Kyle J. Norton
The esophagus formed part of the digestive system is a muscular tube that connects the throat (pharynx) with the stomach located behind the trachea and heart and in front of the spine.
Cancer is a group of chronic diseases associated with irregular cell growth that starts in the cell on the surface of the inner lining tissue of the specific gland and organ before penetrating into deeper layers to form tumors through unlimited cell cycle division.
Over time, most cancers have become progressively worse and spread to other organs in the body via lymph or blood.
Esophageal cancer is not very uncommon in the US caused by malignant cells of the esophagus due to cell DNA alternation.
Primary esophageal cancer has been found to spread to the bottom of the esophagus, stomach, and chest.
According to the statistics, compared to the US, esophageal cancer is more often diagnosed in other parts of the world and is the seventh most common cause of cancer death among men.
Believe it or not, every year, the disease causes the death of 16,000 individuals, including 13,000 men and 3,000 women,
Compared to other cancers the 5-year survival rate for people with esophageal cancer is only 19%.
The exact causes of esophageal cancer are unidentified. However, according to epidemiological studies, aging, male gender, smoking, excessive alcohol drinking, genetic preposition, obesity, and thermal injury to the esophagus are some prevalent factors that increase the risk of the disease.
Some researchers suggested that the increased incidences of esophageal cancer in the Western world over the past few decades may be correlated to the promotion of a high-fat diet.
Dr. Silvano Gallus wrote, "Over the last 30 years, the incidence of squamous-cell carcinoma has decreased in several areas of the world, but adenocarcinoma has risen by over fourfold in the US as well as in Australia and several areas of Europe; its incidence has particularly increased in men".
And, " diets high in saturated fat and cholesterol have been associated with an increased risk (of esophageal cancer)".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of gastrointestinal tumors, researchers examined the effect of a purified cranberry-derived proanthocyanidin extract (C-PAC) on esophageal adenocarcinoma (EAC) cell lines, including acid-sensitive JHAD1 and OE33 cells, and esophageal tumor xenografts in athymic NU/NU mice.
According to the tested assays, C-PAC shared a strong activity in inducing the expression of a protein associated with cell death programming mainly in JHAD1 and OE33 cells.
Autophagy that promotes cancer cell growth and anti-apoptosis of JHAD1 and OE33 cells were also inhibited by the injection of C-PAC.
In vitro, C-PAC-induced cell death was attributed to the deactivation of the phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin (mTOR) signaling pathways expression in the promotion of cancer cellular processes, including cell survival, growth, and differentiation.
Additionally, C-PAC not only inhibited the levels of anti-apoptotic proteins such as BCL-xL, Cytochrome C, PARP), pathways involved in the occurrence and progression of cancer but also exhibited the expression of proteins that induce cell cycle arrest.
Similarly, in vivo, oral delivery of C-PAC significantly inhibited OE19 tumor xenograft growth as the aforementioned activities.
In other words, in vitro and vivo purified cranberry-derived proanthocyanidin extract (C-PAC) eradicates the esophageal adenocarcinoma (EAC) cells through several mechanisms involved in pro-apoptosis, anti-anti-apoptosis, and blocking cellular division.
Based on the finding, researchers after taking other factors into account wrote, " C-PAC is a potent inducer of EAC cell death and is efficacious in vivo at non-toxic behaviorally achievable concentrations, holding promise for preventive or therapeutic interventions in cohorts at increased risk for EAC, a rapidly rising and extremely deadly malignancy".
Taken altogether, cranberry extract may be considered a remedy for the prevention and treatment of esophageal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary feeding of freeze-dried whole cranberry inhibits intestinal tumor development in Apcmin/+ mice by Jin D#1, Liu T#1, Dong W1, Zhang Y2, Wang S1, Xie R1, Wang B1, Cao H. (PubMed)
(2) Is There a Link Between Diet and Esophageal Cancer? by Silvano Gallus, and Carlo La Vecchia. (Medscape)
Sunday, 8 October 2023
The #Coffee and Coffee Caffeine Effects on Menopause Symptoms, Researchers Show
Kyle J. Norton
Menopause is a natural and biological progression of women at a certain age. The reduced hormone levels of the inaction of ovaries induced menstruation stop and a set of symptoms
Coffee, second to green tea, is a popular and social beverage all over the world, particularly in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.
A study conducted by a renowned institute suggested that coffee and coffee caffeine may have a potential effect in reduced severity of some menopause symptoms and elevation of others.
In a cross-sectional survey conducted using the Menopause Health Questionnaire, completed by 2,507 consecutive women with menopausal concerns at the Women's Health Clinic at Mayo Clinic (Rochester, MN) between July 25, 2005, and July 25, 2011, caffeine intake in participants showed a greater positive effect in the expression of a vasomotor symptom of menopause women in compared to nondrinkers group.
Other, in a cross-sectional study of a community-based sample of 243 women with vasomotor symptoms to evaluate the menopause symptoms of hot flashes (HF) and night sweats (NS) in symptomatic middle-aged women, intake of coffee showed to elevate symptom of hot flashes (HF) and night sweats (NS) in compared to nondrinkers.
And caffeine intake also is found as one of the predictors in exhibited both hot flashes (HF) and night sweats (NS) in the same study group.
But in the animal model, according to the behavioral tests and oxidative stress parameters in ovariectomized mice, caffeine intake also showed a significant in reduced symptoms of anxiety induced by oxidative stress.
Administration of low doses of caffeine, for a short period of time, maybe a new therapeutic approach to modulate the oxidative stress and anxiety in menopause, the "Iuliu Hatieganu" University of Medicine and Pharmacy postulated.
