE .(PubMed)
(4) Cardiovascular disease prevention and lifestyle interventions: effectiveness and efficacy by Haskell WL. (PubMed)
Tuesday, 10 October 2023
#Phytochemical #Isobetanin and Betalains in the Promotion of #Myeloperoxidase Against Microbial Infection, Researchers Say
Kyle J. Norton
Myeloperoxidase (MPO) is a peroxidase enzyme found most abundantly in white blood cells neutrophil granulocytes.
Myeloperoxidase (MPO) plays a critical role that protecting our body against the invasion of microorganisms.
At cellular levels, myeloperoxidase (MPO) is demonstrated to be a local mediator of tissue damage by stimulating the production of proinflammatory cytokines with an aim to protect the cell against the invasion of pathogens that may enter the body to induce the acute phase of infection.
In other words, MPO deficiency that induces the exaggeration of the inflammatory response and affects neutrophil functions including cytokine production has been found to reduce the immune function in the acute phase of infection that leads to chronic low-grade inflammatory disease.
MPO deficiency has been found in patients with diabetes mellitus, pregnancy, iron deficiency, renal transplantation, thrombotic diseases, lead poisoning, obstructive jaundice, disseminated cancers, hematologic disorders, and neoplasms.
However, genetic predisposition may be the primary condition that causes the onset of PMO deficiency.
Dr. Roma Pahwa wrote, "Primary MPO deficiency is inherited as an autosomal recessive disorder and is generally present with varying degrees of severity and clinical features. A number of point germline mutations resulting in MPO deficiency have been detected in primary form. Some of these mutations are associated with the defective posttranslational processing of the MPO precursor protein and others with pre-translational defects caused by mutations in the regulatory portion of the MPO gene".
And, " Most of the mutations associated with the hereditary form are R569W (the commonest), Y173C, M251T, G501S, and R499C and a deletion of 14 bases (D14) within exon 9. It is noteworthy that eosinophils are never involved in MPO deficiency since eosinophil peroxidase is encoded by another gene than MPO".
Isobetanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard,...
With an aim to find a potent compound for the prevention and treatment of bacterial infection, researchers examined the effects of phytochemical indicaxanthin on the enzyme myeloperoxidase.
The kinetic study conducted by the University of Palermo was to examine the interaction between the betalains, betanin, and indicaxanthin as redox intermediates of compound I and compound II of MPO.
Based on the tested differentiation, both compound I and compound II exhibited significant antioxidant activity was found to be associated with the concentration of betanin and indicaxanthin.
The presence of betalains and indicaxanthin exhibited the function of MPO in scavenging hypochlorous acid at pH 7.0 and 25 degrees C.
At neutral pH and depending on their concentration, both betalains and indicaxanthin.can exhibit a stimulating and inhibitory effect on the chlorination activity of MPO.
However, at pH 5.0 both betalains and can only exhibit a stimulating and inhibitory effect on the chlorination activity of MPO in the micromolar concentrations.
Taken altogether, indicaxanthin may be considered a remedy for the promotion of the antibacterial activity of myeloperoxidase, pending the confirmation of the larger sample size and multicenter human study.
Intake of Isobetanin and betalains in the form of supplements should be taken with extreme care to prevent liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) "Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid" by Allegra M, Furtmüller PG, Jantschko W, Zederbauer M, Tesoriere L, Livrea MA, Obinger C.(PubMed)
(2) Myeloperoxidase Deficiency by Roma Pahwa; Ishwarlal Jialal. (NCBI)
(3) Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function by Aratani Y. (PubMed)
Myeloperoxidase (MPO) is a peroxidase enzyme found most abundantly in white blood cells neutrophil granulocytes.
Myeloperoxidase (MPO) plays a critical role that protecting our body against the invasion of microorganisms.
At cellular levels, myeloperoxidase (MPO) is demonstrated to be a local mediator of tissue damage by stimulating the production of proinflammatory cytokines with an aim to protect the cell against the invasion of pathogens that may enter the body to induce the acute phase of infection.
In other words, MPO deficiency that induces the exaggeration of the inflammatory response and affects neutrophil functions including cytokine production has been found to reduce the immune function in the acute phase of infection that leads to chronic low-grade inflammatory disease.
MPO deficiency has been found in patients with diabetes mellitus, pregnancy, iron deficiency, renal transplantation, thrombotic diseases, lead poisoning, obstructive jaundice, disseminated cancers, hematologic disorders, and neoplasms.
However, genetic predisposition may be the primary condition that causes the onset of PMO deficiency.
Dr. Roma Pahwa wrote, "Primary MPO deficiency is inherited as an autosomal recessive disorder and is generally present with varying degrees of severity and clinical features. A number of point germline mutations resulting in MPO deficiency have been detected in primary form. Some of these mutations are associated with the defective posttranslational processing of the MPO precursor protein and others with pre-translational defects caused by mutations in the regulatory portion of the MPO gene".
And, " Most of the mutations associated with the hereditary form are R569W (the commonest), Y173C, M251T, G501S, and R499C and a deletion of 14 bases (D14) within exon 9. It is noteworthy that eosinophils are never involved in MPO deficiency since eosinophil peroxidase is encoded by another gene than MPO".
Isobetanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard,...
With an aim to find a potent compound for the prevention and treatment of bacterial infection, researchers examined the effects of phytochemical indicaxanthin on the enzyme myeloperoxidase.
