#Phytochemical Sulforaphane (Dithiolthiones) Inhibits Parameters Associated with the Risk of #LiverDisease, According to Studies

Kyle J. Norton

Scientists may have found a natural ingredient for the prevention and treatment of liver disease with no side effects, according to studies.

Liver disease in most cases is linked to alcohol or drugs. In fact, it can be caused by a variety of factors and affects everyone from infants to older adults, including infected viruses such as hepatitis A, B, C, and medication overload.

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

The most common symptoms of liver disease include weakness and fatigue, weight loss, nausea, vomiting, and jaundice.

If you are experiencing some of the above symptoms, please make sure you check with your doctor to rule out the possibility of liver disease.

According to the statistic provided by the Canadian Liver Foundation, approximately, one in 10 Canadians, or more than three million people, have some form of liver disease and over a period of only eight years, the death rate from liver disease has risen nearly 30%.

These incidences of liver disease not only lead to dismissing the quality of life and life expectancy but also cause a financial burden on the health care system.

Conventional treatment of liver disease depends on your diagnosis. Most cases of liver disease can be treated with lifestyle modifications, such as stopping alcohol use in alcoholic fatty liver disease or losing weight, in nonalcoholic liver disease.

Dr. Valerio Nobili, the lead scientist in the examined the role of lifestyle changes in the management of chronic liver disease, said, "several liver conditions which are directly affected by overweight and obese status, including non-alcoholic fatty liver disease, chronic infection with hepatitis C virus and post-liver transplant status".

And, "The deleterious effects of obesity on liver disease and overall health can be significantly impacted by a culture that fosters sustained nutritional improvement and regular physical activity".

With an aim to find a natural ingredient for the treatment of liver disease, researchers evaluated the ability of sulforaphane, an activator of Nrf2, to blunt CYP2E1-dependent, ethanol-induced steatosis in vivo and in vitro.


Where Nuclear factor (erythroid-derived 2)-like 2, (Nrf2), is a pro- antioxidant protein that plays a critical role in protecting our body against oxidative damage triggered by injury and inflammation.

CYP2E1 is a protein involved in the metabolism of xenobiotics in the body.

The application of sulforaphane (SFN) treatment increased the levels of antioxidants by activating the levels of the Nrf2 and lowering oxidant stress observed by the decline in lipid peroxidation and increase in glutathione (GSH) levels.

SFN also decreased liver levels of triglycerides and cholesterol elevated by the injection of ethanol.

The results strongly suggested that SFN inhibited liver disease by increasing the expression of antioxidant enzymes and lowering the expression of free radicals as well as reducing the liver fat deposits.

Moreover, in the investigation to determine whether glucoraphanin and its breakdown product sulforaphane, are potent modulators of various phase I and phase II enzymes involved in carcinogen-metabolizing enzyme systems in vitro, researchers showed that injection of glucoraphanin at higher concentrations (25 μM) decreased dealkylation of methoxyresorufin, a marker for cytochrome P4501 activity

Where cytochrome P4501 is an enzyme involved in the metabolism of endogenous substrates and drugs, as well as the activation of certain toxins and environmental pollutants.

Compared to glucoraphanin, sulforaphane is superior to its precursor in modulating carcinogen-metabolizing enzyme systems in vitro.


The University of Rhode Island, Kingston study also suggested that SF activates Nrf2 activation in inhibited lipid accumulation in white adipose tissue, suppressed adipogenesis, insulin resistance, and glucose intolerance, and hepatic steatosis in Lep(ob/ob) mice.

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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis by Zhou R1, Lin J, Wu D.(PubMed)
(2) Sulforaphane is superior to glucoraphanin in modulating carcinogen-metabolizing enzymes in Hep G2 cells by Abdull Razis AF1, Noor NM. (PubMed)
(3) Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice by Xu J1, Kulkarni SR, Donepudi AC, More VR, Slitt AL. (PubMed)
(4) The role of lifestyle changes in the management of chronic liver disease by Valerio Nobili, Christine Carter-Kent,2 and Ariel E Feldstein. (PMC)

#Inicaxanthin Regulates Enzymes and Proteins Associated with the Production of Pro-inflammatrry Cytokines, Researchers Suggest

Kyle J. Norton

Inflammation is a natural defense of the immune system that protects the body against the invasion of harmful stimuli and pathogens.
Anti-inflammatory activity is the process of reducing inflammation or swelling without affecting the function of the immune system.

