#Herbal #Ginger Inhibits the Onset of #Gastric/Stomach Ulcers Induced by Aspirin, According to Studies

Kyle J. Norton

Gastric ulcers or stomach ulcers are conditions characterized by painful sores in the stomach lining. Unlike the gastric ulcers, peptic ulcers are sores found in the stomach and small intestines.

The exact causes of gastric ulcers are not clearly identified. However, according to epidemiological studies, a bacterial infection caused by H. pylori infection has been found in the range of 30 to 50% of people with stomach ulcers.
Gastric ulcers caused by H. pylori infection are more likely to develop in patients over 40 in the US

Other risk factors associated with gastric ulcers include long-term use of certain medications, such as NSAID which has been found to cause more than 50% of peptic ulcers and stress.

Treatment of gastric ulcers is depended totally on the underlying causes, including antacids for the reduced acid in the stomach, and antibiotics for the elimination of Helicobacter pylori.

Unfortunately, people with gastric ulcers infected by Helicobacter pylori treated with antibiotics have a higher risk of recurrence. In severe cases, surgery may be necessary.

Untreated or uncovered stomach ulcers may induce some complications, including stomach bleeding penetration, and cancer.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a potential ingredient for the treatment of gastric ulcers with no side effects, researchers examined the possible mechanism of the protective effect of ginger on aspirin-induced gastric ulcers.

The study included 40 adult male albino rats randomized and divided into four groups (10 animals per each group) and orally received the following once daily for 5 days:

Group I: 3 ml of 1% carboxymethyl cellulose;

Group II: ginger powder (200 mg/kg body weight) suspended in 3 mL of 1% carboxymethylcellulose;

Group III: aspirin (400 mg/kg body weight) suspended in 3 ml of 1% carboxymethylcellulose in water.

Group IV: ginger and 30 minutes later, received aspirin suspended in 1% carboxymethylcellulose, in similar doses as received in groups II and III.

Before the treatment of ginger, aspirin-induced a significant increase in the macroscopic ulcer score, and gastric damage was observed by the shed and disrupted epithelium, mucosal hemorrhage, submucosal edema and leukocyte infiltration, loss of the mucus of the mucosal surface.

Furthermore, in the protein's perspective, Aspirin significantly increased the expression of apoptosis regulator Bax, inducible nitric oxide synthase (iNOS) associated with the production of proinflammatory cytokines and heat shock protein 70 (HSP70) involved stress response.


Injection of ginger protected the gastric integrity by restoring all damage caused by aspirin in the induction of gastric ulcer.

Dr. Salah Khalil M, said, "Ginger ameliorated the histological changes by reducing Bax and iNOS and increasing HSP70 expressions".

In other words, the overexpression of proteins associated with the onset of gastric ulcer also was significantly reduced by ginger administration.

Taken together, ginger may be considered a functional alternative for the treatment of gastric ulcers, pending the confirmation of a large sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) The postulated mechanism of the protective effect of ginger on the aspirin induced gastric ulcer: Histological and immunohistochemical studies by Salah Khalil M. (PubMed)
(2) Synbiotic (probiotic and ginger extract) loaded floating beads: a novel therapeutic option in an experimental paradigm of gastric ulcer by Singh PK1, Kaur IP. (PubMed)

Gelam and Acacia Honey Process Anti-Obesity Property with Inducing Liver Toxicity, Researchers Find

Kyle J. Norton

In seeking natural therapy with no side effects, scientists may have found a bee-based product for the treatment of obesity, according to studies.
Compared to an ideal weight, that reduces the risk of cardiovascular disease, body weight greater than 20 percent is considered obese.

Obesity is a medical condition caused by excess body fat that has accumulated over time, while overweight is a condition of excess body weight relative to height.

According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity.

Epidemiological studies in the investigation of the complications of obesity found that cardiovascular problems such as high blood pressure, heart disease, accelerated atherosclerosis, stroke... and chronic lower back pain are the most common disease complications associated with obesity.