The kinetic study conducted by the University of Palermo was to examine the interaction between the betalains, betanin, and indicaxanthin as redox intermediates of compound I and compound II of MPO.
Based on the tested differentiation, both compound I and compound II exhibited significant antioxidant activity was found to be associated with the concentration of betanin and indicaxanthin.
The presence of betalains and indicaxanthin exhibited the function of MPO in scavenging hypochlorous acid at pH 7.0 and 25 degrees C.
At neutral pH and depending on their concentration, both betalains and indicaxanthin.can exhibit a stimulating and inhibitory effect on the chlorination activity of MPO.
However, at pH 5.0 both betalains and can only exhibit a stimulating and inhibitory effect on the chlorination activity of MPO in the micromolar concentrations.
Taken altogether, indicaxanthin may be considered a remedy for the promotion of the antibacterial activity of myeloperoxidase, pending the confirmation of the larger sample size and multicenter human study.
Intake of Isobetanin and betalains in the form of supplements should be taken with extreme care to prevent liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) "Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid" by Allegra M, Furtmüller PG, Jantschko W, Zederbauer M, Tesoriere L, Livrea MA, Obinger C.(PubMed)
(2) Myeloperoxidase Deficiency by Roma Pahwa; Ishwarlal Jialal. (NCBI)
(3) Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function by Aratani Y. (PubMed)
#Sulforaphane Found in #BroccoliSprouts Inhibits Proteins Associated with the Onset of Neuro-degenerative Disease, According to Studies
Kyle J. Norton
Age-related neurological disorders or neurodegenerative diseases are the conditions associated with the progressive death of neurons due to aging, leading to problems with movement (called ataxias), or mental functioning including Alzheimer's disease (AD) and dementia.
Dementia is a general term for neurodegenerative disease that causes a decline in memory and thinking skills that are severe enough to reduce a person's ability to perform everyday activities and quality of life.
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age.
The most common type of dementia is Alzheimer's disease, the condition that destroys brain cells, causing problems with memory, thinking, and behavior severe enough to affect language communication, memory, lifelong hobbies, or social life. Alzheimer's gets worse over time, and it is fatal.
Over 1 million people in the US alone are currently afflicted by Alzheimer's disease because of the degeneration of the hippocampus and cerebral cortex(3) of the brain where memory, language, and cognition are located.
Parkinson's disease (PD) is a disabling, progressive condition that causes cognitive deficit due to the interruption of frontal-subcortical loops that facilitate cognition and parallel the motor loop, and the loss of substantia nigra pars compacta (SNc) dopamine (DA) neurons.
Besides aging, geographical, hereditary viral, and toxicological exposure may also correlate to the development of diseases in the elderly.
Dr. Hung CW in the examination of the neurodegenerative disease in the aging population wrote, "Ageing, which all creatures must encounter, is a challenge to every living organism. In the human body, it is estimated that cell division and metabolism occur exuberantly until about 25 years of age. Beyond this age, subsidiary products of metabolism and cell damage accumulate, and the phenotypes of aging appear, causing disease formation".
And, "Among these age-related diseases, neurodegenerative diseases have drawn a lot of attention due to their irreversibility, lack of effective treatment, and accompanied social and economic burdens".
With an aim to find a natural food for the prevention and treatment of neurodegenerative disease, researchers examined the effect of sulforaphane, an active compound produced after conversion of glucoraphanin by the myrosinase enzyme in broccoli (Brassica oleracea var) sprouts inflammatory conditions in aged models involving microglial activation.
According to the results of pretreatment of pulsed electric fields that trigger the biological role of normal broccoli against lipopolysaccharide-activated microglia, sulforaphane-enriched broccoli sprouts showed an excellent potency against neuroinflammation conditions, particularly in both 6 and 24 h of microglial activation.
Sulforaphane in broccoli sprouts also inhibited an inflammatory cascade by decreasing the function of proteins associated with the production of pro-inflammatory cytokines.
Furthermore, proteins associated with the production of antioxidant enzymes and inhibition of oxidative stress (Nrf2 and HO-1) were also increased by SFN followed by the lowered neuronal apoptosis induced by activated microglia.
Based on the results, researchers wrote, " sulforaphane-enriched broccoli sprouts improved the scopolamine-induced memory impairment in mice through Nrf2 activation, inhibiting neuronal apoptosis, particularly through inhibition of caspase-3 activation which could lead to the neuroprotection against neurodegenerative disorders".
In other words, SFN protects the integrity of the neurons against neuron damage through its anti-neuroinflammatory and neuroprotective activities.
Taken altogether, broccoli sprouts processed abundantly SFN may be considered supplements for the prevention of neurodegenerative disease, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sulforaphane-Enriched Broccoli Sprouts Pretreated by Pulsed Electric Fields Reduces Neuroinflammation and Ameliorates Scopolamine-Induced Amnesia in Mouse Brain through Its Antioxidant Ability via Nrf2-HO-1 Activation by Subedi L1, Cho K1, Park YU2, Choi HJ2, Kim SY. (PubMed)
(2) Aging and neurodegenerative diseases by Hung CW1, Chen YC, Hsieh WL, Chiou SH, Kao CL. (PubMed)
Age-related neurological disorders or neurodegenerative diseases are the conditions associated with the progressive death of neurons due to aging, leading to problems with movement (called ataxias), or mental functioning including Alzheimer's disease (AD) and dementia.
