#Phytochemical Indole-3-carbino Inhibits #ProstateCancer through Cell Cycle Arrests and Apoptosis, Reserachers Suggest

Kyle J. Norton

Scientists may have found a bioactive compound isolated from the cruciferous vegetable for the prevention and treatment of prostate cancer with no side effects, according to studies.

Indole-3-carbinol is a phytochemical in the class of Indoles, by the breaking down of the glucosinolate glucobrassicin, found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.

Prostate cancer is a medical and chronic condition in which the cells of the prostate have become cancerous due to the alternation of the cell's DNA.

Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during Physical (rectum) exams.

Primary prostate cancer normally starts from the cell on the surface of the inner lining of the prostate tissue and gradually spreads to the deeper part of the prostate.

At the early stage, patients may not experience any symptoms, However, at the advanced stage, prostate cancer can induce symptoms of blood in the urine, frequent urination, and urinary difficulty.

The cancer cells at this stage can also travel a distance away from the prostate to invade other healthy tissues and organs, leading to secondary metastasis tumors.

According to the statistic, the 5-year survival rate for local and regional (stage 0 and 1) stages of prostate cancer is nearly 100%.

Therefore, men who are at higher risk of prostate cancer due to family history and increase in age and inherited gene changes should have their prostate gland checked annually.

Believe it or not, more than 80% of prostate cancers are diagnosed in men who are 65 or older.

Dr. Roberto Fabiani, the lead scientist at the University of Perugia suggested that people who follow the Western diet pattern are at increased risk of prostate cancer onset.

According to the results from the review of 12 observational studies included in the meta-analysis which identified a “Healthy pattern” and a “Western pattern”, he said, "The Healthy pattern was not related to PC risk (OR = 0.96; 95% confidence interval (CI): 0.88–1.04) while the Western pattern significantly increased it (OR = 1.34; 95% CI: 1.08–1.65)".

In other words, by a change of diet from high in saturated and trans fat, red meat, and processed foods to a diet high in fruits and vegetables and whole grains, the risk of prostate cancer can be reversed.

In order to reaffirm the epidemiological evidence that suggested that intake of cruciferous vegetable intake is associated with a reduced risk of prostate cancer, researchers at the Oregon State University, Corvallis assessed the bioactive compound indole-3-carbinol against the onset of prostate cancer.

In vitro and in vivo. application of indole-3-carbinol inhibits prostate cancer by both blocking initiation and suppressing prostate cancer progression. these results were associated with the induction of phases I and II detoxification pathways.

Injection of indole-3-carbinol inhibited the cell signaling pathways associated with cancer cell proliferation and survival.

Recently, indole-3-carbinol derivatives induced cancer cytotoxicity through induction of free radical expression.

In the laboratory, I3C can induce G1 cell-cycle arrest and apoptosis in prostate cancer cells.

Furthermore, I3C and its derivative dimeric product 3,3'-diindolylmethane (DIM) inhibited the genes associated with the control of cell cycle, cell proliferation, signal transduction, and other cellular processes in prostate cancer cell lines.


Dr. Sarkar FH, the lead scientist, wrote in the final report of the experiment, "Because there is no effective treatment strategy for hormone-dependent and, most importantly, hormone-independent and metastatic prostate cancer, our strategies to sensitize prostate cancer cells to a chemotherapeutic agent by I3C and DIM is a novel breakthrough that could be used for devising novel therapies for prostate cancer".

More importantly, Wayne State University School of Medicine, in a study to confirm that a diet rich in fruits and vegetables provides phytochemicals, launched an investigation to examine the anticancer effect of indole-3-carbinol (I3C).

According to the study, I3C inhibits the growth of PC-3 prostate cancer cells
* through the Induction of G1 cell cycle arrest.

* Promoted the expression of regulators associated with cell cycle progression at G1 and S phase and proteins associated with cancer cell apoptosis.