According to data from the National Health and Nutrition Examination Survey (NHANES), 2013–2014, more than 1 in 3 and 13 adults in the US were considered to have obesity and extreme obesity, respectively.

Although there are many risk factors involved the onset of the disease, some researchers suggest an unhealthy lifestyle is one of the major causes of obesity in the Western world.

Dr. Robert F. Kushner, in the examination of the unhealthy lifestyle risk of obesity of the 53‐item lifestyle pattern questionnaire posted on a commercial weight loss program Web site collected from 2004 through 2008, wrote, "Unhealthy lifestyle patterns in diet, exercise, and coping were highly prevalent among this population".

The results findings clearly suggested a strong correlation between diet, exercise, and obesity.

Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.

The liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.

In the urgency to find a natural remedy for the treatment of widespread obesity in the Western world, researchers evaluated the potential of honey consumption in controlling obesity.


The study compared the two local Malaysian honey types: Gelam and Acacia honey activities in reducing excess weight gain and other parameters related to obesity.

Male Sprague-Dawley rats selected for the study were induced obese by a high-fat diet (HFD) prior to introduction with/without honey or orlistat for four weeks.

Rats fed with Gelam honey showed significant reductions in excess weight gain and adiposity index compared to HFD rats.

Furthermore, parameters related to obesity such as levels of plasma glucose, triglycerides, and cholesterol, plasma leptin and resistin, liver enzymes, renal function, and relative organ weight in Gelam and Acacia honey-treated groups were reduced significantly, compared to obese rats.

Compared to the treatment of orlistat, Gelam, and Acacia honey showed similar results without inducing hepatotoxicity effects.

Hepatotoxicity is a known side effect of orlistat.

Where Orlistat is a drug used for the treatment of obesity, sold over-the-counter as Alli by GlaxoSmithKline in the United Kingdom and the United States.

Dr. Samat S, the lead scientists wrote in the final report, "consumption of honey can be used to control obesity by regulating lipid metabolism and appears to be more effective than orlistat".

Taken altogether, hiney, particularly Gelam and Acacia honey may be considered anti-obesity functional remedies with no side effects, pending to the confirmation of larger sample size and multicenter human study.


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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)

Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Four-Week Consumption of Malaysian Honey Reduces Excess Weight Gain and Improves Obesity-Related Parameters in High Fat Diet Induced Obese Rats by Samat S1, Kanyan Enchang F1, Nor Hussein F2, Wan Ismail WI. (PubMed)

#Coffee Inhibits Clusters Associated with an Increased Risk of #MetabolicSyndrome, According to Studies

Kyle J. Norton

In comparison to herbal medicine, food therapy even takes longer to ease symptoms, depending on the stages of the treatment that directly address the cause of the disease.
Metabolic Syndrome is a group of risk factors associated with the development of cardiovascular disease and type 2 diabetes, including high blood pressure, abnormally high blood cholesterol, and triglyceride levels,.....

A joint study by respectable institutes suggested that intake of coffee and coffee caffeine daily and regularly may be associated with an attenuated risk of metabolic syndrome.

Coffee, second to green tea, is a popular and social beverage all over the world, particularlybeans in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

According to the searching of the database from f PubMed and the China National Knowledge Infrastructure (CNKI) for relevant articles published between 1 January 1999 and 31 May 2015, including 11 published reports and 13 studies with a total of 159,805 participants were eligible for our meta-analysis, the relative odd risk ratio of metabolic syndrome between the highest vs lowest category of coffee consumption was 0.872

The review also observed a non-linear relationship between coffee and coffee caffeine consumption in ameliorated risk of metabolic syndrome, by dose-response analysis.

Additionally, in a cross-sectional population-based survey of 8,821 adults (51.4% female) conducted in Krakow, Poland. to evaluate the coffee and tea consumption and risk of metabolic syndrome, using food frequency questionnaires, observation of the questionnaire returned from participants expressed an interesting association between high coffee consumption of 3 cups and the clusters of lower BMI, waist circumference, systolic and diastolic blood pressure, triglycerides, and higher HDL cholesterol than those drinking less than 1 cup/day.