Taken together, coffee and coffee caffeine may have a strong effect in reduced and elevated menopause symptoms, in types depending manner.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated foShorty Awarded over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Caffeine and menopausal symptoms: what is the association? by Faubion SS1, Sood R, Thielen JM, Shuster LT. (PubMed)
(2) Perceived control, lifestyle, health, socio-demographic factors and menopause: impact on hot flashes and night sweats by Pimenta F1, Leal I, Maroco J, Ramos C.(PubMed)
(3) Modulatory effects of caffeine on oxidative stress and anxiety-like behavior in ovariectomized rats by Caravan I1,1, Sevastre Berghian A1,1, Moldovan R1,1, Decea N1,1, Orasan R1,1, Filip GA1,1.(PubMed)
Menopause is a natural and biological progression of women at a certain age. The reduced hormone levels of the inaction of ovaries induced menstruation stop and a set of symptoms
Coffee, second to green tea, is a popular and social beverage all over the world, particularly in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.
A study conducted by a renowned institute suggested that coffee and coffee caffeine may have a potential effect in reduced severity of some menopause symptoms and elevation of others.
In a cross-sectional survey conducted using the Menopause Health Questionnaire, completed by 2,507 consecutive women with menopausal concerns at the Women's Health Clinic at Mayo Clinic (Rochester, MN) between July 25, 2005, and July 25, 2011, caffeine intake in participants showed a greater positive effect in the expression of a vasomotor symptom of menopause women in compared to nondrinkers group.
Other, in a cross-sectional study of a community-based sample of 243 women with vasomotor symptoms to evaluate the menopause symptoms of hot flashes (HF) and night sweats (NS) in symptomatic middle-aged women, intake of coffee showed to elevate symptom of hot flashes (HF) and night sweats (NS) in compared to nondrinkers.
And caffeine intake also is found as one of the predictors in exhibited both hot flashes (HF) and night sweats (NS) in the same study group.
But in the animal model, according to the behavioral tests and oxidative stress parameters in ovariectomized mice, caffeine intake also showed a significant in reduced symptoms of anxiety induced by oxidative stress.
Administration of low doses of caffeine, for a short period of time, maybe a new therapeutic approach to modulate the oxidative stress and anxiety in menopause, the "Iuliu Hatieganu" University of Medicine and Pharmacy postulated.
Taken together, coffee and coffee caffeine may have a strong effect in reduced and elevated menopause symptoms, in types depending manner.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated foShorty Awarded over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Caffeine and menopausal symptoms: what is the association? by Faubion SS1, Sood R, Thielen JM, Shuster LT. (PubMed)
(2) Perceived control, lifestyle, health, socio-demographic factors and menopause: impact on hot flashes and night sweats by Pimenta F1, Leal I, Maroco J, Ramos C.(PubMed)
(3) Modulatory effects of caffeine on oxidative stress and anxiety-like behavior in ovariectomized rats by Caravan I1,1, Sevastre Berghian A1,1, Moldovan R1,1, Decea N1,1, Orasan R1,1, Filip GA1,1.(PubMed)
#Phytochemical Indole-3-carbinol #I3C Inhibits the Expression of miR-21 Associated with #PancreaticCancer, Reserachers Show
Kyle J. Norton
Scientists may have found a bioactive compound for the prevention and treatment of pancreatic cancer, according to studies.
Cancer of the pancreas or pancreatic cancer is a condition of a malignant neoplasm of the pancreas.
Most cases of primary pancreatic cancer start in the cells on the surface of the inner lining of the pancreas as a result of irregular cell growth caused by the alternation of DNA.
The pancreatic cancers start in the ducts (an exocrine component of the pancreas) carried pancreatic juices with cancer of an epithelium that originates in glandular tissue and accounts for over 75 - 90% of all cases of exocrine cancers.
According to the statistics, pancreatic cancer is the fourth leading cause of cancer death in both men and women in the US. Cancer has the poorest prognosis compared to other major types of cancer, with a 5-year survival rate of approximately 5%.
More precisely, in the US, the age-adjusted incidence of pancreatic cancer is higher in men compared to women regardless of ethnicity.
Epidemiologically, the increase in age, gender, ethnicity, smoking, being obese and obese, and certain medical conditions such as diabetes, and family history are associated with an increased risk of pancreatic cancer.
Some researchers suggested that genetic preposition also places the carrier at a greater risk for the onset of the disease.
Dr. Alison P. Klein, in the joint study led by the Johns Hopkins University School of Medicine, Baltimore, Maryland suggested people who carry the mutated gene BRCA2 or PALB2 and genetic variation at the ABO blood group locus are associated with a modest increased risk of pancreatic cancer.
Indole-3-carbinol is a phytochemical in the class of Indoles, by the breaking down of the glucosinolate glucobrassicin, found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.
In finding the natural ingredient for the treatment of pancreatic cancer without inducing chemoresistance due to the overexpression of microRNA-21 (miR-21), researchers at the Seoul National University College of Medicine evaluated the efficacy of indole-3-carbinol (I3C) in suppressing miR-21 expression.
Where miR-21 simultaneously regulates multiple programs that enhance cell proliferation, apoptosis, and tumor invasiveness by targeting the genes associated with cancer proliferation.
In human pancreatic cancer cells (Panc-1), injection of 13C inhibited the expression of miR-21 positively correlated in a time- and dose-dependent manner.
13C and gemcitabine combination therapy increased cytotoxicity in Panc-1 cells.
The efficacy of 13C was attributed to its activity in promoting cancer cell apoptosis by attenuating miR-21 transfection.
The finding suggested that I3C would be effective in enhancing the sensitivity of pancreatic cancer cells to gemcitabine via the inhibition of the overexpression of miR-21.
An additional experiment demonstrating the ability of a dietary agent, indole-3-carbinol (I3C), to lower the LD(50) of gemcitabine (Gemzar) in decreasing growth of both male (MiaPaca2) and female (SU86.86) pancreatic cancer cells, researchers found that* Without an injection of 13C, female pancreatic cancer cells were more resistant to gemcitabine.
* In male MiaPaca2 cells application of 1, 10, or 100 μM of I3C induced apoptosis by reactivating the tumor suppressor gene in pancreatic cancer cells.