* Inhibited proteins associated with the progression of cell cycle division

* Inhibited protein in the promotion of proteins associated with cancer cell cycle division.

Taken together, the plant base Indole-3-carbinol isolated from the cruciferous vegetable may be used for the prevention and treatment of prostate cancer with no side effects.
10,000
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

references
(1) Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention. by W Watson G1, M Beaver L, E Williams D, H Dashwood R, Ho E.(PubMed)
(2) Indole-3-carbinol and prostate cancer by Sarkar FH1, Li Y. (PubMed)
(3) Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest, and apoptosis in prostate cancer cells by Chinni SR1, Li Y, Upadhyay S, Koppolu PK, Sarkar FH.(PubMed)
(4) Indole-3-carbinol and 3',3'-diindolylmethane modulate androgen's effect on C-C chemokine ligand 2 and monocyte attraction to prostate cancer cells by Kim EK1, Kim YS, Milner JA, Wang TT. (PubMed)
(5) A Western Dietary Pattern Increases Prostate Cancer Risk: A Systematic Review and Meta-Analysis by Roberto Fabiani,1,* Liliana Minelli,2 Gaia Bertarelli,3 and Silvia Bacci. (PMC)

#Greentea EGCG Exerts a Strong Immunomodulatory Activity, Reserachers Say

Kyle J. Norton

Green tea is found to have a strong immunomodulating effect, affecting the innate and adaptive immune systems, a renowned institute study suggested.

Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including weakened immunity and painful cases of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

According to the Harvard Medical School, epigallocatechin-3-gallate (EGCG) isolated from green tea expressed a strong effect on T cell functions, including T cell activation, proliferation, differentiation, and production of cytokines.

Injection of the phytochemical in the animal model showed significant effects in regulated T cell dysfunction in the expression of autoimmune inflammatory diseases as well as ameliorated T cell-mediated autoimmune diseases.

Furthermore, in naïve CD4(+) T cells proliferate and differentiate into different effector subsets, green tea EGCG inhibited the pro-inflammatory Th1 and Th17 cells, subsets of Th cells responsible for inducing autoimmunity, thus improving symptoms and reducing the pathology of autoimmune diseases.

Additionally, Dr. Wu D, the lead author said, "(The) protective effect EGCG is associated with the suppressed proliferation of autoreactive T cells, in reduced production of pro-inflammatory cytokines of Th1 and Th17, and increased T cell regulation populations in lymphoid tissues and central nervous system".

Further evaluation of green tea EGCG effect in regulated CD4(+) T helper (Th) subsets Th1, Th9, and Th17 cells conducted by the Tufts University, postulated that the phytochemical impeded Th1, Th9, and Th17 differentiation in exhibited inflammation by prevented IL-6(the pro-inflammatory cytokine)-induced suppression of Treg development.

More importantly, in experimental autoimmune encephalomyelitis (EAE) rats, EGCG improved function of CD4(+) T cellsthe  through modulated the expression of IL-6 induced cytokine(gp130) in response to autoimmune function and cellular response.

Taken together, the green tea process has a strong immunomodulating effect in reduced risk and treatment of autoinflammatory and immune disease, but long-term and large amounts of intake should be taken with care to prevent toxicity.


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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published on line, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Immunomodulating effects of epigallocatechin-3-gallate from green tea: mechanisms and applications by Pae M1, Wu D.(PubMed)
(2) Green tea EGCG, T cells, and T cell-mediated autoimmune diseases by Wu D1, Wang J, Pae M, Meydani SN.(PubMed)
(3) Green tea epigallocatechin-3-gallate modulates differentiation of naïve CD4⁺ T cells into specific lineage effector cells by Wang J1, Pae M, Meydani SN, Wu D.(PubMed)

#Bromelain Processes Anti-Chronic Rhinosinusitis Property, According to Studies

Kyle J. Norton

Rhinosinusitis (RS) is a condition associated with the inflammation of the sinuses and nasal cavity.
Sinusitis is an inflammation of the paranasal sinuses that causes a headache as a result of exposure to a cold or flu virus, or an allergic reaction to pollen, mold, dust, or smoke.