The study apparently indicated that people drinking 3 cups of coffee daily and regularly have a favorably ameliorated risk of metabolic syndrome even after adjusting for potential confounding factors.

More importantly, the study also pointed out that high coffee consumption was negatively associated with waist circumference, hypertension, and triglycerides in women but not in men.

Furthermore, in the animal evaluation of the effect of coffee drinking on clinical markers of diabetes and metabolic syndrome in Zucker rats including Diabetic Zucker rats with metabolic syndrome and control Zucker rats, researchers at the Fluminense Federal Institute postulated that after animals received daily doses of coffee drink by gavage for 30 days, coffee consumption expressed a decreased risk of metabolic syndrome in reduced serum glucose, total cholesterol and triglycerides in compared to non treatment group.

Dr. Abrahão SA, the lead researcher said, "The results demonstrate that treatment with roasted coffee drink, because of its hypoglycemic and hypolipidemic effect, is efficient in the protection of animals with metabolic syndrome and diabetes mellitus type 2".

The findings from the above studies suggested that coffee and coffee caffeine drinking daily and regularly have a favorably profound effect in decreasing the risk of metabolic syndrome, particularly in women.


Ovarian Cysts And PCOS Elimination
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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Coffee consumption and risk of the metabolic syndrome: A meta-analysis by Shang F1, Li X1, Jiang X2.(PubMed)
(2) Association of daily coffee and tea consumption and metabolic syndrome: results from the Polish arm of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Topor-Mądry R3, Pikhart H4, Szafraniec K3, Pająk A3.(PubMed)

#Greentea inhibits the Genes and Pathways Associated with an Increased Symptoms Severity of #Osteoarthritis, Researchers Say

Kyle J. Norton

Osteoarthritis (OA), a form of arthritis, is a condition characterized by aging progression of wear and tear on a joint, affecting over 25 million people in the United States alone.

In a randomized open-label active-controlled clinical trial of 50 adults with osteoarthritis of the knee allocated to receive the green tea extract (in dosage form of the tablet) plus diclofenac tablet as "intervention group"; or: diclofenac tablet alone as "control group" for a period of four weeks, combination-treated group exerted a significant improvement of physical function in compared to control.

The treatment group also expressed similar progress in pain reduction during knee joint physical function in adults with osteoarthritis as in the control group.

Additionally, in comparing the effect of curcuminoid extract, hydrolyzed collagen, and green tea extract, in chondrocytes culture cells, researchers found that a combination of all components score an enormous expression of reduced production of pro-inflammatory cytokines through various mechanisms, including ameliorated free radical elucidation.

Furthermore, in support of the above differentiation, the study in the investigation of posttraumatic osteoarthritis (OA) mouse model tested with EGCG against the progression of OA and relieve OA-associated pain, suggested that EGCG-treated mice promoted cartilage production against Safranin O, staining of the knee joint cartilage loss and cartilage erosion in compared to control group with no treatment.

Importantly, the cartilage of treated mice also displays a significant reduction of the gene in regulated degeneration of connective tissue as well as pathways involved promotional of tissue inflammation.

Additionally, the pain score of treated mice also exhibited a significant enhancement, compared to a control group.

Taken together, there is no doubt that the green tea process a therapeutic and integrated form for the prevention and treatment of symptoms of pain as well as improved physical activity of OA patients through protection against cartilage degeneration.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Sources
(1)Green tea (Camellia sinensis) for patients with knee osteoarthritis: A randomized open-label active-controlled clinical trial by Hashempur MH1, Sadrneshin S2, Mosavat SH3, Ashraf A4.(PubMed)
(2) Curcuminoids extract, hydrolyzed collagen and green tea extract synergically inhibit inflammatory and catabolic mediator's synthesis by normal bovine and osteoarthritic human chondrocytes in monolayer by Comblain F1, Sanchez C1, Lesponne I2, Balligand M3, Serisier S2, Henrotin Y4.(PubMed)
(3) Green tea polyphenol treatment is chondroprotective, anti-inflammatory, and palliative in a mouse post-traumatic osteoarthritis model by Leong DJ, Choudhury M, Hanstein R, Hirsh DM, Kim SJ, Majeska RJ, Schaffler MB, Hardin JA, Spray DC, Goldring MB, Cobelli NJ, Sun HB.(PubMed)