Dementia is a general term for neurodegenerative disease that causes a decline in memory and thinking skills that are severe enough to reduce a person's ability to perform everyday activities and quality of life.
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age.
The most common type of dementia is Alzheimer's disease, the condition that destroys brain cells, causing problems with memory, thinking, and behavior severe enough to affect language communication, memory, lifelong hobbies, or social life. Alzheimer's gets worse over time, and it is fatal.
Over 1 million people in the US alone are currently afflicted by Alzheimer's disease because of the degeneration of the hippocampus and cerebral cortex(3) of the brain where memory, language, and cognition are located.
Parkinson's disease (PD) is a disabling, progressive condition that causes cognitive deficit due to the interruption of frontal-subcortical loops that facilitate cognition and parallel the motor loop, and the loss of substantia nigra pars compacta (SNc) dopamine (DA) neurons.
Besides aging, geographical, hereditary viral, and toxicological exposure may also correlate to the development of diseases in the elderly.
Dr. Hung CW in the examination of the neurodegenerative disease in the aging population wrote, "Ageing, which all creatures must encounter, is a challenge to every living organism. In the human body, it is estimated that cell division and metabolism occur exuberantly until about 25 years of age. Beyond this age, subsidiary products of metabolism and cell damage accumulate, and the phenotypes of aging appear, causing disease formation".
And, "Among these age-related diseases, neurodegenerative diseases have drawn a lot of attention due to their irreversibility, lack of effective treatment, and accompanied social and economic burdens".
With an aim to find a natural food for the prevention and treatment of neurodegenerative disease, researchers examined the effect of sulforaphane, an active compound produced after conversion of glucoraphanin by the myrosinase enzyme in broccoli (Brassica oleracea var) sprouts inflammatory conditions in aged models involving microglial activation.
According to the results of pretreatment of pulsed electric fields that trigger the biological role of normal broccoli against lipopolysaccharide-activated microglia, sulforaphane-enriched broccoli sprouts showed an excellent potency against neuroinflammation conditions, particularly in both 6 and 24 h of microglial activation.
Sulforaphane in broccoli sprouts also inhibited an inflammatory cascade by decreasing the function of proteins associated with the production of pro-inflammatory cytokines.
Furthermore, proteins associated with the production of antioxidant enzymes and inhibition of oxidative stress (Nrf2 and HO-1) were also increased by SFN followed by the lowered neuronal apoptosis induced by activated microglia.
Based on the results, researchers wrote, " sulforaphane-enriched broccoli sprouts improved the scopolamine-induced memory impairment in mice through Nrf2 activation, inhibiting neuronal apoptosis, particularly through inhibition of caspase-3 activation which could lead to the neuroprotection against neurodegenerative disorders".
In other words, SFN protects the integrity of the neurons against neuron damage through its anti-neuroinflammatory and neuroprotective activities.
Taken altogether, broccoli sprouts processed abundantly SFN may be considered supplements for the prevention of neurodegenerative disease, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sulforaphane-Enriched Broccoli Sprouts Pretreated by Pulsed Electric Fields Reduces Neuroinflammation and Ameliorates Scopolamine-Induced Amnesia in Mouse Brain through Its Antioxidant Ability via Nrf2-HO-1 Activation by Subedi L1, Cho K1, Park YU2, Choi HJ2, Kim SY. (PubMed)
(2) Aging and neurodegenerative diseases by Hung CW1, Chen YC, Hsieh WL, Chiou SH, Kao CL. (PubMed)
Serum #Carotenoids Are Associated Inversely with the Risk of #BreastCancer, According to Study
Kyle J. Norton
Breast cancer or malignant breast neoplasm is a medical condition caused by cell growth irregularly in the tissue of the breast.
Most cases of breast cancer start in the cell on the surface of the inner lining tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.
Breast cancer is the most common cancer worldwide, accounting for over 24% of all cancers diagnosed every year.
The 5 years survival rate of breast cancer in the localized stage is about 100%.
Inflammatory breast cancer (IBC), is aggressive cancer that occurs in women of any age that grows in sheets instead of lumps and invades nearby skin, leading to the whole breast suddenly goes red and feeling hot, resembling an inflammation
The rare condition was found in only 1-6% of all breast cancer cases in the USA. Inflammatory breast cancer (IBC) should be treated very promptly.
The most common symptoms of IBC are
* Rapid swelling (a cup size in a few days) sometimes
* Skin changes (pink, red, or dark-colored areas)
* Nipple retraction
* Persistent itching, skin hot to touch
* Initially resembles mastitis
* Breast skin ulcers (later stage of IBC)
How dangerous is IBC? Dr. Ana M. Gonzalez-Angulo, the lead scientist wrote, " (According to the results of the study), the median follow-up was 5.8 years (range, 0.3–23.8 years). There were 238 recurrences and 236 deaths (compared to 398 patients with IBC who were treated between 1974 and 2005). The median recurrence-free survival (RFS) duration was 2.3 years and the median overall survival (OS) time was 4.2 years".
Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
In finding a potential compound for the treatment of cancer, researchers examined the protective role of carotenoids against the onset of breast cancer.
The study included a total of 521 women with breast cancer and age-matched controls (5-year interval) selected from three teaching hospitals in Guangzhou, China.
According to the chemical analysis, phytochemicals α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein/zeaxanthin are found in serum carotenoids,
* Serum α-carotene, β-carotene, lycopene, and lutein/zeaxanthin are associated inversely with the risk of breast cancer.