* 13C also protects the healthy pancreas cells by enhancing the activity of the tumor suppressor gene.
Moreover, by examining the DNA methylation researchers suggested suppressor tumor gene (p16INK4a) inactivation in the promotion of hypermethylation is considered an early event in pancreatic carcinogenesis.
DNA methylation is a process by which methyl groups are added to the DNA molecule.
These results clearly indicated, that I3C, a possible non-toxic hypomethylating agent, combined with the anticancer agent, gemcitabine, is a powerful strategy for treating pancreatic cancer.
Taken altogether, the bioactive compound indole-3-carbinol (I3C) may be used for the prevention and treatment of pancreas cancer, pending the results of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chemosensitivity induced by down-regulation of microRNA-21 in gemcitabine-resistant pancreatic cancer cells by indole-3-carbinol by Paik WH1, Kim HR, Park JK, Song BJ, Lee SH, Hwang JH.(PubMed)
(2) Gender differences in gemcitabine (Gemzar) efficacy in cancer cells: effect of indole-3-carbinol. by Lyn-Cook BD1, Mohammed SI, Davis C, Word B, Haefele A, Wang H, Hammons G.(PubMed)
(3) Enhanced efficacy of gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrative nucleoside transporter 1 by Wang H1, Word BR, Lyn-Cook BD. (PubMed)
(4) Genetic Susceptibility to Pancreatic Cancer by Alison P. Klein. (PMC)
Scientists may have found a bioactive compound for the prevention and treatment of pancreatic cancer, according to studies.
Cancer of the pancreas or pancreatic cancer is a condition of a malignant neoplasm of the pancreas.
Most cases of primary pancreatic cancer start in the cells on the surface of the inner lining of the pancreas as a result of irregular cell growth caused by the alternation of DNA.
The pancreatic cancers start in the ducts (an exocrine component of the pancreas) carried pancreatic juices with cancer of an epithelium that originates in glandular tissue and accounts for over 75 - 90% of all cases of exocrine cancers.
According to the statistics, pancreatic cancer is the fourth leading cause of cancer death in both men and women in the US. Cancer has the poorest prognosis compared to other major types of cancer, with a 5-year survival rate of approximately 5%.
More precisely, in the US, the age-adjusted incidence of pancreatic cancer is higher in men compared to women regardless of ethnicity.
Epidemiologically, the increase in age, gender, ethnicity, smoking, being obese and obese, and certain medical conditions such as diabetes, and family history are associated with an increased risk of pancreatic cancer.
Some researchers suggested that genetic preposition also places the carrier at a greater risk for the onset of the disease.
Dr. Alison P. Klein, in the joint study led by the Johns Hopkins University School of Medicine, Baltimore, Maryland suggested people who carry the mutated gene BRCA2 or PALB2 and genetic variation at the ABO blood group locus are associated with a modest increased risk of pancreatic cancer.
Indole-3-carbinol is a phytochemical in the class of Indoles, by the breaking down of the glucosinolate glucobrassicin, found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.
In finding the natural ingredient for the treatment of pancreatic cancer without inducing chemoresistance due to the overexpression of microRNA-21 (miR-21), researchers at the Seoul National University College of Medicine evaluated the efficacy of indole-3-carbinol (I3C) in suppressing miR-21 expression.
Where miR-21 simultaneously regulates multiple programs that enhance cell proliferation, apoptosis, and tumor invasiveness by targeting the genes associated with cancer proliferation.
In human pancreatic cancer cells (Panc-1), injection of 13C inhibited the expression of miR-21 positively correlated in a time- and dose-dependent manner.
13C and gemcitabine combination therapy increased cytotoxicity in Panc-1 cells.
The efficacy of 13C was attributed to its activity in promoting cancer cell apoptosis by attenuating miR-21 transfection.
The finding suggested that I3C would be effective in enhancing the sensitivity of pancreatic cancer cells to gemcitabine via the inhibition of the overexpression of miR-21.
An additional experiment demonstrating the ability of a dietary agent, indole-3-carbinol (I3C), to lower the LD(50) of gemcitabine (Gemzar) in decreasing growth of both male (MiaPaca2) and female (SU86.86) pancreatic cancer cells, researchers found that* Without an injection of 13C, female pancreatic cancer cells were more resistant to gemcitabine.
* In male MiaPaca2 cells application of 1, 10, or 100 μM of I3C induced apoptosis by reactivating the tumor suppressor gene in pancreatic cancer cells.
* 13C also protects the healthy pancreas cells by enhancing the activity of the tumor suppressor gene.
Moreover, by examining the DNA methylation researchers suggested suppressor tumor gene (p16INK4a) inactivation in the promotion of hypermethylation is considered an early event in pancreatic carcinogenesis.
DNA methylation is a process by which methyl groups are added to the DNA molecule.
These results clearly indicated, that I3C, a possible non-toxic hypomethylating agent, combined with the anticancer agent, gemcitabine, is a powerful strategy for treating pancreatic cancer.
Taken altogether, the bioactive compound indole-3-carbinol (I3C) may be used for the prevention and treatment of pancreas cancer, pending the results of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chemosensitivity induced by down-regulation of microRNA-21 in gemcitabine-resistant pancreatic cancer cells by indole-3-carbinol by Paik WH1, Kim HR, Park JK, Song BJ, Lee SH, Hwang JH.(PubMed)
(2) Gender differences in gemcitabine (Gemzar) efficacy in cancer cells: effect of indole-3-carbinol. by Lyn-Cook BD1, Mohammed SI, Davis C, Word B, Haefele A, Wang H, Hammons G.(PubMed)
(3) Enhanced efficacy of gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrative nucleoside transporter 1 by Wang H1, Word BR, Lyn-Cook BD. (PubMed)
(4) Genetic Susceptibility to Pancreatic Cancer by Alison P. Klein. (PMC)
#Carotenoids Inhibits the Risk of #ColorectalCancer in Patients with DICER1 rs3742330 Genotypeancer, Researchers Say
Kyle J. Norton
Cancer is a class of diseases associated with irregular cell growth in the tissue of organs.