#Ginger Exerts Gastroprotective Effects through Its Antioxidant Activity, According to Studies

Kyle J. Norton

Ginger may have a significant effect on the prevention and treatment of gastrointestinal disorders, some scientists suggested.
Gastrointestinal disorders are medical conditions, involving the esophagus, stomach, small intestine, large intestine, and rectum.

Most common gastrointestinal disorders are very mildly associated with digestive discomforts that can be resolved in a few days.

The gastroprotective effect is an action that protects the gastrointestinal tract against the onset of any disease, including infection and inflammation.

The causes of digestive disorders can be multiple. Most gastrointestinal disorders are caused directly by the disorders of the digestive system such as poor diet patterns. However, long-term use of certain medications can also induce gastrointestinal disorders, including Manticholinergic medication, non-steroidal anti-inflammatory drugs, and antibiotics.

In the search for a diet therapy that can reverse and protect the digestive system against gastrointestinal disorders, researchers at the University of Florida, wrote, "Diet therapy through the elimination of offending foods such as wheat gluten or lactose, or inclusion of specialized products such as medium-chain triglycerides or elemental formulas, can sustain nutritional status".

And "Dietary components such as insoluble fiber appear to have physiologic effects, while soluble fibers may have metabolic effects important to diabetes and cardiovascular disease".


Additionally, in the differentiation of types of diet may have a direct contribution to reducing the risk of gastrointestinal disorders, the authors continued, "Avoiding offending foods by Crohn's patients is an acceptable practice as long as entire categories of foods are not deleted. Avoiding all foods containing gluten from wheat, rye, barley, and oats, however, is a crucial prerequisite to recovery from celiac disease. Gluten is commonly used as a stabilizer, emulsifier, and extender in the food industry and is not always shown on food labels. Careful consultation with a registered dietitian can identify hidden sources of gluten in the diet.".

These results clearly indicated, that depending on the types of gastrointestinal disorders, diet therapy with modification could have a strong impact on the prevention of the onset of the disease.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a natural whole food that processes gastrointestinal protective effects, researchers looked into rhizomes of Zingiber officinale Roscoe (Zingiberaceae), commonly known as ginger, an important kitchen spice, possessing myriad health benefits.

In laboratory animals., ginger was shown to be effective in preventing gastric ulcers induced by nonsteroidal anti-inflammatory drugs [NSAIDs like indomethacin, aspirin], reserpine, ethanol, and acetic acid and Helicobacter pylori-induced gastric ulcerations.

The gastroprotective efficacy of ginger was attributed to its free radical scavenging, antioxidant; inhibition of lipid peroxidation activities.


Furthermore, in the evaluation of the gastroprotective effect to examine the turmeric (Curcuma longa) and ginger (Zingiber officianale), researchers conducted a study in the ethanol-induced ulcers animal model.

Selected rats were given 100, 500, and 1000 mg/kg body weight orally.


Application of TEO and GEO inhibited ulcers caused by the injection of ethanol by 84.7% and 85.1%, respectively, as seen from the ulcer index.

The reduced antioxidant enzymes such as GPx, SOD, catalase, and GSH produced by alcohol administration were significantly (p<0.001) increased by the simultaneous administration of TEO and GEO.

Ethanol-induced lesions such as necrosis, erosion, and hemorrhage of the stomach wall were significantly reduced after the oral administration of essential oils.


These results strongly suggested turmeric and ginger exerted a significant gastroprotective effect against gastrointestinal lesions with no side effects.