In the acute phase of infection, the immune first line of defense, the white blood cells, macrophages stimulates the production of blood platelets to cover the wound or cut and proinflammatory cytokines to destroy all invaders.

Most cases of acute infection are stopped at this phase and the wound is healed quickly.

However, if the wound is too large, then the recovery may take a longer period and through 4 overlap recovery stages. Any interruption in the overlapped recover stage may cause the formation of scars.

Moreover, overproduction of proinflammatory cytokines that kills harmful pathogens may cause damage and death of nearby healthy cells, leading to the formation of scars, such as scar in the liver caused by hepatitis infection.

Additionally, if the immune system can not destroy the invasive pathogens in a set of times, it will compromise, leading to low-grade inflammation. Prolonged low-grade inflammation caused by continuing the production of pro-inflammatory cytokines can result in serious and chronic diseases.

Diseases associated with chronic inflammation induced by protein, lipid and cellular damage include cardiovascular disease, diabetes, neurodegenerative disease,... and cancers.

The results have been found to cause cell death and alternation of cell DNA.
In finding a potent compound that processes anti-inflammatory property, researchers investigated the activity of indicaxanthin, in an animal model of acute inflammation.

According to the tested differentiation of rats induced by injection of 0.2 mL of λ-carrageenin in the pleural cavity pretreated by indicaxanthin at 2 μmol/kg,

* Pretreatment of the phytochemical inhibited the release of pro-inflammatory PGE(2) (91.4%), NO (67.7%), IL-1β (53.6%), and TNF-α (71.1%) induced by carrageenan-induced rats.


* Furthermore, enzymes and proteins associated with the production of proinflammatory cytokines such as IL-1β (34.5%), TNF-α (81.6%), iNOS (75.2%), and COX2 (87.7%) mRNA were also inhibited by the pretreatment of indicaxanthin.

* iNOS (71.9%) and COX-2 (65.9%) enzyme expressions involved in the inflammatory processes that recruit the leukocytes are also inhibited by the bioactive compound.

* Moreover, enzymes associated with the induction of free radicals chain reaction were also curbed by the indicaxanthin at a time- and dose-dependently.

Pharmacokinetically, the most efficacy in inhibition of inflammation was found to have a maximum 0.22 ± 0.02 μmol/L (n = 15) plasma concentration of indicaxanthin, with a half-life of 1.15 ± 0.11 h.


Based on the findings, researchers said, "This dietary pigment has the potential to improve health and prevent inflammation-based disorders".

Taken together, indicaxanthin may be considered a remedy for the prevention and treatment of inflammation, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Indicaxanthin from cactus pear fruit exerts anti-inflammatory effects in carrageenin-induced rat pleurisy by Allegra M1, Ianaro A, Tersigni M, Panza E, Tesoriere L, Livrea MA. (PubMed)
(2) Indicaxanthin inhibits NADPH oxidase (NOX)-1 activation and NF-κB-dependent release of inflammatory mediators and prevents the increase of epithelial permeability in IL-1β-exposed Caco-2 cells by Tesoriere L1, Attanzio A1, Allegra M1, Gentile C1, Livrea MA. (PubMed)

#CranberryExtract Improves Metabolic Profile induced by Lipid Dysfunction of #Obesity, According to Studies

Kyle J. Norton

A metabolic profile is a tool to diagnose metabolic disease.
A metabolic disease is a group of medical conditions that disrupt normal cell metabolism in converting food to energy.
The most common causes of metabolic disease are genetic prepositions. However, people with the mutated gene remain healthy for years.

Interestingly, cellular stress and family history have been found to be a major cause of the initiation of the symptoms of metabolic disease, epidemiologically.

As of today, there is no effective treatment for metabolic disease. Some children with metabolic disease diagnosed at an early age may respond very well. However, many do not respond well to therapy and cause severe problems, despite the early diagnosis.

Dr. Ingraham RH, the lead scientist at the Louisiana State University School of Veterinary Medicine wrote, "Except in cases of gross mismanagement, these profiles do not offer a "quick fix." In many of the reported cases in which diagnosis of herd problems was attributed to the metabolic profile, the clinician should have been able to identify the problem before the profile was conducted".

According to statistics, the metabolic disease is uncommon in the US. Metabolic disorders affect approximately 1 in 1,000 individuals.

People who are overweight and obesity and physical inactivity and have a condition of insulin resistance are most likely to have metabolic disease developing.

According to the statistics, among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35%. From 1988–1994 to 2007–2012, the condition increased from 25.3% to 34.2%.