The colon-rectum formed as a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances which some of them to be reabsorbed and reused by the body.
Colorectal cancer is cancer located in the colon or rectum caused alternation of cell DNA. Most cases of colorectal cancer begin in the cells on the surface of inner ling tissue in either the colon or rectum, before multiplying to form a tumor.
Colorectal cancer is relatively very common and slowly growing and progressing cancer.
The disease is also the third most commonly diagnosed cancer in developed countries, including the US and Canada.
According to the statistics provided by the American Cancer Society, in the US,
101,420 new cases of colon cancer and 44,180 new cases of rectal cancer will be diagnosed in 2019.
Additionally, colorectal cancer will also cause the death of 51,020 Americans in 2019.
Overall, the lifetime risk of colorectal cancer developing is 1 in 22 (4.49%) in men and 1 in 24 (4.15%) in women.
Besides adenocarcinomas, the common type of colorectal cancer originates in epithelium tissues and squamous cells that make up the bowel lining together with the gland cells, other types of colorectal tumors include
* Carcinoid
Carcinoid is an unusual type of slow growth neuroendocrine tumor in the hormone-producing tissue in the digestive system. The condition may look benign but can spread to other parts of the body as they grow
* Leiomyosarcomas
Leiomyosarcomas are the rare and resistant type of colorectal cancer and generally not very responsive to chemotherapy or radiation. They are a malignant abnormal mass of tissue of smooth muscles of the colon, comprising between 5–10% of soft tissue sarcomas.
* Lymphomas
Bowel lymphomas are rare and more likely to start in the rectum rather in the colon. Many patients with lymphomas are diagnosed in the late stage and already spread to other organs.
* Melanomas
Melanomas are a rare malignant tumor of cells that produce the dark pigment. This type of bowel cancer usually originates from somewhere else and then spread to the bowel.
Carotenoids are a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
On finding a potential compound for the treatment of colorectal cancer, researchers investigated whether dietary lutein/zeaxanthin, the major compounds found in carotenoid intake affect colorectal cancer risk in patients with a DICER1 rs3742330 polymorphism.
The experiment included 923 colorectal cancer patients and 1,846 controls based on eligibility criteria, that answered the semiquantitative food frequency questionnaire and the DICER1 rs3742330 genotype.
Based on the returned questionnaire differentiation, the highest quartile of lutein/zeaxanthin consumption was inversely associated with colorectal cancer risk.
In genotype analysis, patients who carry the G allele (AG + GG) showed a significantly reduced colorectal cancer incidence compared to AA carriers.
Furthermore, patients with the G allele (AG + GG) along with high lutein/zeaxanthin consumption were markedly associated with a decreased colorectal cancer risk, particularly in rectal cancer compared to that of AA carriers with low lutein/zeaxanthin intakes.
The results strongly suggested that carotenoids major compounds lutein/zeaxanthin has a strong implication on the colorectal cancer risk in patients with DICER1 rs3742330 genotype.
Dr. Kim J, the lead scientist after taking into account co and confounders wrote in the final report, "Colorectal cancer risk was related to an interactive effect between dietary lutein/zeaxanthin intake and the DICER1 rs3742330 polymorphism".
Taken together, carotenoids may be considered a remedy for the prevention and treatment of colorectal cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition by Leenders M1, Leufkens AM, Siersema PD, van Duijnhoven FJ, Vrieling A, Hulshof PJ, van Gils CH, Overvad K, Roswall N, Kyrø C, Boutron-Ruault MC, Fagerhazzi G, Cadeau C, Kühn T, Johnson T, Boeing H, Aleksandrova K, Trichopoulou A, Klinaki E, Androulidaki A, Palli D, Grioni S, Sacerdote C, Tumino R, Panico S, Bakker MF, Skeie G, Weiderpass E, Jakszyn P, Barricarte A, María Huerta J, Molina-Montes E, Argüelles M, Johansson I, Ljuslinder I, Key TJ, Bradbury KE, Khaw KT, Wareham NJ, Ferrari P, Duarte-Salles T, Jenab M, Gunter MJ, Vergnaud AC, Wark PA, Bueno-de-Mesquita HB. (PubMed)
(2) Antiproliferative effects of carotenoids extracted from Chlorella ellipsoidea and Chlorella vulgaris on human colon cancer cells by Cha KH1, Koo SY, Lee DU. (PubMed)
Cancer is a class of diseases associated with irregular cell growth in the tissue of organs.
The colon-rectum formed as a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances which some of them to be reabsorbed and reused by the body.
Colorectal cancer is cancer located in the colon or rectum caused alternation of cell DNA. Most cases of colorectal cancer begin in the cells on the surface of inner ling tissue in either the colon or rectum, before multiplying to form a tumor.
Colorectal cancer is relatively very common and slowly growing and progressing cancer.
The disease is also the third most commonly diagnosed cancer in developed countries, including the US and Canada.
According to the statistics provided by the American Cancer Society, in the US,
101,420 new cases of colon cancer and 44,180 new cases of rectal cancer will be diagnosed in 2019.
Additionally, colorectal cancer will also cause the death of 51,020 Americans in 2019.
Overall, the lifetime risk of colorectal cancer developing is 1 in 22 (4.49%) in men and 1 in 24 (4.15%) in women.
Besides adenocarcinomas, the common type of colorectal cancer originates in epithelium tissues and squamous cells that make up the bowel lining together with the gland cells, other types of colorectal tumors include
* Carcinoid
Carcinoid is an unusual type of slow growth neuroendocrine tumor in the hormone-producing tissue in the digestive system. The condition may look benign but can spread to other parts of the body as they grow
* Leiomyosarcomas
Leiomyosarcomas are the rare and resistant type of colorectal cancer and generally not very responsive to chemotherapy or radiation. They are a malignant abnormal mass of tissue of smooth muscles of the colon, comprising between 5–10% of soft tissue sarcomas.