Sinusitis affects 37 million people each year.

Other symptoms of RS include nasal congestion or obstruction, facial or dental pain, purulent rhinorrhea, postnasal drainage, headache, and cough.

Some patients may also experience symptoms of fever, fatigue, hyposmia, ear fullness or pressure, voice changes, epiphora, fever, and psychological effects, and fatigue.

If you have some of the above symptoms that last more than 12 weeks, you may have chronic rhinosinusitis,

If you experience some of the aforementioned symptoms without a cold or flu, you may have rhinosinusitis. Conventionally, most cases of bacterial rhinosinusitis (BRS) are treated by antibiotics.


In viral rhinosinusitis (VRS), medication focuses on reducing symptoms and improving quality of life.

Out of many risk factors involved in the onset of the condition, some researchers suggested that people with an immune deficiency may be vulnerable to rhinosinusitis developing.


Dr. Sergio E. Chiarella, the lead scientist wrote, "CRS is a common disease; in those patients with frequent exacerbations or who are refractory to treatment, an immunodeficiency evaluation should be considered. Treatment includes vaccination, antibiotic therapy, immunoglobulin replacement, and surgery".

More precisely, people who are using immune suppressants or weakened and immature immune systems are at an increased risk of rhinosinusitis.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural compound for the treatment of an inflammatory condition associated with the sinuses and nasal cavity, researchers examined the bromelain effects on patients with chronic rhinosinusitis (CRS).

40 patients including 20 patients were given bromelain 500 mg tablet twice daily for 30 days, and 20 controls enrolled in the study.

According to the observation in the turbinate and ethmoid mucosas and in the serum of both groups, bromelain showed significant anti-inflammatory activity in paranasal sinus pathologies.

In other words, the efficacy of bromelain anti-chronic rhinosinusitis was attributed to its function in distribution evenly in the sinuses and nasal cavity.

Taken altogether, bromelain may be considered supplement for the prevention and treatment of chronic rhinosinusitis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain's penetration into the blood and sinonasal mucosa in patients with chronic rhinosinusitis by Passali D1, Passali GC2, Bellussi LM1, Sarafoleanu C3, Loglisci M1, Manea C3, Iosif C4, Passali FM. (PubMed)
(2) Alternative therapies for chronic rhinosinusitis: A review by Griffin AS1, Cabot P, Wallwork B, Panizza B. (PubMed)
(3) Immune deficiency in chronic rhinosinusitis: screening and treatment by Sergio E. Chiarella and Leslie C. Grammer. (PMC)

#PhyticAcid Inhibits Proteins Associated with the Onset of #ProstateCancer, Scientists Suggest

Kyle J. Norton

Phytochemicals phytic acid may be the next-generation natural ingredient for the prevention and treatment of prostate cancer, some scientists found.

Cancer is a class of diseases in which a group of cells grow and multiply disordered and uncontrollable way in our body.cells

As cancer continues proliferation, at certain stages it can damage other healthy tissues. Sometimes cancer cells can spread to other organs in the body via lymph or blood.

Prostate cancer is a medical condition caused by the alternation of the cell on the surface of the inner lining of the prostate tissue.

Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during physical (rectum) exams.

According to the statistic, approximately, 1 man in 9 will be diagnosed with prostate cancer during his lifetime and 6 cases in 10 are diagnosed in men aged 65 or older.

Prostate cancer shares common symptoms of an enlarged prostate, including frequent urination particularly at night, weak or interrupted urine flow, and erectile dysfunction.


Symptoms that are not found in enlarged prostate include blood in the urine and blood in the seminal fluid.