Out of many risk factors associated with the onset of metabolic syndrome, some researchers suggested the promotion of the Western diet over the past few decades may be the major culprit in inducing the rise of the metabolic syndrome, globally.

Hypertension is a condition of abnormally high blood pressure in the bloodstream. Hypertension a member of the cluster conditions of metabolic syndrome associated with an increased risk of cardiovascular disease and diabetes.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.
According to the statistics provided by the American Heart Association, approximately, 103 million U.S. adults have high blood pressure, or 1 in 2 adults in the US have the syndrome.

Obesity is a medical and chronic condition caused by long-term excessive body fat accumulated. Overweight is a condition of excess body weight relative to height.


According to the Body Mass Index(BMI), people who have a BMI between 25 to 29.9 are considered overweight and a BMI of over 30 is an indication of obesity.

The formula of the BMI indexBMI= weight (kg)/ height (m2)

According to the statistics, 68% of the American population is either overweight or obese. However,

in 2016, more than 1.9 billion adults, 18 years and older, were overweight, inclduing over 650 million who were obese worldwide.

Dr. Shu-Zhong Jiang, the lead scientist wrote in the examination of the metabolic profile of the obese, "There are currently over 1.9 billion people who are obese or overweight, leading to a rise in related health complications, including insulin resistance, type 2 diabetes, cardiovascular disease, liver disease, cancer, and neurodegeneration".

And, "The finding that obesity and metabolic disorder are accompanied by chronic low-grade inflammation has fundamentally changed our view of the underlying causes and progression of obesity and metabolic syndrome".

The results strongly suggested that obese subjects are at an increased risk of metabolic disease.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the treatment of hypercholesterolemia, researchers examined the effect of cranberry extract (CE) on the improvement of lipid dysfunction in HFD-induced obesity in an animal model.

The study included postnatal day 120 (PN120), male Wistar rats assigned into two groups: (1) SD (n = 36) fed with a standard diet and (2) HFD (n = 36), fed with a diet containing 44.5% (35.2% from lard) energy from fat.

According to the results from rats 12 animals from SD and HFD groups were killed at at At PN150 and others subdivided into four groups (n = 12/group): animals that received 200 mg/kg cranberry extract (SD CE, HFD CE) gavage/daily/30 days or water (SD, HFD) killed at PN180, HFD group showed higher body mass and visceral fat, cholesterol and triglyceride contents.

Furthermore, the HFD group demonstrated a significantly higher lipid peroxidation in plasma and tissues and higher protein carbonylation in the liver and adipose tissue compared to the SD group.
Application of CE not only inhibited the aforementioned parameters induced by a high-fat diet but also protected the liver tissues against by lowering lipid peroxidation and protein carbonylation and accumulation of liver fat without completely reversing the adiposity.

Based on the findings, researchers aid, "cranberry extract improved the metabolic profile and reduced oxidative damage and steatosis in HFD-fed rats, which suggests that it can help manage obesity-related disorders".

Taken together, cranberry may be considered a remedy for the improvement of the metabolic profile of obesity, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best BeforeKarate it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Cranberry (Vaccinium macrocarpon) extract treatment improves triglyceridemia, liver cholesterol, liver steatosis, oxidative damage and corticosteronemia in rats rendered obese by high fat diet by Peixoto TC1, Moura EG1, de Oliveira E1, Soares PN1, Guarda DS1, Bernardino DN1, Ai XX1, Rodrigues VDST1, de Souza GR2, da Silva AJR2, Figueiredo MS1, Manhães AC3, Lisboa PC. (PubMed)
(2) Metabolic profile testing by Ingraham RH1, Kappel LC. (PubMed)
(3) Inflammatory mechanisms linking obesity and metabolic disease by Saltiel AR, Olefsky JM. (PubMed)

Betanin/isIsobetanin Inhibits Breast Cell Toxicity Induced Breast Cancer Associated with Oxidative Stress Overtime, Researchers Say

Kyle J. Norton

The breast-formed part of the women's reproductive system is the tissue overlying the chest muscles with a primary function to produce milk for nutrition to the infant and baby.
The size of a woman's breast is totally depending on the amount of fat accumulation.

Breast cancer is a type of cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

However, at the advanced stage, invasive cancer cells can travel a distance away from the breast to infect other healthy tissues and organs via lymph and blood, leading to secondary metastasis.