* Lymphomas
Bowel lymphomas are rare and more likely to start in the rectum rather in the colon. Many patients with lymphomas are diagnosed in the late stage and already spread to other organs.
* Melanomas
Melanomas are a rare malignant tumor of cells that produce the dark pigment. This type of bowel cancer usually originates from somewhere else and then spread to the bowel.
Carotenoids are a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
On finding a potential compound for the treatment of colorectal cancer, researchers investigated whether dietary lutein/zeaxanthin, the major compounds found in carotenoid intake affect colorectal cancer risk in patients with a DICER1 rs3742330 polymorphism.
The experiment included 923 colorectal cancer patients and 1,846 controls based on eligibility criteria, that answered the semiquantitative food frequency questionnaire and the DICER1 rs3742330 genotype.
Based on the returned questionnaire differentiation, the highest quartile of lutein/zeaxanthin consumption was inversely associated with colorectal cancer risk.
In genotype analysis, patients who carry the G allele (AG + GG) showed a significantly reduced colorectal cancer incidence compared to AA carriers.
Furthermore, patients with the G allele (AG + GG) along with high lutein/zeaxanthin consumption were markedly associated with a decreased colorectal cancer risk, particularly in rectal cancer compared to that of AA carriers with low lutein/zeaxanthin intakes.
The results strongly suggested that carotenoids major compounds lutein/zeaxanthin has a strong implication on the colorectal cancer risk in patients with DICER1 rs3742330 genotype.
Dr. Kim J, the lead scientist after taking into account co and confounders wrote in the final report, "Colorectal cancer risk was related to an interactive effect between dietary lutein/zeaxanthin intake and the DICER1 rs3742330 polymorphism".
Taken together, carotenoids may be considered a remedy for the prevention and treatment of colorectal cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition by Leenders M1, Leufkens AM, Siersema PD, van Duijnhoven FJ, Vrieling A, Hulshof PJ, van Gils CH, Overvad K, Roswall N, Kyrø C, Boutron-Ruault MC, Fagerhazzi G, Cadeau C, Kühn T, Johnson T, Boeing H, Aleksandrova K, Trichopoulou A, Klinaki E, Androulidaki A, Palli D, Grioni S, Sacerdote C, Tumino R, Panico S, Bakker MF, Skeie G, Weiderpass E, Jakszyn P, Barricarte A, María Huerta J, Molina-Montes E, Argüelles M, Johansson I, Ljuslinder I, Key TJ, Bradbury KE, Khaw KT, Wareham NJ, Ferrari P, Duarte-Salles T, Jenab M, Gunter MJ, Vergnaud AC, Wark PA, Bueno-de-Mesquita HB. (PubMed)
(2) Antiproliferative effects of carotenoids extracted from Chlorella ellipsoidea and Chlorella vulgaris on human colon cancer cells by Cha KH1, Koo SY, Lee DU. (PubMed)
#Cabbage Stimulates Protein Associated with Cell Survival and Against Apoptosis Caused Overexpression of Oxidative Stress
Kyle J. Norton
Mitochondria are the cell that converts food molecules into energy for the body tissues' needs. Mitochondria produce 90 percent of the energy for the body's function.
Mitochondrial dysfunction is a condition affecting the organelles that generate energy for the cell.
Genetically, the genetic proposition has been found to alter the process of mitochondria in converting oxygen and food to energy in some people.
Acquired mitochondrial dysfunction is caused by the long-term use of certain medications such as Metformin, medical conditions such as mitochondrial encephalomyopathy or infection, and environmental influences, such as xenochemicals, leading to less and less energy generated within the cells.
Acquired mitochondrial dysfunction has been found in patients with Alzheimer’s disease, muscular dystrophy, Lou Gehrig’s disease, diabetes, and cancer.
The most common symptoms of mitochondrial dysfunction include poor growth, muscle weakness, muscle pain, low muscle tone, exercise intolerance, vision and/or hearing problems
learning disabilities, delays in development, and mental retardation depending on the location of the infected cells.
Diseases associated with mitochondrial dysfunction include Autism, autism-like features Heart, liver or kidney diseases, seizures, strokes, severe developmental delays, inability to walk, and dementia.
Conventionally, treatments for mitochondrial dysfunction are totally depending on the causes of the disease.
Dr. Sreenivas Avula, the lead scientist wrote, "Classification of therapies for mitochondrial disorders has evolved from the empirical therapies targeting residual respiratory chain to acting at the molecular level to alter the expression of mutated mtDNA genes within the cell nucleus".
And, " ...in the future, treatment strategies may employ a combination of pharmacological treatments that have undergone rigorous clinical trials targeting OXPHOS, as well as newer strategies at the molecular level".
Cabbage is a species of Brassica oleracea belonging to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem that is crowded with a mass of leaves, usually green but in some varieties, it may be red or purplish.
With an aim to find a natural food for the prevention of oxidative stress in the progression of cardiac diseases, researchers examined the effect of cabbage extract on mitochondrial dysfunction in H9c2 cardiomyoblasts.
According to the tested differentiation, the administration of cabbage extract protected the mitochondria against H2O2-induced cell death without eliciting cytotoxic effects.
Furthermore, cabbage extract enhanced the expression of antioxidant proteins (SOD-1, catalase, and GPx) against ROS production.
Moreover, the extracts also stimulate the protein associated with cell survival by inhibiting apoptotic responses in oxidative stress-exposed H9c2 cells.
More precisely, cabbage extract preserved mitochondrial functions upon oxidative stress.
Based on the results, researchers wrote, "These findings reveal that cabbage extract protects against oxidative stress and suggest that it can be used as an alternative therapeutic strategy to prevent the oxidative stress in the heart".