If you are experiencing some of the above symptoms, please check with your doctor to rule out the possibility of prostate cancer

The causes of prostate cancer are unknown. The increases with age, especially after age 50. family history. ethnicity, hereditary breast, and ovarian cancer (HBOC) syndrome, and genetic proposition are some risks actors associated with the onset of the disease.

Some researchers suggested that a poor diet is one of the major risk factors found in patients with the disease.

Dr. Amir Bagher, the lead scientist evaluated the dietary patterns and risk of prostate cancer and wrote, "After adjustment for potential confounders, a healthy dietary pattern was associated with decreased risk of prostate cancer (highest versus lowest tertile OR:0.24; 95% CI: 0.07-0.81; trend p: 0.025). An unhealthy dietary pattern was related to increased risk of prostate cancer(highest versus lowest tertile OR:3.4; 95% CI: 1.09-10.32; trend p: 0.037)".

And, "an unhealthy dietary pattern was associated with an increased risk of prostate cancer. However, a healthy dietary pattern was associated with a decreased risk of prostate cancer".


The results strongly suggested that by following a healthy diet pattern, one can substantially reduce the risk of prostate cancer.

Phytic acid (Inositol hexaphosphate) are phytochemical of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.

In finding a natural ingredient for the treatment of prostate cancer with no side effects, researchers assessed the effects of phytic acid (inositol hexakisphosphate (IP6)) on the activation of phosphoinositide 3-kinase (PI3K)-Akt pathway in promoting survival, proliferation, and angiogenesis in human prostate cancer cells.

In invasive human prostate cancer, PC-3 and C4-2B cells, IP6 treatment of cells suppressed proliferation, and induced apoptosis through protein associated with the apoptotic and cell death programming pathways.

Phytic acid also inhibited cancer cells through proteins associated with cancer cell growth, proliferation, differentiation, motility.

Furthermore, IP6 inhibited transcription and cell migration. through cell cycle arrest at the G1 phase.


Dr. Gu M, the lead scientist, after taking into account co and confounders said, " IP6 suppresses cell survival, proliferation, and angiogenesis but induces death in prostate cancer cells, which might have translational potential in preventing and controlling the growth of advanced and aggressive prostate cancer for which conventional chemotherapy is not effective".

In advanced and androgen-independent human PCa PC-3, Treatment of PC-3 cells with 2 mM IP6 strongly inhibited both growth and proliferation and decreased cell viability; similar effects were also observed in other human PCa DU145 and LNCaP cells.

IP6 also caused a strong apoptotic death of PC-3 cells through proteins associated with the activation of cell death programming and induced apoptosis.

The inhibition of the PC-3 cancer cell line by IP6 also is associated with the inhibition of the protein-involved cells proliferation, and differentiation, similar to that of the above study.

Interestingly, researchers also discovered that IP6 also inhibited the transcription factor activity in promoting cancer cell growth and reproduction, and regeneration

Where a transcription factor (TF) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA.

Taken al\\together, phytochemicals phytic acid may be considered a bioactive compound for the prevention and combined with the primary therapy for the treatment of prostate cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as a potential target by Gu M, Roy S, Raina K, Agarwal C, Agarwal R.(PubMed)
(2) Inositol hexaphosphate downregulates both constitutive and ligand-induced mitogenic and cell survival signaling, and causes caspase-mediated apoptotic death of human prostate carcinoma PC-3 cells. by Gu M, Raina K, Agarwal C, Agarwal R.(PubMed)
(3) Dietary patterns and risk of prostate cancer: a factor analysis study in a sample of Iranian men by Amir Bagheri, Seyed Mostafa Nachvak, Mansour Rezaei, 3 Mozhgan Moravridzade, Mahmoudreza Moradi, 4 and Michael Nelson. (PMC)

#Honey Used Alone Or Combined with Conventional Medicines Process a Strong Anti-Influenza Virus Activity, Researchers Show

Kyle J. Norton

Scientists may have found a natural alternative for the treatment of Influenza, according to studies. Influenza, also known as the flu, is an infectious disease caused by an influenza virus.