According to the joint study led by the Unité Génie Enzymatique et Cellulaire, phytochemical isobetanin may process chemopreventive activity against breast cancer.

Isobetanin is a Phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard,...

In MCF-7-treated cells, betanin/isobetanin concentrate exerted anti-cancer activity by significantly decreasingand  cancer cell proliferation and viability.

Betanin/isobetanin concentrates increased the levels of proteins associated with the promotion of apoptosis such as Bad, and p53, and alternated the cancer cell's mitochondrial membrane potential that processed energy storage during oxidative phosphorylation.


Betanin/isobetanin treatment also induced autophagic cell death in the MCF-7 cancer cell line.

According to the statistics, the lifetime risk of breast cancer in a woman is 12%. In the US, approximately 268,600 new cases of invasive breast cancer will be diagnosed in women along with 62,930 new cases of non-invasive (in situ) breast cancer, compared to 2,670 new cases of invasive breast cancer in men in 2019.

The most common symptoms at the early stage of breast cancer are a lump (mass) in the breast, in the armpit (lymph nodes), nipple discharge (clear or bloody), inverted or retracted nipple, scaly or pitted skin on nipple persistent tenderness of the breast and unusual breast pain or discomfort.


However, at the advanced stage, patients with breast cancer may also experience additional symptoms of bone pain (secondary tumors in the bone), shortness of breath (secondary tumors in the lung), unintentional weight loss, and drop in appetite (secondary tumors in the liver) and headaches, neurological pain or weakness (secondary tumors in the nervous system).

The causes of breast cancer are unknown. Out of many risk factors associated with the risk of breast cancer, aging may be a major factor as most breast cancers are diagnosed after age 50.

Dr. Christopher C. Benz wrote, "Early-onset breast cancers largely represent inherited or early life-transforming effects on the immature mammary epithelium, late-onset breast cancers likely follow extended exposures to promoting stimuli of susceptible epithelium that has failed to age normally"


And " late-onset breast cancers grow more slowly and are biologically less aggressive than early-onset breast cancers, even when controlled for hormone receptor (e.g. estrogen receptor, ER) and growth factor receptor (e.g. HER2) expression, supporting the conclusion that the biology of breast cancer is age-dependent".

More precisely, betanin/isobetanin inhibits breast cell toxicity-induced breast cancer caused by accumulated breast tissue damage due to oxidative stress over time.

Based on the finding, researchers said, "Our data bring new insight to consider the betanin/isobetanin mix as a therapeutic anticancer compound, alone or in combination with classical chemotherapeutic drugs, especially in functional p53 tumors".

Taken together, isobetanin combined with betanin/may be considered a remedy for the prevention and treatment of breast cancer, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phytochemicals in quinoa and amaranth grains and their antioxidant, anti-inflammatory, and potential health beneficial effects: A review by Yao Tang and Rong Tsao (Research Gate)
(2) Betanin-Enriched Red Beetroot (Beta vulgaris L.) Extract Induces Apoptosis and Autophagic Cell Death in MCF-7 Cells by Nowacki L1,2, Vigneron P2, Rotellini L2, Cazzola H1, Merlier F1, Prost E1, Ralanairina R3, Gadonna JP3, Rossi C1, Vayssade M. (PubMed)
(3) Impact of aging on the biology of breast cancer by Christopher C. Benz. (PMC)

#Coffee Inhibits Risk Factors Such as Obedity and Depression of Cardiovascular Disease, According to Studies

Kyle J. Norton

Coffee consumers may have one less risk to worry about. A recent study by a well-known institute suggested that long-term and moderate coffee consumption is inversely associated with CVD risk.
Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.

Cardiovascular disease is a medical condition characterized by a heart attack, chest pain (angina), or stroke caused by narrow blood vessels induced block blood.

In the review of literature from the database involved prospective cohort studies of the relationship between coffee consumption and CVD risk, 36 satisfied the guidelines included studies, with 1 279 804 participants and 36 352 CVD cases, coffee drinkers have a nonlinear association with the risk of CVD, depending to numbers of cup intake per day.

According to a joint study led by the Harvard School of Public Health, the relative risk of cardiovascular disease in coffee consumption was .95 in compared with the 0 cups of coffee consumption per day.

Dr. Ding M, the lead author in the review said, "Moderate coffee consumption was inversely significantly associated with CVD risk, with the lowest CVD risk at 3 to 5 cups per day, and heavy coffee consumption was not associated with elevated CVD risk".