Taken together, cabbage processed abundantly SFN may be considered a remedy for the prevention and treatment of mitochondrial dysfunction in the initiation of heart disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cabbage (Brassica oleracea var. capitata) Protects against H2o2-induced oxidative Stress by Preventing Mitochondrial Dysfunction in H9c2 Cardiomyoblasts by Yang DK. (PubMed)
(2) Treatment of Mitochondrial Disorders by Sreenivas Avula,1 Sumit Parikh, MD,1 Scott Demarest, MD,2 Jonathan Kurz, MD,2 and Andrea Gropman, MD. (PMC)
Mitochondria are the cell that converts food molecules into energy for the body tissues' needs. Mitochondria produce 90 percent of the energy for the body's function.
Mitochondrial dysfunction is a condition affecting the organelles that generate energy for the cell.
Genetically, the genetic proposition has been found to alter the process of mitochondria in converting oxygen and food to energy in some people.
Acquired mitochondrial dysfunction is caused by the long-term use of certain medications such as Metformin, medical conditions such as mitochondrial encephalomyopathy or infection, and environmental influences, such as xenochemicals, leading to less and less energy generated within the cells.
Acquired mitochondrial dysfunction has been found in patients with Alzheimer’s disease, muscular dystrophy, Lou Gehrig’s disease, diabetes, and cancer.
The most common symptoms of mitochondrial dysfunction include poor growth, muscle weakness, muscle pain, low muscle tone, exercise intolerance, vision and/or hearing problems
learning disabilities, delays in development, and mental retardation depending on the location of the infected cells.
Diseases associated with mitochondrial dysfunction include Autism, autism-like features Heart, liver or kidney diseases, seizures, strokes, severe developmental delays, inability to walk, and dementia.
Conventionally, treatments for mitochondrial dysfunction are totally depending on the causes of the disease.
Dr. Sreenivas Avula, the lead scientist wrote, "Classification of therapies for mitochondrial disorders has evolved from the empirical therapies targeting residual respiratory chain to acting at the molecular level to alter the expression of mutated mtDNA genes within the cell nucleus".
And, " ...in the future, treatment strategies may employ a combination of pharmacological treatments that have undergone rigorous clinical trials targeting OXPHOS, as well as newer strategies at the molecular level".
Cabbage is a species of Brassica oleracea belonging to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem that is crowded with a mass of leaves, usually green but in some varieties, it may be red or purplish.
With an aim to find a natural food for the prevention of oxidative stress in the progression of cardiac diseases, researchers examined the effect of cabbage extract on mitochondrial dysfunction in H9c2 cardiomyoblasts.
According to the tested differentiation, the administration of cabbage extract protected the mitochondria against H2O2-induced cell death without eliciting cytotoxic effects.
Furthermore, cabbage extract enhanced the expression of antioxidant proteins (SOD-1, catalase, and GPx) against ROS production.
Moreover, the extracts also stimulate the protein associated with cell survival by inhibiting apoptotic responses in oxidative stress-exposed H9c2 cells.
More precisely, cabbage extract preserved mitochondrial functions upon oxidative stress.
Based on the results, researchers wrote, "These findings reveal that cabbage extract protects against oxidative stress and suggest that it can be used as an alternative therapeutic strategy to prevent the oxidative stress in the heart".
Taken together, cabbage processed abundantly SFN may be considered a remedy for the prevention and treatment of mitochondrial dysfunction in the initiation of heart disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cabbage (Brassica oleracea var. capitata) Protects against H2o2-induced oxidative Stress by Preventing Mitochondrial Dysfunction in H9c2 Cardiomyoblasts by Yang DK. (PubMed)
(2) Treatment of Mitochondrial Disorders by Sreenivas Avula,1 Sumit Parikh, MD,1 Scott Demarest, MD,2 Jonathan Kurz, MD,2 and Andrea Gropman, MD. (PMC)
#Phytochemical 3,3'-Diindolylmethane Inhibits Expressions Associated with Renal Fibrosis, According to Studies
Kyle J. Norton
Renal fibrosis is a progressive condition caused by excessive accumulation of extracellular matrix including collagen, enzymes, and glycoproteins which provided structural and biochemical support of surrounding the renal cells during aging and chronic kidney disease (CKD).
According to the statistics, CKD and renal fibrosis affect approximately half of the adults age 70 and over and 10% of the world's population.
In other words, renal fibrosis is a direct consequence caused by the inability of the kidney to regenerate after injury, leading to the formation of renal scars that results in a progressive loss of renal function.
Most cases of renal fibrosis ultimately lead to end-stage renal failure and a need for dialysis or kidney transplantation.
At the early stage of renal fibrosis, patients may experience symptoms of dull pain in the abdomen or back, pain on one side between your upper abdomen and back, leg pain. discoloration swelling in one or both legs.
If you have some of the aforementioned symptoms, you may have renal fibrosis, please make sure that you check with your doctor to rule out the possibility.
From the dialysis point of view of patients with renal fibrosis, Dr. Menn-Josephy H in examined the risk of dialysis in patients with renal fibrosis and wrote, "Surprisingly, 13.9% of patients with normal renal function had 25-49% fibrosis and 5% had more than 50% fibrosis on biopsy, and 5 years after undergoing biopsy 21% of patients with >50% fibrosis still remained dialysis-free. Conclusion: Renal fibrosis is an imperfect prognostic indicator for the development of ESRD and caution should be exercised in applying it too rigidly, especially in elderly or diabetic patients".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In the urgency to discover the potential compound for the treatment of renal fibrosis, researchers examined the effects of 3,3'-Diindolylmethane (DIM) a natural acid condensation extracted from cruciferous plants, on renal fibrosis.
DIM has been found to process anti-hepatic and cardiac fibrosis models in a number of studies.
The study included the established unilateral ureteral obstruction (UUO) and transforming growth factor (TGF)-β1-stimulated normal rat kidney (NRK)-49F fibroblast cell mouse models.
Injection of DIM reduced kidney injury and production of interstitial collagens fibrosis.