The most common symptoms include high fever, runny nose, sore throat, muscle pains, headache, coughing, and sneezing. A healthy individual may recover from influenza without medication in a few days with the symptoms that may last for a week.

However, people with a weakened immune system may have a problem to recover themselves without the assistance of medication. In severe cases, influenza can induce complications of pneumonia, ear, and sinus infection, and death.

People with medical conditions such as heart, lung, kidney, liver disease, AIDs, and severe anemia are at a higher risk of the onset of influenza, particularly in the elderly with a weakened immune system.

Children and adolescents who are receiving long-term aspirin therapy are at risk of being infected by the virus.

Furthermore, some researchers suggested that obese individuals also are more likely to be infected by influenza, compared to non-obese individuals.

Dr. J Justin Milner, the lead scientist in examining the obesity and influenza infection severity said, "Obesity also increases susceptibility to bacterial and viral infections [2]. In 2009, the CDC identified obesity as a risk factor for hospitalization and death from pandemic H1N1 influenza virus infection".

And, "An association between obesity and severe influenza outcomes, including seasonal influenza, has since been corroborated in other epidemiological studies".


The finding strongly indicated the risk of influenza in obesity.

Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.

With an aim to find a natural whole food for the treatment of influenza, researchers examined the anti-influenza viral activity of honey from various sources.

Antiviral activities of honey samples were evaluated in MDCK cells. Injection of Manuka honey efficiently inhibited influenza virus replication (IC50 5 3.6 1.2 mg/mL; CC50 5 82.3 2.2 mg/mL; selective index 5 22.9).

Furthermore,. In the presence of 3.13 mg/mL manuka honey, the IC50 of zanamivir or oseltamivir was reduced to nearly 1/1000th of their single use.

The finding clearly suggested that Manuka honey processes a strong anti-influenza activity when used alone or by promoting the function of conventional medicine when used combinational.

Some researchers suggested that manuka also inhibited the symptoms of influenza such as blocked sinuses, sore throat and coughs through its major compound Methylglyoxal (MGO).


Moreover, Manuka honey also inhibited the production of proinflammatory cytokines during the acute phase of influenza, thus providing instant relief fa or a sore throat and cough.


In the immune perspective, Manuka honey also increased the expression of serum immunoglobulin G (IgG) which plays a critical role against the onset of infection by microorganisms.

Dr. Ogi M, the lead scientist after taking into account co and confounders said, "The relative risk for bacterial infection among patients with serum immunoglobulin G (IgG) levels below 600 mg/dL was 6.74 compared with that for patients with serum IgG levels over 600 mg/dL (95% confidence interval, 1.22 to 36.32; P = 0.029)"

And "In patients with serum creatinine levels over 2.0 mg/dL, the relative risk of bacterial infection was 5.31 compared with patients with serum creatinine levels below 2.0 mg/dL (95% confidence interval, 1.08 to 26.09; P = 0.040)".

The finding also suggested that Manuka honey also can modulate immune expression to prevent the infection caused by the influenza virus by increased production of immunoglobulin G.

Taken together, there is no doubt that Manuka honey can be considered a functional remedy for the prevention and treatment of influenza, pending the confirmation of a large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Anti-influenza viral effects of honey in vitro: the potent high activity of manuka honey by Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N. (EL SEVIER)
(2) Manuka Honey the best Natural Cold and Flu Remedy By Mr. Vitamins
(3) Risk factors for infection and immunoglobulin replacement therapy in adult nephrotic syndrome by Ogi M1, Yokoyama H, Tomosugi N, Hisada Y, Ohta S, Takaeda M, Wada T, Naito T, Ikeda K, Goshima S. (PubMed)
(4) Obesity and influenza infection severity by J Justin Milner & Melinda A Beck. (Future Medicine)

#Alliin Works Synergistically with Other Antioxidants to Promote Anti-Angiogenesis and Anti Cancer Activity, Researchers Show

Kyle J. Norton

Angiogenesis is the process that promotes the formation of new blood vessels involving many factors including the migration, growth, and differentiation of endothelial cells.