In fact, long-term moderate coffee consumption not only reduced the risk of heart disease but also ameliorated other conditions associated with CV risk factors such as obesity and depression. However, the effect of caffeine in lipid files may be associated with endothelial function in increased CVD risk, depending on how the coffee is prepared.

More importantly, epidemiological studies also suggest that risks of mortality in both CV and all causeson are substantially attenuated in regular coffee drinkers.

Furthermore, other researchers insisted that the health benefits of coffee consumption regarding cardiovascular system risk, mostly depend on its antioxidant compounds involved many factors, such as the variety of coffee species, roasting degree, type of brewing method, and serving size.

Since most of the data on coffee's health effects are based on observational data, the risk of high caffeine adverse effects such as anxiety, insomnia, tremulousness, and palpitations have rarely been mentioned, therefore, more randomized, controlled studies are necessary, some researchers suggested.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Long-term coffee consumption and risk of cardiovascular disease: a systematic review and a dose-response meta-analysis of prospective cohort studies by Ding M1, Bhupathiraju SN, Satija A, van Dam RM, Hu FB.(PubMed)
(2) Effects of habitual coffee consumption on cardiometabolic disease, cardiovascular health, and all-cause mortality by O'Keefe JH1, Bhatti SK, Patil HR, DiNicolantonio JJ, Lucan SC, Lavie CJ.(PubMed)

#Phytochemical Indole-3-carbino Inhibits #ProstateCancer through Cell Cycle Arrests and Apoptosis, Reserachers Suggest

Kyle J. Norton

Scientists may have found a bioactive compound isolated from the cruciferous vegetable for the prevention and treatment of prostate cancer with no side effects, according to studies.

Indole-3-carbinol is a phytochemical in the class of Indoles, by the breaking down of the glucosinolate glucobrassicin, found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.

Prostate cancer is a medical and chronic condition in which the cells of the prostate have become cancerous due to the alternation of the cell's DNA.

Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during Physical (rectum) exams.

Primary prostate cancer normally starts from the cell on the surface of the inner lining of the prostate tissue and gradually spreads to the deeper part of the prostate.

At the early stage, patients may not experience any symptoms, However, at the advanced stage, prostate cancer can induce symptoms of blood in the urine, frequent urination, and urinary difficulty.

The cancer cells at this stage can also travel a distance away from the prostate to invade other healthy tissues and organs, leading to secondary metastasis tumors.

According to the statistic, the 5-year survival rate for local and regional (stage 0 and 1) stages of prostate cancer is nearly 100%.

Therefore, men who are at higher risk of prostate cancer due to family history and increase in age and inherited gene changes should have their prostate gland checked annually.

Believe it or not, more than 80% of prostate cancers are diagnosed in men who are 65 or older.

Dr. Roberto Fabiani, the lead scientist at the University of Perugia suggested that people who follow the Western diet pattern are at increased risk of prostate cancer onset.

According to the results from the review of 12 observational studies included in the meta-analysis which identified a “Healthy pattern” and a “Western pattern”, he said, "The Healthy pattern was not related to PC risk (OR = 0.96; 95% confidence interval (CI): 0.88–1.04) while the Western pattern significantly increased it (OR = 1.34; 95% CI: 1.08–1.65)".

In other words, by a change of diet from high in saturated and trans fat, red meat, and processed foods to a diet high in fruits and vegetables and whole grains, the risk of prostate cancer can be reversed.

In order to reaffirm the epidemiological evidence that suggested that intake of cruciferous vegetable intake is associated with a reduced risk of prostate cancer, researchers at the Oregon State University, Corvallis assessed the bioactive compound indole-3-carbinol against the onset of prostate cancer.

In vitro and in vivo. application of indole-3-carbinol inhibits prostate cancer by both blocking initiation and suppressing prostate cancer progression. these results were associated with the induction of phases I and II detoxification pathways.

Injection of indole-3-carbinol inhibited the cell signaling pathways associated with cancer cell proliferation and survival.

Recently, indole-3-carbinol derivatives induced cancer cytotoxicity through induction of free radical expression.

In the laboratory, I3C can induce G1 cell-cycle arrest and apoptosis in prostate cancer cells.

Furthermore, I3C and its derivative dimeric product 3,3'-diindolylmethane (DIM) inhibited the genes associated with the control of cell cycle, cell proliferation, signal transduction, and other cellular processes in prostate cancer cell lines.