In the UUO model, DIM inhibited the expression of fibronectin, and collagen-1 associated with the formation of scars but retained E-cadherin involved in the formation of adherens junctions to bind cells with each other.
In other words, DIM protects the renal cells against the induction of renal fibrosis.
In vivo and in vitro, the administration of DIM is also found to suppress local fibroblast activation observed by the levels of myofibroblast markers α-SMA and vimentin.
Most importantly, DIM significantly inhibited the levels of pro-inflammatory cytokine-induced abnormal proliferation of NRK49F cells, in a time- and dose-dependent manner.
Furthermore, DIM also inhibited the expression of Smad2 phosphorylation in the formation of renal scar tissue.
Based on the results, researchers concluded that DIM protects renal cell integrity by inhibiting TGF-β/Smad2/3 signaling against the formation of renal fibrosis.
Taken together, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of renal fibrosis, pending the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane ameliorates renal fibrosis through the inhibition of renal fibroblast activation in vivo and in vitro by Xia ZE1, Xi JL2, Shi L. (PubMed)
(2) Renal Interstitial Fibrosis: An Imperfect Predictor of Kidney Disease Progression in Some Patient by CohortsMenn-Josephy H.a · Lee C.S.a · Nolin A.a · Christov M.c · Rybin D.V.d · Weinberg J.M.e · Henderson J.b · Bonegio R.a · Havasi A.(PubMed)
According to the statistics, CKD and renal fibrosis affect approximately half of the adults age 70 and over and 10% of the world's population.
In other words, renal fibrosis is a direct consequence caused by the inability of the kidney to regenerate after injury, leading to the formation of renal scars that results in a progressive loss of renal function.
Most cases of renal fibrosis ultimately lead to end-stage renal failure and a need for dialysis or kidney transplantation.
At the early stage of renal fibrosis, patients may experience symptoms of dull pain in the abdomen or back, pain on one side between your upper abdomen and back, leg pain. discoloration swelling in one or both legs.
If you have some of the aforementioned symptoms, you may have renal fibrosis, please make sure that you check with your doctor to rule out the possibility.
From the dialysis point of view of patients with renal fibrosis, Dr. Menn-Josephy H in examined the risk of dialysis in patients with renal fibrosis and wrote, "Surprisingly, 13.9% of patients with normal renal function had 25-49% fibrosis and 5% had more than 50% fibrosis on biopsy, and 5 years after undergoing biopsy 21% of patients with >50% fibrosis still remained dialysis-free. Conclusion: Renal fibrosis is an imperfect prognostic indicator for the development of ESRD and caution should be exercised in applying it too rigidly, especially in elderly or diabetic patients".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In the urgency to discover the potential compound for the treatment of renal fibrosis, researchers examined the effects of 3,3'-Diindolylmethane (DIM) a natural acid condensation extracted from cruciferous plants, on renal fibrosis.
DIM has been found to process anti-hepatic and cardiac fibrosis models in a number of studies.
The study included the established unilateral ureteral obstruction (UUO) and transforming growth factor (TGF)-β1-stimulated normal rat kidney (NRK)-49F fibroblast cell mouse models.
Injection of DIM reduced kidney injury and production of interstitial collagens fibrosis.
In the UUO model, DIM inhibited the expression of fibronectin, and collagen-1 associated with the formation of scars but retained E-cadherin involved in the formation of adherens junctions to bind cells with each other.
In other words, DIM protects the renal cells against the induction of renal fibrosis.
In vivo and in vitro, the administration of DIM is also found to suppress local fibroblast activation observed by the levels of myofibroblast markers α-SMA and vimentin.
Most importantly, DIM significantly inhibited the levels of pro-inflammatory cytokine-induced abnormal proliferation of NRK49F cells, in a time- and dose-dependent manner.
Furthermore, DIM also inhibited the expression of Smad2 phosphorylation in the formation of renal scar tissue.
Based on the results, researchers concluded that DIM protects renal cell integrity by inhibiting TGF-β/Smad2/3 signaling against the formation of renal fibrosis.
Taken together, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of renal fibrosis, pending the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane ameliorates renal fibrosis through the inhibition of renal fibroblast activation in vivo and in vitro by Xia ZE1, Xi JL2, Shi L. (PubMed)
(2) Renal Interstitial Fibrosis: An Imperfect Predictor of Kidney Disease Progression in Some Patient by CohortsMenn-Josephy H.a · Lee C.S.a · Nolin A.a · Christov M.c · Rybin D.V.d · Weinberg J.M.e · Henderson J.b · Bonegio R.a · Havasi A.(PubMed)
#Phytochemicals #PhyticAcid Exerts a Strong Anticancer Activity by Inhibiting the Tumor Growth and Cell Proliferation, Researchers Find
Kyle J. Norton
Phytic acid (Inositol hexaphosphate) may have a potential effect in reducing the risk and treatment of cancers, some scientists suggested.
Cancer is a class of chronic diseases associated with the growth of irregular cells that start in the cells of the inner lining of a tissue or organ caused by DNA alternation.
At the advanced stage, cells of the invasive tumor may travel a distance away from the primary site to infect other healthy tissue of the organs, through lymph and blood, leading to secondary metastasis.
Some cancers can be slow-growth such as prostate and colon cancer.
Primary cancer at stage 0 and 1 do not induce any symptoms. However, at the later stage, a larger size tumor can suppress the nearby tissue and nerve cells leading to localized and severe symptoms and pain, depending on the type of cancer.
According to the statistics, in the US, the number of new cases of cancer(cancer incidence) is 439.2 per 100,000 men and women per year (based on 2011–2015 cases). The number of cancer deaths (cancer mortality) is 163.5 per 100,000 men and women per year (based on 2011–2015 deaths).
Cancers who are diagnosed in the early stage have a 5 years survival rate close to 100%. Therefore, the annual examination may be necessary for people who are classified as having a higher risk of cancer development.