Believe it or not, all active tissues in the body are at a distance less than a hundred micrometers from a blood capillary formed by the process of angiogenesis.

Angiogenesis is important for the cells for the diffusion exchange of nutrients and metabolites through the small blood vessels.

In normal and healthy conditions, stimulating angiogenesis has been found to have a therapeutic effect for the treatment of ischemic heart disease, peripheral arterial disease, and wound healing.


However, in cancers, stimulating angiogenesis in tumor cells has been associated with tumor proliferation and metastasis.

In other words, the angiogenesis process a function of a double sword, on one hand, the process provides an ideal condition for diseases and wound healing. On the other hand, it promotes invasive and overgrowth tumors.

Genentech in the article "Tumor Angiogenesis and the VEGF Pathway" wrote, "Angiogenesis is a necessary part of the process in the progression of cancer from small, localized neoplasms to larger, growing, and potentially metastatic tumors. To grow beyond 1 to 2 mm in diameter, a tumor needs an independent blood supply, which is acquired by the expression of growth factors that recruit new vasculature from existing blood vessels".

"This process continues even as the tumor matures. Thus, the upregulation of angiogenesis is a key step in sustained tumor growth and may also be critical for tumor metastasis".

In other words, by inhibiting the process of blood vessel formation of the tumor, cancer may be curable.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

In the urgency to find a potential ingredient for the treatment of cancer with no side effect, scientists examined the phytochemical alliin, a compound derived from garlic anti-angiogenesis activity.

In the chick chorioallantoic membrane, the injection of alliin exerted a significant effect on the inhibition of fibroblast growth factor-2 (FGF2) associated with the angiogenesis.

In the CAM model, alliin also inhibited the vascular endothelial growth factor (VEGF)-induced angiogenesis.
Combined with antioxidant vitamins C and E significantly (P < 0.001) enhanced the function of alliin inhibitory efficacy on FGF2-induced EC tube formation and angiogenesis, particularly in the colon and fibrosarcoma tumor growth.

More precisely, alliin significantly inhibited both FGF2 and VEGF secretion from human fibrosarcoma cells compared to other types of tumors in a concentration-dependent manner

However, the anti-angiogenesis of alliin was reversed if the NO synthesis inhibitor nitro-L-arginine methyl ester (L-NAME) was injected.


The efficacy of alliin was attributed to the activation of the expression of a protein involved in immune tumor suppression.

In other words, alliin worked synergistically with other antioxidants to promote anti-angiogenesis and anticancer efficacy.

Dr. Mousa AS, the lead scientist wrote, "These data also suggest the implication of cellular NO and p53 as mediators of anti-angiogenesis and anticancer effects of alliin".

Taken together, alliin may be considered a supplement for the inhibition of angiogenesis in the promotion of tumor growth, pending the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-angiogenesis efficacy of the garlic ingredient alliin and antioxidants: role of nitric oxide and p53 by Mousa AS1, Mousa SA. (PubMed)
(2) Tumor Angiogenesis and the VEGF Pathway by The Genentech

3,3'-Diindolylmethane Exhibits Cytotocxicity and Apoptosis Againast #LiverCancer Cells, Researchers Find

Kyle J. Norton

Scientists may have found a bioactive ingredient for the treatment of liver cancer with no side effects, according to studies.
The liver is the largest internal organ in the human body which plays a critical role in maintaining the integrity of cell walls, the production of vitamin D and steroid hormones, and aiding the digestive system in the absorption of nutrients, through the production of cholesterol.

Additionally, the liver also filters out waste from the blood coming from the digestive system before passing it to the other parts of the body.