* The relative odds ratio for the highest quartile of serum concentration compared with the lowest quartile were 0·44.
* More precisely, the OR for α-carotene was.44, β-carotene was 0·27 and lycopene was .41, and lutein/zeaxanthin was 0·26.
* β-cryptoxanthin, one of the major compounds was not significantly associated with the risk for breast cancer.
Based on the stratified analysis, researchers found that serum α-carotene, β-carotene, lycopene, and lutein/zeaxanthin were also inversely associated with breast cancer risk among premenopausal women and among all subtypes of ER or PR status.
The results strongly suggested that all chemical compounds in the class of carotenoids work synergistically to decrease the risk of cancer among women.
Dr. Yan B, the lead scientist, after taking other factors into account said, "The results suggest a protective role of α-carotene, β-carotene, lycopene, and lutein/zeaxanthin, but not β-cryptoxanthin, in breast cancer risk.".
Taken together, carotenoids may be considered a remedy for the prevention and treatment of breast cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Specific serum carotenoids are inversely associated with breast cancer risk among Chinese women: a case-control study by Yan B1, Lu MS1, Wang L1, Mo XF2, Luo WP1, Du YF1, Zhang CX. (PubMed)
(2) Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort by Bakker MF1, Peeters PH2, Klaasen VM3, Bueno-de-Mesquita HB4, Jansen EH5, Ros MM5, Travier N6, Olsen A7, Tjønneland A7, Overvad K8, Rinaldi S9, Romieu I9, Brennan P9, Boutron-Ruault MC10, Perquier F10, Cadeau C10, Boeing H11, Aleksandrova K11, Kaaks R12, Kühn T12, Trichopoulou A13, Lagiou P14, Trichopoulos D15, Vineis P16, Krogh V17, Panico S18, Masala G19, Tumino R20, Weiderpass E21, Skeie G22, Lund E22, Quirós JR23, Ardanaz E24, Navarro C25, Amiano P26, Sánchez MJ27, Buckland G6, Ericson U28, Sonestedt E28, Johansson M29, Sund M30, Travis RC31, Key TJ31, Khaw KT32, Wareham N33, Riboli E34, van Gils CH. (PubMed)
Breast cancer or malignant breast neoplasm is a medical condition caused by cell growth irregularly in the tissue of the breast.
Most cases of breast cancer start in the cell on the surface of the inner lining tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.
Breast cancer is the most common cancer worldwide, accounting for over 24% of all cancers diagnosed every year.
The 5 years survival rate of breast cancer in the localized stage is about 100%.
Inflammatory breast cancer (IBC), is aggressive cancer that occurs in women of any age that grows in sheets instead of lumps and invades nearby skin, leading to the whole breast suddenly goes red and feeling hot, resembling an inflammation
The rare condition was found in only 1-6% of all breast cancer cases in the USA. Inflammatory breast cancer (IBC) should be treated very promptly.
The most common symptoms of IBC are
* Rapid swelling (a cup size in a few days) sometimes
* Skin changes (pink, red, or dark-colored areas)
* Nipple retraction
* Persistent itching, skin hot to touch
* Initially resembles mastitis
* Breast skin ulcers (later stage of IBC)
How dangerous is IBC? Dr. Ana M. Gonzalez-Angulo, the lead scientist wrote, " (According to the results of the study), the median follow-up was 5.8 years (range, 0.3–23.8 years). There were 238 recurrences and 236 deaths (compared to 398 patients with IBC who were treated between 1974 and 2005). The median recurrence-free survival (RFS) duration was 2.3 years and the median overall survival (OS) time was 4.2 years".
Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
In finding a potential compound for the treatment of cancer, researchers examined the protective role of carotenoids against the onset of breast cancer.
The study included a total of 521 women with breast cancer and age-matched controls (5-year interval) selected from three teaching hospitals in Guangzhou, China.
According to the chemical analysis, phytochemicals α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein/zeaxanthin are found in serum carotenoids,
* Serum α-carotene, β-carotene, lycopene, and lutein/zeaxanthin are associated inversely with the risk of breast cancer.
* The relative odds ratio for the highest quartile of serum concentration compared with the lowest quartile were 0·44.
* More precisely, the OR for α-carotene was.44, β-carotene was 0·27 and lycopene was .41, and lutein/zeaxanthin was 0·26.
* β-cryptoxanthin, one of the major compounds was not significantly associated with the risk for breast cancer.
Based on the stratified analysis, researchers found that serum α-carotene, β-carotene, lycopene, and lutein/zeaxanthin were also inversely associated with breast cancer risk among premenopausal women and among all subtypes of ER or PR status.
The results strongly suggested that all chemical compounds in the class of carotenoids work synergistically to decrease the risk of cancer among women.
Dr. Yan B, the lead scientist, after taking other factors into account said, "The results suggest a protective role of α-carotene, β-carotene, lycopene, and lutein/zeaxanthin, but not β-cryptoxanthin, in breast cancer risk.".