Dr. Sarkar FH, the lead scientist, wrote in the final report of the experiment, "Because there is no effective treatment strategy for hormone-dependent and, most importantly, hormone-independent and metastatic prostate cancer, our strategies to sensitize prostate cancer cells to a chemotherapeutic agent by I3C and DIM is a novel breakthrough that could be used for devising novel therapies for prostate cancer".

More importantly, Wayne State University School of Medicine, in a study to confirm that a diet rich in fruits and vegetables provides phytochemicals, launched an investigation to examine the anticancer effect of indole-3-carbinol (I3C).

According to the study, I3C inhibits the growth of PC-3 prostate cancer cells
* through the Induction of G1 cell cycle arrest.

* Promoted the expression of regulators associated with cell cycle progression at G1 and S phase and proteins associated with cancer cell apoptosis.

* Inhibited proteins associated with the progression of cell cycle division

* Inhibited protein in the promotion of proteins associated with cancer cell cycle division.

Taken together, the plant base Indole-3-carbinol isolated from the cruciferous vegetable may be used for the prevention and treatment of prostate cancer with no side effects.
10,000
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

references
(1) Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention. by W Watson G1, M Beaver L, E Williams D, H Dashwood R, Ho E.(PubMed)
(2) Indole-3-carbinol and prostate cancer by Sarkar FH1, Li Y. (PubMed)
(3) Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest, and apoptosis in prostate cancer cells by Chinni SR1, Li Y, Upadhyay S, Koppolu PK, Sarkar FH.(PubMed)
(4) Indole-3-carbinol and 3',3'-diindolylmethane modulate androgen's effect on C-C chemokine ligand 2 and monocyte attraction to prostate cancer cells by Kim EK1, Kim YS, Milner JA, Wang TT. (PubMed)
(5) A Western Dietary Pattern Increases Prostate Cancer Risk: A Systematic Review and Meta-Analysis by Roberto Fabiani,1,* Liliana Minelli,2 Gaia Bertarelli,3 and Silvia Bacci. (PMC)

#Greentea EGCG Exerts a Strong Immunomodulatory Activity, Reserachers Say

Kyle J. Norton

Green tea is found to have a strong immunomodulating effect, affecting the innate and adaptive immune systems, a renowned institute study suggested.

Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including weakened immunity and painful cases of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

According to the Harvard Medical School, epigallocatechin-3-gallate (EGCG) isolated from green tea expressed a strong effect on T cell functions, including T cell activation, proliferation, differentiation, and production of cytokines.

Injection of the phytochemical in the animal model showed significant effects in regulated T cell dysfunction in the expression of autoimmune inflammatory diseases as well as ameliorated T cell-mediated autoimmune diseases.

Furthermore, in naïve CD4(+) T cells proliferate and differentiate into different effector subsets, green tea EGCG inhibited the pro-inflammatory Th1 and Th17 cells, subsets of Th cells responsible for inducing autoimmunity, thus improving symptoms and reducing the pathology of autoimmune diseases.

Additionally, Dr. Wu D, the lead author said, "(The) protective effect EGCG is associated with the suppressed proliferation of autoreactive T cells, in reduced production of pro-inflammatory cytokines of Th1 and Th17, and increased T cell regulation populations in lymphoid tissues and central nervous system".

Further evaluation of green tea EGCG effect in regulated CD4(+) T helper (Th) subsets Th1, Th9, and Th17 cells conducted by the Tufts University, postulated that the phytochemical impeded Th1, Th9, and Th17 differentiation in exhibited inflammation by prevented IL-6(the pro-inflammatory cytokine)-induced suppression of Treg development.

More importantly, in experimental autoimmune encephalomyelitis (EAE) rats, EGCG improved function of CD4(+) T cellsthe  through modulated the expression of IL-6 induced cytokine(gp130) in response to autoimmune function and cellular response.

Taken together, the green tea process has a strong immunomodulating effect in reduced risk and treatment of autoinflammatory and immune disease, but long-term and large amounts of intake should be taken with care to prevent toxicity.


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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published on line, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Immunomodulating effects of epigallocatechin-3-gallate from green tea: mechanisms and applications by Pae M1, Wu D.(PubMed)
(2) Green tea EGCG, T cells, and T cell-mediated autoimmune diseases by Wu D1, Wang J, Pae M, Meydani SN.(PubMed)
(3) Green tea epigallocatechin-3-gallate modulates differentiation of naïve CD4⁺ T cells into specific lineage effector cells by Wang J1, Pae M, Meydani SN, Wu D.(PubMed)