Liver cancer is a medical condition caused by irregular cell growth in the tissues of the liver.

Most cases of liver cancer start in the cells on the surface of the inner lining of the liver tissues before penetrating into deeper layers of the liver.

At the early stage due to the small size of the tumor and lack of nerve tissues, most patients are asymptomatic.

However, at the advanced stage, cancer cells can travel a distance away from the liver to infect other healthy tissues and organs, leading to secondary metastasis.

Patients at this stage may experience the general symptoms of cancers such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue accompanied by the symptoms of persistent upper abdominal pain, abdominal swelling, jaundice, and chalky stools.

If you have some of the aforementioned symptoms, please make sure you check with your doctor to rule out the possibility of liver cancer.

Out of many risk factors associated with the onset of liver cancer, some researchers suggested that people who carry hepatitis viral may have a substantially higher risk of the disease.

Dr. Marc Ringehan, the lead researcher said, "Hepatitis B and C viruses are a global health problem causing acute and chronic infections that can lead to liver cirrhosis and hepatocellular carcinoma (HCC). These infections are the leading cause of HCC worldwide and are associated with significant mortality, accounting for more than 1.3 million deaths per year".

And, "The majority of viral-associated HCC cases develop in subjects with liver cirrhosis; however, hepatitis B virus infection can promote HCC development without prior end-stage liver disease".

Scientists in seeking potential and bioactive compounds for the treatment of liver cancer examined 3'3-Diindolylmethane (DIM, the major product of the acid-catalyzed oligomerization of indole-3-carbinol anti-liver cancer properties.

In two HCC cell lines SMMC-7721 and MHCC-97H, injection of DIM inhibited the proliferation, migration, and invasion of cancer cells.

In nude mice, DIM significantly decreased the volumes of SMMC-7721 orthotopic liver tumors and suppressed lung metastasis.

Furthermore, DIM decreased the level of phospho-FAK (Tyr397) which is found elevated in both vitro and in vivo.


The DIM anti-cancer cells' efficacy on proliferation, migration, and invasion is probably due to the inhibition of the expression of matrixes (MMP2-9) associated with the promotion of cancer cell growth and invasion.

Dr. Li WX, the lead scientist wrote, "These results demonstrated that DIM blocks HCC cell metastasis by suppressing tumor cell migration and invasion".

Moreover, in order to reveal more information about DIM anti-liver cancer activity, researchers investigated whether diindolylmethane affects HA59T cells.

At concentrations of 10-75 μM, diindolylmethane killed cells in a concentration-dependent manner, particularly, in diindolylmethane (25-50 μM) induced apoptosis in a concentration-dependent manner.
The cytotoxic effect of diindolylmethane against the tested liver cancer cell line was not reversed by chelating cytosolic Ca(2+)


Where Calcium (Ca2+) ions are important for cellular signaling. Its flow plays an essential role in regulating several secondary messenger systems in neural adaptation for the visual, auditory, and olfactory systems.


The results suggested that DIM inhibited the onset and progression of liver cancer through a number of mechanisms, including proteins involved in anti-cell proliferation and migration, and the promotion of apoptosis.

Taken together, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of liver cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3'3-Diindolylmethane inhibits migration, invasion, and metastasis of hepatocellular carcinoma by suppressing FAK signaling by Li WX1, Chen LP2, Sun MY1, Li JT1, Liu HZ1, Zhu W. (PubMed)
(2) Effect of diindolylmethane on Ca(2+) movement and viability in HA59T human hepatoma cells by Cheng JS1, Shu SS, Kuo CC, Chou CT, Tsai WL, Fang YC, Kuo LN, Yeh JH, Chen WC, Chien JM, Lu T, Pan CC, Cheng HH, Chai KL, Jan CR. (PubMed)
(3) Viral hepatitis and liver cancer by Marc Ringehan,1,2,3 Jane A. McKeating,4,5 and Ulrike Protzer. (PMC)