Taken together, carotenoids may be considered a remedy for the prevention and treatment of breast cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Specific serum carotenoids are inversely associated with breast cancer risk among Chinese women: a case-control study by Yan B1, Lu MS1, Wang L1, Mo XF2, Luo WP1, Du YF1, Zhang CX. (PubMed)
(2) Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort by Bakker MF1, Peeters PH2, Klaasen VM3, Bueno-de-Mesquita HB4, Jansen EH5, Ros MM5, Travier N6, Olsen A7, Tjønneland A7, Overvad K8, Rinaldi S9, Romieu I9, Brennan P9, Boutron-Ruault MC10, Perquier F10, Cadeau C10, Boeing H11, Aleksandrova K11, Kaaks R12, Kühn T12, Trichopoulou A13, Lagiou P14, Trichopoulos D15, Vineis P16, Krogh V17, Panico S18, Masala G19, Tumino R20, Weiderpass E21, Skeie G22, Lund E22, Quirós JR23, Ardanaz E24, Navarro C25, Amiano P26, Sánchez MJ27, Buckland G6, Ericson U28, Sonestedt E28, Johansson M29, Sund M30, Travis RC31, Key TJ31, Khaw KT32, Wareham N33, Riboli E34, van Gils CH. (PubMed)
#Fennel #EssentialOil Processes a Strong Antibacterial and Antioxidant Activity, Scientists Suggest
Kyle J. Norton
Fennel may be the next generative functional food with the potency in blocking the overexpression of free radicals in the induction of chronic illness, some scientists suggested.
Free radicals are highly reactive molecules with unpaired electrons that cause oxidation by stealing an electron from other molecules to give rise to a chain activity. Once free radical starts its domino effect, it can not be stopped until two free radical species react with each other to form a stable, non-radical adduct or are inhibited by the presence of antioxidants.
Antioxidants, on the other hand, are stable molecules that inhibit oxidation caused by free radicals.
The relationship between free radicals and antioxidants is summarized by Dr. V. Lobo, the lead author in the study "Free radicals, antioxidants, and functional foods: Impact on human health ", "A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues. Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. Hence the application of an external source of antioxidants can assist in coping with this oxidative stress".
These explanations suggested that the intake of antioxidants from the food sources in the stimulation of antioxidant enzymes in the body is benefits in maintaining good health, However, the doctors continued, "Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health. Thus, the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years".
Overexpression of free radicals or imbalance of the ratio of free radicals and antioxidants in the body can initiate oxidative stress. A prolonged period of oxidative stress in the human body plays a major part in the development of chronic and degenerative illnesses such as cancer, autoimmune disorders, aging, cataracts, rheumatoid arthritis, and cardiovascular and neurodegenerative diseases.
Fennel (Foeniculum vulgare) is a plant species of the genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The functional herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, relieve PMS,...
Fennel is an excellent source of natural antioxidants and contributes to the daily antioxidant diet. The functional food is found to process a free radical scavenging activity, particularly in the application of its phenolic and flavonoids.
In the examination of the effects of fennel essential oil in the presence of overexpression of free radicals, researchers found, that injection of the oil exerts a strong antioxidant activity in comparison with butylated hydroxyanisole and butylated hydroxytoluene., however, injection of ethanol and water extracts of fennel showed less effective compared to essential oil.
Furthermore, in the evaluation of the essential oils of the fruits of three organically grown cultivars of Egyptian fennel (Foeniculum vulgare var. azoricum, Foeniculum vulgare var. dulce and Foeniculum vulgare var. vulgare) in antibacterial and antioxidant effects, researchers showed that all three cultivars contain a great source of trans-Anethole, estragole, fenchone, and limonene.
All phytochemicals demonstrated significant activity in free radical scavenging, inhibited lipid peroxidation, and metal chelation.
Additional differentiation suggested that essential oils from the azoricum and dulce cultivars were more effective antioxidants than those from the vulgare cultivar and essential oils from 3 species display similar antimicrobial activities against two species of fungi, two species of Gram-negative and two species of Gram-positive bacteria.
More importantly, in the examine the effect of essential oil on fennel (Foeniculum vulgare) lipophilic secondary metabolites, researchers at the Avicenna Tajik State Medical University discovered that
* The oil exhibited moderate antioxidant activities.
* The antioxidants in the essential oil are found to protect the healthy cells and stimulate the expression of free radicals in exerting cytotoxic activity against HeLa (human cervical cancer), Caco-2 (human colorectal adenocarcinoma), MCF-7 (human breast adenocarcinoma), CCRF-CEM (human T lymphoblast leukemia) and CEM/ADR5000 (adriamycin resistant leukemia) cancer cell lines;
* The most effective of the IC50 values are between 30-210 mg L-1.
These results suggested essential oil from fennel processed is a great source of antioxidants with the function of balancing the ratio of free radicals in the body, thus preventing the initiation of oxidative stress.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Chemical composition, antimicrobial and antioxidant activities of essential oils from organically cultivated fennel cultivars by Shahat AA1, Ibrahim AY, Hendawy SF, Omer EA, Hammouda FM, Abdel-Rahman FH, Saleh MA(PubMed)
(3) Cytotoxicity of the Essential Oil of Fennel (Foeniculum vulgare) from Tajikistan by Sharopov F1,2, Valiev A3, Satyal P4, Gulmurodov I5, Yusufi S6, Setzer WN7, Wink M8(PubMed)
(4) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)
Fennel may be the next generative functional food with the potency in blocking the overexpression of free radicals in the induction of chronic illness, some scientists suggested.
Free radicals are highly reactive molecules with unpaired electrons that cause oxidation by stealing an electron from other molecules to give rise to a chain activity. Once free radical starts its domino effect, it can not be stopped until two free radical species react with each other to form a stable, non-radical adduct or are inhibited by the presence of antioxidants.