Taken together, ginger may be considered functional for the prevention and combined with primary medicine for the treatment of gastrointestinal disorders,

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe) by Haniadka R1, Saldanha E, Sunita V, Palatty PL, Fayad R, Baliga MS. (PubMed)
(2) Gastroprotective activity of essential oils from turmeric and ginger by Liju VB, Jeena K, Kuttan R. (PubMed)
(3) Ginger extract and polaprezinc exert gastroprotective actions by anti-oxidant and growth factor modulating effects in rats by Ko JK1, Leung CC. (PubMed)
(4) Dietary therapy in gastrointestinal disease by Anderson CR1, Cerda JJ. (PubMed)

#GreenTea #EGCG, EGC, GTE, and BTE Reduce Symptoms and Complications of Rheumatoid Arthritis RA throguh theirs Anti-Inflammatory Activity, According to Studies

Kyle J.Norton


Green tea exhibited anti-inflammatory effects in reduced symptoms and progression of
Rheumatoid Arthritis, a renowned institute study suggested

Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints tissues, and organs in the body after the age of 40 and causing the diminished quality of life of many elders.

Green tea, a precious drink processes an umber of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including dizziness, low energy, weakened immunity, and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

According to the joint study led by Washington State University College of Pharmacy, green tea (EGCG, EGC, and EC) was shown to ameliorate the expression of pro-inflammatory mediators including (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs), through the effects of its phytochemical compounds of EGCG and EGC antioxidant activities.

Dr. Fechtner S, the lead researcher said," EGCG is the most effective catechin at inhibiting downstream inflammatory signaling, its effectiveness could be hindered by the presence of (epicatechin) EC".

In the investigation of the anti-inflammatory activity of green versus black tea aqueous extract in a rat model with orally/daily distilled water as the placebo, indomethacin (1.0 mg/kg body weight; a non-steroidal/anti-inflammatory drug), or tea aqueous extracts (for 28 or 14 consecutive days administrated from day 0 or 14 of arthritis induction, respectively), group treated with a high dose of GTE (from day 0) significantly alleviated (P < 0.05-0.001) the progression and all complications induced by rheumatoid arthritis in compared placebo.

More importantly, Researchers also found that the expression of the anti-arthritic activity of the high dose of GTE (from day 0) mediated by significantly decreasing the systemic production of pro-inflammatory cytokines and the expression of chemokine receptor-5, a protein in activated immune activities in the in synovial tissues, was comparable (P > 0.05) with that of indomethacin (12.9-53.8 vs. 9.5-48.4%, respectively).

Furthermore, the anti-arthritic potency of tea aqueous extracts was dosed dependent on the order of a high dose of GTE > low dose of GTE ≥ high dose of BTE > low dose of BTE.

Another study suggested that green tea extract reduced symptoms and risk of complications probably are the result in regulating chemokine(a family of cytokines secreted by cells) production in an immune reaction and chemokine receptor expression in interaction with proinflammatory cytokines of human RA synovial fibroblasts in rat adjuvant-induced arthritis (AIA).


Taking together, green tea may be served as a functional food to reduce symptoms and risk of complications for patients with rheumatoid arthritis.


Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Sources
(1) Molecular insights into the differences in anti-inflammatory activities of green tea catechins on IL-1β signaling in rheumatoid arthritis synovial fibroblasts by Fechtner S1, Singh A1, Chourasia M2, Ahmed S3.(PubMed)
(2) Anti-inflammatory activity of green versus black tea aqueous extract in a rat model of human rheumatoid arthritis by Ramadan G1, El-Beih NM1, Talaat RM2, Abd El-Ghffar EA1.(PubMed)
(3) Green tea extract inhibits chemokine production, but up-regulates chemokine receptor expression, in rheumatoid arthritis synovial fibroblasts and rat adjuvant-induced arthritis by Marotte H1, Ruth JH, Campbell PL, Koch AE, Ahmed S.(PubMed)

#Phytochemical #Allicin Activates Proteins Associated with Cancer Cell Death through Degradation, According to Studies

Kyle J. Norton

Gastric cancer is a condition caused by abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
At the later stage, liver cancer cells may travel a distance away from the liver to infect other healthy tissue, leading to secondary metastasis through blood and fluids circulation.