The causes of cancer are unknown. researchers cannot explain why people with the same healthy condition, and family history in the same family, are susceptible to the onset of the disease while others do not.
Either they can explain why people who carry some of the risk factors associated with the development of cancer never have cancer, while others having no risk factors are diagnosed with cancer.
Conventionally, the treatment of cancers completely depends on the types and grades of cancer. Some people with cancer at an early stage may only need one treatment. However most people with cancer in the later stage have a combination of treatments, including surgery with chemotherapy and/or radiation therapy.
Phytic acids (Inositol hexaphosphate) are phytochemicals of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.
With an aim to find a natural ingredient for the prevention and treatment of cancers without inducing side effects, researchers examine the anticancer effects of phytic acid (IP6).
In vitro and in vivo phytic acid (IP6) exerted a strong anticancer activity by inhibiting the tumor growth and cell proliferation in a series of cancer cell lines, including colon, nipple, breast, prostate, cervix, liver, pancreas, melanoma, and glioblastoma.
The efficacy of IP6 was probably associated with the promoted antioxidant production, improved signal transduction, enhanced functions of the NK-cells, and exhibited cell cycle arrest and activated proteins associated with cell death programming.
Furthermore, in the findings, the proper role for the treatment of cancer researchers looked into the concentration of IP6 and its lower phosphorylated forms (IP(1-5)),
At the 10 microM to 1 mM concentrations, IP6 and its lower phosphorylated forms (IP(1-5)) showed a potential activity in regulating vital cellular functions such as signal transduction, cell proliferation, and differentiation, similar to those of the previous study.
In vivo and in vitro, exogenously administered IP6 and internalized, IP6 and IP(1-5) inhibited cell growth.
Moreover, researchers found that the application of IP6 not only decreased cellular proliferation but also caused the differentiation of malignant cells often resulting in a reversion to a normal phenotype.
The results strongly indicated that IP6 inhibits the cancer cell lines through a number of mechanisms, including cell cycle regulatory genes, differentiation genes, and tumor suppressor genes.
Taken together, phytic acid (IP6) may be considered an anti-cancer bioactive compound for the prevention and treatment of cancer with no side effects, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) [Phytic acid--anticancer nutriceutic].[Article in Polish] by Nawrocka-Musiał D, Latocha M.(PubMed)
(2) IP6: a novel anti-cancer agent by Shamsuddin AM, Vucenik I, Cole KE.(PubMed)
Phytic acid (Inositol hexaphosphate) may have a potential effect in reducing the risk and treatment of cancers, some scientists suggested.
Cancer is a class of chronic diseases associated with the growth of irregular cells that start in the cells of the inner lining of a tissue or organ caused by DNA alternation.
At the advanced stage, cells of the invasive tumor may travel a distance away from the primary site to infect other healthy tissue of the organs, through lymph and blood, leading to secondary metastasis.
Some cancers can be slow-growth such as prostate and colon cancer.
Primary cancer at stage 0 and 1 do not induce any symptoms. However, at the later stage, a larger size tumor can suppress the nearby tissue and nerve cells leading to localized and severe symptoms and pain, depending on the type of cancer.
According to the statistics, in the US, the number of new cases of cancer(cancer incidence) is 439.2 per 100,000 men and women per year (based on 2011–2015 cases). The number of cancer deaths (cancer mortality) is 163.5 per 100,000 men and women per year (based on 2011–2015 deaths).
Cancers who are diagnosed in the early stage have a 5 years survival rate close to 100%. Therefore, the annual examination may be necessary for people who are classified as having a higher risk of cancer development.
The causes of cancer are unknown. researchers cannot explain why people with the same healthy condition, and family history in the same family, are susceptible to the onset of the disease while others do not.
Either they can explain why people who carry some of the risk factors associated with the development of cancer never have cancer, while others having no risk factors are diagnosed with cancer.
Conventionally, the treatment of cancers completely depends on the types and grades of cancer. Some people with cancer at an early stage may only need one treatment. However most people with cancer in the later stage have a combination of treatments, including surgery with chemotherapy and/or radiation therapy.
Phytic acids (Inositol hexaphosphate) are phytochemicals of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.
With an aim to find a natural ingredient for the prevention and treatment of cancers without inducing side effects, researchers examine the anticancer effects of phytic acid (IP6).
In vitro and in vivo phytic acid (IP6) exerted a strong anticancer activity by inhibiting the tumor growth and cell proliferation in a series of cancer cell lines, including colon, nipple, breast, prostate, cervix, liver, pancreas, melanoma, and glioblastoma.
The efficacy of IP6 was probably associated with the promoted antioxidant production, improved signal transduction, enhanced functions of the NK-cells, and exhibited cell cycle arrest and activated proteins associated with cell death programming.
Furthermore, in the findings, the proper role for the treatment of cancer researchers looked into the concentration of IP6 and its lower phosphorylated forms (IP(1-5)),
At the 10 microM to 1 mM concentrations, IP6 and its lower phosphorylated forms (IP(1-5)) showed a potential activity in regulating vital cellular functions such as signal transduction, cell proliferation, and differentiation, similar to those of the previous study.
In vivo and in vitro, exogenously administered IP6 and internalized, IP6 and IP(1-5) inhibited cell growth.
Moreover, researchers found that the application of IP6 not only decreased cellular proliferation but also caused the differentiation of malignant cells often resulting in a reversion to a normal phenotype.
The results strongly indicated that IP6 inhibits the cancer cell lines through a number of mechanisms, including cell cycle regulatory genes, differentiation genes, and tumor suppressor genes.
Taken together, phytic acid (IP6) may be considered an anti-cancer bioactive compound for the prevention and treatment of cancer with no side effects, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) [Phytic acid--anticancer nutriceutic].[Article in Polish] by Nawrocka-Musiał D, Latocha M.(PubMed)
(2) IP6: a novel anti-cancer agent by Shamsuddin AM, Vucenik I, Cole KE.(PubMed)
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