Antioxidants, on the other hand, are stable molecules that inhibit oxidation caused by free radicals.
The relationship between free radicals and antioxidants is summarized by Dr. V. Lobo, the lead author in the study "Free radicals, antioxidants, and functional foods: Impact on human health ", "A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues. Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. Hence the application of an external source of antioxidants can assist in coping with this oxidative stress".
These explanations suggested that the intake of antioxidants from the food sources in the stimulation of antioxidant enzymes in the body is benefits in maintaining good health, However, the doctors continued, "Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health. Thus, the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years".
Overexpression of free radicals or imbalance of the ratio of free radicals and antioxidants in the body can initiate oxidative stress. A prolonged period of oxidative stress in the human body plays a major part in the development of chronic and degenerative illnesses such as cancer, autoimmune disorders, aging, cataracts, rheumatoid arthritis, and cardiovascular and neurodegenerative diseases.
Fennel (Foeniculum vulgare) is a plant species of the genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The functional herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, relieve PMS,...
Fennel is an excellent source of natural antioxidants and contributes to the daily antioxidant diet. The functional food is found to process a free radical scavenging activity, particularly in the application of its phenolic and flavonoids.
In the examination of the effects of fennel essential oil in the presence of overexpression of free radicals, researchers found, that injection of the oil exerts a strong antioxidant activity in comparison with butylated hydroxyanisole and butylated hydroxytoluene., however, injection of ethanol and water extracts of fennel showed less effective compared to essential oil.
Furthermore, in the evaluation of the essential oils of the fruits of three organically grown cultivars of Egyptian fennel (Foeniculum vulgare var. azoricum, Foeniculum vulgare var. dulce and Foeniculum vulgare var. vulgare) in antibacterial and antioxidant effects, researchers showed that all three cultivars contain a great source of trans-Anethole, estragole, fenchone, and limonene.
All phytochemicals demonstrated significant activity in free radical scavenging, inhibited lipid peroxidation, and metal chelation.
Additional differentiation suggested that essential oils from the azoricum and dulce cultivars were more effective antioxidants than those from the vulgare cultivar and essential oils from 3 species display similar antimicrobial activities against two species of fungi, two species of Gram-negative and two species of Gram-positive bacteria.
More importantly, in the examine the effect of essential oil on fennel (Foeniculum vulgare) lipophilic secondary metabolites, researchers at the Avicenna Tajik State Medical University discovered that
* The oil exhibited moderate antioxidant activities.
* The antioxidants in the essential oil are found to protect the healthy cells and stimulate the expression of free radicals in exerting cytotoxic activity against HeLa (human cervical cancer), Caco-2 (human colorectal adenocarcinoma), MCF-7 (human breast adenocarcinoma), CCRF-CEM (human T lymphoblast leukemia) and CEM/ADR5000 (adriamycin resistant leukemia) cancer cell lines;
* The most effective of the IC50 values are between 30-210 mg L-1.
These results suggested essential oil from fennel processed is a great source of antioxidants with the function of balancing the ratio of free radicals in the body, thus preventing the initiation of oxidative stress.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Chemical composition, antimicrobial and antioxidant activities of essential oils from organically cultivated fennel cultivars by Shahat AA1, Ibrahim AY, Hendawy SF, Omer EA, Hammouda FM, Abdel-Rahman FH, Saleh MA(PubMed)
(3) Cytotoxicity of the Essential Oil of Fennel (Foeniculum vulgare) from Tajikistan by Sharopov F1,2, Valiev A3, Satyal P4, Gulmurodov I5, Yusufi S6, Setzer WN7, Wink M8(PubMed)
(4) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)
#Healthyfood #Beets and #Carrots Inhibit Parameters Associated with the Production of Pro-Inflammatory Cytokines and Fatty Liver Tissues, According to Studiesnm
Kyle J. Norton
A fatty liver is a liver condition associated with the accumulation of excess fat in the liver.
Non-alcoholic fatty liver (NAFL) is the early stage of nonalcoholic steatohepatitis (NASH) caused by the accumulation of fat in the liver, other than excessive use of alcohol.
Nonalcoholic steatohepatitis (NASH) is a type of inflammatory non-alcoholic fatty liver disease caused by excessive fat accumulated in the liver.
Nonalcoholic steatohepatitis (NASH) is asymptomatic until the condition is developed into cirrhosis, the condition that causes advanced liver scars, and reduces the performance of the liver.
In other words, if more than 5% – 10% percent of your liver’s weight is fat, you have a fatty liver (steatosis).
According to the statistics, non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of liver disease affecting 100 million people in the US. Out of that number, approximately 20% of people have NASH.
Medical conditions such as obesity, metabolic syndrome, and type 2 diabetes are some of the metabolic risk factors that have been found to induce the development of NASH.
As of today, there is no effective treatment for NASH. Depending on the condition people with overweight or obese are recommended to lose weight. The aim of medical treatment is to reduce the symptoms delay the progression of the condition and improve the quality of life.
Out of many prevalent factors that cause the onset of NASH, some researchers suggested that the promotion of a high-fat diet over the past few decades induced a high percentage of the overweight and obese population may be the major culprit associated with the rise of NASH.