According to the American Cancer Society, every year, approximately 26,000 cases of stomach cancer will be diagnosed (16,000 in men and 9,000 in women). Cancer causes the death of over10,000 people, including 6,000 men and 4,000 women).

The cause of gastric cancer is a result of the alternation of cell DNA in the stomach. Researchers do not know what causes the cell DNA alternation, but they do know certain risk factors such as smoking, family history, genetic preposition, certain diseases associated with the stomach and previous stomach surgery are involved in the onset of the disease.

However, some researchers suggested that infection caused by Helicobacter pylori is the most important risk factor for gastric cancer.

Dr. Lydia E. Wroblewski, the lead author examined the effects of Helicobacter pylori in the risk of gastric cancer and wrote, "Helicobacter pylori is a gastric pathogen that colonizes approximately 50% of the world's population. Infection with H. pylori causes chronic inflammation and significantly increases the risk of developing duodenal and gastric ulcer disease and gastric cancer".

And, "Infection with H. pylori is the strongest known risk factor for gastric cancer, which is the second leading cause of cancer-related deaths worldwide".

Allicin is a phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.

With an aim to find the natural compound for the treatment of gastric cancer with no side effects, researchers evaluated the allicin, an active compound derived from garlic anti-cancer effects.

Allicin injection reduced cell viability in a dose- and time-dependent manner, partly through induction of apoptosis in gastric cancer cells.

At the molecular level, allicin induced cancer death through the degradation of cancer cells through activation of the proteins associated with the stimulation of cell apoptosis, including the caspase-3, -8, and -9 and Bax and fas expression.

Allicin treatment also inhibited proliferation and induced apoptosis in SGC-7901 cancer cells.

Dr. the lead researcher said, "Data from the current study demonstrated that allicin should be further investigated as a novel cancer preventive or therapeutic agent in control of gastric cancer, with potential uses in other tumor types".

In a total of patients with progressive gastric adenocarcinoma, whose diagnosis was by gastroscopy and pathological examination assigned to 2 groups, 40 in each group, researchers examined the effects of local application of allicin via gastroscopy on progressive gastric carcinoma.

Allicin group showed the cell apoptosis rate of 9.60 +/- 1.52%, the percentage of cell in G0/G1 phase of 72.12 +/- 8.35%, in G2/M phase 9.54 +/- 3.20%, and PI 27.80 +/- 8.35, compared to the rate of 2.20 +/- 0.58%, 69.56 +/- 5.15%, 13.20 +/- 3.05%, and 30.40 +/- 5.15 in control.

The efficacy of allicin was attributed to the inhibition of the function of a protein (gene Bcl-2) associated with cancer cell anti-apoptosis and exhibition of the function of proteins (gene Bax and Fas) associated with the pro-apoptosis.

These results suggested that local application of allicin via gastroscopy can inhibit the cell growth and proliferation of progressive gastric carcinoma, and can also promote gastric carcinoma cell apoptosis, according to the final report by Fourth Affiliated Hospital of Hebei Medical University.


Taken altogether, phytochemical allicin may be considered a bioactive compound for the prevention and combined with the primary medicine for the treatment of gastric cancer

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways by Zhang W, Ha M, Gong Y, Xu Y, Dong N, Yuan Y.(PubMed)
(2) [Effect of local application of allicinvia gastroscopy on cell proliferation and apoptosis of progressive gastric carcinoma].[Article in Chinese] by Zhang ZD, Li Y, Jiao ZK.(PubMed)
(3) Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk by Lydia E. Wroblewski,1,* Richard M. Peek, Jr.,1,2,3 and Keith T. Wilson. (PMC)