Dr. Jensen VS, the lead scientist wrote, "Hepatic dysfunction and inflammation were confirmed in HFD-fed rats by elevated levels of hepatic MCP-1 (p < 0.0001), TNF-alpha (p < 0.001) and plasma β-hydroxybutyrate (p < 0.0001), and in NASH-fed rats by elevated levels of hepatic MCP-1 (p < 0.01), increased hepatic macrophage infiltration (p < 0.001), and higher plasma levels of alanine aminotransferase (p < 0.0001) aspartate aminotransferase (p < 0.05), haptoglobin (p < 0.001) and TIMP-1 (p < 0.01) compared to Control".
And, " dietary fat and cholesterol are the primary drivers of NAFLD development and progression in rats, while fructose mostly exerts its effect on the circulating lipid pool".
Betaxanthins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, Sicilian prickly pear, etc.
In finding a potent ingredient for the treatment of liver disease, researchers examined the protecting effects of bioactive agents of the lyophilized table beet and carrot powder on fatty liver.
The shorten term study included male Wistar rats fed with chow with or without high fat (2% cholesterol, 0.5% cholic acid, 20% sunflower oil) and treated with 0.1 or 1 g/bwkg/day natural product for ten days parallel with the feedings.
Based on the tested analysis, compared to other feedings, the higher dose of the natural product better decreased the induced free radical reactions, cyclooxygenase-2, and proteins associated with the production of pro-inflammatory cytokines in normal and fatty liver tissues.
More precisely, the natural treatment of beet and carrot powder inhibited liver oxidative stress by inhibiting the inflammatory expression without causing significant changes in all global antioxidant parameters.
However, the antioxidant activity of mobilized methyl group concentrations associated with liver stress also increased by fatty liver tissues.
Based on the evidence, researchers said, "Beet and carrot proved to be a "functional food" in rats with alimentary fat-induced fatty liver. It cannot be ruled out that this beneficial effect may have clinical relevance".
Taken together, beet and carrot may be considered functional remedies for the prevention of fatty liver disease, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Experimental food-induced fatty liver and its adjuvant therapy with natural bioactive substances].
[Article in Hungarian] by Hegedüs V1, Gerö D, Mihály Z, Szijártó A, Zelles T, Sárdi E. (PubMed)
A fatty liver is a liver condition associated with the accumulation of excess fat in the liver.
Non-alcoholic fatty liver (NAFL) is the early stage of nonalcoholic steatohepatitis (NASH) caused by the accumulation of fat in the liver, other than excessive use of alcohol.
Nonalcoholic steatohepatitis (NASH) is a type of inflammatory non-alcoholic fatty liver disease caused by excessive fat accumulated in the liver.
Nonalcoholic steatohepatitis (NASH) is asymptomatic until the condition is developed into cirrhosis, the condition that causes advanced liver scars, and reduces the performance of the liver.
In other words, if more than 5% – 10% percent of your liver’s weight is fat, you have a fatty liver (steatosis).
According to the statistics, non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of liver disease affecting 100 million people in the US. Out of that number, approximately 20% of people have NASH.
Medical conditions such as obesity, metabolic syndrome, and type 2 diabetes are some of the metabolic risk factors that have been found to induce the development of NASH.
As of today, there is no effective treatment for NASH. Depending on the condition people with overweight or obese are recommended to lose weight. The aim of medical treatment is to reduce the symptoms delay the progression of the condition and improve the quality of life.
Out of many prevalent factors that cause the onset of NASH, some researchers suggested that the promotion of a high-fat diet over the past few decades induced a high percentage of the overweight and obese population may be the major culprit associated with the rise of NASH.
Dr. Jensen VS, the lead scientist wrote, "Hepatic dysfunction and inflammation were confirmed in HFD-fed rats by elevated levels of hepatic MCP-1 (p < 0.0001), TNF-alpha (p < 0.001) and plasma β-hydroxybutyrate (p < 0.0001), and in NASH-fed rats by elevated levels of hepatic MCP-1 (p < 0.01), increased hepatic macrophage infiltration (p < 0.001), and higher plasma levels of alanine aminotransferase (p < 0.0001) aspartate aminotransferase (p < 0.05), haptoglobin (p < 0.001) and TIMP-1 (p < 0.01) compared to Control".
And, " dietary fat and cholesterol are the primary drivers of NAFLD development and progression in rats, while fructose mostly exerts its effect on the circulating lipid pool".
Betaxanthins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, Sicilian prickly pear, etc.
In finding a potent ingredient for the treatment of liver disease, researchers examined the protecting effects of bioactive agents of the lyophilized table beet and carrot powder on fatty liver.
The shorten term study included male Wistar rats fed with chow with or without high fat (2% cholesterol, 0.5% cholic acid, 20% sunflower oil) and treated with 0.1 or 1 g/bwkg/day natural product for ten days parallel with the feedings.
Based on the tested analysis, compared to other feedings, the higher dose of the natural product better decreased the induced free radical reactions, cyclooxygenase-2, and proteins associated with the production of pro-inflammatory cytokines in normal and fatty liver tissues.
More precisely, the natural treatment of beet and carrot powder inhibited liver oxidative stress by inhibiting the inflammatory expression without causing significant changes in all global antioxidant parameters.
However, the antioxidant activity of mobilized methyl group concentrations associated with liver stress also increased by fatty liver tissues.
Based on the evidence, researchers said, "Beet and carrot proved to be a "functional food" in rats with alimentary fat-induced fatty liver. It cannot be ruled out that this beneficial effect may have clinical relevance".
Taken together, beet and carrot may be considered functional remedies for the prevention of fatty liver disease, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Experimental food-induced fatty liver and its adjuvant therapy with natural bioactive substances].
[Article in Hungarian] by Hegedüs V1, Gerö D, Mihály Z, Szijártó A, Zelles T, Sárdi E. (PubMed)
#Prickly Pear Juice Chemical Compounds #Exert Anti-Cancer Activity through Their Antioxidant Activity, Researchers Show
Kyle J. Norton
Cancer is a group of diseases caused by the alternation of a group of cells' DNA.
Most cases of cancer begin in the cells on the surface of the inner lining of the tissue of an organ. At early, most people with cancer are asymptomatic.
At the later stage, patients may experience general cancer symptoms such as unintended weight loss, fatigue, gastrointestinal discomfort, and loss of appetite, and localized symptoms such as severe pain and bleeding.
The exact causes of cancer are not identified. However, the most prevalent factors associated with cancer onset include age, family history, long-term exposure to certain cancer-induced chemicals, use of tobacco, and excessive alcohol drinking,..... the list goes on and on, depending on the type of cancer.
Some researchers suggested that the most common risk factor that causes cancer in the Western world may be associated with widespread obesity.
Dr. Karen Basen-Engquist, in the evaluation of the obesity risk of cancer, said, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%".
And, "High priorities for future research involve additional work on the underlying mechanisms, and trials to examine the effect of lifestyle behavior change and weight loss interventions on cancer and intermediate biomarkers".
The findings strongly indicated the risk of cancer is increased substantially in obese.
Prickly pear is a genus in the cactus family, Cactaceae belongs to the Kingdom Plantae native to Australia.
According to the Mayo Clinic, prickly pear processes prickly pear anti-type 2 diabetes and anti-inflammatory activity.
In finding a potent ingredient for the treatment of cancer, researchers examined the effects of Juices of nine prickly pears (Opuntia spp.) in vitro against four cancer cell lines.
Based on the tested assays, betaxanthins and other chemical compounds found in the juices of nine prickly pears (Opuntia spp.) exerted an anti-cytotoxic activity ranging from 22 to 226 microg gallic acid eq/g, 95 to 374 microg quercetin eq/g, 3 to 189 microg/g, 1.6 to 300 microg/g and 17 to 25 micromoles Trolox eq./mL.
Furthermore, the juices showed strong anti-cancer effects, particularly in prostate and colon cell lines.
without affecting mammary or hepatic cancer cells.
In other words, the efficacy of prickly pears in the induction of antioxidants and inhibition of cancer totally depends on the juice properties and phytochemicals that could prevent oxidative stress and cancer.
Taken together, prickly pear may be considered a functional remedy for the prevention of cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phenolic composition, antioxidant capacity and in vitro cancer cell cytotoxicity of nine prickly pear (Opuntia spp.) juices by Chavez-Santoscoy RA1, Gutierrez-Uribe JA, Serna-Saldívar SO. (PubMed)
Cancer is a group of diseases caused by the alternation of a group of cells' DNA.
Most cases of cancer begin in the cells on the surface of the inner lining of the tissue of an organ. At early, most people with cancer are asymptomatic.
At the later stage, patients may experience general cancer symptoms such as unintended weight loss, fatigue, gastrointestinal discomfort, and loss of appetite, and localized symptoms such as severe pain and bleeding.
The exact causes of cancer are not identified. However, the most prevalent factors associated with cancer onset include age, family history, long-term exposure to certain cancer-induced chemicals, use of tobacco, and excessive alcohol drinking,..... the list goes on and on, depending on the type of cancer.
Some researchers suggested that the most common risk factor that causes cancer in the Western world may be associated with widespread obesity.
Dr. Karen Basen-Engquist, in the evaluation of the obesity risk of cancer, said, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%".
And, "High priorities for future research involve additional work on the underlying mechanisms, and trials to examine the effect of lifestyle behavior change and weight loss interventions on cancer and intermediate biomarkers".
The findings strongly indicated the risk of cancer is increased substantially in obese.
Prickly pear is a genus in the cactus family, Cactaceae belongs to the Kingdom Plantae native to Australia.
According to the Mayo Clinic, prickly pear processes prickly pear anti-type 2 diabetes and anti-inflammatory activity.
In finding a potent ingredient for the treatment of cancer, researchers examined the effects of Juices of nine prickly pears (Opuntia spp.) in vitro against four cancer cell lines.
Based on the tested assays, betaxanthins and other chemical compounds found in the juices of nine prickly pears (Opuntia spp.) exerted an anti-cytotoxic activity ranging from 22 to 226 microg gallic acid eq/g, 95 to 374 microg quercetin eq/g, 3 to 189 microg/g, 1.6 to 300 microg/g and 17 to 25 micromoles Trolox eq./mL.
Furthermore, the juices showed strong anti-cancer effects, particularly in prostate and colon cell lines.
without affecting mammary or hepatic cancer cells.
In other words, the efficacy of prickly pears in the induction of antioxidants and inhibition of cancer totally depends on the juice properties and phytochemicals that could prevent oxidative stress and cancer.
Taken together, prickly pear may be considered a functional remedy for the prevention of cancer, pending the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phenolic composition, antioxidant capacity and in vitro cancer cell cytotoxicity of nine prickly pear (Opuntia spp.) juices by Chavez-Santoscoy RA1, Gutierrez-Uribe JA, Serna-Saldívar SO. (PubMed)
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